RBSN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.73175719
2monoubiquitinated protein deubiquitination (GO:0035520)4.55861520
3vitamin transmembrane transport (GO:0035461)4.33878157
4presynaptic membrane assembly (GO:0097105)4.19907233
5pyrimidine nucleobase catabolic process (GO:0006208)4.07130726
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.98846806
7gamma-aminobutyric acid transport (GO:0015812)3.90729955
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77283517
9presynaptic membrane organization (GO:0097090)3.71111662
10regulation of spindle organization (GO:0090224)3.59941802
11regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41227535
12ionotropic glutamate receptor signaling pathway (GO:0035235)3.39317673
13neuron recognition (GO:0008038)3.37636871
14regulation of synaptic vesicle exocytosis (GO:2000300)3.28780600
15locomotory exploration behavior (GO:0035641)3.26770725
16mechanosensory behavior (GO:0007638)3.26155356
17positive regulation of synapse maturation (GO:0090129)3.25946366
18negative regulation of synaptic transmission, GABAergic (GO:0032229)3.25338985
19behavioral response to nicotine (GO:0035095)3.23231406
20nucleobase catabolic process (GO:0046113)3.20776247
21limb bud formation (GO:0060174)3.19371016
22negative regulation of cytosolic calcium ion concentration (GO:0051481)3.17415704
23synaptic transmission, glutamatergic (GO:0035249)3.16254018
24mitotic metaphase plate congression (GO:0007080)3.13827026
25cerebral cortex radially oriented cell migration (GO:0021799)3.12909166
26positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.11728750
27regulation of mitotic spindle organization (GO:0060236)3.07151752
28synaptic vesicle maturation (GO:0016188)3.06273595
29intestinal epithelial cell development (GO:0060576)3.04459604
30positive regulation of chromosome segregation (GO:0051984)3.03685637
31lung-associated mesenchyme development (GO:0060484)3.02138778
32glutamate receptor signaling pathway (GO:0007215)2.99061551
33transmission of nerve impulse (GO:0019226)2.98154811
34regulation of RNA export from nucleus (GO:0046831)2.97029401
35neurotransmitter-gated ion channel clustering (GO:0072578)2.95960238
36membrane depolarization during action potential (GO:0086010)2.93319369
37behavioral response to ethanol (GO:0048149)2.92623229
38synapse assembly (GO:0007416)2.90384890
39regulation of synaptic vesicle transport (GO:1902803)2.88834672
40positive regulation of macroautophagy (GO:0016239)2.88420163
41response to pheromone (GO:0019236)2.87024159
42central nervous system projection neuron axonogenesis (GO:0021952)2.82950397
43head development (GO:0060322)2.80860274
44regulation of synapse structural plasticity (GO:0051823)2.80158196
45synaptic vesicle docking involved in exocytosis (GO:0016081)2.78312817
46axon ensheathment in central nervous system (GO:0032291)2.78027804
47central nervous system myelination (GO:0022010)2.78027804
48regulation of establishment of cell polarity (GO:2000114)2.77964747
49establishment of mitochondrion localization (GO:0051654)2.77654286
50establishment of nucleus localization (GO:0040023)2.77431213
51spindle assembly involved in mitosis (GO:0090307)2.75693814
52GMP metabolic process (GO:0046037)2.75649138
53regulation of respiratory system process (GO:0044065)2.74963584
54neuron-neuron synaptic transmission (GO:0007270)2.74155647
55negative regulation of astrocyte differentiation (GO:0048712)2.72147246
56regulation of nucleobase-containing compound transport (GO:0032239)2.71168181
57regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70878718
58purine nucleobase biosynthetic process (GO:0009113)2.70492310
59response to auditory stimulus (GO:0010996)2.70279373
60protein K48-linked deubiquitination (GO:0071108)2.70177868
61cytoplasmic mRNA processing body assembly (GO:0033962)2.69728407
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68081185
63layer formation in cerebral cortex (GO:0021819)2.67844880
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.67601486
65glutamate secretion (GO:0014047)2.67288068
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67059809
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.67059809
68regulation of translation, ncRNA-mediated (GO:0045974)2.67059809
69negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67053987
70snRNA transcription (GO:0009301)2.66950221
71negative regulation of fibroblast apoptotic process (GO:2000270)2.66447996
72G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65902523
73adult walking behavior (GO:0007628)2.64985661
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.64910439
75synaptic vesicle exocytosis (GO:0016079)2.62274370
76positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.60402567
77positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60402567
78positive regulation of mitotic sister chromatid separation (GO:1901970)2.60402567
79microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.58405498
80nuclear pore complex assembly (GO:0051292)2.57996963
81nuclear pore organization (GO:0006999)2.57626564
82regulation of translational termination (GO:0006449)2.56990065
83proline transport (GO:0015824)2.56701589
84calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.56609261
85C4-dicarboxylate transport (GO:0015740)2.55535455
86regulation of neurotransmitter uptake (GO:0051580)2.55449271
87histone H2A monoubiquitination (GO:0035518)2.55262485
88regulation of clathrin-mediated endocytosis (GO:2000369)2.54697684
89negative regulation of neurotransmitter transport (GO:0051589)2.54441154
90cAMP catabolic process (GO:0006198)2.52861686
91synapse organization (GO:0050808)2.52289563
92cyclic nucleotide catabolic process (GO:0009214)2.51819488
93retinal ganglion cell axon guidance (GO:0031290)2.51573447
94regulation of synapse maturation (GO:0090128)2.51548983
95regulation of hippo signaling (GO:0035330)2.51327006
96righting reflex (GO:0060013)2.50247070
97negative regulation of hormone biosynthetic process (GO:0032353)2.50151482
98negative regulation of hormone metabolic process (GO:0032351)2.50151482
99regulation of glutamate receptor signaling pathway (GO:1900449)2.50130753
100spinal cord development (GO:0021510)2.49639260
101neuromuscular process controlling balance (GO:0050885)2.48687468
102central nervous system neuron axonogenesis (GO:0021955)2.48411376
103innervation (GO:0060384)2.47344943
104somite development (GO:0061053)2.46128753
105nonmotile primary cilium assembly (GO:0035058)2.45836874
106negative regulation of oligodendrocyte differentiation (GO:0048715)2.45654432
107cerebellar Purkinje cell differentiation (GO:0021702)2.43335254
108neuromuscular synaptic transmission (GO:0007274)2.42482980
109neuronal ion channel clustering (GO:0045161)2.41863142
110vesicle transport along microtubule (GO:0047496)2.41823444
111regulation of dendritic spine morphogenesis (GO:0061001)2.40723270
112protein K11-linked deubiquitination (GO:0035871)2.39584068
113serotonin metabolic process (GO:0042428)2.38679081
114startle response (GO:0001964)2.38569158
115neuronal action potential (GO:0019228)2.38142181
116limb development (GO:0060173)2.37487830
117appendage development (GO:0048736)2.37487830
118regulation of collateral sprouting (GO:0048670)2.37479652
119regulation of sister chromatid cohesion (GO:0007063)2.37446237
120positive regulation of synapse assembly (GO:0051965)2.36858606
121glycosphingolipid biosynthetic process (GO:0006688)2.36543571
122regulation of synaptic transmission, GABAergic (GO:0032228)2.35896822
123regulation of axon guidance (GO:1902667)2.34720639
124detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.34626269
125regulation of voltage-gated calcium channel activity (GO:1901385)2.34362964
126mitotic chromosome condensation (GO:0007076)2.33201642
127negative regulation of dendrite morphogenesis (GO:0050774)2.32625956
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.31959482
129adult behavior (GO:0030534)2.31601428
130neuron cell-cell adhesion (GO:0007158)2.31170384
131regulation of establishment or maintenance of cell polarity (GO:0032878)2.30331213
132primary amino compound metabolic process (GO:1901160)2.30316355
133gamma-aminobutyric acid signaling pathway (GO:0007214)2.30160983
134vocalization behavior (GO:0071625)2.30067584
135regulation of neuronal synaptic plasticity (GO:0048168)2.27756937
136dendritic spine morphogenesis (GO:0060997)2.27717742
137synaptic vesicle endocytosis (GO:0048488)2.27378821
138pre-miRNA processing (GO:0031054)2.26504801
139auditory behavior (GO:0031223)2.25518963
140metaphase plate congression (GO:0051310)2.25466745
141cerebellar granule cell differentiation (GO:0021707)2.23795381
142cell migration in hindbrain (GO:0021535)2.23450152
143centrosome duplication (GO:0051298)2.20557622
144macroautophagy (GO:0016236)2.18951103
145regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.18265189
146nucleobase biosynthetic process (GO:0046112)2.18075063
147positive regulation of vesicle fusion (GO:0031340)2.17480431
148regulation of chromosome segregation (GO:0051983)2.17425694
149exploration behavior (GO:0035640)2.16840821
150axonal fasciculation (GO:0007413)2.16672175
151ribosome assembly (GO:0042255)2.15662391
152microtubule depolymerization (GO:0007019)2.14331109
153mitotic sister chromatid segregation (GO:0000070)2.13593029
154inner cell mass cell proliferation (GO:0001833)2.12909068
155regulation of long-term neuronal synaptic plasticity (GO:0048169)2.12408496
156glucocorticoid receptor signaling pathway (GO:0042921)2.12351274
157neurotransmitter secretion (GO:0007269)2.12075779
158autophagic vacuole assembly (GO:0000045)2.10613165
159peptidyl-arginine methylation (GO:0018216)2.10575450
160peptidyl-arginine N-methylation (GO:0035246)2.10575450
161negative regulation of dendrite development (GO:2000171)2.10054266
162peptidyl-threonine dephosphorylation (GO:0035970)2.09875317
163protein localization to synapse (GO:0035418)2.09292398
164hippo signaling (GO:0035329)2.08544813
165sister chromatid segregation (GO:0000819)2.08339374
166protein demethylation (GO:0006482)2.08041617
167protein dealkylation (GO:0008214)2.08041617
168neuronal action potential propagation (GO:0019227)2.07556726
169regulation of ARF protein signal transduction (GO:0032012)2.07477010
170spindle checkpoint (GO:0031577)2.07455064
171histone demethylation (GO:0016577)2.06128932
172pore complex assembly (GO:0046931)2.05894344
173neuromuscular process (GO:0050905)2.05865444
174glial cell proliferation (GO:0014009)2.05633652
175dendrite morphogenesis (GO:0048813)2.05607776
176prepulse inhibition (GO:0060134)2.05293607

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.39592539
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.12654547
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.10842970
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.08840154
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.84015689
6KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75927970
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63189575
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.45853292
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.39418831
10EZH2_22144423_ChIP-Seq_EOC_Human2.12752961
11TAF15_26573619_Chip-Seq_HEK293_Human2.11302197
12ZNF274_21170338_ChIP-Seq_K562_Hela2.04870429
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99496194
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99395713
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95923347
16SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.93240767
17RARB_27405468_Chip-Seq_BRAIN_Mouse1.93043384
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.90987141
19PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88274659
20E2F7_22180533_ChIP-Seq_HELA_Human1.85412142
21IGF1R_20145208_ChIP-Seq_DFB_Human1.84392979
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.82532452
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.78127853
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.75014594
25CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72375867
26P300_19829295_ChIP-Seq_ESCs_Human1.71417200
27REST_21632747_ChIP-Seq_MESCs_Mouse1.70654568
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.68725032
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67023681
30HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.66112515
31EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56130282
32ZNF263_19887448_ChIP-Seq_K562_Human1.54647346
33GBX2_23144817_ChIP-Seq_PC3_Human1.53504876
34TP53_16413492_ChIP-PET_HCT116_Human1.53420314
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53289426
36ER_23166858_ChIP-Seq_MCF-7_Human1.52140202
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.47991155
38PKCTHETA_26484144_Chip-Seq_BREAST_Human1.47735109
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.47489005
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.45906904
41TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44847964
42FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.44820661
43VDR_22108803_ChIP-Seq_LS180_Human1.44496577
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42959839
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.42690308
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40450337
47STAT3_23295773_ChIP-Seq_U87_Human1.39687194
48AHR_22903824_ChIP-Seq_MCF-7_Human1.38287808
49SMAD4_21799915_ChIP-Seq_A2780_Human1.34722965
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34393722
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34311675
52AR_21909140_ChIP-Seq_LNCAP_Human1.33562655
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32116962
54TBX3_20139965_ChIP-Seq_MESCs_Mouse1.29642035
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29028123
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.27886139
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26869466
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26712113
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26711818
60TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26679865
61UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26504419
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26054029
63CBP_20019798_ChIP-Seq_JUKART_Human1.26054029
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.25966936
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25299023
66ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24827126
67SOX9_26525672_Chip-Seq_HEART_Mouse1.24636804
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.24630018
69RUNX2_22187159_ChIP-Seq_PCA_Human1.23785338
70OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22898474
71KDM2B_26808549_Chip-Seq_K562_Human1.22070255
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20985305
73TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20985305
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20772181
75WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20547301
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.20527778
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.19827923
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.19604924
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19556322
80HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19371008
81EWS_26573619_Chip-Seq_HEK293_Human1.16623890
82BCAT_22108803_ChIP-Seq_LS180_Human1.16070720
83AR_19668381_ChIP-Seq_PC3_Human1.15783582
84TCF4_23295773_ChIP-Seq_U87_Human1.14126168
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14083418
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.13628689
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11844626
88RXR_22108803_ChIP-Seq_LS180_Human1.11454065
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11136784
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.10402574
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09960054
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09807479
93FUS_26573619_Chip-Seq_HEK293_Human1.09351069
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.08602858
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08457730
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08415845
97FLI1_21867929_ChIP-Seq_TH2_Mouse1.07535813
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07197806
99JARID2_20064375_ChIP-Seq_MESCs_Mouse1.07196926
100CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07138863
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06933261
102RNF2_27304074_Chip-Seq_NSC_Mouse1.05600328
103SMAD3_21741376_ChIP-Seq_ESCs_Human1.05468363
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05104764
105JUN_21703547_ChIP-Seq_K562_Human1.05083961
106RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04682356
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04520542
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04520542
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04512988
110CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04289886
111LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04154426
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03822938
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.03508918
114CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02497127
115RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01147575
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01104956
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00586940
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00099167
119TCF4_22108803_ChIP-Seq_LS180_Human0.98848161
120AR_21572438_ChIP-Seq_LNCaP_Human0.98470414
121SMAD3_21741376_ChIP-Seq_EPCs_Human0.98397544
122KDM2B_26808549_Chip-Seq_REH_Human0.97777108
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97107664
124NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96319597
125NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96213852
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96210092
127YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94620336
128AR_25329375_ChIP-Seq_VCAP_Human0.93043394
129P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92892679
130DROSHA_22980978_ChIP-Seq_HELA_Human0.92007766
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91464830
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.91116040
133TET1_21490601_ChIP-Seq_MESCs_Mouse0.91051485
134ELK4_26923725_Chip-Seq_MESODERM_Mouse0.90488545
135WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89986322
136MTF2_20144788_ChIP-Seq_MESCs_Mouse0.89767049
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89549048
138TP63_19390658_ChIP-ChIP_HaCaT_Human0.89414173
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88967700
140EZH2_27304074_Chip-Seq_ESCs_Mouse0.88720936
141PIAS1_25552417_ChIP-Seq_VCAP_Human0.87821026
142GATA1_26923725_Chip-Seq_HPCs_Mouse0.87516597
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87403389

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.67802562
2MP0003123_paternal_imprinting2.72966478
3MP0003787_abnormal_imprinting2.62248991
4MP0000569_abnormal_digit_pigmentation2.50636575
5MP0003635_abnormal_synaptic_transmissio2.24813347
6MP0002102_abnormal_ear_morphology2.21152378
7MP0002877_abnormal_melanocyte_morpholog2.19542597
8MP0004270_analgesia2.04708792
9MP0008877_abnormal_DNA_methylation2.04430134
10MP0003121_genomic_imprinting1.96074355
11MP0010307_abnormal_tumor_latency1.80292367
12MP0001299_abnormal_eye_distance/1.77048271
13MP0002822_catalepsy1.75951343
14MP0008438_abnormal_cutaneous_collagen1.75549586
15MP0003111_abnormal_nucleus_morphology1.72815161
16MP0000631_abnormal_neuroendocrine_gland1.71039639
17MP0009046_muscle_twitch1.69870222
18MP0002063_abnormal_learning/memory/cond1.69689763
19MP0003122_maternal_imprinting1.69075651
20MP0005076_abnormal_cell_differentiation1.68888691
21MP0009780_abnormal_chondrocyte_physiolo1.67827981
22MP0001529_abnormal_vocalization1.66920633
23MP0002734_abnormal_mechanical_nocicepti1.64411984
24MP0010234_abnormal_vibrissa_follicle1.63331927
25MP0005551_abnormal_eye_electrophysiolog1.60348213
26MP0003880_abnormal_central_pattern1.59985178
27MP0006276_abnormal_autonomic_nervous1.59093049
28MP0002735_abnormal_chemical_nociception1.57969409
29MP0004885_abnormal_endolymph1.55896074
30MP0000427_abnormal_hair_cycle1.55072070
31MP0000778_abnormal_nervous_system1.49017786
32MP0000537_abnormal_urethra_morphology1.48110047
33MP0002064_seizures1.45471769
34MP0001486_abnormal_startle_reflex1.44293659
35MP0002163_abnormal_gland_morphology1.42691655
36MP0003136_yellow_coat_color1.42280635
37MP0002234_abnormal_pharynx_morphology1.37408169
38MP0000013_abnormal_adipose_tissue1.37375958
39MP0004142_abnormal_muscle_tone1.36446498
40MP0001502_abnormal_circadian_rhythm1.35421869
41MP0003693_abnormal_embryo_hatching1.35082263
42MP0002638_abnormal_pupillary_reflex1.33205096
43MP0000015_abnormal_ear_pigmentation1.32305466
44MP0002909_abnormal_adrenal_gland1.31739045
45MP0001501_abnormal_sleep_pattern1.30734751
46MP0002572_abnormal_emotion/affect_behav1.29989066
47MP0005253_abnormal_eye_physiology1.28535293
48MP0004811_abnormal_neuron_physiology1.27003613
49MP0002184_abnormal_innervation1.26080291
50MP0001188_hyperpigmentation1.22055688
51MP0003890_abnormal_embryonic-extraembry1.21146725
52MP0005171_absent_coat_pigmentation1.20530347
53MP0005248_abnormal_Harderian_gland1.20192526
54MP0001730_embryonic_growth_arrest1.18994302
55MP0008995_early_reproductive_senescence1.18047856
56MP0000733_abnormal_muscle_development1.15480472
57MP0003077_abnormal_cell_cycle1.14867377
58MP0003646_muscle_fatigue1.14475821
59MP0009745_abnormal_behavioral_response1.14169643
60MP0001968_abnormal_touch/_nociception1.13703648
61MP0005646_abnormal_pituitary_gland1.12988742
62MP0000003_abnormal_adipose_tissue1.10597884
63MP0000647_abnormal_sebaceous_gland1.09933376
64MP0004133_heterotaxia1.09655898
65MP0009703_decreased_birth_body1.08843789
66MP0004742_abnormal_vestibular_system1.07506486
67MP0002752_abnormal_somatic_nervous1.07178433
68MP0003861_abnormal_nervous_system1.06671091
69MP0000955_abnormal_spinal_cord1.06328082
70MP0002152_abnormal_brain_morphology1.05058571
71MP0008961_abnormal_basal_metabolism1.04195257
72MP0008569_lethality_at_weaning1.03787781
73MP0002084_abnormal_developmental_patter1.03684391
74MP0005380_embryogenesis_phenotype1.03042238
75MP0001672_abnormal_embryogenesis/_devel1.03042238
76MP0008007_abnormal_cellular_replicative1.02633815
77MP0010094_abnormal_chromosome_stability1.01397881
78MP0002272_abnormal_nervous_system1.00858602
79MP0003755_abnormal_palate_morphology1.00745227
80MP0004185_abnormal_adipocyte_glucose1.00374996
81MP0003632_abnormal_nervous_system1.00371472
82MP0008057_abnormal_DNA_replication1.00157210
83MP0003938_abnormal_ear_development0.99318661
84MP0006292_abnormal_olfactory_placode0.98933223
85MP0001177_atelectasis0.98754491
86MP0000428_abnormal_craniofacial_morphol0.98672240
87MP0000350_abnormal_cell_proliferation0.98241521
88MP0000049_abnormal_middle_ear0.97756907
89MP0004233_abnormal_muscle_weight0.97557100
90MP0005623_abnormal_meninges_morphology0.97457873
91MP0005645_abnormal_hypothalamus_physiol0.97141707
92MP0001984_abnormal_olfaction0.96601769
93MP0003045_fibrosis0.96300044
94MP0001986_abnormal_taste_sensitivity0.96212742
95MP0005257_abnormal_intraocular_pressure0.95101017
96MP0003935_abnormal_craniofacial_develop0.94415028
97MP0002882_abnormal_neuron_morphology0.92862038
98MP0003937_abnormal_limbs/digits/tail_de0.92860442
99MP0002733_abnormal_thermal_nociception0.92500187
100MP0005499_abnormal_olfactory_system0.91865254
101MP0005394_taste/olfaction_phenotype0.91865254
102MP0005503_abnormal_tendon_morphology0.91688861
103MP0002085_abnormal_embryonic_tissue0.91202657
104MP0002088_abnormal_embryonic_growth/wei0.91141982
105MP0001346_abnormal_lacrimal_gland0.90685633
106MP0004145_abnormal_muscle_electrophysio0.90602840
107MP0003984_embryonic_growth_retardation0.90562750
108MP0002938_white_spotting0.89955478
109MP0005187_abnormal_penis_morphology0.89866542
110MP0004858_abnormal_nervous_system0.89184802
111MP0004130_abnormal_muscle_cell0.88437754
112MP0003718_maternal_effect0.88423161
113MP0000026_abnormal_inner_ear0.88372710
114MP0002229_neurodegeneration0.88098233
115MP0001697_abnormal_embryo_size0.87758102
116MP0001293_anophthalmia0.87450813
117MP0002067_abnormal_sensory_capabilities0.87173362
118MP0005379_endocrine/exocrine_gland_phen0.87144236
119MP0009672_abnormal_birth_weight0.86891920
120MP0003634_abnormal_glial_cell0.85852839
121MP0001970_abnormal_pain_threshold0.85500367
122MP0003633_abnormal_nervous_system0.85433591
123MP0004147_increased_porphyrin_level0.85271558
124MP0005386_behavior/neurological_phenoty0.85174108
125MP0004924_abnormal_behavior0.85174108
126MP0005195_abnormal_posterior_eye0.84803049
127MP0001963_abnormal_hearing_physiology0.84335081
128MP0000383_abnormal_hair_follicle0.83104299
129MP0005423_abnormal_somatic_nervous0.82874730
130MP0010386_abnormal_urinary_bladder0.82800265
131MP0002653_abnormal_ependyma_morphology0.82416373
132MP0001440_abnormal_grooming_behavior0.82260319
133MP0003115_abnormal_respiratory_system0.82034911
134MP0005391_vision/eye_phenotype0.82021715
135MP0004043_abnormal_pH_regulation0.81901259
136MP0002066_abnormal_motor_capabilities/c0.81182221
137MP0010678_abnormal_skin_adnexa0.80292656
138MP0006072_abnormal_retinal_apoptosis0.80099992
139MP0003690_abnormal_glial_cell0.78873360
140MP0002086_abnormal_extraembryonic_tissu0.78829973
141MP0001324_abnormal_eye_pigmentation0.77346194
142MP0002751_abnormal_autonomic_nervous0.76013756
143MP0003385_abnormal_body_wall0.75545955
144MP0002009_preneoplasia0.73810182
145MP0000747_muscle_weakness0.73750337
146MP0002736_abnormal_nociception_after0.72055385
147MP0003119_abnormal_digestive_system0.71647985
148MP0003631_nervous_system_phenotype0.67794247
149MP0002557_abnormal_social/conspecific_i0.67677346

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.07212833
2Abnormality of the labia minora (HP:0012880)3.25938937
3Abnormality of the lower motor neuron (HP:0002366)3.13144857
4Focal motor seizures (HP:0011153)3.12618238
5Pancreatic cysts (HP:0001737)2.77033295
6Premature rupture of membranes (HP:0001788)2.73934890
7Atonic seizures (HP:0010819)2.69877816
8True hermaphroditism (HP:0010459)2.69239281
9Bundle branch block (HP:0011710)2.62786348
10Absent speech (HP:0001344)2.62062812
11Gaze-evoked nystagmus (HP:0000640)2.59352928
12Abnormality of midbrain morphology (HP:0002418)2.59214042
13Molar tooth sign on MRI (HP:0002419)2.59214042
14Shoulder girdle muscle weakness (HP:0003547)2.58064096
15Papillary thyroid carcinoma (HP:0002895)2.55120997
16Lissencephaly (HP:0001339)2.54069702
17Shallow orbits (HP:0000586)2.51303455
18Limb dystonia (HP:0002451)2.48505321
19Gait imbalance (HP:0002141)2.47286072
20Hemiparesis (HP:0001269)2.46028757
21Termporal pattern (HP:0011008)2.42685123
22Insidious onset (HP:0003587)2.42685123
23Nephronophthisis (HP:0000090)2.41868591
24Focal seizures (HP:0007359)2.36936236
25Type II lissencephaly (HP:0007260)2.33223558
26Mutism (HP:0002300)2.32279493
27Visual hallucinations (HP:0002367)2.32122098
28Pancreatic fibrosis (HP:0100732)2.29322883
29Dialeptic seizures (HP:0011146)2.28652397
30Birth length less than 3rd percentile (HP:0003561)2.28571431
31Nephrogenic diabetes insipidus (HP:0009806)2.26401600
32Pheochromocytoma (HP:0002666)2.25045902
33Pelvic girdle muscle weakness (HP:0003749)2.21584230
34Abnormality of the renal medulla (HP:0100957)2.21102932
35Generalized tonic-clonic seizures (HP:0002069)2.18763470
36Wrist flexion contracture (HP:0001239)2.18269468
37Drooling (HP:0002307)2.18226507
38Excessive salivation (HP:0003781)2.18226507
39Medial flaring of the eyebrow (HP:0010747)2.17035329
40Pachygyria (HP:0001302)2.16788139
41Cerebellar dysplasia (HP:0007033)2.16197877
42Facial hemangioma (HP:0000329)2.15945168
43Tetraplegia (HP:0002445)2.15141155
44Epileptiform EEG discharges (HP:0011182)2.10625779
45Subacute progressive viral hepatitis (HP:0006572)2.09319614
46EEG with generalized epileptiform discharges (HP:0011198)2.08942822
47Hypsarrhythmia (HP:0002521)2.08393145
48Hepatoblastoma (HP:0002884)2.08276612
49Shawl scrotum (HP:0000049)2.07893971
50High anterior hairline (HP:0009890)2.05299421
51Inability to walk (HP:0002540)2.04521115
52Congenital primary aphakia (HP:0007707)2.03712592
53Exotropia (HP:0000577)2.03554982
54Megalencephaly (HP:0001355)2.00793569
55Poor coordination (HP:0002370)2.00495626
56Fatigue (HP:0012378)2.00178065
57Abnormality of the renal cortex (HP:0011035)1.99563267
58Chronic hepatic failure (HP:0100626)1.99280718
59Abnormality of the aortic arch (HP:0012303)1.98128720
60Intestinal atresia (HP:0011100)1.97736072
61Impaired smooth pursuit (HP:0007772)1.97511345
62Neoplasm of the adrenal cortex (HP:0100641)1.97447498
63Progressive inability to walk (HP:0002505)1.94793425
64Abnormality of the ischium (HP:0003174)1.94254492
65Specific learning disability (HP:0001328)1.93969489
66Microglossia (HP:0000171)1.93050604
67Spinal muscular atrophy (HP:0007269)1.92498473
68Sparse lateral eyebrow (HP:0005338)1.91737443
69Abnormality of the musculature of the pelvis (HP:0001469)1.90932999
70Abnormality of the hip-girdle musculature (HP:0001445)1.90932999
71Aqueductal stenosis (HP:0002410)1.89156228
72Genital tract atresia (HP:0001827)1.89020203
73Fetal akinesia sequence (HP:0001989)1.87619890
74Vaginal atresia (HP:0000148)1.87076991
75Cerebral aneurysm (HP:0004944)1.85819478
76Oligodactyly (HP:0012165)1.83375685
77Progressive cerebellar ataxia (HP:0002073)1.82752747
78Optic nerve hypoplasia (HP:0000609)1.82385859
79Neuroendocrine neoplasm (HP:0100634)1.80582270
80Urinary bladder sphincter dysfunction (HP:0002839)1.79330167
81Ankle contracture (HP:0006466)1.79066650
82Hypoplasia of the corpus callosum (HP:0002079)1.78378933
83Gastroesophageal reflux (HP:0002020)1.78288696
84Segmental peripheral demyelination/remyelination (HP:0003481)1.77535307
85Partial agenesis of the corpus callosum (HP:0001338)1.77482521
86Absent eyebrow (HP:0002223)1.76543312
87Midline defect of the nose (HP:0004122)1.74968098
88Hip dysplasia (HP:0001385)1.74829218
89Astrocytoma (HP:0009592)1.74071182
90Abnormality of the astrocytes (HP:0100707)1.74071182
91Pointed chin (HP:0000307)1.73837466
92Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72974781
93Hypoplasia of the brainstem (HP:0002365)1.72974781
94Spastic gait (HP:0002064)1.72222177
95Concave nail (HP:0001598)1.72020147
96Cystic liver disease (HP:0006706)1.71144867
97Genetic anticipation (HP:0003743)1.70127030
98Myokymia (HP:0002411)1.70112762
99Aplasia/Hypoplasia of the sternum (HP:0006714)1.69829128
100Colon cancer (HP:0003003)1.69636274
101Retinal dysplasia (HP:0007973)1.69468807
102Cervical subluxation (HP:0003308)1.68598189
103Abnormality of chromosome segregation (HP:0002916)1.68595534
104Aplasia/Hypoplasia of the tongue (HP:0010295)1.68322625
105Abnormality of ocular smooth pursuit (HP:0000617)1.68101261
106Patellar aplasia (HP:0006443)1.67665831
107Cutaneous finger syndactyly (HP:0010554)1.67036711
108Urinary urgency (HP:0000012)1.66932126
109Enlarged penis (HP:0000040)1.66214191
110Genu recurvatum (HP:0002816)1.65587593
111Cerebral hypomyelination (HP:0006808)1.64821672
112Cystic hygroma (HP:0000476)1.64121764
113Status epilepticus (HP:0002133)1.63733875
114Postaxial foot polydactyly (HP:0001830)1.63110430
115Cortical dysplasia (HP:0002539)1.62386914
116Fair hair (HP:0002286)1.61932702
117Annular pancreas (HP:0001734)1.61861482
118Volvulus (HP:0002580)1.61777775
119Widely spaced teeth (HP:0000687)1.61724930
120Febrile seizures (HP:0002373)1.60451900
121Congenital stationary night blindness (HP:0007642)1.60322656
122Anophthalmia (HP:0000528)1.60154750
123Macroorchidism (HP:0000053)1.60112980
124Postaxial hand polydactyly (HP:0001162)1.59811161
125Sclerocornea (HP:0000647)1.59539989
126Anencephaly (HP:0002323)1.59357667
127Dysdiadochokinesis (HP:0002075)1.58771010
128Hypoplastic ischia (HP:0003175)1.58647706
129Obstructive sleep apnea (HP:0002870)1.58119931
130Tented upper lip vermilion (HP:0010804)1.58101724
131Short foot (HP:0001773)1.58072657
132Preaxial hand polydactyly (HP:0001177)1.58036110
133Action tremor (HP:0002345)1.57911797
134Deep palmar crease (HP:0006191)1.57527288
135Ventricular fibrillation (HP:0001663)1.57461062
136Abnormality of lateral ventricle (HP:0030047)1.57370850
137Aplasia/Hypoplasia of the patella (HP:0006498)1.56468905
138Severe muscular hypotonia (HP:0006829)1.56366371
139Truncal ataxia (HP:0002078)1.55935903
140Oligodactyly (hands) (HP:0001180)1.52652683
141Absence seizures (HP:0002121)1.51451824
142Slender long bone (HP:0003100)1.51305849
143Thyroid carcinoma (HP:0002890)1.51266107
144Abnormal glucose tolerance (HP:0001952)1.50417540
145Impulsivity (HP:0100710)1.48811829
146Breast aplasia (HP:0100783)1.47044002
147Hypoplasia of the maxilla (HP:0000327)1.46959722
148Dysmetric saccades (HP:0000641)1.46718245
149Narrow palate (HP:0000189)1.46409841
150Complete atrioventricular canal defect (HP:0001674)1.46272844
151Atrioventricular block (HP:0001678)1.44329680
152Lower limb asymmetry (HP:0100559)1.42676190
153Submucous cleft hard palate (HP:0000176)1.42342518
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.41688225
155Protruding tongue (HP:0010808)1.41620766
156Glucose intolerance (HP:0000833)1.40893486
157Epileptic encephalopathy (HP:0200134)1.40629626
158Abnormality of the corticospinal tract (HP:0002492)1.40605221
159Glioma (HP:0009733)1.40225089
160Male infertility (HP:0003251)1.39137367
161Sandal gap (HP:0001852)1.38875280
162Broad-based gait (HP:0002136)1.38472430
163Soft skin (HP:0000977)1.38390718
164Cafe-au-lait spot (HP:0000957)1.37494145
165CNS hypomyelination (HP:0003429)1.37054335
166Neuroectodermal neoplasm (HP:0030061)1.36146628
167Neuroepithelial neoplasm (HP:0030063)1.36146628
168Nervous tissue neoplasm (HP:0030060)1.36146628
169Transitional cell carcinoma of the bladder (HP:0006740)1.35388448
170Capillary hemangiomas (HP:0005306)1.35376935
171Short nail (HP:0001799)1.34383420
172Breast hypoplasia (HP:0003187)1.34286138
173Vertebral arch anomaly (HP:0008438)1.33790676
174Narrow nasal bridge (HP:0000446)1.33297813
175Restlessness (HP:0000711)1.33147979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT33.79829310
2LATS23.73814377
3LATS13.17150829
4PRKD32.89858639
5MAP3K92.55926977
6TNIK2.46348708
7STK382.23179225
8STK38L2.22391550
9PAK62.21747441
10MAP3K42.08089015
11NTRK32.05173521
12STK32.01235652
13PLK31.92853275
14PNCK1.92524208
15BMPR1B1.92232907
16NEK21.80915551
17KSR21.73479648
18PINK11.68109597
19BUB11.66377076
20PLK21.66127033
21BRSK21.60497542
22KSR11.59916006
23MARK11.54896389
24ADRBK21.54839012
25EPHA31.54004095
26BCR1.50769054
27CDC71.45792013
28PRPF4B1.42510249
29RIPK11.39386873
30PHKG21.38875480
31PHKG11.38875480
32EPHA41.31553657
33TAOK11.30545439
34BRSK11.28283142
35TYRO31.26521183
36MINK11.23357330
37NUAK11.22221426
38RAF11.17822391
39TRIM281.17649599
40PDGFRA1.17002898
41MAPK131.13090746
42SGK21.10070213
43FRK1.09868330
44DDR21.07585021
45ALK1.07130046
46DYRK21.05867794
47PDGFRB1.05052234
48MAP3K21.04462590
49NTRK21.03514438
50CCNB11.03369158
51PKN11.02155997
52WNK31.01356334
53CDK120.95211968
54CAMKK10.94964241
55UHMK10.94848367
56SGK30.94335993
57CASK0.92940432
58WEE10.92803572
59WNK40.92376916
60CSNK1G20.92076810
61SGK2230.90355423
62SGK4940.90355423
63BRAF0.88489958
64ARAF0.87042156
65CHEK20.86931636
66PRKCH0.86663141
67GRK10.84853621
68MAP2K70.84221680
69MAPK100.81971720
70CSNK1A1L0.81167781
71TRIB30.81057675
72CDK80.80337158
73PLK40.79884845
74CAMKK20.79477374
75CAMK2A0.78682179
76SIK20.78182467
77BRD40.77239510
78MKNK20.76727501
79NTRK10.75962292
80FGFR20.75013609
81PLK10.74604840
82PAK30.73774448
83CDK50.73221516
84STK110.71933851
85CAMK40.71014763
86DMPK0.70904335
87CAMK2B0.70688066
88PRKAA10.70037160
89FER0.68780694
90NEK10.67118030
91MAP4K20.66277711
92CSNK1G30.65943657
93CHEK10.65802686
94CAMK10.65453152
95MAP2K40.62845031
96SGK10.62629401
97NEK60.61535467
98DAPK20.61513258
99CAMK1D0.61133414
100ACVR1B0.60012292
101CSNK1G10.59411036
102CDK20.58513321
103PIK3CA0.58324751
104OBSCN0.57624803
105PRKD20.57409353
106PRKCE0.57283077
107CSNK1D0.56908290
108ERBB40.56584171
109TTK0.54424229
110CDK30.53883334
111WNK10.52822199
112MTOR0.52548239
113PDK20.51949587
114PRKCZ0.51534857
115CDK10.51530269
116CDK90.51257240
117CAMK1G0.49266469
118PAK20.48466557
119PDK40.48192790
120PDK30.48192790
121ATM0.48011063
122STK240.47381119
123EEF2K0.47327952
124EPHB20.46232772
125ERBB20.46083956
126RPS6KA30.45924471
127SRPK10.45339830
128CAMK2D0.44691577
129RPS6KB10.44405877
130GSK3B0.43556322
131ERBB30.42224981
132CSNK1E0.41751035
133STK390.41062363
134MAPK80.40606844
135DYRK1A0.38939565
136ZAK0.38813790
137MAPKAPK50.38793702
138PRKCG0.38389560
139TSSK60.37700460
140OXSR10.36416009
141PRKDC0.35919608
142CAMK2G0.35247813

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.51767136
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.54199488
3Long-term potentiation_Homo sapiens_hsa047201.86242631
4Nicotine addiction_Homo sapiens_hsa050331.86056809
5Synaptic vesicle cycle_Homo sapiens_hsa047211.73008554
6Oocyte meiosis_Homo sapiens_hsa041141.68588315
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.66621655
8Amphetamine addiction_Homo sapiens_hsa050311.64121030
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62587072
10Olfactory transduction_Homo sapiens_hsa047401.58164445
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.57142885
12Circadian entrainment_Homo sapiens_hsa047131.56814769
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55802623
14Glutamatergic synapse_Homo sapiens_hsa047241.53520525
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49286591
16GABAergic synapse_Homo sapiens_hsa047271.49030410
17Insulin secretion_Homo sapiens_hsa049111.48783510
18Selenocompound metabolism_Homo sapiens_hsa004501.47953155
19Dopaminergic synapse_Homo sapiens_hsa047281.47413726
20Morphine addiction_Homo sapiens_hsa050321.40365772
21mTOR signaling pathway_Homo sapiens_hsa041501.38697249
22Butanoate metabolism_Homo sapiens_hsa006501.35619339
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34774167
24Glioma_Homo sapiens_hsa052141.33046595
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31531619
26Cholinergic synapse_Homo sapiens_hsa047251.31372999
27Cell cycle_Homo sapiens_hsa041101.29901946
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27773008
29Long-term depression_Homo sapiens_hsa047301.27571395
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27394092
31Renal cell carcinoma_Homo sapiens_hsa052111.26980723
32Nitrogen metabolism_Homo sapiens_hsa009101.26834192
33Estrogen signaling pathway_Homo sapiens_hsa049151.25068804
34Circadian rhythm_Homo sapiens_hsa047101.23717228
35Endometrial cancer_Homo sapiens_hsa052131.22488713
36ErbB signaling pathway_Homo sapiens_hsa040121.21716174
37GnRH signaling pathway_Homo sapiens_hsa049121.20732636
38Lysine degradation_Homo sapiens_hsa003101.19373222
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19008099
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17624064
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17141412
42Ether lipid metabolism_Homo sapiens_hsa005651.14251216
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.13291989
44Cocaine addiction_Homo sapiens_hsa050301.12139619
45mRNA surveillance pathway_Homo sapiens_hsa030151.11270282
46Type II diabetes mellitus_Homo sapiens_hsa049301.10906237
47RNA transport_Homo sapiens_hsa030131.08742728
48Oxytocin signaling pathway_Homo sapiens_hsa049211.06914276
49Serotonergic synapse_Homo sapiens_hsa047261.06856770
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06396105
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04059032
52Fanconi anemia pathway_Homo sapiens_hsa034601.02519198
53Salivary secretion_Homo sapiens_hsa049701.01498476
54Dorso-ventral axis formation_Homo sapiens_hsa043201.01122142
55Gap junction_Homo sapiens_hsa045401.00868321
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.00700151
57Linoleic acid metabolism_Homo sapiens_hsa005910.99685782
58Renin secretion_Homo sapiens_hsa049240.98500297
59Taste transduction_Homo sapiens_hsa047420.96998878
60RNA polymerase_Homo sapiens_hsa030200.95708739
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95514713
62Basal cell carcinoma_Homo sapiens_hsa052170.95004723
63Colorectal cancer_Homo sapiens_hsa052100.94888227
64Hippo signaling pathway_Homo sapiens_hsa043900.94578362
65Gastric acid secretion_Homo sapiens_hsa049710.92636281
66MicroRNAs in cancer_Homo sapiens_hsa052060.90763724
67Melanogenesis_Homo sapiens_hsa049160.90314006
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.89913754
69Ovarian steroidogenesis_Homo sapiens_hsa049130.89871019
70Non-small cell lung cancer_Homo sapiens_hsa052230.87809920
71Choline metabolism in cancer_Homo sapiens_hsa052310.87462088
72p53 signaling pathway_Homo sapiens_hsa041150.86033766
73Inositol phosphate metabolism_Homo sapiens_hsa005620.85854921
74Pancreatic cancer_Homo sapiens_hsa052120.83626446
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.82851054
76MAPK signaling pathway_Homo sapiens_hsa040100.82764595
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82205109
78cAMP signaling pathway_Homo sapiens_hsa040240.81913627
79Axon guidance_Homo sapiens_hsa043600.80899767
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80826512
81ABC transporters_Homo sapiens_hsa020100.80308200
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79281195
83FoxO signaling pathway_Homo sapiens_hsa040680.79243679
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.77117135
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.76788193
86Chronic myeloid leukemia_Homo sapiens_hsa052200.76095601
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76007566
88Prostate cancer_Homo sapiens_hsa052150.75020851
89Basal transcription factors_Homo sapiens_hsa030220.74761639
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.74353906
91Phototransduction_Homo sapiens_hsa047440.71053002
92Melanoma_Homo sapiens_hsa052180.70763037
93Proteoglycans in cancer_Homo sapiens_hsa052050.70750466
94Steroid biosynthesis_Homo sapiens_hsa001000.70722987
95Dilated cardiomyopathy_Homo sapiens_hsa054140.69317454
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68909700
97Hedgehog signaling pathway_Homo sapiens_hsa043400.68494427
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68299879
99Wnt signaling pathway_Homo sapiens_hsa043100.67558689
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.67433804
101Ras signaling pathway_Homo sapiens_hsa040140.67308524
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66785390
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66753199
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65854075
105Regulation of autophagy_Homo sapiens_hsa041400.65178249
106Focal adhesion_Homo sapiens_hsa045100.64810924
107Glucagon signaling pathway_Homo sapiens_hsa049220.64344324
108Tight junction_Homo sapiens_hsa045300.63237154
109Calcium signaling pathway_Homo sapiens_hsa040200.60635783
110Fatty acid biosynthesis_Homo sapiens_hsa000610.59796825
111VEGF signaling pathway_Homo sapiens_hsa043700.59462330
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58972407
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57423754
114Endocytosis_Homo sapiens_hsa041440.57421210
115Rap1 signaling pathway_Homo sapiens_hsa040150.57162810
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57119975
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56456893
118Propanoate metabolism_Homo sapiens_hsa006400.56159363
119Adherens junction_Homo sapiens_hsa045200.55983342
120Collecting duct acid secretion_Homo sapiens_hsa049660.55885107
121beta-Alanine metabolism_Homo sapiens_hsa004100.55454526
122Prolactin signaling pathway_Homo sapiens_hsa049170.55180083
123Insulin signaling pathway_Homo sapiens_hsa049100.53911710
124AMPK signaling pathway_Homo sapiens_hsa041520.52913923
125Thyroid hormone synthesis_Homo sapiens_hsa049180.52572602
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52472743
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52012974
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.51685314
129Alcoholism_Homo sapiens_hsa050340.51148253
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49713202
131TGF-beta signaling pathway_Homo sapiens_hsa043500.47941614

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