RB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.89668142
2nuclear pore complex assembly (GO:0051292)4.66775167
3nuclear pore organization (GO:0006999)4.09445655
4negative regulation of cell killing (GO:0031342)4.07770799
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.07770799
6positive regulation of gamma-delta T cell activation (GO:0046645)4.02237366
7pore complex assembly (GO:0046931)3.69071625
8cytoplasmic mRNA processing body assembly (GO:0033962)3.63598577
9mitotic sister chromatid cohesion (GO:0007064)3.57885281
10positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.52381287
11positive regulation of histone deacetylation (GO:0031065)3.46786203
12regulation of B cell receptor signaling pathway (GO:0050855)3.44295629
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.36188784
14tolerance induction (GO:0002507)3.35900109
15detection of molecule of bacterial origin (GO:0032490)3.30916096
16response to peptidoglycan (GO:0032494)3.27818201
17negative regulation of interleukin-12 production (GO:0032695)3.19490885
18DNA unwinding involved in DNA replication (GO:0006268)3.16658616
19histamine secretion (GO:0001821)3.12204994
20response to muramyl dipeptide (GO:0032495)3.10689497
21regulation of interleukin-12 biosynthetic process (GO:0045075)3.10428238
22glucocorticoid receptor signaling pathway (GO:0042921)3.10020391
23positive thymic T cell selection (GO:0045059)3.08117573
24negative T cell selection (GO:0043383)3.06994665
25dosage compensation (GO:0007549)3.06726506
26B cell receptor signaling pathway (GO:0050853)3.06132459
27negative thymic T cell selection (GO:0045060)3.03780009
28negative regulation of erythrocyte differentiation (GO:0045647)3.01608191
29cellular response to thyroid hormone stimulus (GO:0097067)3.01497437
30COPI coating of Golgi vesicle (GO:0048205)2.99832966
31Golgi transport vesicle coating (GO:0048200)2.99832966
32regulation of gamma-delta T cell differentiation (GO:0045586)2.99720751
33histone H3-K9 demethylation (GO:0033169)2.99064806
34corticosteroid receptor signaling pathway (GO:0031958)2.98384677
35regulation of RNA export from nucleus (GO:0046831)2.96320148
36embryonic hemopoiesis (GO:0035162)2.93468578
37histone H3-K4 trimethylation (GO:0080182)2.91301350
38negative regulation of B cell proliferation (GO:0030889)2.90032673
39lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86288618
40regulation of early endosome to late endosome transport (GO:2000641)2.85047547
41macrophage activation involved in immune response (GO:0002281)2.84676073
42regulation of interferon-beta biosynthetic process (GO:0045357)2.84027581
43B cell proliferation (GO:0042100)2.82592866
44glycosphingolipid catabolic process (GO:0046479)2.81869734
45regulation of gamma-delta T cell activation (GO:0046643)2.81236985
46positive regulation of B cell differentiation (GO:0045579)2.79981837
47hypotonic response (GO:0006971)2.78105338
48positive T cell selection (GO:0043368)2.77171878
49thymic T cell selection (GO:0045061)2.76019380
50T cell selection (GO:0045058)2.74984287
51stress fiber assembly (GO:0043149)2.74383428
52regulation of nucleobase-containing compound transport (GO:0032239)2.73233581
53embryonic process involved in female pregnancy (GO:0060136)2.72854110
54response to interleukin-15 (GO:0070672)2.68759921
55growth hormone receptor signaling pathway (GO:0060396)2.68588927
56regulation of histone deacetylation (GO:0031063)2.68341539
57megakaryocyte development (GO:0035855)2.67942750
58positive regulation of granulocyte differentiation (GO:0030854)2.66429328
59regulation of alpha-beta T cell proliferation (GO:0046640)2.63688663
60T cell costimulation (GO:0031295)2.62494642
61negative regulation of granulocyte differentiation (GO:0030853)2.61959354
62immunoglobulin mediated immune response (GO:0016064)2.61652650
63erythrocyte maturation (GO:0043249)2.61015385
64regulation of establishment of cell polarity (GO:2000114)2.60425327
65lymphocyte costimulation (GO:0031294)2.59855959
66leukocyte tethering or rolling (GO:0050901)2.58492880
67detection of external biotic stimulus (GO:0098581)2.58305208
68histone H3-K4 methylation (GO:0051568)2.58220763
69regulation of DNA endoreduplication (GO:0032875)2.58198781
70epithelial cell differentiation involved in prostate gland development (GO:0060742)2.57379271
71* hepatocyte apoptotic process (GO:0097284)2.56810992
72leukocyte aggregation (GO:0070486)2.56694959
73modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.56501158
74positive regulation by organism of defense response of other organism involved in symbiotic interact2.56501158
75modulation by symbiont of host immune response (GO:0052553)2.56501158
76positive regulation by symbiont of host defense response (GO:0052509)2.56501158
77modulation by symbiont of host defense response (GO:0052031)2.56501158
78modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.56501158
79positive regulation of leukocyte degranulation (GO:0043302)2.55530202
80regulation of NFAT protein import into nucleus (GO:0051532)2.55362510
81positive regulation of interferon-alpha production (GO:0032727)2.53926958
82B cell homeostasis (GO:0001782)2.53716618
83regulation of B cell differentiation (GO:0045577)2.53109887
84detection of other organism (GO:0098543)2.51947013
85cell adhesion mediated by integrin (GO:0033627)2.51879592
86cellular response to ethanol (GO:0071361)2.51781332
87response to laminar fluid shear stress (GO:0034616)2.51269287
88regulation of granulocyte differentiation (GO:0030852)2.49761481
89antigen processing and presentation of endogenous antigen (GO:0019883)2.49608998
90negative regulation of necroptotic process (GO:0060546)2.47927624
91cellular response to interleukin-15 (GO:0071350)2.47847377
92germ cell migration (GO:0008354)2.47814238
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46706566
94germinal center formation (GO:0002467)2.46224533
95protoporphyrinogen IX metabolic process (GO:0046501)2.45823825
96positive regulation of oligodendrocyte differentiation (GO:0048714)2.45442383
97glycolipid catabolic process (GO:0019377)2.45154045
98coronary vasculature morphogenesis (GO:0060977)2.44407838
99regulation of interferon-alpha production (GO:0032647)2.44148847
100T-helper 1 type immune response (GO:0042088)2.43194115
101positive regulation of cellular amide metabolic process (GO:0034250)2.42996587
102regulation of macrophage cytokine production (GO:0010935)2.42883670
103pinocytosis (GO:0006907)2.42824268
104regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.42513160
105mitotic chromosome condensation (GO:0007076)2.41857238
106regulation of ARF protein signal transduction (GO:0032012)2.41612300
107phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.41264409
108regulation of B cell proliferation (GO:0030888)2.39879006
109T cell migration (GO:0072678)2.39616610
110positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.38236331
111response to thyroid hormone (GO:0097066)2.37467930
112oligosaccharide catabolic process (GO:0009313)2.37117057
113regulation of necroptotic process (GO:0060544)2.36585944
114peptidyl-lysine trimethylation (GO:0018023)2.35638486
115positive regulation of protein deacetylation (GO:0090312)2.35281597
116myeloid cell development (GO:0061515)2.34872726
117DNA topological change (GO:0006265)2.34785729
118antigen receptor-mediated signaling pathway (GO:0050851)2.34251609
119JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.34208191
120histone H3-K36 demethylation (GO:0070544)2.34168222
121positive regulation of chemokine secretion (GO:0090197)2.34044927
122definitive hemopoiesis (GO:0060216)2.33770674
123barbed-end actin filament capping (GO:0051016)2.33323284
124regulation of protein deacetylation (GO:0090311)2.32820465
125positive regulation of erythrocyte differentiation (GO:0045648)2.32210827
126lymphocyte homeostasis (GO:0002260)2.29717025
127negative regulation of stress fiber assembly (GO:0051497)2.29485927
128positive regulation of macrophage cytokine production (GO:0060907)2.28659835
129regulation of T cell tolerance induction (GO:0002664)2.28508774
130interferon-gamma production (GO:0032609)2.27680696
1313-UTR-mediated mRNA stabilization (GO:0070935)2.27676149
132cellular hyperosmotic response (GO:0071474)2.27147445
133negative regulation of anoikis (GO:2000811)2.27097596
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27039683
135antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27039683
136positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26674268
137peptidyl-threonine phosphorylation (GO:0018107)2.26251165
138neutrophil activation (GO:0042119)2.25881873
139regulation of type I interferon-mediated signaling pathway (GO:0060338)2.25795161
140histamine transport (GO:0051608)2.25582268
141toll-like receptor signaling pathway (GO:0002224)2.25479780
142nerve growth factor signaling pathway (GO:0038180)2.24299287
143mature B cell differentiation (GO:0002335)2.24033836
144response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.23425706
145response to host (GO:0075136)2.23425706
146response to host defenses (GO:0052200)2.23425706
147interferon-gamma-mediated signaling pathway (GO:0060333)2.22299628
148leukocyte cell-cell adhesion (GO:0007159)2.22027641
149positive regulation of lamellipodium assembly (GO:0010592)2.21913440
150peptidyl-threonine modification (GO:0018210)2.21580338
151osteoclast differentiation (GO:0030316)2.21573516
152necroptotic process (GO:0070266)2.21140898
153cellular response to arsenic-containing substance (GO:0071243)2.21096325
154protein localization to endosome (GO:0036010)2.20961272
155cellular response to growth hormone stimulus (GO:0071378)2.20601261
156response to host immune response (GO:0052572)2.20579659
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20579659
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.20514171
159V(D)J recombination (GO:0033151)2.19239203
160MyD88-dependent toll-like receptor signaling pathway (GO:0002755)2.17326463
161COPII vesicle coating (GO:0048208)2.16832916
162neutrophil activation involved in immune response (GO:0002283)2.16415751
163cortical actin cytoskeleton organization (GO:0030866)2.16278347
164membrane raft organization (GO:0031579)2.15322987
165natural killer cell differentiation (GO:0001779)2.14954866
166T cell homeostasis (GO:0043029)2.14794429
167positive regulation of p38MAPK cascade (GO:1900745)2.14354264
168activated T cell proliferation (GO:0050798)2.14273462
169negative regulation of histone methylation (GO:0031061)2.14228465
170I-kappaB phosphorylation (GO:0007252)2.13800157
171positive regulation of lamellipodium organization (GO:1902745)2.13638180
172positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.13482172
173regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.13482172
174detection of biotic stimulus (GO:0009595)2.12927439
175T cell receptor signaling pathway (GO:0050852)2.11023180
176cellular extravasation (GO:0045123)2.10992034
177regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.10060161
178Notch signaling involved in heart development (GO:0061314)2.09993551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.70832775
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.35852611
3E2F7_22180533_ChIP-Seq_HELA_Human3.59700191
4* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25692474
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.02709310
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.79165642
7RUNX_20019798_ChIP-Seq_JUKART_Human2.74874832
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.72494171
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.67286828
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.60598878
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59451538
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.56427594
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48278909
14SCL_19346495_ChIP-Seq_HPC-7_Human2.39717511
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35699248
16* IRF8_27001747_Chip-Seq_BMDM_Mouse2.33829714
17GATA1_22025678_ChIP-Seq_K562_Human2.30438278
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08507805
19* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.99083205
20TCF7_22412390_ChIP-Seq_EML_Mouse1.98665904
21MYB_26560356_Chip-Seq_TH2_Human1.96175980
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89416230
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87972252
24MYC_22102868_ChIP-Seq_BL_Human1.85732826
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.84934314
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.82871411
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.82729447
28AR_21909140_ChIP-Seq_LNCAP_Human1.81492360
29GATA1_19941826_ChIP-Seq_K562_Human1.81319484
30TFEB_21752829_ChIP-Seq_HELA_Human1.79010192
31MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.75958674
32MYB_26560356_Chip-Seq_TH1_Human1.75051524
33TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.74498650
34CLOCK_20551151_ChIP-Seq_293T_Human1.74265266
35VDR_21846776_ChIP-Seq_THP-1_Human1.73096162
36MAF_26560356_Chip-Seq_TH1_Human1.72351145
37KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72113355
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71373119
39CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70255965
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.69791992
41VDR_24763502_ChIP-Seq_THP-1_Human1.66987262
42PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63825845
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63283603
44VDR_24787735_ChIP-Seq_THP-1_Human1.62469565
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60699523
46UTX_26944678_Chip-Seq_JUKART_Human1.58309823
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55407224
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.53997840
49* KDM2B_26808549_Chip-Seq_DND41_Human1.53853993
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53501688
51SPI1_23127762_ChIP-Seq_K562_Human1.52327360
52* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.51201282
53* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.50650210
54GATA2_19941826_ChIP-Seq_K562_Human1.46683983
55* GATA3_27048872_Chip-Seq_THYMUS_Human1.44758098
56NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42712064
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.40730232
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.40292681
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38404128
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37173621
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36068082
62* E2F1_21310950_ChIP-Seq_MCF-7_Human1.35990908
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34397149
64RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34239452
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34063599
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.33217551
67E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.31788046
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.30942865
69GATA2_21666600_ChIP-Seq_HMVEC_Human1.30574822
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30402194
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29983200
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27740294
73PU_27001747_Chip-Seq_BMDM_Mouse1.26405217
74EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25343888
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.24920359
76TP53_16413492_ChIP-PET_HCT116_Human1.24574114
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23690166
78FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.20185334
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20134103
80SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20134103
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19046791
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18655664
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.17436211
84GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16926451
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16601544
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16335302
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16317331
88BP1_19119308_ChIP-ChIP_Hs578T_Human1.14780489
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12321919
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10249470
91FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09003936
92* SPI1_23547873_ChIP-Seq_NB4_Human1.08104414
93KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07877977
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07077920
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05749359
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.03786939
97SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02229370
98CIITA_25753668_ChIP-Seq_RAJI_Human1.01331937
99* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01234339
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.99658425
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99023999
102GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97858094
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97495924
104CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95672617
105MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94771610
106ELK3_25401928_ChIP-Seq_HUVEC_Human0.92581026
107* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92124409
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92106358
109UBF1/2_26484160_Chip-Seq_HMECs_Human0.91898175
110TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91455992
111KDM2B_26808549_Chip-Seq_K562_Human0.90749427
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90322907
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88562439
114EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87955200
115BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87861315
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86510698
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86503526
118RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86347901
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86263964
120* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85330241
121TCF4_18268006_ChIP-ChIP_LS174T_Human0.85242746
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84752040
123* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.84260952
124MAF_26560356_Chip-Seq_TH2_Human0.84119234
125* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.83642453
126STAT6_21828071_ChIP-Seq_BEAS2B_Human0.83561163
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83496117
128BRD4_25478319_ChIP-Seq_HGPS_Human0.82237178
129WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.81049704
130TP63_17297297_ChIP-ChIP_HaCaT_Human0.80529610
131WT1_19549856_ChIP-ChIP_CCG9911_Human0.79753872
132SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78871260
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78759797
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.78065808
135CJUN_26792858_Chip-Seq_BT549_Human0.77790712
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77783858
137FOXA1_25552417_ChIP-Seq_VCAP_Human0.77695788
138RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.76886518
139GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76502213
140RXR_22108803_ChIP-Seq_LS180_Human0.76400456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.51055567
2* MP0003300_gastrointestinal_ulcer3.08748167
3MP0005058_abnormal_lysosome_morphology2.81749397
4MP0001835_abnormal_antigen_presentation2.67474399
5MP0005671_abnormal_response_to2.67473934
6* MP0002166_altered_tumor_susceptibility2.57687279
7MP0003763_abnormal_thymus_physiology2.51334394
8MP0000685_abnormal_immune_system2.46541657
9MP0001800_abnormal_humoral_immune2.40832591
10MP0005387_immune_system_phenotype2.37226226
11MP0001790_abnormal_immune_system2.37226226
12MP0003303_peritoneal_inflammation2.29972756
13MP0004147_increased_porphyrin_level2.16648596
14* MP0002398_abnormal_bone_marrow2.12071140
15MP0003656_abnormal_erythrocyte_physiolo2.10891980
16MP0002452_abnormal_antigen_presenting2.08082668
17* MP0002006_tumorigenesis2.04484759
18MP0005000_abnormal_immune_tolerance2.04076496
19MP0003705_abnormal_hypodermis_morpholog2.03397686
20* MP0002877_abnormal_melanocyte_morpholog1.99933723
21MP0002420_abnormal_adaptive_immunity1.99042320
22MP0010352_gastrointestinal_tract_polyps1.97514229
23MP0001819_abnormal_immune_cell1.96431508
24MP0005451_abnormal_body_composition1.95571124
25MP0005310_abnormal_salivary_gland1.91731571
26MP0002396_abnormal_hematopoietic_system1.90385133
27MP0005076_abnormal_cell_differentiation1.89525470
28MP0003191_abnormal_cellular_cholesterol1.88706938
29MP0002723_abnormal_immune_serum1.87140266
30MP0001873_stomach_inflammation1.87108839
31MP0003172_abnormal_lysosome_physiology1.83666116
32MP0004808_abnormal_hematopoietic_stem1.82843505
33MP0004510_myositis1.79236913
34MP0005174_abnormal_tail_pigmentation1.78907103
35MP0003221_abnormal_cardiomyocyte_apopto1.72913957
36MP0000465_gastrointestinal_hemorrhage1.71865419
37* MP0000716_abnormal_immune_system1.71189333
38MP0004185_abnormal_adipocyte_glucose1.70938148
39MP0010155_abnormal_intestine_physiology1.69158288
40MP0002405_respiratory_system_inflammati1.68595762
41MP0005397_hematopoietic_system_phenotyp1.64907432
42MP0001545_abnormal_hematopoietic_system1.64907432
43MP0010307_abnormal_tumor_latency1.63471304
44* MP0002009_preneoplasia1.61905899
45MP0001851_eye_inflammation1.59936890
46MP0003436_decreased_susceptibility_to1.59600149
47MP0000703_abnormal_thymus_morphology1.54336924
48MP0002419_abnormal_innate_immunity1.53905888
49MP0000689_abnormal_spleen_morphology1.51939861
50MP0003866_abnormal_defecation1.50693401
51MP0002722_abnormal_immune_system1.50173692
52MP0002254_reproductive_system_inflammat1.48834372
53MP0005464_abnormal_platelet_physiology1.48266121
54MP0005025_abnormal_response_to1.43838086
55MP0008438_abnormal_cutaneous_collagen1.43738218
56MP0004947_skin_inflammation1.42105027
57MP0003045_fibrosis1.42098275
58* MP0002429_abnormal_blood_cell1.40675108
59MP0009278_abnormal_bone_marrow1.36980352
60* MP0010094_abnormal_chromosome_stability1.36789269
61MP0003183_abnormal_peptide_metabolism1.30650280
62MP0008260_abnormal_autophagy1.28779589
63MP0001915_intracranial_hemorrhage1.25207843
64MP0003091_abnormal_cell_migration1.24330405
65* MP0000733_abnormal_muscle_development1.24042231
66MP0000490_abnormal_crypts_of1.19893224
67MP0001879_abnormal_lymphatic_vessel1.18120600
68MP0002148_abnormal_hypersensitivity_rea1.17822980
69MP0009785_altered_susceptibility_to1.15576863
70MP0008961_abnormal_basal_metabolism1.14922004
71MP0000015_abnormal_ear_pigmentation1.14107794
72* MP0003448_altered_tumor_morphology1.12931249
73MP0005666_abnormal_adipose_tissue1.10856757
74MP0002095_abnormal_skin_pigmentation1.09556526
75MP0000371_diluted_coat_color1.08505200
76MP0010234_abnormal_vibrissa_follicle1.05901609
77MP0004130_abnormal_muscle_cell1.04085186
78* MP0003111_abnormal_nucleus_morphology1.03783519
79MP0003453_abnormal_keratinocyte_physiol1.03362706
80MP0009115_abnormal_fat_cell1.02390135
81MP0005171_absent_coat_pigmentation1.02284677
82MP0001845_abnormal_inflammatory_respons1.01700269
83* MP0003787_abnormal_imprinting1.01366008
84MP0009840_abnormal_foam_cell0.98901787
85MP0002998_abnormal_bone_remodeling0.97848525
86MP0002971_abnormal_brown_adipose0.97317028
87MP0001853_heart_inflammation0.96622616
88MP0000383_abnormal_hair_follicle0.96489303
89MP0005375_adipose_tissue_phenotype0.94124288
90MP0000350_abnormal_cell_proliferation0.93455117
91MP0009697_abnormal_copulation0.93430029
92MP0008057_abnormal_DNA_replication0.92866146
93MP0003724_increased_susceptibility_to0.92678818
94MP0003828_pulmonary_edema0.92003123
95MP0001730_embryonic_growth_arrest0.91437281
96MP0010678_abnormal_skin_adnexa0.90873722
97MP0006054_spinal_hemorrhage0.90122818
98MP0000003_abnormal_adipose_tissue0.89840283
99MP0002933_joint_inflammation0.87598018
100MP0002332_abnormal_exercise_endurance0.86272306
101MP0000747_muscle_weakness0.85951629
102MP0002060_abnormal_skin_morphology0.85494241
103MP0006082_CNS_inflammation0.84806165
104MP0001533_abnormal_skeleton_physiology0.83324829
105MP0004233_abnormal_muscle_weight0.82355684
106* MP0002019_abnormal_tumor_incidence0.80924544
107MP0008007_abnormal_cellular_replicative0.79317642
108MP0002928_abnormal_bile_duct0.78786902
109MP0003950_abnormal_plasma_membrane0.78527010
110MP0009384_cardiac_valve_regurgitation0.77878369
111* MP0005384_cellular_phenotype0.77588328
112MP0000249_abnormal_blood_vessel0.77179433
113MP0009333_abnormal_splenocyte_physiolog0.76984971
114MP0004883_abnormal_blood_vessel0.76902700
115MP0005248_abnormal_Harderian_gland0.76643597
116MP0004957_abnormal_blastocyst_morpholog0.75483849
117MP0003566_abnormal_cell_adhesion0.74124272
118MP0003690_abnormal_glial_cell0.72337556
119* MP0000858_altered_metastatic_potential0.72324754
120MP0000343_altered_response_to0.69565372
121MP0005621_abnormal_cell_physiology0.67556192
122MP0003077_abnormal_cell_cycle0.66226417
123MP0005334_abnormal_fat_pad0.64388334
124MP0004885_abnormal_endolymph0.62916075
125MP0000377_abnormal_hair_follicle0.61318095
126MP0005670_abnormal_white_adipose0.60270331
127MP0005409_darkened_coat_color0.60144538
128MP0008569_lethality_at_weaning0.59995301
129MP0002098_abnormal_vibrissa_morphology0.58107100

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.10759449
2Papilledema (HP:0001085)3.60458945
3Thyroiditis (HP:0100646)3.55053717
4Volvulus (HP:0002580)3.51158071
5Abnormality of B cell number (HP:0010975)3.49250131
6B lymphocytopenia (HP:0010976)3.49250131
7Recurrent viral infections (HP:0004429)3.39319424
8Abnormality of glycolipid metabolism (HP:0010969)3.24421183
9Abnormality of liposaccharide metabolism (HP:0010968)3.24421183
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.24421183
11Recurrent fungal infections (HP:0002841)3.12845822
12T lymphocytopenia (HP:0005403)2.95780816
13Agammaglobulinemia (HP:0004432)2.95634439
14Poikilocytosis (HP:0004447)2.92406893
15Recurrent abscess formation (HP:0002722)2.89777050
16Abnormality of T cell number (HP:0011839)2.83918463
17Panhypogammaglobulinemia (HP:0003139)2.80242263
18Recurrent bacterial skin infections (HP:0005406)2.77333240
19Eczematoid dermatitis (HP:0000976)2.76376855
20Optic neuritis (HP:0100653)2.73135962
21Retrobulbar optic neuritis (HP:0100654)2.73135962
22Severe combined immunodeficiency (HP:0004430)2.70226573
23IgM deficiency (HP:0002850)2.69498110
24Cellulitis (HP:0100658)2.65636347
25Osteolytic defects of the hand bones (HP:0009699)2.62371875
26Osteolytic defects of the phalanges of the hand (HP:0009771)2.62371875
27Myositis (HP:0100614)2.62324750
28Viral hepatitis (HP:0006562)2.59050993
29Insidious onset (HP:0003587)2.58731684
30Termporal pattern (HP:0011008)2.58731684
31Acanthocytosis (HP:0001927)2.56327566
32Orthostatic hypotension (HP:0001278)2.53869243
33Eosinophilia (HP:0001880)2.53020948
34Recurrent bronchitis (HP:0002837)2.51909827
35Orchitis (HP:0100796)2.51890890
36Hematochezia (HP:0002573)2.51208781
37Abnormality of the vasculature of the conjunctiva (HP:0008054)2.43446497
38Subacute progressive viral hepatitis (HP:0006572)2.43201096
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.41354640
40Combined immunodeficiency (HP:0005387)2.41112189
41Autoimmune thrombocytopenia (HP:0001973)2.41003371
42Recurrent cutaneous fungal infections (HP:0011370)2.39920943
43Chronic mucocutaneous candidiasis (HP:0002728)2.39920943
44Macroorchidism (HP:0000053)2.39146357
45Spondylolisthesis (HP:0003302)2.38716851
46Abnormality of eosinophils (HP:0001879)2.37996303
47Colitis (HP:0002583)2.36315023
48Vasculitis (HP:0002633)2.34918916
49Gastrointestinal stroma tumor (HP:0100723)2.34915078
50Verrucae (HP:0200043)2.33273039
51Papilloma (HP:0012740)2.33273039
52Inflammation of the large intestine (HP:0002037)2.33205163
53Dysostosis multiplex (HP:0000943)2.33129490
54Disinhibition (HP:0000734)2.32841246
55Meningitis (HP:0001287)2.31150975
56Aortic aneurysm (HP:0004942)2.28968941
57Narrow palate (HP:0000189)2.27617081
58Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.24069746
59Fatigue (HP:0012378)2.21587883
60Spinal cord lesions (HP:0100561)2.21502221
61Syringomyelia (HP:0003396)2.21502221
62Loss of speech (HP:0002371)2.18463624
63Ankyloglossia (HP:0010296)2.18109275
64Leukocytosis (HP:0001974)2.16418445
65Lip pit (HP:0100267)2.15287057
66Chronic diarrhea (HP:0002028)2.11922036
67Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.11229189
68Truncal obesity (HP:0001956)2.10553000
69Granulocytopenia (HP:0001913)2.10453766
70Gastrointestinal inflammation (HP:0004386)2.10122342
71Absent frontal sinuses (HP:0002688)2.09745657
72* Transitional cell carcinoma of the bladder (HP:0006740)2.09169917
73Autoimmune hemolytic anemia (HP:0001890)2.07918296
74Upper motor neuron abnormality (HP:0002127)2.03871252
75Pulmonary infiltrates (HP:0002113)2.03793667
76Lymphopenia (HP:0001888)2.02840944
77Abnormality of the left ventricular outflow tract (HP:0011103)2.02272242
78Subaortic stenosis (HP:0001682)2.02272242
79IgA deficiency (HP:0002720)2.02094833
80Osteomyelitis (HP:0002754)2.01160403
81Spontaneous hematomas (HP:0007420)2.01095032
82Deep philtrum (HP:0002002)2.01008023
83Abnormality of macrophages (HP:0004311)2.00909860
84Acute myeloid leukemia (HP:0004808)1.99835020
85Amelogenesis imperfecta (HP:0000705)1.99000312
86Abnormality of oral frenula (HP:0000190)1.97773429
87Prolonged bleeding time (HP:0003010)1.91743468
88Autoamputation (HP:0001218)1.91715539
89Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.91375110
90Conjunctival telangiectasia (HP:0000524)1.91317398
91Pustule (HP:0200039)1.90411561
92Abnormality of cells of the lymphoid lineage (HP:0012140)1.90408710
93Global brain atrophy (HP:0002283)1.90078074
94Arterial thrombosis (HP:0004420)1.89779896
95Recurrent skin infections (HP:0001581)1.89726995
96Uterine leiomyosarcoma (HP:0002891)1.89357610
97Leiomyosarcoma (HP:0100243)1.89357610
98Abnormality of T cells (HP:0002843)1.88743407
99Hypochromic microcytic anemia (HP:0004840)1.88682917
100Blepharitis (HP:0000498)1.88285901
101Asymmetry of the thorax (HP:0001555)1.87854390
102Tetraparesis (HP:0002273)1.87543240
103Mediastinal lymphadenopathy (HP:0100721)1.86637598
104* Bladder neoplasm (HP:0009725)1.85899626
105* Bladder carcinoma (HP:0002862)1.85899626
106Stomatitis (HP:0010280)1.85665893
107Coarse hair (HP:0002208)1.85241663
108Increased IgE level (HP:0003212)1.84714473
109Cutis marmorata (HP:0000965)1.84676691
110Broad face (HP:0000283)1.84532031
111Scanning speech (HP:0002168)1.84268692
112Heterotopia (HP:0002282)1.83826729
113Arterial tortuosity (HP:0005116)1.82489867
114Keratoconjunctivitis sicca (HP:0001097)1.81912733
115Vertebral arch anomaly (HP:0008438)1.80915824
116Periodontitis (HP:0000704)1.80752125
117Thick nail (HP:0001805)1.77825277
118Vacuolated lymphocytes (HP:0001922)1.77727241
119Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77600149
120Chronic obstructive pulmonary disease (HP:0006510)1.77513520
121Obstructive lung disease (HP:0006536)1.77513520
122Sepsis (HP:0100806)1.77367009
123Delayed closure of the anterior fontanelle (HP:0001476)1.76768981
124Chronic otitis media (HP:0000389)1.76353065
125Keratoconjunctivitis (HP:0001096)1.76242762
126Inappropriate behavior (HP:0000719)1.75890253
127Systemic lupus erythematosus (HP:0002725)1.75875261
128Papillary thyroid carcinoma (HP:0002895)1.75856580
129Cortical dysplasia (HP:0002539)1.74315265
130Chest pain (HP:0100749)1.74302960
131IgG deficiency (HP:0004315)1.73883640
132Cerebral aneurysm (HP:0004944)1.73393054
133Mucosal telangiectasiae (HP:0100579)1.71710924
134Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.69057872
135Abnormality of the lumbar spine (HP:0100712)1.68367932
136Cupped ribs (HP:0000887)1.67993434
137Malignant gastrointestinal tract tumors (HP:0006749)1.67241439
138Gastrointestinal carcinoma (HP:0002672)1.67241439
139Porencephaly (HP:0002132)1.66643732
140Gingivitis (HP:0000230)1.66590040
141Recurrent sinusitis (HP:0011108)1.66336844
142Vascular tortuosity (HP:0004948)1.66140538
143Long eyelashes (HP:0000527)1.65016355
144Mucopolysacchariduria (HP:0008155)1.63303790
145Urinary glycosaminoglycan excretion (HP:0003541)1.63303790
146Thoracic kyphosis (HP:0002942)1.62313361
147Thyroid carcinoma (HP:0002890)1.60743993
148Vertebral compression fractures (HP:0002953)1.60614540
149Distal lower limb amyotrophy (HP:0008944)1.60516658
150Flat acetabular roof (HP:0003180)1.60435675
151Myocardial infarction (HP:0001658)1.60376851
152Abnormal platelet volume (HP:0011876)1.59052927
153Hyperacusis (HP:0010780)1.58932153
15411 pairs of ribs (HP:0000878)1.58792909
155Cerebral inclusion bodies (HP:0100314)1.57930327
156Increased cerebral lipofuscin (HP:0011813)1.56969819
157Lymphedema (HP:0001004)1.56776921
158Polycythemia (HP:0001901)1.56723279
159Menstrual irregularities (HP:0000858)1.56116311
160Diminished motivation (HP:0000745)1.55989539
161Relative macrocephaly (HP:0004482)1.55618930
162Slow saccadic eye movements (HP:0000514)1.55372705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.18289442
2MAP3K62.93472666
3EEF2K2.93309620
4SCYL22.74780491
5MAP4K12.72939104
6CAMK1D2.47939731
7CAMK1G2.42721923
8IRAK32.33363241
9TGFBR22.28569293
10BMPR22.18653852
11BLK2.17825231
12FGFR32.09317575
13CDK122.05431488
14STK102.04854508
15MAP3K102.04185174
16BRD41.80677539
17NUAK11.78451731
18TAOK31.73521066
19PDGFRA1.72531024
20DMPK1.69202267
21JAK11.65677909
22KSR21.61274185
23JAK31.60258572
24ITK1.60002510
25* CDK91.55605455
26TRIB31.55404062
27TYK21.55009224
28TXK1.52932831
29TTN1.51310704
30ICK1.47941020
31TRPM71.43179143
32EPHB11.42065230
33MAP3K41.40572247
34RIPK41.40436932
35FGR1.34275003
36STK41.33781575
37SMG11.33447695
38NEK91.32470417
39MAP3K21.31509932
40HIPK21.28468530
41* CDK61.25106498
42SYK1.23132362
43KSR11.23021142
44MAP3K141.22580708
45LATS11.21334409
46SGK31.16755184
47HCK1.12380222
48RET1.11811787
49STK31.10399820
50CDC71.09746113
51SIK21.08399980
52EPHA31.07725629
53IKBKE1.07306265
54TAOK11.06015640
55DYRK1B1.02571469
56GRK61.02100999
57RIPK11.01341610
58BTK1.01222152
59FGFR40.95683223
60YES10.95540120
61LRRK20.94860637
62DDR20.94575908
63JAK20.94506784
64KIT0.92940726
65ZAP700.92593728
66MELK0.92074039
67PKN20.91553426
68PIM10.91228569
69NLK0.90275201
70MAP2K70.89718255
71SIK30.89060463
72CAMKK20.88584965
73IRAK10.88385570
74LCK0.85791030
75MAP3K80.85059302
76MAP2K30.84867896
77MAP3K130.84626651
78MARK30.84273517
79SGK20.83459218
80CSF1R0.82651694
81TEC0.81874714
82MARK20.81831884
83CHUK0.80540959
84MAP3K10.80232500
85FGFR20.80149297
86LATS20.78609924
87RAF10.77857911
88IRAK20.76287658
89PRKAA20.75087149
90IRAK40.74392521
91RPS6KA40.73965967
92PDGFRB0.73768066
93MATK0.71825889
94MAP3K70.71685078
95NEK10.71399635
96MST40.71034957
97CDK70.70948696
98STK240.70860478
99PRKCQ0.70471570
100PTK60.68509180
101PRKCH0.68407830
102ERBB30.67405996
103MAPKAPK30.66197030
104EIF2AK10.65661432
105TNIK0.65117947
106CSNK1A1L0.64984594
107NTRK20.63674375
108TAOK20.63401929
109MAPKAPK20.62840453
110MKNK20.59022702
111SRPK10.58113180
112CDK80.58089939
113MAPK110.58039159
114IKBKB0.57889289
115CCNB10.57659099
116CSK0.56930700
117DYRK30.56669335
118WNK10.56538562
119WEE10.55727655
120STK110.55322428
121MOS0.54497501
122CDC42BPA0.54449682
123SIK10.53980286
124BRAF0.53933005
125MTOR0.53566302
126CLK10.52670295
127MAP3K30.52255687
128PAK40.51061272
129* ABL10.50843388
130LYN0.50825983
131MAPKAPK50.49932793
132PIK3CG0.49635312
133PRKD20.49345258
134MAP3K50.48822233
135MAPK70.46579756
136TBK10.46574255
137EGFR0.44145427
138* CDK140.43606595
139* CHEK10.43316472
140AKT20.41620592
141* CDK40.41510035
142SGK10.41150203
143FES0.40836422
144ERN10.40087386
145GRK70.39664086
146PDK10.39385879
147NEK60.37992471

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.16526899
2B cell receptor signaling pathway_Homo sapiens_hsa046622.02246058
3Other glycan degradation_Homo sapiens_hsa005111.92118444
4Osteoclast differentiation_Homo sapiens_hsa043801.75115588
5T cell receptor signaling pathway_Homo sapiens_hsa046601.66349315
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64353854
7* Pancreatic cancer_Homo sapiens_hsa052121.61043661
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59381379
9Staphylococcus aureus infection_Homo sapiens_hsa051501.58289917
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.57360599
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51353836
12Leishmaniasis_Homo sapiens_hsa051401.48197095
13Hematopoietic cell lineage_Homo sapiens_hsa046401.46675822
14* Chronic myeloid leukemia_Homo sapiens_hsa052201.46281283
15NF-kappa B signaling pathway_Homo sapiens_hsa040641.45011607
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.43847302
17Dorso-ventral axis formation_Homo sapiens_hsa043201.43795060
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.41638326
19Toxoplasmosis_Homo sapiens_hsa051451.38118849
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36969319
21Chemokine signaling pathway_Homo sapiens_hsa040621.31934155
22Thyroid cancer_Homo sapiens_hsa052161.31333394
23Lysosome_Homo sapiens_hsa041421.28308495
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24715083
25Platelet activation_Homo sapiens_hsa046111.21643522
26Measles_Homo sapiens_hsa051621.20847046
27Legionellosis_Homo sapiens_hsa051341.17187282
28* Hepatitis B_Homo sapiens_hsa051611.16628008
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.16566424
30Phagosome_Homo sapiens_hsa041451.16457412
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.15684832
32* Bladder cancer_Homo sapiens_hsa052191.13786829
33Colorectal cancer_Homo sapiens_hsa052101.13609083
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.13211575
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13006593
36Viral myocarditis_Homo sapiens_hsa054161.12789088
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09881206
38MicroRNAs in cancer_Homo sapiens_hsa052061.08388360
39Non-homologous end-joining_Homo sapiens_hsa034501.08323620
40VEGF signaling pathway_Homo sapiens_hsa043701.07102780
41FoxO signaling pathway_Homo sapiens_hsa040681.07061718
42* Non-small cell lung cancer_Homo sapiens_hsa052231.06316046
43Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06314381
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.06215204
45Tuberculosis_Homo sapiens_hsa051521.05933283
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.05812741
47Prolactin signaling pathway_Homo sapiens_hsa049171.05132491
48Malaria_Homo sapiens_hsa051441.05112692
49Graft-versus-host disease_Homo sapiens_hsa053321.04391218
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03479290
51Renal cell carcinoma_Homo sapiens_hsa052111.01660567
52Shigellosis_Homo sapiens_hsa051310.99046915
53Acute myeloid leukemia_Homo sapiens_hsa052210.98754259
54Adherens junction_Homo sapiens_hsa045200.94976098
55Prion diseases_Homo sapiens_hsa050200.94811623
56Apoptosis_Homo sapiens_hsa042100.94729699
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94150437
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93666786
59Choline metabolism in cancer_Homo sapiens_hsa052310.92185761
60Amoebiasis_Homo sapiens_hsa051460.91816800
61* Small cell lung cancer_Homo sapiens_hsa052220.91625324
62Notch signaling pathway_Homo sapiens_hsa043300.90333847
63Herpes simplex infection_Homo sapiens_hsa051680.89881022
64Endometrial cancer_Homo sapiens_hsa052130.88573256
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.88261188
66TNF signaling pathway_Homo sapiens_hsa046680.87779299
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.87177458
68mTOR signaling pathway_Homo sapiens_hsa041500.87126808
69Type II diabetes mellitus_Homo sapiens_hsa049300.86451133
70Renin secretion_Homo sapiens_hsa049240.86361558
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.85219117
72* HTLV-I infection_Homo sapiens_hsa051660.84973633
73Salmonella infection_Homo sapiens_hsa051320.84565082
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.84145034
75Asthma_Homo sapiens_hsa053100.84136780
76Proteoglycans in cancer_Homo sapiens_hsa052050.83827011
77Insulin resistance_Homo sapiens_hsa049310.82870486
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82192242
79MAPK signaling pathway_Homo sapiens_hsa040100.81566612
80Autoimmune thyroid disease_Homo sapiens_hsa053200.81392797
81* Viral carcinogenesis_Homo sapiens_hsa052030.80803036
82Influenza A_Homo sapiens_hsa051640.80558967
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80178675
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79477080
85Rheumatoid arthritis_Homo sapiens_hsa053230.77901763
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77759432
87Hepatitis C_Homo sapiens_hsa051600.77376219
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76707377
89Systemic lupus erythematosus_Homo sapiens_hsa053220.76640095
90* Glioma_Homo sapiens_hsa052140.76577808
91* Epstein-Barr virus infection_Homo sapiens_hsa051690.74959998
92Focal adhesion_Homo sapiens_hsa045100.74702365
93Inositol phosphate metabolism_Homo sapiens_hsa005620.74032787
94Endocytosis_Homo sapiens_hsa041440.73910330
95Pertussis_Homo sapiens_hsa051330.73097204
96ErbB signaling pathway_Homo sapiens_hsa040120.72346578
97HIF-1 signaling pathway_Homo sapiens_hsa040660.71768944
98cAMP signaling pathway_Homo sapiens_hsa040240.71337625
99* Prostate cancer_Homo sapiens_hsa052150.71207214
100GnRH signaling pathway_Homo sapiens_hsa049120.71003185
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.69760217
102p53 signaling pathway_Homo sapiens_hsa041150.69543210
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69242791
104Antigen processing and presentation_Homo sapiens_hsa046120.69065558
105DNA replication_Homo sapiens_hsa030300.67868540
106Long-term potentiation_Homo sapiens_hsa047200.67413482
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66249891
108Type I diabetes mellitus_Homo sapiens_hsa049400.65735720
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64918217
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.64672829
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63727522
112Salivary secretion_Homo sapiens_hsa049700.63216738
113Lysine degradation_Homo sapiens_hsa003100.63090348
114Allograft rejection_Homo sapiens_hsa053300.62302711
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.60246505
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59951441
117* Cell cycle_Homo sapiens_hsa041100.59392306
118* Pathways in cancer_Homo sapiens_hsa052000.58788290
119Alcoholism_Homo sapiens_hsa050340.58586356
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.58198828
121Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56600997
122Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56003667

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