RBBP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.73134251
2regulation of centriole replication (GO:0046599)4.59176781
3synapsis (GO:0007129)4.02460387
4non-recombinational repair (GO:0000726)3.97015546
5double-strand break repair via nonhomologous end joining (GO:0006303)3.97015546
6mitotic metaphase plate congression (GO:0007080)3.89992482
7ribosome assembly (GO:0042255)3.82068364
8protein localization to kinetochore (GO:0034501)3.74097279
9DNA replication checkpoint (GO:0000076)3.70085907
10sister chromatid cohesion (GO:0007062)3.69862630
11DNA ligation (GO:0006266)3.66461853
12kinetochore organization (GO:0051383)3.63166010
13establishment of viral latency (GO:0019043)3.58869415
14nuclear pore complex assembly (GO:0051292)3.58342093
15DNA strand elongation involved in DNA replication (GO:0006271)3.54036630
16mitotic chromosome condensation (GO:0007076)3.52727076
17metaphase plate congression (GO:0051310)3.47233141
18nuclear pore organization (GO:0006999)3.43242353
19CENP-A containing nucleosome assembly (GO:0034080)3.42635461
20telomere maintenance via semi-conservative replication (GO:0032201)3.41993045
21meiotic chromosome segregation (GO:0045132)3.40853403
22DNA strand elongation (GO:0022616)3.39815255
23regulation of mitotic sister chromatid separation (GO:0010965)3.37418959
24regulation of mitotic sister chromatid segregation (GO:0033047)3.37418959
25regulation of sister chromatid segregation (GO:0033045)3.37418959
26chromatin remodeling at centromere (GO:0031055)3.36301908
27telomere maintenance via recombination (GO:0000722)3.36235906
28protein localization to chromosome, centromeric region (GO:0071459)3.36127322
29DNA replication initiation (GO:0006270)3.34598804
30mitotic recombination (GO:0006312)3.32507874
31regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.32494862
32DNA unwinding involved in DNA replication (GO:0006268)3.32202780
33response to X-ray (GO:0010165)3.31039976
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.24660351
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24660351
36regulation of centrosome duplication (GO:0010824)3.23626153
37establishment of chromosome localization (GO:0051303)3.23319819
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.21067958
39mitotic nuclear envelope disassembly (GO:0007077)3.20462298
40DNA replication-independent nucleosome organization (GO:0034724)3.12945158
41DNA replication-independent nucleosome assembly (GO:0006336)3.12945158
42regulation of spindle organization (GO:0090224)3.12846082
43kinetochore assembly (GO:0051382)3.08742432
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.08325353
45* DNA double-strand break processing (GO:0000729)3.06703027
46DNA packaging (GO:0006323)3.06189864
47ribosomal small subunit assembly (GO:0000028)3.03323136
48cellular protein complex localization (GO:0034629)3.02357503
49postreplication repair (GO:0006301)3.02197900
50mitotic cell cycle (GO:0000278)3.00906094
51mitotic sister chromatid cohesion (GO:0007064)3.00752030
52IMP metabolic process (GO:0046040)3.00447730
53DNA topological change (GO:0006265)2.98373456
54pore complex assembly (GO:0046931)2.98329008
55* DNA catabolic process, exonucleolytic (GO:0000738)2.97346751
56membrane disassembly (GO:0030397)2.95356950
57nuclear envelope disassembly (GO:0051081)2.95356950
58attachment of spindle microtubules to kinetochore (GO:0008608)2.88681679
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85811636
60DNA replication-dependent nucleosome assembly (GO:0006335)2.83344715
61DNA replication-dependent nucleosome organization (GO:0034723)2.83344715
62histone exchange (GO:0043486)2.82435373
63maturation of SSU-rRNA (GO:0030490)2.81278734
64mitotic sister chromatid segregation (GO:0000070)2.75382145
65sister chromatid segregation (GO:0000819)2.74167996
66telomere maintenance via telomere lengthening (GO:0010833)2.70657652
67natural killer cell mediated immunity (GO:0002228)2.70601209
68natural killer cell mediated cytotoxicity (GO:0042267)2.70601209
69regulation of double-strand break repair via homologous recombination (GO:0010569)2.68164292
70regulation of mitotic spindle organization (GO:0060236)2.65874636
71chromosome segregation (GO:0007059)2.63860820
72formation of translation preinitiation complex (GO:0001731)2.62668555
73nucleotide-excision repair, DNA gap filling (GO:0006297)2.60084873
74spindle checkpoint (GO:0031577)2.58590975
75positive regulation of chromosome segregation (GO:0051984)2.58031059
76regulation of RIG-I signaling pathway (GO:0039535)2.53748799
77chromatin assembly or disassembly (GO:0006333)2.50572987
78protein localization to chromosome (GO:0034502)2.47981867
79regulation of chromosome segregation (GO:0051983)2.47472389
80mitotic G2/M transition checkpoint (GO:0044818)2.46109312
81telomere maintenance (GO:0000723)2.44916695
82regulation of mitotic metaphase/anaphase transition (GO:0030071)2.42584660
83DNA geometric change (GO:0032392)2.42479024
84telomere organization (GO:0032200)2.41391156
85DNA duplex unwinding (GO:0032508)2.40249797
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.38041015
87ATP-dependent chromatin remodeling (GO:0043044)2.37537788
88regulation of centrosome cycle (GO:0046605)2.36503527
89DNA synthesis involved in DNA repair (GO:0000731)2.35873740
90translesion synthesis (GO:0019985)2.35714221
91regulation of sister chromatid cohesion (GO:0007063)2.34416559
92positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.34379863
93positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.34379863
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.34379863
95ribosomal large subunit biogenesis (GO:0042273)2.33836375
96immunoglobulin mediated immune response (GO:0016064)2.33503967
97spindle assembly checkpoint (GO:0071173)2.32950441
98IMP biosynthetic process (GO:0006188)2.32503087
99purine nucleobase biosynthetic process (GO:0009113)2.32370384
100chromosome condensation (GO:0030261)2.31717593
101protein K6-linked ubiquitination (GO:0085020)2.31694841
102nucleobase biosynthetic process (GO:0046112)2.31653976
103mitotic spindle checkpoint (GO:0071174)2.31489410
104nuclear envelope organization (GO:0006998)2.30646113
105negative regulation of chromosome segregation (GO:0051985)2.30615777
106negative regulation of mitotic sister chromatid segregation (GO:0033048)2.30397304
107negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.30397304
108negative regulation of sister chromatid segregation (GO:0033046)2.30397304
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.30397304
110DNA conformation change (GO:0071103)2.30277626
111mismatch repair (GO:0006298)2.29971495
112histone-serine phosphorylation (GO:0035404)2.29944223
113regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.29470008
114regulation of mitotic spindle checkpoint (GO:1903504)2.29470008
115B cell mediated immunity (GO:0019724)2.28399514
116positive regulation of protein import into nucleus, translocation (GO:0033160)2.27832439
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.27084388
118regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.26008460
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.24875744
120mitotic spindle assembly checkpoint (GO:0007094)2.24733230
121regulation of histone H3-K9 methylation (GO:0051570)2.24574245
122NIK/NF-kappaB signaling (GO:0038061)2.23530249
123folic acid-containing compound biosynthetic process (GO:0009396)2.22337230
124regulation of DNA endoreduplication (GO:0032875)2.22265636

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.90167282
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.67510878
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.88464310
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.37198675
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.31457236
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.91487763
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.56531604
8AR_21909140_ChIP-Seq_LNCAP_Human2.52531259
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.42197311
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34416605
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.25549868
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22843673
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.22396748
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.07936059
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.00109631
16MYC_19030024_ChIP-ChIP_MESCs_Mouse1.99041007
17NELFA_20434984_ChIP-Seq_ESCs_Mouse1.97055278
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96464642
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.94797652
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.94296413
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.93638114
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91671847
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83264699
24ELK1_19687146_ChIP-ChIP_HELA_Human1.82368724
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.81821102
26VDR_23849224_ChIP-Seq_CD4+_Human1.76543899
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75250912
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.73744914
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.71138370
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68762001
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.68356450
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63571865
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58206568
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57303177
35* XRN2_22483619_ChIP-Seq_HELA_Human1.53141143
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53082118
37ETS1_20019798_ChIP-Seq_JURKAT_Human1.47895470
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46621727
39DCP1A_22483619_ChIP-Seq_HELA_Human1.46226274
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.45372946
41SPI1_23547873_ChIP-Seq_NB4_Human1.43876347
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43258324
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43247527
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.42533633
45FOXP3_21729870_ChIP-Seq_TREG_Human1.41098843
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39352967
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39308366
48* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.38927802
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.38273049
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37716916
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37051923
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34965315
53* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.34839349
54STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34084335
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33480166
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29425644
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.28690136
58MYB_26560356_Chip-Seq_TH2_Human1.28556494
59TTF2_22483619_ChIP-Seq_HELA_Human1.26799009
60BP1_19119308_ChIP-ChIP_Hs578T_Human1.24594560
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24430470
62MYC_22102868_ChIP-Seq_BL_Human1.23724499
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22581860
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20780276
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20759103
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.20703266
67* IRF8_27001747_Chip-Seq_BMDM_Mouse1.19662181
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19454436
69MYC_18940864_ChIP-ChIP_HL60_Human1.18501592
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17739110
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16159160
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15835285
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.15763749
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13681469
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.13354352
76MYB_26560356_Chip-Seq_TH1_Human1.11093557
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10653261
78* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10001794
79* GABP_19822575_ChIP-Seq_HepG2_Human1.09907598
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08921042
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08726417
82* EWS_26573619_Chip-Seq_HEK293_Human1.08132782
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07735645
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06899336
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.05499759
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03961041
87TFEB_21752829_ChIP-Seq_HELA_Human1.03735536
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02749353
89KDM5A_27292631_Chip-Seq_BREAST_Human1.02733248
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.99215251
91E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98584142
92NANOG_16153702_ChIP-ChIP_HESCs_Human0.97404612
93* FUS_26573619_Chip-Seq_HEK293_Human0.95967811
94HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94585009
95CIITA_25753668_ChIP-Seq_RAJI_Human0.94525470
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93992175
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.93697371
98CHD1_26751641_Chip-Seq_LNCaP_Human0.93533996
99HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93162783
100GATA1_22025678_ChIP-Seq_K562_Human0.93039470
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92649010
102STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91975765
103VDR_21846776_ChIP-Seq_THP-1_Human0.91617097
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90627145
105* MAF_26560356_Chip-Seq_TH1_Human0.90262687
106YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90063783
107SCL_19346495_ChIP-Seq_HPC-7_Human0.89774494
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89129038
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.87165447
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.86367526
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85365615
112SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.85186880
113SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.85186880
114RUNX1_22412390_ChIP-Seq_EML_Mouse0.84490715
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.83614843
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82608951
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82344464
118SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81723353
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81588348
120FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80531732
121GATA2_22383799_ChIP-Seq_G1ME_Mouse0.80188629
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79691609
123STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79192749
124POU5F1_16153702_ChIP-ChIP_HESCs_Human0.78737066
125RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77783852
126EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.77642785
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77297127
128ELF5_23300383_ChIP-Seq_T47D_Human0.75222760
129TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75148522
130CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72409187
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.72290508
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.72126803
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72126803
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72126803
135CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.69329718
136POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.69221276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.38171796
2MP0010094_abnormal_chromosome_stability3.24047626
3* MP0003693_abnormal_embryo_hatching3.20549174
4MP0003111_abnormal_nucleus_morphology2.79348672
5* MP0003077_abnormal_cell_cycle2.62990104
6MP0001835_abnormal_antigen_presentation2.43979426
7MP0004957_abnormal_blastocyst_morpholog2.43503277
8MP0008007_abnormal_cellular_replicative2.38100855
9MP0010234_abnormal_vibrissa_follicle2.23185487
10MP0009697_abnormal_copulation2.22767978
11MP0008058_abnormal_DNA_repair2.18402723
12MP0000579_abnormal_nail_morphology2.02172615
13MP0002396_abnormal_hematopoietic_system2.00422271
14MP0010307_abnormal_tumor_latency1.92013288
15MP0010352_gastrointestinal_tract_polyps1.88743291
16MP0009785_altered_susceptibility_to1.74108876
17MP0005397_hematopoietic_system_phenotyp1.67147615
18MP0001545_abnormal_hematopoietic_system1.67147615
19MP0000685_abnormal_immune_system1.65856446
20MP0002148_abnormal_hypersensitivity_rea1.64131843
21MP0003436_decreased_susceptibility_to1.63580356
22MP0002006_tumorigenesis1.63530393
23MP0003763_abnormal_thymus_physiology1.59157360
24MP0004808_abnormal_hematopoietic_stem1.55564262
25MP0002796_impaired_skin_barrier1.55351656
26MP0000490_abnormal_crypts_of1.53957356
27MP0003786_premature_aging1.52918860
28MP0005671_abnormal_response_to1.52874176
29MP0005076_abnormal_cell_differentiation1.50217403
30MP0000350_abnormal_cell_proliferation1.49966016
31MP0003890_abnormal_embryonic-extraembry1.47147300
32MP0002452_abnormal_antigen_presenting1.46262546
33MP0001800_abnormal_humoral_immune1.46050819
34MP0005000_abnormal_immune_tolerance1.45819523
35MP0008932_abnormal_embryonic_tissue1.45752853
36MP0009333_abnormal_splenocyte_physiolog1.44052198
37MP0002084_abnormal_developmental_patter1.40740187
38MP0009278_abnormal_bone_marrow1.39956693
39MP0002398_abnormal_bone_marrow1.36129407
40MP0002166_altered_tumor_susceptibility1.35937351
41MP0005387_immune_system_phenotype1.34686773
42MP0001790_abnormal_immune_system1.34686773
43MP0002085_abnormal_embryonic_tissue1.34187461
44MP0000383_abnormal_hair_follicle1.33524164
45MP0005025_abnormal_response_to1.33477094
46MP0000858_altered_metastatic_potential1.31981503
47MP0003724_increased_susceptibility_to1.31835726
48MP0003941_abnormal_skin_development1.31742237
49MP0003806_abnormal_nucleotide_metabolis1.30871088
50MP0002405_respiratory_system_inflammati1.30865739
51MP0001819_abnormal_immune_cell1.29405130
52MP0002420_abnormal_adaptive_immunity1.29156060
53MP0003448_altered_tumor_morphology1.29143235
54MP0002723_abnormal_immune_serum1.28524330
55MP0002419_abnormal_innate_immunity1.28221337
56MP0001853_heart_inflammation1.27820957
57MP0006054_spinal_hemorrhage1.24391959
58MP0005501_abnormal_skin_physiology1.24318737
59MP0002009_preneoplasia1.22424992
60MP0001293_anophthalmia1.21218388
61MP0003937_abnormal_limbs/digits/tail_de1.20617290
62MP0001929_abnormal_gametogenesis1.18544285
63MP0002254_reproductive_system_inflammat1.16171065
64MP0010155_abnormal_intestine_physiology1.15841229
65MP0000716_abnormal_immune_system1.14671573
66* MP0002019_abnormal_tumor_incidence1.14632007
67MP0004947_skin_inflammation1.13693970
68MP0002722_abnormal_immune_system1.13243949
69MP0003943_abnormal_hepatobiliary_system1.13206425
70MP0002877_abnormal_melanocyte_morpholog1.11805846
71MP0003453_abnormal_keratinocyte_physiol1.09492713
72MP0003123_paternal_imprinting1.08526145
73MP0000689_abnormal_spleen_morphology1.07946010
74MP0003566_abnormal_cell_adhesion1.07437560
75MP0002429_abnormal_blood_cell1.06787544
76MP0002697_abnormal_eye_size1.06597468
77* MP0001730_embryonic_growth_arrest1.06426325
78MP0008877_abnormal_DNA_methylation1.05828418
79MP0000703_abnormal_thymus_morphology1.05676366
80MP0000358_abnormal_cell_content/1.04899851
81MP0002163_abnormal_gland_morphology1.03989628
82MP0009672_abnormal_birth_weight1.03857285
83MP0001145_abnormal_male_reproductive1.02142394
84MP0000762_abnormal_tongue_morphology1.01931241
85MP0002160_abnormal_reproductive_system1.01057163
86MP0000313_abnormal_cell_death1.00628639
87MP0001346_abnormal_lacrimal_gland1.00256197
88MP0005023_abnormal_wound_healing0.99992909
89MP0002233_abnormal_nose_morphology0.99379416
90MP0001672_abnormal_embryogenesis/_devel0.98491211
91MP0005380_embryogenesis_phenotype0.98491211
92MP0000627_abnormal_mammary_gland0.97647235
93MP0003950_abnormal_plasma_membrane0.96481228
94MP0000653_abnormal_sex_gland0.95847901
95MP0001216_abnormal_epidermal_layer0.94210239
96MP0009053_abnormal_anal_canal0.94204396
97MP0000427_abnormal_hair_cycle0.93718660
98MP0000569_abnormal_digit_pigmentation0.92608332
99MP0001845_abnormal_inflammatory_respons0.92386673
100MP0000647_abnormal_sebaceous_gland0.91080111
101MP0006292_abnormal_olfactory_placode0.90216268
102MP0003984_embryonic_growth_retardation0.89704628
103MP0001286_abnormal_eye_development0.89698986
104MP0001873_stomach_inflammation0.89219376
105MP0003186_abnormal_redox_activity0.89099113
106MP0000537_abnormal_urethra_morphology0.88573276
107MP0002088_abnormal_embryonic_growth/wei0.88358822
108MP0006082_CNS_inflammation0.88081193
109MP0000377_abnormal_hair_follicle0.87960733
110MP0009703_decreased_birth_body0.87951045
111MP0005408_hypopigmentation0.87549949
112MP0001697_abnormal_embryo_size0.86833154
113MP0002132_abnormal_respiratory_system0.86765240
114MP0002098_abnormal_vibrissa_morphology0.85034076
115MP0001533_abnormal_skeleton_physiology0.85027185
116MP0001119_abnormal_female_reproductive0.83874844
117MP0002086_abnormal_extraembryonic_tissu0.83665374
118MP0002938_white_spotting0.83476752
119MP0006035_abnormal_mitochondrial_morpho0.82766577
120MP0000467_abnormal_esophagus_morphology0.82174191
121MP0005384_cellular_phenotype0.81279784
122MP0002111_abnormal_tail_morphology0.80568842
123MP0003718_maternal_effect0.79808921
124MP0003315_abnormal_perineum_morphology0.79740813
125MP0010678_abnormal_skin_adnexa0.79642239
126MP0001881_abnormal_mammary_gland0.79613802
127MP0010030_abnormal_orbit_morphology0.79399251
128MP0005621_abnormal_cell_physiology0.79397935
129MP0000465_gastrointestinal_hemorrhage0.79202731
130MP0003705_abnormal_hypodermis_morpholog0.77372109
131MP0003303_peritoneal_inflammation0.77113894
132MP0004185_abnormal_adipocyte_glucose0.76184428
133MP0003828_pulmonary_edema0.75804820
134MP0000428_abnormal_craniofacial_morphol0.75223792
135MP0002092_abnormal_eye_morphology0.75173234
136MP0003567_abnormal_fetal_cardiomyocyte0.74678947
137MP0002060_abnormal_skin_morphology0.74497169
138MP0002210_abnormal_sex_determination0.74249665
139MP0004197_abnormal_fetal_growth/weight/0.74234878
140MP0003755_abnormal_palate_morphology0.74196036
141MP0004782_abnormal_surfactant_physiolog0.73598610
142MP0002234_abnormal_pharynx_morphology0.73030170
143* MP0002080_prenatal_lethality0.72970551
144MP0004264_abnormal_extraembryonic_tissu0.72327607
145MP0010771_integument_phenotype0.69558278
146MP0005248_abnormal_Harderian_gland0.69164981
147MP0005389_reproductive_system_phenotype0.68272629
148MP0003699_abnormal_female_reproductive0.67725343
149MP0001191_abnormal_skin_condition0.67109079
150MP0003936_abnormal_reproductive_system0.67067769
151MP0000432_abnormal_head_morphology0.66945128
152MP0005395_other_phenotype0.65898127
153MP0004233_abnormal_muscle_weight0.63835131

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.28988791
2Chromsome breakage (HP:0040012)3.77909848
3Birth length less than 3rd percentile (HP:0003561)3.48806203
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.41893094
5Increased nuchal translucency (HP:0010880)3.37318165
6Nephroblastoma (Wilms tumor) (HP:0002667)3.35741195
7Reticulocytopenia (HP:0001896)3.17973100
8Embryonal renal neoplasm (HP:0011794)3.15625055
9Abnormality of chromosome stability (HP:0003220)3.04344819
10Rhabdomyosarcoma (HP:0002859)2.93933780
11Eczematoid dermatitis (HP:0000976)2.93050411
12Recurrent abscess formation (HP:0002722)2.91932074
13Retrobulbar optic neuritis (HP:0100654)2.86406333
14Optic neuritis (HP:0100653)2.86406333
15Myositis (HP:0100614)2.84826844
16Abnormal lung lobation (HP:0002101)2.79170504
17Orchitis (HP:0100796)2.78035749
18Abnormality of the carotid arteries (HP:0005344)2.66882896
19Onycholysis (HP:0001806)2.65689709
20Ependymoma (HP:0002888)2.62482482
21Recurrent bacterial skin infections (HP:0005406)2.60495272
22Prostate neoplasm (HP:0100787)2.60205841
23Abnormality of the preputium (HP:0100587)2.59207692
24Thrombocytosis (HP:0001894)2.52678639
25Glioma (HP:0009733)2.49213082
26Mediastinal lymphadenopathy (HP:0100721)2.46281900
27Abnormality of the labia minora (HP:0012880)2.44848475
2811 pairs of ribs (HP:0000878)2.44135539
29Abnormality of the fingertips (HP:0001211)2.41964851
30Proximal placement of thumb (HP:0009623)2.41846239
31Selective tooth agenesis (HP:0001592)2.41699971
32Irregular epiphyses (HP:0010582)2.40669115
33Myelodysplasia (HP:0002863)2.37359896
34Meckel diverticulum (HP:0002245)2.36646041
35Choanal atresia (HP:0000453)2.32308804
36Impulsivity (HP:0100710)2.29718721
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.28729109
38Breast hypoplasia (HP:0003187)2.27880024
39Abnormality of the astrocytes (HP:0100707)2.25000011
40Astrocytoma (HP:0009592)2.25000011
41Patellar aplasia (HP:0006443)2.24994473
42Abnormality of nail color (HP:0100643)2.24345833
43* Cafe-au-lait spot (HP:0000957)2.21633116
44Progressive external ophthalmoplegia (HP:0000590)2.20068507
45Lip pit (HP:0100267)2.19910546
46Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19747340
47Duodenal stenosis (HP:0100867)2.19090368
48Small intestinal stenosis (HP:0012848)2.19090368
49Abnormality of the ileum (HP:0001549)2.18853517
50Cortical dysplasia (HP:0002539)2.17429972
51Aplasia/Hypoplasia of the patella (HP:0006498)2.15551033
52Absent radius (HP:0003974)2.14994189
53Elevated erythrocyte sedimentation rate (HP:0003565)2.14651950
54Sparse eyelashes (HP:0000653)2.12593271
55Osteolytic defects of the hand bones (HP:0009699)2.12225621
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.12225621
57Recurrent viral infections (HP:0004429)2.12013185
58Poikiloderma (HP:0001029)2.10857866
59Acute myeloid leukemia (HP:0004808)2.09553512
60Abnormality of cells of the erythroid lineage (HP:0012130)2.09310806
61Abnormality of methionine metabolism (HP:0010901)2.08721644
62Neoplasm of the colon (HP:0100273)2.05784665
63Clubbing of toes (HP:0100760)2.05637723
64Pustule (HP:0200039)2.05202739
65Duplicated collecting system (HP:0000081)2.04438289
66Colon cancer (HP:0003003)2.03770334
67Multiple enchondromatosis (HP:0005701)2.03344626
68Abnormality of the prostate (HP:0008775)2.02904373
69Biliary tract neoplasm (HP:0100574)2.02530566
70Abnormal number of erythroid precursors (HP:0012131)2.01718096
71Facial cleft (HP:0002006)2.00806751
72Pili torti (HP:0003777)2.00518365
73Keratoconjunctivitis sicca (HP:0001097)2.00348265
74Autoimmune thrombocytopenia (HP:0001973)1.99738912
75Arteriovenous malformation (HP:0100026)1.99685456
76Cleft eyelid (HP:0000625)1.99021036
77Squamous cell carcinoma (HP:0002860)1.98928467
78Facial hemangioma (HP:0000329)1.98643749
79Carpal bone hypoplasia (HP:0001498)1.98577918
80Aplastic anemia (HP:0001915)1.98575570
81Agnosia (HP:0010524)1.98176575
82Aplasia involving forearm bones (HP:0009822)1.97918386
83Absent forearm bone (HP:0003953)1.97918386
84Recurrent fungal infections (HP:0002841)1.97833419
85Abnormality of the anterior horn cell (HP:0006802)1.97221366
86Degeneration of anterior horn cells (HP:0002398)1.97221366
87Horseshoe kidney (HP:0000085)1.93416179
88Embryonal neoplasm (HP:0002898)1.92878716
89Microvesicular hepatic steatosis (HP:0001414)1.90447962
90Breast carcinoma (HP:0003002)1.89975863
91Vasculitis (HP:0002633)1.89129005
92Periodontitis (HP:0000704)1.87991918
93Gastrointestinal carcinoma (HP:0002672)1.86794264
94Malignant gastrointestinal tract tumors (HP:0006749)1.86794264
95Keratoconjunctivitis (HP:0001096)1.86362834
96Ankyloglossia (HP:0010296)1.85930660
97Lymphoma (HP:0002665)1.85609925
98Papillary thyroid carcinoma (HP:0002895)1.85554865
99Abnormal spermatogenesis (HP:0008669)1.84331371
100* Ectopic kidney (HP:0000086)1.84134013
101Aseptic necrosis (HP:0010885)1.82795968
102Amaurosis fugax (HP:0100576)1.82726539
103Abnormality of the renal collecting system (HP:0004742)1.82466441
104Capillary hemangiomas (HP:0005306)1.81423307
105Missing ribs (HP:0000921)1.80818720
106IgM deficiency (HP:0002850)1.79496286
107Oral leukoplakia (HP:0002745)1.78587360
108Uterine neoplasm (HP:0010784)1.78330458
109Recurrent pneumonia (HP:0006532)1.77515785
110Septate vagina (HP:0001153)1.77057436
111Neoplasm of striated muscle (HP:0009728)1.76640950
112Microretrognathia (HP:0000308)1.76430087
113Pallor (HP:0000980)1.76269090
114Uterine leiomyosarcoma (HP:0002891)1.76183732
115Leiomyosarcoma (HP:0100243)1.76183732
116Spinal cord lesions (HP:0100561)1.75834465
117Syringomyelia (HP:0003396)1.75834465
118Recurrent bronchitis (HP:0002837)1.75305764
119Glossoptosis (HP:0000162)1.74522214
120Abnormality of T cell number (HP:0011839)1.74338789
121Blepharitis (HP:0000498)1.74132703
122Right ventricular cardiomyopathy (HP:0011663)1.73866832
123Autoimmune hemolytic anemia (HP:0001890)1.73855041
124Bone marrow hypocellularity (HP:0005528)1.73198564
125Rough bone trabeculation (HP:0100670)1.73124845
126Chronic otitis media (HP:0000389)1.72514744
127Aplasia cutis congenita (HP:0001057)1.72475976
128Hypoplastic labia majora (HP:0000059)1.71650685
129Median cleft lip (HP:0000161)1.71346154
130Deep philtrum (HP:0002002)1.70857285
131Stillbirth (HP:0003826)1.69934340
132Neoplasm of the small intestine (HP:0100833)1.69789441
133Chronic obstructive pulmonary disease (HP:0006510)1.69769798
134Obstructive lung disease (HP:0006536)1.69769798
135Ovarian neoplasm (HP:0100615)1.69515323
136Stenosis of the external auditory canal (HP:0000402)1.69229413
137Short thumb (HP:0009778)1.68910097
138Fragile nails (HP:0001808)1.68669764
139Absent thumb (HP:0009777)1.67108360
140IgG deficiency (HP:0004315)1.66691291
141Milia (HP:0001056)1.66017541
142Tracheoesophageal fistula (HP:0002575)1.65118888
143Abnormality of placental membranes (HP:0011409)1.65113169
144Amniotic constriction ring (HP:0009775)1.65113169
145Abnormality of T cells (HP:0002843)1.64909687
146Entropion (HP:0000621)1.64855388
147Abnormality of the duodenum (HP:0002246)1.64565144
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64438152
149Atresia of the external auditory canal (HP:0000413)1.64105507
150Deviation of the thumb (HP:0009603)1.63865143
151T lymphocytopenia (HP:0005403)1.63687309
152Transitional cell carcinoma of the bladder (HP:0006740)1.63497469
153Cellulitis (HP:0100658)1.63068728
154Small epiphyses (HP:0010585)1.62893268
155Medulloblastoma (HP:0002885)1.62419120
156Sloping forehead (HP:0000340)1.61510492
157IgA deficiency (HP:0002720)1.61142528
158Central scotoma (HP:0000603)1.60378981
159Abnormalities of placenta or umbilical cord (HP:0001194)1.60326466
160Dyschromatopsia (HP:0007641)1.60187899
161Abnormality of T cell physiology (HP:0011840)1.59426232
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.59219908
163Abnormality of the umbilical cord (HP:0010881)1.59033097
164Leukopenia (HP:0001882)1.58162048
165Premature graying of hair (HP:0002216)1.58064205
166Triphalangeal thumb (HP:0001199)1.57268916
167Leukocytosis (HP:0001974)1.55779620
168Flat capital femoral epiphysis (HP:0003370)1.55644098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.49259748
2WEE12.89094864
3BUB12.44420504
4PLK42.43472859
5PNCK2.37548475
6NEK22.35053593
7MST1R2.28807538
8MAP3K142.27924122
9RPS6KA42.21340510
10EIF2AK12.18656634
11ACVR1B2.11402389
12BRSK21.96160268
13STK101.82752148
14TRIM281.79933431
15VRK21.77461931
16SRPK11.74968586
17TAF11.68985842
18TTK1.68813016
19STK31.66375379
20DYRK31.65225671
21AURKB1.63310136
22TYK21.60216574
23CDK121.57642282
24NME21.56611570
25MST41.53384191
26ZAK1.52471313
27PIM21.51468511
28IKBKB1.50481089
29PBK1.50021799
30NUAK11.44166807
31EIF2AK21.43639294
32PLK11.43455930
33MAP4K11.43171528
34STK41.42494686
35* ATR1.42290261
36TGFBR11.41924826
37JAK31.40763430
38MKNK11.39034440
39CHUK1.38428753
40VRK11.35103203
41CDK71.35080754
42EIF2AK31.33990106
43IRAK41.33705135
44PIM11.31305779
45RPS6KB21.30792958
46MET1.28949632
47STK161.27027491
48TXK1.25102910
49TBK11.19536986
50ERBB31.18130192
51NEK91.17555270
52MAP3K31.14459131
53PLK31.13872448
54STK241.12599207
55IKBKE1.11060880
56BLK1.10518764
57PASK1.08811882
58CDK41.06909647
59IRAK31.05678314
60TRPM71.04557301
61BRSK11.02258645
62MAP3K81.01863553
63CDK61.01208556
64CHEK20.98272935
65MKNK20.97305113
66CCNB10.96627575
67BCR0.95076253
68BRD40.93501334
69MELK0.93443321
70TLK10.93048578
71LATS10.91238422
72STK38L0.90421932
73TEC0.88726632
74CDK80.86671841
75CHEK10.85986693
76TESK10.85776849
77EPHA20.81568512
78TSSK60.80577989
79TNIK0.77721050
80* ATM0.77675676
81LRRK20.77481449
82MAP3K120.77349117
83ZAP700.76845319
84BRAF0.74235140
85MAP2K30.70280372
86BTK0.70203044
87EEF2K0.68607627
88KIT0.66727321
89LATS20.66540262
90AURKA0.65680264
91RPS6KA50.63943220
92YES10.63375430
93NLK0.59122011
94ERBB40.58945679
95STK390.57564743
96FGFR10.56815533
97SMG10.56177787
98CAMK1G0.52580095
99* CDK20.50331217
100MUSK0.50137061
101PLK20.49492993
102BMPR20.48957969
103MAP3K20.48752928
104CDK30.48650024
105MAPKAPK30.48647053
106CSNK2A20.48277036
107CSNK2A10.47814635
108CLK10.47531927
109MAPKAPK20.47013426
110CDK90.46562794
111LYN0.46168559
112BMPR1B0.44658573
113JAK10.44521362
114MAP3K50.44453731
115NEK10.43678535
116CSNK1E0.43112182
117ALK0.43078347
118MAP3K100.41591516
119PAK40.41458644
120MARK30.41316570
121NME10.41068657
122PRKCI0.40561189
123SIK30.39241229
124SCYL20.38777230
125* CDK10.38521880
126TGFBR20.37081398
127CSK0.36198629
128DYRK1B0.35272277
129* PRKDC0.34613916
130MAP3K90.34349499
131RAF10.32552110
132CSNK1G10.30693365
133NEK60.30023975
134CDK180.29495806
135KSR10.28565029
136PDK20.26575934
137RPS6KB10.25887309

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.70577784
2Mismatch repair_Homo sapiens_hsa034302.86757272
3Cell cycle_Homo sapiens_hsa041102.48181125
4Homologous recombination_Homo sapiens_hsa034402.46806905
5Base excision repair_Homo sapiens_hsa034102.40039250
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39146280
7RNA transport_Homo sapiens_hsa030132.07626196
8Spliceosome_Homo sapiens_hsa030402.05099192
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01649398
10One carbon pool by folate_Homo sapiens_hsa006701.93173961
11Fanconi anemia pathway_Homo sapiens_hsa034601.89573174
12Nucleotide excision repair_Homo sapiens_hsa034201.89193070
13p53 signaling pathway_Homo sapiens_hsa041151.88377202
14Ribosome_Homo sapiens_hsa030101.88002674
15RNA polymerase_Homo sapiens_hsa030201.86926543
16Proteasome_Homo sapiens_hsa030501.80100616
17Graft-versus-host disease_Homo sapiens_hsa053321.79762281
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.78069828
19Non-homologous end-joining_Homo sapiens_hsa034501.77840829
20Allograft rejection_Homo sapiens_hsa053301.74615235
21Herpes simplex infection_Homo sapiens_hsa051681.74386964
22Leishmaniasis_Homo sapiens_hsa051401.63736168
23Legionellosis_Homo sapiens_hsa051341.61528401
24Pyrimidine metabolism_Homo sapiens_hsa002401.58356744
25Antigen processing and presentation_Homo sapiens_hsa046121.54955356
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.50368520
27Measles_Homo sapiens_hsa051621.50061261
28RNA degradation_Homo sapiens_hsa030181.48075789
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47286739
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.41206796
31Basal transcription factors_Homo sapiens_hsa030221.40521400
32Oocyte meiosis_Homo sapiens_hsa041141.39532058
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.33444478
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32028365
35Systemic lupus erythematosus_Homo sapiens_hsa053221.25536986
36Influenza A_Homo sapiens_hsa051641.23710486
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23043360
38Epstein-Barr virus infection_Homo sapiens_hsa051691.20884332
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19741463
40Small cell lung cancer_Homo sapiens_hsa052221.19311900
41Apoptosis_Homo sapiens_hsa042101.10508638
42Viral carcinogenesis_Homo sapiens_hsa052031.10150682
43mRNA surveillance pathway_Homo sapiens_hsa030151.09837574
44Steroid biosynthesis_Homo sapiens_hsa001001.09411636
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.09324969
46TNF signaling pathway_Homo sapiens_hsa046681.05283897
47Primary immunodeficiency_Homo sapiens_hsa053401.04940659
48Hematopoietic cell lineage_Homo sapiens_hsa046401.03271340
49Malaria_Homo sapiens_hsa051441.02780068
50Toxoplasmosis_Homo sapiens_hsa051451.02466362
51Hepatitis B_Homo sapiens_hsa051610.99934619
52Propanoate metabolism_Homo sapiens_hsa006400.99067991
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97340212
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96163407
55HTLV-I infection_Homo sapiens_hsa051660.95830969
56Autoimmune thyroid disease_Homo sapiens_hsa053200.95158759
57Fatty acid elongation_Homo sapiens_hsa000620.94086421
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.93236285
59MicroRNAs in cancer_Homo sapiens_hsa052060.93036523
60Pyruvate metabolism_Homo sapiens_hsa006200.92257777
61Viral myocarditis_Homo sapiens_hsa054160.90921274
62Asthma_Homo sapiens_hsa053100.90810954
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90582403
64Pertussis_Homo sapiens_hsa051330.87671038
65Osteoclast differentiation_Homo sapiens_hsa043800.86908417
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84245274
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82401375
68Shigellosis_Homo sapiens_hsa051310.81608646
69Biosynthesis of amino acids_Homo sapiens_hsa012300.78740045
70Type I diabetes mellitus_Homo sapiens_hsa049400.78271450
71Lysine degradation_Homo sapiens_hsa003100.78153680
72N-Glycan biosynthesis_Homo sapiens_hsa005100.74772956
73Tuberculosis_Homo sapiens_hsa051520.73570106
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68117507
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67839533
76Purine metabolism_Homo sapiens_hsa002300.66838365
77TGF-beta signaling pathway_Homo sapiens_hsa043500.66651143
78Chronic myeloid leukemia_Homo sapiens_hsa052200.65523403
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63069037
80B cell receptor signaling pathway_Homo sapiens_hsa046620.62949198
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60532790
82Thyroid cancer_Homo sapiens_hsa052160.60212417
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60018128
84Carbon metabolism_Homo sapiens_hsa012000.59212503
85Glutathione metabolism_Homo sapiens_hsa004800.58058629
86Adherens junction_Homo sapiens_hsa045200.57522619
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55349276
88Salmonella infection_Homo sapiens_hsa051320.54794491
89Hepatitis C_Homo sapiens_hsa051600.54778171
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54532197
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54464791
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.53803701
93Prostate cancer_Homo sapiens_hsa052150.53730923
94Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52921993
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52780972
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51754253
97Pancreatic cancer_Homo sapiens_hsa052120.51096261
98Bladder cancer_Homo sapiens_hsa052190.49914969
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49369733
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48429328
101T cell receptor signaling pathway_Homo sapiens_hsa046600.47369927
102Colorectal cancer_Homo sapiens_hsa052100.46252604
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45498686
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45452019
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.45211604
106Protein export_Homo sapiens_hsa030600.44472841
107Staphylococcus aureus infection_Homo sapiens_hsa051500.43957724
108Huntingtons disease_Homo sapiens_hsa050160.43181850
109Notch signaling pathway_Homo sapiens_hsa043300.42615990
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42524332
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.40742654
112Acute myeloid leukemia_Homo sapiens_hsa052210.40265279
113Melanoma_Homo sapiens_hsa052180.39760813
114Vitamin B6 metabolism_Homo sapiens_hsa007500.39264408
115ECM-receptor interaction_Homo sapiens_hsa045120.37783271
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37288947
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36709503
118FoxO signaling pathway_Homo sapiens_hsa040680.36481676
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35708631
120Selenocompound metabolism_Homo sapiens_hsa004500.35294561
121Folate biosynthesis_Homo sapiens_hsa007900.35256956
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.35194675
123Rheumatoid arthritis_Homo sapiens_hsa053230.35112798
124Hippo signaling pathway_Homo sapiens_hsa043900.34823232
125Pathways in cancer_Homo sapiens_hsa052000.34402599
126Wnt signaling pathway_Homo sapiens_hsa043100.33706192
127Pentose phosphate pathway_Homo sapiens_hsa000300.33497631
128Alcoholism_Homo sapiens_hsa050340.31728255
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.30118343
130Metabolic pathways_Homo sapiens_hsa011000.27984720
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27398461
132Basal cell carcinoma_Homo sapiens_hsa052170.27128727
133Fatty acid metabolism_Homo sapiens_hsa012120.24467081
134Tight junction_Homo sapiens_hsa045300.24341207
135Proteoglycans in cancer_Homo sapiens_hsa052050.22289908
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18797030
137Parkinsons disease_Homo sapiens_hsa050120.18330638
138Sphingolipid metabolism_Homo sapiens_hsa006000.18066108
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17407211
140Endometrial cancer_Homo sapiens_hsa052130.16820398
141beta-Alanine metabolism_Homo sapiens_hsa004100.16783282
142Hedgehog signaling pathway_Homo sapiens_hsa043400.11898306
143Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.11003005

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