RC3H1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)5.41269761
2nuclear pore complex assembly (GO:0051292)4.31619664
3* cytoplasmic mRNA processing body assembly (GO:0033962)4.23203348
4nuclear pore organization (GO:0006999)3.89736843
5mitotic sister chromatid cohesion (GO:0007064)3.60577216
6negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.56678291
7negative regulation of translation, ncRNA-mediated (GO:0040033)3.56678291
8regulation of translation, ncRNA-mediated (GO:0045974)3.56678291
9histone mRNA catabolic process (GO:0071044)3.53474880
10growth hormone receptor signaling pathway (GO:0060396)3.51037613
11regulation of B cell receptor signaling pathway (GO:0050855)3.45075458
12regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.41048792
13positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.41048792
14positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.37835307
15regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.37835307
16pore complex assembly (GO:0046931)3.36379421
17retrograde transport, vesicle recycling within Golgi (GO:0000301)3.32072922
18positive regulation of mRNA catabolic process (GO:0061014)3.31168355
19keratinocyte development (GO:0003334)3.29790327
20regulation of RNA export from nucleus (GO:0046831)3.18090027
21protein targeting to Golgi (GO:0000042)3.13456749
22histone H3-K36 demethylation (GO:0070544)3.12990859
23positive regulation of granulocyte differentiation (GO:0030854)3.07984432
24microglial cell activation (GO:0001774)3.07487812
25histone H3-K4 trimethylation (GO:0080182)3.05922698
26regulation of mRNA catabolic process (GO:0061013)3.04542550
27neutrophil mediated immunity (GO:0002446)3.04501172
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98721257
29cellular response to growth hormone stimulus (GO:0071378)2.97616306
30cellular response to ethanol (GO:0071361)2.94591938
31regulation of protein polyubiquitination (GO:1902914)2.92558142
32negative regulation of neurotransmitter secretion (GO:0046929)2.92350113
33hepatocyte apoptotic process (GO:0097284)2.91469602
34histone H3-K9 demethylation (GO:0033169)2.91281525
35establishment of protein localization to Golgi (GO:0072600)2.90060616
36cellular response to interleukin-15 (GO:0071350)2.89981057
37negative regulation of cell killing (GO:0031342)2.87981380
38negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.87981380
39definitive hemopoiesis (GO:0060216)2.87722146
40histone lysine demethylation (GO:0070076)2.85356736
41DNA deamination (GO:0045006)2.84982108
42embryonic epithelial tube formation (GO:0001838)2.81868889
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80827310
44regulation of interleukin-12 biosynthetic process (GO:0045075)2.80777982
45regulation of gamma-delta T cell differentiation (GO:0045586)2.79862919
46response to interleukin-15 (GO:0070672)2.75650272
47myeloid leukocyte mediated immunity (GO:0002444)2.74621822
48Golgi to endosome transport (GO:0006895)2.71921980
49regulation of regulatory T cell differentiation (GO:0045589)2.71403806
50regulation of nucleobase-containing compound transport (GO:0032239)2.71197349
51ER overload response (GO:0006983)2.70739302
52regulation of memory T cell differentiation (GO:0043380)2.70660909
53limb bud formation (GO:0060174)2.70453639
54positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.69982550
55histone demethylation (GO:0016577)2.66775820
56interferon-gamma production (GO:0032609)2.66169817
57negative regulation of cAMP-mediated signaling (GO:0043951)2.66124798
58regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.63118060
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62417722
60fucose catabolic process (GO:0019317)2.61095765
61L-fucose metabolic process (GO:0042354)2.61095765
62L-fucose catabolic process (GO:0042355)2.61095765
63corticosteroid receptor signaling pathway (GO:0031958)2.59844203
64regulation of establishment of cell polarity (GO:2000114)2.58827747
65regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57806979
66epithelial tube formation (GO:0072175)2.57519441
67cellular extravasation (GO:0045123)2.56880405
68glial cell proliferation (GO:0014009)2.56022585
69positive regulation of gamma-delta T cell activation (GO:0046645)2.55997900
70adaptation of signaling pathway (GO:0023058)2.54509784
71protein prenylation (GO:0018342)2.53030752
72prenylation (GO:0097354)2.53030752
73macrophage activation involved in immune response (GO:0002281)2.51674295
74RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.50434781
75neutrophil activation involved in immune response (GO:0002283)2.49945984
76detection of molecule of bacterial origin (GO:0032490)2.48434225
77dopamine transport (GO:0015872)2.48097770
78RNA destabilization (GO:0050779)2.47672547
79negative regulation of immunoglobulin mediated immune response (GO:0002890)2.44803777
80negative regulation of B cell mediated immunity (GO:0002713)2.44803777
81microtubule anchoring (GO:0034453)2.43730373
82positive regulation of cell cycle checkpoint (GO:1901978)2.43417769
83embryonic camera-type eye morphogenesis (GO:0048596)2.43376441
84positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42491488
85regulation of hippo signaling (GO:0035330)2.42109341
86early endosome to late endosome transport (GO:0045022)2.42071106
87ether lipid metabolic process (GO:0046485)2.41669425
88regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.41232855
89mesodermal cell differentiation (GO:0048333)2.41002078
90phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.40214114
91protein K63-linked deubiquitination (GO:0070536)2.40177676
92regulation of protein glycosylation (GO:0060049)2.40026068
93DNA demethylation (GO:0080111)2.39942139
94positive regulation of interferon-beta production (GO:0032728)2.39930311
95negative regulation of lymphocyte mediated immunity (GO:0002707)2.39212447
96negative regulation of protein oligomerization (GO:0032460)2.38642417
97lactate metabolic process (GO:0006089)2.37947022
98positive regulation of DNA recombination (GO:0045911)2.36874096
99kidney morphogenesis (GO:0060993)2.36234510
100interkinetic nuclear migration (GO:0022027)2.35952028
101neutrophil activation (GO:0042119)2.35937951
102embryonic retina morphogenesis in camera-type eye (GO:0060059)2.35282112
103regulation of interleukin-6 biosynthetic process (GO:0045408)2.34512899
104protein K48-linked deubiquitination (GO:0071108)2.34503080
105* alpha-beta T cell differentiation (GO:0046632)2.34343754
106NLS-bearing protein import into nucleus (GO:0006607)2.33648677
107negative regulation of neurotransmitter transport (GO:0051589)2.33349382
108regulation of mRNA 3-end processing (GO:0031440)2.32655145
109positive regulation of mRNA 3-end processing (GO:0031442)2.32246734
110macrophage activation (GO:0042116)2.31770171
111negative regulation of osteoclast differentiation (GO:0045671)2.31586259
112* CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.31347720
113* T-helper cell differentiation (GO:0042093)2.31347720
114histone H3-K4 methylation (GO:0051568)2.31042718
115prostate gland growth (GO:0060736)2.30003959
116monoubiquitinated protein deubiquitination (GO:0035520)2.29715308
117nerve growth factor signaling pathway (GO:0038180)2.28946049
118negative regulation of DNA repair (GO:0045738)2.28595106
119platelet-derived growth factor receptor signaling pathway (GO:0048008)2.28020170
120gland morphogenesis (GO:0022612)2.27961231
121tyrosine phosphorylation of STAT protein (GO:0007260)2.27778991
122regulation of DNA endoreduplication (GO:0032875)2.27295887
123protein dealkylation (GO:0008214)2.27219798
124protein demethylation (GO:0006482)2.27219798
125regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.27212332
126regulation of pigment cell differentiation (GO:0050932)2.25809917
127chondrocyte development (GO:0002063)2.25724318
128B cell receptor signaling pathway (GO:0050853)2.24116365
129positive T cell selection (GO:0043368)2.24005424
130positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.23824685
131positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.23824685
132positive regulation of mitotic sister chromatid separation (GO:1901970)2.23824685
133glucocorticoid receptor signaling pathway (GO:0042921)2.23195445
134rRNA catabolic process (GO:0016075)2.22770625
135interferon-gamma secretion (GO:0072643)2.22570566
136regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.17214461
137negative regulation of histone methylation (GO:0031061)2.15625300
138positive regulation of mRNA metabolic process (GO:1903313)2.15451888
139peptidyl-lysine trimethylation (GO:0018023)2.14892706
140activated T cell proliferation (GO:0050798)2.13000889
141hippo signaling (GO:0035329)2.12412497
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.12272800
143myelin assembly (GO:0032288)2.10867101
144embryonic process involved in female pregnancy (GO:0060136)2.10726087
145protein K11-linked deubiquitination (GO:0035871)2.08379435
146JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.06605378
147branching involved in prostate gland morphogenesis (GO:0060442)2.01945594
148regulation of T cell tolerance induction (GO:0002664)1.99455890
149positive regulation of mRNA processing (GO:0050685)1.99352749
150positive regulation of interleukin-2 production (GO:0032743)1.99257427
151lung lobe morphogenesis (GO:0060463)1.98313590
152Rap protein signal transduction (GO:0032486)1.97588398
153regulation of establishment or maintenance of cell polarity (GO:0032878)1.97552209
154pre-miRNA processing (GO:0031054)1.97456997
155pathway-restricted SMAD protein phosphorylation (GO:0060389)1.96131245
156negative regulation of glycogen biosynthetic process (GO:0045719)1.95977773
157positive thymic T cell selection (GO:0045059)1.95789921
158positive regulation by symbiont of host defense response (GO:0052509)1.94560303
159modulation by symbiont of host defense response (GO:0052031)1.94560303
160modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.94560303
161modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.94560303
162positive regulation by organism of defense response of other organism involved in symbiotic interact1.94560303
163modulation by symbiont of host immune response (GO:0052553)1.94560303
164negative regulation of osteoblast proliferation (GO:0033689)1.94506266
165protein localization to endosome (GO:0036010)1.93635294
166regulation of gamma-delta T cell activation (GO:0046643)1.93408606
167heterotypic cell-cell adhesion (GO:0034113)1.93178091
168lymph vessel development (GO:0001945)1.92824748
169regulation of histone H3-K9 methylation (GO:0051570)1.92203269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.49915628
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.93240108
3* CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.21736779
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10961515
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.97708378
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.67139661
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.50507820
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39891369
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.10623063
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.08289667
11ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08099191
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04584635
13IGF1R_20145208_ChIP-Seq_DFB_Human2.00030006
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.96937131
15AR_21572438_ChIP-Seq_LNCaP_Human1.96081138
16SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.91989097
17ZNF274_21170338_ChIP-Seq_K562_Hela1.91374616
18WT1_19549856_ChIP-ChIP_CCG9911_Human1.85526795
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78368670
20VDR_22108803_ChIP-Seq_LS180_Human1.77739573
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76644385
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76326209
23RUNX_20019798_ChIP-Seq_JUKART_Human1.66849459
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.66759267
25* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65956257
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62911273
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.62031037
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61119972
29TCF4_18268006_ChIP-ChIP_LS174T_Human1.59800939
30TAF15_26573619_Chip-Seq_HEK293_Human1.57933755
31AHR_22903824_ChIP-Seq_MCF-7_Human1.57635302
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55861479
33* NFE2_27457419_Chip-Seq_LIVER_Mouse1.55445563
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53502049
35* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.53319888
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.47607157
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46793359
38NOTCH1_21737748_ChIP-Seq_TLL_Human1.46002549
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43948417
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.41109905
41TP53_16413492_ChIP-PET_HCT116_Human1.40596678
42CBP_20019798_ChIP-Seq_JUKART_Human1.38674007
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38674007
44* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38143561
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37856468
46* P53_22387025_ChIP-Seq_ESCs_Mouse1.36846991
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36672807
48VDR_24787735_ChIP-Seq_THP-1_Human1.35892557
49* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34898630
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.34670986
51GATA2_21666600_ChIP-Seq_HMVEC_Human1.34513050
52CJUN_26792858_Chip-Seq_BT549_Human1.34066018
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33980094
54FOXO3_23340844_ChIP-Seq_DLD1_Human1.33378560
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33043316
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32221901
57P300_19829295_ChIP-Seq_ESCs_Human1.28625164
58* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28029339
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27308468
60* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26269986
61RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.25410041
62STAT3_23295773_ChIP-Seq_U87_Human1.24405046
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23925248
64AR_25329375_ChIP-Seq_VCAP_Human1.23738655
65RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23197886
66FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23177581
67GBX2_23144817_ChIP-Seq_PC3_Human1.23093162
68EWS_26573619_Chip-Seq_HEK293_Human1.22938673
69* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22929733
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22660533
71* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.22264910
72FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21900895
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21554549
74* SMAD4_21799915_ChIP-Seq_A2780_Human1.21325338
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.21233044
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20969155
77PRDM14_20953172_ChIP-Seq_ESCs_Human1.20923740
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.20902057
79* P300_18555785_Chip-Seq_ESCs_Mouse1.19054302
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18737599
81* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18083684
82ER_23166858_ChIP-Seq_MCF-7_Human1.17776893
83* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16954146
84RXR_22108803_ChIP-Seq_LS180_Human1.16159571
85IRF8_22096565_ChIP-ChIP_GC-B_Human1.15694315
86* TCF4_22108803_ChIP-Seq_LS180_Human1.15443351
87NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14083020
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14083020
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13366331
90* NANOG_18555785_Chip-Seq_ESCs_Mouse1.13254882
91GATA3_26560356_Chip-Seq_TH2_Human1.13140726
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13020028
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12978043
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.12848623
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12749217
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12749217
97* STAT3_18555785_Chip-Seq_ESCs_Mouse1.11442213
98RBPJ_22232070_ChIP-Seq_NCS_Mouse1.11441727
99IRF8_27001747_Chip-Seq_BMDM_Mouse1.11078513
100* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10347956
101* OCT4_18555785_Chip-Seq_ESCs_Mouse1.10084690
102* BRD4_25478319_ChIP-Seq_HGPS_Human1.09648198
103RUNX2_22187159_ChIP-Seq_PCA_Human1.08657745
104NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08584718
105* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08428793
106TCF4_23295773_ChIP-Seq_U87_Human1.07831124
107TP53_18474530_ChIP-ChIP_U2OS_Human1.07195944
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.07040434
109* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05643435
110FUS_26573619_Chip-Seq_HEK293_Human1.05636675
111MYB_26560356_Chip-Seq_TH2_Human1.04690003
112PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04521976
113TRIM28_21343339_ChIP-Seq_HEK293_Human1.03863441
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03327607
115EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03203128
116TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02725959
117* E2F1_18555785_Chip-Seq_ESCs_Mouse1.02695355
118* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02635564
119GATA3_27048872_Chip-Seq_THYMUS_Human1.02113345
120POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00661125
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00661125
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00550913
123TP63_23658742_ChIP-Seq_EP156T_Human0.99546509
124SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98051468
125BCAT_22108803_ChIP-Seq_LS180_Human0.98033858
126GATA1_22025678_ChIP-Seq_K562_Human0.97236766
127NFIB_24661679_ChIP-Seq_LUNG_Mouse0.96280644
128* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96090154
129* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95643030
130PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95595121
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95411460
132PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.95209214
133CDX2_22108803_ChIP-Seq_LS180_Human0.94079181
134* CMYC_18555785_Chip-Seq_ESCs_Mouse0.93729799
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92457147
136TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91097286
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.91091399
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91090726
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90869481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia4.54108134
2MP0003724_increased_susceptibility_to4.26953413
3MP0000569_abnormal_digit_pigmentation3.72185325
4MP0002166_altered_tumor_susceptibility3.13356436
5MP0003300_gastrointestinal_ulcer3.05177501
6MP0003195_calcinosis3.01007417
7MP0003183_abnormal_peptide_metabolism2.86096735
8MP0005076_abnormal_cell_differentiation2.80736984
9MP0002006_tumorigenesis2.73350467
10MP0003787_abnormal_imprinting2.27100549
11MP0004381_abnormal_hair_follicle2.25965954
12MP0008057_abnormal_DNA_replication2.19483800
13MP0001835_abnormal_antigen_presentation2.11354352
14MP0008995_early_reproductive_senescence2.06726207
15MP0001299_abnormal_eye_distance/2.05729239
16MP0010678_abnormal_skin_adnexa2.01480331
17MP0003045_fibrosis2.00158597
18MP0005174_abnormal_tail_pigmentation1.98760487
19MP0005075_abnormal_melanosome_morpholog1.96182553
20MP0002877_abnormal_melanocyte_morpholog1.91902609
21MP0000383_abnormal_hair_follicle1.78411243
22MP0001879_abnormal_lymphatic_vessel1.78019084
23MP0010352_gastrointestinal_tract_polyps1.77274640
24MP0005671_abnormal_response_to1.73017771
25MP0004808_abnormal_hematopoietic_stem1.71059835
26MP0002102_abnormal_ear_morphology1.67320567
27MP0000516_abnormal_urinary_system1.64124215
28MP0005367_renal/urinary_system_phenotyp1.64124215
29MP0004134_abnormal_chest_morphology1.57288883
30MP0000372_irregular_coat_pigmentation1.55613038
31MP0010234_abnormal_vibrissa_follicle1.54428584
32MP0000733_abnormal_muscle_development1.52827030
33MP0003646_muscle_fatigue1.49729543
34MP0006082_CNS_inflammation1.47853024
35MP0009785_altered_susceptibility_to1.45761172
36MP0000427_abnormal_hair_cycle1.43627716
37MP0003890_abnormal_embryonic-extraembry1.40999976
38MP0002723_abnormal_immune_serum1.40887622
39MP0003828_pulmonary_edema1.40006549
40MP0005503_abnormal_tendon_morphology1.38044289
41MP0003121_genomic_imprinting1.36832564
42MP0003656_abnormal_erythrocyte_physiolo1.36161920
43MP0003252_abnormal_bile_duct1.36149188
44MP0005646_abnormal_pituitary_gland1.35818239
45MP0003091_abnormal_cell_migration1.33719868
46MP0002420_abnormal_adaptive_immunity1.33269300
47MP0001819_abnormal_immune_cell1.31730238
48MP0010368_abnormal_lymphatic_system1.30387374
49MP0006054_spinal_hemorrhage1.29724120
50MP0002277_abnormal_respiratory_mucosa1.28678818
51MP0004484_altered_response_of1.27010017
52MP0010307_abnormal_tumor_latency1.26903961
53MP0000003_abnormal_adipose_tissue1.25943323
54MP0002132_abnormal_respiratory_system1.24461003
55MP0000767_abnormal_smooth_muscle1.24393940
56MP0003950_abnormal_plasma_membrane1.24115982
57MP0004947_skin_inflammation1.22388511
58MP0003303_peritoneal_inflammation1.21046136
59MP0000689_abnormal_spleen_morphology1.19440810
60MP0005387_immune_system_phenotype1.17713061
61MP0001790_abnormal_immune_system1.17713061
62MP0002998_abnormal_bone_remodeling1.17627825
63MP0002419_abnormal_innate_immunity1.17401641
64MP0009697_abnormal_copulation1.16468087
65MP0001851_eye_inflammation1.16046699
66MP0003763_abnormal_thymus_physiology1.15840778
67MP0001873_stomach_inflammation1.15620553
68MP0002925_abnormal_cardiovascular_devel1.14930358
69MP0001501_abnormal_sleep_pattern1.13959197
70MP0005409_darkened_coat_color1.12918341
71MP0001986_abnormal_taste_sensitivity1.12534576
72MP0000685_abnormal_immune_system1.11661406
73MP0000920_abnormal_myelination1.10866374
74MP0009703_decreased_birth_body1.09402057
75MP0009384_cardiac_valve_regurgitation1.08261690
76MP0003935_abnormal_craniofacial_develop1.07997086
77MP0003279_aneurysm1.07950193
78* MP0002398_abnormal_bone_marrow1.06967694
79MP0005171_absent_coat_pigmentation1.06511713
80MP0003566_abnormal_cell_adhesion1.06421755
81MP0002138_abnormal_hepatobiliary_system1.06212105
82MP0000465_gastrointestinal_hemorrhage1.06138021
83MP0005253_abnormal_eye_physiology1.06129107
84MP0003448_altered_tumor_morphology1.04311040
85MP0005551_abnormal_eye_electrophysiolog1.03882299
86* MP0000716_abnormal_immune_system1.02418534
87MP0000371_diluted_coat_color1.02081170
88MP0004197_abnormal_fetal_growth/weight/1.01777561
89MP0000703_abnormal_thymus_morphology1.00670136
90MP0000432_abnormal_head_morphology0.99775709
91MP0005647_abnormal_sex_gland0.99716062
92MP0010155_abnormal_intestine_physiology0.98578618
93MP0000613_abnormal_salivary_gland0.95675868
94MP0002928_abnormal_bile_duct0.95264308
95MP0009250_abnormal_appendicular_skeleto0.94710874
96MP0005025_abnormal_response_to0.94366490
97MP0003866_abnormal_defecation0.94023507
98MP0002095_abnormal_skin_pigmentation0.92748137
99MP0002933_joint_inflammation0.91426766
100MP0004272_abnormal_basement_membrane0.91424223
101MP0002108_abnormal_muscle_morphology0.91273401
102* MP0002722_abnormal_immune_system0.90902897
103MP0004142_abnormal_muscle_tone0.90313012
104MP0005275_abnormal_skin_tensile0.89964228
105MP0001784_abnormal_fluid_regulation0.89818834
106MP0004130_abnormal_muscle_cell0.89593701
107MP0003943_abnormal_hepatobiliary_system0.89523058
108MP0000015_abnormal_ear_pigmentation0.87352328
109MP0002896_abnormal_bone_mineralization0.86853461
110MP0002405_respiratory_system_inflammati0.86796856
111MP0003453_abnormal_keratinocyte_physiol0.86656524
112MP0008877_abnormal_DNA_methylation0.85981826
113MP0005388_respiratory_system_phenotype0.85964687
114MP0002133_abnormal_respiratory_system0.85964687
115MP0005623_abnormal_meninges_morphology0.85625831
116MP0001800_abnormal_humoral_immune0.85469958
117MP0005408_hypopigmentation0.85312562
118MP0004185_abnormal_adipocyte_glucose0.85192272
119MP0003937_abnormal_limbs/digits/tail_de0.85051413
120MP0001177_atelectasis0.83733328
121MP0002148_abnormal_hypersensitivity_rea0.82969662
122* MP0001845_abnormal_inflammatory_respons0.81645047
123MP0003786_premature_aging0.81389063
124MP0001915_intracranial_hemorrhage0.81275960
125MP0004883_abnormal_blood_vessel0.81019489
126MP0005187_abnormal_penis_morphology0.80888756
127MP0002168_other_aberrant_phenotype0.79855462
128MP0001485_abnormal_pinna_reflex0.78973758
129MP0009764_decreased_sensitivity_to0.78368634
130MP0001216_abnormal_epidermal_layer0.77682724
131MP0002088_abnormal_embryonic_growth/wei0.77498377
132MP0000627_abnormal_mammary_gland0.77368566
133MP0000428_abnormal_craniofacial_morphol0.77367832
134MP0008058_abnormal_DNA_repair0.77039045
135MP0000647_abnormal_sebaceous_gland0.76454561
136MP0003984_embryonic_growth_retardation0.76346056
137MP0003755_abnormal_palate_morphology0.75996866
138MP0002128_abnormal_blood_circulation0.75730559
139MP0002086_abnormal_extraembryonic_tissu0.74114461
140MP0004264_abnormal_extraembryonic_tissu0.74015570
141MP0002452_abnormal_antigen_presenting0.73806246
142MP0002115_abnormal_skeleton_extremities0.73666085
143MP0008961_abnormal_basal_metabolism0.73140047
144MP0002396_abnormal_hematopoietic_system0.73104409
145MP0005310_abnormal_salivary_gland0.73069574
146MP0003436_decreased_susceptibility_to0.73016827
147MP0002113_abnormal_skeleton_development0.72688151
148MP0002693_abnormal_pancreas_physiology0.72327696
149MP0010630_abnormal_cardiac_muscle0.71895354
150MP0009765_abnormal_xenobiotic_induced0.71761532
151* MP0005000_abnormal_immune_tolerance0.71434330
152MP0005167_abnormal_blood-brain_barrier0.71184789
153MP0002876_abnormal_thyroid_physiology0.70820741
154MP0009278_abnormal_bone_marrow0.70259692
155MP0001243_abnormal_dermal_layer0.70099849
156MP0002098_abnormal_vibrissa_morphology0.69804105
157MP0000470_abnormal_stomach_morphology0.67943126
158MP0002751_abnormal_autonomic_nervous0.67821050
159MP0002822_catalepsy0.66333524
160MP0000631_abnormal_neuroendocrine_gland0.66231205
161MP0004924_abnormal_behavior0.65146460
162MP0005386_behavior/neurological_phenoty0.65146460
163MP0005645_abnormal_hypothalamus_physiol0.64346276
164MP0008872_abnormal_physiological_respon0.63062407

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.83395988
2Abnormality of the nasal septum (HP:0000419)3.37575963
3Stomatitis (HP:0010280)3.11202791
4Papillary thyroid carcinoma (HP:0002895)3.10216868
5Genetic anticipation (HP:0003743)3.06752157
6Macroorchidism (HP:0000053)3.00811990
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.95623794
8Degeneration of the lateral corticospinal tracts (HP:0002314)2.95623794
9Absent frontal sinuses (HP:0002688)2.91306419
10Hyperventilation (HP:0002883)2.79089489
11Volvulus (HP:0002580)2.77654523
12Chronic hepatic failure (HP:0100626)2.74834142
13Neoplasm of the tracheobronchial system (HP:0100552)2.73092333
14T lymphocytopenia (HP:0005403)2.71779922
15Gaze-evoked nystagmus (HP:0000640)2.71220849
16Hypoplastic ischia (HP:0003175)2.69421607
17Lip pit (HP:0100267)2.67720497
18Abnormality of T cell number (HP:0011839)2.65525586
19Abnormality of the ischium (HP:0003174)2.64226459
20Pancreatic cysts (HP:0001737)2.63806147
21Progressive cerebellar ataxia (HP:0002073)2.60196670
22Febrile seizures (HP:0002373)2.48185555
23Short 4th metacarpal (HP:0010044)2.47544000
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.47544000
25Narrow palate (HP:0000189)2.45808421
26Fair hair (HP:0002286)2.44556429
27Hypochromic microcytic anemia (HP:0004840)2.43107391
28Alveolar cell carcinoma (HP:0006519)2.42448807
29Deep philtrum (HP:0002002)2.40788886
30Hypothermia (HP:0002045)2.40527074
31Abnormality of the renal cortex (HP:0011035)2.40454099
32Acute myeloid leukemia (HP:0004808)2.40235090
33Heterotopia (HP:0002282)2.40212155
34Thyroiditis (HP:0100646)2.39214284
35Submucous cleft hard palate (HP:0000176)2.37595315
36Aqueductal stenosis (HP:0002410)2.35471669
37Long eyelashes (HP:0000527)2.32298459
38Myositis (HP:0100614)2.30315112
39Depressed nasal tip (HP:0000437)2.30250078
40Recurrent bacterial skin infections (HP:0005406)2.26965208
41Hypoproteinemia (HP:0003075)2.26798980
42Abnormality of the corticospinal tract (HP:0002492)2.26562114
43Keratoconjunctivitis (HP:0001096)2.24749115
44Sensory axonal neuropathy (HP:0003390)2.23931478
45Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.23362675
46Generalized hypopigmentation of hair (HP:0011358)2.22703567
47Optic neuritis (HP:0100653)2.20196459
48Retrobulbar optic neuritis (HP:0100654)2.20196459
49Hyporeflexia of lower limbs (HP:0002600)2.19191034
50Sparse lateral eyebrow (HP:0005338)2.18151218
51Midline defect of the nose (HP:0004122)2.15669766
52Pancreatic fibrosis (HP:0100732)2.15086866
53True hermaphroditism (HP:0010459)2.14662799
54Thyroid carcinoma (HP:0002890)2.10611690
55Abnormality of B cell number (HP:0010975)2.09679625
56Tented upper lip vermilion (HP:0010804)2.07616794
57Short 1st metacarpal (HP:0010034)2.07002346
58Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.07002346
59Urethral obstruction (HP:0000796)2.02455818
60Astrocytoma (HP:0009592)2.02077136
61Abnormality of the astrocytes (HP:0100707)2.02077136
62Osteolytic defects of the phalanges of the hand (HP:0009771)2.00858761
63Osteolytic defects of the hand bones (HP:0009699)2.00858761
64Limited elbow extension (HP:0001377)2.00383081
65Abnormality of T cells (HP:0002843)1.98762705
66Long clavicles (HP:0000890)1.98481206
67Abnormality of eosinophils (HP:0001879)1.96834845
68Intestinal atresia (HP:0011100)1.96246992
69Severe combined immunodeficiency (HP:0004430)1.95633116
70Hepatoblastoma (HP:0002884)1.94687015
71Abnormality of the renal medulla (HP:0100957)1.94349571
72Abnormality of the frontal sinuses (HP:0002687)1.94255996
73Leukocytosis (HP:0001974)1.93658080
74Neoplasm of the adrenal cortex (HP:0100641)1.93410639
75Abnormality of chromosome stability (HP:0003220)1.92702119
76Aortic aneurysm (HP:0004942)1.92640878
77Curly hair (HP:0002212)1.92620890
78Abnormal hair whorl (HP:0010721)1.92556316
79Drooling (HP:0002307)1.92202340
80Absent speech (HP:0001344)1.91891066
81Glioma (HP:0009733)1.90879593
82Syringomyelia (HP:0003396)1.90452844
83Spinal cord lesions (HP:0100561)1.90452844
84Hypoplastic labia majora (HP:0000059)1.90348584
85Nephronophthisis (HP:0000090)1.90120115
86Hypoplastic iliac wings (HP:0002866)1.89789875
87Excessive salivation (HP:0003781)1.89634527
88Protruding tongue (HP:0010808)1.87936996
89Vertebral arch anomaly (HP:0008438)1.87878177
90Eosinophilia (HP:0001880)1.87563896
91Hamartoma of the eye (HP:0010568)1.86836353
92Elevated erythrocyte sedimentation rate (HP:0003565)1.86548284
93Renal cortical cysts (HP:0000803)1.86196821
94Tapered finger (HP:0001182)1.85584022
95Vitreoretinal degeneration (HP:0000655)1.85422861
96Ependymoma (HP:0002888)1.83742328
97Autoimmune hemolytic anemia (HP:0001890)1.82189541
98Chin dimple (HP:0010751)1.82095322
99Progressive inability to walk (HP:0002505)1.81946775
100Termporal pattern (HP:0011008)1.81823845
101Insidious onset (HP:0003587)1.81823845
102Recurrent cutaneous fungal infections (HP:0011370)1.81755308
103Chronic mucocutaneous candidiasis (HP:0002728)1.81755308
104Hematochezia (HP:0002573)1.80672916
105Recurrent abscess formation (HP:0002722)1.80533897
106Abnormality of incisor morphology (HP:0011063)1.80395971
107Tubulointerstitial nephritis (HP:0001970)1.79047664
108Toxemia of pregnancy (HP:0100603)1.77410607
109Abnormality of the 1st metacarpal (HP:0010009)1.76667472
110Spontaneous hematomas (HP:0007420)1.75871048
111Trigonocephaly (HP:0000243)1.75227185
112Abnormality of midbrain morphology (HP:0002418)1.74626810
113Molar tooth sign on MRI (HP:0002419)1.74626810
114Hypoplasia of the maxilla (HP:0000327)1.73044972
115Recurrent bronchitis (HP:0002837)1.72266668
116Hemoptysis (HP:0002105)1.69986568
117Asymmetry of the thorax (HP:0001555)1.69517781
118Increased number of teeth (HP:0011069)1.69338698
119Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.68725967
120Abnormality of the labia majora (HP:0012881)1.67770316
121Segmental peripheral demyelination/remyelination (HP:0003481)1.67014212
122B lymphocytopenia (HP:0010976)1.66744783
123Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66520088
124Low anterior hairline (HP:0000294)1.66329966
125Biliary tract neoplasm (HP:0100574)1.66029589
126Widely spaced teeth (HP:0000687)1.66014179
127Congenital stationary night blindness (HP:0007642)1.65999410
128Abnormality of the axillary hair (HP:0100134)1.64676463
129Abnormality of secondary sexual hair (HP:0009888)1.64676463
130Dynein arm defect of respiratory motile cilia (HP:0012255)1.63930970
131Absent/shortened dynein arms (HP:0200106)1.63930970
132Persistence of primary teeth (HP:0006335)1.63923712
133Transitional cell carcinoma of the bladder (HP:0006740)1.63909123
134Encephalitis (HP:0002383)1.63360544
135Exostoses (HP:0100777)1.62830887
136Medulloblastoma (HP:0002885)1.62752809
137Broad-based gait (HP:0002136)1.62710433
138Recurrent viral infections (HP:0004429)1.61760249
139Clubbing of toes (HP:0100760)1.60413397
140Dyskinesia (HP:0100660)1.60053889
141Cupped ear (HP:0000378)1.58368675
142Attenuation of retinal blood vessels (HP:0007843)1.57966545
143Thick eyebrow (HP:0000574)1.56372982
144Subacute progressive viral hepatitis (HP:0006572)1.55540034
145Prostate neoplasm (HP:0100787)1.53622010
146Anal stenosis (HP:0002025)1.52191306
147Truncal obesity (HP:0001956)1.51580209
148Exotropia (HP:0000577)1.51211205
149Skull defect (HP:0001362)1.50721224
150Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.50146229
151Autoimmune thrombocytopenia (HP:0001973)1.50143596
152Ectopic kidney (HP:0000086)1.49076306
153Short nail (HP:0001799)1.48872201
154Abnormality of the 4th metacarpal (HP:0010012)1.48688776
155Hypoplasia of the iris (HP:0007676)1.48405837
156Abnormality of the parietal bone (HP:0002696)1.48399690
157Decreased motor nerve conduction velocity (HP:0003431)1.47850429
158Orchitis (HP:0100796)1.47779587
159Obsessive-compulsive behavior (HP:0000722)1.46189547
160Abnormality of the distal phalanx of the thumb (HP:0009617)1.45961718
161Spondylolisthesis (HP:0003302)1.45715996
162Myocardial infarction (HP:0001658)1.45709252
163Delayed closure of the anterior fontanelle (HP:0001476)1.44681388
164Thoracolumbar scoliosis (HP:0002944)1.44094994
165Enlarged epiphyses (HP:0010580)1.43533875
166Recurrent fungal infections (HP:0002841)1.43512452
167Keratoconjunctivitis sicca (HP:0001097)1.42897647
168Tibial bowing (HP:0002982)1.42816049
169Disproportionate tall stature (HP:0001519)1.42733185
170Rectal prolapse (HP:0002035)1.41955197
171Onion bulb formation (HP:0003383)1.41425663
172Epiphyseal dysplasia (HP:0002656)1.39273708
173Stomach cancer (HP:0012126)1.39252343
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.38551626

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.24516076
2EPHA33.24107568
3LATS13.17686814
4TRIM282.84533865
5CDK122.80801346
6FGFR22.56785715
7EPHB12.37117222
8FGFR32.29612113
9MAP3K142.24312216
10CAMK1D2.22200326
11NUAK12.13401808
12CAMK1G2.12977122
13STK32.05654541
14SIK32.02208441
15SGK21.96290199
16TNIK1.85549745
17MST41.84126692
18MAP3K41.81866317
19ZAK1.80396566
20ERBB31.75854237
21BCR1.74783805
22WNK11.68704826
23ACVR1B1.68097702
24TRPM71.63728238
25BRD41.62647960
26BRSK21.61986923
27SGK31.61623693
28TEC1.59608026
29EIF2AK31.57528738
30AKT31.53422845
31GRK11.52021833
32CHUK1.51556759
33TXK1.51555520
34PIK3CG1.44148425
35SGK4941.40720334
36SGK2231.40720334
37PDGFRB1.38764508
38BLK1.35934198
39DMPK1.31672905
40CASK1.29177389
41STK391.28624663
42MELK1.28181953
43PAK31.22937653
44JAK31.22568533
45PINK11.18783025
46STK101.17073968
47SIK11.15831079
48INSRR1.15384555
49MAP3K21.15319677
50MAPK131.14946249
51WNK31.14648864
52BMPR21.10745908
53JAK11.10604256
54STK41.09395547
55ADRBK21.08155095
56CDK91.06640488
57MAP4K21.06457532
58BTK1.04314450
59NLK1.01791526
60CDK61.01791361
61OBSCN0.98124103
62PLK20.98094420
63ITK0.94476948
64PTK2B0.91914763
65OXSR10.91777176
66SYK0.91444105
67HIPK20.89829819
68PIK3CA0.89728677
69CAMKK20.87398385
70FER0.87334861
71IKBKE0.87133409
72NEK90.85568522
73PKN10.84433668
74TNK20.82580897
75BMPR1B0.81614053
76GRK60.81364790
77CSNK1A1L0.80620549
78YES10.76783564
79MKNK10.74867797
80RIPK40.73937069
81IKBKB0.73264545
82SGK10.73263148
83MARK30.71909257
84MAP4K10.71643292
85* MTOR0.71519868
86GSK3A0.70450145
87FES0.69886027
88RIPK10.69429097
89PRKCQ0.68629092
90PTK60.68315422
91LYN0.67020005
92MKNK20.66918371
93CLK10.66414833
94PRKCH0.65982337
95FGFR40.65347244
96STK240.64868579
97TGFBR20.64345194
98PIM10.63016305
99RPS6KB10.62451305
100ATM0.62295006
101MAP3K30.61184066
102IRAK20.59028209
103FGR0.58500986
104LCK0.57366481
105IRAK40.56944706
106MAP2K40.55426610
107NEK60.54930797
108KSR10.54635561
109PRKAA20.54452676
110MAPK100.53751816
111RPS6KA50.53193289
112ERBB40.51335194
113IRAK10.51023515
114MAP3K70.49907211
115FGFR10.49709325
116SRPK10.48548693
117TTN0.48523127
118PDGFRA0.47729340
119DYRK1A0.47629745
120PRKCE0.47593478
121STK110.47584399
122MARK20.47284152
123HCK0.46173961
124DYRK30.46005705
125EPHA40.44035194
126ABL10.43298701
127EGFR0.41219381
128CSNK1D0.40528828
129TYK20.40391998
130MAPK80.40186284
131INSR0.39972716
132MAPK10.39860207
133RPS6KA20.39856244
134MAP3K50.39401676
135GRK70.39327338
136RET0.39023466
137MAPK140.38977420
138CSK0.38259795
139ADRBK10.37674329
140JAK20.37510547
141ERBB20.37116137
142CDC42BPA0.35932251
143TAOK30.35616893
144PRKAA10.35589919
145IGF1R0.35047542

Predicted pathways (KEGG)

RankGene SetZ-score
1Dorso-ventral axis formation_Homo sapiens_hsa043201.95061781
2Circadian rhythm_Homo sapiens_hsa047101.69844201
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.57090761
4Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56756654
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.56618757
6Prostate cancer_Homo sapiens_hsa052151.53452229
7MicroRNAs in cancer_Homo sapiens_hsa052061.51329945
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50155391
9T cell receptor signaling pathway_Homo sapiens_hsa046601.45746363
10Adherens junction_Homo sapiens_hsa045201.44529478
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.44014452
12Chronic myeloid leukemia_Homo sapiens_hsa052201.36548607
13Graft-versus-host disease_Homo sapiens_hsa053321.34879418
14TGF-beta signaling pathway_Homo sapiens_hsa043501.33053538
15B cell receptor signaling pathway_Homo sapiens_hsa046621.32227447
16Transcriptional misregulation in cancer_Homo sapiens_hsa052021.30669274
17Pancreatic cancer_Homo sapiens_hsa052121.30066275
18ECM-receptor interaction_Homo sapiens_hsa045121.27827853
19Small cell lung cancer_Homo sapiens_hsa052221.27583773
20Fanconi anemia pathway_Homo sapiens_hsa034601.23445016
21Phototransduction_Homo sapiens_hsa047441.23386613
22RNA degradation_Homo sapiens_hsa030181.22148906
23Osteoclast differentiation_Homo sapiens_hsa043801.22036271
24Toxoplasmosis_Homo sapiens_hsa051451.20457486
25TNF signaling pathway_Homo sapiens_hsa046681.20117520
26Focal adhesion_Homo sapiens_hsa045101.18816368
27Hematopoietic cell lineage_Homo sapiens_hsa046401.18572300
28Type II diabetes mellitus_Homo sapiens_hsa049301.18323161
29Measles_Homo sapiens_hsa051621.17112631
30Renal cell carcinoma_Homo sapiens_hsa052111.16951583
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.16401202
32Caffeine metabolism_Homo sapiens_hsa002321.14550553
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14138745
34Viral myocarditis_Homo sapiens_hsa054161.13489529
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.13218837
36ErbB signaling pathway_Homo sapiens_hsa040121.11110335
37Endometrial cancer_Homo sapiens_hsa052131.11031354
38Prolactin signaling pathway_Homo sapiens_hsa049171.10634064
39Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10419685
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.10313129
41Linoleic acid metabolism_Homo sapiens_hsa005911.09900685
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09551115
43Leishmaniasis_Homo sapiens_hsa051401.09236308
44Allograft rejection_Homo sapiens_hsa053301.08729838
45Regulation of autophagy_Homo sapiens_hsa041401.08419823
46Proteoglycans in cancer_Homo sapiens_hsa052051.07680274
47FoxO signaling pathway_Homo sapiens_hsa040681.07665403
48Lysine degradation_Homo sapiens_hsa003101.07108309
49Insulin resistance_Homo sapiens_hsa049311.07007031
50Staphylococcus aureus infection_Homo sapiens_hsa051501.06655153
51Nitrogen metabolism_Homo sapiens_hsa009101.05794269
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04582167
53Ether lipid metabolism_Homo sapiens_hsa005651.04106873
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04053101
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.03414683
56Hepatitis B_Homo sapiens_hsa051611.03050506
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.02647415
58Type I diabetes mellitus_Homo sapiens_hsa049401.01457633
59Malaria_Homo sapiens_hsa051441.01305484
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01041531
61Axon guidance_Homo sapiens_hsa043601.00566156
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98221190
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97784360
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97707463
65Viral carcinogenesis_Homo sapiens_hsa052030.96988259
66Colorectal cancer_Homo sapiens_hsa052100.94060662
67Chemokine signaling pathway_Homo sapiens_hsa040620.93000758
68mTOR signaling pathway_Homo sapiens_hsa041500.91860107
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.91416850
70Acute myeloid leukemia_Homo sapiens_hsa052210.91341690
71Systemic lupus erythematosus_Homo sapiens_hsa053220.90619279
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90595663
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89479097
74MAPK signaling pathway_Homo sapiens_hsa040100.88098602
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87599337
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87293722
77Autoimmune thyroid disease_Homo sapiens_hsa053200.86217069
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86207301
79Primary immunodeficiency_Homo sapiens_hsa053400.85595779
80Inositol phosphate metabolism_Homo sapiens_hsa005620.85042879
81Pathways in cancer_Homo sapiens_hsa052000.84078485
82Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82157171
83Melanoma_Homo sapiens_hsa052180.81189410
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80545977
85Butanoate metabolism_Homo sapiens_hsa006500.80488696
86Nicotine addiction_Homo sapiens_hsa050330.80068024
87Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79620803
88Hippo signaling pathway_Homo sapiens_hsa043900.79296775
89Taste transduction_Homo sapiens_hsa047420.79140099
90Influenza A_Homo sapiens_hsa051640.78644419
91Amoebiasis_Homo sapiens_hsa051460.78128103
92Basal transcription factors_Homo sapiens_hsa030220.77874570
93HTLV-I infection_Homo sapiens_hsa051660.77541084
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.77062679
95Herpes simplex infection_Homo sapiens_hsa051680.76556284
96Hepatitis C_Homo sapiens_hsa051600.76253256
97Platelet activation_Homo sapiens_hsa046110.76153572
98Renin secretion_Homo sapiens_hsa049240.75305259
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75247197
100Glioma_Homo sapiens_hsa052140.74575616
101Long-term depression_Homo sapiens_hsa047300.74388376
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74142614
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.73683948
104Non-small cell lung cancer_Homo sapiens_hsa052230.73551994
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73036477
106Olfactory transduction_Homo sapiens_hsa047400.72577578
107Antigen processing and presentation_Homo sapiens_hsa046120.72242803
108ABC transporters_Homo sapiens_hsa020100.70216609
109Wnt signaling pathway_Homo sapiens_hsa043100.69946275
110mRNA surveillance pathway_Homo sapiens_hsa030150.69598181
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68788390
112Choline metabolism in cancer_Homo sapiens_hsa052310.68779805
113Basal cell carcinoma_Homo sapiens_hsa052170.68731461
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.68346216
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68015020
116Morphine addiction_Homo sapiens_hsa050320.67865887
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67820720
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67739495
119Non-homologous end-joining_Homo sapiens_hsa034500.67503516
120Salmonella infection_Homo sapiens_hsa051320.66765183
121Serotonergic synapse_Homo sapiens_hsa047260.65884011
122Notch signaling pathway_Homo sapiens_hsa043300.65502948
123Legionellosis_Homo sapiens_hsa051340.64104090
124Fatty acid biosynthesis_Homo sapiens_hsa000610.63281605
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62714684
126Tuberculosis_Homo sapiens_hsa051520.62179044
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61850922
128African trypanosomiasis_Homo sapiens_hsa051430.61329017
129Ovarian steroidogenesis_Homo sapiens_hsa049130.61118185
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60605259
131Rap1 signaling pathway_Homo sapiens_hsa040150.60468204
132AMPK signaling pathway_Homo sapiens_hsa041520.60366932
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59630136
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59217310
135Ras signaling pathway_Homo sapiens_hsa040140.58775608
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.58151369
137cAMP signaling pathway_Homo sapiens_hsa040240.57983197
138Homologous recombination_Homo sapiens_hsa034400.56258840
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55197091
140Amphetamine addiction_Homo sapiens_hsa050310.54111040
141Asthma_Homo sapiens_hsa053100.51376196
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49902284
143Circadian entrainment_Homo sapiens_hsa047130.48254700
144Sulfur metabolism_Homo sapiens_hsa009200.47326152

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »