RBM23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the U2AF-like family of RNA binding proteins. This protein interacts with some steroid nuclear receptors, localizes to the promoter of a steroid- responsive gene, and increases transcription of steroid-responsive transcriptional reporters in a hormone-dependent manner. It is also implicated in the steroid receptor-dependent regulation of alternative splicing. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.64629961
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.64629961
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.30424275
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.28939972
5positive regulation of gamma-delta T cell activation (GO:0046645)4.18786727
6positive regulation by symbiont of host defense response (GO:0052509)4.05722446
7modulation by symbiont of host defense response (GO:0052031)4.05722446
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.05722446
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.05722446
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.05722446
11modulation by symbiont of host immune response (GO:0052553)4.05722446
12antigen processing and presentation of endogenous antigen (GO:0019883)4.04661409
13L-fucose catabolic process (GO:0042355)4.03062725
14fucose catabolic process (GO:0019317)4.03062725
15L-fucose metabolic process (GO:0042354)4.03062725
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03011980
17regulation of B cell receptor signaling pathway (GO:0050855)3.83778926
18microglial cell activation (GO:0001774)3.62416651
19regulation of interferon-beta biosynthetic process (GO:0045357)3.55650677
20negative regulation of interleukin-12 production (GO:0032695)3.51258250
21activated T cell proliferation (GO:0050798)3.51179262
22negative regulation of interleukin-1 production (GO:0032692)3.50161375
23negative regulation of interleukin-1 beta production (GO:0032691)3.49712515
24negative regulation of lymphocyte mediated immunity (GO:0002707)3.45655275
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.35594989
26neutrophil mediated immunity (GO:0002446)3.33388600
27cilium or flagellum-dependent cell motility (GO:0001539)3.28771799
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.26840262
29neural tube formation (GO:0001841)3.24342720
30macrophage activation involved in immune response (GO:0002281)3.21774602
31tolerance induction (GO:0002507)3.16540210
32neutrophil activation involved in immune response (GO:0002283)3.14798362
33superoxide anion generation (GO:0042554)3.13052446
34cellular extravasation (GO:0045123)3.11035021
35regulation of gamma-delta T cell activation (GO:0046643)3.10494724
36negative T cell selection (GO:0043383)3.10379156
37negative thymic T cell selection (GO:0045060)3.06323790
38negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.05438813
39neutrophil activation (GO:0042119)3.04232465
40regulation of MHC class I biosynthetic process (GO:0045343)3.02537050
41regulation of interleukin-6 biosynthetic process (GO:0045408)3.02082025
42cellular response to interleukin-15 (GO:0071350)3.01270127
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.00354155
44DNA deamination (GO:0045006)2.99810610
45leukocyte aggregation (GO:0070486)2.99087583
46negative regulation of T cell mediated immunity (GO:0002710)2.97177064
47myeloid leukocyte mediated immunity (GO:0002444)2.94319860
48response to host immune response (GO:0052572)2.92918517
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.92918517
50regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90227497
51negative regulation of T-helper cell differentiation (GO:0045623)2.89249752
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89249752
53macrophage activation (GO:0042116)2.87121126
54epithelial cilium movement (GO:0003351)2.86963165
55interferon-gamma secretion (GO:0072643)2.83638909
56response to interleukin-15 (GO:0070672)2.83052296
57negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.82190814
58regulation of interferon-alpha production (GO:0032647)2.80455373
59negative regulation of interleukin-6 production (GO:0032715)2.79903020
60negative regulation of cAMP-mediated signaling (GO:0043951)2.79359073
61immunoglobulin mediated immune response (GO:0016064)2.79354987
62negative regulation of immunoglobulin mediated immune response (GO:0002890)2.78924312
63negative regulation of B cell mediated immunity (GO:0002713)2.78924312
64detection of other organism (GO:0098543)2.78039904
65response to type I interferon (GO:0034340)2.78020313
66positive regulation of interferon-alpha production (GO:0032727)2.77453435
67respiratory burst (GO:0045730)2.75648737
68positive regulation of mast cell activation (GO:0033005)2.75429375
69response to peptidoglycan (GO:0032494)2.73765279
70B cell receptor signaling pathway (GO:0050853)2.70002683
71regulation of memory T cell differentiation (GO:0043380)2.69925314
72negative regulation of adaptive immune response (GO:0002820)2.69645725
73germinal center formation (GO:0002467)2.68945145
74type I interferon signaling pathway (GO:0060337)2.68920129
75cellular response to type I interferon (GO:0071357)2.68920129
76regulation of mast cell activation (GO:0033003)2.67579597
77regulation of gamma-delta T cell differentiation (GO:0045586)2.67569445
78positive regulation of antigen processing and presentation (GO:0002579)2.66632419
79cilium movement (GO:0003341)2.65391926
80regulation of interleukin-12 biosynthetic process (GO:0045075)2.64129791
81granulocyte activation (GO:0036230)2.63019052
82positive regulation of interleukin-1 beta secretion (GO:0050718)2.61869770
83positive regulation of defense response to virus by host (GO:0002230)2.60672947
84negative regulation of leukocyte mediated immunity (GO:0002704)2.59490857
85regulation of T cell mediated cytotoxicity (GO:0001914)2.59060942
86positive regulation of interferon-beta production (GO:0032728)2.58601064
87dendritic cell migration (GO:0036336)2.55040946
88positive regulation of T cell mediated cytotoxicity (GO:0001916)2.54424324
89regulation of alpha-beta T cell proliferation (GO:0046640)2.54414762
90regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.54257572
91detection of bacterium (GO:0016045)2.53810767
92defense response to protozoan (GO:0042832)2.52005354
93interferon-gamma production (GO:0032609)2.51990369
94myeloid cell activation involved in immune response (GO:0002275)2.51776535
95response to host (GO:0075136)2.51290630
96response to host defenses (GO:0052200)2.51290630
97response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.51290630
98regulation of B cell apoptotic process (GO:0002902)2.51269108
99cellular response to exogenous dsRNA (GO:0071360)2.50504298
100positive regulation of granulocyte differentiation (GO:0030854)2.49663841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.14654252
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.65821156
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.05441448
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98519481
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.84856923
6ZNF274_21170338_ChIP-Seq_K562_Hela2.84180498
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.82646995
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65570452
9NOTCH1_21737748_ChIP-Seq_TLL_Human2.38975697
10RUNX_20019798_ChIP-Seq_JUKART_Human2.17153142
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10367384
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.08212435
13MYB_26560356_Chip-Seq_TH2_Human1.97226759
14IRF8_27001747_Chip-Seq_BMDM_Mouse1.96797013
15GATA3_26560356_Chip-Seq_TH2_Human1.92051416
16GBX2_23144817_ChIP-Seq_PC3_Human1.82360209
17IRF1_19129219_ChIP-ChIP_H3396_Human1.80235090
18ER_23166858_ChIP-Seq_MCF-7_Human1.70098293
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67492891
20GATA3_27048872_Chip-Seq_THYMUS_Human1.66499871
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64486775
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64152303
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62308646
24SCL_19346495_ChIP-Seq_HPC-7_Human1.62059570
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61081994
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.60247419
27SPI1_23547873_ChIP-Seq_NB4_Human1.59386152
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58359240
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48341555
30SMRT_27268052_Chip-Seq_Bcells_Human1.44390172
31VDR_24787735_ChIP-Seq_THP-1_Human1.41855316
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.40874690
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.39252077
34* MYB_26560356_Chip-Seq_TH1_Human1.39172326
35EWS_26573619_Chip-Seq_HEK293_Human1.38190963
36IGF1R_20145208_ChIP-Seq_DFB_Human1.30178354
37VDR_22108803_ChIP-Seq_LS180_Human1.30076682
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28463736
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25475473
40TP53_22573176_ChIP-Seq_HFKS_Human1.23250220
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22269789
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21837530
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21837530
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21506477
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21097526
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20964951
47VDR_23849224_ChIP-Seq_CD4+_Human1.20788310
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19505160
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19384038
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.19293234
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18782230
52CIITA_25753668_ChIP-Seq_RAJI_Human1.18244270
53TAF15_26573619_Chip-Seq_HEK293_Human1.15611229
54PRDM14_20953172_ChIP-Seq_ESCs_Human1.15600538
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15585058
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.14733368
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14440691
58BCAT_22108803_ChIP-Seq_LS180_Human1.14267175
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13744096
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.13182274
61SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11314990
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11069047
63STAT3_23295773_ChIP-Seq_U87_Human1.10405343
64SPI1_23127762_ChIP-Seq_K562_Human1.09050649
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.08167445
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08077133
67GATA3_26560356_Chip-Seq_TH1_Human1.05812124
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05335249
69GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.04705270
70P300_19829295_ChIP-Seq_ESCs_Human1.04561499
71TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.04468167
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03448229
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.02666124
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00527762
75FUS_26573619_Chip-Seq_HEK293_Human0.99619591
76TCF4_23295773_ChIP-Seq_U87_Human0.98916452
77FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98725929
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98061623
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97753949
80VDR_24763502_ChIP-Seq_THP-1_Human0.97517550
81AR_20517297_ChIP-Seq_VCAP_Human0.97475320
82LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96709419
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94888128
84STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94879780
85ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93610635
86FOXA1_25329375_ChIP-Seq_VCAP_Human0.92493913
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92493913
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91308403
89FLI1_21867929_ChIP-Seq_TH2_Mouse0.89699766
90FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89011636
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88534406
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87431508
93CBP_20019798_ChIP-Seq_JUKART_Human0.87431508
94* HOXB7_26014856_ChIP-Seq_BT474_Human0.87184192
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.87002450
96* MAF_26560356_Chip-Seq_TH1_Human0.84488380
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84176103
98NCOR_22424771_ChIP-Seq_293T_Human0.83813689
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83228174
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82986739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.93682865
2MP0001835_abnormal_antigen_presentation3.03894900
3MP0001800_abnormal_humoral_immune2.59807258
4MP0000569_abnormal_digit_pigmentation2.52913945
5MP0000685_abnormal_immune_system2.47813858
6MP0005671_abnormal_response_to2.45797040
7MP0003436_decreased_susceptibility_to2.40511977
8MP0003195_calcinosis2.37106645
9MP0005387_immune_system_phenotype2.33293392
10MP0001790_abnormal_immune_system2.33293392
11MP0003303_peritoneal_inflammation2.32192188
12MP0002277_abnormal_respiratory_mucosa2.14741825
13MP0002723_abnormal_immune_serum2.13205278
14MP0001986_abnormal_taste_sensitivity2.05239601
15MP0005000_abnormal_immune_tolerance2.05073036
16MP0002452_abnormal_antigen_presenting2.04953294
17MP0002419_abnormal_innate_immunity2.03485115
18MP0009785_altered_susceptibility_to2.02682027
19MP0002420_abnormal_adaptive_immunity1.99402569
20MP0003763_abnormal_thymus_physiology1.99130096
21MP0002148_abnormal_hypersensitivity_rea1.98715249
22MP0008877_abnormal_DNA_methylation1.98465491
23MP0002653_abnormal_ependyma_morphology1.97778895
24MP0001819_abnormal_immune_cell1.97398005
25MP0005025_abnormal_response_to1.91373605
26MP0002102_abnormal_ear_morphology1.81660074
27MP0005174_abnormal_tail_pigmentation1.81335826
28MP0009764_decreased_sensitivity_to1.77463746
29MP0004043_abnormal_pH_regulation1.70924544
30MP0005310_abnormal_salivary_gland1.65545306
31MP0002405_respiratory_system_inflammati1.63921472
32MP0002138_abnormal_hepatobiliary_system1.63019353
33MP0004381_abnormal_hair_follicle1.61750730
34MP0002928_abnormal_bile_duct1.58670434
35MP0003787_abnormal_imprinting1.54370745
36MP0005075_abnormal_melanosome_morpholog1.52283256
37MP0000716_abnormal_immune_system1.51115569
38MP0000427_abnormal_hair_cycle1.47904363
39MP0003646_muscle_fatigue1.47398018
40MP0000015_abnormal_ear_pigmentation1.44370513
41MP0002398_abnormal_bone_marrow1.43618063
42MP0008057_abnormal_DNA_replication1.42365285
43MP0000689_abnormal_spleen_morphology1.41493969
44MP0003300_gastrointestinal_ulcer1.40075850
45MP0001845_abnormal_inflammatory_respons1.36523377
46MP0006082_CNS_inflammation1.34793396
47MP0000372_irregular_coat_pigmentation1.33860345
48MP0009278_abnormal_bone_marrow1.27048516
49MP0003866_abnormal_defecation1.26454710
50MP0001533_abnormal_skeleton_physiology1.25498506
51MP0010155_abnormal_intestine_physiology1.25371745
52MP0002132_abnormal_respiratory_system1.25220010
53MP0002722_abnormal_immune_system1.22787594
54MP0002876_abnormal_thyroid_physiology1.22622772
55MP0000703_abnormal_thymus_morphology1.21686474
56MP0005253_abnormal_eye_physiology1.21583859
57MP0004883_abnormal_blood_vessel1.17966794
58MP0005551_abnormal_eye_electrophysiolog1.15987402
59MP0001501_abnormal_sleep_pattern1.10543452
60MP0003183_abnormal_peptide_metabolism1.09887792
61MP0000383_abnormal_hair_follicle1.09813666
62MP0002429_abnormal_blood_cell1.08011909
63MP0002166_altered_tumor_susceptibility1.07879899
64MP0001873_stomach_inflammation1.07547436
65MP0002163_abnormal_gland_morphology1.06575406
66MP0008872_abnormal_physiological_respon1.02002341
67MP0001545_abnormal_hematopoietic_system1.00212930
68MP0005397_hematopoietic_system_phenotyp1.00212930
69MP0003172_abnormal_lysosome_physiology0.98480265
70MP0002095_abnormal_skin_pigmentation0.98314645
71MP0002009_preneoplasia0.92705458
72MP0003011_delayed_dark_adaptation0.91313777
73MP0008469_abnormal_protein_level0.90510964
74MP0001968_abnormal_touch/_nociception0.89934814
75MP0001485_abnormal_pinna_reflex0.89407463
76MP0004742_abnormal_vestibular_system0.88298942
77MP0002396_abnormal_hematopoietic_system0.88159944
78MP0003252_abnormal_bile_duct0.88157807
79MP0003656_abnormal_erythrocyte_physiolo0.88151905
80MP0000371_diluted_coat_color0.87870546
81MP0008961_abnormal_basal_metabolism0.87614205
82MP0004947_skin_inflammation0.86400355
83MP0002693_abnormal_pancreas_physiology0.85730544
84MP0003045_fibrosis0.80168594
85MP0001663_abnormal_digestive_system0.80016239
86MP0004142_abnormal_muscle_tone0.79573224
87MP0005266_abnormal_metabolism0.78850787
88MP0002638_abnormal_pupillary_reflex0.78314826
89MP0000470_abnormal_stomach_morphology0.76516056
90MP0002332_abnormal_exercise_endurance0.74299520
91MP0004808_abnormal_hematopoietic_stem0.73575359
92MP0002837_dystrophic_cardiac_calcinosis0.71984054
93MP0002006_tumorigenesis0.70774696
94MP0003878_abnormal_ear_physiology0.68963878
95MP0005377_hearing/vestibular/ear_phenot0.68963878
96MP0009765_abnormal_xenobiotic_induced0.66257430
97MP0009745_abnormal_behavioral_response0.64451251
98MP0004484_altered_response_of0.63781134
99MP0000631_abnormal_neuroendocrine_gland0.63550535
100MP0009046_muscle_twitch0.63469972

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)4.01217570
2Pancreatic cysts (HP:0001737)3.96003981
3Recurrent bacterial skin infections (HP:0005406)3.67746962
4Abnormal delayed hypersensitivity skin test (HP:0002963)3.53115736
5Pancreatic fibrosis (HP:0100732)3.49310809
6Retrobulbar optic neuritis (HP:0100654)3.45072811
7Optic neuritis (HP:0100653)3.45072811
8Myositis (HP:0100614)3.41206385
9Recurrent abscess formation (HP:0002722)3.33661524
10Elevated erythrocyte sedimentation rate (HP:0003565)3.26514003
11Orchitis (HP:0100796)3.21837813
12Recurrent fungal infections (HP:0002841)3.18466702
13Eczematoid dermatitis (HP:0000976)3.17648518
14True hermaphroditism (HP:0010459)3.14848166
15Absent/shortened dynein arms (HP:0200106)2.98538032
16Dynein arm defect of respiratory motile cilia (HP:0012255)2.98538032
17Panhypogammaglobulinemia (HP:0003139)2.98255881
18Congenital stationary night blindness (HP:0007642)2.97511105
19Attenuation of retinal blood vessels (HP:0007843)2.91159011
20Molar tooth sign on MRI (HP:0002419)2.89679519
21Abnormality of midbrain morphology (HP:0002418)2.89679519
22Chronic mucocutaneous candidiasis (HP:0002728)2.79761340
23Recurrent cutaneous fungal infections (HP:0011370)2.79761340
24Nephronophthisis (HP:0000090)2.78950778
25Stomach cancer (HP:0012126)2.69213244
26Abnormal rod and cone electroretinograms (HP:0008323)2.66621191
27Recurrent skin infections (HP:0001581)2.64048460
28Encephalitis (HP:0002383)2.58830456
29Abnormality of the renal medulla (HP:0100957)2.58458128
30Cystic liver disease (HP:0006706)2.55508917
31Chronic otitis media (HP:0000389)2.55242109
32Hyperventilation (HP:0002883)2.55100345
33Abnormality of T cell number (HP:0011839)2.52087204
34Abnormal respiratory epithelium morphology (HP:0012253)2.50587741
35Abnormal respiratory motile cilium morphology (HP:0005938)2.50587741
36T lymphocytopenia (HP:0005403)2.49228793
37Chronic hepatic failure (HP:0100626)2.47542169
38Abnormal ciliary motility (HP:0012262)2.42659368
39Abnormality of the renal cortex (HP:0011035)2.41041155
40Hypochromic microcytic anemia (HP:0004840)2.40967673
41Absent rod-and cone-mediated responses on ERG (HP:0007688)2.38660004
42Agitation (HP:0000713)2.32624825
43Keratoconjunctivitis (HP:0001096)2.32390680
44Tubular atrophy (HP:0000092)2.26719058
45Abnormality of T cells (HP:0002843)2.24090727
46Abnormal drinking behavior (HP:0030082)2.23476102
47Polydipsia (HP:0001959)2.23476102
48Medial flaring of the eyebrow (HP:0010747)2.23470935
49Meningitis (HP:0001287)2.20068572
50Keratoconjunctivitis sicca (HP:0001097)2.19004317
51Abnormality of macrophages (HP:0004311)2.18734433
52Progressive inability to walk (HP:0002505)2.15900226
53Type II lissencephaly (HP:0007260)2.13278404
54Mediastinal lymphadenopathy (HP:0100721)2.12955935
55Absent speech (HP:0001344)2.12334956
56Genetic anticipation (HP:0003743)2.11865470
57Abolished electroretinogram (ERG) (HP:0000550)2.11758681
58Spontaneous hematomas (HP:0007420)2.10109915
59Gastrointestinal infarctions (HP:0005244)2.08504308
60Abnormality of T cell physiology (HP:0011840)2.08039682
61Abnormal respiratory motile cilium physiology (HP:0012261)2.07038701
62Furrowed tongue (HP:0000221)2.06887391
63Gaze-evoked nystagmus (HP:0000640)2.05736880
64Hemoptysis (HP:0002105)2.00150370
65Thyroiditis (HP:0100646)1.99545284
66Increased neuronal autofluorescent lipopigment (HP:0002074)1.98730986
67Lissencephaly (HP:0001339)1.98701280
68Hematochezia (HP:0002573)1.98194628
69Decreased circulating renin level (HP:0003351)1.97409079
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.97206405
71Asplenia (HP:0001746)1.97205648
72Hypochromic anemia (HP:0001931)1.96920596
73Hip dysplasia (HP:0001385)1.94656524
74Decreased electroretinogram (ERG) amplitude (HP:0000654)1.94157312
75Bony spicule pigmentary retinopathy (HP:0007737)1.88694593
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.88616656
77Vasculitis (HP:0002633)1.88123348
78Abnormal biliary tract physiology (HP:0012439)1.87807396
79Bile duct proliferation (HP:0001408)1.87807396
80IgG deficiency (HP:0004315)1.87149873
81Decreased central vision (HP:0007663)1.86813855
82Congenital hepatic fibrosis (HP:0002612)1.86794039
83Eosinophilia (HP:0001880)1.86717267
84Leukocytosis (HP:0001974)1.85957888
85Pendular nystagmus (HP:0012043)1.85826260
86Recurrent viral infections (HP:0004429)1.85186699
87Bronchiectasis (HP:0002110)1.83387170
88Prostate neoplasm (HP:0100787)1.82146344
89Clumsiness (HP:0002312)1.81221223
90Recurrent gram-negative bacterial infections (HP:0005420)1.80962292
91Inability to walk (HP:0002540)1.80677867
92Anencephaly (HP:0002323)1.80528489
93Recurrent sinusitis (HP:0011108)1.80497502
94Nephrogenic diabetes insipidus (HP:0009806)1.80044107
95Chronic diarrhea (HP:0002028)1.78567133
96Abnormality of eosinophils (HP:0001879)1.77931539
97Pulmonary infiltrates (HP:0002113)1.77378729
98Congenital sensorineural hearing impairment (HP:0008527)1.77365621
99Rhinitis (HP:0012384)1.76596885
100Increased cerebral lipofuscin (HP:0011813)1.76577823

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.47441107
2ACVR1B3.25005873
3BLK2.74227721
4BMPR1B2.70521779
5TAOK32.44504993
6MAP4K12.41599649
7RIPK42.27963903
8TXK2.13483749
9IRAK42.08187247
10DAPK22.02493876
11GRK61.90594311
12TNK21.87180830
13ADRBK21.82795273
14IKBKE1.78958801
15IRAK11.69621881
16WNK31.68659986
17CAMKK21.65327430
18IKBKB1.51125642
19TYK21.45039433
20BTK1.40324275
21SYK1.39800428
22GRK11.35966054
23MAP4K21.35852117
24CSK1.35005372
25TLK11.32875551
26FES1.30844372
27NLK1.28481364
28TEC1.24371644
29MAP2K61.23273162
30EPHA31.16301268
31MAPK131.16144019
32LYN1.15355884
33HCK1.12769138
34PRKD21.11272055
35TRIM281.08975527
36ITK1.08833348
37MARK31.07441584
38MAP2K31.07076411
39MAP3K141.06315009
40PTK2B1.05347621
41INSRR1.03911577
42OXSR11.01318946
43NUAK11.00841997
44JAK31.00483067
45MAP3K40.98049035
46JAK10.93304530
47TAOK10.93290599
48JAK20.92648082
49MAP3K70.91017408
50CHUK0.89393474
51ADRBK10.85240392
52TGFBR10.85070038
53ZAP700.84977627
54FGR0.84189131
55LCK0.83714494
56KIT0.79245204
57CAMK1D0.77988581
58MAPKAPK30.77930011
59STK110.77333608
60PAK30.75504306
61TBK10.74223426
62YES10.73801721
63PRKCQ0.72157951
64FGFR20.71836379
65EPHB10.71382881
66CAMKK10.68458843
67CSF1R0.66591681
68ZAK0.66530532
69MAPK150.65620295
70CAMK40.65041236
71SGK20.63924691
72STK380.61847102
73HIPK20.61122652
74STK100.58831182
75BRSK20.53301992
76BRD40.52832560
77SIK20.50549222
78MELK0.49993776
79TRPM70.49674209
80PIM10.49530801
81RPS6KA60.48607363
82MAP2K40.48243560
83PDK10.48117753
84CSNK1A1L0.46859829
85RPS6KA50.46782456
86MKNK20.45408465
87MAP2K20.44750090
88GRK70.44541300
89PIK3CG0.43435999
90CSNK1G30.41619178
91PRKCZ0.40714314
92CDK190.39722965
93PINK10.37436368
94PRKAA20.36255573
95CSNK1G10.36071116
96CASK0.35750635
97MAPK110.33910385
98CSNK1G20.33533537
99SGK30.32886051
100PRKCH0.32670287

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.62183613
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.29183980
3Osteoclast differentiation_Homo sapiens_hsa043802.17379193
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.14073518
5Graft-versus-host disease_Homo sapiens_hsa053322.11556580
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.10859500
7Leishmaniasis_Homo sapiens_hsa051402.08603089
8Allograft rejection_Homo sapiens_hsa053302.07955293
9Type I diabetes mellitus_Homo sapiens_hsa049402.04513927
10Autoimmune thyroid disease_Homo sapiens_hsa053201.96696595
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.90452107
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87677611
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84686101
14Staphylococcus aureus infection_Homo sapiens_hsa051501.73625521
15Tuberculosis_Homo sapiens_hsa051521.70195460
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.66516404
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.64999763
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.59728041
19B cell receptor signaling pathway_Homo sapiens_hsa046621.56803214
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.55627537
21Asthma_Homo sapiens_hsa053101.52351963
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52296722
23T cell receptor signaling pathway_Homo sapiens_hsa046601.51314583
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50810683
25Jak-STAT signaling pathway_Homo sapiens_hsa046301.46848639
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46654197
27Measles_Homo sapiens_hsa051621.46638500
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.36397991
29Hematopoietic cell lineage_Homo sapiens_hsa046401.33740311
30Linoleic acid metabolism_Homo sapiens_hsa005911.32309457
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30919860
32Dorso-ventral axis formation_Homo sapiens_hsa043201.30141316
33Legionellosis_Homo sapiens_hsa051341.27652888
34Phototransduction_Homo sapiens_hsa047441.24598128
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22606791
36TNF signaling pathway_Homo sapiens_hsa046681.18976230
37Herpes simplex infection_Homo sapiens_hsa051681.16799435
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16616368
39Antigen processing and presentation_Homo sapiens_hsa046121.16166268
40Influenza A_Homo sapiens_hsa051641.14573194
41Regulation of autophagy_Homo sapiens_hsa041401.11678102
42Chemokine signaling pathway_Homo sapiens_hsa040621.11658922
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09241694
44Nitrogen metabolism_Homo sapiens_hsa009101.07989070
45Butanoate metabolism_Homo sapiens_hsa006501.03280133
46Collecting duct acid secretion_Homo sapiens_hsa049661.02677537
47Ether lipid metabolism_Homo sapiens_hsa005651.01158309
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00854333
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00201260
50ABC transporters_Homo sapiens_hsa020100.98686872
51Toxoplasmosis_Homo sapiens_hsa051450.94617906
52Rheumatoid arthritis_Homo sapiens_hsa053230.93995604
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90911931
54Homologous recombination_Homo sapiens_hsa034400.90376019
55Malaria_Homo sapiens_hsa051440.86415476
56Hepatitis C_Homo sapiens_hsa051600.86375275
57Maturity onset diabetes of the young_Homo sapiens_hsa049500.84228732
58FoxO signaling pathway_Homo sapiens_hsa040680.81486210
59Fanconi anemia pathway_Homo sapiens_hsa034600.80999770
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80488935
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80189466
62African trypanosomiasis_Homo sapiens_hsa051430.78164205
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77915299
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76749350
65Hepatitis B_Homo sapiens_hsa051610.75696352
66Arachidonic acid metabolism_Homo sapiens_hsa005900.75351932
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74965579
68Morphine addiction_Homo sapiens_hsa050320.72198813
69Phagosome_Homo sapiens_hsa041450.70854382
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67665467
71Lysosome_Homo sapiens_hsa041420.65578739
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65444695
73Selenocompound metabolism_Homo sapiens_hsa004500.65064723
74Tryptophan metabolism_Homo sapiens_hsa003800.59034140
75Basal transcription factors_Homo sapiens_hsa030220.58209794
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57221082
77Taste transduction_Homo sapiens_hsa047420.55341797
78Glycerolipid metabolism_Homo sapiens_hsa005610.54590458
79Serotonergic synapse_Homo sapiens_hsa047260.53099308
80Glycerophospholipid metabolism_Homo sapiens_hsa005640.52335871
81Type II diabetes mellitus_Homo sapiens_hsa049300.51124322
82Acute myeloid leukemia_Homo sapiens_hsa052210.50964097
83Inositol phosphate metabolism_Homo sapiens_hsa005620.49719242
84Ovarian steroidogenesis_Homo sapiens_hsa049130.49702444
85Apoptosis_Homo sapiens_hsa042100.45913980
86Choline metabolism in cancer_Homo sapiens_hsa052310.45688324
87Viral myocarditis_Homo sapiens_hsa054160.44744036
88Platelet activation_Homo sapiens_hsa046110.44446294
89Epstein-Barr virus infection_Homo sapiens_hsa051690.43492829
90Caffeine metabolism_Homo sapiens_hsa002320.42679715
91Prolactin signaling pathway_Homo sapiens_hsa049170.41075422
92MAPK signaling pathway_Homo sapiens_hsa040100.40720263
93Olfactory transduction_Homo sapiens_hsa047400.38439519
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38424702
95Viral carcinogenesis_Homo sapiens_hsa052030.35034780
96Non-small cell lung cancer_Homo sapiens_hsa052230.34966975
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.30045835
98Pertussis_Homo sapiens_hsa051330.29785038
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.27387191
100p53 signaling pathway_Homo sapiens_hsa041150.26726406

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