RASSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.01585112
2negative regulation of cell killing (GO:0031342)6.01585112
3positive thymic T cell selection (GO:0045059)4.59542457
4positive regulation of B cell differentiation (GO:0045579)4.54739380
5negative thymic T cell selection (GO:0045060)4.34687483
6negative T cell selection (GO:0043383)4.22328288
7regulation of gamma-delta T cell differentiation (GO:0045586)4.18903478
8regulation of gamma-delta T cell activation (GO:0046643)4.16008607
9negative regulation of erythrocyte differentiation (GO:0045647)4.15360696
10regulation of B cell differentiation (GO:0045577)4.07114540
11detection of bacterium (GO:0016045)3.95368789
12regulation of mast cell degranulation (GO:0043304)3.93807959
13leukocyte aggregation (GO:0070486)3.93674845
14response to interleukin-15 (GO:0070672)3.91651221
15detection of other organism (GO:0098543)3.85647956
16Arp2/3 complex-mediated actin nucleation (GO:0034314)3.82313690
17positive T cell selection (GO:0043368)3.79326062
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.72450643
19negative regulation of leukocyte mediated immunity (GO:0002704)3.70598454
20B cell receptor signaling pathway (GO:0050853)3.68682883
21thymic T cell selection (GO:0045061)3.66988788
22cellular response to interleukin-15 (GO:0071350)3.64284242
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.63043530
24regulation of mast cell activation involved in immune response (GO:0033006)3.59083588
25T cell migration (GO:0072678)3.54524924
26neutrophil activation involved in immune response (GO:0002283)3.53423088
27T cell selection (GO:0045058)3.49547363
28regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48135590
29positive regulation of granulocyte differentiation (GO:0030854)3.47532300
30negative regulation of T cell mediated immunity (GO:0002710)3.41123721
31regulation of leukocyte degranulation (GO:0043300)3.40104571
32negative regulation of innate immune response (GO:0045824)3.39483887
33regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.30040524
34regulation of natural killer cell mediated immunity (GO:0002715)3.30040524
35tolerance induction (GO:0002507)3.29237044
36cellular extravasation (GO:0045123)3.20445231
37regulation of T cell mediated cytotoxicity (GO:0001914)3.15561250
38response to muramyl dipeptide (GO:0032495)3.13803990
39response to interferon-beta (GO:0035456)3.13642077
40regulation of alpha-beta T cell proliferation (GO:0046640)3.12773309
41energy homeostasis (GO:0097009)3.11147587
42positive regulation of T cell mediated cytotoxicity (GO:0001916)3.09713900
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08654631
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.07080457
45myeloid cell activation involved in immune response (GO:0002275)3.04093431
46negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.03641693
47wound healing, spreading of epidermal cells (GO:0035313)3.01584003
48leukocyte degranulation (GO:0043299)2.99646176
49actin nucleation (GO:0045010)2.98882053
50G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.98680622
51respiratory burst (GO:0045730)2.98413883
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.96103019
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96023266
54response to host immune response (GO:0052572)2.96023266
55macrophage activation involved in immune response (GO:0002281)2.92807689
56positive regulation of mast cell activation (GO:0033005)2.91541160
57positive regulation of macrophage differentiation (GO:0045651)2.91156983
58detection of external biotic stimulus (GO:0098581)2.90417742
59antigen receptor-mediated signaling pathway (GO:0050851)2.89946049
60Peyers patch development (GO:0048541)2.87563952
61mucosal-associated lymphoid tissue development (GO:0048537)2.87563952
62megakaryocyte development (GO:0035855)2.87295961
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86524416
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86524416
65positive regulation of interleukin-8 secretion (GO:2000484)2.85115516
66mature B cell differentiation involved in immune response (GO:0002313)2.82685067
67regulation of interleukin-8 secretion (GO:2000482)2.82540882
68regulation of granulocyte differentiation (GO:0030852)2.81622941
69antigen processing and presentation via MHC class Ib (GO:0002475)2.80500676
70interferon-gamma production (GO:0032609)2.80029583
71regulation of interferon-beta biosynthetic process (GO:0045357)2.79862153
72regulation of leukocyte mediated cytotoxicity (GO:0001910)2.79086020
73negative regulation of interleukin-6 production (GO:0032715)2.78138619
74mast cell activation (GO:0045576)2.77715992
75chondrocyte proliferation (GO:0035988)2.75594205
76regulation of regulated secretory pathway (GO:1903305)2.74426225
77response to host defenses (GO:0052200)2.72473925
78response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.72473925
79response to host (GO:0075136)2.72473925
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.72149761
81response to peptidoglycan (GO:0032494)2.69876638
82regulation of necroptotic process (GO:0060544)2.68609370
83antigen processing and presentation of endogenous antigen (GO:0019883)2.64404849
84NIK/NF-kappaB signaling (GO:0038061)2.64233700
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.60291515
86wound healing, spreading of cells (GO:0044319)2.59342311
87immunoglobulin mediated immune response (GO:0016064)2.52919693
88cellular response to interferon-beta (GO:0035458)2.51898930
89regulation of T cell receptor signaling pathway (GO:0050856)2.51069070
90phagocytosis, engulfment (GO:0006911)2.48168610
91positive regulation of gamma-delta T cell activation (GO:0046645)2.47783796
92negative regulation of mast cell activation (GO:0033004)2.46634454
93regulation of dendritic cell antigen processing and presentation (GO:0002604)2.43314520
94positive regulation of keratinocyte differentiation (GO:0045618)2.41460952
95response to interferon-alpha (GO:0035455)2.40566829
96regulation of B cell receptor signaling pathway (GO:0050855)2.37868708
97regulation of antigen processing and presentation (GO:0002577)2.37432589
98type I interferon signaling pathway (GO:0060337)2.37407393
99cellular response to type I interferon (GO:0071357)2.37407393
100angiogenesis involved in wound healing (GO:0060055)2.36346371
101response to type I interferon (GO:0034340)2.34934655
102fibril organization (GO:0097435)2.34697039
103regulation of T cell tolerance induction (GO:0002664)2.32379440
104mature B cell differentiation (GO:0002335)2.31382119
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30331911
106neutrophil activation (GO:0042119)2.30048957
107regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.29197886
108regulation of type B pancreatic cell apoptotic process (GO:2000674)2.28672491
109ribosomal small subunit assembly (GO:0000028)2.27050379
110regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.26474943
111B cell mediated immunity (GO:0019724)2.25514498
112facial nerve structural organization (GO:0021612)2.22324983
113myeloid dendritic cell activation (GO:0001773)2.22268259
114negative regulation of phagocytosis (GO:0050765)2.21597412
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.20557749
116regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.20500155
117regulation of vitamin D biosynthetic process (GO:0060556)2.20395454
118I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.19840837
119response to protozoan (GO:0001562)2.19422558
120positive regulation of natural killer cell differentiation (GO:0032825)2.18826918
121tyrosine phosphorylation of STAT protein (GO:0007260)2.18448127
122regulation of cell proliferation involved in kidney development (GO:1901722)2.17782470
123response to progesterone (GO:0032570)2.16700436
124phospholipid scrambling (GO:0017121)2.16634729
125hepatocyte apoptotic process (GO:0097284)2.13966227
126negative regulation of interleukin-12 production (GO:0032695)2.13509833
127negative regulation of nitric oxide biosynthetic process (GO:0045019)2.11513285
128mRNA transcription from RNA polymerase II promoter (GO:0042789)2.09125757
129production of molecular mediator involved in inflammatory response (GO:0002532)2.07881906
130membrane raft organization (GO:0031579)2.07881585
131regulation of mast cell activation (GO:0033003)2.07689524
132positive regulation by symbiont of host defense response (GO:0052509)2.07523706
133modulation by symbiont of host defense response (GO:0052031)2.07523706
134modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.07523706
135modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.07523706
136positive regulation by organism of defense response of other organism involved in symbiotic interact2.07523706
137modulation by symbiont of host immune response (GO:0052553)2.07523706
138nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.06365536
139regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.05609783
140cellular defense response (GO:0006968)2.05404435
141regulation of RIG-I signaling pathway (GO:0039535)2.04706470
142vascular endothelial growth factor signaling pathway (GO:0038084)2.04017381
143positive regulation of hair cycle (GO:0042635)2.03615092
144positive regulation of hair follicle development (GO:0051798)2.03615092
145regulation of metalloenzyme activity (GO:0048552)2.03223486
146definitive hemopoiesis (GO:0060216)2.02669745
147regulation of cellular extravasation (GO:0002691)2.01622694
148regulation of macrophage differentiation (GO:0045649)2.01509124
149defense response to protozoan (GO:0042832)2.00731977
150cyclooxygenase pathway (GO:0019371)2.00489888
151regulation of T cell migration (GO:2000404)2.00174071
152sprouting angiogenesis (GO:0002040)2.00094332
153T cell apoptotic process (GO:0070231)1.99138685
154antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)1.98541169
155protein heterotetramerization (GO:0051290)1.97739119
156granulocyte activation (GO:0036230)1.96197630
157superoxide anion generation (GO:0042554)1.95215414
158regulation of tolerance induction (GO:0002643)1.95079750
159negative regulation of viral genome replication (GO:0045071)1.95003575
160substrate-dependent cell migration (GO:0006929)1.94898740
161positive regulation of antigen processing and presentation (GO:0002579)1.94522520
162positive regulation of monocyte chemotaxis (GO:0090026)1.94450426
163dendritic cell migration (GO:0036336)1.94104664
164regulation of vitamin metabolic process (GO:0030656)1.93892731

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.59332656
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.80122090
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.33509510
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.58146856
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.52099617
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.47661000
7VDR_21846776_ChIP-Seq_THP-1_Human3.26006385
8E2F7_22180533_ChIP-Seq_HELA_Human3.21604173
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99350887
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.91617747
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.88981980
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.88234512
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.80938278
14* MYC_22102868_ChIP-Seq_BL_Human2.71810976
15SCL_19346495_ChIP-Seq_HPC-7_Human2.61480305
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.42675817
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33793056
18CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.27651044
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.26485242
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25374272
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.23910313
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23749243
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.22112697
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.22064713
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20182426
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.16356485
27MAF_26560356_Chip-Seq_TH2_Human2.12818908
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.08884495
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07408142
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.06498095
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.02878422
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96962019
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.91668909
34* SPI1_23547873_ChIP-Seq_NB4_Human1.90832997
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87667467
36SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87021445
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87021445
38ELK1_19687146_ChIP-ChIP_HELA_Human1.86129180
39SPI1_23127762_ChIP-Seq_K562_Human1.84641931
40* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83462581
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.75117690
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73831736
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.73480615
44CIITA_25753668_ChIP-Seq_RAJI_Human1.73429726
45FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.69157112
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68619491
47* KDM2B_26808549_Chip-Seq_DND41_Human1.68115151
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67661040
49* MYB_26560356_Chip-Seq_TH2_Human1.64115441
50GATA3_27048872_Chip-Seq_THYMUS_Human1.59193517
51* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57452309
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.56258711
53GATA2_21666600_ChIP-Seq_HMVEC_Human1.53591700
54BCL6_27268052_Chip-Seq_Bcells_Human1.53493864
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53312119
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51526103
57LXR_22292898_ChIP-Seq_THP-1_Human1.49825031
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48849347
59STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48841487
60WT1_19549856_ChIP-ChIP_CCG9911_Human1.48272734
61* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.47747933
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.47622479
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47352636
64GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.46035708
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.43999920
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43441397
67* ELF1_20517297_ChIP-Seq_JURKAT_Human1.40323920
68GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40223669
69CJUN_26792858_Chip-Seq_BT549_Human1.39942447
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.39352541
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.37497974
72* MYB_26560356_Chip-Seq_TH1_Human1.37492041
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36002811
74HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34504727
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34092050
76* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.33672301
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.32076934
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31859987
79PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31075472
80BCOR_27268052_Chip-Seq_Bcells_Human1.30931611
81* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.29284771
82PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28934555
83GATA1_19941826_ChIP-Seq_K562_Human1.27651722
84GABP_17652178_ChIP-ChIP_JURKAT_Human1.27418069
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26820915
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26729943
87EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24903031
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23476588
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22510134
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22360608
91SOX2_20726797_ChIP-Seq_SW620_Human1.22323548
92JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21587813
93RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21440175
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.21013936
95* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20741588
96* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19419437
97NCOR1_26117541_ChIP-Seq_K562_Human1.18344339
98BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18283049
99P68_20966046_ChIP-Seq_HELA_Human1.17327507
100EST1_17652178_ChIP-ChIP_JURKAT_Human1.16394659
101GATA3_26560356_Chip-Seq_TH2_Human1.15800411
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14539086
103THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13902786
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13472259
105RUNX_20019798_ChIP-Seq_JUKART_Human1.13049020
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.13038276
107ESR1_21235772_ChIP-Seq_MCF-7_Human1.12374927
108SA1_27219007_Chip-Seq_ERYTHROID_Human1.09756433
109* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09742419
110* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07692844
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07155744
112HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07041619
113KDM2B_26808549_Chip-Seq_JURKAT_Human1.05572888
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05294423
115BRD4_25478319_ChIP-Seq_HGPS_Human1.04872852
116CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04743694
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03038715
118CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02466618
119PU_27001747_Chip-Seq_BMDM_Mouse1.02336100
120* MAF_26560356_Chip-Seq_TH1_Human1.01538446
121* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01412893
122ELK3_25401928_ChIP-Seq_HUVEC_Human1.00301472
123CTCF_26484167_Chip-Seq_Bcells_Mouse1.00019253
124P300_27268052_Chip-Seq_Bcells_Human0.98097225
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97974744
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96451819
127PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95821409
128* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95362042
129GATA1_22025678_ChIP-Seq_K562_Human0.93825854
130TP53_18474530_ChIP-ChIP_U2OS_Human0.93804245
131GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93168372
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.93072952
133* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92897892
134VDR_24763502_ChIP-Seq_THP-1_Human0.92682779
135FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92398132
136IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92054860
137* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91835191
138SPI1_20517297_ChIP-Seq_HL60_Human0.91796628
139CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.90164526
140* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.89440189
141UTX_26944678_Chip-Seq_JUKART_Human0.89142162
142ERG_20887958_ChIP-Seq_HPC-7_Mouse0.88830117
143VDR_23849224_ChIP-Seq_CD4+_Human0.88762470
144TP63_19390658_ChIP-ChIP_HaCaT_Human0.88014946
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87138210
146VDR_24787735_ChIP-Seq_THP-1_Human0.86870146
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86738657
148CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85204604
149TFEB_21752829_ChIP-Seq_HELA_Human0.84398002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.35719748
2MP0001835_abnormal_antigen_presentation2.50842474
3MP0008438_abnormal_cutaneous_collagen2.46092800
4MP0003303_peritoneal_inflammation2.37771783
5MP0002148_abnormal_hypersensitivity_rea2.24473640
6MP0003191_abnormal_cellular_cholesterol2.20456320
7MP0009785_altered_susceptibility_to2.18469291
8MP0003436_decreased_susceptibility_to2.16928915
9MP0003941_abnormal_skin_development2.11073469
10MP0002396_abnormal_hematopoietic_system2.07253934
11MP0003172_abnormal_lysosome_physiology2.00738432
12MP0002009_preneoplasia1.95909035
13MP0003279_aneurysm1.90321345
14MP0005000_abnormal_immune_tolerance1.89853771
15MP0002166_altered_tumor_susceptibility1.79997923
16MP0003566_abnormal_cell_adhesion1.78505947
17MP0000685_abnormal_immune_system1.78265307
18MP0002006_tumorigenesis1.76561859
19MP0003763_abnormal_thymus_physiology1.75357823
20MP0005275_abnormal_skin_tensile1.74794347
21MP0002419_abnormal_innate_immunity1.74760368
22MP0005257_abnormal_intraocular_pressure1.74605239
23MP0001533_abnormal_skeleton_physiology1.73263525
24MP0005025_abnormal_response_to1.72544323
25MP0005058_abnormal_lysosome_morphology1.70032004
26MP0003828_pulmonary_edema1.68125415
27MP0001853_heart_inflammation1.66300081
28MP0000858_altered_metastatic_potential1.65967092
29MP0002452_abnormal_antigen_presenting1.63875668
30MP0002405_respiratory_system_inflammati1.62226692
31MP0003950_abnormal_plasma_membrane1.59116308
32MP0003448_altered_tumor_morphology1.57065911
33MP0004808_abnormal_hematopoietic_stem1.56040156
34MP0002132_abnormal_respiratory_system1.54282904
35MP0008007_abnormal_cellular_replicative1.54189971
36MP0005503_abnormal_tendon_morphology1.53881044
37MP0001790_abnormal_immune_system1.53806011
38MP0005387_immune_system_phenotype1.53806011
39MP0002060_abnormal_skin_morphology1.53566142
40MP0002723_abnormal_immune_serum1.52149732
41MP0002420_abnormal_adaptive_immunity1.51569365
42MP0001819_abnormal_immune_cell1.51199979
43MP0005671_abnormal_response_to1.49745385
44MP0003656_abnormal_erythrocyte_physiolo1.49413245
45MP0001800_abnormal_humoral_immune1.48511144
46MP0001879_abnormal_lymphatic_vessel1.48268700
47MP0002933_joint_inflammation1.47039488
48MP0005023_abnormal_wound_healing1.43461170
49MP0006054_spinal_hemorrhage1.43333777
50MP0008469_abnormal_protein_level1.42383137
51MP0001545_abnormal_hematopoietic_system1.41521529
52MP0005397_hematopoietic_system_phenotyp1.41521529
53MP0003091_abnormal_cell_migration1.41252349
54MP0005390_skeleton_phenotype1.39631092
55MP0005075_abnormal_melanosome_morpholog1.37935135
56MP0008260_abnormal_autophagy1.36989670
57MP0010368_abnormal_lymphatic_system1.33406346
58MP0009333_abnormal_splenocyte_physiolog1.29729144
59MP0000465_gastrointestinal_hemorrhage1.28081797
60MP0002877_abnormal_melanocyte_morpholog1.27636258
61MP0010155_abnormal_intestine_physiology1.27490589
62MP0004947_skin_inflammation1.26446536
63MP0004272_abnormal_basement_membrane1.26083473
64MP0001986_abnormal_taste_sensitivity1.24969890
65MP0001542_abnormal_bone_strength1.22900167
66MP0000490_abnormal_crypts_of1.20280887
67MP0001243_abnormal_dermal_layer1.20173026
68MP0002398_abnormal_bone_marrow1.19964176
69MP0003806_abnormal_nucleotide_metabolis1.19544654
70MP0000343_altered_response_to1.18311234
71MP0002163_abnormal_gland_morphology1.17498739
72MP0000767_abnormal_smooth_muscle1.16911690
73MP0004510_myositis1.16671710
74MP0010352_gastrointestinal_tract_polyps1.16087931
75MP0001958_emphysema1.15597216
76MP0008057_abnormal_DNA_replication1.14868251
77MP0001851_eye_inflammation1.13563783
78MP0000716_abnormal_immune_system1.11824491
79MP0005164_abnormal_response_to1.09931022
80MP0002998_abnormal_bone_remodeling1.09722501
81MP0000015_abnormal_ear_pigmentation1.09493756
82MP0005451_abnormal_body_composition1.08306578
83MP0005310_abnormal_salivary_gland1.07316846
84MP0002722_abnormal_immune_system1.05770428
85MP0009278_abnormal_bone_marrow1.05555763
86MP0005508_abnormal_skeleton_morphology1.03552715
87MP0003693_abnormal_embryo_hatching1.02906437
88MP0001873_stomach_inflammation1.02812657
89MP0000689_abnormal_spleen_morphology1.01252782
90MP0001845_abnormal_inflammatory_respons1.01004826
91MP0001216_abnormal_epidermal_layer0.96967187
92MP0002429_abnormal_blood_cell0.96644450
93* MP0009763_increased_sensitivity_to0.96216951
94MP0005464_abnormal_platelet_physiology0.95737993
95* MP0002019_abnormal_tumor_incidence0.95027232
96MP0004381_abnormal_hair_follicle0.94124724
97MP0004782_abnormal_surfactant_physiolog0.93191965
98MP0000372_irregular_coat_pigmentation0.92941728
99MP0000703_abnormal_thymus_morphology0.92859250
100MP0009840_abnormal_foam_cell0.92456879
101MP0003075_altered_response_to0.89543139
102MP0003183_abnormal_peptide_metabolism0.86047296
103MP0002098_abnormal_vibrissa_morphology0.86011912
104MP0003795_abnormal_bone_structure0.85380200
105MP0003453_abnormal_keratinocyte_physiol0.83776510
106MP0000604_amyloidosis0.83263449
107MP0009379_abnormal_foot_pigmentation0.82726481
108MP0009250_abnormal_appendicular_skeleto0.81443343
109MP0009765_abnormal_xenobiotic_induced0.79277745
110MP0002295_abnormal_pulmonary_circulatio0.79223251
111MP0004883_abnormal_blood_vessel0.78819283
112MP0003300_gastrointestinal_ulcer0.78694125
113MP0008004_abnormal_stomach_pH0.78366936
114MP0000249_abnormal_blood_vessel0.78194445
115MP0001188_hyperpigmentation0.77793356
116MP0006082_CNS_inflammation0.76651666
117MP0003866_abnormal_defecation0.75624300
118MP0003943_abnormal_hepatobiliary_system0.75491638
119MP0009764_decreased_sensitivity_to0.74321573
120MP0009384_cardiac_valve_regurgitation0.73151818
121MP0001663_abnormal_digestive_system0.67275455
122* MP0005166_decreased_susceptibility_to0.57172530
123MP0006036_abnormal_mitochondrial_physio0.55607826
124MP0003786_premature_aging0.55310241
125MP0002138_abnormal_hepatobiliary_system0.54812594
126MP0005319_abnormal_enzyme/_coenzyme0.53155348
127MP0008874_decreased_physiological_sensi0.52552941
128MP0005584_abnormal_enzyme/coenzyme_acti0.50619901
129MP0003045_fibrosis0.49350428
130MP0009931_abnormal_skin_appearance0.49041145
131MP0000681_abnormal_thyroid_gland0.45402878
132MP0005083_abnormal_biliary_tract0.45258809
133* MP0008873_increased_physiological_sensi0.44936812
134MP0000609_abnormal_liver_physiology0.43401066
135MP0005174_abnormal_tail_pigmentation0.42565545

Predicted human phenotypes

RankGene SetZ-score
1Panhypogammaglobulinemia (HP:0003139)4.30206577
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.21456499
3Prostate neoplasm (HP:0100787)4.10421516
4Premature rupture of membranes (HP:0001788)3.80173067
5Meningitis (HP:0001287)3.79689535
6Prolonged bleeding time (HP:0003010)3.65964339
7Myositis (HP:0100614)3.61088177
8T lymphocytopenia (HP:0005403)3.58851682
9Recurrent cutaneous fungal infections (HP:0011370)3.52979196
10Chronic mucocutaneous candidiasis (HP:0002728)3.52979196
11Agammaglobulinemia (HP:0004432)3.46461219
12Encephalitis (HP:0002383)3.45872560
13Abnormality of T cells (HP:0002843)3.41737660
14Abnormality of T cell number (HP:0011839)3.41559787
15Gastrointestinal infarctions (HP:0005244)3.38900155
16Recurrent skin infections (HP:0001581)3.28426006
17Epistaxis (HP:0000421)3.20517323
18Recurrent abscess formation (HP:0002722)3.16484441
19Elevated erythrocyte sedimentation rate (HP:0003565)3.14012501
20Increased IgE level (HP:0003212)3.13440984
21Orchitis (HP:0100796)3.13300687
22Autoimmune hemolytic anemia (HP:0001890)3.12678187
23Eczematoid dermatitis (HP:0000976)3.08176622
24Chest pain (HP:0100749)3.08174230
25Severe combined immunodeficiency (HP:0004430)3.05795733
26Inflammation of the large intestine (HP:0002037)3.03312884
27Gastrointestinal inflammation (HP:0004386)3.03268606
28Abnormality of T cell physiology (HP:0011840)2.99752273
29Optic neuritis (HP:0100653)2.99221712
30Retrobulbar optic neuritis (HP:0100654)2.99221712
31Abnormality of the heme biosynthetic pathway (HP:0010472)2.94295773
32Spontaneous hematomas (HP:0007420)2.94102389
33Syringomyelia (HP:0003396)2.89992293
34Spinal cord lesions (HP:0100561)2.89992293
35Recurrent gram-negative bacterial infections (HP:0005420)2.85086189
36Urticaria (HP:0001025)2.80068672
37Protrusio acetabuli (HP:0003179)2.78586775
38Atrophic scars (HP:0001075)2.74669118
39Colitis (HP:0002583)2.68545256
40Abnormality of the prostate (HP:0008775)2.59618852
41Recurrent bacterial skin infections (HP:0005406)2.58203169
42Upper limb muscle weakness (HP:0003484)2.54052748
43Aortic dissection (HP:0002647)2.50553097
44Gingival bleeding (HP:0000225)2.49947605
45Distal lower limb muscle weakness (HP:0009053)2.49812084
46Vertebral compression fractures (HP:0002953)2.49426162
47Cervical subluxation (HP:0003308)2.48175835
48Stomatitis (HP:0010280)2.47437904
49Hemoptysis (HP:0002105)2.46837534
50Hypochromic anemia (HP:0001931)2.46643644
51Increased serum ferritin (HP:0003281)2.43775902
52Hepatosplenomegaly (HP:0001433)2.43461944
53IgG deficiency (HP:0004315)2.43100696
54Gingivitis (HP:0000230)2.42753122
55Combined immunodeficiency (HP:0005387)2.40349450
56Pulmonary artery stenosis (HP:0004415)2.32357329
57Lymphopenia (HP:0001888)2.31323274
58Arterial thrombosis (HP:0004420)2.30248761
59Episodic fever (HP:0001954)2.30072155
60Recurrent bronchitis (HP:0002837)2.29962434
61Dysostosis multiplex (HP:0000943)2.28175426
62Soft skin (HP:0000977)2.27417751
63Abnormality of iron homeostasis (HP:0011031)2.26385547
64Stomach cancer (HP:0012126)2.25610880
65Purpura (HP:0000979)2.25131881
66Petechiae (HP:0000967)2.24455640
67Increased cerebral lipofuscin (HP:0011813)2.22117872
68Osteolytic defects of the hand bones (HP:0009699)2.19839389
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.19839389
70Acute hepatic failure (HP:0006554)2.19450479
71Hypertensive crisis (HP:0100735)2.19016983
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.18605589
73Papilloma (HP:0012740)2.18113628
74Verrucae (HP:0200043)2.18113628
75Hypochromic microcytic anemia (HP:0004840)2.14641429
76Granulocytopenia (HP:0001913)2.14428431
77Aplastic anemia (HP:0001915)2.13678735
78Abnormality of glycolipid metabolism (HP:0010969)2.13142685
79Abnormality of liposaccharide metabolism (HP:0010968)2.13142685
80Abnormality of glycosphingolipid metabolism (HP:0004343)2.13142685
81Anhidrosis (HP:0000970)2.12597015
82Mediastinal lymphadenopathy (HP:0100721)2.12380126
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.12062154
84Sepsis (HP:0100806)2.11801948
85Pulmonary infiltrates (HP:0002113)2.10707238
86Eosinophilia (HP:0001880)2.09923809
87Vacuolated lymphocytes (HP:0001922)2.09297943
88Abnormality of the pleura (HP:0002103)2.07665722
89Skin rash (HP:0000988)2.03943143
90Pulmonary embolism (HP:0002204)2.03934671
91Microcytic anemia (HP:0001935)2.02886464
92Mesomelia (HP:0003027)2.01348345
93Chronic diarrhea (HP:0002028)2.00657841
94Anorexia (HP:0002039)1.99556244
95Short nail (HP:0001799)1.96350330
96Patchy hypopigmentation of hair (HP:0011365)1.94650891
97Congenital, generalized hypertrichosis (HP:0004540)1.93778856
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93446943
99Recurrent fungal infections (HP:0002841)1.93001329
100Thrombocytosis (HP:0001894)1.92602429
101Peritonitis (HP:0002586)1.91965761
102Hypoproteinemia (HP:0003075)1.91304087
103Glomerulopathy (HP:0100820)1.91136955
104Impaired platelet aggregation (HP:0003540)1.90789162
105Abnormal platelet function (HP:0011869)1.90789162
106Autoimmune thrombocytopenia (HP:0001973)1.90574820
107Leukocytosis (HP:0001974)1.90385242
108Increased density of long bones (HP:0006392)1.90180928
109Spinal rigidity (HP:0003306)1.90159890
110Chronic otitis media (HP:0000389)1.89927227
111Wormian bones (HP:0002645)1.89311104
112Abnormality of the distal phalanges of the toes (HP:0010182)1.89305313
113Abnormality of dentin (HP:0010299)1.88728512
114Recurrent viral infections (HP:0004429)1.87512469
115Keratoconjunctivitis sicca (HP:0001097)1.86110538
116Aortic aneurysm (HP:0004942)1.85183914
117Abnormality of macrophages (HP:0004311)1.82607015
118Vasculitis (HP:0002633)1.81760621
119Muscle fiber atrophy (HP:0100295)1.80548506
120Chromsome breakage (HP:0040012)1.80135539
121Increased connective tissue (HP:0009025)1.79996320
122White forelock (HP:0002211)1.79694031
123Reticulocytopenia (HP:0001896)1.77134698
124Increased IgM level (HP:0003496)1.76529987
125Abnormality of eosinophils (HP:0001879)1.76137538
126Abnormality of the renal collecting system (HP:0004742)1.76021068
127Absent frontal sinuses (HP:0002688)1.75918008
128Chromosomal breakage induced by crosslinking agents (HP:0003221)1.73572556
129Biconcave vertebral bodies (HP:0004586)1.73570005
130Osteomyelitis (HP:0002754)1.72308420
131Fragile skin (HP:0001030)1.70749043
132Chronic obstructive pulmonary disease (HP:0006510)1.70111329
133Obstructive lung disease (HP:0006536)1.70111329
13411 pairs of ribs (HP:0000878)1.70052426
135Aplasia cutis congenita (HP:0001057)1.69901302
136Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.69761870
137B lymphocytopenia (HP:0010976)1.69225075
138Abnormality of B cell number (HP:0010975)1.69225075
139Xerostomia (HP:0000217)1.68018954
140IgM deficiency (HP:0002850)1.66803672
141Hypergammaglobulinemia (HP:0010702)1.66701384
142Submucous cleft hard palate (HP:0000176)1.66364016
143Lip pit (HP:0100267)1.66076909
144Distal lower limb amyotrophy (HP:0008944)1.65337483
145Recurrent pneumonia (HP:0006532)1.64594487
146Conical tooth (HP:0000698)1.63911315
147Keratoconjunctivitis (HP:0001096)1.63288684
148Thick nail (HP:0001805)1.63093677
149Skin ulcer (HP:0200042)1.62892102
150Neonatal short-limb short stature (HP:0008921)1.60550027
151Dilatation of the ascending aorta (HP:0005111)1.60396401
152Abnormality of the nasal mucosa (HP:0000433)1.58660362
153Natal tooth (HP:0000695)1.58579167
154Cellulitis (HP:0100658)1.57797049
155Right ventricular cardiomyopathy (HP:0011663)1.55935516
156Rough bone trabeculation (HP:0100670)1.53407257
157Pustule (HP:0200039)1.53249354
158Abnormality of the acetabulum (HP:0003170)1.53144310
159Short middle phalanx of the 5th finger (HP:0004220)1.52803824
160Aortic valve stenosis (HP:0001650)1.51984280
161Joint stiffness (HP:0001387)1.51004607

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.32932314
2MAP3K143.23246801
3PIM23.23216609
4FES3.16241227
5GRK62.93024833
6ERN12.80123132
7TAOK32.60807157
8MAP3K32.41672960
9ZAK2.33867013
10PRPF4B2.27243684
11MST1R2.23829047
12IRAK42.20119911
13BMPR1B2.11551804
14TESK22.08212778
15EPHA22.05971281
16TNK22.05567442
17TIE11.96985157
18TBK11.95686315
19TRPM71.95411343
20TEC1.92793297
21PIK3CA1.92698395
22RPS6KA41.91178457
23MAP3K131.85886942
24IKBKB1.85161975
25STK161.79869755
26TGFBR21.79532566
27KDR1.79011504
28IKBKE1.72540037
29MAP2K31.71401517
30TGFBR11.68559250
31NME21.65492471
32TXK1.65048886
33EPHA31.55908904
34BLK1.51588125
35KIT1.49050988
36TYK21.48412026
37MST41.46815198
38MAP4K11.43694070
39JAK31.43218842
40BTK1.34227734
41CHUK1.32081046
42MYLK1.29547590
43TESK11.26253158
44TTN1.24149082
45IRAK31.22671776
46CLK11.21517300
47PIM11.20766886
48BUB11.20678894
49ERBB31.17174594
50TAOK21.14535456
51BCKDK1.13724127
52NUAK11.12839674
53EIF2AK21.12730452
54PIK3CG1.09399466
55NEK91.08897215
56STK101.07134587
57VRK10.97537795
58JAK20.97453987
59RIPK10.96131334
60ITK0.94365219
61SIK20.94128360
62BCR0.92015399
63MARK30.91262358
64MAP2K20.91178564
65RPS6KB20.91077007
66MAPKAPK50.90202127
67PBK0.86756024
68MATK0.83726319
69PRKD20.83120405
70TRIB30.81516264
71PRKCQ0.79949472
72ZAP700.79493732
73MKNK10.78870164
74LCK0.76843130
75MAP3K10.76544027
76GRK70.76450095
77MAPKAPK30.74824224
78TSSK60.73790650
79MAPK120.73569577
80TAOK10.73067954
81BMPR20.72571039
82MAPK70.72360054
83EPHB20.71700153
84FGR0.69757417
85RPS6KA50.69169384
86DYRK30.68944406
87NLK0.66401858
88SIK30.66361223
89HIPK20.65125232
90HCK0.64977951
91PDK10.64798536
92MAP3K60.64657499
93MAPKAPK20.63841265
94RAF10.63746595
95FLT30.63406706
96MAPK110.62930458
97MAP3K70.62905112
98LYN0.62749574
99CDK80.61425936
100CDK30.61313655
101STK240.60849357
102SMG10.59423982
103MARK20.58352396
104JAK10.58186714
105MET0.56604626
106CSK0.56301715
107SYK0.55728493
108SCYL20.55029556
109LRRK20.54672566
110PTK2B0.52755577
111DMPK0.52659637
112STK40.52650945
113RPS6KC10.52153419
114RPS6KL10.52153419
115MAP3K110.51638231
116STK38L0.50569185
117CDK90.49464895
118BRD40.49026855
119DYRK1B0.48151534
120MKNK20.47921382
121GRK10.47612886
122MAP4K20.46746933
123CDC42BPA0.46236265
124CDK60.46210126
125TLK10.45423939
126NME10.44748519
127PDPK10.44742978
128YES10.44425978
129CDK70.44240875
130FER0.43881848
131EIF2AK30.43775455
132MOS0.43772761
133MAPK40.43688070
134CSF1R0.42948545
135FYN0.42875185
136IRAK20.42815411
137ACVR1B0.41039954
138ABL10.40815114
139MAP3K80.39630243
140ADRBK20.39394929
141MAP2K60.39165077
142MAPK150.39160332
143MAPK30.38886407
144MAP2K10.38193505
145RPS6KA60.37733882
146EPHB10.37230938
147IRAK10.37020287
148PTK60.36876827
149CDK190.36180668
150MAP3K50.35316540
151CAMKK20.32958856
152PRKD10.30988332
153RPS6KA20.27173136
154BMX0.26330907

Predicted pathways (KEGG)

RankGene SetZ-score
1Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.30196514
2Staphylococcus aureus infection_Homo sapiens_hsa051502.23124940
3Type I diabetes mellitus_Homo sapiens_hsa049402.22592341
4Leishmaniasis_Homo sapiens_hsa051402.06748401
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97192861
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.92172797
7Measles_Homo sapiens_hsa051621.83891697
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.71308243
9Primary immunodeficiency_Homo sapiens_hsa053401.69343601
10Malaria_Homo sapiens_hsa051441.65152902
11Shigellosis_Homo sapiens_hsa051311.64840981
12Hematopoietic cell lineage_Homo sapiens_hsa046401.60408597
13Proteasome_Homo sapiens_hsa030501.60034299
14Ribosome_Homo sapiens_hsa030101.59289428
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.58221402
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58085693
17Graft-versus-host disease_Homo sapiens_hsa053321.55751194
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.52814863
19p53 signaling pathway_Homo sapiens_hsa041151.51630200
20TNF signaling pathway_Homo sapiens_hsa046681.48619018
21Pertussis_Homo sapiens_hsa051331.47155411
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46536333
23Osteoclast differentiation_Homo sapiens_hsa043801.45388799
24Legionellosis_Homo sapiens_hsa051341.45269695
25Allograft rejection_Homo sapiens_hsa053301.44792884
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.35642846
27ECM-receptor interaction_Homo sapiens_hsa045121.35463719
28Herpes simplex infection_Homo sapiens_hsa051681.33862153
29DNA replication_Homo sapiens_hsa030301.32974418
30Apoptosis_Homo sapiens_hsa042101.31424991
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31159466
32Homologous recombination_Homo sapiens_hsa034401.29562622
33Toxoplasmosis_Homo sapiens_hsa051451.28974365
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26305059
35Small cell lung cancer_Homo sapiens_hsa052221.22061920
36Salmonella infection_Homo sapiens_hsa051321.20126120
37Influenza A_Homo sapiens_hsa051641.18080570
38Non-homologous end-joining_Homo sapiens_hsa034501.16777247
39Rheumatoid arthritis_Homo sapiens_hsa053231.16516523
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.13302286
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12400646
42Antigen processing and presentation_Homo sapiens_hsa046121.12084047
43Protein export_Homo sapiens_hsa030601.09636237
44Hepatitis B_Homo sapiens_hsa051611.08760726
45Autoimmune thyroid disease_Homo sapiens_hsa053201.07860498
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05715673
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01936827
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.01484175
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01098132
50Lysosome_Homo sapiens_hsa041420.99726666
51Jak-STAT signaling pathway_Homo sapiens_hsa046300.99425842
52HTLV-I infection_Homo sapiens_hsa051660.98643540
53Other glycan degradation_Homo sapiens_hsa005110.96713615
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96455525
55RNA polymerase_Homo sapiens_hsa030200.96154194
56Phagosome_Homo sapiens_hsa041450.96045564
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94740729
58RNA degradation_Homo sapiens_hsa030180.94390695
59B cell receptor signaling pathway_Homo sapiens_hsa046620.94316757
60Base excision repair_Homo sapiens_hsa034100.93767320
61Asthma_Homo sapiens_hsa053100.92861515
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92364954
63Focal adhesion_Homo sapiens_hsa045100.92276841
64Epstein-Barr virus infection_Homo sapiens_hsa051690.92243728
65Fanconi anemia pathway_Homo sapiens_hsa034600.91089494
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91051766
67T cell receptor signaling pathway_Homo sapiens_hsa046600.90355935
68Mismatch repair_Homo sapiens_hsa034300.89074824
69Adherens junction_Homo sapiens_hsa045200.88709009
70Pyrimidine metabolism_Homo sapiens_hsa002400.88061878
71Cell cycle_Homo sapiens_hsa041100.87106711
72Hepatitis C_Homo sapiens_hsa051600.86082362
73Tuberculosis_Homo sapiens_hsa051520.85779287
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79404128
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79402364
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77244953
77* Non-small cell lung cancer_Homo sapiens_hsa052230.76564472
78Chronic myeloid leukemia_Homo sapiens_hsa052200.76095020
79Viral carcinogenesis_Homo sapiens_hsa052030.75725282
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75298410
81Viral myocarditis_Homo sapiens_hsa054160.75002996
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74471498
83Platelet activation_Homo sapiens_hsa046110.73963985
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70686882
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70387969
86Endocytosis_Homo sapiens_hsa041440.69747461
87Sphingolipid metabolism_Homo sapiens_hsa006000.69702883
88TGF-beta signaling pathway_Homo sapiens_hsa043500.68977448
89Pancreatic cancer_Homo sapiens_hsa052120.68428225
90Nucleotide excision repair_Homo sapiens_hsa034200.68111584
91Proteoglycans in cancer_Homo sapiens_hsa052050.67792722
92* Bladder cancer_Homo sapiens_hsa052190.66088494
93African trypanosomiasis_Homo sapiens_hsa051430.65571742
94Spliceosome_Homo sapiens_hsa030400.65298077
95Arachidonic acid metabolism_Homo sapiens_hsa005900.64934301
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62937372
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61743600
98VEGF signaling pathway_Homo sapiens_hsa043700.60933921
99Acute myeloid leukemia_Homo sapiens_hsa052210.59197164
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59138248
101* MicroRNAs in cancer_Homo sapiens_hsa052060.59053709
102Prostate cancer_Homo sapiens_hsa052150.58460568
103Amoebiasis_Homo sapiens_hsa051460.58273348
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57731200
105Regulation of autophagy_Homo sapiens_hsa041400.57061968
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56103203
107HIF-1 signaling pathway_Homo sapiens_hsa040660.55947059
108Basal transcription factors_Homo sapiens_hsa030220.55621011
109* Pathways in cancer_Homo sapiens_hsa052000.54821447
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.52829314
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52353974
112Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51150001
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50855516
114Chemokine signaling pathway_Homo sapiens_hsa040620.50731673
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50658614
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.50544125
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50492369
118Melanoma_Homo sapiens_hsa052180.48274123
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.44877542
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.44009283
121Notch signaling pathway_Homo sapiens_hsa043300.35749146
122Prolactin signaling pathway_Homo sapiens_hsa049170.35048705
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.34590288
124Pentose phosphate pathway_Homo sapiens_hsa000300.34548413
125MAPK signaling pathway_Homo sapiens_hsa040100.33657603
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.33240803
127Colorectal cancer_Homo sapiens_hsa052100.33060417
128Systemic lupus erythematosus_Homo sapiens_hsa053220.30087645
129Inositol phosphate metabolism_Homo sapiens_hsa005620.29782627
130mTOR signaling pathway_Homo sapiens_hsa041500.29432378
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27396528
132Choline metabolism in cancer_Homo sapiens_hsa052310.26643364
133Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26205766
134Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23610752
135FoxO signaling pathway_Homo sapiens_hsa040680.21599008
136Insulin resistance_Homo sapiens_hsa049310.18581113

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