RBAK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)7.33348830
2telomere maintenance via telomerase (GO:0007004)6.56095414
3nuclear pore organization (GO:0006999)6.29961747
4pore complex assembly (GO:0046931)5.21072995
5regulation of centriole replication (GO:0046599)4.95453802
6centriole replication (GO:0007099)4.86760288
7RNA-dependent DNA replication (GO:0006278)4.83505319
8histone H3-K9 methylation (GO:0051567)4.74981238
9spindle assembly involved in mitosis (GO:0090307)4.62369328
10microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.53979544
11mast cell activation (GO:0045576)4.52326070
12regulation of RNA export from nucleus (GO:0046831)4.48349917
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.43509470
14centriole assembly (GO:0098534)4.35794839
15monoubiquitinated protein deubiquitination (GO:0035520)4.34785930
16histone H3-K9 modification (GO:0061647)4.28865292
17negative regulation of cAMP-mediated signaling (GO:0043951)4.27870765
18cytoplasmic mRNA processing body assembly (GO:0033962)4.26967599
19telomere maintenance via semi-conservative replication (GO:0032201)4.14228774
20tRNA methylation (GO:0030488)4.12714397
21regulation of helicase activity (GO:0051095)3.99789066
22DNA strand renaturation (GO:0000733)3.82024417
23regulation of centrosome duplication (GO:0010824)3.81513805
24regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.73708731
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.69203062
26positive regulation of gamma-delta T cell activation (GO:0046645)3.67067728
27regulation of centrosome cycle (GO:0046605)3.66482304
28nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.63825951
29telomere maintenance via recombination (GO:0000722)3.61648801
30nucleotide-excision repair, DNA gap filling (GO:0006297)3.60419972
31regulation of non-canonical Wnt signaling pathway (GO:2000050)3.60020765
32ribosome assembly (GO:0042255)3.55963568
33negative regulation of DNA-dependent DNA replication (GO:2000104)3.55596990
34regulation of nucleobase-containing compound transport (GO:0032239)3.53136112
35negative regulation of mast cell activation (GO:0033004)3.50336375
36histone H3-K4 trimethylation (GO:0080182)3.48815469
37DNA duplex unwinding (GO:0032508)3.47824014
38necroptotic process (GO:0070266)3.46535769
39DNA geometric change (GO:0032392)3.45038152
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.37933355
41regulation of type B pancreatic cell apoptotic process (GO:2000674)3.36837174
42positive regulation of T cell apoptotic process (GO:0070234)3.35753484
43bone remodeling (GO:0046849)3.32019067
44mitotic recombination (GO:0006312)3.31987686
45energy homeostasis (GO:0097009)3.29629148
46negative regulation of DNA repair (GO:0045738)3.29078273
47negative regulation of fibroblast apoptotic process (GO:2000270)3.26292884
48DNA damage induced protein phosphorylation (GO:0006975)3.25353952
49negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.23841716
50telomere maintenance via telomere lengthening (GO:0010833)3.21764381
51interkinetic nuclear migration (GO:0022027)3.21056940
52positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.20075752
53peptidyl-lysine trimethylation (GO:0018023)3.19559207
54mitochondrial DNA replication (GO:0006264)3.18231799
55NLS-bearing protein import into nucleus (GO:0006607)3.16247789
56histone mRNA catabolic process (GO:0071044)3.15577495
57positive regulation of mitotic sister chromatid separation (GO:1901970)3.14354706
58positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.14354706
59positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.14354706
60embryonic body morphogenesis (GO:0010172)3.10733884
61replicative senescence (GO:0090399)3.09158342
62DNA replication checkpoint (GO:0000076)3.05858033
63regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05815586
64response to pheromone (GO:0019236)3.05376001
65mesenchymal cell differentiation involved in renal system development (GO:2001012)3.01380510
66mesenchymal cell differentiation involved in kidney development (GO:0072161)3.01380510
67histone H3-K9 demethylation (GO:0033169)3.01122990
68mitotic G2/M transition checkpoint (GO:0044818)3.01045595
69definitive hemopoiesis (GO:0060216)2.97900577
70regulation of establishment of cell polarity (GO:2000114)2.93885185
71DNA demethylation (GO:0080111)2.93463522
72protein localization to kinetochore (GO:0034501)2.93335880
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92361776
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92361776
75regulation of telomere maintenance (GO:0032204)2.90960082
76negative regulation of translation, ncRNA-mediated (GO:0040033)2.88705574
77regulation of translation, ncRNA-mediated (GO:0045974)2.88705574
78negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88705574
79sister chromatid segregation (GO:0000819)2.88485856
80prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.87584519
81mitotic nuclear envelope disassembly (GO:0007077)2.86130804
82protein localization to chromosome, centromeric region (GO:0071459)2.85405731
83membrane disassembly (GO:0030397)2.82748291
84nuclear envelope disassembly (GO:0051081)2.82748291
85mitotic chromosome condensation (GO:0007076)2.81834925
86non-recombinational repair (GO:0000726)2.80657218
87double-strand break repair via nonhomologous end joining (GO:0006303)2.80657218
88phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.80096829
89cell differentiation involved in metanephros development (GO:0072202)2.79948496
90regulation of sister chromatid segregation (GO:0033045)2.78313763
91regulation of mitotic sister chromatid separation (GO:0010965)2.78313763
92regulation of mitotic sister chromatid segregation (GO:0033047)2.78313763
93regulation of histone H3-K27 methylation (GO:0061085)2.77481926
94regulation of DNA endoreduplication (GO:0032875)2.76570058
95keratinocyte development (GO:0003334)2.75747275
96histone H3-K36 demethylation (GO:0070544)2.75280476
97regulation of sister chromatid cohesion (GO:0007063)2.74457337
98mitotic G2 DNA damage checkpoint (GO:0007095)2.73737302
99mRNA splice site selection (GO:0006376)2.72500503
100negative regulation of neurotransmitter secretion (GO:0046929)2.71934879
101body morphogenesis (GO:0010171)2.71616073
102replication fork processing (GO:0031297)2.71420119
103DNA conformation change (GO:0071103)2.70895529
104regulation of chromatin silencing (GO:0031935)2.70411196
105negative regulation of mRNA metabolic process (GO:1903312)2.69588818
106positive regulation of chromosome segregation (GO:0051984)2.68656764
107histone lysine demethylation (GO:0070076)2.68273925
108gastrulation with mouth forming second (GO:0001702)2.67681347
109photoreceptor cell differentiation (GO:0046530)2.67193050
110eye photoreceptor cell differentiation (GO:0001754)2.67193050
111spindle checkpoint (GO:0031577)2.65775095
112regulation of telomere maintenance via telomerase (GO:0032210)2.64948042
113heterochromatin organization (GO:0070828)2.64554802
114negative regulation of sister chromatid segregation (GO:0033046)2.63463346
115negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.63463346
116negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.63463346
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.63463346
118negative regulation of mitotic sister chromatid separation (GO:2000816)2.63463346
119toxin transport (GO:1901998)2.62032718
120intra-S DNA damage checkpoint (GO:0031573)2.61317036
121regulation of Rac protein signal transduction (GO:0035020)2.61152503
122N-terminal protein amino acid acetylation (GO:0006474)2.60543269
123COPII vesicle coating (GO:0048208)2.59637289
124mitotic spindle checkpoint (GO:0071174)2.58322631
125regulation of gamma-delta T cell activation (GO:0046643)2.58134679
126negative regulation of chromosome segregation (GO:0051985)2.57271634
127regulation of transforming growth factor beta2 production (GO:0032909)2.56920969
128oogenesis (GO:0048477)2.56455129
129purinergic nucleotide receptor signaling pathway (GO:0035590)2.56365506
130mitochondrial DNA metabolic process (GO:0032042)2.55934132
131mitotic cytokinesis (GO:0000281)2.55880228
132DNA strand elongation involved in DNA replication (GO:0006271)2.55842864
133response to interferon-alpha (GO:0035455)2.55794221
134L-alpha-amino acid transmembrane transport (GO:1902475)2.55727391
135DNA topological change (GO:0006265)2.55673477
136segment specification (GO:0007379)2.54303403
137positive regulation of lymphocyte apoptotic process (GO:0070230)2.54073033
138mRNA transport (GO:0051028)2.52888281
139DNA unwinding involved in DNA replication (GO:0006268)2.51765574
140DNA strand elongation (GO:0022616)2.51360662
141negative regulation of mRNA processing (GO:0050686)2.50458398
142spliceosomal tri-snRNP complex assembly (GO:0000244)2.49868517
143bone trabecula formation (GO:0060346)2.49113848
144regulation of glucokinase activity (GO:0033131)2.48662369
145regulation of hexokinase activity (GO:1903299)2.48662369
146regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48543551
147regulation of histone H3-K9 methylation (GO:0051570)2.48148917
148spindle assembly checkpoint (GO:0071173)2.48138130
149mitotic spindle assembly checkpoint (GO:0007094)2.48123254
150negative regulation of granulocyte differentiation (GO:0030853)2.48081585
151histone H2B ubiquitination (GO:0033523)2.47000743
152otic vesicle formation (GO:0030916)2.45202443
153negative regulation of keratinocyte proliferation (GO:0010839)2.45129329
154regulation of chromosome segregation (GO:0051983)2.44584259
155cytoskeleton-dependent cytokinesis (GO:0061640)2.44391054
156peptidyl-lysine methylation (GO:0018022)2.44190732
157pre-miRNA processing (GO:0031054)2.43785968
158regulation of B cell receptor signaling pathway (GO:0050855)2.41550494
159telomere maintenance (GO:0000723)2.41236008
160snRNA processing (GO:0016180)2.38554225
161gene silencing by RNA (GO:0031047)2.38244915
162cell proliferation in forebrain (GO:0021846)2.37230473
163histone lysine methylation (GO:0034968)2.35252337
164dosage compensation (GO:0007549)2.34979839
165megakaryocyte development (GO:0035855)2.34749975
166regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.33734352
167attachment of spindle microtubules to kinetochore (GO:0008608)2.33049844
168mitotic sister chromatid cohesion (GO:0007064)2.32944936
169regulation of DNA damage checkpoint (GO:2000001)2.32619320
170telomere organization (GO:0032200)2.32018087
171nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.29363737
172negative regulation of DNA recombination (GO:0045910)2.28571274
173regulation of gamma-delta T cell differentiation (GO:0045586)2.28043360
174maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.25082978
175DNA dealkylation (GO:0035510)2.24780124
176histone H3-K4 methylation (GO:0051568)2.23070356
177transcription-coupled nucleotide-excision repair (GO:0006283)2.22893860
178alternative mRNA splicing, via spliceosome (GO:0000380)2.22208213
179regulation of necroptotic process (GO:0060544)2.20585071
180embryonic hemopoiesis (GO:0035162)2.20250427
181spindle assembly (GO:0051225)2.19914452
182sister chromatid cohesion (GO:0007062)2.19299128
183histone demethylation (GO:0016577)2.19130186
184negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.18965284
185T cell differentiation (GO:0030217)2.18616873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.36982915
2E2F7_22180533_ChIP-Seq_HELA_Human5.22804019
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.12255232
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.99234681
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.80346251
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.13770526
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.09305722
8SCL_19346495_ChIP-Seq_HPC-7_Human2.93555292
9GBX2_23144817_ChIP-Seq_PC3_Human2.58500686
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52385562
11AR_21909140_ChIP-Seq_LNCAP_Human2.47649772
12VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.27547775
13RUNX1_17652178_ChIP-ChIP_JURKAT_Human2.18204289
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13548275
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11448474
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05482607
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.04670735
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.03833353
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.01640278
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99940781
21ELK1_19687146_ChIP-ChIP_HELA_Human1.97797782
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96327398
23MYC_22102868_ChIP-Seq_BL_Human1.93540037
24* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92976749
25PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86620394
26GATA1_22025678_ChIP-Seq_K562_Human1.84509218
27RUNX1_26923725_Chip-Seq_HPCs_Mouse1.84054630
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.81915137
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.80576811
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78239447
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.75098300
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.72987825
33FUS_26573619_Chip-Seq_HEK293_Human1.68144859
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58765936
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58336258
36SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.52912020
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52091671
38MYB_26560356_Chip-Seq_TH2_Human1.51503348
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50501576
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50204976
41RNF2_27304074_Chip-Seq_NSC_Mouse1.48604137
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48552115
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47897935
44FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.46641047
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.46250882
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46157042
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43982687
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41726580
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39695792
50AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38918557
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.37184123
52CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36577606
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.35380747
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.35365449
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.33563626
56GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.32417253
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30350935
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28982914
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28365600
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.27732374
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.25587125
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.24139069
63CIITA_25753668_ChIP-Seq_RAJI_Human1.23510564
64AR_21572438_ChIP-Seq_LNCaP_Human1.23037676
65CHD1_26751641_Chip-Seq_LNCaP_Human1.22314414
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22224150
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22185664
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21932036
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21502410
70SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20476788
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18934823
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18452491
73MYC_18555785_ChIP-Seq_MESCs_Mouse1.17731631
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17116280
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15403763
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15068206
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14127908
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13887257
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12480070
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12473086
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11903097
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11903097
83TP53_16413492_ChIP-PET_HCT116_Human1.11843092
84MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09141240
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08598547
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06919065
87NANOG_16153702_ChIP-ChIP_HESCs_Human1.06499239
88FOXM1_23109430_ChIP-Seq_U2OS_Human1.05986092
89ESR1_21235772_ChIP-Seq_MCF-7_Human1.04346059
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04237521
91TCF7_22412390_ChIP-Seq_EML_Mouse1.04090931
92* STAT3_23295773_ChIP-Seq_U87_Human1.03189726
93FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.03160052
94ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01346380
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.00417572
96ER_23166858_ChIP-Seq_MCF-7_Human1.00140917
97PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99997624
98EWS_26573619_Chip-Seq_HEK293_Human0.99230635
99NELFA_20434984_ChIP-Seq_ESCs_Mouse0.99161291
100CMYC_18555785_Chip-Seq_ESCs_Mouse0.98771276
101ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98736900
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97341743
103TCF4_18268006_ChIP-ChIP_LS174T_Human0.96453849
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95288902
105EZH2_27294783_Chip-Seq_NPCs_Mouse0.95236524
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.94980513
107YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94911114
108CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94850861
109PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94586985
110ISL1_27105846_Chip-Seq_CPCs_Mouse0.94371817
111MAF_26560356_Chip-Seq_TH1_Human0.93873596
112YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93597167
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93385194
114IGF1R_20145208_ChIP-Seq_DFB_Human0.92984850
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92837296
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92687735
117MYB_26560356_Chip-Seq_TH1_Human0.92640098
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92518485
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.91612456
120BRD4_25478319_ChIP-Seq_HGPS_Human0.91317478
121FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91172036
122FOXO3_23340844_ChIP-Seq_DLD1_Human0.90658523
123SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90507663
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.90486049
125PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90289627
126DROSHA_22980978_ChIP-Seq_HELA_Human0.89639559
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.89140550
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.89117901
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88968955
130SMAD3_21741376_ChIP-Seq_EPCs_Human0.88037961
131SMAD4_21799915_ChIP-Seq_A2780_Human0.87299054
132TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86150280
133* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86008384
134TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.85804622
135TBX3_20139965_ChIP-Seq_MESCs_Mouse0.85733432
136STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85626660
137HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85356046
138P300_18555785_Chip-Seq_ESCs_Mouse0.85282310
139SOX9_26525672_Chip-Seq_HEART_Mouse0.85236957
140EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84419045
141P300_19829295_ChIP-Seq_ESCs_Human0.83562312
142* SOX2_16153702_ChIP-ChIP_HESCs_Human0.83265797
143SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.81661794
144KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80620589
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80446548
146CDX2_20551321_ChIP-Seq_CACO-2_Human0.78817582
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.77458753
148GATA2_21666600_ChIP-Seq_HMVEC_Human0.76958132
149ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76423130
150MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76212871
151P53_22127205_ChIP-Seq_FIBROBLAST_Human0.75896497
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.74578181
153PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74564610
154SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.74200519
155SUZ12_18555785_Chip-Seq_ESCs_Mouse0.74180401
156STAT3_18555785_Chip-Seq_ESCs_Mouse0.73867307
157SPI1_23547873_ChIP-Seq_NB4_Human0.72835249
158SPI1_23127762_ChIP-Seq_K562_Human0.72830412

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia5.84982830
2MP0003787_abnormal_imprinting4.22771603
3MP0000569_abnormal_digit_pigmentation3.68443934
4MP0006292_abnormal_olfactory_placode3.52496712
5MP0003890_abnormal_embryonic-extraembry3.30245329
6MP0003136_yellow_coat_color2.99670346
7MP0004957_abnormal_blastocyst_morpholog2.90769217
8MP0000015_abnormal_ear_pigmentation2.90082558
9MP0003693_abnormal_embryo_hatching2.71111623
10MP0008057_abnormal_DNA_replication2.51293362
11MP0005409_darkened_coat_color2.50326914
12MP0002166_altered_tumor_susceptibility2.48516011
13MP0009697_abnormal_copulation2.21907383
14MP0003121_genomic_imprinting2.08508257
15MP0001188_hyperpigmentation2.07912435
16MP0006054_spinal_hemorrhage2.07469355
17MP0010307_abnormal_tumor_latency2.03505360
18MP0002095_abnormal_skin_pigmentation1.98170180
19MP0002006_tumorigenesis1.90236885
20MP0010234_abnormal_vibrissa_follicle1.86890897
21MP0002638_abnormal_pupillary_reflex1.82961693
22MP0004808_abnormal_hematopoietic_stem1.81495996
23MP0010678_abnormal_skin_adnexa1.75135090
24MP0008932_abnormal_embryonic_tissue1.73895260
25MP0000428_abnormal_craniofacial_morphol1.72821407
26MP0000678_abnormal_parathyroid_gland1.72625625
27MP0004134_abnormal_chest_morphology1.71573234
28MP0005174_abnormal_tail_pigmentation1.70343828
29MP0002075_abnormal_coat/hair_pigmentati1.68870786
30MP0001986_abnormal_taste_sensitivity1.67520767
31MP0002396_abnormal_hematopoietic_system1.67287898
32MP0004133_heterotaxia1.66787561
33MP0001730_embryonic_growth_arrest1.66548847
34MP0000383_abnormal_hair_follicle1.65652087
35MP0003763_abnormal_thymus_physiology1.64762841
36MP0003111_abnormal_nucleus_morphology1.62812332
37MP0005171_absent_coat_pigmentation1.62387719
38MP0001697_abnormal_embryo_size1.61721852
39MP0004233_abnormal_muscle_weight1.61554779
40MP0004197_abnormal_fetal_growth/weight/1.59766709
41MP0000350_abnormal_cell_proliferation1.59228654
42MP0001672_abnormal_embryogenesis/_devel1.57174923
43MP0005380_embryogenesis_phenotype1.57174923
44MP0008995_early_reproductive_senescence1.56024293
45MP0002088_abnormal_embryonic_growth/wei1.54702481
46MP0003984_embryonic_growth_retardation1.53672082
47MP0005645_abnormal_hypothalamus_physiol1.53554915
48MP0002928_abnormal_bile_duct1.52097286
49MP0000516_abnormal_urinary_system1.51600458
50MP0005367_renal/urinary_system_phenotyp1.51600458
51MP0009672_abnormal_birth_weight1.51449049
52MP0002084_abnormal_developmental_patter1.50513273
53MP0002086_abnormal_extraembryonic_tissu1.49830376
54MP0000537_abnormal_urethra_morphology1.48688373
55MP0001186_pigmentation_phenotype1.44966855
56MP0009703_decreased_birth_body1.42247916
57MP0005076_abnormal_cell_differentiation1.41460478
58MP0005075_abnormal_melanosome_morpholog1.41030530
59MP0002938_white_spotting1.38984180
60MP0002132_abnormal_respiratory_system1.38698098
61MP0000427_abnormal_hair_cycle1.37682509
62MP0008058_abnormal_DNA_repair1.36643823
63MP0003868_abnormal_feces_composition1.35908935
64MP0004185_abnormal_adipocyte_glucose1.34194123
65MP0003221_abnormal_cardiomyocyte_apopto1.33358824
66MP0010386_abnormal_urinary_bladder1.30240372
67MP0002233_abnormal_nose_morphology1.29850694
68MP0000432_abnormal_head_morphology1.27953657
69MP0002085_abnormal_embryonic_tissue1.25957788
70MP0008007_abnormal_cellular_replicative1.23877253
71MP0001915_intracranial_hemorrhage1.22967660
72MP0003123_paternal_imprinting1.21909763
73MP0000377_abnormal_hair_follicle1.19997305
74MP0000372_irregular_coat_pigmentation1.19653969
75MP0008877_abnormal_DNA_methylation1.16935538
76MP0001177_atelectasis1.15846905
77MP0002177_abnormal_outer_ear1.13205620
78MP0010094_abnormal_chromosome_stability1.12926728
79MP0000371_diluted_coat_color1.12744513
80MP0002080_prenatal_lethality1.12081210
81MP0002697_abnormal_eye_size1.10189289
82MP0001835_abnormal_antigen_presentation1.09681506
83MP0001286_abnormal_eye_development1.08735713
84MP0000778_abnormal_nervous_system1.08044970
85MP0005187_abnormal_penis_morphology1.07840433
86MP0003755_abnormal_palate_morphology1.07636650
87MP0002089_abnormal_postnatal_growth/wei1.07460125
88MP0001348_abnormal_lacrimal_gland1.06561932
89MP0001293_anophthalmia1.05498400
90MP0002877_abnormal_melanocyte_morpholog1.05289449
91MP0003786_premature_aging1.03655183
92MP0002163_abnormal_gland_morphology1.02206399
93MP0005257_abnormal_intraocular_pressure1.01933035
94MP0000647_abnormal_sebaceous_gland1.01721302
95MP0002111_abnormal_tail_morphology1.01231840
96MP0002398_abnormal_bone_marrow1.00494993
97MP0002116_abnormal_craniofacial_bone0.98514494
98MP0002098_abnormal_vibrissa_morphology0.98510219
99MP0010352_gastrointestinal_tract_polyps0.97657831
100MP0000703_abnormal_thymus_morphology0.96143002
101MP0001270_distended_abdomen0.95730465
102MP0001299_abnormal_eye_distance/0.94324117
103MP0000313_abnormal_cell_death0.93758397
104MP0000579_abnormal_nail_morphology0.92727830
105MP0001800_abnormal_humoral_immune0.92325335
106MP0000465_gastrointestinal_hemorrhage0.92163564
107MP0009250_abnormal_appendicular_skeleto0.91861786
108MP0003941_abnormal_skin_development0.91816698
109MP0005671_abnormal_response_to0.89570642
110MP0010630_abnormal_cardiac_muscle0.89540668
111MP0002254_reproductive_system_inflammat0.89287793
112MP0000681_abnormal_thyroid_gland0.89118022
113MP0008789_abnormal_olfactory_epithelium0.87799676
114MP0003385_abnormal_body_wall0.87772876
115MP0003705_abnormal_hypodermis_morpholog0.87723690
116MP0005248_abnormal_Harderian_gland0.87378282
117MP0005646_abnormal_pituitary_gland0.87227480
118MP0000627_abnormal_mammary_gland0.86389169
119MP0000490_abnormal_crypts_of0.85976808
120MP0004084_abnormal_cardiac_muscle0.85895727
121MP0001502_abnormal_circadian_rhythm0.84948565
122MP0003861_abnormal_nervous_system0.84225804
123MP0000689_abnormal_spleen_morphology0.83853662
124MP0002092_abnormal_eye_morphology0.83586309
125MP0002796_impaired_skin_barrier0.83302100
126MP0005408_hypopigmentation0.82633974
127MP0004147_increased_porphyrin_level0.82561904
128MP0001216_abnormal_epidermal_layer0.82458240
129MP0003935_abnormal_craniofacial_develop0.82037154
130MP0000631_abnormal_neuroendocrine_gland0.82019769
131MP0000462_abnormal_digestive_system0.80340006
132MP0002932_abnormal_joint_morphology0.79541372
133MP0001119_abnormal_female_reproductive0.78999326
134MP0003942_abnormal_urinary_system0.78745892
135MP0003937_abnormal_limbs/digits/tail_de0.77687545
136MP0004264_abnormal_extraembryonic_tissu0.77673625
137MP0001879_abnormal_lymphatic_vessel0.77651985
138MP0002722_abnormal_immune_system0.76448803
139MP0002081_perinatal_lethality0.76354771
140MP0005499_abnormal_olfactory_system0.75985201
141MP0005394_taste/olfaction_phenotype0.75985201
142MP0009053_abnormal_anal_canal0.75832389
143MP0003077_abnormal_cell_cycle0.75645863
144MP0000049_abnormal_middle_ear0.75584393
145MP0005621_abnormal_cell_physiology0.75577290
146MP0002249_abnormal_larynx_morphology0.73386371
147MP0000716_abnormal_immune_system0.73385115
148MP0003567_abnormal_fetal_cardiomyocyte0.72569696
149MP0003122_maternal_imprinting0.71438539
150MP0004145_abnormal_muscle_electrophysio0.71035894
151MP0001784_abnormal_fluid_regulation0.70438626
152MP0002148_abnormal_hypersensitivity_rea0.70400419
153MP0002114_abnormal_axial_skeleton0.70258673
154MP0002277_abnormal_respiratory_mucosa0.70103791
155MP0000762_abnormal_tongue_morphology0.69656921
156MP0003936_abnormal_reproductive_system0.68757166
157MP0005503_abnormal_tendon_morphology0.68561530
158MP0005220_abnormal_exocrine_pancreas0.68392297
159MP0000534_abnormal_ureter_morphology0.68319523
160MP0006072_abnormal_retinal_apoptosis0.68197689
161MP0000613_abnormal_salivary_gland0.67870285
162MP0002420_abnormal_adaptive_immunity0.67832666
163MP0001191_abnormal_skin_condition0.67231171
164MP0005508_abnormal_skeleton_morphology0.66805668
165MP0001175_abnormal_lung_morphology0.66702969
166MP0003943_abnormal_hepatobiliary_system0.66639932
167MP0002109_abnormal_limb_morphology0.66524225
168MP0005384_cellular_phenotype0.65705290
169MP0000266_abnormal_heart_morphology0.65453271
170MP0001340_abnormal_eyelid_morphology0.64846497

Predicted human phenotypes

RankGene SetZ-score
1Lip pit (HP:0100267)6.17633021
2Papillary thyroid carcinoma (HP:0002895)4.66946428
3Facial hemangioma (HP:0000329)4.31811509
4Pancreatic cysts (HP:0001737)4.17172565
5Capillary hemangiomas (HP:0005306)4.07917739
6Myositis (HP:0100614)3.94583709
7Neoplasm of the oral cavity (HP:0100649)3.81837461
8Broad palm (HP:0001169)3.46394082
9Abnormality of chromosome stability (HP:0003220)3.43051580
10Curly hair (HP:0002212)3.37997013
11Nephroblastoma (Wilms tumor) (HP:0002667)3.36023577
12Abnormality of the fovea (HP:0000493)3.32776270
13Posterior subcapsular cataract (HP:0007787)3.25490648
14Medulloblastoma (HP:0002885)3.23973865
15Spinal cord lesions (HP:0100561)3.22069855
16Syringomyelia (HP:0003396)3.22069855
17Heterotopia (HP:0002282)3.18732306
18Embryonal renal neoplasm (HP:0011794)3.17484287
19Thyroid carcinoma (HP:0002890)3.13441314
20Hepatoblastoma (HP:0002884)3.07739417
21Aplasia/Hypoplasia of the fovea (HP:0008060)3.06294153
22Hypoplasia of the fovea (HP:0007750)3.06294153
23Deep philtrum (HP:0002002)3.05717192
24Transitional cell carcinoma of the bladder (HP:0006740)3.00446470
25Acute myeloid leukemia (HP:0004808)2.96682861
26Bifid tongue (HP:0010297)2.91482524
27Rhabdomyosarcoma (HP:0002859)2.91326310
28Subacute progressive viral hepatitis (HP:0006572)2.89367954
29Broad alveolar ridges (HP:0000187)2.84747392
30Bladder carcinoma (HP:0002862)2.84312548
31Bladder neoplasm (HP:0009725)2.84312548
32Volvulus (HP:0002580)2.81160157
33Thrombocytosis (HP:0001894)2.74979295
34Ankyloglossia (HP:0010296)2.74959459
35Wide nose (HP:0000445)2.72532526
36Increased number of teeth (HP:0011069)2.71418161
37Neoplasm of the adrenal cortex (HP:0100641)2.71128176
38Absent frontal sinuses (HP:0002688)2.58202286
39Pustule (HP:0200039)2.57988286
40Gastrointestinal carcinoma (HP:0002672)2.57700731
41Malignant gastrointestinal tract tumors (HP:0006749)2.57700731
42Molar tooth sign on MRI (HP:0002419)2.57183307
43Abnormality of midbrain morphology (HP:0002418)2.57183307
44Increased nuchal translucency (HP:0010880)2.54956911
45Decreased skull ossification (HP:0004331)2.53205103
46Cystic liver disease (HP:0006706)2.52663214
47Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.50272837
48Neoplasm of the small intestine (HP:0100833)2.48065294
49Amaurosis fugax (HP:0100576)2.47755960
50Microretrognathia (HP:0000308)2.46137197
51Colon cancer (HP:0003003)2.45735250
52Acute lymphatic leukemia (HP:0006721)2.45499548
53Protruding tongue (HP:0010808)2.44978888
54Breast carcinoma (HP:0003002)2.44344331
55Breech presentation (HP:0001623)2.43274564
56Glioma (HP:0009733)2.41688060
57Esophageal atresia (HP:0002032)2.41150205
58Tinnitus (HP:0000360)2.40711782
59Abnormality of the diencephalon (HP:0010662)2.39676055
60Aqueductal stenosis (HP:0002410)2.38079619
61Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.36068447
62Macroorchidism (HP:0000053)2.32245823
63Long clavicles (HP:0000890)2.31893797
64Abnormality of skull ossification (HP:0002703)2.31230910
65Chest pain (HP:0100749)2.30030143
66Recurrent bacterial skin infections (HP:0005406)2.26375420
6711 pairs of ribs (HP:0000878)2.25713899
68Missing ribs (HP:0000921)2.24804315
69Gingival bleeding (HP:0000225)2.23558587
70Cystic hygroma (HP:0000476)2.20665962
71Arterial thrombosis (HP:0004420)2.20568993
72Asymmetry of the thorax (HP:0001555)2.19155647
73Biliary tract neoplasm (HP:0100574)2.18595592
74Stomach cancer (HP:0012126)2.17949037
75Myelomeningocele (HP:0002475)2.17855902
76Fatigue (HP:0012378)2.16873915
77Inappropriate behavior (HP:0000719)2.15917815
78Uterine neoplasm (HP:0010784)2.14915008
79Aplasia/Hypoplasia of the macula (HP:0008059)2.14845171
80Abnormality of the heme biosynthetic pathway (HP:0010472)2.14604798
81Aplasia/Hypoplasia of the uvula (HP:0010293)2.13287179
82Abnormality of the preputium (HP:0100587)2.12552702
83Segmental peripheral demyelination/remyelination (HP:0003481)2.09508866
84Cafe-au-lait spot (HP:0000957)2.09135098
85Abnormality of the astrocytes (HP:0100707)2.08530257
86Astrocytoma (HP:0009592)2.08530257
87Recurrent abscess formation (HP:0002722)2.08374517
88Median cleft lip (HP:0000161)2.06869246
89Neoplasm of the thyroid gland (HP:0100031)2.02825369
90Aplasia cutis congenita (HP:0001057)1.98216040
91Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.97934578
92Sandal gap (HP:0001852)1.97508812
93Microglossia (HP:0000171)1.97220477
94Centrally nucleated skeletal muscle fibers (HP:0003687)1.96794996
95Portal hypertension (HP:0001409)1.96712137
96Vertebral arch anomaly (HP:0008438)1.96378015
97Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96231149
98Tented upper lip vermilion (HP:0010804)1.95449457
99Hamartoma (HP:0010566)1.95215602
100Drooling (HP:0002307)1.94861845
101Birth length less than 3rd percentile (HP:0003561)1.94804356
102Tetraparesis (HP:0002273)1.94160493
103Oligodontia (HP:0000677)1.94097502
104Abnormality of the hepatic vasculature (HP:0006707)1.93018332
105Renal cortical cysts (HP:0000803)1.92343191
106Aplasia/Hypoplasia of the sternum (HP:0006714)1.92308199
107Neoplasm of striated muscle (HP:0009728)1.92135137
108Benign neoplasm of the central nervous system (HP:0100835)1.91973511
109Low anterior hairline (HP:0000294)1.91194829
110Micronodular cirrhosis (HP:0001413)1.91111241
111Ectopic kidney (HP:0000086)1.89551717
112Morphological abnormality of the middle ear (HP:0008609)1.89443271
113Obsessive-compulsive behavior (HP:0000722)1.89333874
114Smooth philtrum (HP:0000319)1.89255973
115Abnormality of oral frenula (HP:0000190)1.89063636
116Intestinal atresia (HP:0011100)1.88568893
117Mesomelia (HP:0003027)1.87271258
118Abnormality of chromosome segregation (HP:0002916)1.86473584
119Optic nerve coloboma (HP:0000588)1.86265422
120Selective tooth agenesis (HP:0001592)1.84377060
121Fair hair (HP:0002286)1.83951834
122Sparse lateral eyebrow (HP:0005338)1.83748678
123Freckling (HP:0001480)1.83600427
124Abnormality of the fingertips (HP:0001211)1.82294707
125Hypoplastic labia majora (HP:0000059)1.82076003
126Meckel diverticulum (HP:0002245)1.80750595
127Small intestinal stenosis (HP:0012848)1.79699061
128Duodenal stenosis (HP:0100867)1.79699061
129Abnormal biliary tract morphology (HP:0012440)1.79211055
130Disinhibition (HP:0000734)1.79025065
131Generalized hypopigmentation of hair (HP:0011358)1.79002388
132Abnormality of the frontal sinuses (HP:0002687)1.77273047
133Supernumerary ribs (HP:0005815)1.77153253
134Abnormality of the duodenum (HP:0002246)1.77003357
135Excessive salivation (HP:0003781)1.76886855
136Abnormal hair whorl (HP:0010721)1.76875410
137Septo-optic dysplasia (HP:0100842)1.76459644
138Aplasia/Hypoplasia affecting the retina (HP:0008061)1.75929198
139Thickened helices (HP:0000391)1.75544694
140Fibrous tissue neoplasm (HP:0012316)1.75271917
141Renal cell carcinoma (HP:0005584)1.74760473
142Subcapsular cataract (HP:0000523)1.74250990
143Blue irides (HP:0000635)1.73404208
144Cubitus valgus (HP:0002967)1.72029979
145Overgrowth (HP:0001548)1.71806173
146Supernumerary spleens (HP:0009799)1.71685790
147Meningioma (HP:0002858)1.70561855
148Viral hepatitis (HP:0006562)1.69910413
149Abnormality of the labia minora (HP:0012880)1.69859858
150Overlapping toe (HP:0001845)1.69162724
151Myelodysplasia (HP:0002863)1.69034030
152Gastrointestinal atresia (HP:0002589)1.68718204
153Fibroma (HP:0010614)1.68120479
154Sloping forehead (HP:0000340)1.68053701
155Abnormality of the labia majora (HP:0012881)1.67722826
156Megalencephaly (HP:0001355)1.67589073
157Prolonged bleeding time (HP:0003010)1.67223198
158Abnormal delayed hypersensitivity skin test (HP:0002963)1.67064682
159Abnormality of the ileum (HP:0001549)1.66838897
160Relative macrocephaly (HP:0004482)1.66766126
161Chronic hepatic failure (HP:0100626)1.66705583
162Uterine leiomyosarcoma (HP:0002891)1.66324951
163Leiomyosarcoma (HP:0100243)1.66324951
164Type I transferrin isoform profile (HP:0003642)1.66078526
165Absent eyebrow (HP:0002223)1.66035972
166Skull defect (HP:0001362)1.65984117
167Underdeveloped nasal alae (HP:0000430)1.64936411
168Abnormality of the renal collecting system (HP:0004742)1.64799323
169Abnormality of the carotid arteries (HP:0005344)1.63961978
170Long eyelashes (HP:0000527)1.63693358
171White forelock (HP:0002211)1.62842657
172Thin upper lip vermilion (HP:0000219)1.60516920
173Spontaneous abortion (HP:0005268)1.59544959
174Abnormality of the metopic suture (HP:0005556)1.59350089
175Chromsome breakage (HP:0040012)1.56347308
176Polycystic kidney dysplasia (HP:0000113)1.55544876
177Single transverse palmar crease (HP:0000954)1.53632055
178Wide intermamillary distance (HP:0006610)1.52559159
179Synophrys (HP:0000664)1.52529654
180Embryonal neoplasm (HP:0002898)1.52410573

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK33.52600274
2BRD43.48762523
3RIPK13.37533808
4ZAK3.05700370
5MKNK22.68552858
6SIK32.51919884
7MAP3K102.50397294
8YES12.43735317
9NUAK12.42836091
10BLK2.42189593
11CASK2.04381877
12MATK2.04132160
13MKNK12.03915909
14MAP3K22.01432117
15CDK122.01086506
16TTK2.00996698
17TXK2.00160100
18BRSK21.96092965
19PASK1.95028187
20FGFR21.89825808
21ACVR1B1.78360708
22SRPK11.71643313
23MAPK151.69392570
24NEK11.68313321
25KSR11.58499257
26TAF11.55856012
27FRK1.55224818
28CDC71.54510995
29SCYL21.53960298
30WEE11.52987904
31JAK31.47417310
32CLK11.44284728
33MAP3K141.40598056
34PIK3CA1.37710447
35PRPF4B1.36341321
36FGFR31.36042584
37IRAK41.34913254
38ERBB31.31062468
39NEK91.30890649
40MARK31.30124649
41EIF2AK11.27626972
42TRIM281.27231562
43CSK1.25689965
44STK241.25410247
45FGFR11.25196828
46TAOK21.22451146
47PLK41.21764524
48EPHA31.21332180
49PNCK1.19643840
50KIT1.19250179
51MAP4K11.18988944
52CDK31.18575745
53CHEK21.14247049
54SGK21.10573243
55SIK11.10343400
56LATS11.09903977
57WNK31.09299007
58STK391.09019248
59HIPK21.08586150
60STK38L1.07663054
61EEF2K1.07453238
62ATR1.07408420
63DDR21.06526655
64PDGFRA1.04274728
65ERBB41.04025636
66TRPM71.03581926
67SIK21.02232833
68CSF1R1.01999154
69PBK1.00804556
70BMPR21.00244757
71INSRR0.99916989
72PIM10.99166589
73LATS20.94190495
74MST40.93534003
75ATM0.92729067
76VRK10.91312811
77EIF2AK20.89621194
78DMPK0.87399865
79NEK20.86951711
80FGFR40.86328654
81CAMK1G0.86188841
82IRAK30.86145114
83MAP3K80.86141131
84RPS6KB20.85992120
85RAF10.85123934
86TNK20.84599944
87RPS6KA40.83881686
88ZAP700.83577198
89CAMK1D0.80684844
90SGK30.80563899
91LCK0.80073286
92STK30.79655541
93STK160.79157250
94PRKD30.79029477
95PRKCI0.78914093
96TEC0.77184554
97ALK0.76900254
98PLK30.76577543
99MAP2K60.75323426
100CHUK0.73517500
101MET0.71815705
102DYRK30.71485065
103CDK60.70410740
104PDGFRB0.70078670
105CDC42BPA0.68886293
106KSR20.67250916
107MTOR0.66626613
108TGFBR20.64518553
109GRK10.64043258
110RPS6KB10.63234190
111TGFBR10.62684568
112MELK0.61544286
113MAPK70.59996033
114LYN0.59906338
115PLK10.59152178
116AKT30.57989432
117CSNK1E0.56439558
118MAP2K30.56307395
119SGK4940.56168982
120SGK2230.56168982
121WNK10.55594572
122NEK60.55425811
123RET0.55385519
124PRKD20.53853900
125TNIK0.53291240
126AKT10.51324122
127OBSCN0.51293369
128IKBKE0.51164934
129CHEK10.50387507
130CDK70.49461124
131MAPK140.48993063
132BTK0.48909824
133TYK20.48665047
134PIK3CG0.48170936
135TIE10.47858527
136PRKCH0.47280338
137CDK20.46681124
138IKBKB0.45189558
139DYRK1A0.44694952
140NLK0.44283022
141MAPK130.44144417
142MAPK100.43015050
143PRKAA20.42312048
144PRKDC0.42274461
145CDK10.42115989
146MAP3K130.41855139
147GSK3B0.40813017
148MST1R0.40643359
149PKN20.39755708
150STK40.39735933
151CSNK1A10.39424568
152TSSK60.39208410
153PTK60.38807674
154BCR0.38804283
155ICK0.38067614
156NTRK30.37015789
157IRAK10.36370412

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.49587170
2DNA replication_Homo sapiens_hsa030302.87050200
3Thyroid cancer_Homo sapiens_hsa052162.13857754
4Nucleotide excision repair_Homo sapiens_hsa034202.10296690
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.92067178
6RNA degradation_Homo sapiens_hsa030181.87225829
7Colorectal cancer_Homo sapiens_hsa052101.84995401
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84506658
9Notch signaling pathway_Homo sapiens_hsa043301.82974605
10Adherens junction_Homo sapiens_hsa045201.78480044
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71845422
12Transcriptional misregulation in cancer_Homo sapiens_hsa052021.70639055
13Renal cell carcinoma_Homo sapiens_hsa052111.70575404
14Measles_Homo sapiens_hsa051621.65208850
15Glioma_Homo sapiens_hsa052141.64709969
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.63378088
17Dorso-ventral axis formation_Homo sapiens_hsa043201.59418934
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.58869100
19Basal transcription factors_Homo sapiens_hsa030221.54573982
20TGF-beta signaling pathway_Homo sapiens_hsa043501.54166367
21Herpes simplex infection_Homo sapiens_hsa051681.53622891
22NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48198857
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48011433
24Primary immunodeficiency_Homo sapiens_hsa053401.47604823
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47029453
26ErbB signaling pathway_Homo sapiens_hsa040121.41989022
27Pancreatic cancer_Homo sapiens_hsa052121.38201157
28mTOR signaling pathway_Homo sapiens_hsa041501.29021946
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.28740835
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25195734
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22503356
32Selenocompound metabolism_Homo sapiens_hsa004501.19162757
33Fanconi anemia pathway_Homo sapiens_hsa034601.18682947
34One carbon pool by folate_Homo sapiens_hsa006701.18374805
35Base excision repair_Homo sapiens_hsa034101.17363741
36Taste transduction_Homo sapiens_hsa047421.16118763
37Steroid biosynthesis_Homo sapiens_hsa001001.15624957
38Leishmaniasis_Homo sapiens_hsa051401.14572637
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.14551557
40Proteoglycans in cancer_Homo sapiens_hsa052051.14059715
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.13947904
42Influenza A_Homo sapiens_hsa051641.13322234
43Vitamin B6 metabolism_Homo sapiens_hsa007501.06749120
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.05559074
45Non-homologous end-joining_Homo sapiens_hsa034501.04932156
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.04154029
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.03705328
48Cell cycle_Homo sapiens_hsa041101.03355682
49Lysine degradation_Homo sapiens_hsa003101.03252496
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.03073804
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.02823414
52Oocyte meiosis_Homo sapiens_hsa041140.99420089
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98711991
54MicroRNAs in cancer_Homo sapiens_hsa052060.96002721
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.95514905
56mRNA surveillance pathway_Homo sapiens_hsa030150.95097090
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94276405
58Spliceosome_Homo sapiens_hsa030400.93576665
59Hepatitis B_Homo sapiens_hsa051610.93277814
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92718463
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92610909
62p53 signaling pathway_Homo sapiens_hsa041150.89795507
63Hematopoietic cell lineage_Homo sapiens_hsa046400.89123071
64Propanoate metabolism_Homo sapiens_hsa006400.88608099
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.87886160
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87865101
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87424393
68Nicotine addiction_Homo sapiens_hsa050330.85445621
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83885273
70HTLV-I infection_Homo sapiens_hsa051660.83499452
71Platelet activation_Homo sapiens_hsa046110.83285155
72Long-term potentiation_Homo sapiens_hsa047200.82671407
73Protein export_Homo sapiens_hsa030600.82590590
74ABC transporters_Homo sapiens_hsa020100.82192981
75Melanoma_Homo sapiens_hsa052180.82173945
76Other glycan degradation_Homo sapiens_hsa005110.81574575
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.80995219
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77953477
79Choline metabolism in cancer_Homo sapiens_hsa052310.77922110
80Estrogen signaling pathway_Homo sapiens_hsa049150.77433155
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76806316
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76608199
83Osteoclast differentiation_Homo sapiens_hsa043800.76600899
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76384364
85Morphine addiction_Homo sapiens_hsa050320.75528556
86Hedgehog signaling pathway_Homo sapiens_hsa043400.75310952
87Hepatitis C_Homo sapiens_hsa051600.74202561
88Insulin secretion_Homo sapiens_hsa049110.70980147
89Bladder cancer_Homo sapiens_hsa052190.70896445
90HIF-1 signaling pathway_Homo sapiens_hsa040660.70232745
91Inositol phosphate metabolism_Homo sapiens_hsa005620.70216173
92Homologous recombination_Homo sapiens_hsa034400.69441867
93Circadian entrainment_Homo sapiens_hsa047130.69213412
94B cell receptor signaling pathway_Homo sapiens_hsa046620.68539164
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68004794
96Acute myeloid leukemia_Homo sapiens_hsa052210.67919443
97TNF signaling pathway_Homo sapiens_hsa046680.67825961
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67433067
99Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66706826
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65928633
101T cell receptor signaling pathway_Homo sapiens_hsa046600.65611749
102Circadian rhythm_Homo sapiens_hsa047100.65544958
103Insulin signaling pathway_Homo sapiens_hsa049100.65320428
104Autoimmune thyroid disease_Homo sapiens_hsa053200.64549211
105Prolactin signaling pathway_Homo sapiens_hsa049170.64499167
106Vitamin digestion and absorption_Homo sapiens_hsa049770.64367779
107N-Glycan biosynthesis_Homo sapiens_hsa005100.64049919
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63541201
109Chronic myeloid leukemia_Homo sapiens_hsa052200.62501853
110Chemokine signaling pathway_Homo sapiens_hsa040620.62476388
111Pathways in cancer_Homo sapiens_hsa052000.62298311
112Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58919679
113Insulin resistance_Homo sapiens_hsa049310.58583344
114Glucagon signaling pathway_Homo sapiens_hsa049220.57065153
115Wnt signaling pathway_Homo sapiens_hsa043100.55476021
116Calcium signaling pathway_Homo sapiens_hsa040200.54721878
117Allograft rejection_Homo sapiens_hsa053300.54146296
118RNA transport_Homo sapiens_hsa030130.53877532
119Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53818772
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53574666
121Viral carcinogenesis_Homo sapiens_hsa052030.53344549
122Small cell lung cancer_Homo sapiens_hsa052220.53054289
123Alcoholism_Homo sapiens_hsa050340.52982655
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.52372690
125Protein digestion and absorption_Homo sapiens_hsa049740.51922708
126Apoptosis_Homo sapiens_hsa042100.49273602
127Tight junction_Homo sapiens_hsa045300.49242590
128Thyroid hormone synthesis_Homo sapiens_hsa049180.49053636
129Epstein-Barr virus infection_Homo sapiens_hsa051690.48569931
130Type II diabetes mellitus_Homo sapiens_hsa049300.48410078
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.48312217
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47825171
133Melanogenesis_Homo sapiens_hsa049160.47264056
134African trypanosomiasis_Homo sapiens_hsa051430.46799765
135FoxO signaling pathway_Homo sapiens_hsa040680.46470345
136Cocaine addiction_Homo sapiens_hsa050300.46243483
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46157704
138AMPK signaling pathway_Homo sapiens_hsa041520.45788695
139Prostate cancer_Homo sapiens_hsa052150.45623485
140Cholinergic synapse_Homo sapiens_hsa047250.45197961
141Endometrial cancer_Homo sapiens_hsa052130.44818386
142Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44452812
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.44402221
144Basal cell carcinoma_Homo sapiens_hsa052170.43699412
145Sphingolipid metabolism_Homo sapiens_hsa006000.43057295
146Non-small cell lung cancer_Homo sapiens_hsa052230.42024603
147Malaria_Homo sapiens_hsa051440.41438203
148Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41006807
149Hippo signaling pathway_Homo sapiens_hsa043900.40956900
150Focal adhesion_Homo sapiens_hsa045100.40749157
151GnRH signaling pathway_Homo sapiens_hsa049120.38389825
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.32992497
153Fatty acid biosynthesis_Homo sapiens_hsa000610.32818554

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