RBMXP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.89905484
2cytidine metabolic process (GO:0046087)5.48744009
3cytidine catabolic process (GO:0006216)5.48744009
4cytidine deamination (GO:0009972)5.48744009
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.03855615
6tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.49747430
7RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.49747430
8pyrimidine ribonucleoside catabolic process (GO:0046133)4.48515389
9behavioral response to nicotine (GO:0035095)4.03894315
10establishment of protein localization to mitochondrial membrane (GO:0090151)3.78642469
11regulation of cellular amino acid metabolic process (GO:0006521)3.74237703
12protein neddylation (GO:0045116)3.70909589
13negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.68928885
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.62941189
15DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61466370
16ATP synthesis coupled proton transport (GO:0015986)3.59052669
17energy coupled proton transport, down electrochemical gradient (GO:0015985)3.59052669
18aggressive behavior (GO:0002118)3.57374208
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54658997
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54658997
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54658997
22signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.49463355
23intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.49463355
24nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47008211
25exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44699669
26proteasome assembly (GO:0043248)3.43875510
27signal transduction involved in DNA integrity checkpoint (GO:0072401)3.37889436
28signal transduction involved in DNA damage checkpoint (GO:0072422)3.37889436
29positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.37272755
30signal transduction involved in cell cycle checkpoint (GO:0072395)3.33592515
31rRNA modification (GO:0000154)3.32149936
32S-adenosylmethionine metabolic process (GO:0046500)3.30076237
33respiratory chain complex IV assembly (GO:0008535)3.29520467
34kynurenine metabolic process (GO:0070189)3.25742153
35iron-sulfur cluster assembly (GO:0016226)3.21436030
36metallo-sulfur cluster assembly (GO:0031163)3.21436030
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.21204237
38negative regulation of ligase activity (GO:0051352)3.21204237
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19759006
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.17827655
41positive thymic T cell selection (GO:0045059)3.07839417
42fucose catabolic process (GO:0019317)3.03674247
43L-fucose metabolic process (GO:0042354)3.03674247
44L-fucose catabolic process (GO:0042355)3.03674247
45antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99714035
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.99347763
47electron transport chain (GO:0022900)2.98368378
48indole-containing compound catabolic process (GO:0042436)2.97604639
49indolalkylamine catabolic process (GO:0046218)2.97604639
50tryptophan catabolic process (GO:0006569)2.97604639
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95864614
52cytochrome complex assembly (GO:0017004)2.89396394
53respiratory electron transport chain (GO:0022904)2.87916976
54negative regulation by host of viral transcription (GO:0043922)2.87664550
55rRNA methylation (GO:0031167)2.84413600
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84029656
57tryptophan metabolic process (GO:0006568)2.81872346
58GPI anchor metabolic process (GO:0006505)2.81195538
59positive regulation of ligase activity (GO:0051351)2.79973009
60protein complex biogenesis (GO:0070271)2.78909241
61positive regulation of defense response to virus by host (GO:0002230)2.77542855
62antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.76121283
63mannosylation (GO:0097502)2.73533289
64positive regulation of cell cycle arrest (GO:0071158)2.73083144
65regulation of cellular amine metabolic process (GO:0033238)2.73000768
66positive regulation of prostaglandin secretion (GO:0032308)2.71777859
67piRNA metabolic process (GO:0034587)2.70269468
68GPI anchor biosynthetic process (GO:0006506)2.68950899
69response to pheromone (GO:0019236)2.68740507
70immunoglobulin mediated immune response (GO:0016064)2.66944997
71DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.65224005
72regulation of interleukin-8 secretion (GO:2000482)2.64891479
73platelet dense granule organization (GO:0060155)2.64397225
74sulfation (GO:0051923)2.64301079
75pyrimidine nucleoside catabolic process (GO:0046135)2.64109197
76mitochondrial respiratory chain complex assembly (GO:0033108)2.62035231
77purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.60606364
78cullin deneddylation (GO:0010388)2.58905331
79termination of RNA polymerase III transcription (GO:0006386)2.57529633
80transcription elongation from RNA polymerase III promoter (GO:0006385)2.57529633
81B cell mediated immunity (GO:0019724)2.55713748
82negative regulation of mast cell activation (GO:0033004)2.54596306
83positive regulation of uterine smooth muscle contraction (GO:0070474)2.53437677
84indolalkylamine metabolic process (GO:0006586)2.52617316
85positive regulation of monocyte chemotaxis (GO:0090026)2.50002656
86antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48285387
87protein deneddylation (GO:0000338)2.43940603
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.40250758
89positive regulation of fatty acid transport (GO:2000193)2.40064157
90positive regulation of interleukin-8 secretion (GO:2000484)2.39457773
91tRNA processing (GO:0008033)2.39340842
92peptidyl-histidine modification (GO:0018202)2.37207464
93pseudouridine synthesis (GO:0001522)2.36608231
94negative regulation of T cell apoptotic process (GO:0070233)2.35503099
95positive regulation of calcium-mediated signaling (GO:0050850)2.34615588
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.33906942
97regulation of cell cycle arrest (GO:0071156)2.33680058
98rRNA catabolic process (GO:0016075)2.32463680
99proton transport (GO:0015992)2.32353930
100regulation of ubiquitin-protein transferase activity (GO:0051438)2.31713523

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.27510784
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.88596471
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.80598603
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54533734
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.38609606
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.09556104
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.97854823
8VDR_22108803_ChIP-Seq_LS180_Human2.92235885
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87910547
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84140852
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.81488377
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.76009427
13ZNF274_21170338_ChIP-Seq_K562_Hela2.73263152
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.46203686
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45828256
16VDR_23849224_ChIP-Seq_CD4+_Human2.40370054
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.32409977
18ELK1_19687146_ChIP-ChIP_HELA_Human2.30103390
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.26338888
20IGF1R_20145208_ChIP-Seq_DFB_Human2.19977658
21FOXP3_21729870_ChIP-Seq_TREG_Human2.19719777
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15863281
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.13490685
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12265088
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09102816
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.02092841
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.97559316
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.78186942
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.78026610
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73256504
31CREB1_15753290_ChIP-ChIP_HEK293T_Human1.70362629
32MYC_18940864_ChIP-ChIP_HL60_Human1.66146461
33GATA3_26560356_Chip-Seq_TH2_Human1.62457447
34TP53_22573176_ChIP-Seq_HFKS_Human1.59433177
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.59421945
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52648108
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.49598791
38IRF1_19129219_ChIP-ChIP_H3396_Human1.49500675
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48100010
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46798234
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45587209
42AR_20517297_ChIP-Seq_VCAP_Human1.45023000
43EWS_26573619_Chip-Seq_HEK293_Human1.41825056
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34551894
45SOX2_19829295_ChIP-Seq_ESCs_Human1.31162898
46NANOG_19829295_ChIP-Seq_ESCs_Human1.31162898
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29049693
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25585954
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25206762
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24867783
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23976244
52NOTCH1_21737748_ChIP-Seq_TLL_Human1.23027202
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22693647
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22474948
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22464705
56NCOR_22424771_ChIP-Seq_293T_Human1.22122518
57FUS_26573619_Chip-Seq_HEK293_Human1.21349666
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20460581
59MYB_26560356_Chip-Seq_TH2_Human1.20326302
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19072547
61FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18245928
62FOXA1_25329375_ChIP-Seq_VCAP_Human1.18245928
63TAF15_26573619_Chip-Seq_HEK293_Human1.17656725
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.16031312
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.15397359
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13093610
67GABP_19822575_ChIP-Seq_HepG2_Human1.11823438
68GATA3_27048872_Chip-Seq_THYMUS_Human1.08763126
69PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07457887
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06452031
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05792989
72TAF2_19829295_ChIP-Seq_ESCs_Human1.05440318
73FOXH1_21741376_ChIP-Seq_EPCs_Human1.04704351
74CBP_20019798_ChIP-Seq_JUKART_Human1.04322626
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04322626
76ER_23166858_ChIP-Seq_MCF-7_Human1.04024805
77CIITA_25753668_ChIP-Seq_RAJI_Human1.03653777
78GATA3_26560356_Chip-Seq_TH1_Human1.03358338
79RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.02836479
80SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02646461
81ELK1_22589737_ChIP-Seq_MCF10A_Human1.02490780
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.02360559
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00398198
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99726072
85HOXB7_26014856_ChIP-Seq_BT474_Human0.99199980
86EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98775445
87FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98638442
88POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98365325
89NANOG_20526341_ChIP-Seq_ESCs_Human0.98069955
90GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98020595
91DCP1A_22483619_ChIP-Seq_HELA_Human0.97687555
92P300_19829295_ChIP-Seq_ESCs_Human0.96934042
93HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96766456
94ERA_21632823_ChIP-Seq_H3396_Human0.96128738
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95807433
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95512306
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95340942
98MYC_19829295_ChIP-Seq_ESCs_Human0.95198860
99CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94420423
100ERG_20517297_ChIP-Seq_VCAP_Human0.92491538

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.60233076
2MP0003806_abnormal_nucleotide_metabolis3.50877485
3MP0000372_irregular_coat_pigmentation3.02867507
4MP0005084_abnormal_gallbladder_morpholo2.91941270
5MP0002138_abnormal_hepatobiliary_system2.82843646
6MP0002102_abnormal_ear_morphology2.64987403
7MP0005646_abnormal_pituitary_gland2.42518163
8MP0008875_abnormal_xenobiotic_pharmacok2.36623266
9MP0008872_abnormal_physiological_respon2.33427363
10MP0001835_abnormal_antigen_presentation2.31733279
11MP0008058_abnormal_DNA_repair2.13643357
12MP0002148_abnormal_hypersensitivity_rea2.10653088
13MP0002163_abnormal_gland_morphology2.08050621
14MP0006072_abnormal_retinal_apoptosis1.93066059
15MP0005075_abnormal_melanosome_morpholog1.91457095
16MP0003011_delayed_dark_adaptation1.87251882
17MP0009785_altered_susceptibility_to1.85116988
18MP0001800_abnormal_humoral_immune1.67647774
19MP0005551_abnormal_eye_electrophysiolog1.65201695
20MP0006036_abnormal_mitochondrial_physio1.64284170
21MP0003866_abnormal_defecation1.63799997
22MP0003693_abnormal_embryo_hatching1.62083052
23MP0004145_abnormal_muscle_electrophysio1.58316452
24MP0004043_abnormal_pH_regulation1.57564142
25MP0003880_abnormal_central_pattern1.53631304
26MP0005000_abnormal_immune_tolerance1.52589200
27MP0006082_CNS_inflammation1.51199595
28MP0005085_abnormal_gallbladder_physiolo1.47454514
29MP0001968_abnormal_touch/_nociception1.46437635
30MP0005410_abnormal_fertilization1.44133796
31MP0001986_abnormal_taste_sensitivity1.43988378
32MP0008995_early_reproductive_senescence1.43578928
33MP0003195_calcinosis1.42041924
34MP0006276_abnormal_autonomic_nervous1.40365444
35MP0002723_abnormal_immune_serum1.39984366
36MP0010094_abnormal_chromosome_stability1.39371907
37MP0003718_maternal_effect1.39218656
38MP0010386_abnormal_urinary_bladder1.36181328
39MP0002452_abnormal_antigen_presenting1.33366231
40MP0005253_abnormal_eye_physiology1.32262054
41MP0003786_premature_aging1.31319810
42MP0005645_abnormal_hypothalamus_physiol1.29921003
43MP0005332_abnormal_amino_acid1.29236714
44MP0002006_tumorigenesis1.28031969
45MP0001819_abnormal_immune_cell1.27802704
46MP0002277_abnormal_respiratory_mucosa1.27606198
47MP0003724_increased_susceptibility_to1.27303748
48MP0002166_altered_tumor_susceptibility1.27136820
49MP0002420_abnormal_adaptive_immunity1.26367423
50MP0002876_abnormal_thyroid_physiology1.19143679
51MP0001764_abnormal_homeostasis1.18197386
52MP0006035_abnormal_mitochondrial_morpho1.17611553
53MP0001790_abnormal_immune_system1.16677488
54MP0005387_immune_system_phenotype1.16677488
55MP0005025_abnormal_response_to1.15162947
56MP0000685_abnormal_immune_system1.13592344
57MP0005379_endocrine/exocrine_gland_phen1.12018939
58MP0004147_increased_porphyrin_level1.09142026
59MP0003646_muscle_fatigue1.08610227
60MP0010155_abnormal_intestine_physiology1.07754606
61MP0006292_abnormal_olfactory_placode1.07530744
62MP0001873_stomach_inflammation1.07379815
63MP0009333_abnormal_splenocyte_physiolog1.07367469
64MP0005389_reproductive_system_phenotype1.06554846
65MP0005377_hearing/vestibular/ear_phenot1.06401625
66MP0003878_abnormal_ear_physiology1.06401625
67MP0008877_abnormal_DNA_methylation1.01118375
68MP0005360_urolithiasis1.00766840
69MP0002160_abnormal_reproductive_system0.99578957
70MP0003763_abnormal_thymus_physiology0.98337382
71MP0002139_abnormal_hepatobiliary_system0.96119985
72MP0003183_abnormal_peptide_metabolism0.96003384
73MP0001845_abnormal_inflammatory_respons0.93955658
74MP0000716_abnormal_immune_system0.93295699
75MP0008469_abnormal_protein_level0.93284414
76MP0002736_abnormal_nociception_after0.93190643
77MP0002095_abnormal_skin_pigmentation0.92999062
78MP0000689_abnormal_spleen_morphology0.89733841
79MP0002398_abnormal_bone_marrow0.87851440
80MP0002733_abnormal_thermal_nociception0.87380329
81MP0009764_decreased_sensitivity_to0.86585149
82MP0005636_abnormal_mineral_homeostasis0.86447116
83MP0001970_abnormal_pain_threshold0.85912907
84MP0001905_abnormal_dopamine_level0.84759358
85MP0001919_abnormal_reproductive_system0.84534355
86MP0010329_abnormal_lipoprotein_level0.83857491
87MP0002396_abnormal_hematopoietic_system0.82328316
88MP0009643_abnormal_urine_homeostasis0.82311256
89MP0001666_abnormal_nutrient_absorption0.80471504
90MP0001929_abnormal_gametogenesis0.78188047
91MP0005670_abnormal_white_adipose0.75783826
92MP0005464_abnormal_platelet_physiology0.75763640
93MP0002272_abnormal_nervous_system0.74731519
94MP0009745_abnormal_behavioral_response0.74688232
95MP0000230_abnormal_systemic_arterial0.74497968
96MP0005167_abnormal_blood-brain_barrier0.74281190
97MP0003137_abnormal_impulse_conducting0.73031456
98MP0002429_abnormal_blood_cell0.72697174
99MP0002735_abnormal_chemical_nociception0.72043601
100MP0002933_joint_inflammation0.70331334

Predicted human phenotypes

RankGene SetZ-score
1Hypoproteinemia (HP:0003075)4.07934880
2Acute necrotizing encephalopathy (HP:0006965)3.67875722
3Mitochondrial inheritance (HP:0001427)3.64263759
4Hepatocellular necrosis (HP:0001404)3.58596318
5Increased CSF lactate (HP:0002490)3.57900048
6Abnormal mitochondria in muscle tissue (HP:0008316)3.52401691
7Abolished electroretinogram (ERG) (HP:0000550)3.48662067
8Pancreatic cysts (HP:0001737)3.43638122
9Acute encephalopathy (HP:0006846)3.34346215
10Hepatic necrosis (HP:0002605)3.29440286
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21363119
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21363119
13Progressive macrocephaly (HP:0004481)3.13781101
14Pancreatic fibrosis (HP:0100732)3.12428065
15Increased intramyocellular lipid droplets (HP:0012240)3.10859190
16Aplastic anemia (HP:0001915)3.09525789
173-Methylglutaconic aciduria (HP:0003535)3.07749923
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.04814883
19True hermaphroditism (HP:0010459)3.01894190
20Abnormality of the prostate (HP:0008775)2.96380913
21Abnormality of midbrain morphology (HP:0002418)2.84088174
22Molar tooth sign on MRI (HP:0002419)2.84088174
23Increased serum lactate (HP:0002151)2.74767264
24Attenuation of retinal blood vessels (HP:0007843)2.73137086
25IgG deficiency (HP:0004315)2.72965567
26Increased hepatocellular lipid droplets (HP:0006565)2.70305845
27Type 2 muscle fiber atrophy (HP:0003554)2.69821700
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.67865693
29Abnormality of alanine metabolism (HP:0010916)2.67865693
30Hyperalaninemia (HP:0003348)2.67865693
31Type I transferrin isoform profile (HP:0003642)2.60465238
32Increased muscle lipid content (HP:0009058)2.55054953
33J-shaped sella turcica (HP:0002680)2.50701717
34Abnormality of the pons (HP:0007361)2.50399253
35Lipid accumulation in hepatocytes (HP:0006561)2.49899642
36Lactic acidosis (HP:0003128)2.48497150
37Congenital stationary night blindness (HP:0007642)2.46114140
38Panhypogammaglobulinemia (HP:0003139)2.46045921
39Generalized aminoaciduria (HP:0002909)2.42729991
40Carpal bone hypoplasia (HP:0001498)2.41885782
41Hypoplasia of the pons (HP:0012110)2.40232853
42Abnormality of T cell number (HP:0011839)2.36623386
43Reduced antithrombin III activity (HP:0001976)2.36199458
44Decreased central vision (HP:0007663)2.35118998
45Cerebral edema (HP:0002181)2.34803315
46T lymphocytopenia (HP:0005403)2.31869002
47Renal Fanconi syndrome (HP:0001994)2.30925031
48Optic disc pallor (HP:0000543)2.30420202
49Pendular nystagmus (HP:0012043)2.25948521
50Oral leukoplakia (HP:0002745)2.25373170
51Gaze-evoked nystagmus (HP:0000640)2.23917188
52Muscle fiber atrophy (HP:0100295)2.21829707
53Nephronophthisis (HP:0000090)2.20275237
54Severe combined immunodeficiency (HP:0004430)2.19310439
55Abnormality of the renal cortex (HP:0011035)2.17802998
56Methylmalonic acidemia (HP:0002912)2.17089210
57Abnormal biliary tract physiology (HP:0012439)2.13911338
58Bile duct proliferation (HP:0001408)2.13911338
59Dyschromatopsia (HP:0007641)2.07630541
60Renal cortical cysts (HP:0000803)2.03942159
61Lethargy (HP:0001254)2.03478222
62Cerebral palsy (HP:0100021)2.03392798
63Meckel diverticulum (HP:0002245)2.03299528
64Respiratory failure (HP:0002878)2.02844338
65Delayed CNS myelination (HP:0002188)2.02840985
66Abnormality of the ileum (HP:0001549)2.01370534
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.99465406
68Abnormal protein N-linked glycosylation (HP:0012347)1.99465406
69Abnormal protein glycosylation (HP:0012346)1.99465406
70Abnormal glycosylation (HP:0012345)1.99465406
71Hypothermia (HP:0002045)1.96193489
72Hypoalbuminemia (HP:0003073)1.96107152
73Abnormal albumin level (HP:0012116)1.96107152
74Opisthotonus (HP:0002179)1.95297550
75Thyroiditis (HP:0100646)1.95183597
76Abnormality of B cell number (HP:0010975)1.95153792
77Hypoplasia of the fovea (HP:0007750)1.94990540
78Aplasia/Hypoplasia of the fovea (HP:0008060)1.94990540
79Exertional dyspnea (HP:0002875)1.94364630
80Exercise intolerance (HP:0003546)1.94305002
81Hyperglycinuria (HP:0003108)1.94110771
82Methylmalonic aciduria (HP:0012120)1.90143934
83Autoimmune hemolytic anemia (HP:0001890)1.90078832
84Cystic liver disease (HP:0006706)1.88876507
85Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87205379
86Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83587677
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83326701
88Abnormality of T cells (HP:0002843)1.81320929
89CNS demyelination (HP:0007305)1.80914449
90Abnormality of the renal medulla (HP:0100957)1.80640173
91Abnormal delayed hypersensitivity skin test (HP:0002963)1.80558369
92Keratoconus (HP:0000563)1.80179167
93Increased corneal curvature (HP:0100692)1.80179167
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.79750931
95Aplasia/Hypoplasia of the uvula (HP:0010293)1.78629119
96Stomach cancer (HP:0012126)1.78516094
97Sclerocornea (HP:0000647)1.76784483
98Abnormality of eosinophils (HP:0001879)1.76500404
99Cleft eyelid (HP:0000625)1.76365549
100Medial flaring of the eyebrow (HP:0010747)1.75602567

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.40334030
2TAOK33.38452310
3ZAK3.35607052
4TLK13.26894621
5TXK3.17246417
6NUAK13.09391224
7VRK23.00980127
8ADRBK22.79163241
9KDR2.40147461
10MST42.24842955
11STK162.18016221
12BUB12.09449609
13VRK12.08792925
14MUSK1.91170179
15GRK11.85815509
16FRK1.71253864
17MAP3K121.69852322
18PINK11.67650135
19EIF2AK31.64192898
20BCKDK1.60112580
21TRIM281.52265438
22DAPK11.41596605
23ITK1.41354313
24KIT1.37594899
25SRPK11.34040699
26TIE11.25884336
27CDK191.24475642
28BMPR21.21122829
29TESK21.20192910
30WNK41.11988108
31FES1.10942552
32CAMKK21.08551762
33SYK1.08396317
34CSNK1G31.07492867
35MYLK1.03233659
36FLT30.99250422
37PDK20.96125346
38TNK20.95032349
39PLK30.93180019
40CSNK1A1L0.92064746
41BMPR1B0.91884231
42OXSR10.91540185
43CSNK1G10.90220039
44MAPKAPK30.89154489
45NME10.89004121
46CSNK1G20.86223872
47TSSK60.86167279
48PHKG20.84941117
49PHKG10.84941117
50EPHA40.84274535
51TEC0.83697622
52WNK30.80744404
53PRKCQ0.80117271
54CSF1R0.78989039
55TAF10.78876877
56INSRR0.78429368
57MKNK10.78388984
58IKBKE0.77673932
59IKBKB0.75589871
60PIK3CG0.75275259
61ERBB30.74952253
62BRSK20.73314003
63MAPKAPK50.73311861
64DAPK20.71314896
65TRPM70.67085702
66LYN0.64572892
67MATK0.62071408
68GRK70.61826689
69MAP4K10.61444305
70PLK40.60605671
71PIK3CA0.59210729
72JAK30.57694906
73LCK0.56947633
74ADRBK10.56920376
75MAPK130.56335985
76CDK80.56302639
77RPS6KA50.55444332
78IRAK20.55306849
79MAP2K60.55273311
80BLK0.55160562
81ATR0.54787645
82MAP3K50.54628904
83RIPK40.53921590
84MAP3K40.52001697
85AURKB0.49642260
86BTK0.49534710
87SCYL20.48407403
88PLK20.47521155
89TBK10.47107827
90PLK10.45583534
91DYRK20.43285080
92DAPK30.41226059
93CSNK1A10.38859948
94EIF2AK20.37841104
95IGF1R0.37736520
96CSNK2A10.35658183
97OBSCN0.35495367
98PRKCE0.35127877
99GRK50.34464062
100BCR0.32215777

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.27911455
2Asthma_Homo sapiens_hsa053103.49841154
3Allograft rejection_Homo sapiens_hsa053303.37528672
4Graft-versus-host disease_Homo sapiens_hsa053323.35805880
5Autoimmune thyroid disease_Homo sapiens_hsa053203.33727111
6Type I diabetes mellitus_Homo sapiens_hsa049402.84797439
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.72503992
8Oxidative phosphorylation_Homo sapiens_hsa001902.43735113
9Primary immunodeficiency_Homo sapiens_hsa053402.23077095
10Antigen processing and presentation_Homo sapiens_hsa046122.04507310
11Parkinsons disease_Homo sapiens_hsa050122.02670242
12Homologous recombination_Homo sapiens_hsa034401.90037006
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.89018607
14Rheumatoid arthritis_Homo sapiens_hsa053231.86393830
15Non-homologous end-joining_Homo sapiens_hsa034501.84306938
16Mismatch repair_Homo sapiens_hsa034301.77324704
17RNA polymerase_Homo sapiens_hsa030201.73833422
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.68105122
19One carbon pool by folate_Homo sapiens_hsa006701.58406676
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.53344701
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47208976
22Protein export_Homo sapiens_hsa030601.45922208
23Staphylococcus aureus infection_Homo sapiens_hsa051501.36886067
24DNA replication_Homo sapiens_hsa030301.34775125
25Phototransduction_Homo sapiens_hsa047441.32292829
26Linoleic acid metabolism_Homo sapiens_hsa005911.31797488
27Propanoate metabolism_Homo sapiens_hsa006401.31585169
28RNA degradation_Homo sapiens_hsa030181.27966340
29Viral myocarditis_Homo sapiens_hsa054161.27076739
30Ribosome_Homo sapiens_hsa030101.23463260
31Hematopoietic cell lineage_Homo sapiens_hsa046401.15082429
32Systemic lupus erythematosus_Homo sapiens_hsa053221.10766302
33Fanconi anemia pathway_Homo sapiens_hsa034601.09813597
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09585907
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09062531
36Peroxisome_Homo sapiens_hsa041461.08217373
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07378456
38Tryptophan metabolism_Homo sapiens_hsa003801.05706942
39Huntingtons disease_Homo sapiens_hsa050161.04865821
40Nitrogen metabolism_Homo sapiens_hsa009101.04398165
41Basal transcription factors_Homo sapiens_hsa030221.01425994
42Alzheimers disease_Homo sapiens_hsa050101.01343694
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.99361245
44Nucleotide excision repair_Homo sapiens_hsa034200.97200045
45Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97001528
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94931264
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92463231
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92431010
49Butanoate metabolism_Homo sapiens_hsa006500.92344329
50RNA transport_Homo sapiens_hsa030130.86442649
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85885933
52Retinol metabolism_Homo sapiens_hsa008300.85186117
53Pyrimidine metabolism_Homo sapiens_hsa002400.83063802
54Chemical carcinogenesis_Homo sapiens_hsa052040.82263137
55Sulfur metabolism_Homo sapiens_hsa009200.81795871
56Base excision repair_Homo sapiens_hsa034100.80205477
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79262130
58Regulation of autophagy_Homo sapiens_hsa041400.79108994
59Pyruvate metabolism_Homo sapiens_hsa006200.76573896
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.75114805
61Purine metabolism_Homo sapiens_hsa002300.73243729
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72682891
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72058869
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72058311
65Ether lipid metabolism_Homo sapiens_hsa005650.71980762
66Leishmaniasis_Homo sapiens_hsa051400.71171190
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70450559
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.68704574
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67148017
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66842216
71Collecting duct acid secretion_Homo sapiens_hsa049660.65251323
72Spliceosome_Homo sapiens_hsa030400.65155169
73Caffeine metabolism_Homo sapiens_hsa002320.63745822
74Selenocompound metabolism_Homo sapiens_hsa004500.63588900
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.61653643
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61298185
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57924359
78Arachidonic acid metabolism_Homo sapiens_hsa005900.56483702
79Cardiac muscle contraction_Homo sapiens_hsa042600.56475893
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56102697
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54182855
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47811556
83Metabolic pathways_Homo sapiens_hsa011000.47434621
84Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46902013
85Fat digestion and absorption_Homo sapiens_hsa049750.44666516
86Olfactory transduction_Homo sapiens_hsa047400.43772418
87Epstein-Barr virus infection_Homo sapiens_hsa051690.43218772
88Cyanoamino acid metabolism_Homo sapiens_hsa004600.42917360
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42883413
90Fatty acid degradation_Homo sapiens_hsa000710.42691684
91Herpes simplex infection_Homo sapiens_hsa051680.40409495
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.36785555
93beta-Alanine metabolism_Homo sapiens_hsa004100.35863028
94Fatty acid elongation_Homo sapiens_hsa000620.35417914
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31463390
96Nicotine addiction_Homo sapiens_hsa050330.29283379
97Taste transduction_Homo sapiens_hsa047420.27853357
98Salivary secretion_Homo sapiens_hsa049700.27757743
99Starch and sucrose metabolism_Homo sapiens_hsa005000.24908260
100Glutathione metabolism_Homo sapiens_hsa004800.22553616

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