RBM44

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.01936335
2male meiosis (GO:0007140)8.71547580
3synaptonemal complex assembly (GO:0007130)8.56081681
4synaptonemal complex organization (GO:0070193)8.33151491
5DNA methylation involved in gamete generation (GO:0043046)7.76926830
6fusion of sperm to egg plasma membrane (GO:0007342)7.23029465
7sperm-egg recognition (GO:0035036)6.80347570
8acrosome assembly (GO:0001675)6.61770016
9binding of sperm to zona pellucida (GO:0007339)6.54770270
10chromosome organization involved in meiosis (GO:0070192)6.52206733
11multicellular organism reproduction (GO:0032504)6.48707903
12sperm motility (GO:0030317)6.32344565
13meiotic nuclear division (GO:0007126)6.23795768
14cell-cell recognition (GO:0009988)6.15749511
15male meiosis I (GO:0007141)6.11869435
16axonemal dynein complex assembly (GO:0070286)6.00321529
17regulation of meiosis I (GO:0060631)5.74756047
18spermatid development (GO:0007286)5.64163395
19plasma membrane fusion (GO:0045026)5.33321879
20epithelial cilium movement (GO:0003351)5.27412474
21meiosis I (GO:0007127)5.26768215
22nuclear pore complex assembly (GO:0051292)5.20772943
23reproduction (GO:0000003)5.12809651
24cell wall macromolecule catabolic process (GO:0016998)4.83241268
25cell wall macromolecule metabolic process (GO:0044036)4.83241268
26nuclear pore organization (GO:0006999)4.81171559
27gene silencing by RNA (GO:0031047)4.80962910
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.78186319
29motile cilium assembly (GO:0044458)4.74982405
30cilium movement (GO:0003341)4.74605465
31meiotic cell cycle process (GO:1903046)4.73814754
32meiotic chromosome segregation (GO:0045132)4.72547174
33meiotic cell cycle (GO:0051321)4.64697090
34acrosome reaction (GO:0007340)4.60356746
35microtubule depolymerization (GO:0007019)4.47421017
36regulation of cilium movement (GO:0003352)4.36833608
37single fertilization (GO:0007338)4.24590435
38fertilization (GO:0009566)4.19176394
39monoubiquitinated protein deubiquitination (GO:0035520)4.14596490
40DNA replication-dependent nucleosome organization (GO:0034723)4.13985302
41DNA replication-dependent nucleosome assembly (GO:0006335)4.13985302
42germ cell development (GO:0007281)4.10475835
43synapsis (GO:0007129)4.09850335
44mitotic sister chromatid cohesion (GO:0007064)4.07111392
45regulation of centriole replication (GO:0046599)4.06856147
46spermatogenesis (GO:0007283)4.03844755
47male gamete generation (GO:0048232)4.03633079
48pore complex assembly (GO:0046931)4.01824720
49DNA alkylation (GO:0006305)4.00879338
50DNA methylation (GO:0006306)4.00879338
51attachment of spindle microtubules to kinetochore (GO:0008608)3.99898750
52histone exchange (GO:0043486)3.98431159
53sister chromatid cohesion (GO:0007062)3.95348178
54DNA deamination (GO:0045006)3.86187308
55protein localization to chromosome, centromeric region (GO:0071459)3.84139441
56gamete generation (GO:0007276)3.80981464
57cellular process involved in reproduction in multicellular organism (GO:0022412)3.79267487
58mitotic chromosome condensation (GO:0007076)3.79235098
59establishment of protein localization to Golgi (GO:0072600)3.78693185
60detection of light stimulus involved in visual perception (GO:0050908)3.76382820
61detection of light stimulus involved in sensory perception (GO:0050962)3.76382820
62protein K6-linked ubiquitination (GO:0085020)3.74969647
63L-fucose catabolic process (GO:0042355)3.68950746
64fucose catabolic process (GO:0019317)3.68950746
65L-fucose metabolic process (GO:0042354)3.68950746
66reciprocal meiotic recombination (GO:0007131)3.66732128
67reciprocal DNA recombination (GO:0035825)3.66732128
68regulation of histone H3-K9 methylation (GO:0051570)3.65216703
69axoneme assembly (GO:0035082)3.62417247
70protein targeting to Golgi (GO:0000042)3.60139186
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59737432
72gene silencing (GO:0016458)3.59316359
73centriole replication (GO:0007099)3.56318451
74protein K11-linked deubiquitination (GO:0035871)3.56206000
75mitotic sister chromatid segregation (GO:0000070)3.55365850
76neural tube formation (GO:0001841)3.54378208
77oogenesis (GO:0048477)3.52730184
78protein localization to kinetochore (GO:0034501)3.47424347
79sperm capacitation (GO:0048240)3.47399325
80kinetochore organization (GO:0051383)3.46868712
81adaptation of signaling pathway (GO:0023058)3.45099681
82cellular ketone body metabolic process (GO:0046950)3.44866911
83mitotic nuclear envelope disassembly (GO:0007077)3.42295517
84DNA packaging (GO:0006323)3.42152043
85chromosome condensation (GO:0030261)3.40149969
86mitotic metaphase plate congression (GO:0007080)3.37428386
87regulation of chromosome segregation (GO:0051983)3.36684283
88regulation of hexokinase activity (GO:1903299)3.35398688
89regulation of glucokinase activity (GO:0033131)3.35398688
90chromatin remodeling at centromere (GO:0031055)3.33502212
91negative regulation of meiosis (GO:0045835)3.30022291
92resolution of meiotic recombination intermediates (GO:0000712)3.29855974
93heterochromatin organization (GO:0070828)3.28589019
94regulation of centrosome cycle (GO:0046605)3.28205531
95regulation of spindle checkpoint (GO:0090231)3.27465593
96metaphase plate congression (GO:0051310)3.26715517
97DNA methylation or demethylation (GO:0044728)3.23473986
98indolalkylamine metabolic process (GO:0006586)3.22140418
99chromosome organization (GO:0051276)3.22066348
100membrane disassembly (GO:0030397)3.20727166
101nuclear envelope disassembly (GO:0051081)3.20727166
102microtubule severing (GO:0051013)3.19581108
103ketone body metabolic process (GO:1902224)3.19508841
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.17063517
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.17063517
106positive regulation of mitotic sister chromatid separation (GO:1901970)3.17063517
107RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.14970242
108retrograde transport, vesicle recycling within Golgi (GO:0000301)3.14904392
109negative regulation of cAMP-mediated signaling (GO:0043951)3.14107017
110DNA replication checkpoint (GO:0000076)3.13399204
111sister chromatid segregation (GO:0000819)3.12122761
112seminiferous tubule development (GO:0072520)3.12071826
113DNA replication-independent nucleosome organization (GO:0034724)3.11344140
114DNA replication-independent nucleosome assembly (GO:0006336)3.11344140
115regulation of acrosome reaction (GO:0060046)3.11015502
116chaperone-mediated protein complex assembly (GO:0051131)3.09373094
117protein polyglutamylation (GO:0018095)3.09343908
118female gamete generation (GO:0007292)3.08512120
119DNA synthesis involved in DNA repair (GO:0000731)3.05736699
120translesion synthesis (GO:0019985)3.05472000
121tryptophan catabolic process (GO:0006569)3.05131585
122indole-containing compound catabolic process (GO:0042436)3.05131585
123indolalkylamine catabolic process (GO:0046218)3.05131585
124negative regulation of chromosome segregation (GO:0051985)3.04417200
125ventricular system development (GO:0021591)3.03534756
126protein localization to Golgi apparatus (GO:0034067)2.97853907
127response to pheromone (GO:0019236)2.93011679
128phosphatidylethanolamine metabolic process (GO:0046337)2.91116220
129retinal cone cell development (GO:0046549)2.88813393
130protein prenylation (GO:0018342)2.88545182
131prenylation (GO:0097354)2.88545182
132regulation of B cell receptor signaling pathway (GO:0050855)2.82495555
133interferon-gamma production (GO:0032609)2.82084922
134respiratory chain complex IV assembly (GO:0008535)2.73021105
135positive regulation of meiosis (GO:0045836)2.71027140
136regulation of female gonad development (GO:2000194)2.69323081
137tryptophan metabolic process (GO:0006568)2.65906533
138platelet dense granule organization (GO:0060155)2.61352232
139interkinetic nuclear migration (GO:0022027)2.57673175
140positive regulation of granulocyte differentiation (GO:0030854)2.56375864
141phosphatidylethanolamine biosynthetic process (GO:0006646)2.55232776
142histone mRNA catabolic process (GO:0071044)2.52282717
143mast cell activation (GO:0045576)2.51962846
144cytidine deamination (GO:0009972)2.50246091
145cytidine metabolic process (GO:0046087)2.50246091
146cytidine catabolic process (GO:0006216)2.50246091
147rRNA catabolic process (GO:0016075)2.48530527
148regulation of memory T cell differentiation (GO:0043380)2.48120979
149mast cell degranulation (GO:0043303)2.47716854
150mast cell activation involved in immune response (GO:0002279)2.47716854
151positive regulation of meiotic cell cycle (GO:0051446)2.47169258
152DNA double-strand break processing (GO:0000729)2.47031869
153single strand break repair (GO:0000012)2.47015889
154negative regulation of DNA-dependent DNA replication (GO:2000104)2.44301973
155negative regulation of mast cell activation (GO:0033004)2.42884387
156detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.42818594
157positive regulation of defense response to virus by host (GO:0002230)2.42614483
158cytochrome complex assembly (GO:0017004)2.41854502
159cellular response to interleukin-15 (GO:0071350)2.39697687
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.39323499
161positive regulation of interleukin-17 production (GO:0032740)2.37463549
162positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.36649997
163pyrimidine ribonucleoside catabolic process (GO:0046133)2.36390908
164photoreceptor cell maintenance (GO:0045494)2.35371092
165cAMP catabolic process (GO:0006198)2.35344092
166kynurenine metabolic process (GO:0070189)2.32778367
167cellular response to ethanol (GO:0071361)2.32141322
168microtubule nucleation (GO:0007020)2.32103073
169double-strand break repair via homologous recombination (GO:0000724)2.31997314
170piRNA metabolic process (GO:0034587)10.9383878

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.08771938
2E2F7_22180533_ChIP-Seq_HELA_Human7.74025035
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.83858422
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57236034
5ZNF274_21170338_ChIP-Seq_K562_Hela3.30230795
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28277679
7VDR_22108803_ChIP-Seq_LS180_Human2.85123553
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75994469
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63543935
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.60555450
11AR_21909140_ChIP-Seq_LNCAP_Human2.45164951
12GBX2_23144817_ChIP-Seq_PC3_Human2.42419830
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41502034
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.37856990
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.35150177
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28628898
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.27662131
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25081004
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23226688
20IGF1R_20145208_ChIP-Seq_DFB_Human2.22324168
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.19184205
22FUS_26573619_Chip-Seq_HEK293_Human2.13253225
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.05259532
24ER_23166858_ChIP-Seq_MCF-7_Human1.98633548
25P300_19829295_ChIP-Seq_ESCs_Human1.98335868
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.96014392
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94647712
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.87532346
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84893871
30TAF15_26573619_Chip-Seq_HEK293_Human1.80214226
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.78724128
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.75543075
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73366146
34GATA1_26923725_Chip-Seq_HPCs_Mouse1.72468770
35AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70177722
36CBP_20019798_ChIP-Seq_JUKART_Human1.68544107
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.68544107
38STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65962193
39MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65884420
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.64884895
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64756829
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62392985
43EWS_26573619_Chip-Seq_HEK293_Human1.62346777
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61197899
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60813058
46BCAT_22108803_ChIP-Seq_LS180_Human1.59194685
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.58760458
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58559391
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56339220
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55514334
51* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55313064
52STAT3_23295773_ChIP-Seq_U87_Human1.55109932
53SMAD4_21799915_ChIP-Seq_A2780_Human1.52672842
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52375059
55* EZH2_27294783_Chip-Seq_NPCs_Mouse1.51736540
56CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51373666
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50808816
58NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49796478
59NANOG_19829295_ChIP-Seq_ESCs_Human1.49535397
60SOX2_19829295_ChIP-Seq_ESCs_Human1.49535397
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.48485054
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48093101
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48000472
64CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47535815
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46465222
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.45863963
67TP53_22573176_ChIP-Seq_HFKS_Human1.45335295
68EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44160685
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.42949241
70VDR_23849224_ChIP-Seq_CD4+_Human1.42740524
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41995456
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41995456
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41176565
74TCF4_23295773_ChIP-Seq_U87_Human1.41015465
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.37746410
76IRF1_19129219_ChIP-ChIP_H3396_Human1.35660936
77* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35504195
78KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35048632
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.34431268
80AR_25329375_ChIP-Seq_VCAP_Human1.34421827
81GATA3_26560356_Chip-Seq_TH2_Human1.33290471
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31921399
83ETS1_20019798_ChIP-Seq_JURKAT_Human1.31097343
84TCF4_22108803_ChIP-Seq_LS180_Human1.30629246
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29915311
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.29672681
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29578760
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.29578760
89* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.27943420
90IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26335809
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26240951
92KDM5A_27292631_Chip-Seq_BREAST_Human1.25985766
93* CDX2_22108803_ChIP-Seq_LS180_Human1.25622917
94* CRX_20693478_ChIP-Seq_RETINA_Mouse1.24352069
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24082850
96XRN2_22483619_ChIP-Seq_HELA_Human1.23449200
97RUNX_20019798_ChIP-Seq_JUKART_Human1.23449120
98GABP_19822575_ChIP-Seq_HepG2_Human1.22832496
99FOXP3_21729870_ChIP-Seq_TREG_Human1.22722893
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.22450654
101GABP_17652178_ChIP-ChIP_JURKAT_Human1.21934430
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21289076
103SMAD_19615063_ChIP-ChIP_OVARY_Human1.20790271
104* NANOG_18555785_Chip-Seq_ESCs_Mouse1.20405006
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20364276
106RUNX2_22187159_ChIP-Seq_PCA_Human1.19248221
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18670741
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16633720
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.16573078
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16407936
111DCP1A_22483619_ChIP-Seq_HELA_Human1.14422755
112* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13211735
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11912339
114GATA3_21878914_ChIP-Seq_MCF-7_Human1.11764959
115AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11674007
116* E2F1_18555785_Chip-Seq_ESCs_Mouse1.11500319
117* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11242392
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10556748
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09621304
120GATA3_26560356_Chip-Seq_TH1_Human1.08778248
121TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.07289548
122AR_20517297_ChIP-Seq_VCAP_Human1.07250990
123* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07095602
124FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06194522
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06069274
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05841764
127* P53_22387025_ChIP-Seq_ESCs_Mouse1.04822625
128OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04243121
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04168893
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04156721
131ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03579953
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02911115
133PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02740944
134* STAT3_18555785_Chip-Seq_ESCs_Mouse1.02454063
135SMRT_27268052_Chip-Seq_Bcells_Human1.02010468
136YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00840892
137RUNX1_26923725_Chip-Seq_HPCs_Mouse0.99955275
138TTF2_22483619_ChIP-Seq_HELA_Human0.98973369
139EZH2_22144423_ChIP-Seq_EOC_Human0.98141646
140EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.97373603
141ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97040994
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95358471
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95108863
144HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.93829986
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93762905
146ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92909356
147CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91077567
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89242714
149* NFE2_27457419_Chip-Seq_LIVER_Mouse0.87706653
150YY1_21170310_ChIP-Seq_MESCs_Mouse0.86708835
151* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86066877
152GATA3_21867929_ChIP-Seq_TH1_Mouse0.85451483
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84782456
154FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84558195
155GATA3_21867929_ChIP-Seq_CD8_Mouse0.84241365
156STAT1_17558387_ChIP-Seq_HELA_Human0.81480220
157SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.80100441
158RNF2_27304074_Chip-Seq_NSC_Mouse0.79681368
159DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79652432
160HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79191368
161MYC_18940864_ChIP-ChIP_HL60_Human0.78956842
162E2F1_18555785_ChIP-Seq_MESCs_Mouse0.74876300
163SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74451382
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74071414
165WDR5_24793694_ChIP-Seq_LNCAP_Human0.73375242
166* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72003462
167GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.70956736
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.70655496
169RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.69979618
170* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69443879
171THAP11_20581084_ChIP-Seq_MESCs_Mouse0.68901808
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.68283865
173CIITA_25753668_ChIP-Seq_RAJI_Human0.68276731
174TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.67836862
175SOX2_22085726_ChIP-Seq_NPCs_Mouse0.67730379
176KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.66950623
177KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.66950623
178KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.66950623
179CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.65443856
180* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64900450
181SPI1_26923725_Chip-Seq_HPCs_Mouse0.64759701
182RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.64296340
183TP63_19390658_ChIP-ChIP_HaCaT_Human0.63853394
184YY1_22570637_ChIP-Seq_MALME-3M_Human0.62970066
185SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.62690375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.56020180
2MP0008877_abnormal_DNA_methylation7.43236174
3MP0008057_abnormal_DNA_replication4.71157912
4MP0001929_abnormal_gametogenesis4.59657625
5MP0010094_abnormal_chromosome_stability4.44414132
6MP0003698_abnormal_male_reproductive4.13580059
7MP0002210_abnormal_sex_determination4.08375241
8MP0008058_abnormal_DNA_repair3.69750836
9MP0003693_abnormal_embryo_hatching3.63566841
10MP0003111_abnormal_nucleus_morphology3.52627009
11MP0001145_abnormal_male_reproductive3.38579302
12MP0000653_abnormal_sex_gland3.07653169
13MP0003077_abnormal_cell_cycle2.98561127
14MP0004957_abnormal_blastocyst_morpholog2.81251121
15MP0001986_abnormal_taste_sensitivity2.66781493
16MP0002653_abnormal_ependyma_morphology2.62439875
17MP0003786_premature_aging2.50207317
18MP0002161_abnormal_fertility/fecundity2.47556705
19MP0008995_early_reproductive_senescence2.42830650
20MP0008007_abnormal_cellular_replicative2.28597003
21MP0001835_abnormal_antigen_presentation2.25695200
22MP0002876_abnormal_thyroid_physiology2.09205002
23MP0005671_abnormal_response_to1.99192291
24MP0000372_irregular_coat_pigmentation1.97647988
25MP0005645_abnormal_hypothalamus_physiol1.97427525
26MP0002138_abnormal_hepatobiliary_system1.96034617
27MP0005075_abnormal_melanosome_morpholog1.92127378
28MP0005551_abnormal_eye_electrophysiolog1.91321855
29MP0010307_abnormal_tumor_latency1.87778372
30MP0001730_embryonic_growth_arrest1.85961390
31MP0000383_abnormal_hair_follicle1.85220920
32MP0003195_calcinosis1.83019347
33MP0002160_abnormal_reproductive_system1.82351634
34MP0005174_abnormal_tail_pigmentation1.79104409
35MP0000015_abnormal_ear_pigmentation1.66918552
36MP0003724_increased_susceptibility_to1.65740222
37MP0008932_abnormal_embryonic_tissue1.59815277
38MP0005310_abnormal_salivary_gland1.58526665
39MP0000350_abnormal_cell_proliferation1.51198392
40MP0001119_abnormal_female_reproductive1.46331394
41MP0003123_paternal_imprinting1.46111269
42MP0004381_abnormal_hair_follicle1.45713451
43MP0003718_maternal_effect1.45563047
44MP0002163_abnormal_gland_morphology1.44886673
45MP0001800_abnormal_humoral_immune1.42557302
46MP0002928_abnormal_bile_duct1.34901384
47MP0003252_abnormal_bile_duct1.34002195
48MP0008872_abnormal_physiological_respon1.33761699
49MP0005623_abnormal_meninges_morphology1.33502565
50MP0003646_muscle_fatigue1.33449100
51MP0006082_CNS_inflammation1.33339431
52MP0005380_embryogenesis_phenotype1.30922812
53MP0001672_abnormal_embryogenesis/_devel1.30922812
54MP0002254_reproductive_system_inflammat1.28829033
55MP0005379_endocrine/exocrine_gland_phen1.27891528
56MP0002693_abnormal_pancreas_physiology1.25742120
57MP0001873_stomach_inflammation1.23815669
58MP0004142_abnormal_muscle_tone1.23505039
59MP0001697_abnormal_embryo_size1.23108082
60MP0006292_abnormal_olfactory_placode1.22222061
61MP0002166_altered_tumor_susceptibility1.21151495
62MP0005389_reproductive_system_phenotype1.19957360
63MP0005647_abnormal_sex_gland1.19263415
64MP0003699_abnormal_female_reproductive1.18548234
65MP0004808_abnormal_hematopoietic_stem1.17493406
66MP0002084_abnormal_developmental_patter1.14240322
67MP0005253_abnormal_eye_physiology1.13790089
68MP0002085_abnormal_embryonic_tissue1.13697301
69MP0003984_embryonic_growth_retardation1.12311150
70MP0000313_abnormal_cell_death1.12271406
71MP0001501_abnormal_sleep_pattern1.11576240
72MP0002452_abnormal_antigen_presenting1.09233305
73MP0002723_abnormal_immune_serum1.09135383
74MP0003045_fibrosis1.09089663
75MP0010678_abnormal_skin_adnexa1.08243765
76MP0002088_abnormal_embryonic_growth/wei1.06989824
77MP0009785_altered_susceptibility_to1.05827181
78MP0002420_abnormal_adaptive_immunity1.05749296
79MP0005084_abnormal_gallbladder_morpholo1.05645882
80MP0003283_abnormal_digestive_organ1.04464507
81MP0004484_altered_response_of1.03378610
82MP0001819_abnormal_immune_cell1.02623684
83MP0002006_tumorigenesis1.02537083
84MP0002019_abnormal_tumor_incidence1.00262746
85MP0002080_prenatal_lethality1.00021353
86MP0005000_abnormal_immune_tolerance0.98832082
87MP0003890_abnormal_embryonic-extraembry0.98748118
88MP0000685_abnormal_immune_system0.97396393
89MP0002148_abnormal_hypersensitivity_rea0.95296284
90MP0001764_abnormal_homeostasis0.94227959
91MP0001968_abnormal_touch/_nociception0.94152301
92MP0005076_abnormal_cell_differentiation0.93744622
93MP0003121_genomic_imprinting0.93438757
94MP0009764_decreased_sensitivity_to0.91584142
95MP0002086_abnormal_extraembryonic_tissu0.90673044
96MP0004197_abnormal_fetal_growth/weight/0.90336192
97MP0010352_gastrointestinal_tract_polyps0.88395159
98MP0003787_abnormal_imprinting0.87143948
99MP0001486_abnormal_startle_reflex0.86785879
100MP0005387_immune_system_phenotype0.86180505
101MP0001790_abnormal_immune_system0.86180505
102MP0002419_abnormal_innate_immunity0.84731158
103MP0002837_dystrophic_cardiac_calcinosis0.84097067
104MP0005397_hematopoietic_system_phenotyp0.83269475
105MP0001545_abnormal_hematopoietic_system0.83269475
106MP0006072_abnormal_retinal_apoptosis0.82146289
107MP0002095_abnormal_skin_pigmentation0.81473604
108MP0002396_abnormal_hematopoietic_system0.80555717
109MP0009745_abnormal_behavioral_response0.78918128
110MP0000716_abnormal_immune_system0.77732304
111MP0010329_abnormal_lipoprotein_level0.77588057
112MP0002282_abnormal_trachea_morphology0.77296217
113MP0008875_abnormal_xenobiotic_pharmacok0.76872315
114MP0004133_heterotaxia0.75488556
115MP0005365_abnormal_bile_salt0.74911247
116MP0001293_anophthalmia0.74744258
117MP0002234_abnormal_pharynx_morphology0.74019514
118MP0005085_abnormal_gallbladder_physiolo0.73945919
119MP0006035_abnormal_mitochondrial_morpho0.73128945
120MP0002405_respiratory_system_inflammati0.72952747
121MP0001984_abnormal_olfaction0.72308542
122MP0003315_abnormal_perineum_morphology0.71523660
123MP0002102_abnormal_ear_morphology0.71506963
124MP0004233_abnormal_muscle_weight0.70885479
125MP0009672_abnormal_birth_weight0.69154737
126MP0000358_abnormal_cell_content/0.67569560
127MP0000569_abnormal_digit_pigmentation0.65951375
128MP0003763_abnormal_thymus_physiology0.64464710
129MP0000703_abnormal_thymus_morphology0.62159184
130MP0003878_abnormal_ear_physiology0.61086921
131MP0005377_hearing/vestibular/ear_phenot0.61086921
132MP0000427_abnormal_hair_cycle0.58102453
133MP0000490_abnormal_crypts_of0.57972118
134MP0001915_intracranial_hemorrhage0.56336406
135MP0003936_abnormal_reproductive_system0.56295502
136MP0005384_cellular_phenotype0.52847957
137MP0005621_abnormal_cell_physiology0.51951326
138MP0009278_abnormal_bone_marrow0.51739352
139MP0001727_abnormal_embryo_implantation0.51541635
140MP0003937_abnormal_limbs/digits/tail_de0.50236099
141MP0005395_other_phenotype0.49955852
142MP0009703_decreased_birth_body0.49147734
143MP0001919_abnormal_reproductive_system0.47447177
144MP0003950_abnormal_plasma_membrane0.45924666
145MP0003861_abnormal_nervous_system0.44835674
146MP0004264_abnormal_extraembryonic_tissu0.44044366
147MP0002398_abnormal_bone_marrow0.43975989
148MP0005670_abnormal_white_adipose0.43859262
149MP0000689_abnormal_spleen_morphology0.39184712
150MP0005451_abnormal_body_composition0.38621617
151MP0000432_abnormal_head_morphology0.37859769
152MP0002092_abnormal_eye_morphology0.37238607
153MP0002722_abnormal_immune_system0.34442440
154MP0002269_muscular_atrophy0.34284468
155MP0005266_abnormal_metabolism0.31686623
156MP0006036_abnormal_mitochondrial_physio0.30941598
157MP0003115_abnormal_respiratory_system0.28498924
158MP0003119_abnormal_digestive_system0.28042750
159MP0004134_abnormal_chest_morphology0.26556345
160MP0005391_vision/eye_phenotype0.25833346
161MP0002114_abnormal_axial_skeleton0.25744134
162MP0001661_extended_life_span0.25533985
163MP0002009_preneoplasia0.24580631
164MP0002429_abnormal_blood_cell0.24487238
165MP0002970_abnormal_white_adipose0.23621602
166MP0003943_abnormal_hepatobiliary_system0.23530692

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)8.25809892
2Absent/shortened dynein arms (HP:0200106)8.25809892
3Abnormal respiratory motile cilium physiology (HP:0012261)6.88933919
4Rhinitis (HP:0012384)5.98488657
5Abnormal respiratory epithelium morphology (HP:0012253)5.85452456
6Abnormal respiratory motile cilium morphology (HP:0005938)5.85452456
7Chronic bronchitis (HP:0004469)5.68042656
8Abnormal ciliary motility (HP:0012262)5.37135303
9Abnormal spermatogenesis (HP:0008669)4.91219219
10Infertility (HP:0000789)4.74697733
11Nasal polyposis (HP:0100582)4.74056325
12Azoospermia (HP:0000027)4.54490538
13Abnormality of the lower motor neuron (HP:0002366)4.28195372
14Attenuation of retinal blood vessels (HP:0007843)4.13574535
15Congenital stationary night blindness (HP:0007642)4.09981865
16Abnormal rod and cone electroretinograms (HP:0008323)3.95063309
17Pancreatic cysts (HP:0001737)3.92665567
18Intestinal atresia (HP:0011100)3.86619303
19Nephronophthisis (HP:0000090)3.81830911
20Bronchiectasis (HP:0002110)3.79897049
21Gonadotropin excess (HP:0000837)3.78388297
22Bronchitis (HP:0012387)3.76479936
23Abnormality of the nasal mucosa (HP:0000433)3.72292878
24Chromsome breakage (HP:0040012)3.62985265
25Male infertility (HP:0003251)3.47311486
26Chromosomal breakage induced by crosslinking agents (HP:0003221)3.44273280
27Impulsivity (HP:0100710)3.41772189
28Degeneration of anterior horn cells (HP:0002398)3.37362120
29Abnormality of the anterior horn cell (HP:0006802)3.37362120
30Severe visual impairment (HP:0001141)3.25318817
31Amyotrophic lateral sclerosis (HP:0007354)3.24937474
32Oligodactyly (hands) (HP:0001180)3.20970171
33Chronic hepatic failure (HP:0100626)3.19806731
3411 pairs of ribs (HP:0000878)3.04362469
35Supernumerary spleens (HP:0009799)3.02008619
36Abnormality of the renal medulla (HP:0100957)2.89396562
37Abnormality of chromosome stability (HP:0003220)2.88692684
38Selective tooth agenesis (HP:0001592)2.86716847
39Fibular hypoplasia (HP:0003038)2.85983673
40Abnormality of macular pigmentation (HP:0008002)2.84386398
41Recurrent otitis media (HP:0000403)2.77002203
42Progressive inability to walk (HP:0002505)2.76415024
43Upper motor neuron abnormality (HP:0002127)2.70402416
44Absent rod-and cone-mediated responses on ERG (HP:0007688)2.69592627
45True hermaphroditism (HP:0010459)2.68343681
46Stomatitis (HP:0010280)2.67376862
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.65750110
48Hypoplasia of the fovea (HP:0007750)2.65750110
49Bony spicule pigmentary retinopathy (HP:0007737)2.60378610
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.56327546
51Recurrent sinusitis (HP:0011108)2.54248839
52Ectopic kidney (HP:0000086)2.53593326
53Abnormality of midbrain morphology (HP:0002418)2.50437675
54Molar tooth sign on MRI (HP:0002419)2.50437675
55Abnormality of the preputium (HP:0100587)2.49849593
56Recurrent bronchitis (HP:0002837)2.48771456
57Meckel diverticulum (HP:0002245)2.47460989
58Constricted visual fields (HP:0001133)2.47235283
59Abolished electroretinogram (ERG) (HP:0000550)2.43167295
60Hypoplasia of the capital femoral epiphysis (HP:0003090)2.42686030
61Abnormality of the ileum (HP:0001549)2.36841717
62Sloping forehead (HP:0000340)2.34866233
63Hypothermia (HP:0002045)2.33730983
64Nephroblastoma (Wilms tumor) (HP:0002667)2.33650851
65Tubulointerstitial nephritis (HP:0001970)2.33640147
66Type II lissencephaly (HP:0007260)2.32266258
67Gaze-evoked nystagmus (HP:0000640)2.30707166
68Cystic liver disease (HP:0006706)2.29147885
69Widely spaced teeth (HP:0000687)2.28622932
70Albinism (HP:0001022)2.27304604
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.17795132
72Stomach cancer (HP:0012126)2.17642742
73Abnormality of the fovea (HP:0000493)2.17043846
74Heterotopia (HP:0002282)2.15110827
75Chronic diarrhea (HP:0002028)2.14548603
76Microglossia (HP:0000171)2.14009330
77Hyperalaninemia (HP:0003348)2.13554169
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13554169
79Abnormality of alanine metabolism (HP:0010916)2.13554169
80Embryonal renal neoplasm (HP:0011794)2.12909991
81Small intestinal stenosis (HP:0012848)2.12635053
82Duodenal stenosis (HP:0100867)2.12635053
83Short ribs (HP:0000773)2.12110809
84Facial cleft (HP:0002006)2.09428638
85Abnormality of dental color (HP:0011073)2.09415138
86Inability to walk (HP:0002540)2.08100593
87Carpal bone hypoplasia (HP:0001498)2.07309789
88Atrophy/Degeneration involving motor neurons (HP:0007373)2.06604820
89Tubular atrophy (HP:0000092)2.05888841
90Central scotoma (HP:0000603)2.05639262
91Bile duct proliferation (HP:0001408)2.04474077
92Abnormal biliary tract physiology (HP:0012439)2.04474077
93Genetic anticipation (HP:0003743)2.04085323
94Postaxial foot polydactyly (HP:0001830)2.01684188
95Facial hemangioma (HP:0000329)2.00527684
96Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.7730320
97Elevated erythrocyte sedimentation rate (HP:0003565)1.99572276
98Papillary thyroid carcinoma (HP:0002895)1.99136218
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97207547
100Absent epiphyses (HP:0010577)1.97207547
101Hypoproteinemia (HP:0003075)1.97070712
102Abnormal delayed hypersensitivity skin test (HP:0002963)1.96995616
103Thyroiditis (HP:0100646)1.96595059
104Aplasia/Hypoplasia of the fibula (HP:0006492)1.95328939
105Amelogenesis imperfecta (HP:0000705)1.94730529
106Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94060335
107Abnormal protein N-linked glycosylation (HP:0012347)1.94060335
108Abnormal protein glycosylation (HP:0012346)1.94060335
109Abnormal glycosylation (HP:0012345)1.94060335
110Medulloblastoma (HP:0002885)1.93643827
111Photophobia (HP:0000613)1.93402002
112Polydipsia (HP:0001959)1.93180300
113Abnormal drinking behavior (HP:0030082)1.93180300
114Anencephaly (HP:0002323)1.92667150
115Impaired proprioception (HP:0010831)1.92048559
116Prominent nose (HP:0000448)1.90956534
117Methylmalonic acidemia (HP:0002912)1.90812254
118Cerebellar dysplasia (HP:0007033)1.90223064
119Facial diplegia (HP:0001349)1.90084516
120Tubulointerstitial abnormality (HP:0001969)1.88968641
121Decreased central vision (HP:0007663)1.88934569
122Type I transferrin isoform profile (HP:0003642)1.87076962
123Breast carcinoma (HP:0003002)1.86867939
124Birth length less than 3rd percentile (HP:0003561)1.85504220
125Renal cortical cysts (HP:0000803)1.85430713
126Aplasia/Hypoplasia of the macula (HP:0008059)1.84879311
127Fair hair (HP:0002286)1.84585220
128IgG deficiency (HP:0004315)1.83147316
129Tongue fasciculations (HP:0001308)1.82762671
130Missing ribs (HP:0000921)1.82719317
131Optic neuritis (HP:0100653)1.82684552
132Retrobulbar optic neuritis (HP:0100654)1.82684552
133Median cleft lip (HP:0000161)1.81398325
134Concave nail (HP:0001598)1.81257886
135Volvulus (HP:0002580)1.81252549
136Cone-rod dystrophy (HP:0000548)1.80877410
137Ependymoma (HP:0002888)1.80827291
138Optic disc pallor (HP:0000543)1.79897382
139Spontaneous abortion (HP:0005268)1.79573712
140Pancreatic fibrosis (HP:0100732)1.79268917
141Absent thumb (HP:0009777)1.78813154
142Scotoma (HP:0000575)1.78355112
143Abnormality of the carotid arteries (HP:0005344)1.78015585
144Large for gestational age (HP:0001520)1.77818148
145Abnormality of vitamin B metabolism (HP:0004340)1.77809843
146Abnormality of the labia minora (HP:0012880)1.76933638
147Absent frontal sinuses (HP:0002688)1.76366778
148Short tibia (HP:0005736)1.75971722
149Breast hypoplasia (HP:0003187)1.75917167
150Sandal gap (HP:0001852)1.74858015
151Aplasia/Hypoplasia of the tongue (HP:0010295)1.74402995
152Progressive cerebellar ataxia (HP:0002073)1.74287702
153Myelodysplasia (HP:0002863)1.73644112
154Medial flaring of the eyebrow (HP:0010747)1.73432015
155Oligodactyly (HP:0012165)1.72506358
156Keratoconus (HP:0000563)1.70591221
157Increased corneal curvature (HP:0100692)1.70591221
158Clubbing of toes (HP:0100760)1.70308290
159Aplasia/Hypoplasia affecting the retina (HP:0008061)1.70030347
160Increased CSF lactate (HP:0002490)1.69551088
161Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.68727874
162Metaphyseal dysplasia (HP:0100255)1.68290580
163Type II diabetes mellitus (HP:0005978)1.68275973
164Gastrointestinal atresia (HP:0002589)1.68242871
165Rhabdomyosarcoma (HP:0002859)1.68173499
166Febrile seizures (HP:0002373)1.67889739
1673-Methylglutaconic aciduria (HP:0003535)1.67143467
168Oculomotor apraxia (HP:0000657)1.64030534
169Hypoplasia of the radius (HP:0002984)1.61064783
170Abnormal lung lobation (HP:0002101)1.60945554
171Truncal obesity (HP:0001956)1.59481792
172Patellar aplasia (HP:0006443)1.58918742
173Agnosia (HP:0010524)1.58473383
174High pitched voice (HP:0001620)1.58459849
175Absent radius (HP:0003974)1.57251616
176Abnormality of the duodenum (HP:0002246)1.56912157
177Premature ovarian failure (HP:0008209)1.56718701
178Abnormality of the renal cortex (HP:0011035)1.55722238
179Congenital hepatic fibrosis (HP:0002612)1.55528878
180Muscle fibrillation (HP:0010546)1.55127752
181Increased nuchal translucency (HP:0010880)1.54416098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.65207404
2PDK46.65207404
3FRK5.31872937
4MAP4K25.16744337
5CDC74.44982132
6PDK24.19304270
7NEK23.68230764
8WEE13.35085600
9TXK2.92921870
10ADRBK22.84630335
11CDK122.75440129
12TTK2.72969813
13TAOK32.51807458
14ACVR1B2.22974299
15PNCK2.21969977
16NUAK12.07023983
17PLK42.04868925
18TESK12.03073379
19OXSR11.90446779
20GRK11.88221764
21PRKD31.85530929
22ICK1.84288603
23PLK11.83437730
24CHEK21.76583227
25BRSK21.73052599
26ATR1.68346376
27BUB11.68293884
28PIK3CG1.62732959
29MAPK131.59697585
30INSRR1.59683924
31STK31.54206253
32STK38L1.51492378
33EIF2AK11.51026073
34CHEK11.45780275
35PTK2B1.36490421
36BMPR21.34818478
37NEK11.34513176
38MST41.34069477
39DYRK31.33963599
40MAP3K121.32074081
41EEF2K1.23188468
42MAP4K11.20237265
43SRPK11.18082388
44CCNB11.16926041
45ATM1.14917395
46CSF1R1.13207807
47FLT31.10189195
48PASK1.09545279
49PLK21.08487456
50CDK71.04919435
51KIT1.04762834
52IRAK11.03723979
53BRSK11.02521382
54AURKB1.01449056
55TEC0.99512252
56SIK30.98842371
57WNK40.98832579
58SIK20.95877105
59ADRBK10.95157460
60PLK30.94126562
61NLK0.93623154
62IKBKB0.93578327
63STK100.93223655
64TYRO30.92038392
65CDK190.89719920
66CDK40.87474492
67STK390.86588696
68FES0.85946732
69BRAF0.85740270
70STK380.82876014
71ITK0.82282561
72TRPM70.81066537
73AKT30.79989285
74TNIK0.79970394
75TNK20.79371215
76TGFBR10.79092785
77STK40.78443737
78LATS10.77093169
79PRKCE0.75417215
80CDK20.73783665
81BRD40.73259902
82AURKA0.71953511
83VRK10.71366827
84MAP3K60.69981065
85TRIM280.66486564
86BLK0.65673301
87MELK0.65255412
88ERBB30.65093187
89CDK10.64368148
90PAK30.63933418
91DAPK20.62673241
92SYK0.59200688
93MTOR0.53718487
94PRKAA20.53685031
95CDK90.53367481
96NEK60.53191176
97IRAK40.52955064
98MAP3K80.49540883
99PRKCG0.47901856
100PRKCQ0.47781851
101JAK30.47378336
102LATS20.47205657
103MKNK20.47064100
104LYN0.46734013
105IKBKE0.45922689
106CSNK1G10.45141653
107CAMK1G0.45000957
108WNK10.44652474
109GRK60.43890505
110HCK0.43271770
111PRKG10.43138546
112TSSK60.42905052
113RPS6KB20.42210916
114GRK70.41192862
115PAK10.40685606
116MAP3K140.40573223
117IGF1R0.40360691
118PINK10.38473066
119BTK0.37485277
120EIF2AK20.37336693
121MKNK10.37305457
122MAP3K40.36891536
123PRKDC0.36491344
124PIM10.36135144
125CSNK2A20.35451761
126CSNK2A10.35009418
127TAF10.34853813
128SGK20.34839945
129TGFBR20.34627674
130RPS6KB10.34451945
131STK160.33879501
132CSNK1D0.33633515
133RPS6KA40.33615561
134ABL10.32797500
135CHUK0.32201722
136TIE10.31923268
137MATK0.31908493
138JAK20.31429651
139MAP3K50.30884329
140EIF2AK30.30831934
141CDK60.30434033
142RIPK40.30299580
143CDK80.29299573
144PDK10.29154818
145CAMK2A0.28996355
146STK240.28585840
147CASK0.28203047
148PRKCI0.27932489
149TESK20.27729857
150MAP2K70.27317141
151LCK0.26564735
152TAOK10.26510316
153DYRK1B0.26192512
154GSK3B0.26080021
155MAP2K60.25964603
156MAPK140.22419024
157PRKAA10.22182396
158CDK30.21460512
159CSNK1E0.20983569
160TLK10.20279974
161MARK30.19108487
162WNK30.18806693
163PBK0.18062898
164MAPKAPK30.16831080
165BMPR1B0.16608416
166SCYL20.14174844
167MAPK10.14137873
168RAF10.14068551
169MAPK100.13178330
170EPHA20.12704619
171MAPK80.12409218
172ZAK0.10721438
173PAK40.10391205
174AKT10.10010600

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030224.10864372
2Fanconi anemia pathway_Homo sapiens_hsa034603.90782330
3DNA replication_Homo sapiens_hsa030303.81921986
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.76493145
5Homologous recombination_Homo sapiens_hsa034403.66468914
6Mismatch repair_Homo sapiens_hsa034303.58992353
7RNA transport_Homo sapiens_hsa030133.46262242
8Cell cycle_Homo sapiens_hsa041103.24181341
9Base excision repair_Homo sapiens_hsa034102.68490445
10mRNA surveillance pathway_Homo sapiens_hsa030152.63874296
11Nucleotide excision repair_Homo sapiens_hsa034202.60010272
12Vitamin B6 metabolism_Homo sapiens_hsa007502.58950834
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55157072
14Spliceosome_Homo sapiens_hsa030402.53631113
15Non-homologous end-joining_Homo sapiens_hsa034502.39158133
16RNA degradation_Homo sapiens_hsa030182.31604919
17Phototransduction_Homo sapiens_hsa047442.30248299
18Oocyte meiosis_Homo sapiens_hsa041142.25949557
19Type I diabetes mellitus_Homo sapiens_hsa049402.20231912
20Graft-versus-host disease_Homo sapiens_hsa053322.18159226
21Asthma_Homo sapiens_hsa053102.15559421
22Butanoate metabolism_Homo sapiens_hsa006502.11667954
23Allograft rejection_Homo sapiens_hsa053302.10964792
24Olfactory transduction_Homo sapiens_hsa047402.09284866
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.08629874
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.07610355
27Maturity onset diabetes of the young_Homo sapiens_hsa049502.07310008
28Intestinal immune network for IgA production_Homo sapiens_hsa046722.01856775
29RNA polymerase_Homo sapiens_hsa030201.97636307
30Caffeine metabolism_Homo sapiens_hsa002321.97427295
31Pentose phosphate pathway_Homo sapiens_hsa000301.96694193
32Autoimmune thyroid disease_Homo sapiens_hsa053201.87593757
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86923126
34Proteasome_Homo sapiens_hsa030501.85586490
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.80429631
36Selenocompound metabolism_Homo sapiens_hsa004501.76492337
37Pyrimidine metabolism_Homo sapiens_hsa002401.75208732
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72790948
39Nitrogen metabolism_Homo sapiens_hsa009101.71156654
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68549180
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64870551
42Dorso-ventral axis formation_Homo sapiens_hsa043201.64576751
43Regulation of autophagy_Homo sapiens_hsa041401.62734374
44p53 signaling pathway_Homo sapiens_hsa041151.59803971
45Pyruvate metabolism_Homo sapiens_hsa006201.55983082
46One carbon pool by folate_Homo sapiens_hsa006701.50742482
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47850436
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.46515194
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.41328471
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.38200383
51Purine metabolism_Homo sapiens_hsa002301.35612450
52Antigen processing and presentation_Homo sapiens_hsa046121.34002677
53Linoleic acid metabolism_Homo sapiens_hsa005911.32805838
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31951055
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.29918238
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26938417
57Tryptophan metabolism_Homo sapiens_hsa003801.23115535
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.19416833
59Protein export_Homo sapiens_hsa030601.18206416
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12966560
61Epstein-Barr virus infection_Homo sapiens_hsa051691.00717159
62Huntingtons disease_Homo sapiens_hsa050160.98859599
63ABC transporters_Homo sapiens_hsa020100.98511810
64Glucagon signaling pathway_Homo sapiens_hsa049220.96307122
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.94439554
66Rheumatoid arthritis_Homo sapiens_hsa053230.94384334
67Viral carcinogenesis_Homo sapiens_hsa052030.94355212
68Herpes simplex infection_Homo sapiens_hsa051680.94078975
69Hematopoietic cell lineage_Homo sapiens_hsa046400.91629790
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89311282
71Systemic lupus erythematosus_Homo sapiens_hsa053220.88735277
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87932167
73Taste transduction_Homo sapiens_hsa047420.86126486
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86032824
75Chemical carcinogenesis_Homo sapiens_hsa052040.85631293
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.84207605
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83579805
78Lysine degradation_Homo sapiens_hsa003100.83136145
79Salivary secretion_Homo sapiens_hsa049700.82281187
80Biosynthesis of amino acids_Homo sapiens_hsa012300.82019091
81Leishmaniasis_Homo sapiens_hsa051400.81716651
82Fatty acid biosynthesis_Homo sapiens_hsa000610.80811475
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80014851
84Sphingolipid metabolism_Homo sapiens_hsa006000.79956181
85Circadian rhythm_Homo sapiens_hsa047100.79137864
86Calcium signaling pathway_Homo sapiens_hsa040200.76841164
87Serotonergic synapse_Homo sapiens_hsa047260.76293312
88Ovarian steroidogenesis_Homo sapiens_hsa049130.76081917
89African trypanosomiasis_Homo sapiens_hsa051430.74343990
90Glycerolipid metabolism_Homo sapiens_hsa005610.72659256
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.71545199
92Morphine addiction_Homo sapiens_hsa050320.71050101
93HTLV-I infection_Homo sapiens_hsa051660.70874756
94Staphylococcus aureus infection_Homo sapiens_hsa051500.70833126
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66460399
96Propanoate metabolism_Homo sapiens_hsa006400.66132120
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.62394058
98Nicotine addiction_Homo sapiens_hsa050330.56718227
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56237735
100Tuberculosis_Homo sapiens_hsa051520.55549261
101Carbon metabolism_Homo sapiens_hsa012000.54339398
102Peroxisome_Homo sapiens_hsa041460.52575209
103Insulin secretion_Homo sapiens_hsa049110.47211119
104Ether lipid metabolism_Homo sapiens_hsa005650.46869602
105Retinol metabolism_Homo sapiens_hsa008300.46590339
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46466934
107TGF-beta signaling pathway_Homo sapiens_hsa043500.45074477
108Long-term depression_Homo sapiens_hsa047300.42905002
109Circadian entrainment_Homo sapiens_hsa047130.42200484
110MicroRNAs in cancer_Homo sapiens_hsa052060.39483650
111Influenza A_Homo sapiens_hsa051640.37354353
112Ribosome_Homo sapiens_hsa030100.35287618
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35246667
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.34814584
115Platelet activation_Homo sapiens_hsa046110.34204315
116Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33083722
117Glutathione metabolism_Homo sapiens_hsa004800.32494116
118Renin-angiotensin system_Homo sapiens_hsa046140.32469515
119Oxidative phosphorylation_Homo sapiens_hsa001900.31906759
120Collecting duct acid secretion_Homo sapiens_hsa049660.31663865
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31303537
122Fructose and mannose metabolism_Homo sapiens_hsa000510.31285777
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.30211032
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29645573
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29268282
126Small cell lung cancer_Homo sapiens_hsa052220.26400208
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25545455
128Legionellosis_Homo sapiens_hsa051340.23840984
129Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23095322
130Thyroid cancer_Homo sapiens_hsa052160.21748658
131Adherens junction_Homo sapiens_hsa045200.21501970
132Arachidonic acid metabolism_Homo sapiens_hsa005900.21123604
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20593808
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.20433847
135Alcoholism_Homo sapiens_hsa050340.19117689
136Hippo signaling pathway_Homo sapiens_hsa043900.18730869
137Inositol phosphate metabolism_Homo sapiens_hsa005620.18560181
138AMPK signaling pathway_Homo sapiens_hsa041520.18044627
139Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17958097
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.17411599
141Primary immunodeficiency_Homo sapiens_hsa053400.16072035
142mTOR signaling pathway_Homo sapiens_hsa041500.15233777
143Notch signaling pathway_Homo sapiens_hsa043300.15018023
144VEGF signaling pathway_Homo sapiens_hsa043700.12722127
145Colorectal cancer_Homo sapiens_hsa052100.11891164
146Metabolic pathways_Homo sapiens_hsa011000.11280168
147Hedgehog signaling pathway_Homo sapiens_hsa043400.09123593
148Wnt signaling pathway_Homo sapiens_hsa043100.08985985
149Measles_Homo sapiens_hsa051620.08813357
150Fat digestion and absorption_Homo sapiens_hsa049750.07987146
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.07624100
152Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07571187
153T cell receptor signaling pathway_Homo sapiens_hsa046600.07387013
154HIF-1 signaling pathway_Homo sapiens_hsa040660.06218688
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.06179227
156Phosphatidylinositol signaling system_Homo sapiens_hsa040700.05763332
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.05717938
158Tight junction_Homo sapiens_hsa045300.05305799
159Estrogen signaling pathway_Homo sapiens_hsa049150.05210474
160Prostate cancer_Homo sapiens_hsa052150.04525326
161B cell receptor signaling pathway_Homo sapiens_hsa046620.04368775
162NF-kappa B signaling pathway_Homo sapiens_hsa040640.03611136
163Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.03484518

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