RBMX2P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)5.86801540
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.86478446
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.75015912
4viral transcription (GO:0019083)5.71285502
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.38596473
6ATP synthesis coupled proton transport (GO:0015986)5.38596473
7cell wall macromolecule metabolic process (GO:0044036)5.35038790
8translational termination (GO:0006415)5.33332929
9respiratory electron transport chain (GO:0022904)5.24855283
10electron transport chain (GO:0022900)5.13339215
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.09778290
12cotranslational protein targeting to membrane (GO:0006613)4.97078623
13protein targeting to ER (GO:0045047)4.91783252
14protein localization to endoplasmic reticulum (GO:0070972)4.74575118
15ribosomal large subunit biogenesis (GO:0042273)4.73038838
16ribosomal small subunit assembly (GO:0000028)4.70403914
17establishment of protein localization to endoplasmic reticulum (GO:0072599)4.63382941
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.46445588
19translational elongation (GO:0006414)4.41172409
20cellular response to leptin stimulus (GO:0044320)4.39325369
21aldehyde catabolic process (GO:0046185)4.36528513
22cell wall macromolecule catabolic process (GO:0016998)4.16310995
23translational initiation (GO:0006413)4.10196034
24viral life cycle (GO:0019058)4.08085874
25chaperone-mediated protein transport (GO:0072321)4.06739785
26nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05700341
27cellular protein complex disassembly (GO:0043624)4.01848290
28hydrogen ion transmembrane transport (GO:1902600)3.77531530
29DNA damage response, detection of DNA damage (GO:0042769)3.77113565
30response to leptin (GO:0044321)3.75606777
31cullin deneddylation (GO:0010388)3.75447085
32axonemal dynein complex assembly (GO:0070286)3.72528303
33protein neddylation (GO:0045116)3.66004696
34regulation of oxidative phosphorylation (GO:0002082)3.62285839
35proton transport (GO:0015992)3.61554427
36regulation of cytokine production involved in inflammatory response (GO:1900015)3.57191786
37hydrogen transport (GO:0006818)3.54091624
38transcription elongation from RNA polymerase III promoter (GO:0006385)3.50854910
39termination of RNA polymerase III transcription (GO:0006386)3.50854910
40proteasome assembly (GO:0043248)3.45845249
41inner mitochondrial membrane organization (GO:0007007)3.44372127
42negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.40086517
43nonmotile primary cilium assembly (GO:0035058)3.38706879
44striatum development (GO:0021756)3.34878921
45dendritic spine morphogenesis (GO:0060997)3.34652814
46regulation of cilium movement (GO:0003352)3.31253460
47protein complex disassembly (GO:0043241)3.28830475
48DNA deamination (GO:0045006)3.26960231
49translation (GO:0006412)3.25621341
50protein localization to mitochondrion (GO:0070585)3.25219512
51regulation of pigment cell differentiation (GO:0050932)3.20860855
52negative regulation of transcription regulatory region DNA binding (GO:2000678)3.19770572
53macromolecular complex disassembly (GO:0032984)3.15847419
54protein-cofactor linkage (GO:0018065)3.14940287
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14521042
56negative regulation of T cell differentiation in thymus (GO:0033085)3.13205995
57viral protein processing (GO:0019082)3.11340940
58negative regulation of response to food (GO:0032096)3.10375457
59negative regulation of appetite (GO:0032099)3.10375457
60inner ear receptor cell development (GO:0060119)3.08884954
61ATP hydrolysis coupled proton transport (GO:0015991)3.08867138
62energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.08867138
63protein targeting to membrane (GO:0006612)3.07405744
64protein deneddylation (GO:0000338)3.05929180
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.01038122
66negative regulation of macrophage differentiation (GO:0045650)3.00564095
67ATP biosynthetic process (GO:0006754)2.94983626
68negative regulation of heart rate (GO:0010459)2.91637792
69cilium movement (GO:0003341)2.90455256
70regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)2.89192889
71maturation of SSU-rRNA (GO:0030490)2.87111051
72mitochondrial respiratory chain complex I assembly (GO:0032981)2.86112299
73NADH dehydrogenase complex assembly (GO:0010257)2.86112299
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.86112299
75protein targeting to mitochondrion (GO:0006626)2.85007036
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83890949
77purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82298083
78mRNA catabolic process (GO:0006402)2.82008743
79positive regulation of histone H3-K4 methylation (GO:0051571)2.81864785
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.80881676
81establishment of protein localization to mitochondrion (GO:0072655)2.80813221
82protein complex biogenesis (GO:0070271)2.80003933
83regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.79916030
84regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.79804217
85centriole replication (GO:0007099)2.79065376
86cellular respiration (GO:0045333)2.78707700
87positive regulation of developmental pigmentation (GO:0048087)2.77066042
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.76678551
89regulation of immunoglobulin secretion (GO:0051023)2.75489988
90tyrosine metabolic process (GO:0006570)2.75215686
91pre-miRNA processing (GO:0031054)2.70325600
92single strand break repair (GO:0000012)2.68932562
93negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.68893597
94regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.63367378
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60638109
96artery smooth muscle contraction (GO:0014824)2.58280521
97RNA catabolic process (GO:0006401)2.57577359
98regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.56710016
99regulation of appetite (GO:0032098)2.56377848
100negative regulation of calcium ion transport into cytosol (GO:0010523)2.54429420

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.08711803
2STAT6_21828071_ChIP-Seq_BEAS2B_Human3.99628703
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.58033822
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.55826499
5IGF1R_20145208_ChIP-Seq_DFB_Human3.46121886
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.43671985
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.37983126
8EZH2_22144423_ChIP-Seq_EOC_Human3.37414426
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.94374314
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58537677
11ZNF274_21170338_ChIP-Seq_K562_Hela2.52086664
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.31561470
13IRF1_19129219_ChIP-ChIP_H3396_Human2.29575435
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.23081752
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.16995369
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08484887
17ELK1_19687146_ChIP-ChIP_HELA_Human2.04700504
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.00999312
19VDR_23849224_ChIP-Seq_CD4+_Human1.92283150
20ERG_20517297_ChIP-Seq_VCAP_Human1.83270884
21ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82760510
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78238675
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70285215
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.67515144
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66055699
26P300_19829295_ChIP-Seq_ESCs_Human1.65876782
27VDR_22108803_ChIP-Seq_LS180_Human1.63465261
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61796061
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60796443
30GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.59819340
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.59465872
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57654196
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.56029224
34FOXP3_21729870_ChIP-Seq_TREG_Human1.53992130
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52215148
36PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51854861
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51310243
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47503792
39REST_21632747_ChIP-Seq_MESCs_Mouse1.46907466
40TP53_22573176_ChIP-Seq_HFKS_Human1.40201875
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39692244
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.37648523
43MYC_18940864_ChIP-ChIP_HL60_Human1.36423426
44FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.33755626
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.33170563
46FUS_26573619_Chip-Seq_HEK293_Human1.30571680
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30081806
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30081806
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28879111
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28864360
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.28217364
52EWS_26573619_Chip-Seq_HEK293_Human1.25407631
53PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.24579939
54E2F1_18555785_Chip-Seq_ESCs_Mouse1.24412070
55RNF2_27304074_Chip-Seq_NSC_Mouse1.23519570
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.23090829
57EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22201144
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.22177743
59FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22177743
60TTF2_22483619_ChIP-Seq_HELA_Human1.21885069
61P53_22387025_ChIP-Seq_ESCs_Mouse1.20347727
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19015684
63CTCF_18555785_Chip-Seq_ESCs_Mouse1.15452354
64CMYC_18555785_Chip-Seq_ESCs_Mouse1.13295937
65P300_18555785_Chip-Seq_ESCs_Mouse1.11701187
66SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11587758
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10470228
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.10452602
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.05769899
70OCT4_18555785_Chip-Seq_ESCs_Mouse1.05579868
71JUN_21703547_ChIP-Seq_K562_Human1.04823455
72EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04039793
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03365335
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03242663
75KLF4_18555785_Chip-Seq_ESCs_Mouse1.02995123
76POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02802488
77BCAT_22108803_ChIP-Seq_LS180_Human1.02796588
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02636402
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02502827
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.02210818
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01977042
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01807893
83PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.01472807
84ZFX_18555785_Chip-Seq_ESCs_Mouse1.00693739
85ER_23166858_ChIP-Seq_MCF-7_Human1.00434086
86SRF_21415370_ChIP-Seq_HL-1_Mouse0.99475440
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99444097
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.99308924
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97476247
90CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97375433
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.97326331
92E2F4_17652178_ChIP-ChIP_JURKAT_Human0.97263345
93MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97091307
94HOXB7_26014856_ChIP-Seq_BT474_Human0.96241507
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96240032
96SOX2_18555785_Chip-Seq_ESCs_Mouse0.96010176
97AR_25329375_ChIP-Seq_VCAP_Human0.95489177
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95344582
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95300162
100TCF4_22108803_ChIP-Seq_LS180_Human0.95295109

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.35574760
2MP0009379_abnormal_foot_pigmentation3.96766849
3MP0006292_abnormal_olfactory_placode3.38605133
4MP0005360_urolithiasis3.26720323
5MP0001529_abnormal_vocalization2.95052893
6MP0008789_abnormal_olfactory_epithelium2.91187818
7MP0003646_muscle_fatigue2.63240364
8MP0005394_taste/olfaction_phenotype2.61675462
9MP0005499_abnormal_olfactory_system2.61675462
10MP0005075_abnormal_melanosome_morpholog2.53088049
11MP0005646_abnormal_pituitary_gland2.41939927
12MP0004858_abnormal_nervous_system2.30191308
13MP0002837_dystrophic_cardiac_calcinosis2.24197160
14MP0009697_abnormal_copulation2.22611327
15MP0001984_abnormal_olfaction2.19174500
16MP0001188_hyperpigmentation2.18195907
17MP0004381_abnormal_hair_follicle2.03750433
18MP0008877_abnormal_DNA_methylation2.00210876
19MP0002277_abnormal_respiratory_mucosa1.93325212
20MP0003806_abnormal_nucleotide_metabolis1.89310401
21MP0002938_white_spotting1.76011032
22MP0006072_abnormal_retinal_apoptosis1.68301565
23MP0008875_abnormal_xenobiotic_pharmacok1.60150555
24MP0002102_abnormal_ear_morphology1.59163606
25MP0002163_abnormal_gland_morphology1.56536038
26MP0000750_abnormal_muscle_regeneration1.54483924
27MP0003186_abnormal_redox_activity1.52045408
28MP0000372_irregular_coat_pigmentation1.50656765
29MP0002095_abnormal_skin_pigmentation1.50599053
30MP0001835_abnormal_antigen_presentation1.50573602
31MP0003121_genomic_imprinting1.48635714
32MP0002822_catalepsy1.42650562
33MP0003122_maternal_imprinting1.38875766
34MP0005171_absent_coat_pigmentation1.36884897
35MP0008872_abnormal_physiological_respon1.35171516
36MP0003787_abnormal_imprinting1.33141649
37MP0001440_abnormal_grooming_behavior1.29306374
38MP0002272_abnormal_nervous_system1.29017726
39MP0003011_delayed_dark_adaptation1.28985007
40MP0001968_abnormal_touch/_nociception1.28203851
41MP0005645_abnormal_hypothalamus_physiol1.23308128
42MP0005379_endocrine/exocrine_gland_phen1.22922860
43MP0004147_increased_porphyrin_level1.21304889
44MP0002736_abnormal_nociception_after1.20382858
45MP0005551_abnormal_eye_electrophysiolog1.19351765
46MP0003195_calcinosis1.15270316
47MP0004859_abnormal_synaptic_plasticity1.14697544
48MP0001905_abnormal_dopamine_level1.13960367
49MP0009785_altered_susceptibility_to1.13173390
50MP0004142_abnormal_muscle_tone1.07435639
51MP0002557_abnormal_social/conspecific_i1.03874395
52MP0005387_immune_system_phenotype1.02260135
53MP0001790_abnormal_immune_system1.02260135
54MP0005253_abnormal_eye_physiology1.01662481
55MP0004145_abnormal_muscle_electrophysio0.99877220
56MP0009046_muscle_twitch0.99119060
57MP0000778_abnormal_nervous_system0.97717168
58MP0009764_decreased_sensitivity_to0.97524699
59MP0009745_abnormal_behavioral_response0.96679718
60MP0001485_abnormal_pinna_reflex0.95555837
61MP0003718_maternal_effect0.94049595
62MP0002572_abnormal_emotion/affect_behav0.93853563
63MP0005332_abnormal_amino_acid0.92746450
64MP0005671_abnormal_response_to0.92587354
65MP0006276_abnormal_autonomic_nervous0.92392409
66MP0006036_abnormal_mitochondrial_physio0.92092180
67MP0002751_abnormal_autonomic_nervous0.90607969
68MP0002090_abnormal_vision0.90306111
69MP0002933_joint_inflammation0.88588224
70MP0002733_abnormal_thermal_nociception0.88208336
71MP0005636_abnormal_mineral_homeostasis0.87824943
72MP0003123_paternal_imprinting0.87774488
73MP0003866_abnormal_defecation0.86752186
74MP0001970_abnormal_pain_threshold0.86472671
75MP0005266_abnormal_metabolism0.81345552
76MP0002184_abnormal_innervation0.81326179
77MP0002752_abnormal_somatic_nervous0.80303803
78MP0005195_abnormal_posterior_eye0.77249065
79MP0000230_abnormal_systemic_arterial0.76981605
80MP0000685_abnormal_immune_system0.76171624
81MP0005386_behavior/neurological_phenoty0.74948657
82MP0004924_abnormal_behavior0.74948657
83MP0001663_abnormal_digestive_system0.74107856
84MP0005389_reproductive_system_phenotype0.73979254
85MP0001764_abnormal_homeostasis0.73367975
86MP0005503_abnormal_tendon_morphology0.73350380
87MP0002653_abnormal_ependyma_morphology0.72477490
88MP0001286_abnormal_eye_development0.72220610
89MP0008058_abnormal_DNA_repair0.71223186
90MP0008873_increased_physiological_sensi0.71197630
91MP0001486_abnormal_startle_reflex0.70973056
92MP0001765_abnormal_ion_homeostasis0.70879930
93MP0001756_abnormal_urination0.70275215
94MP0002332_abnormal_exercise_endurance0.69069598
95MP0000920_abnormal_myelination0.66913145
96MP0001919_abnormal_reproductive_system0.66010943
97MP0002063_abnormal_learning/memory/cond0.65877446
98MP0003635_abnormal_synaptic_transmissio0.65767930
99MP0005423_abnormal_somatic_nervous0.65390290
100MP0010386_abnormal_urinary_bladder0.63269741

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.46525919
2Abnormal mitochondria in muscle tissue (HP:0008316)4.66782432
3Hypoglycemic seizures (HP:0002173)4.66496618
4Progressive macrocephaly (HP:0004481)4.58538101
5Mitochondrial inheritance (HP:0001427)4.37916063
6Congenital, generalized hypertrichosis (HP:0004540)4.32446870
7Acute encephalopathy (HP:0006846)4.26667156
8Increased hepatocellular lipid droplets (HP:0006565)4.13139068
9Hypothermia (HP:0002045)4.06789439
10Reticulocytopenia (HP:0001896)4.04692631
11Increased CSF lactate (HP:0002490)3.97838637
12Hepatocellular necrosis (HP:0001404)3.93216443
13Rectovaginal fistula (HP:0000143)3.86779727
14Rectal fistula (HP:0100590)3.86779727
15Hepatic necrosis (HP:0002605)3.73271905
16Cerebral edema (HP:0002181)3.69301994
17Lipid accumulation in hepatocytes (HP:0006561)3.60088515
18Abnormal ciliary motility (HP:0012262)3.43475820
19Myokymia (HP:0002411)3.34831981
20Renal Fanconi syndrome (HP:0001994)3.30908214
21Macrocytic anemia (HP:0001972)3.30619223
223-Methylglutaconic aciduria (HP:0003535)3.27661623
23Hypoglycemic coma (HP:0001325)3.24733247
24Intestinal fistula (HP:0100819)3.11211318
25Symptomatic seizures (HP:0011145)3.07472565
26Vaginal fistula (HP:0004320)3.07348470
27Median cleft lip (HP:0000161)3.00036938
28Stomatitis (HP:0010280)2.99221793
29Abnormality of cells of the erythroid lineage (HP:0012130)2.98398801
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.88782420
31Exertional dyspnea (HP:0002875)2.88335350
32Methylmalonic acidemia (HP:0002912)2.85515554
33Leukodystrophy (HP:0002415)2.85186724
34Medial flaring of the eyebrow (HP:0010747)2.82999861
35Dyschromatopsia (HP:0007641)2.82311296
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.77421165
37Optic disc pallor (HP:0000543)2.74130118
38Cheilitis (HP:0100825)2.72206506
39Abnormal respiratory motile cilium physiology (HP:0012261)2.66700873
40Abnormal rod and cone electroretinograms (HP:0008323)2.57786964
41Abnormal number of erythroid precursors (HP:0012131)2.52874450
42Abnormality of midbrain morphology (HP:0002418)2.50443191
43Molar tooth sign on MRI (HP:0002419)2.50443191
44Hyperinsulinemic hypoglycemia (HP:0000825)2.50055156
45Decreased central vision (HP:0007663)2.49653079
46Woolly hair (HP:0002224)2.46846465
47Pallor (HP:0000980)2.44497242
48Abnormality of renal resorption (HP:0011038)2.36756056
49Abnormality of urine glucose concentration (HP:0011016)2.35555890
50Glycosuria (HP:0003076)2.35555890
51Renal cortical cysts (HP:0000803)2.31635526
52Duplicated collecting system (HP:0000081)2.30324404
53Gait imbalance (HP:0002141)2.29220394
54Increased intramyocellular lipid droplets (HP:0012240)2.28563511
55Abnormal hemoglobin (HP:0011902)2.28421356
56Respiratory failure (HP:0002878)2.24530368
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24384846
58Abnormality of the renal collecting system (HP:0004742)2.22439527
59Nephrogenic diabetes insipidus (HP:0009806)2.19802440
60Methylmalonic aciduria (HP:0012120)2.17908904
61Neutropenia (HP:0001875)2.17047655
62Respiratory difficulties (HP:0002880)2.14664130
63Congenital primary aphakia (HP:0007707)2.13551263
64Hypoplastic left heart (HP:0004383)2.11559783
65Absent thumb (HP:0009777)2.10598224
66Chronic sinusitis (HP:0011109)2.10420345
67Generalized aminoaciduria (HP:0002909)2.08863412
68Pancreatic cysts (HP:0001737)2.08072557
69Microvesicular hepatic steatosis (HP:0001414)2.04117858
70Congenital stationary night blindness (HP:0007642)2.03584783
71Lactic acidosis (HP:0003128)2.03355531
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.02018076
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.02018076
74Bony spicule pigmentary retinopathy (HP:0007737)2.01694852
75Hyperphosphaturia (HP:0003109)1.99465959
76Constricted visual fields (HP:0001133)1.97455449
77Porencephaly (HP:0002132)1.94997434
78Abnormality of methionine metabolism (HP:0010901)1.92381472
79Central scotoma (HP:0000603)1.91791292
80Hydroureter (HP:0000072)1.89482783
81Megaloblastic anemia (HP:0001889)1.88762523
82Septate vagina (HP:0001153)1.86462735
83Abnormality of the vitamin B12 metabolism (HP:0004341)1.86183446
84Increased serum lactate (HP:0002151)1.85811027
85Postaxial foot polydactyly (HP:0001830)1.84870957
86Partial duplication of thumb phalanx (HP:0009944)1.84298047
87Abnormality of DNA repair (HP:0003254)1.81487954
88Ketosis (HP:0001946)1.80977616
89Exercise intolerance (HP:0003546)1.80063078
90Hyperglycinuria (HP:0003108)1.78235118
91Hypoplastic heart (HP:0001961)1.77633095
92Duplication of thumb phalanx (HP:0009942)1.75796944
93Lethargy (HP:0001254)1.75768840
94Abnormality of dicarboxylic acid metabolism (HP:0010995)1.75211442
95Dicarboxylic aciduria (HP:0003215)1.75211442
96Abolished electroretinogram (ERG) (HP:0000550)1.73035515
97Increased muscle lipid content (HP:0009058)1.72815564
98Febrile seizures (HP:0002373)1.72525421
99Ketoacidosis (HP:0001993)1.72514911
100Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.71856280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM282.87919955
2STK162.87733057
3TXK2.80332293
4NUAK12.78974509
5WNK32.70767489
6MAP4K22.68348468
7SRPK12.66324629
8NEK12.53569203
9BMPR22.49911982
10INSRR2.35415127
11VRK22.33122109
12WNK42.18502193
13TLK12.14584746
14PASK1.88798728
15EPHB11.87512064
16DYRK21.78820475
17PHKG11.66477274
18PHKG21.66477274
19STK391.60443395
20PINK11.59128468
21VRK11.59116619
22ZAK1.51973512
23TIE11.50682871
24FRK1.47960323
25MAP2K21.43732845
26CDK191.40501417
27MARK11.40244079
28MAP3K121.39164053
29EPHB21.38620389
30BRAF1.24447216
31OXSR11.22635636
32EIF2AK31.20206188
33DAPK11.17364770
34TESK11.16243011
35RPS6KA51.14173614
36GRK11.11121495
37TNK21.08379385
38ADRBK21.02605560
39IKBKE1.00252640
40TAOK30.98423034
41NME10.97624968
42CCNB10.94778657
43LIMK10.92847877
44CAMK10.90465433
45MAPK130.88445429
46IRAK20.87234060
47PIK3CA0.86511842
48PLK30.79005486
49IKBKB0.78202800
50MST40.77761354
51ILK0.77444027
52PRKCG0.76244743
53WNK10.76074374
54PNCK0.75700766
55RPS6KA40.72672652
56KIT0.72144896
57RIPK40.71803331
58DAPK30.69975849
59CDK80.67726819
60IRAK10.67140664
61PIK3CG0.65540583
62MINK10.62649321
63OBSCN0.60571929
64SYK0.59580285
65CSF1R0.58983718
66RPS6KA60.58026351
67LATS10.54436930
68PAK30.54040352
69ABL20.53158554
70MYLK0.53145505
71DAPK20.51623934
72PKN10.50794356
73CASK0.50793676
74ERBB20.49002989
75CAMKK10.47345748
76NME20.47234987
77CDK30.47216371
78KSR10.46852008
79PLK40.46752000
80BCKDK0.45245752
81DYRK1A0.45131494
82CSNK1G30.44328611
83RPS6KC10.44295276
84RPS6KL10.44295276
85NTRK30.43880666
86TEC0.43073112
87TGFBR10.42236651
88PRKACA0.40196121
89PRKG10.39546755
90CHEK20.39422506
91CSNK2A20.39392101
92EPHA40.38277516
93CAMK1G0.37843251
94PLK20.37385333
95CAMK2A0.36666081
96IGF1R0.36220092
97EGFR0.35464063
98CSNK1A1L0.35083538
99CSNK2A10.35047934
100MARK30.34717778

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.39411685
2Ribosome_Homo sapiens_hsa030104.77601876
3Parkinsons disease_Homo sapiens_hsa050124.46511657
4Protein export_Homo sapiens_hsa030603.99387237
5Proteasome_Homo sapiens_hsa030503.12967374
6Alzheimers disease_Homo sapiens_hsa050103.08134009
7Huntingtons disease_Homo sapiens_hsa050162.98263246
8Caffeine metabolism_Homo sapiens_hsa002322.95156955
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.73582901
10RNA polymerase_Homo sapiens_hsa030202.58319657
11Asthma_Homo sapiens_hsa053102.56490378
12Cardiac muscle contraction_Homo sapiens_hsa042602.54074035
13Collecting duct acid secretion_Homo sapiens_hsa049661.82703979
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.73252250
15Non-homologous end-joining_Homo sapiens_hsa034501.71637077
16Autoimmune thyroid disease_Homo sapiens_hsa053201.69089002
17Allograft rejection_Homo sapiens_hsa053301.63146782
18Phototransduction_Homo sapiens_hsa047441.53860769
19Homologous recombination_Homo sapiens_hsa034401.39075634
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.36519863
21Rheumatoid arthritis_Homo sapiens_hsa053231.34871178
22Spliceosome_Homo sapiens_hsa030401.34456179
23RNA degradation_Homo sapiens_hsa030181.33137635
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22644079
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22401302
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.17781087
27DNA replication_Homo sapiens_hsa030301.17535106
28Sulfur relay system_Homo sapiens_hsa041221.14529620
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12795648
30Mismatch repair_Homo sapiens_hsa034301.11105625
31Nicotine addiction_Homo sapiens_hsa050331.10345619
32Graft-versus-host disease_Homo sapiens_hsa053321.02023552
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00645041
34Olfactory transduction_Homo sapiens_hsa047400.89753945
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89631844
36Nitrogen metabolism_Homo sapiens_hsa009100.85009982
37Type I diabetes mellitus_Homo sapiens_hsa049400.82469359
38Synaptic vesicle cycle_Homo sapiens_hsa047210.80079828
39Propanoate metabolism_Homo sapiens_hsa006400.79435768
40Linoleic acid metabolism_Homo sapiens_hsa005910.77662967
41Chemical carcinogenesis_Homo sapiens_hsa052040.74491666
42Mineral absorption_Homo sapiens_hsa049780.73770670
43Morphine addiction_Homo sapiens_hsa050320.73714754
44Vibrio cholerae infection_Homo sapiens_hsa051100.72311269
45Tryptophan metabolism_Homo sapiens_hsa003800.69964994
46Insulin secretion_Homo sapiens_hsa049110.68973213
47Pyrimidine metabolism_Homo sapiens_hsa002400.67743374
48Fanconi anemia pathway_Homo sapiens_hsa034600.65362381
49GABAergic synapse_Homo sapiens_hsa047270.64871595
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.64206182
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63946172
52Purine metabolism_Homo sapiens_hsa002300.62554875
53RNA transport_Homo sapiens_hsa030130.58712131
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58195913
55Salivary secretion_Homo sapiens_hsa049700.56473051
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55633186
57Cysteine and methionine metabolism_Homo sapiens_hsa002700.54418823
58Viral myocarditis_Homo sapiens_hsa054160.53615218
59Systemic lupus erythematosus_Homo sapiens_hsa053220.52548033
60Metabolic pathways_Homo sapiens_hsa011000.51461801
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48876307
62NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48576787
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.48329371
64Starch and sucrose metabolism_Homo sapiens_hsa005000.47301689
65Taste transduction_Homo sapiens_hsa047420.46870814
66beta-Alanine metabolism_Homo sapiens_hsa004100.45890306
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45462406
68Regulation of autophagy_Homo sapiens_hsa041400.45399679
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44500394
70Serotonergic synapse_Homo sapiens_hsa047260.43243980
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.42930273
72Primary immunodeficiency_Homo sapiens_hsa053400.42640806
73Peroxisome_Homo sapiens_hsa041460.41443263
74Nucleotide excision repair_Homo sapiens_hsa034200.41332861
75Ether lipid metabolism_Homo sapiens_hsa005650.39951731
76Arachidonic acid metabolism_Homo sapiens_hsa005900.39366342
77Circadian entrainment_Homo sapiens_hsa047130.37246790
78Retinol metabolism_Homo sapiens_hsa008300.36026669
79Steroid biosynthesis_Homo sapiens_hsa001000.34543466
80Vitamin B6 metabolism_Homo sapiens_hsa007500.34238488
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33911344
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31718339
83Phagosome_Homo sapiens_hsa041450.29062281
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28766570
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.28560929
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28001933
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26806979
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25575000
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25471978
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.24222334
91Glutamatergic synapse_Homo sapiens_hsa047240.23378886
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.22799969
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.21983455
94Tyrosine metabolism_Homo sapiens_hsa003500.21136025
95African trypanosomiasis_Homo sapiens_hsa051430.19787003
96Staphylococcus aureus infection_Homo sapiens_hsa051500.19171660
97Antigen processing and presentation_Homo sapiens_hsa046120.19036548
98Butanoate metabolism_Homo sapiens_hsa006500.18097438
99Pancreatic secretion_Homo sapiens_hsa049720.16898473
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.13880143

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