RBM22P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1water-soluble vitamin biosynthetic process (GO:0042364)6.54541002
2behavioral response to nicotine (GO:0035095)6.42210435
3monoubiquitinated protein deubiquitination (GO:0035520)5.11330243
4protein complex biogenesis (GO:0070271)4.83163148
5DNA deamination (GO:0045006)4.66563633
6mitochondrial respiratory chain complex assembly (GO:0033108)4.36016255
7negative regulation of membrane potential (GO:0045837)4.27812948
8negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.08742488
9cytochrome complex assembly (GO:0017004)3.97306094
10indolalkylamine metabolic process (GO:0006586)3.91550556
11mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80743899
12mitochondrial respiratory chain complex I assembly (GO:0032981)3.80743899
13NADH dehydrogenase complex assembly (GO:0010257)3.80743899
14base-excision repair, AP site formation (GO:0006285)3.67983899
15protein neddylation (GO:0045116)3.55357096
16kynurenine metabolic process (GO:0070189)3.47329965
17pseudouridine synthesis (GO:0001522)3.47093601
18sulfation (GO:0051923)3.45816684
19platelet dense granule organization (GO:0060155)3.42548977
20positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.39412643
21adaptation of signaling pathway (GO:0023058)3.37825002
22L-fucose catabolic process (GO:0042355)3.32155047
23fucose catabolic process (GO:0019317)3.32155047
24L-fucose metabolic process (GO:0042354)3.32155047
25indole-containing compound catabolic process (GO:0042436)3.25295688
26indolalkylamine catabolic process (GO:0046218)3.25295688
27tryptophan catabolic process (GO:0006569)3.25295688
28protein K48-linked deubiquitination (GO:0071108)3.24186310
29regulation of mitochondrial translation (GO:0070129)3.22492311
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21712465
31ATP synthesis coupled proton transport (GO:0015986)3.21712465
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.21093136
33pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18750983
34positive regulation of fatty acid transport (GO:2000193)3.17354327
35protein import into peroxisome matrix (GO:0016558)3.17343316
36serotonin metabolic process (GO:0042428)3.16722798
37primary amino compound metabolic process (GO:1901160)3.16293987
38negative regulation of telomere maintenance (GO:0032205)3.14857971
39protein polyglutamylation (GO:0018095)3.10282404
40negative regulation of transcription regulatory region DNA binding (GO:2000678)3.10171089
41kidney morphogenesis (GO:0060993)3.08751264
42chaperone-mediated protein transport (GO:0072321)3.07697829
43vitamin biosynthetic process (GO:0009110)3.07035415
44positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.04608223
45negative regulation of DNA-templated transcription, elongation (GO:0032785)3.02334717
46gamma-aminobutyric acid transport (GO:0015812)2.97953521
47indole-containing compound metabolic process (GO:0042430)2.95286458
483-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.91832524
49purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.91832524
50positive regulation of endothelial cell differentiation (GO:0045603)2.91615915
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91572786
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87669073
53negative regulation of systemic arterial blood pressure (GO:0003085)2.86916645
54preassembly of GPI anchor in ER membrane (GO:0016254)2.85662818
55negative regulation of mast cell activation (GO:0033004)2.85466190
56axoneme assembly (GO:0035082)2.85141082
57somite development (GO:0061053)2.83433715
58cellular response to ATP (GO:0071318)2.77762440
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77486481
60response to gravity (GO:0009629)2.77016019
61endoderm formation (GO:0001706)2.75546167
62cobalamin metabolic process (GO:0009235)2.74849248
63protein-cofactor linkage (GO:0018065)2.73828640
64regulation of mesoderm development (GO:2000380)2.73099749
65negative regulation of appetite (GO:0032099)2.72223485
66negative regulation of response to food (GO:0032096)2.72223485
67cell proliferation in forebrain (GO:0021846)2.72044796
68response to pheromone (GO:0019236)2.71201142
69epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.70964785
70regulation of endothelial cell differentiation (GO:0045601)2.70832959
71tryptophan metabolic process (GO:0006568)2.70493196
72mannosylation (GO:0097502)2.68235869
73pyrimidine nucleotide catabolic process (GO:0006244)2.68212237
74respiratory chain complex IV assembly (GO:0008535)2.67441849
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.67327069
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.66399947
77positive regulation of fatty acid oxidation (GO:0046321)2.65703392
78cytidine metabolic process (GO:0046087)2.63723599
79cytidine catabolic process (GO:0006216)2.63723599
80cytidine deamination (GO:0009972)2.63723599
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61946193
82transmission of nerve impulse (GO:0019226)2.60289997
83parturition (GO:0007567)2.59192102
84establishment of protein localization to mitochondrial membrane (GO:0090151)2.58799578
85intracellular protein transmembrane import (GO:0044743)2.55896679
86exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55471239
87GPI anchor metabolic process (GO:0006505)2.53958637
88regulation of action potential (GO:0098900)2.51936315
89glyoxylate metabolic process (GO:0046487)2.50899325
90magnesium ion transport (GO:0015693)2.50859209
91rhodopsin mediated signaling pathway (GO:0016056)2.49994916
92piRNA metabolic process (GO:0034587)2.49309503
93multicellular organism reproduction (GO:0032504)2.48964236
94negative regulation of T cell differentiation in thymus (GO:0033085)2.47947113
95photoreceptor cell development (GO:0042461)2.47315748
96replication fork processing (GO:0031297)2.46745594
97regulation of neurotransmitter uptake (GO:0051580)2.45786370
98epithelial cilium movement (GO:0003351)2.44002581
99aromatic amino acid family metabolic process (GO:0009072)2.43134747
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42075148

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.30325350
2EZH2_22144423_ChIP-Seq_EOC_Human3.27597642
3ZNF274_21170338_ChIP-Seq_K562_Hela3.23483733
4VDR_22108803_ChIP-Seq_LS180_Human3.14287495
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10074957
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32755688
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24546647
8GBX2_23144817_ChIP-Seq_PC3_Human2.22089815
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.04165088
10IRF1_19129219_ChIP-ChIP_H3396_Human2.03848944
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.02469482
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00581119
13EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.94074127
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.90233171
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.86612308
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82414450
17IGF1R_20145208_ChIP-Seq_DFB_Human1.79932501
18CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79127565
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.71212625
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69679206
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.69494030
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.64970961
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.61845304
24EWS_26573619_Chip-Seq_HEK293_Human1.59496849
25FUS_26573619_Chip-Seq_HEK293_Human1.59171114
26REST_21632747_ChIP-Seq_MESCs_Mouse1.55821820
27NCOR_22424771_ChIP-Seq_293T_Human1.53053694
28MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51277760
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49469058
30EZH2_27304074_Chip-Seq_ESCs_Mouse1.49380581
31ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48782762
32MYC_18940864_ChIP-ChIP_HL60_Human1.48110958
33TP53_22573176_ChIP-Seq_HFKS_Human1.46447694
34TAF15_26573619_Chip-Seq_HEK293_Human1.45841027
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.45454060
36P300_19829295_ChIP-Seq_ESCs_Human1.44739725
37CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43376903
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42690188
39IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42660559
40CBP_20019798_ChIP-Seq_JUKART_Human1.42660559
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40599481
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37981883
43ER_23166858_ChIP-Seq_MCF-7_Human1.36151574
44AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35346909
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35070286
46FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34963965
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.34963965
48JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.34190777
49EST1_17652178_ChIP-ChIP_JURKAT_Human1.32595338
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31972385
51CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.30785336
52BCAT_22108803_ChIP-Seq_LS180_Human1.30353626
53KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29612151
54GATA3_21878914_ChIP-Seq_MCF-7_Human1.28725708
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.27732407
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25909712
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25887443
58RNF2_27304074_Chip-Seq_NSC_Mouse1.25305938
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.22516083
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22291995
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21198507
62TAF2_19829295_ChIP-Seq_ESCs_Human1.20840737
63ERA_21632823_ChIP-Seq_H3396_Human1.17501838
64HOXB7_26014856_ChIP-Seq_BT474_Human1.17428292
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17408059
66NANOG_20526341_ChIP-Seq_ESCs_Human1.17212371
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16253304
68AR_20517297_ChIP-Seq_VCAP_Human1.14198169
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13746877
70MYC_19829295_ChIP-Seq_ESCs_Human1.12964841
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12212021
72PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09325726
73PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.09208386
74NANOG_19829295_ChIP-Seq_ESCs_Human1.08678307
75SOX2_19829295_ChIP-Seq_ESCs_Human1.08678307
76TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08656018
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.07714042
78VDR_23849224_ChIP-Seq_CD4+_Human1.06673210
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06492594
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06086183
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05756293
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.04764492
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04399619
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04399619
85STAT3_23295773_ChIP-Seq_U87_Human1.04106808
86P53_21459846_ChIP-Seq_SAOS-2_Human1.02896559
87SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.02603531
88RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.01957522
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.01115259
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00219607
91GATA3_26560356_Chip-Seq_TH2_Human0.99523767
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98123751
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98099817
94NFE2_27457419_Chip-Seq_LIVER_Mouse0.97712389
95SMAD4_21799915_ChIP-Seq_A2780_Human0.97007374
96TCF4_23295773_ChIP-Seq_U87_Human0.96851994
97SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95807363
98TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95059074
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94415372
100TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94401317

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue6.04816921
2MP0002837_dystrophic_cardiac_calcinosis4.76480869
3MP0001968_abnormal_touch/_nociception3.00484505
4MP0002736_abnormal_nociception_after2.97610362
5MP0006292_abnormal_olfactory_placode2.68179943
6MP0003011_delayed_dark_adaptation2.47508277
7MP0003122_maternal_imprinting2.37861698
8MP0002876_abnormal_thyroid_physiology2.12445396
9MP0005646_abnormal_pituitary_gland2.07038134
10MP0004133_heterotaxia2.04331259
11MP0003195_calcinosis1.96337400
12MP0004130_abnormal_muscle_cell1.89784692
13MP0008775_abnormal_heart_ventricle1.88317921
14MP0005551_abnormal_eye_electrophysiolog1.88046290
15MP0004885_abnormal_endolymph1.82578186
16MP0002102_abnormal_ear_morphology1.77315323
17MP0008877_abnormal_DNA_methylation1.76817332
18MP0008872_abnormal_physiological_respon1.76071788
19MP0008875_abnormal_xenobiotic_pharmacok1.71115794
20MP0003121_genomic_imprinting1.69116137
21MP0004145_abnormal_muscle_electrophysio1.67865133
22MP0006072_abnormal_retinal_apoptosis1.67195250
23MP0004742_abnormal_vestibular_system1.67154170
24MP0009046_muscle_twitch1.65611397
25MP0002653_abnormal_ependyma_morphology1.64598355
26MP0001905_abnormal_dopamine_level1.61713768
27MP0002272_abnormal_nervous_system1.61069498
28MP0001485_abnormal_pinna_reflex1.59470791
29MP0002735_abnormal_chemical_nociception1.58983147
30MP0002277_abnormal_respiratory_mucosa1.58809254
31MP0009745_abnormal_behavioral_response1.57955050
32MP0002160_abnormal_reproductive_system1.57671560
33MP0003787_abnormal_imprinting1.57240701
34MP0004142_abnormal_muscle_tone1.49240584
35MP0005389_reproductive_system_phenotype1.45843875
36MP0003890_abnormal_embryonic-extraembry1.38174046
37MP0008789_abnormal_olfactory_epithelium1.35701200
38MP0000631_abnormal_neuroendocrine_gland1.32650920
39MP0002938_white_spotting1.31608515
40MP0001486_abnormal_startle_reflex1.31538169
41MP0005670_abnormal_white_adipose1.30425376
42MP0001986_abnormal_taste_sensitivity1.30123493
43MP0002733_abnormal_thermal_nociception1.29419861
44MP0000049_abnormal_middle_ear1.24288878
45MP0005671_abnormal_response_to1.21897008
46MP0001970_abnormal_pain_threshold1.19283124
47MP0002638_abnormal_pupillary_reflex1.16740893
48MP0005253_abnormal_eye_physiology1.16170101
49MP0004147_increased_porphyrin_level1.16004873
50MP0002557_abnormal_social/conspecific_i1.14073143
51MP0003283_abnormal_digestive_organ1.13869754
52MP0001919_abnormal_reproductive_system1.13064051
53MP0002064_seizures1.12788556
54MP0003123_paternal_imprinting1.08993420
55MP0000537_abnormal_urethra_morphology1.08029956
56MP0005386_behavior/neurological_phenoty1.07515156
57MP0004924_abnormal_behavior1.07515156
58MP0006276_abnormal_autonomic_nervous1.07431292
59MP0005084_abnormal_gallbladder_morpholo1.06261194
60MP0002572_abnormal_emotion/affect_behav1.05147809
61MP0000230_abnormal_systemic_arterial1.03503265
62MP0003880_abnormal_central_pattern1.02119084
63MP0002928_abnormal_bile_duct1.00991057
64MP0001963_abnormal_hearing_physiology1.00563795
65MP0002163_abnormal_gland_morphology0.98014595
66MP0001984_abnormal_olfaction0.95735292
67MP0000026_abnormal_inner_ear0.95331580
68MP0005332_abnormal_amino_acid0.94528757
69MP0005645_abnormal_hypothalamus_physiol0.93940526
70MP0000427_abnormal_hair_cycle0.90810130
71MP0000372_irregular_coat_pigmentation0.90524763
72MP0001440_abnormal_grooming_behavior0.90104780
73MP0005410_abnormal_fertilization0.89629862
74MP0002067_abnormal_sensory_capabilities0.85065176
75MP0009764_decreased_sensitivity_to0.83123703
76MP0003937_abnormal_limbs/digits/tail_de0.81718863
77MP0002734_abnormal_mechanical_nocicepti0.81220212
78MP0005174_abnormal_tail_pigmentation0.81006912
79MP0002693_abnormal_pancreas_physiology0.80255310
80MP0002138_abnormal_hepatobiliary_system0.80013823
81MP0005195_abnormal_posterior_eye0.79324777
82MP0003938_abnormal_ear_development0.79042017
83MP0001501_abnormal_sleep_pattern0.78914422
84MP0003119_abnormal_digestive_system0.77873100
85MP0002752_abnormal_somatic_nervous0.77198542
86MP0003635_abnormal_synaptic_transmissio0.76986431
87MP0000538_abnormal_urinary_bladder0.75124510
88MP0010386_abnormal_urinary_bladder0.73727524
89MP0003136_yellow_coat_color0.73493083
90MP0001529_abnormal_vocalization0.72506064
91MP0004043_abnormal_pH_regulation0.71843751
92MP0003638_abnormal_response/metabolism_0.70205721
93MP0001188_hyperpigmentation0.69270692
94MP0003878_abnormal_ear_physiology0.68769910
95MP0005377_hearing/vestibular/ear_phenot0.68769910
96MP0001502_abnormal_circadian_rhythm0.68638310
97MP0002751_abnormal_autonomic_nervous0.68340263
98MP0001853_heart_inflammation0.67701284
99MP0002229_neurodegeneration0.65472746
100MP0002063_abnormal_learning/memory/cond0.65439492

Predicted human phenotypes

RankGene SetZ-score
1Cutaneous melanoma (HP:0012056)6.30671712
2Methylmalonic acidemia (HP:0002912)4.24485346
3Methylmalonic aciduria (HP:0012120)4.00955056
4Congenital stationary night blindness (HP:0007642)3.85073588
5Hyperglycinemia (HP:0002154)3.79616883
6Pancreatic cysts (HP:0001737)3.62059444
7Molar tooth sign on MRI (HP:0002419)3.37757399
8Abnormality of midbrain morphology (HP:0002418)3.37757399
9Congenital, generalized hypertrichosis (HP:0004540)3.25976783
10Pancreatic fibrosis (HP:0100732)3.23258071
11Nephronophthisis (HP:0000090)3.22605030
12True hermaphroditism (HP:0010459)3.13099529
13Meningioma (HP:0002858)3.08229678
14Pendular nystagmus (HP:0012043)2.75182680
15Abnormality of the renal medulla (HP:0100957)2.64724059
16Abolished electroretinogram (ERG) (HP:0000550)2.63520559
17Abnormality of the renal cortex (HP:0011035)2.56472256
18Type II lissencephaly (HP:0007260)2.52953455
19Acute necrotizing encephalopathy (HP:0006965)2.49119793
20Abnormal rod and cone electroretinograms (HP:0008323)2.48703963
21Absent rod-and cone-mediated responses on ERG (HP:0007688)2.48530261
22Mitochondrial inheritance (HP:0001427)2.44683383
23Progressive macrocephaly (HP:0004481)2.43180163
24Hypoplasia of the uterus (HP:0000013)2.37096394
25Cystic liver disease (HP:0006706)2.36867409
26Absent thumb (HP:0009777)2.35552593
27Ketosis (HP:0001946)2.35472682
28Abnormality of serine family amino acid metabolism (HP:0010894)2.34868507
29Abnormality of glycine metabolism (HP:0010895)2.34868507
30Agitation (HP:0000713)2.34648595
31Increased corneal curvature (HP:0100692)2.34186064
32Keratoconus (HP:0000563)2.34186064
33Hyperalaninemia (HP:0003348)2.33716473
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33716473
35Abnormality of alanine metabolism (HP:0010916)2.33716473
36Abnormality of the vitamin B12 metabolism (HP:0004341)2.33143054
37Abnormality of vitamin B metabolism (HP:0004340)2.32317210
38Attenuation of retinal blood vessels (HP:0007843)2.31827847
39Concave nail (HP:0001598)2.30049351
40Aplasia/hypoplasia of the uterus (HP:0008684)2.24277538
41IgG deficiency (HP:0004315)2.22467416
42Genetic anticipation (HP:0003743)2.21153874
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.20842921
44Increased CSF lactate (HP:0002490)2.19163226
453-Methylglutaconic aciduria (HP:0003535)2.18131700
46Sclerocornea (HP:0000647)2.16798150
47Acute encephalopathy (HP:0006846)2.16554806
48Abnormal mitochondria in muscle tissue (HP:0008316)2.15350161
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.14336308
50Progressive cerebellar ataxia (HP:0002073)2.14199613
51Medial flaring of the eyebrow (HP:0010747)2.12706416
52Renal cortical cysts (HP:0000803)2.10074112
53Abnormality of the renal collecting system (HP:0004742)2.09271008
54Chorioretinal atrophy (HP:0000533)2.06406359
55Chronic hepatic failure (HP:0100626)2.04428474
56Tubular atrophy (HP:0000092)2.04260786
57Dicarboxylic aciduria (HP:0003215)2.03597456
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.03597456
59Thyroiditis (HP:0100646)2.02495688
60Congenital sensorineural hearing impairment (HP:0008527)2.01976499
61Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99708227
62Polydipsia (HP:0001959)1.99667296
63Abnormal drinking behavior (HP:0030082)1.99667296
64Asplenia (HP:0001746)1.99266303
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.98615643
66Furrowed tongue (HP:0000221)1.97631610
67Abnormality of serum amino acid levels (HP:0003112)1.95295508
68Neoplasm of the lung (HP:0100526)1.94806998
69Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.94003156
70Short femoral neck (HP:0100864)1.92542298
71Absent/shortened dynein arms (HP:0200106)1.92259567
72Dynein arm defect of respiratory motile cilia (HP:0012255)1.92259567
73Abnormality of the middle phalanges of the toes (HP:0010183)1.91563689
74Abnormality of the proximal phalanges of the hand (HP:0009834)1.90526576
75Optic disc pallor (HP:0000543)1.89887474
76Decreased central vision (HP:0007663)1.88579422
77Lipid accumulation in hepatocytes (HP:0006561)1.88259534
78Hepatocellular necrosis (HP:0001404)1.86853613
79Increased hepatocellular lipid droplets (HP:0006565)1.86249138
80Stenosis of the external auditory canal (HP:0000402)1.84579049
81Abnormal ciliary motility (HP:0012262)1.83601159
82Abnormality of the phalanges of the 5th finger (HP:0004213)1.82500492
83Male pseudohermaphroditism (HP:0000037)1.82060605
84Short tibia (HP:0005736)1.81826539
85Tachypnea (HP:0002789)1.78758406
86Gaze-evoked nystagmus (HP:0000640)1.78269319
87Symphalangism affecting the phalanges of the hand (HP:0009773)1.78202262
88Abnormal number of erythroid precursors (HP:0012131)1.78035888
89Inability to walk (HP:0002540)1.77833731
90Abnormal respiratory motile cilium morphology (HP:0005938)1.75858875
91Abnormal respiratory epithelium morphology (HP:0012253)1.75858875
92Short hallux (HP:0010109)1.74197851
93Polyuria (HP:0000103)1.73813131
94Anencephaly (HP:0002323)1.73675028
95Pancytopenia (HP:0001876)1.72791301
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.71739589
97Progressive inability to walk (HP:0002505)1.71073348
98Melanoma (HP:0002861)1.70363953
99Aplasia/Hypoplasia of the hallux (HP:0008362)1.70182191
100Hepatic necrosis (HP:0002605)1.69834528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.55727852
2ADRBK23.33590847
3GRK13.07584854
4TLK12.96878426
5TXK2.77097846
6ZAK2.75741808
7WNK42.60720443
8TAOK32.58782314
9MAP4K22.37204392
10PINK12.28473816
11INSRR2.24692572
12FGFR22.17170302
13BMPR1B2.01158421
14BCKDK1.88810654
15NUAK11.84459515
16WNK31.73714922
17MAPK131.65698655
18ACVR1B1.43962903
19MAP3K131.36026919
20OXSR11.34575300
21STK391.29018921
22CASK1.20541309
23DYRK21.20405876
24TIE11.19140776
25IKBKB1.17590879
26MAP3K41.15554297
27STK161.12629189
28ADRBK11.11304008
29MUSK1.09323905
30KDR1.02450932
31MAP2K70.97676987
32PHKG10.95540837
33PHKG20.95540837
34MAPKAPK30.94538039
35PRKCG0.93441277
36DAPK20.93095826
37PRKCQ0.92264295
38CAMKK20.85815773
39MAP2K20.82003154
40PAK30.81930415
41ITK0.81077905
42PIK3CA0.79040705
43CSNK1G20.78469114
44TEC0.76846425
45VRK10.75541022
46GRK70.74384643
47CSNK1G30.74094888
48PRKCE0.73758359
49MAP4K10.72317785
50MKNK20.71747866
51KIT0.69102826
52NTRK20.68442799
53MARK10.67822325
54PLK20.67683390
55PASK0.65195627
56CAMKK10.65105002
57RPS6KA50.64246768
58VRK20.63615311
59MAP2K60.63399854
60CSNK1G10.62210877
61GRK60.61148182
62CHUK0.57568562
63PRKACA0.57377914
64NME10.56858178
65TNIK0.56588189
66CSNK1A10.56504667
67PLK10.55600839
68SGK10.55486326
69PLK40.55114920
70MAPK150.54216546
71SYK0.53525124
72TNK20.52478575
73PRKCI0.50749222
74TGFBR10.50340143
75PRKCZ0.49426576
76CAMK2A0.49255825
77OBSCN0.49246028
78STK110.48309395
79EPHB20.47271281
80CSNK1A1L0.46787188
81GRK50.46771196
82MAP3K140.46492493
83PLK30.45862179
84PRKCA0.44681754
85ERBB20.43642731
86ATR0.42931020
87LCK0.42722215
88PTK2B0.40911193
89MAP3K110.37823245
90SGK4940.37728702
91SGK2230.37728702
92CAMK10.36960777
93LYN0.36660962
94TESK20.36031037
95RPS6KA60.35415534
96MAPKAPK50.35166332
97NTRK30.33883036
98PKN10.32594291
99IGF1R0.32583119
100MAP3K70.32116566

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.04856675
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.92375818
3Phototransduction_Homo sapiens_hsa047442.77563360
4Sulfur metabolism_Homo sapiens_hsa009202.60826173
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.45186722
6Linoleic acid metabolism_Homo sapiens_hsa005912.26407746
7Parkinsons disease_Homo sapiens_hsa050122.24265780
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.18787844
9Nitrogen metabolism_Homo sapiens_hsa009102.06632248
10Nicotine addiction_Homo sapiens_hsa050331.98862853
11Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.88977983
12Tryptophan metabolism_Homo sapiens_hsa003801.88947129
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.76468374
14RNA polymerase_Homo sapiens_hsa030201.76160830
15Protein export_Homo sapiens_hsa030601.73498625
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72693887
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70589355
18Cardiac muscle contraction_Homo sapiens_hsa042601.69651996
19Caffeine metabolism_Homo sapiens_hsa002321.67365449
20Ribosome_Homo sapiens_hsa030101.66351813
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65748200
22Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.60372074
23Alzheimers disease_Homo sapiens_hsa050101.53919920
24Homologous recombination_Homo sapiens_hsa034401.52328940
25Primary immunodeficiency_Homo sapiens_hsa053401.51937682
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44928442
27Huntingtons disease_Homo sapiens_hsa050161.42836728
28Fanconi anemia pathway_Homo sapiens_hsa034601.37351345
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.36359816
30Peroxisome_Homo sapiens_hsa041461.35049244
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.31410760
32Butanoate metabolism_Homo sapiens_hsa006501.30045195
33Ether lipid metabolism_Homo sapiens_hsa005651.29262184
34Proteasome_Homo sapiens_hsa030501.27224568
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.25481831
36Chemical carcinogenesis_Homo sapiens_hsa052041.20697676
37Retinol metabolism_Homo sapiens_hsa008301.19905215
38Morphine addiction_Homo sapiens_hsa050321.19904709
39RNA degradation_Homo sapiens_hsa030181.17720663
40Taste transduction_Homo sapiens_hsa047421.15711187
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.14398355
42Sulfur relay system_Homo sapiens_hsa041221.13761724
43Basal transcription factors_Homo sapiens_hsa030221.12791394
44Collecting duct acid secretion_Homo sapiens_hsa049661.12464295
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06525831
46Glycerolipid metabolism_Homo sapiens_hsa005611.04245161
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03830254
48Selenocompound metabolism_Homo sapiens_hsa004501.03676097
49Fat digestion and absorption_Homo sapiens_hsa049751.01821406
50Vitamin digestion and absorption_Homo sapiens_hsa049771.01356477
51Olfactory transduction_Homo sapiens_hsa047400.99997553
52One carbon pool by folate_Homo sapiens_hsa006700.99917602
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98657075
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95919429
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.94271277
56Asthma_Homo sapiens_hsa053100.89011609
57Serotonergic synapse_Homo sapiens_hsa047260.88059685
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86295972
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85088871
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84573762
61Arachidonic acid metabolism_Homo sapiens_hsa005900.83961777
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83011150
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81062053
64Graft-versus-host disease_Homo sapiens_hsa053320.77341004
65GABAergic synapse_Homo sapiens_hsa047270.72312796
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.69168153
67Pyrimidine metabolism_Homo sapiens_hsa002400.68491306
68Glutamatergic synapse_Homo sapiens_hsa047240.68395310
69Fatty acid biosynthesis_Homo sapiens_hsa000610.68357620
70Insulin secretion_Homo sapiens_hsa049110.66726446
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65793216
72Propanoate metabolism_Homo sapiens_hsa006400.65435447
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64770902
74Type I diabetes mellitus_Homo sapiens_hsa049400.63003529
75Metabolic pathways_Homo sapiens_hsa011000.62674564
76Autoimmune thyroid disease_Homo sapiens_hsa053200.61972594
77Allograft rejection_Homo sapiens_hsa053300.61862204
78Purine metabolism_Homo sapiens_hsa002300.61771407
79Circadian entrainment_Homo sapiens_hsa047130.61685400
80Calcium signaling pathway_Homo sapiens_hsa040200.58045171
81Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55840599
82ABC transporters_Homo sapiens_hsa020100.51945292
83Mineral absorption_Homo sapiens_hsa049780.50798303
84Regulation of autophagy_Homo sapiens_hsa041400.50597204
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49921280
86Ovarian steroidogenesis_Homo sapiens_hsa049130.48503490
87Type II diabetes mellitus_Homo sapiens_hsa049300.48401681
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48101705
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46669970
90beta-Alanine metabolism_Homo sapiens_hsa004100.46294546
91Rheumatoid arthritis_Homo sapiens_hsa053230.44037159
92Hematopoietic cell lineage_Homo sapiens_hsa046400.42164208
93Fatty acid degradation_Homo sapiens_hsa000710.41521009
94Base excision repair_Homo sapiens_hsa034100.40642862
95Salivary secretion_Homo sapiens_hsa049700.40162763
96Basal cell carcinoma_Homo sapiens_hsa052170.38946442
97Nucleotide excision repair_Homo sapiens_hsa034200.35852629
98Dopaminergic synapse_Homo sapiens_hsa047280.32265884
99Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31754611
100Antigen processing and presentation_Homo sapiens_hsa046120.31089056

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