RCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.87948342
2transcription from mitochondrial promoter (GO:0006390)6.38615005
3DNA deamination (GO:0045006)6.09087901
4replication fork processing (GO:0031297)5.99700152
5proline metabolic process (GO:0006560)5.79112845
6embryonic process involved in female pregnancy (GO:0060136)5.77809678
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.33483945
8nuclear pore complex assembly (GO:0051292)5.22963648
9somatic hypermutation of immunoglobulin genes (GO:0016446)5.09181889
10somatic diversification of immune receptors via somatic mutation (GO:0002566)5.09181889
11establishment of apical/basal cell polarity (GO:0035089)4.95499083
12formation of translation preinitiation complex (GO:0001731)4.87116236
13mitotic chromosome condensation (GO:0007076)4.84038206
14telomere maintenance via semi-conservative replication (GO:0032201)4.80678207
15positive regulation of protein homooligomerization (GO:0032464)4.74526466
16mitochondrial DNA metabolic process (GO:0032042)4.74203995
17nuclear pore organization (GO:0006999)4.67440010
18mitotic G1 DNA damage checkpoint (GO:0031571)4.62217436
19DNA strand renaturation (GO:0000733)4.51985345
20DNA strand elongation involved in DNA replication (GO:0006271)4.48065071
21regulation of integrin activation (GO:0033623)4.46653949
22viral mRNA export from host cell nucleus (GO:0046784)4.46245623
23regulation of translational fidelity (GO:0006450)4.44941318
24ribosomal small subunit biogenesis (GO:0042274)4.44110251
25establishment of integrated proviral latency (GO:0075713)4.34495054
26negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.31175005
27maturation of SSU-rRNA (GO:0030490)4.26390065
28oxidative demethylation (GO:0070989)4.24157720
29DNA strand elongation (GO:0022616)4.22397386
30establishment of monopolar cell polarity (GO:0061162)4.20751952
31establishment or maintenance of monopolar cell polarity (GO:0061339)4.20751952
32nucleotide-excision repair, DNA gap filling (GO:0006297)4.18910188
33base-excision repair (GO:0006284)4.17020828
34protein localization to chromosome, centromeric region (GO:0071459)4.16193534
35spliceosomal tri-snRNP complex assembly (GO:0000244)4.13092000
36regulation of protein homooligomerization (GO:0032462)4.05384672
37mitotic G1/S transition checkpoint (GO:0044819)4.04602941
38mRNA cleavage (GO:0006379)4.02972488
39G1 DNA damage checkpoint (GO:0044783)4.02898761
40telomere maintenance via recombination (GO:0000722)3.99771989
41ribosome assembly (GO:0042255)3.96600531
42mitotic metaphase plate congression (GO:0007080)3.96212734
43DNA replication checkpoint (GO:0000076)3.89035065
44pore complex assembly (GO:0046931)3.82133243
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.81922769
46ribosomal large subunit biogenesis (GO:0042273)3.81247436
47negative regulation of mRNA processing (GO:0050686)3.80004870
48ribonucleoprotein complex biogenesis (GO:0022613)3.79518111
49ribosomal small subunit assembly (GO:0000028)3.75016654
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.73098124
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.73098124
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.73098124
53regulation of sister chromatid cohesion (GO:0007063)3.70313547
54poly(A)+ mRNA export from nucleus (GO:0016973)3.68331802
55termination of RNA polymerase II transcription (GO:0006369)3.68090723
56regulation of double-strand break repair via homologous recombination (GO:0010569)3.67638737
57mitotic sister chromatid segregation (GO:0000070)3.67387873
58IMP biosynthetic process (GO:0006188)3.67289847
59viral transcription (GO:0019083)3.67218023
60dosage compensation (GO:0007549)3.65073780
61meiotic chromosome segregation (GO:0045132)3.62088692
62translational termination (GO:0006415)3.60123558
63positive regulation of chromosome segregation (GO:0051984)3.57750935
64mitotic recombination (GO:0006312)3.57734523
65non-recombinational repair (GO:0000726)3.57685430
66double-strand break repair via nonhomologous end joining (GO:0006303)3.57685430
67protein complex localization (GO:0031503)3.57026518
68negative regulation of cell cycle arrest (GO:0071157)3.56660647
69negative regulation of RNA splicing (GO:0033119)3.56139034
70DNA topological change (GO:0006265)3.55681494
71DNA double-strand break processing (GO:0000729)3.55517291
72maturation of 5.8S rRNA (GO:0000460)3.51906164
73negative regulation of JAK-STAT cascade (GO:0046426)3.49268745
74telomere maintenance via telomere lengthening (GO:0010833)3.49201221
75heterochromatin organization (GO:0070828)3.48881716
76regulation of RNA export from nucleus (GO:0046831)3.48469890
77mitochondrial RNA metabolic process (GO:0000959)3.48186498
78purine nucleobase biosynthetic process (GO:0009113)3.43867193
79regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.43757755
80kinetochore assembly (GO:0051382)3.42527817
81regulation of gene silencing by RNA (GO:0060966)3.41933763
82regulation of posttranscriptional gene silencing (GO:0060147)3.41933763
83regulation of gene silencing by miRNA (GO:0060964)3.41933763
84nucleobase-containing small molecule interconversion (GO:0015949)3.40989338
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.40532831
86DNA unwinding involved in DNA replication (GO:0006268)3.38086684
87chromosome condensation (GO:0030261)3.36589770
88DNA integration (GO:0015074)3.34816762
89regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34615801
90translational initiation (GO:0006413)3.33454297
91mitotic sister chromatid cohesion (GO:0007064)3.33432902
92mitotic nuclear envelope disassembly (GO:0007077)3.33227409
93IMP metabolic process (GO:0046040)3.30849240
94DNA replication initiation (GO:0006270)3.29406649
95histone H4-K12 acetylation (GO:0043983)3.29230126
96regulation of double-strand break repair (GO:2000779)3.29082585
97regulation of translational termination (GO:0006449)3.28924256
98embryonic placenta development (GO:0001892)3.28124300
99cellular protein complex localization (GO:0034629)3.26655822
100peptidyl-arginine omega-N-methylation (GO:0035247)3.26050531
101translational elongation (GO:0006414)3.23940469
102regulation of DNA damage checkpoint (GO:2000001)3.20751984
103SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.19947491
104establishment of viral latency (GO:0019043)3.19498359
105trophectodermal cell differentiation (GO:0001829)3.19426672
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18875359
107kinetochore organization (GO:0051383)3.18843788
108base-excision repair, AP site formation (GO:0006285)3.18580621
109ribosome biogenesis (GO:0042254)3.16921714
110sister chromatid segregation (GO:0000819)3.16670219
111DNA ligation (GO:0006266)3.16646274
112metaphase plate congression (GO:0051310)3.15064644
113negative regulation of mRNA metabolic process (GO:1903312)3.15043313
114DNA conformation change (GO:0071103)3.14706606
115CENP-A containing nucleosome assembly (GO:0034080)3.14496926
116rRNA processing (GO:0006364)3.13852718
117cotranslational protein targeting to membrane (GO:0006613)3.11949712
118protein targeting to ER (GO:0045047)3.10504961
119membrane disassembly (GO:0030397)3.07318260
120nuclear envelope disassembly (GO:0051081)3.07318260
121positive regulation by host of viral transcription (GO:0043923)3.04790576
122chromatin remodeling at centromere (GO:0031055)3.04382844
123apoptotic process involved in morphogenesis (GO:0060561)3.03097454
124protein localization to kinetochore (GO:0034501)3.01854616
125positive regulation of protein oligomerization (GO:0032461)3.00043553
126pre-miRNA processing (GO:0031054)2.99480146
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98720634
128RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.98345829
129mRNA splicing, via spliceosome (GO:0000398)2.98345829
130DNA packaging (GO:0006323)2.97306718
131spliceosomal snRNP assembly (GO:0000387)2.97293548
132rRNA metabolic process (GO:0016072)2.97143770
133tRNA aminoacylation for protein translation (GO:0006418)2.96643114
134L-serine metabolic process (GO:0006563)2.96283304
135nodal signaling pathway (GO:0038092)2.95965944
136mRNA export from nucleus (GO:0006406)2.95439482
137negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94744050
138folic acid metabolic process (GO:0046655)2.94131542
139RNA splicing, via transesterification reactions (GO:0000375)2.93806067
140regulation of mitochondrial translation (GO:0070129)2.93022300
141regulation of chromosome segregation (GO:0051983)2.92376164
142DNA duplex unwinding (GO:0032508)2.92250300
143chromatin assembly or disassembly (GO:0006333)2.91488734
144amino acid activation (GO:0043038)2.91075717
145tRNA aminoacylation (GO:0043039)2.91075717
146DNA geometric change (GO:0032392)2.90480945
147cellular protein complex disassembly (GO:0043624)2.89654152
148mitochondrial DNA replication (GO:0006264)2.88822505
149mRNA transport (GO:0051028)2.88190065
150folic acid-containing compound biosynthetic process (GO:0009396)2.87998819
151glutamine family amino acid biosynthetic process (GO:0009084)2.87796925
152protein localization to endoplasmic reticulum (GO:0070972)2.87504362
153resolution of meiotic recombination intermediates (GO:0000712)2.87175965
154nuclear envelope organization (GO:0006998)2.86582297
155viral life cycle (GO:0019058)2.86518835
156rRNA transcription (GO:0009303)2.86206991
157tetrahydrofolate metabolic process (GO:0046653)2.85431416
158negative regulation of fatty acid biosynthetic process (GO:0045717)2.85209474
159negative regulation of chromosome segregation (GO:0051985)2.84804577
160DNA replication-independent nucleosome organization (GO:0034724)2.84727613
161positive regulation of developmental pigmentation (GO:0048087)2.84272522
162RNA export from nucleus (GO:0006405)2.83807854
163histone arginine methylation (GO:0034969)2.83504401
164nucleobase biosynthetic process (GO:0046112)2.80039714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01501781
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.71787408
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.35445534
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.18051026
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.84775045
6* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.70181532
7* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58824076
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.45340346
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.44444008
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43429334
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.40851170
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.28646464
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.28646464
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.28646464
15VDR_21846776_ChIP-Seq_THP-1_Human2.14419905
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04018289
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.02728469
18MYC_22102868_ChIP-Seq_BL_Human2.00657736
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.93174799
20* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.87307255
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87192373
22NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83640030
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.81586559
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.81542658
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81270450
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80474716
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.75707258
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75586722
29YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74849245
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74187356
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71114577
32* XRN2_22483619_ChIP-Seq_HELA_Human1.67522749
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67504362
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65633054
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64752916
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61821151
37KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58382546
38TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58279928
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.57984930
40GABP_19822575_ChIP-Seq_HepG2_Human1.57566816
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.57153116
42POU5F1_16518401_ChIP-PET_MESCs_Mouse1.56944008
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.56323262
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.56198375
45NANOG_21062744_ChIP-ChIP_HESCs_Human1.55937440
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55834302
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53429762
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.52934217
49* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51736907
50DCP1A_22483619_ChIP-Seq_HELA_Human1.51610008
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51458067
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50039084
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46702874
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44434219
55KDM5A_27292631_Chip-Seq_BREAST_Human1.42303609
56* TTF2_22483619_ChIP-Seq_HELA_Human1.36973176
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.36569397
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35659570
59SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34259120
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33738423
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32159234
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.31321235
63VDR_23849224_ChIP-Seq_CD4+_Human1.29545091
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28943338
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28869200
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.28810209
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28245892
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.27601774
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.27330987
70CIITA_25753668_ChIP-Seq_RAJI_Human1.27177788
71* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26888980
72* ELK1_19687146_ChIP-ChIP_HELA_Human1.26580514
73PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26369087
74* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25616237
75LXR_22292898_ChIP-Seq_THP-1_Human1.25394898
76ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24627045
77ZNF263_19887448_ChIP-Seq_K562_Human1.24261681
78AR_21909140_ChIP-Seq_LNCAP_Human1.23272779
79KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22074848
80CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21683215
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21180390
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.19696592
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19636034
84* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.19532136
85NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.17632539
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15010371
87SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14090511
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13956108
89* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12849587
90PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.12652277
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.12429008
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12375706
93E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.12083244
94* CHD1_26751641_Chip-Seq_LNCaP_Human1.11910589
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11356535
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.11008047
97OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10888773
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.10003131
99* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.07895178
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06418091
101FOXP3_21729870_ChIP-Seq_TREG_Human1.06347974
102TFEB_21752829_ChIP-Seq_HELA_Human1.05930786
103SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04814106
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04435235
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03118009
106MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03094041
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02398512
108EGR1_19374776_ChIP-ChIP_THP-1_Human0.99607704
109NANOG_18692474_ChIP-Seq_MESCs_Mouse0.98288789
110KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98126942
111* RACK7_27058665_Chip-Seq_MCF-7_Human0.97902533
112* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97455225
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.96921185
114ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96674476
115CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96093980
116ELK3_25401928_ChIP-Seq_HUVEC_Human0.96061769
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95428075
118HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94756259
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.94339811
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93557459
121ETS1_21867929_ChIP-Seq_TH2_Mouse0.93027565
122GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92544546
123* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91968834
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91429351
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.90342020
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90339543
127TP63_19390658_ChIP-ChIP_HaCaT_Human0.90139827
128NCOR1_26117541_ChIP-Seq_K562_Human0.85631026
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83009897
130ATF3_27146783_Chip-Seq_COLON_Human0.82961430
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.82886874
132CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.82319441
133FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81294135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.02197393
2MP0010094_abnormal_chromosome_stability3.73059398
3MP0009278_abnormal_bone_marrow3.57042981
4MP0004957_abnormal_blastocyst_morpholog3.31474021
5MP0010030_abnormal_orbit_morphology3.29363779
6MP0003111_abnormal_nucleus_morphology3.22501518
7MP0003693_abnormal_embryo_hatching3.21663807
8MP0005171_absent_coat_pigmentation2.72440046
9MP0004233_abnormal_muscle_weight2.67532399
10MP0003077_abnormal_cell_cycle2.62222599
11MP0008058_abnormal_DNA_repair2.50465185
12MP0010352_gastrointestinal_tract_polyps2.25187032
13MP0003786_premature_aging2.17119087
14MP0008932_abnormal_embryonic_tissue2.16467468
15MP0003890_abnormal_embryonic-extraembry2.15382696
16MP0002877_abnormal_melanocyte_morpholog2.13639142
17MP0005397_hematopoietic_system_phenotyp2.07302655
18MP0001545_abnormal_hematopoietic_system2.07302655
19MP0002009_preneoplasia2.04506251
20MP0008877_abnormal_DNA_methylation1.98334067
21MP0005076_abnormal_cell_differentiation1.97213441
22MP0001730_embryonic_growth_arrest1.91297294
23MP0010234_abnormal_vibrissa_follicle1.90037433
24MP0001697_abnormal_embryo_size1.89771105
25MP0002653_abnormal_ependyma_morphology1.86846483
26MP0003283_abnormal_digestive_organ1.86468098
27MP0008995_early_reproductive_senescence1.84982722
28MP0004133_heterotaxia1.84874691
29MP0000350_abnormal_cell_proliferation1.84054110
30MP0002084_abnormal_developmental_patter1.83960102
31MP0003119_abnormal_digestive_system1.82743676
32MP0002086_abnormal_extraembryonic_tissu1.82316937
33MP0000537_abnormal_urethra_morphology1.81155007
34MP0004185_abnormal_adipocyte_glucose1.78233017
35MP0002085_abnormal_embryonic_tissue1.76393080
36MP0000490_abnormal_crypts_of1.74253969
37MP0001672_abnormal_embryogenesis/_devel1.73696056
38MP0005380_embryogenesis_phenotype1.73696056
39MP0004197_abnormal_fetal_growth/weight/1.72929716
40MP0009697_abnormal_copulation1.71227176
41MP0001293_anophthalmia1.69695913
42MP0005451_abnormal_body_composition1.69538343
43MP0003315_abnormal_perineum_morphology1.55252870
44MP0010307_abnormal_tumor_latency1.54214160
45MP0003567_abnormal_fetal_cardiomyocyte1.53619128
46MP0009672_abnormal_birth_weight1.52042842
47MP0005174_abnormal_tail_pigmentation1.45342042
48MP0002080_prenatal_lethality1.44846406
49MP0003984_embryonic_growth_retardation1.44092327
50MP0002088_abnormal_embryonic_growth/wei1.39180579
51MP0002282_abnormal_trachea_morphology1.38887084
52MP0002249_abnormal_larynx_morphology1.36914126
53MP0009379_abnormal_foot_pigmentation1.36484838
54MP0003453_abnormal_keratinocyte_physiol1.33202528
55MP0004808_abnormal_hematopoietic_stem1.32499865
56MP0002019_abnormal_tumor_incidence1.31181070
57MP0006035_abnormal_mitochondrial_morpho1.29228727
58MP0006072_abnormal_retinal_apoptosis1.28919815
59MP0002396_abnormal_hematopoietic_system1.27900268
60MP0008007_abnormal_cellular_replicative1.24664426
61MP0003718_maternal_effect1.24199591
62MP0002111_abnormal_tail_morphology1.19590307
63MP0001661_extended_life_span1.19261312
64MP0000678_abnormal_parathyroid_gland1.18887620
65MP0000313_abnormal_cell_death1.14878287
66MP0000358_abnormal_cell_content/1.09574993
67MP0000371_diluted_coat_color1.09177664
68MP0002269_muscular_atrophy1.08482482
69MP0005075_abnormal_melanosome_morpholog1.05097994
70MP0004264_abnormal_extraembryonic_tissu1.04816693
71MP0001849_ear_inflammation1.00425267
72MP0009053_abnormal_anal_canal1.00164273
73MP0009333_abnormal_splenocyte_physiolog0.97773749
74MP0001145_abnormal_male_reproductive0.97261306
75MP0000579_abnormal_nail_morphology0.97211946
76MP0000470_abnormal_stomach_morphology0.97048737
77MP0001346_abnormal_lacrimal_gland0.94117906
78MP0000462_abnormal_digestive_system0.93273497
79MP0003937_abnormal_limbs/digits/tail_de0.93145381
80MP0003172_abnormal_lysosome_physiology0.88947635
81MP0002932_abnormal_joint_morphology0.88539881
82MP0000015_abnormal_ear_pigmentation0.87909596
83MP0001727_abnormal_embryo_implantation0.87492975
84MP0001881_abnormal_mammary_gland0.86379653
85MP0002210_abnormal_sex_determination0.86029708
86MP0003705_abnormal_hypodermis_morpholog0.85237141
87MP0005384_cellular_phenotype0.85151784
88MP0002796_impaired_skin_barrier0.85122015
89MP0005621_abnormal_cell_physiology0.84605265
90MP0005501_abnormal_skin_physiology0.81790956
91MP0003935_abnormal_craniofacial_develop0.81737152
92MP0003221_abnormal_cardiomyocyte_apopto0.81265036
93MP0005266_abnormal_metabolism0.80671987
94MP0002075_abnormal_coat/hair_pigmentati0.80425217
95MP0001929_abnormal_gametogenesis0.80149981
96MP0006036_abnormal_mitochondrial_physio0.79164698
97MP0002114_abnormal_axial_skeleton0.78874753
98MP0005023_abnormal_wound_healing0.77512824
99MP0003755_abnormal_palate_morphology0.76077635
100MP0001216_abnormal_epidermal_layer0.76042203
101MP0000432_abnormal_head_morphology0.75912684
102MP0001340_abnormal_eyelid_morphology0.75512302
103MP0002160_abnormal_reproductive_system0.74176378
104MP0003942_abnormal_urinary_system0.73630798
105MP0000627_abnormal_mammary_gland0.73287799
106MP0003566_abnormal_cell_adhesion0.72337891
107MP0000653_abnormal_sex_gland0.72020281
108MP0003806_abnormal_nucleotide_metabolis0.71841111
109MP0000477_abnormal_intestine_morphology0.71317224
110MP0000428_abnormal_craniofacial_morphol0.70620109
111MP0000689_abnormal_spleen_morphology0.70422114
112MP0009703_decreased_birth_body0.69948831
113MP0003828_pulmonary_edema0.69421444
114MP0003385_abnormal_body_wall0.68979919
115MP0000762_abnormal_tongue_morphology0.68704173
116MP0003123_paternal_imprinting0.68683526
117MP0000703_abnormal_thymus_morphology0.68409735
118MP0001286_abnormal_eye_development0.68352406
119MP0002089_abnormal_postnatal_growth/wei0.68351765
120MP0000685_abnormal_immune_system0.65716625
121MP0002405_respiratory_system_inflammati0.65198829
122MP0002092_abnormal_eye_morphology0.64649423
123MP0002116_abnormal_craniofacial_bone0.64521379
124MP0006292_abnormal_olfactory_placode0.64337502
125MP0003115_abnormal_respiratory_system0.64125291
126MP0005666_abnormal_adipose_tissue0.63381692
127MP0005408_hypopigmentation0.63064819
128MP0001186_pigmentation_phenotype0.62226790
129MP0002006_tumorigenesis0.62125056
130MP0001348_abnormal_lacrimal_gland0.61902573
131MP0009931_abnormal_skin_appearance0.61741364
132MP0001915_intracranial_hemorrhage0.60892602
133MP0002697_abnormal_eye_size0.60756729
134MP0003186_abnormal_redox_activity0.60747679
135MP0000467_abnormal_esophagus_morphology0.60652890
136MP0002166_altered_tumor_susceptibility0.60174152
137MP0002060_abnormal_skin_morphology0.58256013
138MP0002722_abnormal_immune_system0.57943209
139MP0010630_abnormal_cardiac_muscle0.57401005
140MP0003941_abnormal_skin_development0.56052003
141MP0003699_abnormal_female_reproductive0.55552552
142MP0003656_abnormal_erythrocyte_physiolo0.55466573

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.06805971
2Facial hemangioma (HP:0000329)4.81699008
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.66372413
4Chromsome breakage (HP:0040012)4.37239277
5Concave nail (HP:0001598)4.32324061
6Pustule (HP:0200039)4.32123546
7Rectovaginal fistula (HP:0000143)4.31057463
8Rectal fistula (HP:0100590)4.31057463
9Annular pancreas (HP:0001734)4.30845266
10Poikiloderma (HP:0001029)4.26999266
11Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.21458681
12Reticulocytopenia (HP:0001896)4.01887467
13Intestinal fistula (HP:0100819)3.89243096
14Ulnar bowing (HP:0003031)3.81755501
15Vaginal fistula (HP:0004320)3.74424609
16Aplasia/hypoplasia of the humerus (HP:0006507)3.73924788
17Short humerus (HP:0005792)3.71120436
18Absent radius (HP:0003974)3.71089491
19Tongue fasciculations (HP:0001308)3.58522587
20Selective tooth agenesis (HP:0001592)3.55560333
21Increased IgM level (HP:0003496)3.54858247
22Progressive muscle weakness (HP:0003323)3.54523067
23Microvesicular hepatic steatosis (HP:0001414)3.51679041
24Alopecia of scalp (HP:0002293)3.48938602
25Absent forearm bone (HP:0003953)3.47931241
26Aplasia involving forearm bones (HP:0009822)3.47931241
27Patellar aplasia (HP:0006443)3.42422344
28Absent thumb (HP:0009777)3.40885296
29Squamous cell carcinoma (HP:0002860)3.31835719
30Muscle fibrillation (HP:0010546)3.31434118
31Hypochromic microcytic anemia (HP:0004840)3.29921559
32Basal cell carcinoma (HP:0002671)3.29599155
33Turricephaly (HP:0000262)3.29495003
34Male infertility (HP:0003251)3.19103440
35Aplasia/Hypoplasia of the patella (HP:0006498)3.17191849
36Multiple enchondromatosis (HP:0005701)3.14049112
37Orthostatic hypotension (HP:0001278)3.12802309
38Abnormal number of erythroid precursors (HP:0012131)3.09288148
39Intestinal atresia (HP:0011100)3.01227783
40Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.91460008
41Vertebral hypoplasia (HP:0008417)2.91460008
42Abnormality of the preputium (HP:0100587)2.89876130
43Coronal craniosynostosis (HP:0004440)2.89264804
44Premature graying of hair (HP:0002216)2.88182368
45Abnormality of the labia minora (HP:0012880)2.84313777
46Abnormal hemoglobin (HP:0011902)2.82113573
47Increased nuchal translucency (HP:0010880)2.81979233
48Macrocytic anemia (HP:0001972)2.77983450
49Broad alveolar ridges (HP:0000187)2.75860321
50Congenital hip dislocation (HP:0001374)2.74537308
51Trismus (HP:0000211)2.72003173
52Abnormality of male internal genitalia (HP:0000022)2.67914880
53Volvulus (HP:0002580)2.66593558
54Short chin (HP:0000331)2.66580059
55Progressive external ophthalmoplegia (HP:0000590)2.65566062
56Abnormality of the astrocytes (HP:0100707)2.62491676
57Astrocytoma (HP:0009592)2.62491676
58Breast hypoplasia (HP:0003187)2.61083619
59Anteriorly placed anus (HP:0001545)2.59893061
60Ependymoma (HP:0002888)2.59182895
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58572964
62Meckel diverticulum (HP:0002245)2.58427312
63Myelodysplasia (HP:0002863)2.58292847
64Abnormality of glycolysis (HP:0004366)2.56737783
65Aplastic anemia (HP:0001915)2.56382936
66Abnormal number of incisors (HP:0011064)2.49328706
67Deviation of the thumb (HP:0009603)2.48763646
68Proximal placement of thumb (HP:0009623)2.48747343
69Dysautonomia (HP:0002459)2.48133349
70Pallor (HP:0000980)2.47928451
71Septate vagina (HP:0001153)2.44175731
72Abnormality of reticulocytes (HP:0004312)2.42120879
73Rough bone trabeculation (HP:0100670)2.41750184
74Abnormality of chromosome stability (HP:0003220)2.39182770
75Acute lymphatic leukemia (HP:0006721)2.37375069
76Abnormality of the aortic arch (HP:0012303)2.36113767
77Abnormal gallbladder physiology (HP:0012438)2.35610327
78Cholecystitis (HP:0001082)2.35610327
79Albinism (HP:0001022)2.34691114
80Premature skin wrinkling (HP:0100678)2.33460413
81Abnormality of the ileum (HP:0001549)2.32815998
82Capillary hemangiomas (HP:0005306)2.32014602
83Hypoplasia of the radius (HP:0002984)2.31996495
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.28364887
85Overlapping toe (HP:0001845)2.28012486
86Alacrima (HP:0000522)2.27990515
87Diaphragmatic weakness (HP:0009113)2.26787683
88Neoplasm of the oral cavity (HP:0100649)2.26077171
89Hypotelorism (HP:0000601)2.25320442
90Vertebral fusion (HP:0002948)2.23500657
91Spinal muscular atrophy (HP:0007269)2.23193253
92Hyperacusis (HP:0010780)2.23125132
93Hypochromic anemia (HP:0001931)2.21872056
94Nephroblastoma (Wilms tumor) (HP:0002667)2.21075116
95Birth length less than 3rd percentile (HP:0003561)2.17307934
96Increased serum pyruvate (HP:0003542)2.15205539
97IgA deficiency (HP:0002720)2.14808936
98Short thumb (HP:0009778)2.14000746
99Ankyloglossia (HP:0010296)2.11905452
100Hypotrichosis (HP:0001006)2.11896671
101Duodenal stenosis (HP:0100867)2.10971185
102Small intestinal stenosis (HP:0012848)2.10971185
103Bifid uvula (HP:0000193)2.10887244
104Bowed forearm bones (HP:0003956)2.10363338
105Bowing of the arm (HP:0006488)2.10363338
106Choanal stenosis (HP:0000452)2.08668636
107Glioma (HP:0009733)2.08515383
108Pancreatic islet-cell hyperplasia (HP:0004510)2.08311986
109Homocystinuria (HP:0002156)2.05574665
110Abnormality of homocysteine metabolism (HP:0010919)2.05574665
111Gastrointestinal atresia (HP:0002589)2.04288867
112Cerebral aneurysm (HP:0004944)2.04094149
113Degeneration of anterior horn cells (HP:0002398)2.03842434
114Abnormality of the anterior horn cell (HP:0006802)2.03842434
115Horseshoe kidney (HP:0000085)2.03026066
116Asymmetry of the thorax (HP:0001555)2.01962501
117Large for gestational age (HP:0001520)2.01624100
118Embryonal renal neoplasm (HP:0011794)2.01248067
119Abnormality of the umbilical cord (HP:0010881)2.00913091
120Rhabdomyosarcoma (HP:0002859)2.00559864
121Short 5th finger (HP:0009237)2.00343041
122Joint stiffness (HP:0001387)2.00255796
123Premature ovarian failure (HP:0008209)1.99266394
124Hamartoma (HP:0010566)1.98567310
125Cafe-au-lait spot (HP:0000957)1.97620794
126Choanal atresia (HP:0000453)1.96852025
127Atresia of the external auditory canal (HP:0000413)1.96088246
128Oral leukoplakia (HP:0002745)1.95592562
129Ragged-red muscle fibers (HP:0003200)1.95565667
130Duplication of thumb phalanx (HP:0009942)1.94358035
131Increased number of teeth (HP:0011069)1.94289984
132Testicular atrophy (HP:0000029)1.94062045
133Insomnia (HP:0100785)1.92676815
134Muscle fiber atrophy (HP:0100295)1.91128475
135Abnormal trabecular bone morphology (HP:0100671)1.91072695
136Facial cleft (HP:0002006)1.90651295
137Abnormality of the carotid arteries (HP:0005344)1.90612358
138Abdominal situs inversus (HP:0003363)1.89913422
139Abnormality of abdominal situs (HP:0011620)1.89913422
140Split hand (HP:0001171)1.89180493
141Pancytopenia (HP:0001876)1.88203138
142Abnormality of methionine metabolism (HP:0010901)1.87333081
143Abnormal lung lobation (HP:0002101)1.87261897
144Medulloblastoma (HP:0002885)1.86362756
145Urinary glycosaminoglycan excretion (HP:0003541)1.85416305
146Mucopolysacchariduria (HP:0008155)1.85416305
147Abnormality of cochlea (HP:0000375)1.84705586
148Impulsivity (HP:0100710)1.84048787
14911 pairs of ribs (HP:0000878)1.83723894
150High anterior hairline (HP:0009890)1.83423961
151Aplasia of the musculature (HP:0100854)1.83349913
152Cerebral hypomyelination (HP:0006808)1.80442363
153Urethral obstruction (HP:0000796)1.79952622
154Polycythemia (HP:0001901)1.78635334
155Increased hepatocellular lipid droplets (HP:0006565)1.78010618
156Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.77760704
157Sparse lateral eyebrow (HP:0005338)1.77611068
158Abnormal umbilical cord blood vessels (HP:0011403)1.75970961
159Single umbilical artery (HP:0001195)1.75970961
160Abnormality of the fetal cardiovascular system (HP:0010948)1.75970961
161Hemivertebrae (HP:0002937)1.75871330
162Decreased lacrimation (HP:0000633)1.75677017
163Abnormalities of placenta or umbilical cord (HP:0001194)1.74273025
164Missing ribs (HP:0000921)1.73288206
165Sparse eyelashes (HP:0000653)1.72939420
166Glossoptosis (HP:0000162)1.71774466
167Duplicated collecting system (HP:0000081)1.71733530
168Abnormality of cells of the erythroid lineage (HP:0012130)1.71165553
169Ureteral duplication (HP:0000073)1.70084268
170Deep philtrum (HP:0002002)1.68867318
171Abnormality of oral frenula (HP:0000190)1.68853126
172Neoplasm of the pancreas (HP:0002894)1.68778881
173Dysmetric saccades (HP:0000641)1.68330692
174Ectopic kidney (HP:0000086)1.67450704
175Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66917323
176Reticulocytosis (HP:0001923)1.66441969
177Abnormality of DNA repair (HP:0003254)1.65389311
178Secondary amenorrhea (HP:0000869)1.63908900
179Reduced antithrombin III activity (HP:0001976)1.62401502
180Nasolacrimal duct obstruction (HP:0000579)1.59439143
181Triphalangeal thumb (HP:0001199)1.58415629
182Abnormality of the duodenum (HP:0002246)1.58184441
183Broad distal phalanx of finger (HP:0009836)1.58099502
184Unilateral renal agenesis (HP:0000122)1.58010027
185Preauricular skin tag (HP:0000384)1.57875605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.51032587
2DDR24.22790127
3MAPK153.81321713
4MAP3K63.76722460
5SMG13.24875515
6MAP3K113.19694057
7VRK23.09403483
8PBK2.78194764
9TYRO32.52459942
10MATK2.51628890
11FGR2.31547598
12BUB12.29129054
13PINK12.24594588
14CDK72.22906684
15PIM22.18061296
16DAPK12.14365432
17CDC72.06419062
18WEE12.06378193
19BMX1.94047953
20IRAK31.80485227
21UHMK11.78989490
22CSK1.73742838
23PDGFRA1.70549055
24YES11.70088264
25NEK21.66721460
26DYRK1B1.65660852
27TAF11.63110152
28PRKD21.58619012
29MAP3K101.55197249
30PLK11.52130277
31CDK61.51759148
32PIM11.50987936
33CHEK21.47965696
34LATS21.46630801
35EIF2AK31.44825349
36DYRK31.40861761
37PLK31.32956720
38CDK121.32162485
39NME11.28860775
40AKT31.24777409
41RPS6KB21.21574233
42CDK81.17648238
43ATR1.14502525
44NEK11.13667250
45MST1R1.12287068
46TTK1.11554680
47STK161.08550008
48TRPM71.07240137
49RPS6KC11.07221196
50RPS6KL11.07221196
51VRK11.05958920
52EPHA21.01656244
53SIK11.00277150
54MST40.99948637
55CLK10.99507498
56BRD40.97206739
57ZAK0.94840416
58TESK20.94178629
59MAPK110.93734375
60RPS6KA60.92350918
61MTOR0.89244066
62AURKB0.86682374
63PRPF4B0.85972946
64RPS6KA40.85251677
65CDK40.84568623
66AURKA0.82740178
67GSK3A0.82383269
68CHEK10.81552547
69CDC42BPA0.81538433
70CDK20.78737555
71TAOK20.78281379
72EIF2AK20.77984224
73BRAF0.76236594
74STK100.75607467
75TRIB30.75183956
76MAP3K80.69996208
77EEF2K0.69249677
78BRSK20.68703022
79ALK0.68102904
80CCNB10.66406114
81RPS6KA10.66139118
82PAK40.63335227
83ATM0.59570390
84ACVR1B0.58398321
85CSNK2A10.58257983
86STK30.56996534
87PKN20.56697017
88NME20.55585860
89ILK0.52457359
90CSNK2A20.51792441
91RAF10.51445037
92KSR20.50473914
93CDK90.50279298
94TLK10.48788347
95PDK20.48337944
96EIF2AK10.47954252
97SRPK10.45836656
98PRKAA10.45344424
99PAK10.45238555
100LRRK20.44712238
101HIPK20.43694919
102MAPKAPK30.42851090
103* CDK10.42544578
104TSSK60.42447848
105BRSK10.42256129
106FGFR40.41536055
107PAK20.40298554
108MAP4K10.39921425
109PHKG20.39433843
110PHKG10.39433843
111PLK40.38350642
112RPS6KB10.37994469
113MKNK10.36859190
114PNCK0.36430953
115ARAF0.36300678
116STK40.36130890
117MAPK10.35646315
118EGFR0.34831396
119LATS10.34791761
120CAMK1D0.34684399
121ERBB40.34037583
122MKNK20.33715909
123FLT30.32826690
124LYN0.32783581
125MAPK140.32780936
126MAP3K90.31442523
127TAOK10.30699269
128PRKDC0.30446206
129MELK0.29005375
130CDK11A0.28949863
131AKT20.28301466
132MAPK30.28161223
133IRAK20.27686292
134MAPKAPK20.27458752
135PRKCI0.27017610
136SCYL20.26150671
137PASK0.25681884
138CSNK1E0.25118093
139MAPK100.24072376

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.21014459
2DNA replication_Homo sapiens_hsa030305.02592668
3Base excision repair_Homo sapiens_hsa034104.50235132
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.25224199
5Fatty acid biosynthesis_Homo sapiens_hsa000613.23651281
6Spliceosome_Homo sapiens_hsa030403.00607754
7RNA transport_Homo sapiens_hsa030132.91167389
8Nucleotide excision repair_Homo sapiens_hsa034202.83530822
9Homologous recombination_Homo sapiens_hsa034402.52640810
10Cell cycle_Homo sapiens_hsa041102.32630295
11mRNA surveillance pathway_Homo sapiens_hsa030152.19112639
12Fanconi anemia pathway_Homo sapiens_hsa034602.13264728
13Ribosome_Homo sapiens_hsa030102.03933019
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.98637730
15One carbon pool by folate_Homo sapiens_hsa006701.95212211
16p53 signaling pathway_Homo sapiens_hsa041151.84961951
17RNA polymerase_Homo sapiens_hsa030201.58243377
18Biosynthesis of amino acids_Homo sapiens_hsa012301.56938300
19Proteasome_Homo sapiens_hsa030501.49009221
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46154627
21Hippo signaling pathway_Homo sapiens_hsa043901.42342565
22mTOR signaling pathway_Homo sapiens_hsa041501.40561521
23Notch signaling pathway_Homo sapiens_hsa043301.39068098
24Hedgehog signaling pathway_Homo sapiens_hsa043401.37294372
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37247679
26Sulfur relay system_Homo sapiens_hsa041221.32608654
27Pyrimidine metabolism_Homo sapiens_hsa002401.31931933
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27227335
29Folate biosynthesis_Homo sapiens_hsa007901.25780436
30Arginine and proline metabolism_Homo sapiens_hsa003301.23364579
31Pyruvate metabolism_Homo sapiens_hsa006201.22451116
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16133860
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12994919
34Oocyte meiosis_Homo sapiens_hsa041141.12583668
35RNA degradation_Homo sapiens_hsa030181.10379791
36Adherens junction_Homo sapiens_hsa045201.08597076
37Bladder cancer_Homo sapiens_hsa052191.06778059
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03362276
39Basal transcription factors_Homo sapiens_hsa030221.02484685
40TGF-beta signaling pathway_Homo sapiens_hsa043500.99783187
41Basal cell carcinoma_Homo sapiens_hsa052170.99346843
42Circadian rhythm_Homo sapiens_hsa047100.98756905
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.91731839
44Shigellosis_Homo sapiens_hsa051310.89383496
45Viral carcinogenesis_Homo sapiens_hsa052030.87965988
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86651380
47Fructose and mannose metabolism_Homo sapiens_hsa000510.82988821
48Non-homologous end-joining_Homo sapiens_hsa034500.82962836
49MicroRNAs in cancer_Homo sapiens_hsa052060.82835923
50Huntingtons disease_Homo sapiens_hsa050160.82205752
51Epstein-Barr virus infection_Homo sapiens_hsa051690.79189583
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77019196
53Parkinsons disease_Homo sapiens_hsa050120.76821980
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76251061
55Lysine degradation_Homo sapiens_hsa003100.75552841
56Wnt signaling pathway_Homo sapiens_hsa043100.75423902
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75122546
58Colorectal cancer_Homo sapiens_hsa052100.74092052
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72064958
60Primary immunodeficiency_Homo sapiens_hsa053400.71997745
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.69993414
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.68846579
63Thyroid cancer_Homo sapiens_hsa052160.68052483
64Small cell lung cancer_Homo sapiens_hsa052220.67408873
65Protein export_Homo sapiens_hsa030600.63958648
66VEGF signaling pathway_Homo sapiens_hsa043700.62061628
67Chronic myeloid leukemia_Homo sapiens_hsa052200.61843934
68Herpes simplex infection_Homo sapiens_hsa051680.61178792
69Non-small cell lung cancer_Homo sapiens_hsa052230.60487395
70Legionellosis_Homo sapiens_hsa051340.60346393
71Selenocompound metabolism_Homo sapiens_hsa004500.60017540
72Oxidative phosphorylation_Homo sapiens_hsa001900.59655935
73HTLV-I infection_Homo sapiens_hsa051660.57891191
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.55071514
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54814821
76Pancreatic cancer_Homo sapiens_hsa052120.54766483
77Glutathione metabolism_Homo sapiens_hsa004800.54279525
78Acute myeloid leukemia_Homo sapiens_hsa052210.50707869
79Steroid biosynthesis_Homo sapiens_hsa001000.49454114
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48784976
81Viral myocarditis_Homo sapiens_hsa054160.47629063
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.47137976
83Systemic lupus erythematosus_Homo sapiens_hsa053220.45955665
84Fatty acid metabolism_Homo sapiens_hsa012120.45513105
85Tight junction_Homo sapiens_hsa045300.44455247
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.44067717
87Galactose metabolism_Homo sapiens_hsa000520.42834052
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42201759
89Pentose phosphate pathway_Homo sapiens_hsa000300.41279712
90Arginine biosynthesis_Homo sapiens_hsa002200.40185709
91Alcoholism_Homo sapiens_hsa050340.38769946
92Purine metabolism_Homo sapiens_hsa002300.38700675
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38620085
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38015915
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37657996
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36997533
97Fatty acid elongation_Homo sapiens_hsa000620.36118648
98Metabolic pathways_Homo sapiens_hsa011000.35159391
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34446467
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34391967
101Vitamin B6 metabolism_Homo sapiens_hsa007500.33976751
102Alzheimers disease_Homo sapiens_hsa050100.33397749
103AMPK signaling pathway_Homo sapiens_hsa041520.32484073
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32328921
105Vitamin digestion and absorption_Homo sapiens_hsa049770.31137088
106Hepatitis B_Homo sapiens_hsa051610.30739499
107Drug metabolism - other enzymes_Homo sapiens_hsa009830.29540406
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.29269836
109Melanoma_Homo sapiens_hsa052180.28701206
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26795233
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26308352
112HIF-1 signaling pathway_Homo sapiens_hsa040660.26067896
113Carbon metabolism_Homo sapiens_hsa012000.25666534
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25189004
115Pathways in cancer_Homo sapiens_hsa052000.24607396
116Proteoglycans in cancer_Homo sapiens_hsa052050.23964343
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22658947
118N-Glycan biosynthesis_Homo sapiens_hsa005100.21902571
119Apoptosis_Homo sapiens_hsa042100.21408220
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21161095
121Insulin signaling pathway_Homo sapiens_hsa049100.20693016
122Glioma_Homo sapiens_hsa052140.19975685
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19771055
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19735454
125Prostate cancer_Homo sapiens_hsa052150.19688444
126Renal cell carcinoma_Homo sapiens_hsa052110.18583271
127Endometrial cancer_Homo sapiens_hsa052130.18549028
128Antigen processing and presentation_Homo sapiens_hsa046120.18099634
129ErbB signaling pathway_Homo sapiens_hsa040120.16032288

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