RBM17P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.96721405
2cellular response to electrical stimulus (GO:0071257)5.95101963
3cerebellar Purkinje cell differentiation (GO:0021702)5.59792177
4response to misfolded protein (GO:0051788)5.48021359
5endoderm formation (GO:0001706)5.06161668
6cell wall macromolecule catabolic process (GO:0016998)4.81617306
7cell wall macromolecule metabolic process (GO:0044036)4.80582562
8cytochrome complex assembly (GO:0017004)4.70201027
9positive regulation of gastrulation (GO:2000543)4.47532142
10somite rostral/caudal axis specification (GO:0032525)4.44058859
11glomerulus development (GO:0032835)4.43052651
12positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.33089774
13protein-cofactor linkage (GO:0018065)4.28133074
14detection of light stimulus involved in sensory perception (GO:0050962)4.08749132
15detection of light stimulus involved in visual perception (GO:0050908)4.08749132
16protein complex biogenesis (GO:0070271)4.06974690
17head development (GO:0060322)4.00489116
18regulation of centriole replication (GO:0046599)3.93604768
19positive regulation of amino acid transport (GO:0051957)3.81490919
20vagina development (GO:0060068)3.79870319
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.77176084
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.77176084
23nephron tubule morphogenesis (GO:0072078)3.76651513
24nephron epithelium morphogenesis (GO:0072088)3.76651513
25renal tubule morphogenesis (GO:0061333)3.69949629
26DNA double-strand break processing (GO:0000729)3.63229297
27regulation of sensory perception (GO:0051931)3.61864203
28regulation of sensory perception of pain (GO:0051930)3.61864203
29behavioral response to nicotine (GO:0035095)3.61094085
30kidney morphogenesis (GO:0060993)3.59927084
31sequestering of actin monomers (GO:0042989)3.58246294
32mitochondrial respiratory chain complex assembly (GO:0033108)3.56191164
33coenzyme catabolic process (GO:0009109)3.53958084
34negative regulation of translation, ncRNA-mediated (GO:0040033)3.43122798
35regulation of translation, ncRNA-mediated (GO:0045974)3.43122798
36negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.43122798
37protein neddylation (GO:0045116)3.42689840
38negative regulation of execution phase of apoptosis (GO:1900118)3.35743963
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.33776489
40urogenital system development (GO:0001655)3.31767431
41DNA damage response, detection of DNA damage (GO:0042769)3.30548429
42glutamate receptor signaling pathway (GO:0007215)3.29625563
43female genitalia development (GO:0030540)3.28446099
44respiratory chain complex IV assembly (GO:0008535)3.25546370
45spinal cord association neuron differentiation (GO:0021527)3.22529631
46arginine catabolic process (GO:0006527)3.22267580
47cornea development in camera-type eye (GO:0061303)3.17843863
48embryonic retina morphogenesis in camera-type eye (GO:0060059)3.17372438
49S-adenosylmethionine metabolic process (GO:0046500)3.16084221
50neuronal action potential (GO:0019228)3.15837331
51glycerophospholipid catabolic process (GO:0046475)3.13675898
52positive regulation of vesicle fusion (GO:0031340)3.05805634
53negative regulation of multicellular organism growth (GO:0040015)3.00822607
54phosphatidylserine acyl-chain remodeling (GO:0036150)3.00738565
55primitive streak formation (GO:0090009)3.00130554
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95494164
57dopamine transport (GO:0015872)2.89548353
58cell differentiation in spinal cord (GO:0021515)2.86808753
59UDP-N-acetylglucosamine metabolic process (GO:0006047)2.84816559
60cytoplasmic mRNA processing body assembly (GO:0033962)2.81259859
61regulation of respiratory system process (GO:0044065)2.78708726
62arginine metabolic process (GO:0006525)2.78560987
63negative regulation of protein localization to cell surface (GO:2000009)2.76953230
64positive regulation of embryonic development (GO:0040019)2.69874515
65protein import into peroxisome matrix (GO:0016558)2.69272662
66cellular ketone body metabolic process (GO:0046950)2.68698697
67serotonin receptor signaling pathway (GO:0007210)2.68678742
68anterograde synaptic vesicle transport (GO:0048490)2.64966599
69protein polyglutamylation (GO:0018095)2.63978591
70regulation of synaptic transmission, glutamatergic (GO:0051966)2.63285966
71phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.62984933
72uterus development (GO:0060065)2.60175900
73positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.57991501
74negative regulation of systemic arterial blood pressure (GO:0003085)2.57051075
75neuron fate specification (GO:0048665)2.55175291
76L-methionine salvage (GO:0071267)2.54044152
77L-methionine biosynthetic process (GO:0071265)2.54044152
78amino acid salvage (GO:0043102)2.54044152
79endocrine pancreas development (GO:0031018)2.51923834
80cerebellum development (GO:0021549)2.51903325
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.51602371
82mitochondrial respiratory chain complex I assembly (GO:0032981)2.51602371
83NADH dehydrogenase complex assembly (GO:0010257)2.51602371
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.49921060
85detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49839821
86cell differentiation in hindbrain (GO:0021533)2.47840068
87detection of calcium ion (GO:0005513)2.47798990
88cardiac right ventricle morphogenesis (GO:0003215)2.46392219
89misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.45741935
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45019343
91negative regulation of cell cycle arrest (GO:0071157)2.44644950
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.44643491
93anterograde axon cargo transport (GO:0008089)2.43119674
94reflex (GO:0060004)2.43061463
95ATP synthesis coupled proton transport (GO:0015986)2.42788421
96energy coupled proton transport, down electrochemical gradient (GO:0015985)2.42788421
97aldehyde catabolic process (GO:0046185)2.40073601
98ketone body metabolic process (GO:1902224)2.39301158
99phosphatidylinositol acyl-chain remodeling (GO:0036149)2.36636080
100pancreas development (GO:0031016)2.35831223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.92330905
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.53010075
3EZH2_22144423_ChIP-Seq_EOC_Human3.37916832
4ZNF274_21170338_ChIP-Seq_K562_Hela3.28275223
5GBX2_23144817_ChIP-Seq_PC3_Human2.87010448
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.79621971
7VDR_22108803_ChIP-Seq_LS180_Human2.65791565
8FUS_26573619_Chip-Seq_HEK293_Human2.50268877
9TAF15_26573619_Chip-Seq_HEK293_Human2.39679011
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.23463180
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22076564
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21242963
13EWS_26573619_Chip-Seq_HEK293_Human2.19166447
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12430307
15ER_23166858_ChIP-Seq_MCF-7_Human2.10197760
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02233950
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.00355857
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.99616176
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99212209
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93951450
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90977411
22P300_19829295_ChIP-Seq_ESCs_Human1.81142163
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80944613
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.80538691
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.77229467
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71633126
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.66986052
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.63593154
29IGF1R_20145208_ChIP-Seq_DFB_Human1.60735555
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.56802234
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.55166943
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54518793
33ETV2_25802403_ChIP-Seq_MESCs_Mouse1.52535087
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51540367
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.49015720
36MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46766741
37FOXA1_25329375_ChIP-Seq_VCAP_Human1.46583171
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46583171
39BCAT_22108803_ChIP-Seq_LS180_Human1.45477374
40REST_21632747_ChIP-Seq_MESCs_Mouse1.44738458
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.43496433
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41165981
43AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41165717
44TP53_22573176_ChIP-Seq_HFKS_Human1.40113482
45STAT3_23295773_ChIP-Seq_U87_Human1.39472150
46CBP_20019798_ChIP-Seq_JUKART_Human1.37361409
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37361409
48PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36681682
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.36264696
50SMAD4_21799915_ChIP-Seq_A2780_Human1.35702496
51AR_20517297_ChIP-Seq_VCAP_Human1.33329453
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32480764
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30563147
54TCF4_23295773_ChIP-Seq_U87_Human1.30544347
55NCOR_22424771_ChIP-Seq_293T_Human1.30270051
56RNF2_27304074_Chip-Seq_NSC_Mouse1.28175729
57MYC_18940864_ChIP-ChIP_HL60_Human1.27448931
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24433674
59EZH2_27304074_Chip-Seq_ESCs_Mouse1.21501355
60ELK1_19687146_ChIP-ChIP_HELA_Human1.20572479
61TCF4_22108803_ChIP-Seq_LS180_Human1.20167000
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19111527
63RUNX2_22187159_ChIP-Seq_PCA_Human1.16212867
64AR_25329375_ChIP-Seq_VCAP_Human1.16109111
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14303682
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14303682
67SMAD3_21741376_ChIP-Seq_HESCs_Human1.11875893
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.11271952
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.07623004
70UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06770880
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05360335
72SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04255007
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04088633
74CDX2_22108803_ChIP-Seq_LS180_Human1.03933849
75SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03642142
76CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03506605
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.02348078
78ERA_21632823_ChIP-Seq_H3396_Human1.01611803
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01513114
80SMAD3_21741376_ChIP-Seq_ESCs_Human0.99809898
81POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98496125
82FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97342214
83FLI1_21867929_ChIP-Seq_TH2_Mouse0.97069347
84AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96680425
85IRF1_19129219_ChIP-ChIP_H3396_Human0.96513845
86EZH2_27294783_Chip-Seq_NPCs_Mouse0.96411682
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96338200
88NFE2_27457419_Chip-Seq_LIVER_Mouse0.95945474
89P53_22387025_ChIP-Seq_ESCs_Mouse0.95854758
90SOX2_19829295_ChIP-Seq_ESCs_Human0.94283825
91NANOG_19829295_ChIP-Seq_ESCs_Human0.94283825
92EZH2_27294783_Chip-Seq_ESCs_Mouse0.93147393
93OCT4_20526341_ChIP-Seq_ESCs_Human0.92537577
94FOXH1_21741376_ChIP-Seq_EPCs_Human0.91778338
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.91686131
96TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90810397
97KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90473173
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90082768
99HOXB7_26014856_ChIP-Seq_BT474_Human0.89894423
100TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89875479

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ5.12561506
2MP0003787_abnormal_imprinting3.56473866
3MP0001968_abnormal_touch/_nociception3.24873180
4MP0003890_abnormal_embryonic-extraembry2.85305050
5MP0002736_abnormal_nociception_after2.59064311
6MP0006072_abnormal_retinal_apoptosis2.58880139
7MP0009046_muscle_twitch2.56109706
8MP0004043_abnormal_pH_regulation2.53279701
9MP0004147_increased_porphyrin_level2.39998536
10MP0003252_abnormal_bile_duct2.30615078
11MP0003195_calcinosis2.27554967
12MP0008877_abnormal_DNA_methylation2.25316449
13MP0002837_dystrophic_cardiac_calcinosis2.16368258
14MP0003646_muscle_fatigue2.08497184
15MP0003880_abnormal_central_pattern2.08392851
16MP0005645_abnormal_hypothalamus_physiol2.04683911
17MP0002557_abnormal_social/conspecific_i2.03322259
18MP0004924_abnormal_behavior2.00042909
19MP0005386_behavior/neurological_phenoty2.00042909
20MP0005253_abnormal_eye_physiology1.99969303
21MP0004885_abnormal_endolymph1.98374209
22MP0002272_abnormal_nervous_system1.91865454
23MP0003172_abnormal_lysosome_physiology1.78565090
24MP0004142_abnormal_muscle_tone1.75863600
25MP0002751_abnormal_autonomic_nervous1.74644208
26MP0003121_genomic_imprinting1.71552221
27MP0008995_early_reproductive_senescence1.69929513
28MP0000566_synostosis1.68348995
29MP0003136_yellow_coat_color1.65232633
30MP0002734_abnormal_mechanical_nocicepti1.63773258
31MP0000538_abnormal_urinary_bladder1.59744240
32MP0006292_abnormal_olfactory_placode1.53514724
33MP0001529_abnormal_vocalization1.50750455
34MP0006276_abnormal_autonomic_nervous1.49675011
35MP0002102_abnormal_ear_morphology1.47582743
36MP0000372_irregular_coat_pigmentation1.46745961
37MP0005551_abnormal_eye_electrophysiolog1.42109902
38MP0002735_abnormal_chemical_nociception1.42060350
39MP0000427_abnormal_hair_cycle1.39871391
40MP0003786_premature_aging1.37340313
41MP0002938_white_spotting1.36031353
42MP0001986_abnormal_taste_sensitivity1.35561147
43MP0009745_abnormal_behavioral_response1.35052292
44MP0008872_abnormal_physiological_respon1.34122582
45MP0004133_heterotaxia1.32324861
46MP0002572_abnormal_emotion/affect_behav1.32243835
47MP0002067_abnormal_sensory_capabilities1.32142169
48MP0002693_abnormal_pancreas_physiology1.30978994
49MP0001756_abnormal_urination1.29597800
50MP0005174_abnormal_tail_pigmentation1.26359626
51MP0003122_maternal_imprinting1.23402827
52MP0002909_abnormal_adrenal_gland1.21811883
53MP0005379_endocrine/exocrine_gland_phen1.21670997
54MP0000569_abnormal_digit_pigmentation1.20277315
55MP0008875_abnormal_xenobiotic_pharmacok1.17994584
56MP0010386_abnormal_urinary_bladder1.15882037
57MP0000647_abnormal_sebaceous_gland1.13331456
58MP0002063_abnormal_learning/memory/cond1.12855178
59MP0002733_abnormal_thermal_nociception1.12282651
60MP0001970_abnormal_pain_threshold1.10384356
61MP0003635_abnormal_synaptic_transmissio1.09985080
62MP0001944_abnormal_pancreas_morphology1.09588798
63MP0003186_abnormal_redox_activity1.09254626
64MP0003137_abnormal_impulse_conducting1.09168742
65MP0001299_abnormal_eye_distance/1.07939021
66MP0003011_delayed_dark_adaptation1.06902280
67MP0004019_abnormal_vitamin_homeostasis1.03190251
68MP0005083_abnormal_biliary_tract1.01021726
69MP0000955_abnormal_spinal_cord1.00450132
70MP0005423_abnormal_somatic_nervous0.99999128
71MP0002184_abnormal_innervation0.99252752
72MP0005646_abnormal_pituitary_gland0.98607214
73MP0005410_abnormal_fertilization0.98203142
74MP0005084_abnormal_gallbladder_morpholo0.97135679
75MP0001905_abnormal_dopamine_level0.93035710
76MP0000013_abnormal_adipose_tissue0.92448882
77MP0002139_abnormal_hepatobiliary_system0.91641736
78MP0001486_abnormal_startle_reflex0.90419149
79MP0003119_abnormal_digestive_system0.87217254
80MP0004742_abnormal_vestibular_system0.86222142
81MP0008775_abnormal_heart_ventricle0.86007112
82MP0002138_abnormal_hepatobiliary_system0.85346216
83MP0005377_hearing/vestibular/ear_phenot0.84641141
84MP0003878_abnormal_ear_physiology0.84641141
85MP0003718_maternal_effect0.83836080
86MP0005636_abnormal_mineral_homeostasis0.80988474
87MP0005391_vision/eye_phenotype0.80845414
88MP0008058_abnormal_DNA_repair0.80221015
89MP0003698_abnormal_male_reproductive0.80209690
90MP0005220_abnormal_exocrine_pancreas0.79678355
91MP0002064_seizures0.78191249
92MP0002095_abnormal_skin_pigmentation0.76257315
93MP0000778_abnormal_nervous_system0.75866232
94MP0002638_abnormal_pupillary_reflex0.75596454
95MP0000631_abnormal_neuroendocrine_gland0.75256692
96MP0001348_abnormal_lacrimal_gland0.75212440
97MP0005187_abnormal_penis_morphology0.74330209
98MP0002882_abnormal_neuron_morphology0.74217053
99MP0002653_abnormal_ependyma_morphology0.74147316
100MP0002229_neurodegeneration0.73797812

Predicted human phenotypes

RankGene SetZ-score
1Dysdiadochokinesis (HP:0002075)5.02472041
2Abnormal pancreas size (HP:0012094)4.86495124
3Genetic anticipation (HP:0003743)4.31371849
4Microretrognathia (HP:0000308)4.11277004
5Pancreatic fibrosis (HP:0100732)3.85290152
6Shawl scrotum (HP:0000049)3.77101853
7Decreased central vision (HP:0007663)3.51227368
8Horizontal nystagmus (HP:0000666)3.34839718
9Birth length less than 3rd percentile (HP:0003561)3.19386644
10Gaze-evoked nystagmus (HP:0000640)3.16983967
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.10166100
12Pancreatic cysts (HP:0001737)3.09094248
13Hyperventilation (HP:0002883)3.07775460
14Hypoalbuminemia (HP:0003073)3.00747951
15Abnormal albumin level (HP:0012116)3.00747951
16Pendular nystagmus (HP:0012043)3.00577644
17Abnormality of the renal cortex (HP:0011035)3.00122094
18Progressive cerebellar ataxia (HP:0002073)2.89664958
19True hermaphroditism (HP:0010459)2.88124559
20Esotropia (HP:0000565)2.87099009
21Abnormal rod and cone electroretinograms (HP:0008323)2.78947282
22Renal cortical cysts (HP:0000803)2.74806012
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.74574814
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.74574814
25Aplasia/hypoplasia of the uterus (HP:0008684)2.63404221
26Congenital stationary night blindness (HP:0007642)2.62757168
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.58116505
28Acute necrotizing encephalopathy (HP:0006965)2.56450883
293-Methylglutaconic aciduria (HP:0003535)2.54832955
30Lissencephaly (HP:0001339)2.54684666
31Methylmalonic acidemia (HP:0002912)2.51720822
32Chronic hepatic failure (HP:0100626)2.46779686
33Attenuation of retinal blood vessels (HP:0007843)2.46727392
34Dyskinesia (HP:0100660)2.46608135
35Hypoplasia of the uterus (HP:0000013)2.44392919
36Aplasia/Hypoplasia of the fovea (HP:0008060)2.42386112
37Hypoplasia of the fovea (HP:0007750)2.42386112
38Insulin-resistant diabetes mellitus (HP:0000831)2.41697042
39Pachygyria (HP:0001302)2.40034823
40Abnormality of midbrain morphology (HP:0002418)2.38569524
41Molar tooth sign on MRI (HP:0002419)2.38569524
42Prominent supraorbital ridges (HP:0000336)2.36441143
43Type II lissencephaly (HP:0007260)2.35595741
44Abnormal drinking behavior (HP:0030082)2.34501541
45Polydipsia (HP:0001959)2.34501541
46Tubular atrophy (HP:0000092)2.29986783
47Supernumerary spleens (HP:0009799)2.27233792
48Action tremor (HP:0002345)2.27023182
49Congenital hepatic fibrosis (HP:0002612)2.26662890
50Hypothermia (HP:0002045)2.25664282
51Medial flaring of the eyebrow (HP:0010747)2.24497361
52Ulnar claw (HP:0001178)2.24263783
53Hyperglycemia (HP:0003074)2.23448068
54Spastic paraparesis (HP:0002313)2.21017480
55Abnormal biliary tract physiology (HP:0012439)2.19134680
56Bile duct proliferation (HP:0001408)2.19134680
57Patellar aplasia (HP:0006443)2.17238188
58Methylmalonic aciduria (HP:0012120)2.16819760
59Increased corneal curvature (HP:0100692)2.16483327
60Keratoconus (HP:0000563)2.16483327
61Abnormal mitochondria in muscle tissue (HP:0008316)2.16447962
62Nephronophthisis (HP:0000090)2.15784779
63Progressive macrocephaly (HP:0004481)2.15739061
64Breast hypoplasia (HP:0003187)2.14320749
65Increased hepatocellular lipid droplets (HP:0006565)2.11358231
66Acute encephalopathy (HP:0006846)2.10418142
67Cystic liver disease (HP:0006706)2.09573255
68Abnormality of saccadic eye movements (HP:0000570)2.09280388
69Dry hair (HP:0011359)2.08486768
70Lipid accumulation in hepatocytes (HP:0006561)2.07348240
71Decreased circulating renin level (HP:0003351)2.06343009
72Congenital malformation of the right heart (HP:0011723)2.06245920
73Double outlet right ventricle (HP:0001719)2.06245920
74Hypomagnesemia (HP:0002917)2.04790676
75Abnormality of the renal medulla (HP:0100957)2.04111447
76Facial diplegia (HP:0001349)2.03274875
77Spinal muscular atrophy (HP:0007269)2.03211453
78Inability to walk (HP:0002540)2.03194873
79Abnormal respiratory motile cilium physiology (HP:0012261)2.03002166
80Mitochondrial inheritance (HP:0001427)2.01875057
81Optic disc pallor (HP:0000543)2.00302855
82Abnormality of the anterior horn cell (HP:0006802)1.99879324
83Degeneration of anterior horn cells (HP:0002398)1.99879324
84Cerebral edema (HP:0002181)1.99598242
85Tubulointerstitial nephritis (HP:0001970)1.98656270
86Aplasia/Hypoplasia of the patella (HP:0006498)1.98080036
87Ketoacidosis (HP:0001993)1.96726521
88Polyuria (HP:0000103)1.95131612
89Glycosuria (HP:0003076)1.94525837
90Abnormality of urine glucose concentration (HP:0011016)1.94525837
91Protruding tongue (HP:0010808)1.94279846
92Progressive inability to walk (HP:0002505)1.93752253
93Increased CSF lactate (HP:0002490)1.92266995
94Hypoplasia of the brainstem (HP:0002365)1.91712827
95Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91712827
96Tubulointerstitial abnormality (HP:0001969)1.91184774
97Abnormality of the fovea (HP:0000493)1.89227478
98Postural tremor (HP:0002174)1.88265616
99Pancreatic islet-cell hyperplasia (HP:0004510)1.85223178
100Chronic bronchitis (HP:0004469)1.84673743

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.14499488
2WNK43.79846512
3GRK13.01808721
4ADRBK22.98794151
5VRK22.35673085
6MAP4K22.31071427
7TNIK2.27962729
8BMPR1B2.17846814
9MAP3K42.10631487
10WNK31.98953889
11MARK11.98343053
12DAPK21.83687983
13INSRR1.80244100
14CASK1.79176795
15NUAK11.77546260
16WNK11.73803707
17EIF2AK31.69513724
18PINK11.69428151
19CAMKK21.57255078
20MAPK131.56782547
21BRSK21.55659233
22TIE11.51338555
23EPHA41.49150779
24MKNK11.47144911
25PRKCG1.40769698
26CSNK1G31.36521432
27MAP2K61.33156976
28PASK1.29113010
29PAK31.28184673
30TGFBR11.26806802
31CSNK1G21.24169080
32ACVR1B1.23196894
33CSNK1G11.19291139
34PRKCE1.18811434
35CCNB11.17812515
36CAMK2D1.16160961
37BMX1.14133939
38PHKG21.12144221
39PHKG11.12144221
40MST41.11404369
41VRK11.08477317
42TLK11.08114105
43CAMKK11.07683962
44TAOK31.07312729
45TNK21.06611848
46DYRK21.05835653
47ADRBK10.93541116
48MAPKAPK50.93538607
49PLK20.92790867
50UHMK10.91565637
51CSNK1A1L0.88735488
52ZAK0.88349867
53PIK3CA0.84660527
54ABL20.83973414
55NEK10.83583370
56TAF10.82756307
57PRKCH0.79266361
58STK110.79125922
59DDR20.78943244
60TRPM70.74019845
61CAMK2A0.71602369
62OXSR10.69919820
63MKNK20.69124053
64PRKCA0.62057042
65CDK30.60122392
66OBSCN0.59071577
67MAP2K70.57556278
68MAP2K40.56669242
69EPHB20.55578225
70PRKACA0.55103893
71PRKACB0.53833255
72FGFR20.53230585
73TYRO30.52363361
74RPS6KA50.50989627
75PRKCQ0.50726843
76STK390.50469536
77PTK60.50054706
78CSNK1A10.49777571
79DYRK1B0.49239056
80FES0.49099384
81PRKCZ0.48872268
82PLK30.48380877
83FER0.45107329
84CAMK1D0.44888117
85NTRK20.43550549
86MINK10.43003945
87PRKACG0.40069955
88MARK30.38382707
89SGK10.38060207
90PTK2B0.37174224
91SRPK10.37104546
92CAMK2B0.36588363
93ATM0.36372551
94PRKCB0.36098660
95GSK3A0.35798242
96PLK10.35672234
97CSNK1D0.33793088
98MAPK70.32275723
99IKBKB0.32096624
100SGK20.30302293

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034402.72341831
2Oxidative phosphorylation_Homo sapiens_hsa001902.67577730
3Linoleic acid metabolism_Homo sapiens_hsa005912.40110867
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.38333563
5Phototransduction_Homo sapiens_hsa047442.32328791
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.32185717
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24919255
8Taste transduction_Homo sapiens_hsa047422.22225552
9Propanoate metabolism_Homo sapiens_hsa006402.15253171
10Butanoate metabolism_Homo sapiens_hsa006502.12268898
11Nitrogen metabolism_Homo sapiens_hsa009102.06641544
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00497953
13RNA polymerase_Homo sapiens_hsa030201.98341601
14Parkinsons disease_Homo sapiens_hsa050121.94608894
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.83816596
16Fanconi anemia pathway_Homo sapiens_hsa034601.82157957
17Nicotine addiction_Homo sapiens_hsa050331.79232085
18Selenocompound metabolism_Homo sapiens_hsa004501.73067885
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.71638637
20Ribosome_Homo sapiens_hsa030101.67170187
21Long-term depression_Homo sapiens_hsa047301.65119442
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64927946
23ABC transporters_Homo sapiens_hsa020101.60641788
24Cardiac muscle contraction_Homo sapiens_hsa042601.59517734
25Tryptophan metabolism_Homo sapiens_hsa003801.57987798
26Glutamatergic synapse_Homo sapiens_hsa047241.54820378
27Arachidonic acid metabolism_Homo sapiens_hsa005901.52471650
28Arginine biosynthesis_Homo sapiens_hsa002201.50564568
29Asthma_Homo sapiens_hsa053101.39752754
30Sulfur metabolism_Homo sapiens_hsa009201.38990608
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36097189
32Huntingtons disease_Homo sapiens_hsa050161.33843192
33Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28955850
34Type I diabetes mellitus_Homo sapiens_hsa049401.28931275
35Ether lipid metabolism_Homo sapiens_hsa005651.27953079
36Peroxisome_Homo sapiens_hsa041461.27919478
37Collecting duct acid secretion_Homo sapiens_hsa049661.27494840
38Proteasome_Homo sapiens_hsa030501.26421508
39beta-Alanine metabolism_Homo sapiens_hsa004101.25707497
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14068547
41Insulin secretion_Homo sapiens_hsa049111.12732263
42Caffeine metabolism_Homo sapiens_hsa002321.09419549
43Protein export_Homo sapiens_hsa030601.09265842
44Serotonergic synapse_Homo sapiens_hsa047261.08502812
45Alzheimers disease_Homo sapiens_hsa050101.05906508
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05866014
47Non-homologous end-joining_Homo sapiens_hsa034501.05592157
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01782984
49Purine metabolism_Homo sapiens_hsa002300.99863759
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97834150
51Fatty acid elongation_Homo sapiens_hsa000620.97782536
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95881977
53Calcium signaling pathway_Homo sapiens_hsa040200.95796126
54Pyrimidine metabolism_Homo sapiens_hsa002400.94079947
55GABAergic synapse_Homo sapiens_hsa047270.92137716
56Regulation of autophagy_Homo sapiens_hsa041400.91477269
57Basal transcription factors_Homo sapiens_hsa030220.84542748
58Retinol metabolism_Homo sapiens_hsa008300.83089836
59Sphingolipid metabolism_Homo sapiens_hsa006000.82515559
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78250916
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.77534939
62RNA degradation_Homo sapiens_hsa030180.77285572
63Mismatch repair_Homo sapiens_hsa034300.75271819
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74942095
65Intestinal immune network for IgA production_Homo sapiens_hsa046720.74758577
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74057877
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73182306
68Ovarian steroidogenesis_Homo sapiens_hsa049130.71929180
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71564595
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.70148278
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.69923206
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69120192
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68974456
74Morphine addiction_Homo sapiens_hsa050320.67079155
75Metabolic pathways_Homo sapiens_hsa011000.65091194
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64842287
77Dopaminergic synapse_Homo sapiens_hsa047280.64194883
78Lysine degradation_Homo sapiens_hsa003100.62347176
79Olfactory transduction_Homo sapiens_hsa047400.61670069
80Base excision repair_Homo sapiens_hsa034100.59635488
81Histidine metabolism_Homo sapiens_hsa003400.55471968
82Salivary secretion_Homo sapiens_hsa049700.55126584
83Chemical carcinogenesis_Homo sapiens_hsa052040.53706046
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51068154
85Fatty acid degradation_Homo sapiens_hsa000710.50580928
86Nucleotide excision repair_Homo sapiens_hsa034200.49550894
87Fatty acid biosynthesis_Homo sapiens_hsa000610.48517329
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47789628
89One carbon pool by folate_Homo sapiens_hsa006700.47122102
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46850305
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45935713
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45536488
93Other glycan degradation_Homo sapiens_hsa005110.43766528
94Autoimmune thyroid disease_Homo sapiens_hsa053200.38852043
95Circadian entrainment_Homo sapiens_hsa047130.38648321
96Glycerolipid metabolism_Homo sapiens_hsa005610.37225958
97Mineral absorption_Homo sapiens_hsa049780.35332893
98Allograft rejection_Homo sapiens_hsa053300.34311394
99Arginine and proline metabolism_Homo sapiens_hsa003300.34133373
100DNA replication_Homo sapiens_hsa030300.33238720

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