RBP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cellular retinol-binding protein expressed highly in kidney and liver. Down-regulation of the encoded protein in hepatocellular carcinoma was associated with large tumor size and poor patient survival rates. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)8.68617125
2regulation of fibrinolysis (GO:0051917)8.23339322
3negative regulation of fibrinolysis (GO:0051918)8.16414848
4drug catabolic process (GO:0042737)8.13690224
5epoxygenase P450 pathway (GO:0019373)7.56599857
6glyoxylate metabolic process (GO:0046487)7.39631929
7L-phenylalanine catabolic process (GO:0006559)7.32450240
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.32450240
9omega-hydroxylase P450 pathway (GO:0097267)6.84213725
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77755661
11L-phenylalanine metabolic process (GO:0006558)6.77755661
12regulation of protein activation cascade (GO:2000257)6.74750340
13complement activation, alternative pathway (GO:0006957)6.55617499
14urea metabolic process (GO:0019627)6.53672894
15fibrinolysis (GO:0042730)6.39505297
16regulation of complement activation (GO:0030449)6.38419291
17negative regulation of sterol transport (GO:0032372)6.24105535
18negative regulation of cholesterol transport (GO:0032375)6.24105535
19protein carboxylation (GO:0018214)6.17217099
20peptidyl-glutamic acid carboxylation (GO:0017187)6.17217099
21ethanol oxidation (GO:0006069)6.16694672
22nitrogen cycle metabolic process (GO:0071941)5.96290923
23cellular glucuronidation (GO:0052695)5.82848768
24urea cycle (GO:0000050)5.65233809
25drug metabolic process (GO:0017144)5.61085469
26uronic acid metabolic process (GO:0006063)5.55725860
27glucuronate metabolic process (GO:0019585)5.55725860
28blood coagulation, intrinsic pathway (GO:0007597)5.54974235
29triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.38664647
30regulation of triglyceride catabolic process (GO:0010896)5.34172230
31phospholipid efflux (GO:0033700)5.31580427
32regulation of plasminogen activation (GO:0010755)5.29843550
33aromatic amino acid family catabolic process (GO:0009074)5.26484851
34phenylpropanoid metabolic process (GO:0009698)5.12038789
35oxidative demethylation (GO:0070989)5.11208621
36bile acid biosynthetic process (GO:0006699)5.00788517
37serine family amino acid catabolic process (GO:0009071)4.99094663
38ethanol metabolic process (GO:0006067)4.89914149
39high-density lipoprotein particle remodeling (GO:0034375)4.88320978
40negative regulation of blood coagulation (GO:0030195)4.82537373
41negative regulation of hemostasis (GO:1900047)4.82537373
42protein activation cascade (GO:0072376)4.81739600
43glycine metabolic process (GO:0006544)4.79300642
44protein-lipid complex remodeling (GO:0034368)4.78244750
45macromolecular complex remodeling (GO:0034367)4.78244750
46plasma lipoprotein particle remodeling (GO:0034369)4.78244750
47bile acid metabolic process (GO:0008206)4.77832639
48complement activation, classical pathway (GO:0006958)4.72364474
49acylglycerol homeostasis (GO:0055090)4.66652257
50triglyceride homeostasis (GO:0070328)4.66652257
51S-adenosylmethionine metabolic process (GO:0046500)4.61995718
52regulation of cholesterol esterification (GO:0010872)4.58353507
53cholesterol efflux (GO:0033344)4.57634208
54complement activation (GO:0006956)4.56474269
55amino-acid betaine metabolic process (GO:0006577)4.55875421
56bile acid and bile salt transport (GO:0015721)4.51321891
57very-low-density lipoprotein particle assembly (GO:0034379)4.48515100
58positive regulation of triglyceride lipase activity (GO:0061365)4.44158245
59positive regulation of lipoprotein lipase activity (GO:0051006)4.44158245
60negative regulation of coagulation (GO:0050819)4.36762660
61reverse cholesterol transport (GO:0043691)4.27990022
62alkaloid metabolic process (GO:0009820)4.26719452
63negative regulation of wound healing (GO:0061045)4.25093557
64response to mercury ion (GO:0046689)4.24810180
65positive regulation of blood coagulation (GO:0030194)4.23267657
66positive regulation of hemostasis (GO:1900048)4.23267657
67negative regulation of lipase activity (GO:0060192)4.22406349
68acute-phase response (GO:0006953)4.18936225
69regulation of humoral immune response (GO:0002920)4.16871963
70fat-soluble vitamin biosynthetic process (GO:0042362)4.14763383
71tyrosine metabolic process (GO:0006570)4.07637238
72intestinal cholesterol absorption (GO:0030299)4.05930123
73negative regulation of protein activation cascade (GO:2000258)4.05356654
74negative regulation of fatty acid biosynthetic process (GO:0045717)3.93129799
75positive regulation of coagulation (GO:0050820)3.87355677
76imidazole-containing compound metabolic process (GO:0052803)3.86101999
77plasma lipoprotein particle assembly (GO:0034377)3.81775686
78plasma lipoprotein particle clearance (GO:0034381)3.74352796
79plasma lipoprotein particle organization (GO:0071827)3.73189286
80arginine metabolic process (GO:0006525)3.70485716
81serine family amino acid metabolic process (GO:0009069)3.68174581
82flavonoid metabolic process (GO:0009812)3.62497419
83hormone catabolic process (GO:0042447)3.57293776
84glutamate metabolic process (GO:0006536)3.57157710
85regulation of lipoprotein particle clearance (GO:0010984)3.56191732
86fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.52299334
87protein-lipid complex subunit organization (GO:0071825)3.52171948
88alpha-amino acid catabolic process (GO:1901606)3.50609587
89disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.44160786
90killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.44160786
91indole-containing compound catabolic process (GO:0042436)3.43404505
92indolalkylamine catabolic process (GO:0046218)3.43404505
93tryptophan catabolic process (GO:0006569)3.43404505
94negative regulation of complement activation (GO:0045916)3.43335517
95protein-lipid complex assembly (GO:0065005)3.42289855
96negative regulation of lipid transport (GO:0032369)3.40443497
97positive regulation of lipid catabolic process (GO:0050996)3.39141747
98polyketide metabolic process (GO:0030638)3.38126753
99doxorubicin metabolic process (GO:0044598)3.38126753
100daunorubicin metabolic process (GO:0044597)3.38126753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.42066889
2PPARA_22158963_ChIP-Seq_LIVER_Mouse5.55114485
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.51867627
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.09790103
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.64370784
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.40279881
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.26804200
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.74091918
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.53054898
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.26457012
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.17194956
12FOXA2_19822575_ChIP-Seq_HepG2_Human2.13825923
13* HNF4A_19822575_ChIP-Seq_HepG2_Human2.10110813
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05862221
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1153111
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93845247
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87366492
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74409135
19LXR_22292898_ChIP-Seq_THP-1_Human1.53858221
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47127145
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.41794358
22RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40909784
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37163108
24CDX2_20551321_ChIP-Seq_CACO-2_Human1.30258117
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29959302
26SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15864476
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.14481019
28GATA6_25053715_ChIP-Seq_YYC3_Human1.13190378
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10553280
30RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09946733
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08946760
32CLOCK_20551151_ChIP-Seq_293T_Human1.07589460
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05143497
34SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03999128
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.01139101
36AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01120851
37GATA4_25053715_ChIP-Seq_YYC3_Human0.98754939
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98275865
39BP1_19119308_ChIP-ChIP_Hs578T_Human0.98274793
40BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98172483
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97169859
42* ELK3_25401928_ChIP-Seq_HUVEC_Human0.96136260
43TRIM28_21343339_ChIP-Seq_HEK293_Human0.95553695
44CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95329362
45GATA1_19941826_ChIP-Seq_K562_Human0.94503504
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.93148225
47GATA1_19941827_ChIP-Seq_MEL_Mouse0.92567890
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88846750
49ESR2_21235772_ChIP-Seq_MCF-7_Human0.85941484
50ELF1_20517297_ChIP-Seq_JURKAT_Human0.85407636
51GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84409644
52Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.82732390
53BCOR_27268052_Chip-Seq_Bcells_Human0.82146087
54SMC4_20622854_ChIP-Seq_HELA_Human0.81093756
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80342827
56FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.79001857
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78266813
58RACK7_27058665_Chip-Seq_MCF-7_Human0.78060878
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77945049
60SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.77941702
61VDR_21846776_ChIP-Seq_THP-1_Human0.75952835
62HTT_18923047_ChIP-ChIP_STHdh_Human0.74744836
63SPI1_20517297_ChIP-Seq_HL60_Human0.73307318
64GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73191598
65KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.72753218
66E2F1_20622854_ChIP-Seq_HELA_Human0.72739060
67CEBPB_22108803_ChIP-Seq_LS180_Human0.72656328
68IRF8_27001747_Chip-Seq_BMDM_Mouse0.72639367
69TCF7_22412390_ChIP-Seq_EML_Mouse0.72569992
70BCL6_27268052_Chip-Seq_Bcells_Human0.72496165
71RAC3_21632823_ChIP-Seq_H3396_Human0.72279202
72SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71663033
73SA1_27219007_Chip-Seq_Bcells_Human0.71660510
74FOXA1_25552417_ChIP-Seq_VCAP_Human0.71375751
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.71326527
76NCOR1_26117541_ChIP-Seq_K562_Human0.70901485
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.70704301
78VDR_24763502_ChIP-Seq_THP-1_Human0.69879840
79BRD4_27068464_Chip-Seq_AML-cells_Mouse0.69714764
80GATA2_19941826_ChIP-Seq_K562_Human0.69627013
81GATA2_21666600_ChIP-Seq_HMVEC_Human0.69128148
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68866413
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.68498394
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.68410437
85BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.68232193
86CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.67170824
87ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66785458
88P68_20966046_ChIP-Seq_HELA_Human0.66305123
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.66285318
90MAF_26560356_Chip-Seq_TH1_Human0.66130093
91CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.65845120
92PHF8_20622854_ChIP-Seq_HELA_Human0.65477639
93DNAJC2_21179169_ChIP-ChIP_NT2_Human0.65470664
94PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65232575
95P300_27268052_Chip-Seq_Bcells_Human0.64785159
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64168166
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.64126056
98SPI1_23127762_ChIP-Seq_K562_Human0.63873205
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63642333
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.63160455

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.31600626
2MP0005360_urolithiasis6.22055263
3MP0005085_abnormal_gallbladder_physiolo5.63750983
4MP0005365_abnormal_bile_salt5.52354983
5MP0003195_calcinosis4.91014253
6MP0008875_abnormal_xenobiotic_pharmacok4.67780431
7MP0002138_abnormal_hepatobiliary_system4.10346783
8MP0003252_abnormal_bile_duct3.83763091
9MP0001666_abnormal_nutrient_absorption3.41062494
10MP0009840_abnormal_foam_cell3.03914414
11MP0003868_abnormal_feces_composition2.90158421
12MP0010329_abnormal_lipoprotein_level2.85958819
13MP0005332_abnormal_amino_acid2.38293431
14MP0003191_abnormal_cellular_cholesterol2.34236300
15MP0009697_abnormal_copulation2.15410673
16MP0003806_abnormal_nucleotide_metabolis1.99090256
17MP0000609_abnormal_liver_physiology1.94142506
18MP0005451_abnormal_body_composition1.91156304
19MP0002876_abnormal_thyroid_physiology1.74877530
20MP0002118_abnormal_lipid_homeostasis1.72209760
21MP0004019_abnormal_vitamin_homeostasis1.48948250
22MP0001764_abnormal_homeostasis1.48079538
23MP0002132_abnormal_respiratory_system1.47876104
24MP0010368_abnormal_lymphatic_system1.40141086
25MP0009643_abnormal_urine_homeostasis1.34158808
26MP0003656_abnormal_erythrocyte_physiolo1.33686173
27MP0005319_abnormal_enzyme/_coenzyme1.21818989
28MP0005408_hypopigmentation1.17272937
29MP0000598_abnormal_liver_morphology1.07681987
30MP0005584_abnormal_enzyme/coenzyme_acti1.07603826
31MP0005464_abnormal_platelet_physiology1.05112455
32MP0008469_abnormal_protein_level0.99468616
33MP0001661_extended_life_span0.99096908
34MP0003436_decreased_susceptibility_to0.98658029
35MP0005058_abnormal_lysosome_morphology0.96196526
36MP0005636_abnormal_mineral_homeostasis0.93735490
37MP0009642_abnormal_blood_homeostasis0.92356090
38MP0002971_abnormal_brown_adipose0.90153937
39MP0005670_abnormal_white_adipose0.90032361
40MP0003303_peritoneal_inflammation0.88616887
41MP0009763_increased_sensitivity_to0.87269914
42MP0005376_homeostasis/metabolism_phenot0.81435374
43MP0001915_intracranial_hemorrhage0.79731339
44MP0003300_gastrointestinal_ulcer0.79672698
45MP0009785_altered_susceptibility_to0.78256395
46MP0003879_abnormal_hair_cell0.75855318
47MP0003186_abnormal_redox_activity0.74460317
48MP0009764_decreased_sensitivity_to0.74437673
49MP0000604_amyloidosis0.71035642
50MP0000685_abnormal_immune_system0.70226540
51MP0002168_other_aberrant_phenotype0.67211482
52MP0004043_abnormal_pH_regulation0.65845773
53MP0005535_abnormal_body_temperature0.65764876
54MP0010155_abnormal_intestine_physiology0.64504801
55MP0005395_other_phenotype0.63490959
56MP0001851_eye_inflammation0.63239961
57MP0002136_abnormal_kidney_physiology0.63147412
58MP0005023_abnormal_wound_healing0.61592964
59MP0005025_abnormal_response_to0.61575035
60MP0002078_abnormal_glucose_homeostasis0.60964132
61MP0001756_abnormal_urination0.60722137
62MP0005164_abnormal_response_to0.59563470
63MP0008874_decreased_physiological_sensi0.58891311
64MP0009053_abnormal_anal_canal0.58793489
65MP0004883_abnormal_blood_vessel0.57965676
66MP0000249_abnormal_blood_vessel0.57501140
67MP0005334_abnormal_fat_pad0.57012708
68MP0003172_abnormal_lysosome_physiology0.55675399
69MP0002249_abnormal_larynx_morphology0.55419107
70MP0002419_abnormal_innate_immunity0.54601221
71MP0001845_abnormal_inflammatory_respons0.53395288
72MP0003638_abnormal_response/metabolism_0.52986598
73MP0009115_abnormal_fat_cell0.51804245
74MP0003690_abnormal_glial_cell0.50697835
75MP0005166_decreased_susceptibility_to0.48587323
76MP0004782_abnormal_surfactant_physiolog0.48304212
77MP0003705_abnormal_hypodermis_morpholog0.47354138
78MP0003075_altered_response_to0.46171363
79MP0006036_abnormal_mitochondrial_physio0.45428359
80MP0005266_abnormal_metabolism0.45192694
81MP0009333_abnormal_splenocyte_physiolog0.44154169
82MP0005220_abnormal_exocrine_pancreas0.41929327
83MP0002282_abnormal_trachea_morphology0.41458206
84MP0005448_abnormal_energy_balance0.40111563
85MP0008872_abnormal_physiological_respon0.40011877
86MP0000858_altered_metastatic_potential0.39458382
87MP0002970_abnormal_white_adipose0.39285155
88MP0004264_abnormal_extraembryonic_tissu0.38911083
89MP0001533_abnormal_skeleton_physiology0.38639392
90MP0001800_abnormal_humoral_immune0.37036104
91MP0005397_hematopoietic_system_phenotyp0.36927949
92MP0001545_abnormal_hematopoietic_system0.36927949
93MP0005666_abnormal_adipose_tissue0.35390442
94MP0005409_darkened_coat_color0.33849800
95MP0008260_abnormal_autophagy0.33777591
96MP0009765_abnormal_xenobiotic_induced0.33028447
97MP0005647_abnormal_sex_gland0.31811971
98MP0003953_abnormal_hormone_level0.31614447
99MP0003183_abnormal_peptide_metabolism0.30704037
100MP0002166_altered_tumor_susceptibility0.30676406

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)9.54149231
2Abnormality of monocarboxylic acid metabolism (HP:0010996)9.38748555
3Prolonged partial thromboplastin time (HP:0003645)7.98977012
4Complement deficiency (HP:0004431)7.91700846
5Hypobetalipoproteinemia (HP:0003563)7.55178757
6Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44887431
7Abnormality of complement system (HP:0005339)6.70056179
8Systemic lupus erythematosus (HP:0002725)6.29849942
9Joint hemorrhage (HP:0005261)5.85019609
10Hyperlipoproteinemia (HP:0010980)5.51472270
11Conjugated hyperbilirubinemia (HP:0002908)5.17118633
12Xanthomatosis (HP:0000991)4.81854595
13Glomerulonephritis (HP:0000099)4.77878337
14Hypolipoproteinemia (HP:0010981)4.45340014
15Abnormality of the common coagulation pathway (HP:0010990)4.41685814
16Abnormality of pyrimidine metabolism (HP:0004353)4.31258264
17Intrahepatic cholestasis (HP:0001406)4.06294833
18Recurrent gram-negative bacterial infections (HP:0005420)3.98127620
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.91278241
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.81130715
21Hemorrhage of the eye (HP:0011885)3.66516962
22Nephritis (HP:0000123)3.66480937
23Spontaneous abortion (HP:0005268)3.51055579
24Abnormality of the intrinsic pathway (HP:0010989)3.47154619
25Fat malabsorption (HP:0002630)3.31721244
26Rickets (HP:0002748)3.12283303
27Hyperammonemia (HP:0001987)3.03373524
28Gingival bleeding (HP:0000225)3.03273016
29Hypercholesterolemia (HP:0003124)2.96741906
30Hypoalphalipoproteinemia (HP:0003233)2.94573747
31Vascular calcification (HP:0004934)2.84705234
32Mitral stenosis (HP:0001718)2.84456978
33Generalized aminoaciduria (HP:0002909)2.83046722
34Steatorrhea (HP:0002570)2.77515587
35Purpura (HP:0000979)2.76837936
36Delayed CNS myelination (HP:0002188)2.72111829
37Menorrhagia (HP:0000132)2.69707323
38Abnormality of methionine metabolism (HP:0010901)2.69457707
39Hyperglycinemia (HP:0002154)2.64150619
40Abnormality of nucleobase metabolism (HP:0010932)2.64019511
41Thrombophlebitis (HP:0004418)2.60594265
42Pulmonary embolism (HP:0002204)2.52820008
43Cardiovascular calcification (HP:0011915)2.52516373
44Abnormality of glycine metabolism (HP:0010895)2.44770925
45Abnormality of serine family amino acid metabolism (HP:0010894)2.44770925
46Osteomalacia (HP:0002749)2.44496932
47Cholecystitis (HP:0001082)2.34561345
48Abnormal gallbladder physiology (HP:0012438)2.34561345
49Epidermoid cyst (HP:0200040)2.33576438
50Hyperbilirubinemia (HP:0002904)2.29319981
51Hyperglycinuria (HP:0003108)2.26988970
52Abnormality of aspartate family amino acid metabolism (HP:0010899)2.26036298
53Alkalosis (HP:0001948)2.22373315
54Impaired platelet aggregation (HP:0003540)2.19372523
55Abnormal platelet function (HP:0011869)2.19372523
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.17406982
57Hepatocellular carcinoma (HP:0001402)2.13975860
58Abnormality of urine glucose concentration (HP:0011016)2.10141247
59Glycosuria (HP:0003076)2.10141247
60Hyperphosphaturia (HP:0003109)2.10001212
61Myocardial infarction (HP:0001658)2.04088120
62Abnormality of vitamin metabolism (HP:0100508)2.03073807
63Poikilocytosis (HP:0004447)2.02271377
64Epistaxis (HP:0000421)2.00514160
65Abnormality of iron homeostasis (HP:0011031)1.98794894
66Abnormality of serum amino acid levels (HP:0003112)1.97190548
67Metabolic acidosis (HP:0001942)1.96641568
68Elevated alkaline phosphatase (HP:0003155)1.95417572
69Abnormality of the Achilles tendon (HP:0005109)1.94537400
70Increased serum ferritin (HP:0003281)1.93919868
71Abnormality of proline metabolism (HP:0010907)1.93599332
72Hydroxyprolinuria (HP:0003080)1.93599332
73Reticulocytosis (HP:0001923)1.93383431
74Abnormal enzyme/coenzyme activity (HP:0012379)1.92746805
75Neonatal hypoglycemia (HP:0001998)1.91858583
76Hypophosphatemic rickets (HP:0004912)1.90605603
77Gout (HP:0001997)1.90487914
78Increased mean platelet volume (HP:0011877)1.89543471
79Abnormality of purine metabolism (HP:0004352)1.87368416
80Joint swelling (HP:0001386)1.86343579
81Polycythemia (HP:0001901)1.85470690
82Abnormality of alkaline phosphatase activity (HP:0004379)1.85395625
83Abnormal platelet volume (HP:0011876)1.84950148
84Cholelithiasis (HP:0001081)1.84821531
85Abnormal urine phosphate concentration (HP:0012599)1.81703728
86Gangrene (HP:0100758)1.81660098
87Hypochromic microcytic anemia (HP:0004840)1.81391596
88Reduced antithrombin III activity (HP:0001976)1.80455550
89Fair hair (HP:0002286)1.77249790
90Hypophosphatemia (HP:0002148)1.76248230
91Abnormality of transition element cation homeostasis (HP:0011030)1.73826960
92Abnormal gallbladder morphology (HP:0012437)1.73535895
93Arthropathy (HP:0003040)1.73393742
94Hypochromic anemia (HP:0001931)1.71298886
95Potter facies (HP:0002009)1.70636523
96Facial shape deformation (HP:0011334)1.70636523
97Acanthocytosis (HP:0001927)1.70190011
98Ketosis (HP:0001946)1.66741794
99Urinary glycosaminoglycan excretion (HP:0003541)1.64538034
100Mucopolysacchariduria (HP:0008155)1.64538034

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN16.53232732
2FGFR44.12134281
3TYK22.92041884
4TRIB32.91264577
5PRPF4B2.70641827
6CDK122.35821414
7FGFR32.27932967
8PIK3CG2.21893946
9RIPK12.01244679
10SIK11.94971007
11MST1R1.89089517
12MAP4K11.69391484
13ICK1.68499731
14TBK11.64508131
15MAPK111.61272047
16EPHB11.49947547
17RIPK41.49702499
18MAP3K141.38484685
19MAP2K31.37950690
20MAP3K11.36486289
21JAK11.34799635
22ZAP701.32497294
23TESK21.27840668
24TNK21.26447568
25PRKAA21.25824456
26MAP3K31.24216371
27EPHA31.22260847
28WNK31.18487811
29PDPK11.17105690
30MAP3K21.16930970
31KSR21.16896420
32BLK1.13929891
33IRAK31.10270200
34JAK31.07460562
35PTK61.07361517
36NLK1.05876008
37EEF2K1.05135543
38MAP3K131.03708630
39PRKACG1.01941361
40CDC42BPA1.01540403
41MAP3K71.00745036
42SMG11.00410485
43JAK20.94837590
44GRK60.93771886
45NTRK30.91037622
46TGFBR20.88093231
47PDGFRA0.87254403
48RET0.87040320
49NEK90.85280005
50MAP3K60.82501849
51CSF1R0.81979127
52PDK10.81311513
53ACVR1B0.79623805
54PKN20.76680684
55PIK3CA0.76486646
56RAF10.75030534
57CDK60.74826806
58SGK30.72033577
59PDK20.71120148
60CDK40.70858002
61MAP3K100.70758571
62MTOR0.67642376
63ERBB20.63406586
64LATS10.63386624
65WNK40.61737956
66IKBKE0.59301863
67BMX0.55775971
68PRKAA10.55618671
69SGK20.54735188
70BTK0.53906080
71MAPK70.52525054
72IGF1R0.52195675
73OXSR10.50902359
74IRAK40.50809212
75MYLK0.49730736
76MAPK40.49371989
77IRAK10.48592747
78FES0.48184402
79PRKG20.47096641
80MAP2K20.46968024
81MAP2K60.46559446
82SGK2230.46412975
83SGK4940.46412975
84TAOK20.45973343
85LRRK20.45032525
86PRKD20.42030293
87CDK90.42020683
88MAP2K40.41340210
89LCK0.41247532
90HCK0.41149966
91MAPK120.39544092
92MAPKAPK30.38965999
93DYRK1B0.38826611
94PRKCZ0.38806131
95SIK20.38741647
96TRPM70.38512603
97MAP3K110.38354148
98BCKDK0.37865770
99MAPK30.37746516
100SYK0.37417607

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.56056308
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.03025149
3Complement and coagulation cascades_Homo sapiens_hsa046103.82532754
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.67418403
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.42360545
6Retinol metabolism_Homo sapiens_hsa008303.30255652
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.25384937
8Chemical carcinogenesis_Homo sapiens_hsa052042.79762436
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.79109488
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70418420
11Drug metabolism - other enzymes_Homo sapiens_hsa009832.66788389
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.66057318
13Arginine biosynthesis_Homo sapiens_hsa002202.65502372
14Phenylalanine metabolism_Homo sapiens_hsa003602.52962432
15Steroid hormone biosynthesis_Homo sapiens_hsa001402.48387993
16Fatty acid degradation_Homo sapiens_hsa000712.48059193
17Butanoate metabolism_Homo sapiens_hsa006502.16718716
18Tyrosine metabolism_Homo sapiens_hsa003502.16378172
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06132469
20Histidine metabolism_Homo sapiens_hsa003401.92744975
21Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.83585693
22Tryptophan metabolism_Homo sapiens_hsa003801.81557066
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.77061150
24Bile secretion_Homo sapiens_hsa049761.74504108
25Linoleic acid metabolism_Homo sapiens_hsa005911.62605746
26Starch and sucrose metabolism_Homo sapiens_hsa005001.58163122
27Staphylococcus aureus infection_Homo sapiens_hsa051501.53653239
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47806256
29PPAR signaling pathway_Homo sapiens_hsa033201.40226554
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31385615
31Peroxisome_Homo sapiens_hsa041461.21682068
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20730915
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.14013309
34beta-Alanine metabolism_Homo sapiens_hsa004101.12656358
35Fat digestion and absorption_Homo sapiens_hsa049751.11727223
36Arachidonic acid metabolism_Homo sapiens_hsa005901.04511589
37Biosynthesis of amino acids_Homo sapiens_hsa012301.04321483
38Arginine and proline metabolism_Homo sapiens_hsa003301.00014995
39Pyruvate metabolism_Homo sapiens_hsa006200.97793227
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95761582
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94952811
42Prion diseases_Homo sapiens_hsa050200.93995242
43Vitamin B6 metabolism_Homo sapiens_hsa007500.91844402
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89466822
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88415607
46Carbon metabolism_Homo sapiens_hsa012000.88293028
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81387062
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81114337
49Fatty acid metabolism_Homo sapiens_hsa012120.80680825
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80270362
51Propanoate metabolism_Homo sapiens_hsa006400.74348607
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.71116665
53Lysine degradation_Homo sapiens_hsa003100.68904160
54ABC transporters_Homo sapiens_hsa020100.68450456
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.66203117
56One carbon pool by folate_Homo sapiens_hsa006700.66102753
57Fructose and mannose metabolism_Homo sapiens_hsa000510.52231509
58Vitamin digestion and absorption_Homo sapiens_hsa049770.50233149
59Other glycan degradation_Homo sapiens_hsa005110.48754548
60Glycosaminoglycan degradation_Homo sapiens_hsa005310.45260247
61Pertussis_Homo sapiens_hsa051330.42265460
62Sulfur metabolism_Homo sapiens_hsa009200.41969976
63Sulfur relay system_Homo sapiens_hsa041220.39523003
64Glycerolipid metabolism_Homo sapiens_hsa005610.35987320
65Metabolic pathways_Homo sapiens_hsa011000.35324083
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35263348
67Insulin resistance_Homo sapiens_hsa049310.33352993
68Pentose phosphate pathway_Homo sapiens_hsa000300.30257075
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25944843
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20691087
71Renin-angiotensin system_Homo sapiens_hsa046140.20403303
72Galactose metabolism_Homo sapiens_hsa000520.17159255
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.14909210
74Glucagon signaling pathway_Homo sapiens_hsa049220.11561494
75Fatty acid elongation_Homo sapiens_hsa000620.09392058
76Steroid biosynthesis_Homo sapiens_hsa001000.09169315
77Glutathione metabolism_Homo sapiens_hsa004800.06838036
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.04698549
79Mineral absorption_Homo sapiens_hsa049780.04336157
80African trypanosomiasis_Homo sapiens_hsa051430.03613206
81Glycerophospholipid metabolism_Homo sapiens_hsa005640.02565620
82Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1890669
83Ether lipid metabolism_Homo sapiens_hsa00565-0.1842944
84Serotonergic synapse_Homo sapiens_hsa04726-0.1821848
85Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1780089
86B cell receptor signaling pathway_Homo sapiens_hsa04662-0.1758752
87Leishmaniasis_Homo sapiens_hsa05140-0.1747735
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.1738364
89NF-kappa B signaling pathway_Homo sapiens_hsa04064-0.1614482
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1566244
91Acute myeloid leukemia_Homo sapiens_hsa05221-0.1491600
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1438782
93Fatty acid biosynthesis_Homo sapiens_hsa00061-0.1299034
94Hepatitis C_Homo sapiens_hsa05160-0.1117522
95Insulin signaling pathway_Homo sapiens_hsa04910-0.0918642
96Sphingolipid metabolism_Homo sapiens_hsa00600-0.0902516
97Selenocompound metabolism_Homo sapiens_hsa00450-0.0618076
98AMPK signaling pathway_Homo sapiens_hsa04152-0.0425837
99Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.0296552
100Amoebiasis_Homo sapiens_hsa05146-0.0042311

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