RASL11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RASL11A is a member of the small GTPase protein family with a high degree of similarity to RAS (see HRAS, MIM 190020) proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerulus development (GO:0032835)9.09768320
2surfactant homeostasis (GO:0043129)7.38130288
3chemical homeostasis within a tissue (GO:0048875)6.18955636
4regulation of vitamin D biosynthetic process (GO:0060556)5.88814003
5vascular endothelial growth factor signaling pathway (GO:0038084)5.35745721
6endothelial cell chemotaxis (GO:0035767)5.32675550
7regulation of vitamin metabolic process (GO:0030656)5.24397139
8regulation of cytokine secretion involved in immune response (GO:0002739)5.03941186
9kidney mesenchyme development (GO:0072074)5.03265889
10coronary vasculature morphogenesis (GO:0060977)4.97311133
11lymph vessel development (GO:0001945)4.96949334
12metanephric mesenchyme development (GO:0072075)4.95961067
13regulation of glomerular filtration (GO:0003093)4.86123375
14positive regulation of heat generation (GO:0031652)4.79493853
15regulation of fever generation (GO:0031620)4.78677357
16regulation of chronic inflammatory response (GO:0002676)4.63734306
17regulation of axon guidance (GO:1902667)4.62450048
18branching involved in labyrinthine layer morphogenesis (GO:0060670)4.52907270
19positive regulation of chemokine biosynthetic process (GO:0045080)4.52568270
20regulation of T-helper 1 cell differentiation (GO:0045625)4.40617202
21regulation of podosome assembly (GO:0071801)4.34096580
22virion attachment to host cell (GO:0019062)4.33175888
23adhesion of symbiont to host cell (GO:0044650)4.33175888
24negative regulation of axon guidance (GO:1902668)4.31216771
25lymphangiogenesis (GO:0001946)4.30554546
26positive regulation of p38MAPK cascade (GO:1900745)4.27978697
27activation of MAPKKK activity (GO:0000185)4.25730667
28regulation of axon extension involved in axon guidance (GO:0048841)4.21270985
29regulation of membrane protein ectodomain proteolysis (GO:0051043)4.20914441
30epithelial cell differentiation involved in kidney development (GO:0035850)4.20224389
31positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.19878972
32cell migration involved in sprouting angiogenesis (GO:0002042)4.17413876
33protein heterotrimerization (GO:0070208)4.15721290
34lung vasculature development (GO:0060426)4.11637554
35regulation of chemokine biosynthetic process (GO:0045073)4.05207679
36negative regulation of interleukin-12 production (GO:0032695)4.03751140
37lipopolysaccharide-mediated signaling pathway (GO:0031663)3.99733068
38negative regulation of nitric oxide biosynthetic process (GO:0045019)3.97820837
39response to peptidoglycan (GO:0032494)3.94746303
40renal system process involved in regulation of blood volume (GO:0001977)3.93818947
41regulation of mononuclear cell migration (GO:0071675)3.87780063
42adhesion of symbiont to host (GO:0044406)3.82894672
43endothelium development (GO:0003158)3.80212503
44wound healing, spreading of epidermal cells (GO:0035313)3.76810593
45axon extension involved in axon guidance (GO:0048846)3.70909717
46neuron projection extension involved in neuron projection guidance (GO:1902284)3.70909717
47mesodermal cell differentiation (GO:0048333)3.67940465
48glycosphingolipid catabolic process (GO:0046479)3.67652424
49cell adhesion mediated by integrin (GO:0033627)3.65949132
50cellular response to type I interferon (GO:0071357)3.63028357
51type I interferon signaling pathway (GO:0060337)3.63028357
52regulation of heat generation (GO:0031650)3.60485978
53vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.59896911
54cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.58918688
55regulation of nitric oxide biosynthetic process (GO:0045428)3.57361039
56NIK/NF-kappaB signaling (GO:0038061)3.56847276
57response to type I interferon (GO:0034340)3.56703448
58negative regulation of axon extension involved in axon guidance (GO:0048843)3.55644271
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.51645674
60regulation of p38MAPK cascade (GO:1900744)3.50509800
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48379724
62negative regulation of cytokine production involved in immune response (GO:0002719)3.47884679
63myeloid dendritic cell differentiation (GO:0043011)3.44097110
64oligosaccharide catabolic process (GO:0009313)3.44093355
65venous blood vessel morphogenesis (GO:0048845)3.43002236
66regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42812666
67retina vasculature morphogenesis in camera-type eye (GO:0061299)3.42123658
68respiratory tube development (GO:0030323)3.41525978
69immunoglobulin mediated immune response (GO:0016064)3.41465447
70ureteric bud development (GO:0001657)3.41344336
71positive regulation of nitric oxide biosynthetic process (GO:0045429)3.40389178
72regulation of interferon-alpha production (GO:0032647)3.38091992
73branching involved in salivary gland morphogenesis (GO:0060445)3.37996185
74patterning of blood vessels (GO:0001569)3.33501073
75macrophage activation involved in immune response (GO:0002281)3.31581512
76germ cell migration (GO:0008354)3.31329448
77glycolipid catabolic process (GO:0019377)3.28747777
78regulation of heterotypic cell-cell adhesion (GO:0034114)3.28415495
79positive regulation of endothelial cell apoptotic process (GO:2000353)3.28070415
80germinal center formation (GO:0002467)3.27396520
81diaphragm development (GO:0060539)3.26617939
82mesonephric tubule development (GO:0072164)3.26224849
83positive regulation of NF-kappaB import into nucleus (GO:0042346)3.24177276
84negative regulation of lipid storage (GO:0010888)3.23031999
85endothelial cell morphogenesis (GO:0001886)3.22161424
86dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22047355
87monocyte chemotaxis (GO:0002548)3.21580364
88cell proliferation involved in metanephros development (GO:0072203)3.21276259
89mesonephric epithelium development (GO:0072163)3.20875597
90regulation of immunoglobulin secretion (GO:0051023)3.20469795
91renal filtration (GO:0097205)3.20104124
92low-density lipoprotein particle clearance (GO:0034383)3.13462230
93eosinophil chemotaxis (GO:0048245)3.13433870
94response to protozoan (GO:0001562)3.11876603
95positive regulation of metanephros development (GO:0072216)3.11461761
96cell migration involved in heart development (GO:0060973)3.10501743
97regulation of interleukin-8 biosynthetic process (GO:0045414)3.10261195
98T-helper 1 type immune response (GO:0042088)3.09812986
99regulation of T-helper 2 cell differentiation (GO:0045628)3.08113584
100regulation of tight junction assembly (GO:2000810)3.07350767
101positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.05928796
102sprouting angiogenesis (GO:0002040)3.05287897
103blood vessel endothelial cell migration (GO:0043534)3.03165175
104cell proliferation involved in kidney development (GO:0072111)3.00723312
105negative regulation of homotypic cell-cell adhesion (GO:0034111)3.00502759
106regulation of cholesterol storage (GO:0010885)2.99737678
107neural crest cell development (GO:0014032)2.96155517
108mesenchymal cell development (GO:0014031)2.96060651
109cellular response to lipopolysaccharide (GO:0071222)2.94883565
110interferon-gamma-mediated signaling pathway (GO:0060333)2.93955245
111positive regulation of acute inflammatory response (GO:0002675)2.93797676
112smooth muscle tissue development (GO:0048745)2.92456148
113protein localization to endosome (GO:0036010)2.88812723
114defense response to protozoan (GO:0042832)2.88726473
115platelet-derived growth factor receptor signaling pathway (GO:0048008)2.88678663
116negative regulation of amino acid transport (GO:0051956)2.88103548
117regulation of NF-kappaB import into nucleus (GO:0042345)2.87511643
118positive regulation of interleukin-6 production (GO:0032755)2.87257887
119renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.86051796
120membrane lipid catabolic process (GO:0046466)2.85488158
121negative regulation of chondrocyte differentiation (GO:0032331)2.85247167
122lung-associated mesenchyme development (GO:0060484)2.84836570
123regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.83892385
124epithelial cell-cell adhesion (GO:0090136)2.83714136
125sphingolipid catabolic process (GO:0030149)2.83135699
126positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.81991740
127chondrocyte proliferation (GO:0035988)2.81942812
128ceramide catabolic process (GO:0046514)2.81904221
129skeletal muscle organ development (GO:0060538)2.81222051
130cellular response to molecule of bacterial origin (GO:0071219)2.80689790
131positive regulation of cell adhesion mediated by integrin (GO:0033630)2.80450184
132neutrophil activation involved in immune response (GO:0002283)2.80304687
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79493177
134paraxial mesoderm development (GO:0048339)2.78744884
135wound healing, spreading of cells (GO:0044319)2.78075099
136regulation of metanephros development (GO:0072215)2.77491585
137induction of positive chemotaxis (GO:0050930)2.76591255
138myeloid dendritic cell activation (GO:0001773)2.74825695
139positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.74693482
140positive regulation of natural killer cell differentiation (GO:0032825)2.74569336
141negative regulation of production of molecular mediator of immune response (GO:0002701)2.74350642
142eosinophil migration (GO:0072677)2.74275960
143regulation of inflammatory response to antigenic stimulus (GO:0002861)2.73733888
144negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.72861529
145cell differentiation involved in kidney development (GO:0061005)2.72759002
146regulation of type I interferon-mediated signaling pathway (GO:0060338)2.71724886
147vasculogenesis (GO:0001570)2.71472588
148positive regulation of male gonad development (GO:2000020)2.70736837
149muscle cell migration (GO:0014812)2.70322941
150hippo signaling (GO:0035329)2.69626402
151collagen fibril organization (GO:0030199)2.68915620
152dendritic cell differentiation (GO:0097028)2.68702687
153metanephros development (GO:0001656)2.68003175
154regulation of type 2 immune response (GO:0002828)2.67705661
155interferon-gamma secretion (GO:0072643)2.66868406
156positive regulation of type 2 immune response (GO:0002830)2.66057831
157regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.65881760
158mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.65819887
159positive regulation of vascular permeability (GO:0043117)2.65052565
160cyclooxygenase pathway (GO:0019371)2.64819504
161lung alveolus development (GO:0048286)2.64121744
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63369741
163gap junction assembly (GO:0016264)2.63263701
164positive regulation of transcription factor import into nucleus (GO:0042993)2.62457374
165artery morphogenesis (GO:0048844)2.61498770
166chronic inflammatory response (GO:0002544)2.61145464
167regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61111415
168activation of Rac GTPase activity (GO:0032863)2.60947974
169ovulation (GO:0030728)2.60731465
170positive regulation of epithelial to mesenchymal transition (GO:0010718)2.60604142
171mesenchyme development (GO:0060485)2.58388437
172modulation of growth of symbiont involved in interaction with host (GO:0044144)2.57732993
173regulation of growth of symbiont in host (GO:0044126)2.57732993
174negative regulation of growth of symbiont in host (GO:0044130)2.57732993
175negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.57732993
176regulation of heart morphogenesis (GO:2000826)2.57324799
177regulation of dendritic cell antigen processing and presentation (GO:0002604)2.56030646
178basement membrane organization (GO:0071711)2.55822718
179mesenchymal to epithelial transition (GO:0060231)2.55679471
180cellular response to nicotine (GO:0071316)2.55435358
181response to muramyl dipeptide (GO:0032495)2.55271276
182regulation of interleukin-6 production (GO:0032675)2.54992067
183regulation of cell proliferation involved in kidney development (GO:1901722)2.54623663
184granulocyte activation (GO:0036230)2.53122538
185mature B cell differentiation involved in immune response (GO:0002313)2.51283221
186regulation of interleukin-12 production (GO:0032655)2.51157913
187positive regulation of natural killer cell activation (GO:0032816)2.50996808
188positive regulation of humoral immune response (GO:0002922)2.50038157
189positive regulation of interferon-alpha production (GO:0032727)2.50007932
190keratan sulfate catabolic process (GO:0042340)2.48751442
191negative regulation of myeloid cell apoptotic process (GO:0033033)2.48670117
192polarized epithelial cell differentiation (GO:0030859)2.48597485
193regulation of glomerulus development (GO:0090192)2.47068316
194Notch signaling involved in heart development (GO:0061314)2.47001979
195kidney epithelium development (GO:0072073)2.46970452
196mesonephros development (GO:0001823)2.46223714
197glomerular visceral epithelial cell development (GO:0072015)15.0204667
198glomerular epithelial cell development (GO:0072310)13.2746062
199glomerular basement membrane development (GO:0032836)11.5124335

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.24062271
2CLOCK_20551151_ChIP-Seq_293T_Human4.34450914
3WT1_19549856_ChIP-ChIP_CCG9911_Human4.23904552
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.93540963
5RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.82253682
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.75948072
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.63185825
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.57987140
9ESR1_21235772_ChIP-Seq_MCF-7_Human3.48330940
10NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.33398306
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.24374053
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.04904112
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.82491282
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.78140172
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73400364
16KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.67069611
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.67069611
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.67069611
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.64685063
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.47348331
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.44688779
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.41384831
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.40416924
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38902357
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.32599752
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.31025240
27RNF2_18974828_ChIP-Seq_MESCs_Mouse2.20817868
28EZH2_18974828_ChIP-Seq_MESCs_Mouse2.20817868
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20090739
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.17969688
31MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13362790
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11668825
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08230312
34ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.08205359
35SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.07743281
36* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06955078
37TP53_20018659_ChIP-ChIP_R1E_Mouse2.04529443
38HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04333756
39VDR_21846776_ChIP-Seq_THP-1_Human2.01137928
40EP300_21415370_ChIP-Seq_HL-1_Mouse1.99026360
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98982214
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98430622
43PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.97489051
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94713569
45EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.93849532
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.91269273
47SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.90871930
48STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83927328
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82622876
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.81732889
51MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81038709
52VDR_24763502_ChIP-Seq_THP-1_Human1.80349135
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78600215
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.77611448
55LXR_22292898_ChIP-Seq_THP-1_Human1.73508006
56FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72784866
57CJUN_26792858_Chip-Seq_BT549_Human1.72460231
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.72092805
59* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.71863810
60BRD4_25478319_ChIP-Seq_HGPS_Human1.70547199
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70425148
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.70109390
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68966456
64FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68167998
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66447902
66* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63497936
67SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63019042
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59726908
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.53390895
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.52361398
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.52097469
72VDR_24787735_ChIP-Seq_THP-1_Human1.51964844
73JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51059437
74RXR_22158963_ChIP-Seq_LIVER_Mouse1.50037223
75* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47917616
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.47437216
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45247494
78RACK7_27058665_Chip-Seq_MCF-7_Human1.44032083
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.42724539
80TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.40930657
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.40837655
82ISL1_27105846_Chip-Seq_CPCs_Mouse1.40170529
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.37550533
84TP53_18474530_ChIP-ChIP_U2OS_Human1.37158798
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36535004
86EZH2_22144423_ChIP-Seq_EOC_Human1.36117544
87E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35991447
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33369352
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32748705
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31343662
91TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30798890
92KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30067960
93SPI1_23127762_ChIP-Seq_K562_Human1.28590642
94RNF2_27304074_Chip-Seq_ESCs_Mouse1.28274770
95CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25741822
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25330772
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25330772
98KDM2B_26808549_Chip-Seq_DND41_Human1.24639855
99TCF7_22412390_ChIP-Seq_EML_Mouse1.23834392
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23006358
101STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22364108
102RUNX1_22412390_ChIP-Seq_EML_Mouse1.22173672
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22121146
104* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21587262
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21540847
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20918148
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19452751
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18335182
109FOXO3_23340844_ChIP-Seq_DLD1_Human1.18277741
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17442503
111CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17279090
112AHR_22903824_ChIP-Seq_MCF-7_Human1.17255727
113LXR_22158963_ChIP-Seq_LIVER_Mouse1.16735881
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16168979
115BP1_19119308_ChIP-ChIP_Hs578T_Human1.16126134
116KDM2B_26808549_Chip-Seq_K562_Human1.13736392
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.13337296
118ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12665757
119SOX2_20726797_ChIP-Seq_SW620_Human1.12234318
120* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.11842929
121MAF_26560356_Chip-Seq_TH1_Human1.10919400
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10703104
123STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10611945
124POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10092105
125ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.09870661
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09774713
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09193728
128GATA1_19941826_ChIP-Seq_K562_Human1.08835363
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07721124
130MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.07611722
131SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06523093
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.06444092
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06231754
134RING1B_27294783_Chip-Seq_ESCs_Mouse1.06197888
135SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05955014
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05129609
137ESR1_20079471_ChIP-ChIP_T-47D_Human1.04266873
138STAT1_20625510_ChIP-Seq_HELA_Human1.04091782
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03436348
140GATA2_21666600_ChIP-Seq_HMVEC_Human1.02195371
141GATA1_19941827_ChIP-Seq_MEL_Mouse1.02023606
142EZH2_27294783_Chip-Seq_ESCs_Mouse1.01719727
143UBF1/2_26484160_Chip-Seq_HMECs_Human1.01681380
144* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01410340
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01050338
146CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00011516
147SPI1_23547873_ChIP-Seq_NB4_Human0.99781816
148STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99146607
149TP53_16413492_ChIP-PET_HCT116_Human0.98647532
150SCL_19346495_ChIP-Seq_HPC-7_Human0.98545482
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.98460766
152CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97879432
153JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97800300
154VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97698043
155PU_27001747_Chip-Seq_BMDM_Mouse0.97452458
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97427351
157KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97385375
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96936431
159SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96443765
160NANOG_16153702_ChIP-ChIP_HESCs_Human0.95593898
161SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94713170
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94675061
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92556006
164UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92245780
165STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92062263
166SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91773544
167BCOR_27268052_Chip-Seq_Bcells_Human0.91673039
168LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91148611
169PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91047151
170THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90044209
171CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89861573

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation5.69525800
2MP0005623_abnormal_meninges_morphology4.24822190
3MP0010368_abnormal_lymphatic_system4.20709129
4MP0004272_abnormal_basement_membrane4.20083861
5MP0001879_abnormal_lymphatic_vessel3.86434491
6MP0005058_abnormal_lysosome_morphology3.46662642
7MP0009384_cardiac_valve_regurgitation3.44994685
8MP0006082_CNS_inflammation3.42827215
9MP0002139_abnormal_hepatobiliary_system3.39845093
10MP0003279_aneurysm3.34934626
11MP0003724_increased_susceptibility_to3.25446037
12MP0003436_decreased_susceptibility_to3.23682708
13MP0009840_abnormal_foam_cell3.19177828
14MP0004510_myositis3.14707444
15MP0002148_abnormal_hypersensitivity_rea3.01797578
16MP0010030_abnormal_orbit_morphology2.86645924
17MP0001958_emphysema2.86081320
18MP0009785_altered_susceptibility_to2.85532268
19MP0008438_abnormal_cutaneous_collagen2.84026551
20MP0008004_abnormal_stomach_pH2.69396268
21MP0000537_abnormal_urethra_morphology2.68893964
22MP0003300_gastrointestinal_ulcer2.64463589
23MP0003942_abnormal_urinary_system2.58324098
24MP0002295_abnormal_pulmonary_circulatio2.45021855
25MP0005503_abnormal_tendon_morphology2.44627001
26MP0003941_abnormal_skin_development2.20402249
27MP0005451_abnormal_body_composition2.20070718
28MP0009764_decreased_sensitivity_to2.19004128
29MP0003075_altered_response_to2.17777469
30MP0001533_abnormal_skeleton_physiology2.15416853
31MP0005000_abnormal_immune_tolerance2.12693007
32MP0000534_abnormal_ureter_morphology2.09088976
33MP0005387_immune_system_phenotype2.08748425
34MP0001790_abnormal_immune_system2.08748425
35MP0004084_abnormal_cardiac_muscle2.07694926
36MP0003705_abnormal_hypodermis_morpholog2.05144475
37MP0005025_abnormal_response_to2.02227221
38MP0001835_abnormal_antigen_presentation1.99522376
39MP0002419_abnormal_innate_immunity1.98362757
40MP0003453_abnormal_keratinocyte_physiol1.97569791
41MP0000343_altered_response_to1.94055184
42MP0010155_abnormal_intestine_physiology1.92291669
43MP0004947_skin_inflammation1.89376892
44MP0002254_reproductive_system_inflammat1.83001297
45MP0009250_abnormal_appendicular_skeleto1.82224358
46MP0000516_abnormal_urinary_system1.78370240
47MP0005367_renal/urinary_system_phenotyp1.78370240
48MP0000678_abnormal_parathyroid_gland1.75599510
49MP0003191_abnormal_cellular_cholesterol1.72462739
50MP0000604_amyloidosis1.64573642
51MP0005671_abnormal_response_to1.61801390
52MP0009053_abnormal_anal_canal1.59759442
53MP0003566_abnormal_cell_adhesion1.59716029
54MP0001542_abnormal_bone_strength1.58805642
55MP0003448_altered_tumor_morphology1.58531742
56MP0003091_abnormal_cell_migration1.57922900
57MP0001853_heart_inflammation1.57884673
58MP0005508_abnormal_skeleton_morphology1.57795297
59MP0002723_abnormal_immune_serum1.55058397
60MP0002452_abnormal_antigen_presenting1.54458975
61MP0002332_abnormal_exercise_endurance1.53883756
62MP0001299_abnormal_eye_distance/1.52291032
63MP0001845_abnormal_inflammatory_respons1.51606603
64MP0003385_abnormal_body_wall1.51255050
65MP0005166_decreased_susceptibility_to1.51152789
66MP0000767_abnormal_smooth_muscle1.46642042
67MP0002998_abnormal_bone_remodeling1.45292966
68MP0006138_congestive_heart_failure1.44633104
69MP0001545_abnormal_hematopoietic_system1.44312525
70MP0005397_hematopoietic_system_phenotyp1.44312525
71MP0005595_abnormal_vascular_smooth1.44263787
72MP0008469_abnormal_protein_level1.43851431
73MP0003172_abnormal_lysosome_physiology1.42192994
74MP0001800_abnormal_humoral_immune1.42192217
75MP0004134_abnormal_chest_morphology1.38056137
76MP0003115_abnormal_respiratory_system1.37599205
77MP0003123_paternal_imprinting1.34271475
78MP0003806_abnormal_nucleotide_metabolis1.32163507
79MP0005171_absent_coat_pigmentation1.31957678
80MP0005275_abnormal_skin_tensile1.31720765
81MP0005023_abnormal_wound_healing1.28941370
82MP0000762_abnormal_tongue_morphology1.28796535
83MP0002135_abnormal_kidney_morphology1.24882633
84MP0002877_abnormal_melanocyte_morpholog1.24032143
85MP0005666_abnormal_adipose_tissue1.23940058
86MP0001614_abnormal_blood_vessel1.22771922
87MP0001177_atelectasis1.21147311
88MP0000230_abnormal_systemic_arterial1.20874395
89MP0002128_abnormal_blood_circulation1.19461121
90MP0003937_abnormal_limbs/digits/tail_de1.18746149
91MP0002420_abnormal_adaptive_immunity1.18563847
92MP0001819_abnormal_immune_cell1.18402396
93MP0005310_abnormal_salivary_gland1.17969401
94MP0003690_abnormal_glial_cell1.17520064
95MP0003786_premature_aging1.16876664
96MP0001663_abnormal_digestive_system1.16773361
97MP0008995_early_reproductive_senescence1.16629684
98MP0002133_abnormal_respiratory_system1.16350328
99MP0005388_respiratory_system_phenotype1.16350328
100MP0005165_increased_susceptibility_to1.15734520
101MP0000685_abnormal_immune_system1.15703612
102MP0000049_abnormal_middle_ear1.14506888
103MP0000163_abnormal_cartilage_morphology1.14228706
104MP0002925_abnormal_cardiovascular_devel1.14059241
105MP0002405_respiratory_system_inflammati1.13624208
106MP0005390_skeleton_phenotype1.13272232
107MP0004883_abnormal_blood_vessel1.12276893
108MP0005164_abnormal_response_to1.09292351
109MP0009333_abnormal_splenocyte_physiolog1.08568709
110MP0000013_abnormal_adipose_tissue1.08091782
111MP0004185_abnormal_adipocyte_glucose1.06531980
112MP0003935_abnormal_craniofacial_develop1.06242048
113MP0003329_amyloid_beta_deposits1.05417534
114MP0002932_abnormal_joint_morphology1.04575225
115MP0009278_abnormal_bone_marrow1.04002654
116MP0004133_heterotaxia1.02939901
117MP0003119_abnormal_digestive_system1.00798041
118MP0002138_abnormal_hepatobiliary_system0.99884815
119MP0002653_abnormal_ependyma_morphology0.99171704
120MP0005197_abnormal_uvea_morphology0.95179087
121MP0002136_abnormal_kidney_physiology0.94739647
122MP0001661_extended_life_span0.94618419
123MP0002009_preneoplasia0.94606258
124MP0003195_calcinosis0.94447373
125MP0005381_digestive/alimentary_phenotyp0.94090843
126MP0001175_abnormal_lung_morphology0.93906017
127MP0002233_abnormal_nose_morphology0.93742875
128MP0001501_abnormal_sleep_pattern0.93202844
129MP0008260_abnormal_autophagy0.92405639
130MP0003656_abnormal_erythrocyte_physiolo0.91654543
131MP0000428_abnormal_craniofacial_morphol0.91341020
132MP0004782_abnormal_surfactant_physiolog0.91219981
133MP0004036_abnormal_muscle_relaxation0.89954213
134MP0001270_distended_abdomen0.89825542
135MP0003755_abnormal_palate_morphology0.89792607
136MP0005076_abnormal_cell_differentiation0.89344321
137MP0005647_abnormal_sex_gland0.87724095
138MP0000733_abnormal_muscle_development0.87593164
139MP0001915_intracranial_hemorrhage0.87114473
140MP0010307_abnormal_tumor_latency0.83997692
141MP0005167_abnormal_blood-brain_barrier0.83668827
142MP0002113_abnormal_skeleton_development0.83347189
143MP0002115_abnormal_skeleton_extremities0.82588191
144MP0000432_abnormal_head_morphology0.82525454
145MP0001756_abnormal_urination0.80097933
146MP0003938_abnormal_ear_development0.79818649
147MP0010352_gastrointestinal_tract_polyps0.79568818
148MP0004484_altered_response_of0.79199549
149MP0004858_abnormal_nervous_system0.79110429
150MP0009763_increased_sensitivity_to0.79107662
151MP0005375_adipose_tissue_phenotype0.78896804
152MP0005257_abnormal_intraocular_pressure0.78149678
153MP0000003_abnormal_adipose_tissue0.78118442
154MP0000716_abnormal_immune_system0.77868914
155MP0003879_abnormal_hair_cell0.77301319
156MP0008874_decreased_physiological_sensi0.77244422
157MP0001784_abnormal_fluid_regulation0.76978746
158MP0000490_abnormal_crypts_of0.76828872
159MP0002127_abnormal_cardiovascular_syste0.76678200
160MP0003122_maternal_imprinting0.74913423
161MP0005464_abnormal_platelet_physiology0.74369186
162MP0005365_abnormal_bile_salt0.73080620
163MP0001286_abnormal_eye_development0.72922099
164MP0005377_hearing/vestibular/ear_phenot0.72704500
165MP0003878_abnormal_ear_physiology0.72704500
166MP0000858_altered_metastatic_potential0.71605689
167MP0002933_joint_inflammation0.71433798
168MP0006054_spinal_hemorrhage0.71283798
169MP0002896_abnormal_bone_mineralization0.70704563
170MP0005385_cardiovascular_system_phenoty0.70406864
171MP0001544_abnormal_cardiovascular_syste0.70406864
172MP0002116_abnormal_craniofacial_bone0.69819121
173MP0001873_stomach_inflammation0.69813207
174MP0002282_abnormal_trachea_morphology0.69806210
175MP0008775_abnormal_heart_ventricle0.68542210
176MP0005535_abnormal_body_temperature0.68452205
177MP0003795_abnormal_bone_structure0.67946540
178MP0003183_abnormal_peptide_metabolism0.66614095
179MP0009765_abnormal_xenobiotic_induced0.65293464
180MP0005319_abnormal_enzyme/_coenzyme0.65129579
181MP0000249_abnormal_blood_vessel0.65032878
182MP0001764_abnormal_homeostasis0.62218502
183MP0000609_abnormal_liver_physiology0.61230917
184MP0010234_abnormal_vibrissa_follicle0.61073766

Predicted human phenotypes

RankGene SetZ-score
1Mesangial abnormality (HP:0001966)8.03509684
2Abnormality of glycolipid metabolism (HP:0010969)6.77151186
3Abnormality of liposaccharide metabolism (HP:0010968)6.77151186
4Abnormality of glycosphingolipid metabolism (HP:0004343)6.77151186
5Focal segmental glomerulosclerosis (HP:0000097)6.47119994
6Abnormal albumin level (HP:0012116)5.86526662
7Hypoalbuminemia (HP:0003073)5.86526662
8Systemic lupus erythematosus (HP:0002725)5.36640770
9Glomerulosclerosis (HP:0000096)5.24023837
10Protrusio acetabuli (HP:0003179)4.67258898
11Loss of speech (HP:0002371)4.58473929
12Aortic aneurysm (HP:0004942)4.55538526
13Vacuolated lymphocytes (HP:0001922)4.54744738
14Premature rupture of membranes (HP:0001788)4.51052437
15Dysostosis multiplex (HP:0000943)4.46507883
16Stage 5 chronic kidney disease (HP:0003774)4.28164144
17Nuclear cataract (HP:0100018)4.24534574
18Disinhibition (HP:0000734)4.18442581
19Abnormality of macrophages (HP:0004311)4.13047094
20Persistence of primary teeth (HP:0006335)4.04047474
21Orchitis (HP:0100796)4.03745021
22Tubular atrophy (HP:0000092)3.95105302
23Ankle contracture (HP:0006466)3.87335197
24Retrobulbar optic neuritis (HP:0100654)3.75948139
25Optic neuritis (HP:0100653)3.75948139
26Increased cerebral lipofuscin (HP:0011813)3.65212972
27Neurofibrillary tangles (HP:0002185)3.64075689
28Abnormality of mucopolysaccharide metabolism (HP:0011020)3.56613457
29Abnormality of polysaccharide metabolism (HP:0011012)3.56613457
30Abnormality of glycosaminoglycan metabolism (HP:0004371)3.56613457
31Aortic dissection (HP:0002647)3.53763356
32Axonal loss (HP:0003447)3.51744900
33Myositis (HP:0100614)3.48800289
34Mucopolysacchariduria (HP:0008155)3.41369732
35Urinary glycosaminoglycan excretion (HP:0003541)3.41369732
36Mutism (HP:0002300)3.39777090
37Nephritis (HP:0000123)3.27239693
38Autoimmune thrombocytopenia (HP:0001973)3.26945080
39Broad metatarsal (HP:0001783)3.23287135
40Eczematoid dermatitis (HP:0000976)3.16604126
41Recurrent bacterial skin infections (HP:0005406)3.13711535
42Short hallux (HP:0010109)3.12380783
43Apathy (HP:0000741)3.11572526
44Abnormality of dentin (HP:0010299)3.10646349
45Complement deficiency (HP:0004431)3.09360002
46Malnutrition (HP:0004395)3.04464998
47Stomatitis (HP:0010280)3.00383132
48Diminished motivation (HP:0000745)2.95954574
49Amyloidosis (HP:0011034)2.94853902
50Increased density of long bones (HP:0006392)2.94397930
51Vascular tortuosity (HP:0004948)2.92952060
52Nausea (HP:0002018)2.91003838
53Aplasia/Hypoplasia of the hallux (HP:0008362)2.90728102
54Shallow orbits (HP:0000586)2.89888056
55Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.87972485
56Recurrent abscess formation (HP:0002722)2.84235524
57Abnormality of complement system (HP:0005339)2.78556958
58Neonatal respiratory distress (HP:0002643)2.75929563
59Increased neuronal autofluorescent lipopigment (HP:0002074)2.74292279
60Cerebral inclusion bodies (HP:0100314)2.69988695
61Tubulointerstitial fibrosis (HP:0005576)2.68794973
62Mediastinal lymphadenopathy (HP:0100721)2.65911616
63Keratoconjunctivitis sicca (HP:0001097)2.64330246
64Increased serum ferritin (HP:0003281)2.62742264
65Coronal craniosynostosis (HP:0004440)2.60247623
66Nephrotic syndrome (HP:0000100)2.60035499
67Arterial tortuosity (HP:0005116)2.58244089
68Progressive neurologic deterioration (HP:0002344)2.58126952
69Chondrocalcinosis (HP:0000934)2.57604978
70Prolonged neonatal jaundice (HP:0006579)2.54191582
71Cerebral aneurysm (HP:0004944)2.47940194
72Hyperparathyroidism (HP:0000843)2.42498931
73Wormian bones (HP:0002645)2.40885642
74Polycythemia (HP:0001901)2.40237552
75Humeroradial synostosis (HP:0003041)2.40022528
76Synostosis involving the elbow (HP:0003938)2.40022528
77Abnormality of Sharpey fibers (HP:0100685)2.39421176
78Metaphyseal irregularity (HP:0003025)2.36838480
79Vertebral compression fractures (HP:0002953)2.34513616
80Soft skin (HP:0000977)2.33972026
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.33885344
82Keratoconjunctivitis (HP:0001096)2.33378314
83Venous insufficiency (HP:0005293)2.31632710
84Pulmonary infiltrates (HP:0002113)2.27719173
85Neonatal short-limb short stature (HP:0008921)2.26769639
86Abnormality of the pulmonary veins (HP:0011718)2.22459102
87Recurrent gram-negative bacterial infections (HP:0005420)2.22140591
88Purpura (HP:0000979)2.21838888
89Asymmetric septal hypertrophy (HP:0001670)2.21520085
90Neuronal loss in central nervous system (HP:0002529)2.21397160
91Thin bony cortex (HP:0002753)2.20388637
92Aneurysm (HP:0002617)2.20301155
93Metaphyseal dysplasia (HP:0100255)2.20222673
94Corneal erosion (HP:0200020)2.19751033
95Upper motor neuron abnormality (HP:0002127)2.18702371
96Basal ganglia calcification (HP:0002135)2.18685089
97Myocardial infarction (HP:0001658)2.18222680
98Inappropriate behavior (HP:0000719)2.17981737
99Interstitial pulmonary disease (HP:0006530)2.15193645
100Increased IgM level (HP:0003496)2.14263463
101Bone pain (HP:0002653)2.13665224
102Lymphangioma (HP:0100764)2.13460505
103Dilatation of the ascending aorta (HP:0005111)2.12504546
104Aplasia involving bones of the upper limbs (HP:0009823)2.11297387
105Aplasia of the phalanges of the hand (HP:0009802)2.11297387
106Aplasia involving bones of the extremities (HP:0009825)2.11297387
107Follicular hyperkeratosis (HP:0007502)2.10583007
108Hypoplastic left heart (HP:0004383)2.09942331
109Hypoproteinemia (HP:0003075)2.09624023
110Vasculitis (HP:0002633)2.07526716
111Hypoplasia of the iris (HP:0007676)2.06634251
112Pterygium (HP:0001059)2.03238584
113Abnormality of iron homeostasis (HP:0011031)2.02881521
114Choanal stenosis (HP:0000452)2.01406984
115Parakeratosis (HP:0001036)2.00312166
116Breast hypoplasia (HP:0003187)1.99399876
117Proteinuria (HP:0000093)1.99101295
118Abnormality of monocarboxylic acid metabolism (HP:0010996)1.96923758
119Dementia (HP:0000726)1.96912639
120Hepatosplenomegaly (HP:0001433)1.96867787
121Shawl scrotum (HP:0000049)1.96708166
122Petechiae (HP:0000967)1.94830375
123Gangrene (HP:0100758)1.94212403
124Abnormality of the lumbar spine (HP:0100712)1.92881882
125Rapidly progressive (HP:0003678)1.92784900
126Venous abnormality (HP:0002624)1.92606581
127Hematuria (HP:0000790)1.91688261
128Glomerulonephritis (HP:0000099)1.90146111
129Thoracic kyphosis (HP:0002942)1.89734025
130Elevated erythrocyte sedimentation rate (HP:0003565)1.89361971
131Rectal prolapse (HP:0002035)1.89318704
132Bladder diverticulum (HP:0000015)1.89291018
133Stenosis of the external auditory canal (HP:0000402)1.88903371
134Personality changes (HP:0000751)1.88465468
135Hematochezia (HP:0002573)1.87952406
136Polyneuropathy (HP:0001271)1.87037736
137Atrophic scars (HP:0001075)1.85806513
138Mesomelia (HP:0003027)1.85595351
139Gingivitis (HP:0000230)1.84421365
140Emphysema (HP:0002097)1.83899016
141Metaphyseal cupping (HP:0003021)1.83723031
142Visceral angiomatosis (HP:0100761)1.83564046
143Down-sloping shoulders (HP:0200021)1.83187039
144Gastrointestinal stroma tumor (HP:0100723)1.82688505
145Zonular cataract (HP:0010920)1.80674452
146Femoral bowing (HP:0002980)1.80041192
147Thoracolumbar scoliosis (HP:0002944)1.79106298
148Absent toe (HP:0010760)1.78244891
149Anomalous pulmonary venous return (HP:0010772)1.77637906
150Absent eyelashes (HP:0000561)1.77355412
151Hip contracture (HP:0003273)1.77069711
152Pathologic fracture (HP:0002756)1.76825674
153Recurrent corneal erosions (HP:0000495)1.76380764
154Hemoptysis (HP:0002105)1.76233869
155Hypergammaglobulinemia (HP:0010702)1.75650014
156Broad hallux (HP:0010055)1.75395177
157Spinal rigidity (HP:0003306)1.75241065
158Broad toe (HP:0001837)1.74913046
159Acne (HP:0001061)1.74596219
160Peripheral demyelination (HP:0011096)1.74473201
161Hypercortisolism (HP:0001578)1.73773745
162Ovoid vertebral bodies (HP:0003300)1.73136054
163Cardiomegaly (HP:0001640)1.72348426
164Abnormality of the pericardium (HP:0001697)1.70643647
165Right ventricular cardiomyopathy (HP:0011663)1.69871423
166Polar cataract (HP:0010696)1.69292865
167Agnosia (HP:0010524)1.69254239
168Abnormality of the basal ganglia (HP:0002134)1.69094324
169Hemangiomatosis (HP:0007461)1.67830322
170Renal duplication (HP:0000075)1.67402101
171Arthralgia (HP:0002829)1.65725745
172Spondylolisthesis (HP:0003302)1.65722449
173Knee flexion contracture (HP:0006380)1.65696405
174Neoplasm of the lung (HP:0100526)1.65371818
175Achilles tendon contracture (HP:0001771)1.65307115
176Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64529474
177Selective tooth agenesis (HP:0001592)1.64511517
178Cervical subluxation (HP:0003308)1.64352833
179Short nail (HP:0001799)1.64336599
180Bronchomalacia (HP:0002780)1.63721644
181Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63696314
182Wrist flexion contracture (HP:0001239)1.62532721
183Heterochromia iridis (HP:0001100)1.59581003
184Biconcave vertebral bodies (HP:0004586)1.58918133
185Overgrowth (HP:0001548)1.57534580
186Advanced eruption of teeth (HP:0006288)1.56655448
187Pulmonary artery stenosis (HP:0004415)1.55063574
188Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53691217
189Short 1st metacarpal (HP:0010034)1.53691217
190Blue sclerae (HP:0000592)1.52729362
191Aqueductal stenosis (HP:0002410)1.52498765
192Preaxial foot polydactyly (HP:0001841)1.51300900
193Aplasia/Hypoplasia of the clavicles (HP:0006710)1.50945730
194Natal tooth (HP:0000695)1.50645275
195Narrow nasal bridge (HP:0000446)1.50147423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB25.78014341
2IRAK35.23856798
3MYLK4.44946818
4NME23.79961471
5AKT33.41071177
6WNK43.04287089
7GRK72.89225237
8MST42.87033055
9MAP3K142.78823855
10PAK42.70869080
11ERN12.69191641
12MAP3K32.64579569
13PAK32.61617300
14PDGFRA2.58907722
15TSSK62.58613782
16TBK12.47648107
17TIE12.41968863
18PRPF4B2.27938929
19TGFBR22.27804356
20LATS22.02177467
21PAK22.01276433
22MOS1.96446438
23STK38L1.95746304
24STK391.93110174
25TGFBR11.89381910
26MATK1.81660421
27IKBKB1.80849770
28OXSR11.80450660
29IRAK41.75494567
30KDR1.70989653
31IKBKE1.63577871
32TYK21.60053986
33CDC42BPA1.57128809
34FER1.56644356
35STK241.55177764
36RIPK11.47353170
37BLK1.39224797
38EPHA31.36287838
39PDGFRB1.35889536
40ZAK1.34867066
41TESK11.33179344
42BMPR21.32874691
43CHUK1.29340962
44LMTK21.28818228
45MAP3K11.27563976
46BUB11.24309007
47RIPK41.22849191
48CSK1.20484958
49MAP3K51.20034976
50MAPK151.18339002
51IRAK21.18161086
52FGR1.17028375
53MKNK21.14218464
54PTK2B1.11491887
55ACVR1B1.10918482
56ROCK11.10263059
57PLK31.08822420
58MAP4K11.08658290
59IRAK11.03166704
60LATS11.02842334
61CDK61.02212405
62TTN1.00792972
63CLK11.00786540
64BMX1.00522244
65LIMK10.99014783
66FGFR20.98488306
67JAK30.97869357
68SIK10.97615584
69BRAF0.95250709
70ILK0.94590841
71ZAP700.93146724
72MAP2K10.91239442
73DDR20.91002254
74MAP2K30.88906574
75ADRBK20.88677018
76STK100.87979344
77ICK0.86368554
78MAP3K130.82550114
79WEE10.79907505
80TAOK10.79366776
81FGFR10.75229063
82MST1R0.74700036
83MKNK10.74451284
84GSK3A0.74193686
85MAP2K20.74155941
86PTK20.73452989
87CDK30.71137114
88PLK20.70822768
89TAOK20.70797938
90TESK20.69888793
91KIT0.68868475
92ABL20.68550823
93NEK60.67898604
94TXK0.67728247
95ERBB30.67458766
96NUAK10.67016912
97CAMK2B0.66054728
98TYRO30.65046378
99JAK10.63099951
100LRRK20.62156811
101PNCK0.60779006
102JAK20.60296592
103MAP3K20.57458128
104HIPK20.55946554
105MELK0.55322848
106PRKCE0.54044901
107MAP3K110.53840423
108DYRK1B0.52925086
109MAP2K60.52636061
110LYN0.51853046
111PAK10.50896708
112PRKG20.50397938
113DYRK30.49969591
114STK30.47678573
115RPS6KA40.46584772
116INSR0.46241841
117PDPK10.45592319
118ERBB20.45398672
119CDK140.45379541
120MAPK40.45074140
121PIM20.44622362
122IGF1R0.43695672
123DAPK30.41744462
124DMPK0.41248275
125CAMK2G0.40459722
126CSF1R0.38924882
127PKN10.37288452
128PDK20.37201552
129CDK150.36516150
130RPS6KL10.36208770
131RPS6KC10.36208770
132MAPK90.35920562
133CDK120.35609104
134ALK0.35594617
135NTRK10.35360241
136EPHB10.35219797
137CDK180.34975429
138TRIB30.34455961
139SIK30.34392352
140PDK10.34247372
141MARK30.34181689
142VRK10.33766783
143EPHA20.32937390
144SYK0.32177031
145CDK11A0.32139460
146PRKAA20.32046584
147AURKB0.31032103
148GRK10.30342397
149PIK3CA0.30174187
150PRKD10.29974680
151MAP3K80.29337663
152KSR10.29300770
153ARAF0.28891090
154PIM10.28064500
155LCK0.26877058
156RPS6KA20.25817805
157ROCK20.25630899
158MAPKAPK20.25565340
159MAPK70.24442002
160MAP3K70.24006182
161MARK20.23926139
162CAMK1D0.23577116
163RPS6KA60.22269811
164HCK0.18429357

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.06176518
2Other glycan degradation_Homo sapiens_hsa005113.24230125
3Toll-like receptor signaling pathway_Homo sapiens_hsa046202.86022258
4Focal adhesion_Homo sapiens_hsa045102.82880939
5AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.59312311
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.55557617
7Small cell lung cancer_Homo sapiens_hsa052222.55404130
8Malaria_Homo sapiens_hsa051442.49166867
9Adherens junction_Homo sapiens_hsa045202.46200683
10Osteoclast differentiation_Homo sapiens_hsa043802.45137803
11Asthma_Homo sapiens_hsa053102.42204977
12Staphylococcus aureus infection_Homo sapiens_hsa051502.36106206
13Lysosome_Homo sapiens_hsa041422.29533520
14Axon guidance_Homo sapiens_hsa043602.27916728
15Allograft rejection_Homo sapiens_hsa053302.23929799
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.23748176
17Leishmaniasis_Homo sapiens_hsa051402.21281110
18Pertussis_Homo sapiens_hsa051332.19012261
19African trypanosomiasis_Homo sapiens_hsa051432.15655525
20Renin-angiotensin system_Homo sapiens_hsa046142.13437394
21Glycosaminoglycan degradation_Homo sapiens_hsa005312.10174923
22Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08928593
23Bladder cancer_Homo sapiens_hsa052192.01692965
24NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00917192
25Hippo signaling pathway_Homo sapiens_hsa043901.98856234
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98424932
27Amoebiasis_Homo sapiens_hsa051461.94833660
28Legionellosis_Homo sapiens_hsa051341.92571872
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.86961996
30Salmonella infection_Homo sapiens_hsa051321.80789027
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.76275954
32Tuberculosis_Homo sapiens_hsa051521.73214408
33Graft-versus-host disease_Homo sapiens_hsa053321.72912975
34Melanoma_Homo sapiens_hsa052181.71939546
35Circadian rhythm_Homo sapiens_hsa047101.69082325
36Dilated cardiomyopathy_Homo sapiens_hsa054141.68333087
37Proteoglycans in cancer_Homo sapiens_hsa052051.67866654
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.66753165
39Influenza A_Homo sapiens_hsa051641.65404087
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61803739
41Protein digestion and absorption_Homo sapiens_hsa049741.61673402
42Toxoplasmosis_Homo sapiens_hsa051451.61247147
43PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60347905
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.56400749
45TGF-beta signaling pathway_Homo sapiens_hsa043501.56095383
46Rap1 signaling pathway_Homo sapiens_hsa040151.54524806
47Pathways in cancer_Homo sapiens_hsa052001.52846396
48Sulfur metabolism_Homo sapiens_hsa009201.51690679
49Autoimmune thyroid disease_Homo sapiens_hsa053201.51465648
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49047857
51Prion diseases_Homo sapiens_hsa050201.48334784
52Prostate cancer_Homo sapiens_hsa052151.42852417
53Hepatitis C_Homo sapiens_hsa051601.39535526
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.39360149
55Basal cell carcinoma_Homo sapiens_hsa052171.39184308
56Tight junction_Homo sapiens_hsa045301.34157265
57MicroRNAs in cancer_Homo sapiens_hsa052061.33286987
58Renal cell carcinoma_Homo sapiens_hsa052111.29463991
59RNA polymerase_Homo sapiens_hsa030201.24222352
60p53 signaling pathway_Homo sapiens_hsa041151.24047265
61Notch signaling pathway_Homo sapiens_hsa043301.23582377
62Type I diabetes mellitus_Homo sapiens_hsa049401.22248617
63Gap junction_Homo sapiens_hsa045401.22187239
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19808059
65Leukocyte transendothelial migration_Homo sapiens_hsa046701.19761799
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.18838017
67Hedgehog signaling pathway_Homo sapiens_hsa043401.12558439
68Glioma_Homo sapiens_hsa052141.12414590
69Adipocytokine signaling pathway_Homo sapiens_hsa049201.11531176
70Herpes simplex infection_Homo sapiens_hsa051681.10501091
71Hematopoietic cell lineage_Homo sapiens_hsa046401.08918363
72Sphingolipid metabolism_Homo sapiens_hsa006001.08043454
73Jak-STAT signaling pathway_Homo sapiens_hsa046301.07519202
74Pancreatic cancer_Homo sapiens_hsa052121.03506568
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.01762276
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.00707974
77Cell cycle_Homo sapiens_hsa041101.00455316
78Wnt signaling pathway_Homo sapiens_hsa043100.99721393
79Melanogenesis_Homo sapiens_hsa049160.99358714
80HTLV-I infection_Homo sapiens_hsa051660.98892177
81Phagosome_Homo sapiens_hsa041450.98210493
82Viral myocarditis_Homo sapiens_hsa054160.95904615
83Hepatitis B_Homo sapiens_hsa051610.93550556
84Rheumatoid arthritis_Homo sapiens_hsa053230.93394032
85Complement and coagulation cascades_Homo sapiens_hsa046100.92469098
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90330097
87Spliceosome_Homo sapiens_hsa030400.88583946
88Antigen processing and presentation_Homo sapiens_hsa046120.88566915
89Measles_Homo sapiens_hsa051620.88556372
90Chemokine signaling pathway_Homo sapiens_hsa040620.87393382
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87034117
92HIF-1 signaling pathway_Homo sapiens_hsa040660.86637709
93B cell receptor signaling pathway_Homo sapiens_hsa046620.86016316
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84825817
95Estrogen signaling pathway_Homo sapiens_hsa049150.84718449
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84369557
97Ras signaling pathway_Homo sapiens_hsa040140.83408539
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81801808
99Renin secretion_Homo sapiens_hsa049240.78270283
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77985625
101cAMP signaling pathway_Homo sapiens_hsa040240.77042721
102Chronic myeloid leukemia_Homo sapiens_hsa052200.76766428
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75290545
104Galactose metabolism_Homo sapiens_hsa000520.75154169
105Prolactin signaling pathway_Homo sapiens_hsa049170.74698863
106Colorectal cancer_Homo sapiens_hsa052100.74646733
107Acute myeloid leukemia_Homo sapiens_hsa052210.74072986
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70667776
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70294955
110Fructose and mannose metabolism_Homo sapiens_hsa000510.70000411
111FoxO signaling pathway_Homo sapiens_hsa040680.68382963
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68242877
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68196233
114VEGF signaling pathway_Homo sapiens_hsa043700.68184921
115PPAR signaling pathway_Homo sapiens_hsa033200.66020736
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65297258
117N-Glycan biosynthesis_Homo sapiens_hsa005100.64816380
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64242035
119Platelet activation_Homo sapiens_hsa046110.63630486
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63539185
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63052411
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.61588283
123Thyroid cancer_Homo sapiens_hsa052160.61471306
124Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60723887
125TNF signaling pathway_Homo sapiens_hsa046680.60279429
126Glutathione metabolism_Homo sapiens_hsa004800.59341949
127Oxytocin signaling pathway_Homo sapiens_hsa049210.58893911
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58617742
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58375736
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.57957922
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56662149
132Type II diabetes mellitus_Homo sapiens_hsa049300.56422944
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56028694
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55427954
135Gastric acid secretion_Homo sapiens_hsa049710.55343609
136MAPK signaling pathway_Homo sapiens_hsa040100.53738493
137T cell receptor signaling pathway_Homo sapiens_hsa046600.52303409
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.51595515
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51551901
140RNA transport_Homo sapiens_hsa030130.51354257
141Non-small cell lung cancer_Homo sapiens_hsa052230.50627270
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.50375872
143Endometrial cancer_Homo sapiens_hsa052130.50343341
144Endocytosis_Homo sapiens_hsa041440.49806246
145Collecting duct acid secretion_Homo sapiens_hsa049660.49242270
146Insulin resistance_Homo sapiens_hsa049310.47976854
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.47882933
148Folate biosynthesis_Homo sapiens_hsa007900.47229550
149Basal transcription factors_Homo sapiens_hsa030220.46986101
150Circadian entrainment_Homo sapiens_hsa047130.46660211
151Proteasome_Homo sapiens_hsa030500.45353712
152Vibrio cholerae infection_Homo sapiens_hsa051100.45174258
153Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44681167
154Oocyte meiosis_Homo sapiens_hsa041140.43967007
155Calcium signaling pathway_Homo sapiens_hsa040200.43424584
156Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.43259149
157Shigellosis_Homo sapiens_hsa051310.42893776
158Mineral absorption_Homo sapiens_hsa049780.42546288
159Tryptophan metabolism_Homo sapiens_hsa003800.41353813
160Apoptosis_Homo sapiens_hsa042100.40363079
161Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39600202
162Epstein-Barr virus infection_Homo sapiens_hsa051690.38976661
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38874556
164Neurotrophin signaling pathway_Homo sapiens_hsa047220.36719120
165Cyanoamino acid metabolism_Homo sapiens_hsa004600.33132493
166Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31316786
167Systemic lupus erythematosus_Homo sapiens_hsa053220.25401076
168Viral carcinogenesis_Homo sapiens_hsa052030.21706063
169Vitamin digestion and absorption_Homo sapiens_hsa049770.19578399
170mTOR signaling pathway_Homo sapiens_hsa041500.16300293
171GnRH signaling pathway_Homo sapiens_hsa049120.15851620

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