RBM46

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1male meiosis (GO:0007140)9.94129399
2regulation of meiosis I (GO:0060631)8.83290289
3cilium or flagellum-dependent cell motility (GO:0001539)8.51586976
4chromosome organization involved in meiosis (GO:0070192)7.55885501
5meiotic nuclear division (GO:0007126)7.43226859
6fusion of sperm to egg plasma membrane (GO:0007342)7.33005234
7male meiosis I (GO:0007141)7.17245080
8histone H3-K9 demethylation (GO:0033169)6.36836374
9sperm motility (GO:0030317)6.26720697
10sperm-egg recognition (GO:0035036)6.23171376
11binding of sperm to zona pellucida (GO:0007339)6.17389703
12acrosome assembly (GO:0001675)6.02457409
13regulation of DNA methylation (GO:0044030)5.89907077
14gene silencing by RNA (GO:0031047)5.89599350
15meiosis I (GO:0007127)5.84603697
16spermatid development (GO:0007286)5.75289087
17axonemal dynein complex assembly (GO:0070286)5.52178266
18cell-cell recognition (GO:0009988)5.49277428
19plasma membrane fusion (GO:0045026)5.34833126
20multicellular organism reproduction (GO:0032504)5.17113277
21epithelial cilium movement (GO:0003351)4.95706393
22positive regulation of meiosis (GO:0045836)4.88110860
23meiotic cell cycle process (GO:1903046)4.86234273
24acrosome reaction (GO:0007340)4.83078746
25regulation of female gonad development (GO:2000194)4.82174775
26DNA alkylation (GO:0006305)4.81098491
27DNA methylation (GO:0006306)4.81098491
28mitotic metaphase plate congression (GO:0007080)4.75470422
29germ cell development (GO:0007281)4.74395683
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.59811236
31meiotic chromosome segregation (GO:0045132)4.55965385
32positive regulation of meiotic cell cycle (GO:0051446)4.54955959
33spermatogenesis (GO:0007283)4.54082610
34male gamete generation (GO:0048232)4.53272380
35nuclear pore complex assembly (GO:0051292)4.52525686
36motile cilium assembly (GO:0044458)4.51290024
37nuclear pore organization (GO:0006999)4.41612247
38centriole replication (GO:0007099)4.35524882
39meiotic cell cycle (GO:0051321)4.35327387
40regulation of meiotic cell cycle (GO:0051445)4.28518220
41cilium movement (GO:0003341)4.21305164
42oogenesis (GO:0048477)4.18477204
43reciprocal meiotic recombination (GO:0007131)4.17766928
44reciprocal DNA recombination (GO:0035825)4.17766928
45sister chromatid cohesion (GO:0007062)4.17551430
46gamete generation (GO:0007276)4.17450916
47cellular process involved in reproduction in multicellular organism (GO:0022412)4.17410590
48retinal cone cell development (GO:0046549)4.16216135
49gene silencing (GO:0016458)4.15480141
50regulation of acrosome reaction (GO:0060046)4.13566622
51positive regulation of histone H3-K4 methylation (GO:0051571)4.09627931
52fertilization (GO:0009566)4.09356018
53protein localization to chromosome (GO:0034502)4.07996524
54reproduction (GO:0000003)4.05820758
55positive regulation of mitotic sister chromatid separation (GO:1901970)4.03044409
56positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.03044409
57positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.03044409
58sex differentiation (GO:0007548)4.02445908
59metaphase plate congression (GO:0051310)3.97933193
60protein localization to kinetochore (GO:0034501)3.97094441
61cell wall macromolecule catabolic process (GO:0016998)3.95413587
62cell wall macromolecule metabolic process (GO:0044036)3.95413587
63gonadal mesoderm development (GO:0007506)3.90941246
64synapsis (GO:0007129)3.89488176
65CENP-A containing nucleosome assembly (GO:0034080)3.89136318
66microtubule depolymerization (GO:0007019)3.86622287
67negative regulation of meiosis (GO:0045835)3.84231652
68monoubiquitinated protein deubiquitination (GO:0035520)3.84063190
69establishment of chromosome localization (GO:0051303)3.75386445
70negative regulation of histone methylation (GO:0031061)3.74106749
71centriole assembly (GO:0098534)3.73391603
72chromatin remodeling at centromere (GO:0031055)3.73314748
73regulation of cilium movement (GO:0003352)3.70915085
74genitalia morphogenesis (GO:0035112)3.70567669
75DNA methylation or demethylation (GO:0044728)3.65505732
76positive regulation of male gonad development (GO:2000020)3.63934182
77single fertilization (GO:0007338)3.63587438
78protein localization to chromosome, centromeric region (GO:0071459)3.59170405
79oocyte development (GO:0048599)3.57750547
80positive regulation of chromosome segregation (GO:0051984)3.54099147
81negative regulation of DNA repair (GO:0045738)3.52955367
82heterochromatin organization (GO:0070828)3.46486479
83regulation of double-strand break repair via homologous recombination (GO:0010569)3.46178082
84pore complex assembly (GO:0046931)3.43519519
85regulation of DNA endoreduplication (GO:0032875)3.40297240
86ventricular system development (GO:0021591)3.39382877
87mitotic sister chromatid cohesion (GO:0007064)3.39007203
88resolution of meiotic recombination intermediates (GO:0000712)3.35303032
89DNA packaging (GO:0006323)3.35281147
90regulation of protein polyubiquitination (GO:1902914)3.25798401
91positive regulation of histone methylation (GO:0031062)3.25193726
92negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.24807881
93multicellular organismal reproductive process (GO:0048609)3.23537404
94intraciliary transport (GO:0042073)3.23272451
95positive regulation of gastrulation (GO:2000543)3.21135240
96negative regulation of reproductive process (GO:2000242)3.20724147
97negative regulation of gene silencing (GO:0060969)3.20601482
98histone lysine demethylation (GO:0070076)3.19350177
99DNA replication-dependent nucleosome organization (GO:0034723)3.17896333
100DNA replication-dependent nucleosome assembly (GO:0006335)3.17896333
101regulation of histone H3-K9 methylation (GO:0051570)3.16268228
102regulation of centriole replication (GO:0046599)3.16123544
103histone exchange (GO:0043486)3.14255905
104primitive streak formation (GO:0090009)3.14087287
105proteasome assembly (GO:0043248)3.13425253
106DNA strand renaturation (GO:0000733)3.10356152
107regulation of cell maturation (GO:1903429)3.06751162
108chaperone-mediated protein complex assembly (GO:0051131)3.06143547
109histone demethylation (GO:0016577)3.04473792
110DNA replication-independent nucleosome assembly (GO:0006336)3.03943245
111DNA replication-independent nucleosome organization (GO:0034724)3.03943245
112spindle checkpoint (GO:0031577)3.02504022
113female gamete generation (GO:0007292)3.02346704
114attachment of spindle microtubules to kinetochore (GO:0008608)3.02178504
115chromosome condensation (GO:0030261)3.00521553
116seminiferous tubule development (GO:0072520)3.00164212
117regulation of chromatin silencing (GO:0031935)2.99867396
118histone H2A acetylation (GO:0043968)2.98927280
119regulation of sister chromatid segregation (GO:0033045)2.98413410
120regulation of mitotic sister chromatid separation (GO:0010965)2.98413410
121regulation of mitotic sister chromatid segregation (GO:0033047)2.98413410
122regulation of male gonad development (GO:2000018)2.98276247
123nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.97524732
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97122637
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97122637
126regulation of gene silencing by RNA (GO:0060966)2.96409338
127regulation of posttranscriptional gene silencing (GO:0060147)2.96409338
128regulation of gene silencing by miRNA (GO:0060964)2.96409338
129DNA modification (GO:0006304)2.93751197
130somite rostral/caudal axis specification (GO:0032525)2.92154703
131DNA damage induced protein phosphorylation (GO:0006975)2.90362030
132regulation of chromosome segregation (GO:0051983)2.90176832
133regulation of histone methylation (GO:0031060)2.89061715
134positive regulation of translational initiation (GO:0045948)2.88906000
135chromosome organization (GO:0051276)2.86700833
136negative regulation of cell cycle G2/M phase transition (GO:1902750)2.86390471
137mitotic spindle checkpoint (GO:0071174)2.86207648
138DNA replication checkpoint (GO:0000076)2.86124940
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85489869
140nuclear division (GO:0000280)2.84699432
141DNA synthesis involved in DNA repair (GO:0000731)2.82954309
142negative regulation of inclusion body assembly (GO:0090084)2.82039401
143regulation of meiosis (GO:0040020)2.81028956
144oocyte maturation (GO:0001556)2.80635323
145mitotic chromosome condensation (GO:0007076)2.77539619
146regulation of RNA export from nucleus (GO:0046831)2.72550359
147protein localization to cilium (GO:0061512)2.70309517
148piRNA metabolic process (GO:0034587)14.6308843
149DNA methylation involved in gamete generation (GO:0043046)11.1616265
150synaptonemal complex assembly (GO:0007130)10.7770491
151synaptonemal complex organization (GO:0070193)10.5251775

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21521317
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.53055623
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.66332809
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.53831977
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.49288108
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83021634
7AR_21909140_ChIP-Seq_LNCAP_Human2.79560352
8EZH2_22144423_ChIP-Seq_EOC_Human2.78971128
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.74121434
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.58421423
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.45700082
12IGF1R_20145208_ChIP-Seq_DFB_Human2.39644841
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.35573464
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.32662621
15RNF2_27304074_Chip-Seq_NSC_Mouse2.30114031
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26059913
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25774391
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10748662
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.08975452
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.9346330
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97505764
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95430895
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.94784681
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.93341024
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.90114089
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.90114089
27KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.90114089
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.85245642
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.84775812
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.78092601
31VDR_22108803_ChIP-Seq_LS180_Human1.64892049
32CBX2_27304074_Chip-Seq_ESCs_Mouse1.62514570
33GBX2_23144817_ChIP-Seq_PC3_Human1.61359133
34IRF1_19129219_ChIP-ChIP_H3396_Human1.59047530
35FUS_26573619_Chip-Seq_HEK293_Human1.54537851
36RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53798653
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50729342
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48656425
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47895875
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.46225896
41ZNF274_21170338_ChIP-Seq_K562_Hela1.45637044
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44653268
43* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44330877
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.43298162
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.42520449
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.40154547
47RUNX1_26923725_Chip-Seq_HPCs_Mouse1.39006070
48P300_19829295_ChIP-Seq_ESCs_Human1.36979685
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34880898
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33705110
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32087818
52RUNX2_22187159_ChIP-Seq_PCA_Human1.30894132
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.29259136
54KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27748711
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.26780434
56MYC_18555785_ChIP-Seq_MESCs_Mouse1.26183266
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26163974
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26079962
59MYC_18940864_ChIP-ChIP_HL60_Human1.25827910
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25655656
61CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23427184
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.19514105
63AR_25329375_ChIP-Seq_VCAP_Human1.18151767
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16788409
65PRDM14_20953172_ChIP-Seq_ESCs_Human1.16616901
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.16026847
67SMAD4_21799915_ChIP-Seq_A2780_Human1.15207730
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15011661
69CBP_20019798_ChIP-Seq_JUKART_Human1.15011661
70MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14113790
71EWS_26573619_Chip-Seq_HEK293_Human1.13414786
72CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10475211
73* SMAD4_21741376_ChIP-Seq_EPCs_Human1.09740865
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.09027114
75CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08815888
76HTT_18923047_ChIP-ChIP_STHdh_Human1.07058544
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06718210
78SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.02785893
79BCAT_22108803_ChIP-Seq_LS180_Human1.02700898
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02280411
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.01820371
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01588988
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.00748280
84FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99996805
85ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98832629
86TP53_22573176_ChIP-Seq_HFKS_Human0.98632609
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98021237
88GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.96363650
89CBP_21632823_ChIP-Seq_H3396_Human0.95991410
90FOXP3_21729870_ChIP-Seq_TREG_Human0.95463963
91VDR_23849224_ChIP-Seq_CD4+_Human0.94306283
92DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93971228
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93357115
94TAL1_26923725_Chip-Seq_HPCs_Mouse0.92640586
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91424178
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90713845
97FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90621590
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90558238
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.90001290
100TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.89948141
101* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89330129
102FOXH1_21741376_ChIP-Seq_EPCs_Human0.89006970
103GATA3_26560356_Chip-Seq_TH1_Human0.88782753
104TCF4_22108803_ChIP-Seq_LS180_Human0.87393633
105SOX2_19829295_ChIP-Seq_ESCs_Human0.86879756
106NANOG_19829295_ChIP-Seq_ESCs_Human0.86879756
107HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.86052752
108* SOX9_26525672_Chip-Seq_HEART_Mouse0.86037844
109CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85420776
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84872006
111NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.84489891
112POU5F1_16153702_ChIP-ChIP_HESCs_Human0.84414825
113ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84413166
114STAT1_17558387_ChIP-Seq_HELA_Human0.84330548
115AUTS2_25519132_ChIP-Seq_293T-REX_Human0.84321416
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83703724
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83163558
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.82473856
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.82258184
120TAF15_26573619_Chip-Seq_HEK293_Human0.81508310
121* TCF4_23295773_ChIP-Seq_U87_Human0.81259748
122PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.79295517
123GF1B_26923725_Chip-Seq_HPCs_Mouse0.79288626
124DCP1A_22483619_ChIP-Seq_HELA_Human0.78100172
125PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77566168
126SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76489721
127SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.75359181
128ETV1_20927104_ChIP-Seq_GIST48_Human0.75264882
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75213646
130GF1_26923725_Chip-Seq_HPCs_Mouse0.74651167
131CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.74373309
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.74021249
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.73323001
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73323001
135TTF2_22483619_ChIP-Seq_HELA_Human0.72554441
136CTBP2_25329375_ChIP-Seq_LNCAP_Human0.72543002
137SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71881133
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71745754
139ER_23166858_ChIP-Seq_MCF-7_Human0.71426175
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.70871141
141KLF5_20875108_ChIP-Seq_MESCs_Mouse0.70631392
142YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.69724713
143CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69691835
144NFYB_21822215_ChIP-Seq_K562_Human0.69519704
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.69237078
146STAT3_23295773_ChIP-Seq_U87_Human0.68705756
147XRN2_22483619_ChIP-Seq_HELA_Human0.67653091
148MYC_19030024_ChIP-ChIP_MESCs_Mouse0.66733361
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.65796647
150GATA3_21867929_ChIP-Seq_CD8_Mouse0.65125729
151REST_19997604_ChIP-ChIP_NEURONS_Mouse0.64487720
152* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.64362969
153OCT4_19829295_ChIP-Seq_ESCs_Human0.64323619
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.64294110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation8.53335844
2MP0005410_abnormal_fertilization6.84826622
3MP0003718_maternal_effect5.62413935
4MP0002653_abnormal_ependyma_morphology4.44026715
5MP0002210_abnormal_sex_determination4.15586093
6MP0001929_abnormal_gametogenesis4.15505287
7MP0003698_abnormal_male_reproductive3.98339169
8MP0006292_abnormal_olfactory_placode3.73403844
9MP0008995_early_reproductive_senescence3.35011271
10MP0001145_abnormal_male_reproductive3.28007073
11MP0000653_abnormal_sex_gland2.92561371
12MP0008057_abnormal_DNA_replication2.91152777
13MP0003123_paternal_imprinting2.73970995
14MP0010094_abnormal_chromosome_stability2.54353852
15MP0003786_premature_aging2.26481619
16MP0002161_abnormal_fertility/fecundity2.22787877
17MP0008058_abnormal_DNA_repair2.11322017
18MP0008438_abnormal_cutaneous_collagen2.05843032
19MP0005395_other_phenotype2.02899057
20MP0005623_abnormal_meninges_morphology1.94739244
21MP0005503_abnormal_tendon_morphology1.89658913
22MP0008007_abnormal_cellular_replicative1.86439648
23MP0003111_abnormal_nucleus_morphology1.70724656
24MP0002160_abnormal_reproductive_system1.69689699
25MP0003183_abnormal_peptide_metabolism1.63155346
26MP0010368_abnormal_lymphatic_system1.62821756
27MP0003121_genomic_imprinting1.61837072
28MP0000678_abnormal_parathyroid_gland1.58298874
29MP0002139_abnormal_hepatobiliary_system1.56176668
30MP0003115_abnormal_respiratory_system1.51143434
31MP0002282_abnormal_trachea_morphology1.47678083
32MP0003077_abnormal_cell_cycle1.40210647
33MP0000537_abnormal_urethra_morphology1.36879389
34MP0002138_abnormal_hepatobiliary_system1.34256650
35MP0009379_abnormal_foot_pigmentation1.31871354
36MP0003890_abnormal_embryonic-extraembry1.27791705
37MP0004957_abnormal_blastocyst_morpholog1.27468746
38MP0001119_abnormal_female_reproductive1.24580445
39MP0001984_abnormal_olfaction1.24350041
40MP0002234_abnormal_pharynx_morphology1.23250534
41MP0001730_embryonic_growth_arrest1.22518379
42MP0003950_abnormal_plasma_membrane1.21644953
43MP0003942_abnormal_urinary_system1.16966943
44MP0005360_urolithiasis1.14445592
45MP0005275_abnormal_skin_tensile1.14318096
46MP0008932_abnormal_embryonic_tissue1.12930582
47MP0003941_abnormal_skin_development1.11694602
48MP0009703_decreased_birth_body1.09544919
49MP0003136_yellow_coat_color1.06802177
50MP0000631_abnormal_neuroendocrine_gland1.05580342
51MP0010234_abnormal_vibrissa_follicle1.05305533
52MP0008789_abnormal_olfactory_epithelium1.04911906
53MP0003385_abnormal_body_wall1.03607779
54MP0003279_aneurysm1.01834616
55MP0003878_abnormal_ear_physiology1.01567015
56MP0005377_hearing/vestibular/ear_phenot1.01567015
57MP0004197_abnormal_fetal_growth/weight/1.00894551
58MP0006276_abnormal_autonomic_nervous1.00883202
59MP0002233_abnormal_nose_morphology1.00643190
60MP0005647_abnormal_sex_gland0.97752075
61MP0003011_delayed_dark_adaptation0.96726327
62MP0001293_anophthalmia0.95096474
63MP0010678_abnormal_skin_adnexa0.94963421
64MP0002084_abnormal_developmental_patter0.93395501
65MP0002085_abnormal_embryonic_tissue0.93126677
66MP0009672_abnormal_birth_weight0.92580147
67MP0000534_abnormal_ureter_morphology0.91800357
68MP0003122_maternal_imprinting0.88079670
69MP0005171_absent_coat_pigmentation0.87862996
70MP0001666_abnormal_nutrient_absorption0.86288301
71MP0000049_abnormal_middle_ear0.85036869
72MP0003937_abnormal_limbs/digits/tail_de0.84111162
73MP0000383_abnormal_hair_follicle0.83332136
74MP0005389_reproductive_system_phenotype0.82012683
75MP0004808_abnormal_hematopoietic_stem0.81885309
76MP0005394_taste/olfaction_phenotype0.81649897
77MP0005499_abnormal_olfactory_system0.81649897
78MP0004134_abnormal_chest_morphology0.80941706
79MP0003787_abnormal_imprinting0.80279092
80MP0004272_abnormal_basement_membrane0.79642585
81MP0003119_abnormal_digestive_system0.79143873
82MP0005551_abnormal_eye_electrophysiolog0.78890981
83MP0002249_abnormal_larynx_morphology0.78832260
84MP0005380_embryogenesis_phenotype0.78774021
85MP0001672_abnormal_embryogenesis/_devel0.78774021
86MP0010030_abnormal_orbit_morphology0.78746018
87MP0002102_abnormal_ear_morphology0.78714562
88MP0003705_abnormal_hypodermis_morpholog0.77701602
89MP0003699_abnormal_female_reproductive0.77109735
90MP0006054_spinal_hemorrhage0.75240305
91MP0003936_abnormal_reproductive_system0.75014992
92MP0001697_abnormal_embryo_size0.74845346
93MP0003879_abnormal_hair_cell0.74245999
94MP0003315_abnormal_perineum_morphology0.74054826
95MP0002108_abnormal_muscle_morphology0.73889723
96MP0000428_abnormal_craniofacial_morphol0.73688876
97MP0003984_embryonic_growth_retardation0.72334276
98MP0005508_abnormal_skeleton_morphology0.71895594
99MP0002088_abnormal_embryonic_growth/wei0.71531051
100MP0010307_abnormal_tumor_latency0.71142028
101MP0000762_abnormal_tongue_morphology0.70429464
102MP0009053_abnormal_anal_canal0.69945448
103MP0000516_abnormal_urinary_system0.68852225
104MP0005367_renal/urinary_system_phenotyp0.68852225
105MP0000566_synostosis0.68765100
106MP0000350_abnormal_cell_proliferation0.68248081
107MP0002938_white_spotting0.66094478
108MP0001324_abnormal_eye_pigmentation0.65862400
109MP0003861_abnormal_nervous_system0.65596970
110MP0002697_abnormal_eye_size0.65077075
111MP0010352_gastrointestinal_tract_polyps0.63313954
112MP0002080_prenatal_lethality0.62344551
113MP0001986_abnormal_taste_sensitivity0.62159478
114MP0000432_abnormal_head_morphology0.60949075
115MP0001664_abnormal_digestion0.59920962
116MP0005174_abnormal_tail_pigmentation0.59893536
117MP0005646_abnormal_pituitary_gland0.59254888
118MP0001502_abnormal_circadian_rhythm0.58932079
119MP0002796_impaired_skin_barrier0.58430752
120MP0002932_abnormal_joint_morphology0.58051999
121MP0002114_abnormal_axial_skeleton0.57653910
122MP0005391_vision/eye_phenotype0.57431677
123MP0002092_abnormal_eye_morphology0.57180887
124MP0001188_hyperpigmentation0.56745031
125MP0003935_abnormal_craniofacial_develop0.55992918
126MP0002086_abnormal_extraembryonic_tissu0.55861318
127MP0001915_intracranial_hemorrhage0.55604502
128MP0006138_congestive_heart_failure0.55427969
129MP0003693_abnormal_embryo_hatching0.54795950
130MP0002272_abnormal_nervous_system0.54520452
131MP0002111_abnormal_tail_morphology0.54326508
132MP0005670_abnormal_white_adipose0.53022810
133MP0000427_abnormal_hair_cycle0.52956526
134MP0000313_abnormal_cell_death0.52801729
135MP0004142_abnormal_muscle_tone0.52181056
136MP0002751_abnormal_autonomic_nervous0.48387615
137MP0002127_abnormal_cardiovascular_syste0.47778825
138MP0000015_abnormal_ear_pigmentation0.47509906
139MP0000647_abnormal_sebaceous_gland0.47396427
140MP0001286_abnormal_eye_development0.47373039
141MP0003567_abnormal_fetal_cardiomyocyte0.45443744
142MP0000778_abnormal_nervous_system0.44546544
143MP0008004_abnormal_stomach_pH0.44443981
144MP0008260_abnormal_autophagy0.43535606
145MP0003283_abnormal_digestive_organ0.42310460
146MP0003959_abnormal_lean_body0.41862977
147MP0003868_abnormal_feces_composition0.40818535

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.20889848
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.82866290
3Absent/shortened dynein arms (HP:0200106)7.82866290
4Abnormal respiratory motile cilium physiology (HP:0012261)5.59384872
5Abnormal respiratory motile cilium morphology (HP:0005938)5.36471625
6Abnormal respiratory epithelium morphology (HP:0012253)5.36471625
7Oligodactyly (hands) (HP:0001180)5.20738711
8Gonadotropin excess (HP:0000837)5.08218284
9Azoospermia (HP:0000027)5.00664434
10Abnormal spermatogenesis (HP:0008669)4.82721388
11Abnormality of the lower motor neuron (HP:0002366)4.65748764
12Rhinitis (HP:0012384)4.60838484
13Chromsome breakage (HP:0040012)4.38396073
14Abnormal ciliary motility (HP:0012262)4.38383301
15Facial hemangioma (HP:0000329)4.21598137
16Chromosomal breakage induced by crosslinking agents (HP:0003221)4.17801961
17Infertility (HP:0000789)4.14034121
18Bell-shaped thorax (HP:0001591)4.08270016
19Chronic bronchitis (HP:0004469)4.04029036
20Osteomalacia (HP:0002749)4.00367988
21Fibular hypoplasia (HP:0003038)3.80213100
22Abnormality of abdominal situs (HP:0011620)3.77566663
23Abdominal situs inversus (HP:0003363)3.77566663
24Premature ovarian failure (HP:0008209)3.71830259
25Nephronophthisis (HP:0000090)3.69378839
26Oligodactyly (HP:0012165)3.61004864
27Lip pit (HP:0100267)3.52427381
28Volvulus (HP:0002580)3.51484240
29Aplasia/Hypoplasia of the tibia (HP:0005772)3.35950654
30Septo-optic dysplasia (HP:0100842)3.24298994
31Medial flaring of the eyebrow (HP:0010747)2.98045470
3211 pairs of ribs (HP:0000878)2.97439530
33Degeneration of anterior horn cells (HP:0002398)2.93007354
34Abnormality of the anterior horn cell (HP:0006802)2.93007354
35Absent septum pellucidum (HP:0001331)2.92627487
36Supernumerary spleens (HP:0009799)2.85566751
37Small intestinal stenosis (HP:0012848)2.85018058
38Duodenal stenosis (HP:0100867)2.85018058
39Capillary hemangiomas (HP:0005306)2.84544439
40Amyotrophic lateral sclerosis (HP:0007354)2.82103753
41Clitoromegaly (HP:0000057)2.82090285
42Selective tooth agenesis (HP:0001592)2.81547198
43Nasal polyposis (HP:0100582)2.78493851
44Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78184257
45Tubulointerstitial nephritis (HP:0001970)2.75383701
46Abnormality of chromosome stability (HP:0003220)2.71556069
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.67307500
48Abnormality of the renal medulla (HP:0100957)2.65420718
49Impulsivity (HP:0100710)2.64257835
50Abnormality of the septum pellucidum (HP:0007375)2.63998416
51Facial cleft (HP:0002006)2.63452328
52Male infertility (HP:0003251)2.63022982
53Wrist flexion contracture (HP:0001239)2.58641420
54Maternal diabetes (HP:0009800)2.58550022
55Absent radius (HP:0003974)2.55767518
56Congenital primary aphakia (HP:0007707)2.54202646
57Shoulder girdle muscle weakness (HP:0003547)2.52135527
58Gait imbalance (HP:0002141)2.51718877
59Heterotopia (HP:0002282)2.49131677
60Abnormality of dentin (HP:0010299)2.47986894
61Upper motor neuron abnormality (HP:0002127)2.47736618
62Poor coordination (HP:0002370)2.47007075
63Anterior segment dysgenesis (HP:0007700)2.46802466
64Meckel diverticulum (HP:0002245)2.45371587
65Missing ribs (HP:0000921)2.44459366
66Hypophosphatemic rickets (HP:0004912)2.44334132
67Aplasia involving forearm bones (HP:0009822)2.40989081
68Absent forearm bone (HP:0003953)2.40989081
69Abnormality of the duodenum (HP:0002246)2.40023623
70Bronchiectasis (HP:0002110)2.37498592
71Fair hair (HP:0002286)2.36922260
72Abnormality of the preputium (HP:0100587)2.36760815
73Abnormality of the ileum (HP:0001549)2.35820259
74Enlarged penis (HP:0000040)2.35726958
75Genital tract atresia (HP:0001827)2.34879569
76Abnormality of DNA repair (HP:0003254)2.34053934
77Aplasia/Hypoplasia of the fibula (HP:0006492)2.29677443
78Turricephaly (HP:0000262)2.29106734
79Vaginal atresia (HP:0000148)2.28306265
80Horizontal nystagmus (HP:0000666)2.28299515
81Rhabdomyosarcoma (HP:0002859)2.25489528
82Papillary thyroid carcinoma (HP:0002895)2.23495024
83Tubular atrophy (HP:0000092)2.22698312
84Hand muscle atrophy (HP:0009130)2.22264410
85Hypoplasia of the fovea (HP:0007750)2.21683162
86Aplasia/Hypoplasia of the fovea (HP:0008060)2.21683162
87Embryonal renal neoplasm (HP:0011794)2.21232916
88Bronchitis (HP:0012387)2.20424474
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20320352
90Degeneration of the lateral corticospinal tracts (HP:0002314)2.20320352
91Abnormality of the clitoris (HP:0000056)2.19584531
92Postaxial foot polydactyly (HP:0001830)2.18831088
93Tubulointerstitial abnormality (HP:0001969)2.17592647
94Abnormality of the nasal mucosa (HP:0000433)2.17207610
95Breech presentation (HP:0001623)2.17133608
96Nephroblastoma (Wilms tumor) (HP:0002667)2.16690016
97Optic nerve hypoplasia (HP:0000609)2.15626850
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.14807987
99Nephrogenic diabetes insipidus (HP:0009806)2.14208278
100Truncal obesity (HP:0001956)2.13105741
101Molar tooth sign on MRI (HP:0002419)2.12391576
102Abnormality of midbrain morphology (HP:0002418)2.12391576
103Short ribs (HP:0000773)2.07636100
104Horseshoe kidney (HP:0000085)2.06348409
105Abnormality of the labia (HP:0000058)2.04117801
106Increased nuchal translucency (HP:0010880)2.03533067
107Abnormality of the renal cortex (HP:0011035)2.03254564
108Microglossia (HP:0000171)2.03213585
109Dental crowding (HP:0000678)2.01472927
110Abnormality of the fovea (HP:0000493)2.01393249
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01251206
112Preaxial hand polydactyly (HP:0001177)1.98565364
113Impaired proprioception (HP:0010831)1.98469666
114Stage 5 chronic kidney disease (HP:0003774)1.98386329
115Abnormal lung lobation (HP:0002101)1.97630537
116Bifid tongue (HP:0010297)1.95678348
117Scotoma (HP:0000575)1.95617596
118Abnormality of chromosome segregation (HP:0002916)1.93609880
119Sensory axonal neuropathy (HP:0003390)1.91668820
120Proximal tubulopathy (HP:0000114)1.90858516
121Midline defect of the nose (HP:0004122)1.89579511
122Bicornuate uterus (HP:0000813)1.89188634
123Agnosia (HP:0010524)1.88523875
124Postaxial hand polydactyly (HP:0001162)1.87988465
125Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.85179327
126Abnormality of the renal collecting system (HP:0004742)1.84017826
127Aplasia/Hypoplasia of the sternum (HP:0006714)1.83411022
128Triphalangeal thumb (HP:0001199)1.83212357
129Abnormal biliary tract physiology (HP:0012439)1.83211867
130Bile duct proliferation (HP:0001408)1.83211867
131Ankle contracture (HP:0006466)1.82992974
132Prolonged neonatal jaundice (HP:0006579)1.82924603
133Rimmed vacuoles (HP:0003805)1.82539972
134Abnormality of the labia minora (HP:0012880)1.80381426
135Male pseudohermaphroditism (HP:0000037)1.79975021
136Non-midline cleft lip (HP:0100335)1.79011777
137Absent thumb (HP:0009777)1.77574456
138Stillbirth (HP:0003826)1.77137981
139Adrenal hypoplasia (HP:0000835)1.76044943
140Aplasia/Hypoplasia of the lens (HP:0008063)1.75975690
141Short 4th metacarpal (HP:0010044)1.75776631
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.75776631
143Abnormality of the phalanges of the hallux (HP:0010057)1.75775593
144Atrophy/Degeneration involving motor neurons (HP:0007373)1.75309021
145Widely patent fontanelles and sutures (HP:0004492)1.74070173
146Abnormality of the corticospinal tract (HP:0002492)1.71301124
147Breast carcinoma (HP:0003002)1.70299737
148Short thumb (HP:0009778)1.69645507
149Median cleft lip (HP:0000161)1.69301662
150Abnormal gallbladder physiology (HP:0012438)1.69034071
151Cholecystitis (HP:0001082)1.69034071
152Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68889104
153Renal duplication (HP:0000075)1.68572591
154Renovascular hypertension (HP:0100817)1.68490826
155Chronic hepatic failure (HP:0100626)1.68021794
156Aplasia/Hypoplasia of the earlobes (HP:0009906)1.67462263
157Upper limb amyotrophy (HP:0009129)1.66371961
158Distal upper limb amyotrophy (HP:0007149)1.66371961
159Hypoplasia of the uterus (HP:0000013)1.66367377
160Clubbing of toes (HP:0100760)1.66002768
161Intrahepatic cholestasis (HP:0001406)1.65404254
162Abnormal auditory evoked potentials (HP:0006958)1.65266048
163Aplasia/Hypoplasia involving the musculature (HP:0001460)1.64844461
164Shawl scrotum (HP:0000049)1.62995281
165Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.62933984
166Renal cortical cysts (HP:0000803)1.62275795
167Thyroid carcinoma (HP:0002890)1.61215242
168Polycystic ovaries (HP:0000147)1.60705031
169Broad foot (HP:0001769)1.55223561
170Short thorax (HP:0010306)1.54813274
171Tubulointerstitial fibrosis (HP:0005576)1.54336031
172Short tibia (HP:0005736)1.52890803
173Rectovaginal fistula (HP:0000143)1.52874686
174Rectal fistula (HP:0100590)1.52874686
175Renal dysplasia (HP:0000110)1.52288516
176Abnormal delivery (HP:0001787)1.52123094
177Bladder diverticulum (HP:0000015)1.51248162
178Recurrent otitis media (HP:0000403)1.51162885
179Ectopic kidney (HP:0000086)1.49924653

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.64592350
2PDK46.64592350
3PDK24.30640842
4CDK194.14236438
5PNCK3.94088824
6MAP3K93.88941332
7CDC73.68230952
8ARAF3.52903583
9EIF2AK13.07319738
10MAP3K132.94104226
11CDK122.77039432
12TESK12.65484639
13ICK2.63007360
14BRAF2.59510845
15PRKD32.53867153
16NEK62.47606652
17NEK22.22854460
18ACVR1B2.17177274
19PTK2B1.86612544
20LMTK21.80374536
21WEE11.71631708
22ZAK1.70775552
23MST41.69316603
24TAOK31.69050347
25TRIM281.68791663
26TYRO31.67500877
27STK161.64454698
28RAF11.51678240
29OXSR11.48043980
30STK31.44335448
31TNIK1.43495072
32VRK11.37825670
33STK38L1.36997564
34SRPK11.34860982
35MOS1.34714696
36MKNK11.33784904
37STK391.33747283
38NUAK11.33246964
39EIF2AK21.30446013
40PASK1.29583022
41PRKCI1.26674445
42ATR1.24277992
43CAMK1G1.23652506
44MKNK21.22866485
45NEK91.22075487
46KSR21.21834582
47PLK11.19305313
48MAP2K31.13405662
49WNK41.08998955
50PLK41.04896648
51CHEK11.04736412
52MUSK1.04571517
53PLK31.02335868
54TTK1.01537149
55MAP2K40.93891971
56KSR10.89541495
57ATM0.86558552
58WNK10.85411438
59MAP2K60.81144659
60PDGFRA0.76466015
61BRSK20.76420312
62CHEK20.76362184
63CDK70.72109948
64TIE10.70475469
65CCNB10.69630249
66ERBB40.66250246
67MELK0.66211998
68TGFBR10.65782166
69WNK30.63811136
70BMPR1B0.63595616
71MAP3K80.62308759
72MAP3K40.62099252
73PBK0.61355818
74BCR0.60880559
75IRAK20.59692030
76DYRK30.58720994
77CSNK1G10.58217534
78PAK40.57597930
79MET0.55900126
80PINK10.55407489
81BUB10.54800266
82CSF1R0.53463124
83CDK80.53387985
84PRKG10.53143184
85LATS10.52876736
86CSNK1E0.52568582
87CDK10.52357175
88CDK20.51490901
89PLK20.51381069
90PIM10.51036728
91TSSK60.50915471
92STK240.48897647
93MTOR0.48830397
94DMPK0.48196163
95BRD40.46844030
96NTRK30.46382787
97DYRK1B0.45856030
98PAK30.45429510
99NLK0.44332472
100PKN10.44296289
101PDGFRB0.42194707
102AURKB0.41720469
103PAK10.41531383
104IRAK10.41166750
105LATS20.41078863
106FGFR20.39178112
107CDK30.37083219
108EIF2AK30.36859726
109PRKDC0.35540264
110DDR20.35193078
111EGFR0.34225923
112PTK20.33479367
113STK380.30794022
114CLK10.30417723
115DYRK1A0.30298540
116MARK30.28442724
117TNK20.27828046
118PIK3CG0.27653063
119MAPK10.27621447
120GSK3B0.27343491
121SIK30.27284785
122INSRR0.27283709
123CSNK1D0.26942971
124CDK40.25613421
125PAK20.25388500
126RPS6KB10.23751597
127CSNK2A10.23433187
128MAPK140.23168263
129PTK60.22864520
130NTRK20.20793406
131EPHB20.19864857
132PRKACB0.19569911
133LIMK10.19513763
134CSNK2A20.19228262
135CDK60.18536048
136MAPK80.18333089
137AKT10.18277058
138NEK10.17955769
139SCYL20.17551632
140CDK90.17262552
141BRSK10.17180875
142AURKA0.16394900
143PHKG20.16114015
144PHKG10.16114015
145TLK10.16057089

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.82374084
2Homologous recombination_Homo sapiens_hsa034403.54469043
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.47784668
4Mismatch repair_Homo sapiens_hsa034303.31555814
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.14617436
6RNA transport_Homo sapiens_hsa030133.12131104
7Fanconi anemia pathway_Homo sapiens_hsa034602.83135333
8Nucleotide excision repair_Homo sapiens_hsa034202.75749807
9mRNA surveillance pathway_Homo sapiens_hsa030152.75603025
10DNA replication_Homo sapiens_hsa030302.74186638
11Dorso-ventral axis formation_Homo sapiens_hsa043202.61516771
12Cell cycle_Homo sapiens_hsa041102.60869239
13Selenocompound metabolism_Homo sapiens_hsa004502.49248516
14Oocyte meiosis_Homo sapiens_hsa041142.47774386
15Pyruvate metabolism_Homo sapiens_hsa006202.13159320
16Propanoate metabolism_Homo sapiens_hsa006402.10073481
17Spliceosome_Homo sapiens_hsa030402.04436235
18Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.87893184
19Proteasome_Homo sapiens_hsa030501.65883557
20Caffeine metabolism_Homo sapiens_hsa002321.60526638
21Ovarian steroidogenesis_Homo sapiens_hsa049131.58091150
22Basal cell carcinoma_Homo sapiens_hsa052171.57698259
23RNA degradation_Homo sapiens_hsa030181.50962389
24Base excision repair_Homo sapiens_hsa034101.49610043
25Circadian rhythm_Homo sapiens_hsa047101.46648921
26Fatty acid biosynthesis_Homo sapiens_hsa000611.43445811
27Hedgehog signaling pathway_Homo sapiens_hsa043401.42065560
28Regulation of autophagy_Homo sapiens_hsa041401.40454635
29Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38620274
30Non-homologous end-joining_Homo sapiens_hsa034501.34712669
31p53 signaling pathway_Homo sapiens_hsa041151.33947962
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33540063
33One carbon pool by folate_Homo sapiens_hsa006701.32881446
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.28830319
35Phototransduction_Homo sapiens_hsa047441.25691219
36Olfactory transduction_Homo sapiens_hsa047401.25605991
37Vitamin B6 metabolism_Homo sapiens_hsa007501.15292855
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14792565
39TGF-beta signaling pathway_Homo sapiens_hsa043501.11828068
40Glucagon signaling pathway_Homo sapiens_hsa049221.10380486
41Hippo signaling pathway_Homo sapiens_hsa043901.07716260
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.06752966
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.00585241
44Maturity onset diabetes of the young_Homo sapiens_hsa049500.99643550
45Folate biosynthesis_Homo sapiens_hsa007900.96713715
46Pyrimidine metabolism_Homo sapiens_hsa002400.94350832
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92597644
48Glycerolipid metabolism_Homo sapiens_hsa005610.92401806
49Pentose phosphate pathway_Homo sapiens_hsa000300.91580902
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91289639
51Epstein-Barr virus infection_Homo sapiens_hsa051690.91068475
52Protein export_Homo sapiens_hsa030600.88981430
53Lysine degradation_Homo sapiens_hsa003100.87674605
54Purine metabolism_Homo sapiens_hsa002300.86007144
55N-Glycan biosynthesis_Homo sapiens_hsa005100.85492941
56Fatty acid metabolism_Homo sapiens_hsa012120.84603103
57Adherens junction_Homo sapiens_hsa045200.84202879
58Huntingtons disease_Homo sapiens_hsa050160.83421618
59HTLV-I infection_Homo sapiens_hsa051660.83356518
60Gap junction_Homo sapiens_hsa045400.81916542
61Small cell lung cancer_Homo sapiens_hsa052220.81661875
62RNA polymerase_Homo sapiens_hsa030200.81458432
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.80807098
64Wnt signaling pathway_Homo sapiens_hsa043100.75449524
65ECM-receptor interaction_Homo sapiens_hsa045120.75299389
66Herpes simplex infection_Homo sapiens_hsa051680.73942319
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72207318
68ABC transporters_Homo sapiens_hsa020100.71854791
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70870974
70Nicotine addiction_Homo sapiens_hsa050330.70718542
71Ribosome_Homo sapiens_hsa030100.69577235
72MicroRNAs in cancer_Homo sapiens_hsa052060.67613655
73Linoleic acid metabolism_Homo sapiens_hsa005910.65000453
74Steroid biosynthesis_Homo sapiens_hsa001000.63922301
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61984822
76Tight junction_Homo sapiens_hsa045300.61613506
77Influenza A_Homo sapiens_hsa051640.61591434
78Carbon metabolism_Homo sapiens_hsa012000.61405038
79Viral carcinogenesis_Homo sapiens_hsa052030.58195095
80Glutathione metabolism_Homo sapiens_hsa004800.58172384
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57606316
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55935299
83Prostate cancer_Homo sapiens_hsa052150.55123177
84Notch signaling pathway_Homo sapiens_hsa043300.54957376
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.53748973
86PPAR signaling pathway_Homo sapiens_hsa033200.52894489
87Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49300466
88Biosynthesis of amino acids_Homo sapiens_hsa012300.48676301
89Pathways in cancer_Homo sapiens_hsa052000.48005998
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45964703
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45823257
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45225189
93Legionellosis_Homo sapiens_hsa051340.44660341
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41479026
95Protein digestion and absorption_Homo sapiens_hsa049740.41308294
96Thyroid cancer_Homo sapiens_hsa052160.41060316
97Focal adhesion_Homo sapiens_hsa045100.40477194
98Inositol phosphate metabolism_Homo sapiens_hsa005620.40239235
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39120578
100Fat digestion and absorption_Homo sapiens_hsa049750.38197207
101Retinol metabolism_Homo sapiens_hsa008300.37432129
102Vitamin digestion and absorption_Homo sapiens_hsa049770.36198879
103Bile secretion_Homo sapiens_hsa049760.36152719
104Ether lipid metabolism_Homo sapiens_hsa005650.35310855
105Antigen processing and presentation_Homo sapiens_hsa046120.34818471
106mTOR signaling pathway_Homo sapiens_hsa041500.34803843
107Renin secretion_Homo sapiens_hsa049240.34573623
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34412006
109Salmonella infection_Homo sapiens_hsa051320.34033657
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.33969277
111Axon guidance_Homo sapiens_hsa043600.33171733
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32562223
113Serotonergic synapse_Homo sapiens_hsa047260.29958303
114Proteoglycans in cancer_Homo sapiens_hsa052050.28523167
115Taste transduction_Homo sapiens_hsa047420.26659777
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26566209
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26487815
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26152048
119beta-Alanine metabolism_Homo sapiens_hsa004100.24467655
120VEGF signaling pathway_Homo sapiens_hsa043700.24452222
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.23899789
122Fatty acid elongation_Homo sapiens_hsa000620.23488433
123Melanogenesis_Homo sapiens_hsa049160.23061275
124Toxoplasmosis_Homo sapiens_hsa051450.22750327
125Long-term depression_Homo sapiens_hsa047300.19775015
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19513133
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19469351
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.18642445
129AMPK signaling pathway_Homo sapiens_hsa041520.18029336
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17907455
131Metabolic pathways_Homo sapiens_hsa011000.17180807
132Primary bile acid biosynthesis_Homo sapiens_hsa001200.16424549
133Calcium signaling pathway_Homo sapiens_hsa040200.15934627
134Cardiac muscle contraction_Homo sapiens_hsa042600.13473252
135Colorectal cancer_Homo sapiens_hsa052100.13286429
136Estrogen signaling pathway_Homo sapiens_hsa049150.12506676
137Arginine and proline metabolism_Homo sapiens_hsa003300.11809070
138Morphine addiction_Homo sapiens_hsa050320.11773551
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.11204906
140Parkinsons disease_Homo sapiens_hsa050120.10190981
141Synaptic vesicle cycle_Homo sapiens_hsa047210.09302188
142FoxO signaling pathway_Homo sapiens_hsa040680.09083409
143ErbB signaling pathway_Homo sapiens_hsa040120.08844533

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