RBMX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.35186117
2daunorubicin metabolic process (GO:0044597)7.35186117
3polyketide metabolic process (GO:0030638)7.35186117
4protein localization to kinetochore (GO:0034501)5.95898972
5regulation of nuclear cell cycle DNA replication (GO:0033262)5.54654590
6viral transcription (GO:0019083)5.37256079
7translational termination (GO:0006415)5.23488730
8DNA replication checkpoint (GO:0000076)5.18538026
9negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.12272610
10regulation of telomere maintenance via telomerase (GO:0032210)5.10981481
11mitotic sister chromatid segregation (GO:0000070)4.95857031
12rRNA transcription (GO:0009303)4.88331490
13ribosomal small subunit assembly (GO:0000028)4.78858618
14DNA replication-dependent nucleosome organization (GO:0034723)4.69401271
15DNA replication-dependent nucleosome assembly (GO:0006335)4.69401271
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.69201422
17negative regulation of cell cycle G2/M phase transition (GO:1902750)4.69152160
18rRNA modification (GO:0000154)4.67753422
19histone H4-K12 acetylation (GO:0043983)4.65665628
20protein localization to chromosome, centromeric region (GO:0071459)4.64902785
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.64766327
22ribosomal large subunit biogenesis (GO:0042273)4.64045653
23regulation of mammary gland epithelial cell proliferation (GO:0033599)4.62063588
24cotranslational protein targeting to membrane (GO:0006613)4.61060039
25aminoglycoside antibiotic metabolic process (GO:0030647)4.60895419
26somite rostral/caudal axis specification (GO:0032525)4.58272562
27maintenance of protein location in nucleus (GO:0051457)4.58212608
28protein targeting to ER (GO:0045047)4.54053873
29negative regulation of epidermis development (GO:0045683)4.46954275
30rRNA methylation (GO:0031167)4.46703646
31establishment of protein localization to mitochondrial membrane (GO:0090151)4.43295709
32translational elongation (GO:0006414)4.39475815
33establishment of protein localization to endoplasmic reticulum (GO:0072599)4.37753014
34negative regulation of telomerase activity (GO:0051974)4.35070587
35regulation of DNA methylation (GO:0044030)4.31587956
36translational initiation (GO:0006413)4.23794546
37protein localization to endoplasmic reticulum (GO:0070972)4.23684679
38cullin deneddylation (GO:0010388)4.20195772
39sister chromatid segregation (GO:0000819)4.15716094
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.13676012
41histone H4-K8 acetylation (GO:0043982)4.13263513
42histone H4-K5 acetylation (GO:0043981)4.13263513
43chaperone-mediated protein transport (GO:0072321)4.06257043
44formation of translation preinitiation complex (GO:0001731)4.06065761
45ATP synthesis coupled proton transport (GO:0015986)4.05323636
46energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05323636
47viral life cycle (GO:0019058)4.04332667
48cellular protein complex disassembly (GO:0043624)4.02701894
49ribosome biogenesis (GO:0042254)4.01166295
50heterochromatin organization (GO:0070828)3.97326905
51nuclear pore complex assembly (GO:0051292)3.96869175
52negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.96746023
53proteasome assembly (GO:0043248)3.96397313
54negative regulation of telomere maintenance (GO:0032205)3.95336600
55regulation of translation in response to stress (GO:0043555)3.92426077
56muscle organ morphogenesis (GO:0048644)3.91699759
57ribosomal small subunit biogenesis (GO:0042274)3.90327909
58DNA replication-independent nucleosome assembly (GO:0006336)3.88064784
59DNA replication-independent nucleosome organization (GO:0034724)3.88064784
60centriole replication (GO:0007099)3.86779064
61pseudouridine synthesis (GO:0001522)3.86175748
62regulation of response to osmotic stress (GO:0047484)3.85103050
63histone exchange (GO:0043486)3.83745049
64positive regulation of histone H3-K4 methylation (GO:0051571)3.83277245
65mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.83089054
66positive regulation of DNA-dependent DNA replication (GO:2000105)3.82395077
67piRNA metabolic process (GO:0034587)3.81671876
68protein deneddylation (GO:0000338)3.79917655
69regulation of meiosis I (GO:0060631)3.78701080
70negative regulation of epidermal cell differentiation (GO:0045605)3.74705496
71DNA replication initiation (GO:0006270)3.74388137
72nuclear pore organization (GO:0006999)3.72734580
73regulation of cilium movement (GO:0003352)3.72268934
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.72098749
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.67653326
76replication fork processing (GO:0031297)3.59801469
77respiratory electron transport chain (GO:0022904)3.59552419
78chromatin assembly (GO:0031497)3.59017382
79ribonucleoprotein complex biogenesis (GO:0022613)3.56219095
80regulation of MHC class I biosynthetic process (GO:0045343)3.56070222
81DNA damage response, detection of DNA damage (GO:0042769)3.54162386
82electron transport chain (GO:0022900)3.51184218
83anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50962486
84pattern specification involved in kidney development (GO:0061004)3.50390511
85translation (GO:0006412)3.47449761
86DNA unwinding involved in DNA replication (GO:0006268)3.46406919
87protein complex disassembly (GO:0043241)3.46320998
88notochord development (GO:0030903)3.46214883
89meiotic cell cycle (GO:0051321)3.45536757
90nuclear-transcribed mRNA catabolic process (GO:0000956)3.43950779
91metaphase plate congression (GO:0051310)3.42679653
92mitotic chromosome condensation (GO:0007076)3.42251093
93positive regulation of gastrulation (GO:2000543)3.42108216
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35960874
95mitochondrial respiratory chain complex I assembly (GO:0032981)3.35960874
96NADH dehydrogenase complex assembly (GO:0010257)3.35960874
97kinetochore organization (GO:0051383)3.35149641
98macromolecular complex disassembly (GO:0032984)3.33042871
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.32609913
100GDP-mannose metabolic process (GO:0019673)3.30536906
101cell fate commitment involved in formation of primary germ layer (GO:0060795)3.30361175
102protein complex biogenesis (GO:0070271)3.29077580
103protein K6-linked ubiquitination (GO:0085020)3.28695072
104mRNA catabolic process (GO:0006402)3.26460441
105inner mitochondrial membrane organization (GO:0007007)3.25482989
106kinetochore assembly (GO:0051382)3.25298011
107negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25109942
108transcription from mitochondrial promoter (GO:0006390)3.22853664
109mitotic metaphase plate congression (GO:0007080)3.21384927
110regulation of double-strand break repair via homologous recombination (GO:0010569)3.20725134
111quinone metabolic process (GO:1901661)3.20187203
112regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.20077082
113regulation of mitotic spindle checkpoint (GO:1903504)3.20077082
114transcription elongation from RNA polymerase III promoter (GO:0006385)3.18992487
115termination of RNA polymerase III transcription (GO:0006386)3.18992487
116phenol-containing compound catabolic process (GO:0019336)3.18125078
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.18110304
118regulation of telomere maintenance (GO:0032204)3.18021309
119mitochondrial respiratory chain complex assembly (GO:0033108)3.16471025
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13204737
121synapsis (GO:0007129)3.12243510
122DNA duplex unwinding (GO:0032508)3.11642673
123transcription-coupled nucleotide-excision repair (GO:0006283)3.11558836
124regulation of mitochondrial translation (GO:0070129)3.11509435
125regulation of double-strand break repair (GO:2000779)3.10251900
126DNA geometric change (GO:0032392)3.08837968
127spliceosomal complex assembly (GO:0000245)3.05517437
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05393299
129telomere maintenance via recombination (GO:0000722)3.05378873
130nucleoside transmembrane transport (GO:1901642)3.04992163
131pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04296346
132pore complex assembly (GO:0046931)3.04039556
133histone H4-K16 acetylation (GO:0043984)3.01792330
134DNA methylation involved in gamete generation (GO:0043046)3.01746683
135RNA catabolic process (GO:0006401)2.98952460
136mitotic G2/M transition checkpoint (GO:0044818)2.96443673
137spliceosomal snRNP assembly (GO:0000387)2.95897354
138regulation of telomerase activity (GO:0051972)2.95281260
139protein targeting to membrane (GO:0006612)2.95065181
140primitive streak formation (GO:0090009)2.94694017
141mitotic recombination (GO:0006312)2.93812906
142negative regulation of ligase activity (GO:0051352)2.93793037
143negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.93793037
144establishment of chromosome localization (GO:0051303)2.93503976
145cytidine deamination (GO:0009972)2.92182245
146cytidine metabolic process (GO:0046087)2.92182245
147cytidine catabolic process (GO:0006216)2.92182245
148regulation of DNA-dependent DNA replication (GO:0090329)2.92074926
149DNA strand elongation involved in DNA replication (GO:0006271)2.91515614
1507-methylguanosine mRNA capping (GO:0006370)2.91281221
151attachment of spindle microtubules to kinetochore (GO:0008608)2.89443872
152protein targeting to mitochondrion (GO:0006626)2.87083948
153cellular component biogenesis (GO:0044085)2.84841859
154mitotic nuclear envelope disassembly (GO:0007077)2.84420654
155maturation of SSU-rRNA (GO:0030490)2.84333992
156rRNA processing (GO:0006364)2.84069209
157resolution of meiotic recombination intermediates (GO:0000712)2.83601193
158chromatin assembly or disassembly (GO:0006333)2.83457710
159regulation of gene silencing by miRNA (GO:0060964)2.82531425
160regulation of gene silencing by RNA (GO:0060966)2.82531425
161regulation of posttranscriptional gene silencing (GO:0060147)2.82531425
162transcription from RNA polymerase I promoter (GO:0006360)2.81555735
163regulation of apoptotic process involved in morphogenesis (GO:1902337)2.80267347
164telomere maintenance via semi-conservative replication (GO:0032201)2.80077655
165pre-miRNA processing (GO:0031054)2.77084326
166intestinal epithelial cell development (GO:0060576)2.76973517
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.76852185
168intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.76642121
169protein localization to chromosome (GO:0034502)2.75406336
170DNA strand elongation (GO:0022616)2.75215154
171spindle assembly (GO:0051225)2.75069403
172response to dietary excess (GO:0002021)2.75054258
173chromatin remodeling at centromere (GO:0031055)2.74116084
174rRNA metabolic process (GO:0016072)2.73825834
175branching involved in mammary gland duct morphogenesis (GO:0060444)2.73489881
176CENP-A containing nucleosome assembly (GO:0034080)2.72096432
177nucleobase biosynthetic process (GO:0046112)2.69993350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.86454322
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.61723159
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.61723159
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.61723159
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.00083755
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.92569786
7EZH2_22144423_ChIP-Seq_EOC_Human3.51865408
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50946310
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.42545145
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.08819515
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.07341491
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.89517225
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.83526264
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64053869
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.60587116
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.58300341
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52669754
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51519570
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45018205
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40010920
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.38122956
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.36277326
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29585833
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26701544
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.22998184
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.21241471
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20708523
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.06794596
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04989845
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01411405
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95740681
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90357563
33POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.88128994
34TCF3_18692474_ChIP-Seq_MESCs_Mouse1.88006952
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.87918875
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.87221578
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86744322
38MYC_18940864_ChIP-ChIP_HL60_Human1.86548381
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.85651766
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80320177
41NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.77922360
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74065536
43XRN2_22483619_ChIP-Seq_HELA_Human1.73462312
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.68753135
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.66995721
46IRF1_19129219_ChIP-ChIP_H3396_Human1.66993848
47FOXP3_21729870_ChIP-Seq_TREG_Human1.66292428
48HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64515235
49VDR_23849224_ChIP-Seq_CD4+_Human1.63283273
50NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57331293
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53581076
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52859803
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51911849
54KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.51366232
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49942255
56KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.48986977
57TTF2_22483619_ChIP-Seq_HELA_Human1.48908311
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47445765
59NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.42116660
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41472873
61MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40141695
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.38817202
63RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37581862
64* GABP_19822575_ChIP-Seq_HepG2_Human1.37420895
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37133550
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34628556
67EWS_26573619_Chip-Seq_HEK293_Human1.33739047
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33453099
69DCP1A_22483619_ChIP-Seq_HELA_Human1.30389963
70AR_21909140_ChIP-Seq_LNCAP_Human1.30087818
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.28525738
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27626971
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25911272
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25792131
75ELK1_19687146_ChIP-ChIP_HELA_Human1.25389411
76POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23042154
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22579015
78NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20216003
79KDM5A_27292631_Chip-Seq_BREAST_Human1.19465135
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18594609
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16727242
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16668654
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16542000
84NANOG_21062744_ChIP-ChIP_HESCs_Human1.13591934
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13302071
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12401080
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.11788999
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.11551626
89FUS_26573619_Chip-Seq_HEK293_Human1.11533960
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.11076291
91YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10310517
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08513231
93SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08207052
94NANOG_18692474_ChIP-Seq_MESCs_Mouse1.07775756
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06666213
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05219506
97SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05072444
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05066338
99PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04821670
100E2F1_17053090_ChIP-ChIP_MCF-7_Human1.03556356
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.02641074
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02557750
103CIITA_25753668_ChIP-Seq_RAJI_Human1.01910369
104ZNF274_21170338_ChIP-Seq_K562_Hela1.01474160
105E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00360880
106GATA1_26923725_Chip-Seq_HPCs_Mouse0.98505717
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97477105
108MYC_22102868_ChIP-Seq_BL_Human0.95404823
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94879434
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93810953
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93282494
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91722451
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91412423
114VDR_22108803_ChIP-Seq_LS180_Human0.90609681
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89463869
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.89331751
117SRF_21415370_ChIP-Seq_HL-1_Mouse0.88318176
118ELF1_17652178_ChIP-ChIP_JURKAT_Human0.87083003
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.86017485
120SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85201982
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84622245
122SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.84165598
123* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84008307
124TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82993018
125TP53_22573176_ChIP-Seq_HFKS_Human0.81199842
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.80141316
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.79952750
128HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78210318
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77786446
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77233502
131BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76404015
132PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.75826308
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.73635121
134* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.70342087

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.49196126
2MP0006292_abnormal_olfactory_placode4.31843706
3MP0004957_abnormal_blastocyst_morpholog3.85825909
4MP0009379_abnormal_foot_pigmentation3.80780658
5MP0003890_abnormal_embryonic-extraembry3.43974136
6MP0003011_delayed_dark_adaptation3.19460267
7MP0004264_abnormal_extraembryonic_tissu3.07742876
8MP0003693_abnormal_embryo_hatching2.81512389
9MP0010094_abnormal_chromosome_stability2.79334431
10MP0003077_abnormal_cell_cycle2.74386101
11MP0005075_abnormal_melanosome_morpholog2.71378514
12MP0003111_abnormal_nucleus_morphology2.70418875
13MP0005394_taste/olfaction_phenotype2.62811121
14MP0005499_abnormal_olfactory_system2.62811121
15MP0003122_maternal_imprinting2.51451435
16MP0003121_genomic_imprinting2.46434368
17MP0002254_reproductive_system_inflammat2.33887322
18MP0003123_paternal_imprinting2.14984209
19MP0005257_abnormal_intraocular_pressure2.14193544
20MP0008932_abnormal_embryonic_tissue2.11086709
21MP0008058_abnormal_DNA_repair2.03792791
22MP0006035_abnormal_mitochondrial_morpho2.03776101
23MP0002234_abnormal_pharynx_morphology2.00993739
24MP0005380_embryogenesis_phenotype1.96573591
25MP0001672_abnormal_embryogenesis/_devel1.96573591
26MP0000350_abnormal_cell_proliferation1.89181039
27MP0003938_abnormal_ear_development1.83760902
28MP0001529_abnormal_vocalization1.83089113
29MP0002332_abnormal_exercise_endurance1.81750856
30MP0002653_abnormal_ependyma_morphology1.79440896
31MP0001984_abnormal_olfaction1.76955376
32MP0003984_embryonic_growth_retardation1.75342007
33MP0002088_abnormal_embryonic_growth/wei1.74192958
34MP0001293_anophthalmia1.71652870
35MP0003186_abnormal_redox_activity1.68839092
36MP0002277_abnormal_respiratory_mucosa1.63941476
37MP0010352_gastrointestinal_tract_polyps1.63666056
38MP0010030_abnormal_orbit_morphology1.62687338
39MP0001730_embryonic_growth_arrest1.62041954
40MP0002085_abnormal_embryonic_tissue1.60185794
41MP0000678_abnormal_parathyroid_gland1.56182222
42MP0008007_abnormal_cellular_replicative1.55797910
43MP0002160_abnormal_reproductive_system1.53479507
44MP0002138_abnormal_hepatobiliary_system1.52883175
45MP0001929_abnormal_gametogenesis1.51954971
46MP0002638_abnormal_pupillary_reflex1.51434360
47MP0003786_premature_aging1.51373490
48MP0003315_abnormal_perineum_morphology1.49877168
49MP0000049_abnormal_middle_ear1.47829440
50MP0004133_heterotaxia1.47000877
51MP0003941_abnormal_skin_development1.46096918
52MP0002396_abnormal_hematopoietic_system1.45300671
53MP0008789_abnormal_olfactory_epithelium1.44535351
54MP0002127_abnormal_cardiovascular_syste1.44238537
55MP0000631_abnormal_neuroendocrine_gland1.44179423
56MP0000653_abnormal_sex_gland1.43598901
57MP0002084_abnormal_developmental_patter1.41207626
58MP0004858_abnormal_nervous_system1.40510652
59MP0004142_abnormal_muscle_tone1.39493703
60MP0001697_abnormal_embryo_size1.36442517
61MP0005395_other_phenotype1.33154597
62MP0002086_abnormal_extraembryonic_tissu1.31823042
63MP0000566_synostosis1.31540162
64MP0003119_abnormal_digestive_system1.30744710
65MP0002932_abnormal_joint_morphology1.22623062
66MP0002102_abnormal_ear_morphology1.22576030
67MP0000313_abnormal_cell_death1.21399473
68MP0005389_reproductive_system_phenotype1.21345060
69MP0000762_abnormal_tongue_morphology1.19260643
70MP0002751_abnormal_autonomic_nervous1.18585919
71MP0000372_irregular_coat_pigmentation1.17961285
72MP0008995_early_reproductive_senescence1.17717464
73MP0002092_abnormal_eye_morphology1.17185770
74MP0002080_prenatal_lethality1.16649419
75MP0000490_abnormal_crypts_of1.16600296
76MP0003567_abnormal_fetal_cardiomyocyte1.12535189
77MP0003699_abnormal_female_reproductive1.11971003
78MP0002095_abnormal_skin_pigmentation1.11951974
79MP0006276_abnormal_autonomic_nervous1.11122062
80MP0004197_abnormal_fetal_growth/weight/1.08664158
81MP0002114_abnormal_axial_skeleton1.08465018
82MP0000428_abnormal_craniofacial_morphol1.07648534
83MP0003755_abnormal_palate_morphology1.05273846
84MP0003806_abnormal_nucleotide_metabolis1.04548276
85MP0003880_abnormal_central_pattern1.04244638
86MP0003937_abnormal_limbs/digits/tail_de1.04234976
87MP0005646_abnormal_pituitary_gland1.03994025
88MP0003136_yellow_coat_color1.03747912
89MP0003698_abnormal_male_reproductive1.03293317
90MP0005266_abnormal_metabolism1.01888449
91MP0010307_abnormal_tumor_latency1.01134236
92MP0002233_abnormal_nose_morphology1.00380173
93MP0002161_abnormal_fertility/fecundity1.00351627
94MP0001119_abnormal_female_reproductive0.99165383
95MP0002938_white_spotting0.98933904
96MP0005410_abnormal_fertilization0.98290552
97MP0000432_abnormal_head_morphology0.97993677
98MP0008877_abnormal_DNA_methylation0.93154699
99MP0004381_abnormal_hair_follicle0.93019697
100MP0009697_abnormal_copulation0.92359656
101MP0003787_abnormal_imprinting0.91438857
102MP0003935_abnormal_craniofacial_develop0.90284333
103MP0000778_abnormal_nervous_system0.90065536
104MP0001849_ear_inflammation0.88654990
105MP0001145_abnormal_male_reproductive0.87746695
106MP0005391_vision/eye_phenotype0.87684882
107MP0002132_abnormal_respiratory_system0.87606693
108MP0001188_hyperpigmentation0.86158291
109MP0002163_abnormal_gland_morphology0.85266483
110MP0001286_abnormal_eye_development0.84562993
111MP0001348_abnormal_lacrimal_gland0.80947380
112MP0002116_abnormal_craniofacial_bone0.80647532
113MP0003183_abnormal_peptide_metabolism0.80562396
114MP0005551_abnormal_eye_electrophysiolog0.79832576
115MP0000358_abnormal_cell_content/0.79659097
116MP0003861_abnormal_nervous_system0.79545971
117MP0002210_abnormal_sex_determination0.79206633
118MP0001919_abnormal_reproductive_system0.78631163
119MP0000427_abnormal_hair_cycle0.78270811
120MP0002019_abnormal_tumor_incidence0.77818989
121MP0004043_abnormal_pH_regulation0.74752810
122MP0008770_decreased_survivor_rate0.74375517
123MP0001764_abnormal_homeostasis0.73902914
124MP0006082_CNS_inflammation0.73239139
125MP0001324_abnormal_eye_pigmentation0.72800979
126MP0003718_maternal_effect0.72765211
127MP0002697_abnormal_eye_size0.71806093
128MP0009703_decreased_birth_body0.70708978
129MP0000647_abnormal_sebaceous_gland0.70042954
130MP0003936_abnormal_reproductive_system0.69682620
131MP0005408_hypopigmentation0.69049154
132MP0005195_abnormal_posterior_eye0.68767700
133MP0009250_abnormal_appendicular_skeleto0.68688493
134MP0000750_abnormal_muscle_regeneration0.67968378
135MP0002111_abnormal_tail_morphology0.67757865
136MP0002249_abnormal_larynx_morphology0.66239204
137MP0003705_abnormal_hypodermis_morpholog0.65538754
138MP0005384_cellular_phenotype0.65475636
139MP0006036_abnormal_mitochondrial_physio0.65160400
140MP0002752_abnormal_somatic_nervous0.62587090
141MP0003137_abnormal_impulse_conducting0.62380584
142MP0005508_abnormal_skeleton_morphology0.62367670
143MP0002081_perinatal_lethality0.60613506
144MP0005253_abnormal_eye_physiology0.60526239
145MP0003283_abnormal_digestive_organ0.60192988
146MP0002970_abnormal_white_adipose0.59960296
147MP0006072_abnormal_retinal_apoptosis0.59795058
148MP0005645_abnormal_hypothalamus_physiol0.58832362

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.14989573
2Hypochromic microcytic anemia (HP:0004840)4.93288896
3Multiple enchondromatosis (HP:0005701)4.71894319
4Acute necrotizing encephalopathy (HP:0006965)4.63761537
5Chromosomal breakage induced by crosslinking agents (HP:0003221)4.32834912
6Rib fusion (HP:0000902)4.27740752
7Reticulocytopenia (HP:0001896)4.13043557
8Abnormal mitochondria in muscle tissue (HP:0008316)4.12915440
9Hepatoblastoma (HP:0002884)4.10662507
10Abnormality of cells of the erythroid lineage (HP:0012130)4.03976209
11Chromsome breakage (HP:0040012)3.99389255
12Ependymoma (HP:0002888)3.97628257
13Macrocytic anemia (HP:0001972)3.89221157
14Mitochondrial inheritance (HP:0001427)3.88779082
15Acute encephalopathy (HP:0006846)3.85625821
16Increased hepatocellular lipid droplets (HP:0006565)3.85283072
17Nephroblastoma (Wilms tumor) (HP:0002667)3.77650743
18Progressive macrocephaly (HP:0004481)3.76782005
19Increased CSF lactate (HP:0002490)3.69709044
20Abnormal number of erythroid precursors (HP:0012131)3.58714244
21Embryonal renal neoplasm (HP:0011794)3.51610363
22Lipid accumulation in hepatocytes (HP:0006561)3.51375803
23Rhabdomyosarcoma (HP:0002859)3.47375415
24Rectal fistula (HP:0100590)3.43808417
25Rectovaginal fistula (HP:0000143)3.43808417
26Neoplasm of striated muscle (HP:0009728)3.39384181
27Hepatocellular necrosis (HP:0001404)3.23420762
28Abnormal lung lobation (HP:0002101)3.20651990
29Meckel diverticulum (HP:0002245)3.13677096
30Hepatic necrosis (HP:0002605)3.13655431
31Cerebral edema (HP:0002181)3.12827678
32Renal Fanconi syndrome (HP:0001994)3.10781038
33Hypoplasia of the fovea (HP:0007750)3.09920115
34Aplasia/Hypoplasia of the fovea (HP:0008060)3.09920115
35Septo-optic dysplasia (HP:0100842)3.06819539
36Trismus (HP:0000211)3.05553532
37Abnormality of the ileum (HP:0001549)3.03941911
38Intestinal fistula (HP:0100819)3.01666602
39Fused cervical vertebrae (HP:0002949)3.00896567
40Abnormality of the lower motor neuron (HP:0002366)3.00544645
41Supernumerary spleens (HP:0009799)2.99652876
42Oligodactyly (hands) (HP:0001180)2.95731940
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.88446075
44Impulsivity (HP:0100710)2.85102214
45Aplasia/hypoplasia of the humerus (HP:0006507)2.83346239
46Vaginal fistula (HP:0004320)2.82864312
47Bifid tongue (HP:0010297)2.82723666
48Astrocytoma (HP:0009592)2.79056475
49Abnormality of the astrocytes (HP:0100707)2.79056475
50Partial duplication of thumb phalanx (HP:0009944)2.74488125
513-Methylglutaconic aciduria (HP:0003535)2.72982785
52Testicular atrophy (HP:0000029)2.72627299
53Breast hypoplasia (HP:0003187)2.66701063
54Absent septum pellucidum (HP:0001331)2.62029082
55Pallor (HP:0000980)2.57892533
56Glossoptosis (HP:0000162)2.55344527
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54965931
58Molar tooth sign on MRI (HP:0002419)2.52713296
59Abnormality of midbrain morphology (HP:0002418)2.52713296
60Median cleft lip (HP:0000161)2.51924060
61Short humerus (HP:0005792)2.50246173
62Abnormality of glycolysis (HP:0004366)2.48394059
63Increased serum pyruvate (HP:0003542)2.48394059
64Abnormality of the preputium (HP:0100587)2.47966150
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.45393638
66Anomalous pulmonary venous return (HP:0010772)2.44941872
67Microvesicular hepatic steatosis (HP:0001414)2.43882921
68Ragged-red muscle fibers (HP:0003200)2.42267107
69Medulloblastoma (HP:0002885)2.41582051
70Abnormality of the salivary glands (HP:0010286)2.41222336
71Colon cancer (HP:0003003)2.40478442
72Partial duplication of the phalanx of hand (HP:0009999)2.39043987
73Abnormality of the septum pellucidum (HP:0007375)2.38503504
74Increased serum lactate (HP:0002151)2.38396304
75Respiratory difficulties (HP:0002880)2.37772992
76Aplastic anemia (HP:0001915)2.37070009
77Microretrognathia (HP:0000308)2.37045432
78Medial flaring of the eyebrow (HP:0010747)2.35419597
79Facial hemangioma (HP:0000329)2.35109639
80Small intestinal stenosis (HP:0012848)2.35003878
81Duodenal stenosis (HP:0100867)2.35003878
82Nasolacrimal duct obstruction (HP:0000579)2.34945910
83Birth length less than 3rd percentile (HP:0003561)2.34830893
84Pendular nystagmus (HP:0012043)2.34776949
85Abdominal situs inversus (HP:0003363)2.33926074
86Abnormality of abdominal situs (HP:0011620)2.33926074
87Shawl scrotum (HP:0000049)2.33416814
88Abnormality of the fovea (HP:0000493)2.33401142
89Volvulus (HP:0002580)2.32051292
90Atresia of the external auditory canal (HP:0000413)2.31556498
91Progressive muscle weakness (HP:0003323)2.31080985
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30673392
93Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30673392
94Glioma (HP:0009733)2.29553255
95Aplasia/Hypoplasia of the sternum (HP:0006714)2.28466940
96Lactic acidosis (HP:0003128)2.27242829
97Horseshoe kidney (HP:0000085)2.27063526
98Abnormality of chromosome segregation (HP:0002916)2.26372803
99Increased intramyocellular lipid droplets (HP:0012240)2.26076191
100Generalized aminoaciduria (HP:0002909)2.25062522
101Facial cleft (HP:0002006)2.24537011
102Premature ovarian failure (HP:0008209)2.22121402
103Amyotrophic lateral sclerosis (HP:0007354)2.21788691
104Preauricular skin tag (HP:0000384)2.21413940
105Periauricular skin pits (HP:0100277)2.21008498
106Preauricular pit (HP:0004467)2.21008498
107Absent thumb (HP:0009777)2.19136510
108Type I transferrin isoform profile (HP:0003642)2.18965394
109Secondary amenorrhea (HP:0000869)2.17806254
110Exertional dyspnea (HP:0002875)2.16499191
111Hypochromic anemia (HP:0001931)2.14758483
112Patellar aplasia (HP:0006443)2.14345807
113Respiratory failure (HP:0002878)2.13990227
114Reduced antithrombin III activity (HP:0001976)2.13876953
115Horizontal nystagmus (HP:0000666)2.13234964
116Concave nail (HP:0001598)2.13013600
117Sensory axonal neuropathy (HP:0003390)2.12881852
118Oligodactyly (HP:0012165)2.12821076
119Pancreatic fibrosis (HP:0100732)2.12578675
120Tongue fasciculations (HP:0001308)2.12304965
121Hyperinsulinemic hypoglycemia (HP:0000825)2.11995655
122Exercise intolerance (HP:0003546)2.11513420
123Abnormality of the labia minora (HP:0012880)2.09383729
124Abnormality of chromosome stability (HP:0003220)2.08489895
125Pancreatic cysts (HP:0001737)2.07093272
126Abnormality of the pulmonary veins (HP:0011718)2.05802640
127Duplication of thumb phalanx (HP:0009942)2.04583119
128Abnormality of the phalanges of the hallux (HP:0010057)2.02001959
129Myelodysplasia (HP:0002863)2.01773990
130Absent radius (HP:0003974)2.00650285
131Leukodystrophy (HP:0002415)2.00492470
132Cleft eyelid (HP:0000625)1.99716875
133Abnormality of small intestinal villus morphology (HP:0011472)1.99398270
134Villous atrophy (HP:0011473)1.99398270
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.98985527
136Aplasia/Hypoplasia of the patella (HP:0006498)1.97790368
137Triphalangeal thumb (HP:0001199)1.96783819
138Malignant neoplasm of the central nervous system (HP:0100836)1.94869700
139Progressive external ophthalmoplegia (HP:0000590)1.94859994
140Abnormal biliary tract physiology (HP:0012439)1.94405610
141Bile duct proliferation (HP:0001408)1.94405610
142Sloping forehead (HP:0000340)1.93655256
143Bone marrow hypocellularity (HP:0005528)1.92927783
144Abnormality of the duodenum (HP:0002246)1.92148992
145Abnormality of the pons (HP:0007361)1.92073874
146Hypoplasia of the pons (HP:0012110)1.91192588
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.90591983
148Carpal bone hypoplasia (HP:0001498)1.90561543
149Skin tags (HP:0010609)1.89333534
150Stenosis of the external auditory canal (HP:0000402)1.88867460
151Absent forearm bone (HP:0003953)1.88368630
152Aplasia involving forearm bones (HP:0009822)1.88368630
153Optic disc pallor (HP:0000543)1.86579926
154Abnormality of renal resorption (HP:0011038)1.84952321
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.84877154
156Congenital primary aphakia (HP:0007707)1.83871869
157Type 2 muscle fiber atrophy (HP:0003554)1.83113136
158X-linked dominant inheritance (HP:0001423)1.82961053
159Abnormality of DNA repair (HP:0003254)1.80208156
160Gait imbalance (HP:0002141)1.79306351
161Aganglionic megacolon (HP:0002251)1.76635126
162Myokymia (HP:0002411)1.75054491
163Nephrogenic diabetes insipidus (HP:0009806)1.75012529
164Increased muscle lipid content (HP:0009058)1.73021813
165Gonadotropin excess (HP:0000837)1.72332495
166Short tibia (HP:0005736)1.70501743
167Methylmalonic acidemia (HP:0002912)1.69951678
168Anencephaly (HP:0002323)1.66636984
169Depressed nasal ridge (HP:0000457)1.65765778
170Glycosuria (HP:0003076)1.62959293
171Abnormality of urine glucose concentration (HP:0011016)1.62959293
172Sclerocornea (HP:0000647)1.62690145

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.54100796
2GRK54.19385271
3GRK63.42195467
4TTK3.16754964
5VRK23.10914136
6BUB12.67545173
7ADRBK22.59366509
8ZAK2.52119778
9ERN12.45256589
10GRK12.42255196
11CDC72.40300458
12WEE12.38828173
13ARAF2.32822654
14MAP3K92.29747834
15TYRO32.25234330
16CDK72.16433646
17BMPR1B2.13719684
18CSF1R2.10786019
19GRK72.04727338
20TNIK2.02927852
21STK102.02415138
22CHEK22.00395734
23PLK11.96158048
24MATK1.92743779
25TAOK31.90655056
26SRPK11.87913362
27BRAF1.86993590
28PBK1.81916945
29MAPK71.80410910
30NUAK11.66932468
31MOS1.60812471
32NEK21.54721133
33EPHA21.52129349
34WNK11.48010536
35PDK21.36107864
36STK391.31243945
37TGFBR21.30377030
38CHEK11.26840577
39DYRK31.25897539
40EIF2AK11.20113429
41CDK91.17458931
42AURKB1.13621745
43TRIM281.13041129
44NTRK11.13039910
45VRK11.13017127
46AKT31.12301833
47AURKA1.11859033
48STK241.09401824
49WNK41.06931053
50DYRK21.04659176
51HIPK21.03136377
52BRSK21.02980521
53TLK11.00760491
54MAP3K40.99935790
55TAF10.99508863
56CAMK40.96227470
57TGFBR10.95782814
58TSSK60.93691501
59BCKDK0.92877693
60MST40.92573811
61CLK10.91039790
62PAK40.91015914
63EIF2AK20.90336330
64LATS20.87511233
65PRKG20.86740592
66PLK40.86486285
67ADRBK10.85796728
68TESK20.81848414
69CDK20.80628743
70MARK20.80249691
71NEK60.79301707
72ATM0.78559095
73ATR0.76805215
74CSNK1G10.76095641
75CDK80.74819567
76CDK30.74052844
77DMPK0.73268755
78PRKCI0.73204438
79ACVR1B0.72848957
80EIF2AK30.71567093
81STK160.71186019
82MAP4K20.71160253
83MKNK20.69764205
84CCNB10.69702306
85RPS6KB20.69160879
86PNCK0.68666844
87NME10.68067960
88MAP3K130.65478308
89LRRK20.65302799
90PIM10.64427582
91MKNK10.63419906
92PAK10.61954213
93OXSR10.61414911
94PLK30.61213851
95NME20.61054855
96CSNK1G30.61011140
97MAP2K70.60976229
98AKT20.59165349
99CDK10.58385286
100RAF10.57208060
101MAP3K100.56879181
102CSNK1G20.56705282
103ALK0.55647597
104CDK40.54027617
105ILK0.53489580
106BCR0.52883835
107CSNK1E0.52567029
108PLK20.52364067
109CSK0.51215033
110BRSK10.50622944
111STK30.48700816
112CDK140.46278956
113NEK10.45136798
114NTRK20.45037580
115STK38L0.44914473
116RPS6KA50.42985792
117STK40.42692881
118BRD40.41345861
119MAPK130.40963317
120CSNK2A10.40086206
121MTOR0.39534357
122WNK30.39517141
123MAP3K80.37094755
124YES10.36671445
125MAPK150.34984201
126CSNK1A1L0.33885661
127CDK190.33743061
128CSNK2A20.33630085
129MAP2K40.33627504
130UHMK10.33336280
131PIM20.30441082
132PRKCG0.29893563
133MAP2K60.29372171
134DAPK30.29029945
135PRKACB0.28873899
136MAPK100.28493858
137DYRK1A0.28087204
138GSK3B0.27551649
139CDK11A0.27123627
140MAPK140.26739444
141IKBKB0.25020464
142CDK150.25011571
143BLK0.24943888
144MELK0.24691318
145CDK180.23015819
146ICK0.22315598
147PASK0.20407685

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.65002248
2Vitamin B6 metabolism_Homo sapiens_hsa007503.92976947
3DNA replication_Homo sapiens_hsa030303.73825717
4Ribosome_Homo sapiens_hsa030103.56064277
5Mismatch repair_Homo sapiens_hsa034303.44003756
6RNA polymerase_Homo sapiens_hsa030203.27566341
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.09915617
8RNA transport_Homo sapiens_hsa030132.99076649
9Spliceosome_Homo sapiens_hsa030402.86326893
10Homologous recombination_Homo sapiens_hsa034402.84736773
11Fanconi anemia pathway_Homo sapiens_hsa034602.58417157
12Proteasome_Homo sapiens_hsa030502.50465116
13Cell cycle_Homo sapiens_hsa041102.41682481
14Nucleotide excision repair_Homo sapiens_hsa034202.20659301
15Base excision repair_Homo sapiens_hsa034102.18408585
16RNA degradation_Homo sapiens_hsa030182.02830257
17Fructose and mannose metabolism_Homo sapiens_hsa000511.99819078
18mRNA surveillance pathway_Homo sapiens_hsa030151.95660012
19Pyrimidine metabolism_Homo sapiens_hsa002401.95088716
20Basal transcription factors_Homo sapiens_hsa030221.89518195
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87717903
22Arachidonic acid metabolism_Homo sapiens_hsa005901.68857684
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64547789
24One carbon pool by folate_Homo sapiens_hsa006701.64509854
25Non-homologous end-joining_Homo sapiens_hsa034501.59440133
26Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36709707
27Galactose metabolism_Homo sapiens_hsa000521.33653067
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29915170
29p53 signaling pathway_Homo sapiens_hsa041151.27570378
30Linoleic acid metabolism_Homo sapiens_hsa005911.26742295
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12443404
32Caffeine metabolism_Homo sapiens_hsa002321.12374787
33Folate biosynthesis_Homo sapiens_hsa007901.05052899
34Thyroid cancer_Homo sapiens_hsa052161.03828373
35Purine metabolism_Homo sapiens_hsa002300.99477022
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98999406
37Propanoate metabolism_Homo sapiens_hsa006400.98693765
38Huntingtons disease_Homo sapiens_hsa050160.95372303
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.90678165
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88001646
41Hedgehog signaling pathway_Homo sapiens_hsa043400.87105828
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.86636779
43Oxidative phosphorylation_Homo sapiens_hsa001900.85652384
44Phototransduction_Homo sapiens_hsa047440.85031457
45Pyruvate metabolism_Homo sapiens_hsa006200.80452415
46Parkinsons disease_Homo sapiens_hsa050120.79283034
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78941497
48Oocyte meiosis_Homo sapiens_hsa041140.77511119
49Basal cell carcinoma_Homo sapiens_hsa052170.76839155
50Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75349679
51Fatty acid elongation_Homo sapiens_hsa000620.72875235
52MicroRNAs in cancer_Homo sapiens_hsa052060.71702099
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71686878
54Protein export_Homo sapiens_hsa030600.70827672
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70739990
56Steroid biosynthesis_Homo sapiens_hsa001000.66446182
57Herpes simplex infection_Homo sapiens_hsa051680.64475347
58Epstein-Barr virus infection_Homo sapiens_hsa051690.62821622
59Hippo signaling pathway_Homo sapiens_hsa043900.62513688
60mTOR signaling pathway_Homo sapiens_hsa041500.60796369
61Pentose phosphate pathway_Homo sapiens_hsa000300.60712760
62Collecting duct acid secretion_Homo sapiens_hsa049660.57900924
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55853853
64Ether lipid metabolism_Homo sapiens_hsa005650.55253132
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52329957
66Viral carcinogenesis_Homo sapiens_hsa052030.50795575
67Sulfur relay system_Homo sapiens_hsa041220.49696565
68Wnt signaling pathway_Homo sapiens_hsa043100.49427439
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48458803
70Pathways in cancer_Homo sapiens_hsa052000.48245627
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47330846
72Nicotine addiction_Homo sapiens_hsa050330.47169524
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45212703
74Olfactory transduction_Homo sapiens_hsa047400.44920828
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43788441
76Regulation of autophagy_Homo sapiens_hsa041400.43270314
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43244386
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.43080568
79Systemic lupus erythematosus_Homo sapiens_hsa053220.41884068
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41309436
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38639015
82HTLV-I infection_Homo sapiens_hsa051660.37861745
83Alzheimers disease_Homo sapiens_hsa050100.36807355
84Carbon metabolism_Homo sapiens_hsa012000.36571667
85Bladder cancer_Homo sapiens_hsa052190.35032037
86Metabolic pathways_Homo sapiens_hsa011000.33586630
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31513375
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31053315
89Peroxisome_Homo sapiens_hsa041460.30882351
90Tight junction_Homo sapiens_hsa045300.30849037
91Butanoate metabolism_Homo sapiens_hsa006500.30794293
92Primary immunodeficiency_Homo sapiens_hsa053400.28638026
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.28049904
94TGF-beta signaling pathway_Homo sapiens_hsa043500.27043509
95Notch signaling pathway_Homo sapiens_hsa043300.26844928
96Cardiac muscle contraction_Homo sapiens_hsa042600.26277809
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.26017606
98Other glycan degradation_Homo sapiens_hsa005110.25953868
99Inositol phosphate metabolism_Homo sapiens_hsa005620.25357159
100Alcoholism_Homo sapiens_hsa050340.24573053
101Apoptosis_Homo sapiens_hsa042100.23433137
102Acute myeloid leukemia_Homo sapiens_hsa052210.23282989
103Glutathione metabolism_Homo sapiens_hsa004800.21836719
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.21764876
105Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21585342
106Circadian rhythm_Homo sapiens_hsa047100.21324556
107Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.21101083
108Colorectal cancer_Homo sapiens_hsa052100.19894055
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19488764
110Chemical carcinogenesis_Homo sapiens_hsa052040.18745610
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18230092
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.18195401
113Choline metabolism in cancer_Homo sapiens_hsa052310.17715358
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.16572505
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.16439791
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.15924043
117Biosynthesis of amino acids_Homo sapiens_hsa012300.15005979
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14866756
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.14584018
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13063141
121Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12762589
122Non-small cell lung cancer_Homo sapiens_hsa052230.12262707
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.11966912
124Sulfur metabolism_Homo sapiens_hsa009200.11937991
125Ovarian steroidogenesis_Homo sapiens_hsa049130.11869461
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.11655516
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11415058
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.10982328
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.09679856
130Selenocompound metabolism_Homo sapiens_hsa004500.08564661
131Small cell lung cancer_Homo sapiens_hsa052220.07792445
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.07646819
133Primary bile acid biosynthesis_Homo sapiens_hsa001200.06778574
134Vibrio cholerae infection_Homo sapiens_hsa051100.06192296
135Synaptic vesicle cycle_Homo sapiens_hsa047210.05957570
136Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.05313539
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.01128080
138Vitamin digestion and absorption_Homo sapiens_hsa049770.00778157
139Retinol metabolism_Homo sapiens_hsa00830-6.4427816
140Ascorbate and aldarate metabolism_Homo sapiens_hsa00053-0.0043203

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