RBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.63550753
2pyrimidine nucleobase catabolic process (GO:0006208)5.54573428
3diaphragm development (GO:0060539)5.38564396
4viral transcription (GO:0019083)5.29198264
5skeletal muscle organ development (GO:0060538)5.20564382
6translational termination (GO:0006415)4.96984889
7outer ear morphogenesis (GO:0042473)4.84953364
8behavioral response to nicotine (GO:0035095)4.73734489
9nucleobase catabolic process (GO:0046113)4.58211847
10ribosomal small subunit biogenesis (GO:0042274)4.39651117
11regulation of gonadotropin secretion (GO:0032276)4.22593640
12paraxial mesoderm development (GO:0048339)4.17928846
13translational elongation (GO:0006414)4.12713315
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.11364783
15pattern specification involved in kidney development (GO:0061004)4.09878430
16definitive hemopoiesis (GO:0060216)4.07256565
17glucocorticoid biosynthetic process (GO:0006704)4.00848329
18cotranslational protein targeting to membrane (GO:0006613)4.00068329
19protein targeting to ER (GO:0045047)3.98745503
20glomerulus development (GO:0032835)3.93452866
21somite development (GO:0061053)3.91494527
22retinal ganglion cell axon guidance (GO:0031290)3.90990220
23respiratory tube development (GO:0030323)3.87599479
24viral life cycle (GO:0019058)3.85661736
25nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.83192116
26mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.81873100
27metanephric mesenchyme development (GO:0072075)3.81719886
28establishment of protein localization to endoplasmic reticulum (GO:0072599)3.74352449
29mesenchyme morphogenesis (GO:0072132)3.71911233
30protein localization to endoplasmic reticulum (GO:0070972)3.69807037
31protein heterotrimerization (GO:0070208)3.68697424
32kidney mesenchyme development (GO:0072074)3.68646342
33establishment of tissue polarity (GO:0007164)3.65869309
34establishment of planar polarity (GO:0001736)3.65869309
35cellular protein complex disassembly (GO:0043624)3.65710394
36mesenchymal cell differentiation involved in kidney development (GO:0072161)3.65126455
37mesenchymal cell differentiation involved in renal system development (GO:2001012)3.65126455
38bone trabecula formation (GO:0060346)3.63643817
39G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.62246531
40axonal fasciculation (GO:0007413)3.60235597
41facial nerve structural organization (GO:0021612)3.59562083
42dendritic spine morphogenesis (GO:0060997)3.57900576
43extracellular fibril organization (GO:0043206)3.51194648
44negative regulation of axon guidance (GO:1902668)3.51073765
45estrogen biosynthetic process (GO:0006703)3.41703136
46lymph vessel development (GO:0001945)3.40331642
47auditory behavior (GO:0031223)3.39018668
48mesenchymal to epithelial transition (GO:0060231)3.38861929
49cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.38537645
50cell proliferation involved in metanephros development (GO:0072203)3.37716412
51limb bud formation (GO:0060174)3.37658269
52positive regulation of gastrulation (GO:2000543)3.37628836
53protein complex disassembly (GO:0043241)3.36254251
54ganglion development (GO:0061548)3.35911107
55platelet dense granule organization (GO:0060155)3.33401189
56endocardial cushion morphogenesis (GO:0003203)3.32713600
57mesonephros development (GO:0001823)3.32303938
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.30591881
59axon extension involved in axon guidance (GO:0048846)3.30591881
60maturation of SSU-rRNA (GO:0030490)3.26988404
61dopaminergic neuron differentiation (GO:0071542)3.24983873
62translational initiation (GO:0006413)3.24277292
63urogenital system development (GO:0001655)3.23208436
64presynaptic membrane organization (GO:0097090)3.22310660
65cochlea morphogenesis (GO:0090103)3.19114004
66neuron recognition (GO:0008038)3.18730577
67regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.17432187
68cellular response to gonadotropin stimulus (GO:0071371)3.16294058
69kidney morphogenesis (GO:0060993)3.14338576
70sequestering of actin monomers (GO:0042989)3.13018187
71negative regulation of chondrocyte differentiation (GO:0032331)3.11321793
72macromolecular complex disassembly (GO:0032984)3.08758374
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.08643031
74regulation of axon guidance (GO:1902667)3.06751674
75cell differentiation involved in metanephros development (GO:0072202)3.03746257
76presynaptic membrane assembly (GO:0097105)3.02341382
77glomerular basement membrane development (GO:0032836)3.01625911
78fibril organization (GO:0097435)3.00776919
79* vitamin A metabolic process (GO:0006776)3.00607242
80smooth muscle tissue development (GO:0048745)3.00082138
81epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.99054861
82regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97260134
83middle ear morphogenesis (GO:0042474)2.96240013
84negative regulation of axon extension involved in axon guidance (GO:0048843)2.96059890
85mesenchymal-epithelial cell signaling (GO:0060638)2.94741044
86negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.93614578
87cell proliferation involved in kidney development (GO:0072111)2.92861338
88regulation of mesenchymal cell apoptotic process (GO:2001053)2.92118715
89cardiac right ventricle morphogenesis (GO:0003215)2.90884245
90nonmotile primary cilium assembly (GO:0035058)2.89512857
91collagen fibril organization (GO:0030199)2.88735801
92peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.88585165
93dermatan sulfate biosynthetic process (GO:0030208)2.86312434
94synaptic transmission, cholinergic (GO:0007271)2.86081126
95glial cell proliferation (GO:0014009)2.85103711
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84915761
97branching involved in ureteric bud morphogenesis (GO:0001658)2.83853161
98cell migration in hindbrain (GO:0021535)2.83691068
99mesenchymal cell proliferation (GO:0010463)2.82374501
100proximal/distal pattern formation (GO:0009954)2.82153592
101short-term memory (GO:0007614)2.81119079
102arginine catabolic process (GO:0006527)2.77343549
103ureteric bud development (GO:0001657)2.75794086
104response to leptin (GO:0044321)2.74897909
105behavioral response to ethanol (GO:0048149)2.74796180
106mesenchymal cell development (GO:0014031)2.74269234
107postsynaptic membrane organization (GO:0001941)2.73745645
108lung vasculature development (GO:0060426)2.73132419
109mesonephric tubule development (GO:0072164)2.69959933
110neuromuscular synaptic transmission (GO:0007274)2.69517128
111retinal metabolic process (GO:0042574)2.69032043
112planar cell polarity pathway involved in neural tube closure (GO:0090179)2.68716854
113mesenchyme development (GO:0060485)2.68373962
114chondrocyte proliferation (GO:0035988)2.67960514
115regulation of axon extension involved in axon guidance (GO:0048841)2.67833737
116lung-associated mesenchyme development (GO:0060484)2.67113313
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.66234220
118regulation of non-canonical Wnt signaling pathway (GO:2000050)2.65608514
119spinal cord development (GO:0021510)2.65588805
120response to follicle-stimulating hormone (GO:0032354)2.65377283
121mechanosensory behavior (GO:0007638)2.65043932
122epithelial cilium movement (GO:0003351)2.64419222
123dermatan sulfate metabolic process (GO:0030205)2.64285757
124regulation of male gonad development (GO:2000018)2.63462482
125nuclear-transcribed mRNA catabolic process (GO:0000956)2.63228488
126regulation of heart morphogenesis (GO:2000826)2.62425496
127neural crest cell development (GO:0014032)2.62237538
128substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.62150431
129substrate-independent telencephalic tangential migration (GO:0021826)2.62150431
130heart valve morphogenesis (GO:0003179)2.61916982
131basement membrane organization (GO:0071711)2.61364621
132embryonic digestive tract development (GO:0048566)2.61284551
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60315901
134mesonephric epithelium development (GO:0072163)2.59713080
135embryonic skeletal system morphogenesis (GO:0048704)2.59201852
136positive regulation of male gonad development (GO:2000020)2.59051582
137sequestering of extracellular ligand from receptor (GO:0035581)2.59039024
138protein targeting to membrane (GO:0006612)2.58744183
139cranial nerve structural organization (GO:0021604)2.57890117
140diterpenoid biosynthetic process (GO:0016102)2.56987404
141negative chemotaxis (GO:0050919)2.56716542
142neurofilament cytoskeleton organization (GO:0060052)2.56540765
143regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.55697293
144androgen biosynthetic process (GO:0006702)2.55118439
145blood vessel maturation (GO:0001955)2.54694941
146epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.53996602
147transmission of nerve impulse (GO:0019226)2.53814955
148innervation (GO:0060384)2.53686981
149regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.51865664
150segment specification (GO:0007379)2.51347510
151hindbrain development (GO:0030902)2.50163530
152spinal cord association neuron differentiation (GO:0021527)2.50141264
153metanephros development (GO:0001656)2.50134369
154sex determination (GO:0007530)2.49619717
155neuron cell-cell adhesion (GO:0007158)2.49240423
156cellular response to leptin stimulus (GO:0044320)2.49106340
157metanephric epithelium development (GO:0072207)2.48187111
158intraciliary transport (GO:0042073)2.47023739
159protein localization to synapse (GO:0035418)2.45312191
160calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.44706535
161glucocorticoid metabolic process (GO:0008211)2.44696678
162synapse assembly (GO:0007416)2.44517378
163pancreas development (GO:0031016)2.44275611
164negative regulation of macrophage differentiation (GO:0045650)2.43894593
165response to auditory stimulus (GO:0010996)2.41164175
166protein localization to cilium (GO:0061512)2.40212861
167central nervous system projection neuron axonogenesis (GO:0021952)2.39871961
168sympathetic nervous system development (GO:0048485)2.39842685
169neuronal ion channel clustering (GO:0045161)2.37357410
170toxin metabolic process (GO:0009404)2.37320519
171midbrain development (GO:0030901)2.35972007
172ATP synthesis coupled proton transport (GO:0015986)2.34848750
173energy coupled proton transport, down electrochemical gradient (GO:0015985)2.34848750
174peristalsis (GO:0030432)2.31525358
175cochlea development (GO:0090102)2.31389905
176neuron fate determination (GO:0048664)2.31043857
177negative regulation of axon extension (GO:0030517)2.30259280
178cranial nerve development (GO:0021545)2.30115652
179positive regulation of synapse assembly (GO:0051965)2.29370470
180endocrine pancreas development (GO:0031018)2.27014503
181cell differentiation in spinal cord (GO:0021515)2.26858427
182establishment of protein localization to mitochondrial membrane (GO:0090151)2.24773339
183neurotransmitter-gated ion channel clustering (GO:0072578)2.23554902
184axon extension (GO:0048675)2.23424068
185mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.21651337
186appendage development (GO:0048736)2.21553981
187limb development (GO:0060173)2.21553981
188head development (GO:0060322)2.20918735
189smoothened signaling pathway (GO:0007224)2.20475967
190response to gonadotropin (GO:0034698)2.19955297
191central nervous system neuron axonogenesis (GO:0021955)2.14768794

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.89016558
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.87267297
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.67404679
4TRIM28_21343339_ChIP-Seq_HEK293_Human4.20428498
5RARG_19884340_ChIP-ChIP_MEFs_Mouse4.17887543
6EZH2_22144423_ChIP-Seq_EOC_Human4.11035054
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.73337451
8NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.29503983
9TP63_19390658_ChIP-ChIP_HaCaT_Human3.27724169
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23202830
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.89957346
12PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.74825605
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71978517
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.61825265
15GBX2_23144817_ChIP-Seq_PC3_Human2.53836843
16KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.53229789
17TP53_20018659_ChIP-ChIP_R1E_Mouse2.51902691
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.50870733
19POU5F1_16153702_ChIP-ChIP_HESCs_Human2.43638215
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.33219018
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.32339912
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.29592219
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.19138295
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18517040
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16677030
26CLOCK_20551151_ChIP-Seq_293T_Human2.14358820
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12923029
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.11611449
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08424428
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.07842126
31RNF2_27304074_Chip-Seq_NSC_Mouse2.04126703
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95988510
33SOX2_18555785_ChIP-Seq_MESCs_Mouse1.93238223
34XRN2_22483619_ChIP-Seq_HELA_Human1.88530754
35REST_21632747_ChIP-Seq_MESCs_Mouse1.87502499
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86158618
37ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84641125
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82110874
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78483674
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77815051
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.75890945
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.75348303
43CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74302545
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73504902
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70380930
46ZNF274_21170338_ChIP-Seq_K562_Hela1.68689225
47* NANOG_16153702_ChIP-ChIP_HESCs_Human1.67405832
48* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.62673478
49CBX2_27304074_Chip-Seq_ESCs_Mouse1.60107786
50VDR_22108803_ChIP-Seq_LS180_Human1.59871780
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.56929938
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.56365234
53* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55527390
54TAF15_26573619_Chip-Seq_HEK293_Human1.54382808
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52676073
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52492710
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52221752
58P300_19829295_ChIP-Seq_ESCs_Human1.51612994
59E2F7_22180533_ChIP-Seq_HELA_Human1.50747858
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49812668
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.49369490
62SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48125912
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.47659463
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47044587
65MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46045593
66SCL_19346495_ChIP-Seq_HPC-7_Human1.45500718
67KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44427507
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44427507
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44427507
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43999757
71FUS_26573619_Chip-Seq_HEK293_Human1.42118373
72CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41790202
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.37992265
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.37578729
75* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36537244
76SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.36172079
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.35680757
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35554477
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34605346
80CDX2_20551321_ChIP-Seq_CACO-2_Human1.34434881
81SMAD4_21799915_ChIP-Seq_A2780_Human1.33072371
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.32801332
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32172470
84IGF1R_20145208_ChIP-Seq_DFB_Human1.31986223
85* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31491788
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31431660
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31431660
88EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31257777
89RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31257777
90DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29552041
91* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29091926
92MYC_19030024_ChIP-ChIP_MESCs_Mouse1.28377523
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27430297
94EWS_26573619_Chip-Seq_HEK293_Human1.26274615
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25424813
96TTF2_22483619_ChIP-Seq_HELA_Human1.25169121
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.24477453
98NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24301848
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23668936
100E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21804182
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20700614
102* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.20252429
103STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20176274
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18626228
105AR_25329375_ChIP-Seq_VCAP_Human1.16826351
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.15890013
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15382674
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15240116
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15112579
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14705417
111* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13255304
112SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13145329
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11973887
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11501194
115OCT4_18692474_ChIP-Seq_MEFs_Mouse1.11261660
116MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10764826
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09371574
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08964186
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07260423
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06911287
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06590972
122STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05272239
123* IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05143818
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02929293
125NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02495717
126ELK3_25401928_ChIP-Seq_HUVEC_Human1.02375162
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01544336
128NANOG_18555785_Chip-Seq_ESCs_Mouse1.01454138
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00849561
130FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00210680
131NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.99414934
132PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99327098
133MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98879824
134RUNX2_22187159_ChIP-Seq_PCA_Human0.98356729
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97779964
136CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96866324
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96450578
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96334820
139* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95872541
140P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95310998
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.94425353
142EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94381693
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.93734902
144FLI1_27457419_Chip-Seq_LIVER_Mouse0.92681908
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92223674
146BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92191654
147BCAT_22108803_ChIP-Seq_LS180_Human0.92100892
148TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92071452
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.92026976
150* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91633617
151EP300_21415370_ChIP-Seq_HL-1_Mouse0.91212991
152TP53_18474530_ChIP-ChIP_U2OS_Human0.90924117
153CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90333743
154PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89732928
155SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89241997
156NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88987670
157CREB1_15753290_ChIP-ChIP_HEK293T_Human0.88318260
158HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88297632
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87889527
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.87875187
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87548293
162TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87427743
163SA1_22415368_ChIP-Seq_MEFs_Mouse0.87411609
164TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87256611
165WT1_19549856_ChIP-ChIP_CCG9911_Human0.87157857
166SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87066433
167BRD4_25478319_ChIP-Seq_HGPS_Human0.85468708
168WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84617201
169MYC_18940864_ChIP-ChIP_HL60_Human0.83217953
170RNF2_27304074_Chip-Seq_ESCs_Mouse0.82609152
171SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81724896

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology4.83869599
2MP0003283_abnormal_digestive_organ4.23454378
3MP0008438_abnormal_cutaneous_collagen4.20805445
4MP0010030_abnormal_orbit_morphology4.01824639
5MP0002249_abnormal_larynx_morphology3.62845890
6MP0010368_abnormal_lymphatic_system3.48987127
7MP0005275_abnormal_skin_tensile3.47741647
8MP0002822_catalepsy3.00859619
9MP0006054_spinal_hemorrhage2.80116404
10MP0002282_abnormal_trachea_morphology2.68482050
11MP0003942_abnormal_urinary_system2.67567363
12MP0000049_abnormal_middle_ear2.64521515
13* MP0003011_delayed_dark_adaptation2.64506049
14MP0005423_abnormal_somatic_nervous2.62739837
15MP0003880_abnormal_central_pattern2.47767041
16MP0000778_abnormal_nervous_system2.42466774
17MP0000537_abnormal_urethra_morphology2.36151893
18MP0003279_aneurysm2.27725330
19MP0001529_abnormal_vocalization2.23382493
20MP0009379_abnormal_foot_pigmentation2.19243797
21MP0004272_abnormal_basement_membrane2.19160348
22MP0001879_abnormal_lymphatic_vessel2.17437026
23MP0000534_abnormal_ureter_morphology2.11799788
24MP0005508_abnormal_skeleton_morphology2.10345218
25MP0002909_abnormal_adrenal_gland2.09108839
26MP0002638_abnormal_pupillary_reflex2.07066838
27MP0006276_abnormal_autonomic_nervous2.06191004
28MP0003315_abnormal_perineum_morphology2.05717082
29MP0009250_abnormal_appendicular_skeleto2.03200964
30MP0009053_abnormal_anal_canal2.00207291
31MP0005248_abnormal_Harderian_gland1.98726629
32MP0002938_white_spotting1.94351431
33MP0002932_abnormal_joint_morphology1.94303989
34MP0003385_abnormal_body_wall1.94231410
35MP0002751_abnormal_autonomic_nervous1.87997572
36MP0001958_emphysema1.87253279
37MP0006072_abnormal_retinal_apoptosis1.81431705
38MP0003115_abnormal_respiratory_system1.72907219
39MP0001984_abnormal_olfaction1.71607216
40MP0003787_abnormal_imprinting1.68735193
41MP0002184_abnormal_innervation1.66083987
42MP0000566_synostosis1.66002300
43* MP0005253_abnormal_eye_physiology1.59536284
44MP0005499_abnormal_olfactory_system1.59518265
45MP0005394_taste/olfaction_phenotype1.59518265
46MP0008789_abnormal_olfactory_epithelium1.56231894
47MP0000516_abnormal_urinary_system1.55327670
48MP0005367_renal/urinary_system_phenotyp1.55327670
49MP0002653_abnormal_ependyma_morphology1.52801814
50MP0000631_abnormal_neuroendocrine_gland1.50926186
51MP0003890_abnormal_embryonic-extraembry1.50176749
52MP0010386_abnormal_urinary_bladder1.49470052
53MP0000955_abnormal_spinal_cord1.48434174
54MP0002233_abnormal_nose_morphology1.46958650
55MP0003195_calcinosis1.45151942
56MP0002557_abnormal_social/conspecific_i1.42225211
57MP0000767_abnormal_smooth_muscle1.37644246
58MP0002108_abnormal_muscle_morphology1.37287231
59MP0004270_analgesia1.36094955
60MP0002734_abnormal_mechanical_nocicepti1.36040419
61MP0003941_abnormal_skin_development1.35345251
62MP0001270_distended_abdomen1.35005606
63* MP0005551_abnormal_eye_electrophysiolog1.32502810
64MP0005257_abnormal_intraocular_pressure1.29703531
65MP0008995_early_reproductive_senescence1.29429741
66MP0002736_abnormal_nociception_after1.28223945
67MP0008004_abnormal_stomach_pH1.27758893
68MP0002272_abnormal_nervous_system1.27602885
69MP0003567_abnormal_fetal_cardiomyocyte1.26270641
70MP0005623_abnormal_meninges_morphology1.25193798
71MP0003938_abnormal_ear_development1.24735461
72MP0009745_abnormal_behavioral_response1.23638470
73* MP0002752_abnormal_somatic_nervous1.23635390
74MP0000462_abnormal_digestive_system1.23001295
75MP0000163_abnormal_cartilage_morphology1.22696525
76MP0002572_abnormal_emotion/affect_behav1.22360874
77MP0003122_maternal_imprinting1.21822248
78MP0003635_abnormal_synaptic_transmissio1.20472266
79MP0003935_abnormal_craniofacial_develop1.20130054
80MP0000428_abnormal_craniofacial_morphol1.18845894
81MP0001293_anophthalmia1.17787348
82MP0002102_abnormal_ear_morphology1.17551283
83MP0002063_abnormal_learning/memory/cond1.17069437
84MP0005386_behavior/neurological_phenoty1.16753300
85MP0004924_abnormal_behavior1.16753300
86MP0000639_abnormal_adrenal_gland1.15949910
87* MP0002882_abnormal_neuron_morphology1.15639592
88MP0000678_abnormal_parathyroid_gland1.15590544
89MP0001286_abnormal_eye_development1.15418244
90MP0005187_abnormal_penis_morphology1.13281788
91MP0001486_abnormal_startle_reflex1.13206108
92MP0002060_abnormal_skin_morphology1.13195790
93MP0003705_abnormal_hypodermis_morpholog1.11324291
94MP0004142_abnormal_muscle_tone1.11142766
95MP0000762_abnormal_tongue_morphology1.08577430
96MP0003937_abnormal_limbs/digits/tail_de1.08456658
97MP0003136_yellow_coat_color1.06406894
98MP0000026_abnormal_inner_ear1.05087757
99MP0005377_hearing/vestibular/ear_phenot1.04951373
100MP0003878_abnormal_ear_physiology1.04951373
101* MP0005195_abnormal_posterior_eye1.04604604
102MP0008877_abnormal_DNA_methylation1.04501053
103MP0004885_abnormal_endolymph1.03923986
104MP0002116_abnormal_craniofacial_bone1.03772079
105MP0003755_abnormal_palate_morphology1.03771908
106MP0001968_abnormal_touch/_nociception1.03712409
107MP0002928_abnormal_bile_duct1.03269496
108MP0002092_abnormal_eye_morphology1.02431513
109MP0006292_abnormal_olfactory_placode1.01721770
110MP0002089_abnormal_postnatal_growth/wei1.01550748
111MP0005023_abnormal_wound_healing1.00796020
112MP0001485_abnormal_pinna_reflex1.00644582
113MP0004742_abnormal_vestibular_system0.99333510
114MP0009046_muscle_twitch0.98634661
115MP0001970_abnormal_pain_threshold0.98240127
116MP0001502_abnormal_circadian_rhythm0.98174143
117MP0002735_abnormal_chemical_nociception0.97743632
118MP0003861_abnormal_nervous_system0.97716798
119MP0003943_abnormal_hepatobiliary_system0.97308903
120MP0004883_abnormal_blood_vessel0.97008240
121MP0002177_abnormal_outer_ear0.96890020
122MP0005084_abnormal_gallbladder_morpholo0.96169598
123MP0002009_preneoplasia0.95548623
124MP0002114_abnormal_axial_skeleton0.95274963
125MP0002254_reproductive_system_inflammat0.94951802
126MP0005646_abnormal_pituitary_gland0.94042225
127MP0001905_abnormal_dopamine_level0.93898175
128MP0002064_seizures0.93030063
129MP0004859_abnormal_synaptic_plasticity0.92572211
130MP0002128_abnormal_blood_circulation0.91282319
131MP0008007_abnormal_cellular_replicative0.91101038
132MP0002152_abnormal_brain_morphology0.90632543
133MP0009384_cardiac_valve_regurgitation0.90600992
134MP0002067_abnormal_sensory_capabilities0.89896698
135MP0001915_intracranial_hemorrhage0.88680905
136MP0001188_hyperpigmentation0.88577084
137MP0002109_abnormal_limb_morphology0.88495811
138MP0004811_abnormal_neuron_physiology0.87971099
139MP0002090_abnormal_vision0.87647425
140MP0003123_paternal_imprinting0.86294021
141MP0008875_abnormal_xenobiotic_pharmacok0.86008299
142MP0000681_abnormal_thyroid_gland0.85606606
143MP0001440_abnormal_grooming_behavior0.85362293
144MP0002132_abnormal_respiratory_system0.84679515
145MP0003119_abnormal_digestive_system0.84250094
146MP0005197_abnormal_uvea_morphology0.83381993
147MP0005390_skeleton_phenotype0.82916630
148MP0000432_abnormal_head_morphology0.82785462
149MP0001944_abnormal_pancreas_morphology0.82692886
150MP0004145_abnormal_muscle_electrophysio0.82563263
151MP0000467_abnormal_esophagus_morphology0.79864018
152MP0001175_abnormal_lung_morphology0.79821280
153MP0002113_abnormal_skeleton_development0.79746232
154MP0002127_abnormal_cardiovascular_syste0.76887047
155MP0002115_abnormal_skeleton_extremities0.76320973
156MP0001614_abnormal_blood_vessel0.75967745
157MP0002111_abnormal_tail_morphology0.75239895
158MP0004133_heterotaxia0.74106893
159MP0002697_abnormal_eye_size0.73273301
160MP0000613_abnormal_salivary_gland0.71279159
161MP0000538_abnormal_urinary_bladder0.70208945
162MP0002234_abnormal_pharynx_morphology0.69911015
163MP0005193_abnormal_anterior_eye0.69120754
164MP0005171_absent_coat_pigmentation0.68966989
165MP0004808_abnormal_hematopoietic_stem0.67322937
166MP0002135_abnormal_kidney_morphology0.66094967
167* MP0005391_vision/eye_phenotype0.65788398
168MP0008932_abnormal_embryonic_tissue0.65029429
169MP0003121_genomic_imprinting0.64147966
170MP0001243_abnormal_dermal_layer0.62571282
171MP0004134_abnormal_chest_morphology0.62530896

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.48855725
2Aplasia/Hypoplasia of the sacrum (HP:0008517)4.45315326
3Broad metatarsal (HP:0001783)4.02726793
4Reticulocytopenia (HP:0001896)3.38908575
5Renal duplication (HP:0000075)3.32403828
6Bicornuate uterus (HP:0000813)3.30450630
7Pulmonary artery stenosis (HP:0004415)3.23695787
8Germ cell neoplasia (HP:0100728)3.09232222
9Biconcave vertebral bodies (HP:0004586)3.07674446
10Mesangial abnormality (HP:0001966)3.05023704
11Short tibia (HP:0005736)3.01820029
12Shallow orbits (HP:0000586)3.01020559
13Abnormal sex determination (HP:0012244)2.95065490
14Sex reversal (HP:0012245)2.95065490
15Abnormality of dentin (HP:0010299)2.93616178
16Limb dystonia (HP:0002451)2.91562214
17Morphological abnormality of the middle ear (HP:0008609)2.91387918
18Aplasia/Hypoplasia of the tibia (HP:0005772)2.83238239
19Bladder diverticulum (HP:0000015)2.82086437
20Soft skin (HP:0000977)2.80388386
21Oligodactyly (hands) (HP:0001180)2.73230606
22True hermaphroditism (HP:0010459)2.72294498
23Aortic dissection (HP:0002647)2.70436848
24Genital tract atresia (HP:0001827)2.69992031
25Abnormal lung lobation (HP:0002101)2.65499283
26Vaginal atresia (HP:0000148)2.65206574
27Medial flaring of the eyebrow (HP:0010747)2.65161217
28Neonatal short-limb short stature (HP:0008921)2.58833407
29Abnormal pancreas size (HP:0012094)2.58622864
30Premature rupture of membranes (HP:0001788)2.56994477
31Gait imbalance (HP:0002141)2.56702927
32Male pseudohermaphroditism (HP:0000037)2.55567841
33Short 4th metacarpal (HP:0010044)2.54030324
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.54030324
35Pancreatic fibrosis (HP:0100732)2.51204680
36Atrophic scars (HP:0001075)2.51178509
37Polyphagia (HP:0002591)2.46553872
38Renovascular hypertension (HP:0100817)2.44704024
39Ankle contracture (HP:0006466)2.43663321
40Agitation (HP:0000713)2.42045947
41Oligodactyly (HP:0012165)2.42020617
42Annular pancreas (HP:0001734)2.38745433
43Congenital stationary night blindness (HP:0007642)2.38713840
44Flat cornea (HP:0007720)2.37230629
45Stenosis of the external auditory canal (HP:0000402)2.35410857
46Cupped ear (HP:0000378)2.35083292
47Congenital primary aphakia (HP:0007707)2.32000570
48Hepatoblastoma (HP:0002884)2.31675552
49Hypoplastic left heart (HP:0004383)2.31235327
50Asymmetry of the thorax (HP:0001555)2.30839563
51Gonadotropin excess (HP:0000837)2.28981377
52Pancreatic cysts (HP:0001737)2.28302427
53Abnormality of the axillary hair (HP:0100134)2.27683551
54Abnormality of secondary sexual hair (HP:0009888)2.27683551
55Nephronophthisis (HP:0000090)2.26742148
56Molar tooth sign on MRI (HP:0002419)2.26717609
57Abnormality of midbrain morphology (HP:0002418)2.26717609
58Hypothermia (HP:0002045)2.24842501
59Labial hypoplasia (HP:0000066)2.23788213
60Blue sclerae (HP:0000592)2.23647707
61Abnormality of the parietal bone (HP:0002696)2.22136319
62Colon cancer (HP:0003003)2.21947514
63Hyperacusis (HP:0010780)2.21348831
64Syringomyelia (HP:0003396)2.20182974
65Spinal cord lesions (HP:0100561)2.20182974
66Abnormality of cells of the erythroid lineage (HP:0012130)2.19832004
67Increased corneal curvature (HP:0100692)2.19772154
68Keratoconus (HP:0000563)2.19772154
69Nephrogenic diabetes insipidus (HP:0009806)2.17983668
70Choroideremia (HP:0001139)2.16949647
71Vaginal fistula (HP:0004320)2.15607862
72Calcaneovalgus deformity (HP:0001848)2.14673487
73Embryonal neoplasm (HP:0002898)2.13723896
74Gonadal dysgenesis (HP:0000133)2.12700255
75Redundant skin (HP:0001582)2.12312245
76Septate vagina (HP:0001153)2.12242885
77Absent hair (HP:0002298)2.10984492
78Abnormality of the aortic arch (HP:0012303)2.09869593
79Occipital encephalocele (HP:0002085)2.08903053
80Abnormality of the 4th metacarpal (HP:0010012)2.08182457
81Aplasia/hypoplasia of the uterus (HP:0008684)2.07343726
82Ulnar claw (HP:0001178)2.03004385
83Aortic aneurysm (HP:0004942)2.02937172
84Anomalous pulmonary venous return (HP:0010772)2.02585412
85Bony spicule pigmentary retinopathy (HP:0007737)2.00339812
86Mitral valve prolapse (HP:0001634)2.00061233
87Rectovaginal fistula (HP:0000143)1.98250539
88Rectal fistula (HP:0100590)1.98250539
89Congenital malformation of the right heart (HP:0011723)1.97233637
90Double outlet right ventricle (HP:0001719)1.97233637
91Myokymia (HP:0002411)1.95853423
92Hypoplastic female external genitalia (HP:0012815)1.95492368
93Wide anterior fontanel (HP:0000260)1.95392974
94Abnormality of the renal medulla (HP:0100957)1.95383659
95Anophthalmia (HP:0000528)1.94866414
96Abnormal number of erythroid precursors (HP:0012131)1.94576515
97Vertebral compression fractures (HP:0002953)1.93602134
98Pallor (HP:0000980)1.92907420
99Hypoplasia of the uterus (HP:0000013)1.90961298
100Intestinal atresia (HP:0011100)1.90041132
101Onycholysis (HP:0001806)1.89212113
102Arnold-Chiari malformation (HP:0002308)1.88386684
103Macrocytic anemia (HP:0001972)1.86113861
104Acute necrotizing encephalopathy (HP:0006965)1.85940786
105Deformed tarsal bones (HP:0008119)1.85615970
106Sprengel anomaly (HP:0000912)1.84730599
107Medulloblastoma (HP:0002885)1.84357372
108Wormian bones (HP:0002645)1.84274994
109Diastasis recti (HP:0001540)1.84246436
110Delayed cranial suture closure (HP:0000270)1.83922237
111Back pain (HP:0003418)1.83781629
112Retinal dysplasia (HP:0007973)1.83462795
113Embryonal renal neoplasm (HP:0011794)1.82785610
114Natal tooth (HP:0000695)1.81361847
115Chronic hepatic failure (HP:0100626)1.81242280
116Decreased testicular size (HP:0008734)1.79047207
117Camptodactyly of toe (HP:0001836)1.78813061
118Hypoplasia of the ulna (HP:0003022)1.77918961
119Bronchomalacia (HP:0002780)1.76696240
120Fragile skin (HP:0001030)1.76563411
121Selective tooth agenesis (HP:0001592)1.75201513
122Postaxial hand polydactyly (HP:0001162)1.74180507
123Cystic liver disease (HP:0006706)1.74097016
124Abnormality of the pulmonary veins (HP:0011718)1.74020870
125Chorioretinal atrophy (HP:0000533)1.73704782
126Partial duplication of the phalanx of hand (HP:0009999)1.73320199
127Rib fusion (HP:0000902)1.73270195
128Type II lissencephaly (HP:0007260)1.72996864
129Sclerocornea (HP:0000647)1.72461827
130Bowel diverticulosis (HP:0005222)1.72368524
131Myelomeningocele (HP:0002475)1.71933011
132Esophageal neoplasm (HP:0100751)1.71780828
133Neoplasm of head and neck (HP:0012288)1.71780828
134Adrenal hypoplasia (HP:0000835)1.71587530
135Decreased skull ossification (HP:0004331)1.71083568
136Renal dysplasia (HP:0000110)1.71054996
137Abnormality of the anterior chamber (HP:0000593)1.70517688
138Wide cranial sutures (HP:0010537)1.70194671
139Poor suck (HP:0002033)1.70184332
140Abnormality of the intervertebral disk (HP:0005108)1.69868791
141Abnormal hemoglobin (HP:0011902)1.69778155
142Amblyopia (HP:0000646)1.69616700
143Hypoplastic heart (HP:0001961)1.69529547
144Scrotal hypoplasia (HP:0000046)1.69283788
145Renal hypoplasia (HP:0000089)1.69075721
146Bilateral microphthalmos (HP:0007633)1.68371967
147Septo-optic dysplasia (HP:0100842)1.67987230
148Elfin facies (HP:0004428)1.66414307
149Abnormal delivery (HP:0001787)1.66163767
150Pachygyria (HP:0001302)1.65698287
151Midline defect of the nose (HP:0004122)1.65677077
152Increased hepatocellular lipid droplets (HP:0006565)1.65660500
153Coronal craniosynostosis (HP:0004440)1.65654774
154Rectal prolapse (HP:0002035)1.65195990
155Cutaneous finger syndactyly (HP:0010554)1.64964948
156Abnormality of the labia minora (HP:0012880)1.64901955
157Lissencephaly (HP:0001339)1.64841056
158Partial agenesis of the corpus callosum (HP:0001338)1.64782730
159Aortic valve stenosis (HP:0001650)1.64677821
160Congenital, generalized hypertrichosis (HP:0004540)1.64472116
161Vitreoretinal degeneration (HP:0000655)1.63257760
162Anencephaly (HP:0002323)1.63170482
163Abnormality of the middle phalanges of the toes (HP:0010183)1.63061475
164Lymphangioma (HP:0100764)1.62828538
165Nephroblastoma (Wilms tumor) (HP:0002667)1.62633498
166Exotropia (HP:0000577)1.62061981
167Concave nail (HP:0001598)1.61853942
168Micropenis (HP:0000054)1.61853078
169Woolly hair (HP:0002224)1.61758471
170Tarsal synostosis (HP:0008368)1.61665115
171Mitochondrial inheritance (HP:0001427)1.61651443
172Vascular tortuosity (HP:0004948)1.61604052
173Coarctation of aorta (HP:0001680)1.60865118
174Poor coordination (HP:0002370)1.60384723
175Progressive macrocephaly (HP:0004481)1.59365722
176Aplasia/Hypoplasia of the ulna (HP:0006495)1.58316382
177Vertebral clefting (HP:0008428)1.57855262
178Bifid tongue (HP:0010297)1.57167896
179Renal Fanconi syndrome (HP:0001994)1.56752288
180Short femoral neck (HP:0100864)1.56383498
181Chorioretinal coloboma (HP:0000567)1.56084446
182Specific learning disability (HP:0001328)1.55971522
183Pendular nystagmus (HP:0012043)1.53405595
184Abnormal respiratory motile cilium morphology (HP:0005938)1.53044193
185Abnormal respiratory epithelium morphology (HP:0012253)1.53044193
186Abnormality of the labia (HP:0000058)1.52708307
187Aplasia/Hypoplasia of the lens (HP:0008063)1.52123675
188Aplasia/Hypoplasia of the hallux (HP:0008362)1.51088552

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB23.99976624
2CASK3.93079489
3MARK13.91754816
4TIE13.75605829
5TGFBR13.45097663
6MKNK13.12821561
7TGFBR23.07491100
8PNCK2.88272580
9TNIK2.55764912
10WNK32.40299215
11LMTK22.31038036
12SIK12.27170594
13PAK42.25128368
14MAP3K42.24956644
15MYLK2.20077809
16NME22.19855660
17DDR22.15993730
18ACVR1B2.08990685
19LATS12.06741416
20NTRK32.02132741
21FER1.98017411
22INSRR1.94358405
23LRRK21.84006995
24PINK11.78114603
25BCKDK1.77872483
26MKNK21.77610023
27CDK81.75118794
28DYRK31.71368131
29MAPK151.70683807
30TLK11.68741547
31MAP4K21.67570599
32KDR1.60371169
33ADRBK21.58685773
34DYRK21.55771338
35FRK1.55143682
36ERBB31.51523760
37BCR1.48585620
38PRKCG1.47746692
39NEK91.44192128
40RPS6KB21.44102221
41PDGFRA1.43827216
42CDK71.43798265
43SRPK11.42219167
44PTK61.40781856
45NTRK21.40448011
46PAK31.36641996
47FGFR21.36288409
48EPHA31.35310795
49TRIM281.33047354
50ILK1.32617596
51PKN21.29524163
52MINK11.23659435
53EPHA41.22848259
54STK161.22262693
55PIK3CA1.14274815
56DYRK1B1.14115796
57TNK21.13660455
58STK241.13450117
59CSNK1G21.10123421
60LATS21.09914051
61ERBB21.09637165
62ADRBK11.07409062
63TRIB31.06569537
64PHKG11.03380029
65PHKG21.03380029
66STK391.01185388
67FLT30.97393602
68MAPK130.93608072
69MATK0.92424136
70WNK40.90144530
71MAP3K60.90121765
72PRKCE0.89320679
73SGK2230.89239441
74SGK4940.89239441
75VRK20.89023597
76PAK20.88580122
77FGFR10.87946305
78CSNK1G10.87194720
79ERN10.86187353
80LIMK10.85819284
81CAMK1G0.85389197
82RPS6KA40.84142502
83IRAK10.81361130
84ROCK20.80842187
85CSNK1G30.80559205
86VRK10.78916185
87NUAK10.78212839
88CDK50.77965471
89PASK0.77937152
90DAPK20.77046667
91BUB10.73952558
92STK38L0.73041359
93CDK60.70821553
94STK110.70590520
95PTK20.69477125
96NME10.69137742
97MAP2K40.69054009
98ROCK10.67383775
99BTK0.67148053
100CSNK1A1L0.63845358
101AURKB0.63755098
102BMPR1B0.63636048
103NTRK10.63567003
104OXSR10.62987170
105TESK10.62618985
106EPHA20.62125824
107RPS6KA50.61491780
108MAPK40.60827261
109MAP3K120.60540339
110SGK20.60243186
111EEF2K0.60099752
112PIK3CG0.59644377
113PRKACA0.58203139
114CAMK2A0.57605780
115TAF10.56896026
116PLK20.56654044
117YES10.55956105
118ZAK0.54663810
119KIT0.54277459
120CHUK0.53759784
121KSR10.53673042
122PLK30.53350679
123CSNK2A10.52408024
124PRKCZ0.52325344
125MAP2K70.51116228
126WEE10.50456897
127TYRO30.50421576
128MAP2K20.50356630
129CAMK1D0.50014879
130MUSK0.49789225
131ABL20.49595800
132CDK180.46717851
133MAPK90.45331415
134CDK150.43754310
135CDK140.43436413
136DAPK30.42544698
137BRD40.41349183
138GRK10.41177630
139CSNK1A10.40972203
140CDK11A0.40438283
141CDK30.40189994
142STK30.40110490
143CSNK1E0.39695092
144CDK190.39490583
145UHMK10.38302589
146PRKAA10.38129073
147ATR0.36071855
148CAMK2B0.35373667
149RPS6KA20.34530411
150PIM20.33986807
151IGF1R0.31818091
152PAK10.31778576
153MAPKAPK30.31227064
154AKT20.29521246
155BMX0.29291894
156EPHB10.28672190
157CSNK2A20.28533458
158PRKD20.28194381
159MAPKAPK20.28090544
160MAP2K60.26707075
161PRKG20.25418996
162DYRK1A0.24669096

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.47496755
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.17985017
3Steroid biosynthesis_Homo sapiens_hsa001002.94530653
4Oxidative phosphorylation_Homo sapiens_hsa001902.86453883
5Phototransduction_Homo sapiens_hsa047442.61749799
6Basal cell carcinoma_Homo sapiens_hsa052172.56918926
7DNA replication_Homo sapiens_hsa030302.27703546
8ECM-receptor interaction_Homo sapiens_hsa045122.14668886
9Spliceosome_Homo sapiens_hsa030402.13634096
10Complement and coagulation cascades_Homo sapiens_hsa046102.10930462
11Nicotine addiction_Homo sapiens_hsa050332.04647223
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00722338
13Cardiac muscle contraction_Homo sapiens_hsa042602.00540612
14Mismatch repair_Homo sapiens_hsa034302.00334864
15Ovarian steroidogenesis_Homo sapiens_hsa049131.82623798
16Fatty acid degradation_Homo sapiens_hsa000711.78357687
17Hedgehog signaling pathway_Homo sapiens_hsa043401.76027633
18Chemical carcinogenesis_Homo sapiens_hsa052041.70699940
19Alzheimers disease_Homo sapiens_hsa050101.66862269
20Retinol metabolism_Homo sapiens_hsa008301.65865485
21Nucleotide excision repair_Homo sapiens_hsa034201.60608059
22Base excision repair_Homo sapiens_hsa034101.58684648
23TGF-beta signaling pathway_Homo sapiens_hsa043501.58387711
24Hippo signaling pathway_Homo sapiens_hsa043901.58128494
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55575086
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53911796
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48952664
28Cocaine addiction_Homo sapiens_hsa050301.46047731
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.43980890
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.43461996
31RNA polymerase_Homo sapiens_hsa030201.43230094
32Fat digestion and absorption_Homo sapiens_hsa049751.41403233
33Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.40774659
34GABAergic synapse_Homo sapiens_hsa047271.36907043
35Proteasome_Homo sapiens_hsa030501.36687113
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33267910
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.32730130
38Glutamatergic synapse_Homo sapiens_hsa047241.31458900
39Small cell lung cancer_Homo sapiens_hsa052221.26858342
40Pyrimidine metabolism_Homo sapiens_hsa002401.25932346
41Insulin secretion_Homo sapiens_hsa049111.25240420
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24229387
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.23188058
44Bladder cancer_Homo sapiens_hsa052191.22153197
45Dopaminergic synapse_Homo sapiens_hsa047281.20071140
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19912852
47Circadian entrainment_Homo sapiens_hsa047131.19766067
48Tyrosine metabolism_Homo sapiens_hsa003501.18447222
49Glutathione metabolism_Homo sapiens_hsa004801.17143846
50Linoleic acid metabolism_Homo sapiens_hsa005911.16834423
51Focal adhesion_Homo sapiens_hsa045101.14404958
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13228073
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12201777
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.10540445
55Collecting duct acid secretion_Homo sapiens_hsa049661.10301890
56Sulfur relay system_Homo sapiens_hsa041221.10253675
57Fatty acid metabolism_Homo sapiens_hsa012121.09618390
58Notch signaling pathway_Homo sapiens_hsa043301.09157082
59Protein digestion and absorption_Homo sapiens_hsa049741.07861909
60Serotonergic synapse_Homo sapiens_hsa047261.06716712
61Cell cycle_Homo sapiens_hsa041101.06480191
62Arachidonic acid metabolism_Homo sapiens_hsa005901.05846434
63Proteoglycans in cancer_Homo sapiens_hsa052051.04823587
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04636298
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04497090
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04328714
67Pancreatic secretion_Homo sapiens_hsa049721.02840306
68Morphine addiction_Homo sapiens_hsa050320.99512062
69Pathways in cancer_Homo sapiens_hsa052000.99214207
70Synaptic vesicle cycle_Homo sapiens_hsa047210.98752640
71Caffeine metabolism_Homo sapiens_hsa002320.97046207
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95206670
73PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94430028
74Bile secretion_Homo sapiens_hsa049760.94302610
75Thyroid cancer_Homo sapiens_hsa052160.92031067
76Fatty acid elongation_Homo sapiens_hsa000620.91907769
77Chronic myeloid leukemia_Homo sapiens_hsa052200.91229484
78Wnt signaling pathway_Homo sapiens_hsa043100.90446264
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89615958
80Malaria_Homo sapiens_hsa051440.88930878
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87835386
82Cholinergic synapse_Homo sapiens_hsa047250.86489277
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86484871
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86063284
85Amphetamine addiction_Homo sapiens_hsa050310.83933151
86Ether lipid metabolism_Homo sapiens_hsa005650.83856848
87Taste transduction_Homo sapiens_hsa047420.82114317
88Galactose metabolism_Homo sapiens_hsa000520.81675762
89Basal transcription factors_Homo sapiens_hsa030220.81356481
90Vitamin digestion and absorption_Homo sapiens_hsa049770.80663383
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79596329
92Propanoate metabolism_Homo sapiens_hsa006400.79478893
93PPAR signaling pathway_Homo sapiens_hsa033200.78653842
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78518838
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75944478
96MicroRNAs in cancer_Homo sapiens_hsa052060.75877421
97Histidine metabolism_Homo sapiens_hsa003400.75837307
98Tryptophan metabolism_Homo sapiens_hsa003800.75502955
99Melanogenesis_Homo sapiens_hsa049160.74675195
100Melanoma_Homo sapiens_hsa052180.74620847
101beta-Alanine metabolism_Homo sapiens_hsa004100.73767154
102HTLV-I infection_Homo sapiens_hsa051660.73525940
103Phenylalanine metabolism_Homo sapiens_hsa003600.73028628
104Parkinsons disease_Homo sapiens_hsa050120.72802406
105Adherens junction_Homo sapiens_hsa045200.70840750
106One carbon pool by folate_Homo sapiens_hsa006700.69557124
107Circadian rhythm_Homo sapiens_hsa047100.68013181
108Peroxisome_Homo sapiens_hsa041460.67926436
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66835413
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65407832
111Colorectal cancer_Homo sapiens_hsa052100.64500769
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.63380584
113Gap junction_Homo sapiens_hsa045400.63105066
114Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60412405
115Homologous recombination_Homo sapiens_hsa034400.60024242
116Long-term depression_Homo sapiens_hsa047300.58435322
117RNA degradation_Homo sapiens_hsa030180.57480937
118Vibrio cholerae infection_Homo sapiens_hsa051100.55127930
119Nitrogen metabolism_Homo sapiens_hsa009100.54777938
120N-Glycan biosynthesis_Homo sapiens_hsa005100.54160084
121Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53927922
122Amoebiasis_Homo sapiens_hsa051460.53375579
123Olfactory transduction_Homo sapiens_hsa047400.52337713
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52330234
125cAMP signaling pathway_Homo sapiens_hsa040240.52132228
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51594407
127Tight junction_Homo sapiens_hsa045300.51310048
128Biosynthesis of amino acids_Homo sapiens_hsa012300.50645387
129ABC transporters_Homo sapiens_hsa020100.49771377
130RNA transport_Homo sapiens_hsa030130.49309766
131Metabolic pathways_Homo sapiens_hsa011000.48996178
132Axon guidance_Homo sapiens_hsa043600.48802448
133Systemic lupus erythematosus_Homo sapiens_hsa053220.48798830
134Purine metabolism_Homo sapiens_hsa002300.48547001
135Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48218547
136Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47855316
137Dilated cardiomyopathy_Homo sapiens_hsa054140.46825101
138Gastric acid secretion_Homo sapiens_hsa049710.46227748
139Huntingtons disease_Homo sapiens_hsa050160.44994666
140Thyroid hormone synthesis_Homo sapiens_hsa049180.44502871
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44024005
142Pyruvate metabolism_Homo sapiens_hsa006200.43979310
143Butanoate metabolism_Homo sapiens_hsa006500.43856405
144Glycerolipid metabolism_Homo sapiens_hsa005610.43582738
145Selenocompound metabolism_Homo sapiens_hsa004500.42988693
146Lysine degradation_Homo sapiens_hsa003100.41816283
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41805754
148Protein export_Homo sapiens_hsa030600.41693493
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40932542
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40867779
151Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40545760
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.40384430

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