RASGRP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.17803006
2endothelium development (GO:0003158)6.34023608
3vascular endothelial growth factor signaling pathway (GO:0038084)5.34613337
4behavioral response to nicotine (GO:0035095)5.33827375
5positive regulation of vasculogenesis (GO:2001214)5.08450932
6regulation of interferon-beta biosynthetic process (GO:0045357)4.87433516
7lymphangiogenesis (GO:0001946)4.75034291
8retina vasculature morphogenesis in camera-type eye (GO:0061299)4.45259129
9regulation of B cell receptor signaling pathway (GO:0050855)4.34967362
10cellular response to exogenous dsRNA (GO:0071360)4.23736426
11microglial cell activation (GO:0001774)4.16271029
12positive regulation of defense response to virus by host (GO:0002230)4.08868806
13I-kappaB phosphorylation (GO:0007252)4.02810791
14regulation of vasculogenesis (GO:2001212)4.01064756
15negative regulation of Rho protein signal transduction (GO:0035024)4.00531445
16fucose catabolic process (GO:0019317)3.98402530
17L-fucose metabolic process (GO:0042354)3.98402530
18L-fucose catabolic process (GO:0042355)3.98402530
19response to pheromone (GO:0019236)3.95887378
20blood vessel maturation (GO:0001955)3.91283732
21positive regulation by symbiont of host defense response (GO:0052509)3.86690625
22modulation by symbiont of host defense response (GO:0052031)3.86690625
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.86690625
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.86690625
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.86690625
26modulation by symbiont of host immune response (GO:0052553)3.86690625
27regulation of germinal center formation (GO:0002634)3.80434433
28indole-containing compound catabolic process (GO:0042436)3.79321367
29indolalkylamine catabolic process (GO:0046218)3.79321367
30tryptophan catabolic process (GO:0006569)3.79321367
31cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.76319882
32regulation of endothelial cell differentiation (GO:0045601)3.73939533
33kynurenine metabolic process (GO:0070189)3.72987071
34cytidine metabolic process (GO:0046087)3.66793285
35cytidine catabolic process (GO:0006216)3.66793285
36cytidine deamination (GO:0009972)3.66793285
37B cell receptor signaling pathway (GO:0050853)3.59006936
38surfactant homeostasis (GO:0043129)3.57491096
39peptidyl-tyrosine autophosphorylation (GO:0038083)3.55095025
40macrophage activation involved in immune response (GO:0002281)3.53154650
41cellular response to ATP (GO:0071318)3.49743131
42cellular extravasation (GO:0045123)3.44974625
43sprouting angiogenesis (GO:0002040)3.43198950
44substrate-dependent cell migration (GO:0006929)3.41615260
45vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.40472061
46histamine secretion (GO:0001821)3.38717772
47angiogenesis involved in wound healing (GO:0060055)3.38019214
48B cell proliferation (GO:0042100)3.37721962
49patterning of blood vessels (GO:0001569)3.34086584
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33910638
51endoderm formation (GO:0001706)3.33066304
52germinal center formation (GO:0002467)3.30927543
53macrophage activation (GO:0042116)3.30188268
54negative regulation of mast cell activation (GO:0033004)3.29076569
55indolalkylamine metabolic process (GO:0006586)3.27139827
56positive regulation of smooth muscle cell migration (GO:0014911)3.25548343
57basement membrane organization (GO:0071711)3.24352427
58endothelial cell differentiation (GO:0045446)3.21928037
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.20262202
60morphogenesis of an endothelium (GO:0003159)3.19506063
61endothelial tube morphogenesis (GO:0061154)3.19506063
62glomerular filtration (GO:0003094)3.18188998
63tryptophan metabolic process (GO:0006568)3.17728865
64protein localization to endosome (GO:0036010)3.15501854
65establishment of endothelial barrier (GO:0061028)3.14467903
66positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08639256
67positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.07377593
68endothelial cell morphogenesis (GO:0001886)3.06689781
69negative regulation of B cell proliferation (GO:0030889)3.05996401
70regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.05132861
71NAD biosynthetic process (GO:0009435)3.03801978
72DNA deamination (GO:0045006)3.00615112
73positive regulation of interferon-alpha production (GO:0032727)2.93208539
74purinergic nucleotide receptor signaling pathway (GO:0035590)2.93117897
75renal filtration (GO:0097205)2.92082333
76positive regulation of macrophage cytokine production (GO:0060907)2.89278987
77pathway-restricted SMAD protein phosphorylation (GO:0060389)2.87525397
78heart trabecula formation (GO:0060347)2.87476255
79regulation of MHC class I biosynthetic process (GO:0045343)2.87262366
80negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86899556
81negative regulation of telomere maintenance (GO:0032205)2.86635334
82regulation of defense response to virus by host (GO:0050691)2.86250296
83Rap protein signal transduction (GO:0032486)2.83150971
84ovulation from ovarian follicle (GO:0001542)2.82790843
85epithelial cell differentiation involved in kidney development (GO:0035850)2.82434360
86protein import into peroxisome matrix (GO:0016558)2.79283839
87regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.78745147
88response to laminar fluid shear stress (GO:0034616)2.76984882
89cellular response to interferon-beta (GO:0035458)2.76967764
90embryonic heart tube development (GO:0035050)2.76214305
91regulation of interferon-alpha production (GO:0032647)2.75840895
92alanine transport (GO:0032328)2.75307229
93interkinetic nuclear migration (GO:0022027)2.74970483
94transcytosis (GO:0045056)2.74493524
95* positive regulation of Rap GTPase activity (GO:0032854)2.72416107
96mitotic cell cycle arrest (GO:0071850)2.72156746
97cellular ketone body metabolic process (GO:0046950)2.72118897
98cellular biogenic amine catabolic process (GO:0042402)2.71685755
99amine catabolic process (GO:0009310)2.71685755
100positive regulation of antigen processing and presentation (GO:0002579)2.71262054
101indole-containing compound metabolic process (GO:0042430)2.71071566
102cell adhesion mediated by integrin (GO:0033627)2.70698804
103response to fluid shear stress (GO:0034405)2.70464668
104positive regulation of protein kinase C signaling (GO:0090037)2.69467545
105pyrimidine ribonucleoside catabolic process (GO:0046133)2.69079739
106coronary vasculature morphogenesis (GO:0060977)2.68661144
107regulation of B cell proliferation (GO:0030888)2.66465415
108platelet dense granule organization (GO:0060155)2.65951124
109cell migration involved in sprouting angiogenesis (GO:0002042)2.65507631
110positive regulation of heat generation (GO:0031652)2.64986386
111primary amino compound metabolic process (GO:1901160)2.64731147
112platelet-derived growth factor receptor signaling pathway (GO:0048008)2.64522450
113regulation of sarcomere organization (GO:0060297)2.63924445
114germ cell migration (GO:0008354)2.63740519
115epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.63127869
116positive regulation of focal adhesion assembly (GO:0051894)2.62956934
117positive regulation of cell junction assembly (GO:1901890)2.62956934
118vasculogenesis (GO:0001570)2.62453425
119glomerular visceral epithelial cell development (GO:0072015)2.61099413
120sulfation (GO:0051923)2.61063039
121T-helper 1 type immune response (GO:0042088)2.60252750
122positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.59140643
123sodium-independent organic anion transport (GO:0043252)2.57643513
124mature B cell differentiation (GO:0002335)2.57631294
125positive regulation of T-helper 1 type immune response (GO:0002827)2.56705874
126regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.55558457
127cortical actin cytoskeleton organization (GO:0030866)2.54579786
128chemical homeostasis within a tissue (GO:0048875)2.54429723
129phagocytosis, engulfment (GO:0006911)2.53849699
130positive regulation of lipid kinase activity (GO:0090218)2.52909681
131blood vessel endothelial cell migration (GO:0043534)2.51751739
132endothelial cell development (GO:0001885)2.51622429
133negative regulation of nitric-oxide synthase activity (GO:0051001)2.50796602
134negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50398517
135negative regulation of translation, ncRNA-mediated (GO:0040033)2.50398517
136regulation of translation, ncRNA-mediated (GO:0045974)2.50398517
137negative regulation of reactive oxygen species metabolic process (GO:2000378)2.49709783
138regulation of antigen processing and presentation (GO:0002577)2.49411288
139positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.48990215
140positive regulation of B cell differentiation (GO:0045579)2.48412447
141positive regulation of interleukin-12 production (GO:0032735)2.47931484
142synaptic transmission, cholinergic (GO:0007271)2.47159200
143positive regulation of adherens junction organization (GO:1903393)2.46739529
144detection of light stimulus involved in sensory perception (GO:0050962)2.46160068
145detection of light stimulus involved in visual perception (GO:0050908)2.46160068
146positive regulation of chemokine secretion (GO:0090197)2.45791307
147regulation of establishment or maintenance of cell polarity (GO:0032878)2.45630008
148B cell homeostasis (GO:0001782)2.44991925
149positive regulation of CREB transcription factor activity (GO:0032793)2.44892379
150positive regulation of prostaglandin secretion (GO:0032308)2.43995530
151N-acetylneuraminate metabolic process (GO:0006054)2.43915336
152interferon-gamma-mediated signaling pathway (GO:0060333)2.43498627
153ketone body metabolic process (GO:1902224)2.43200010
154regulation of platelet activation (GO:0010543)2.42989556
155cAMP catabolic process (GO:0006198)2.42841715
156regulation of establishment of cell polarity (GO:2000114)2.42481590
157positive regulation of gamma-delta T cell activation (GO:0046645)2.42026898
158neuronal action potential (GO:0019228)2.41630990
159regulation of interleukin-12 biosynthetic process (GO:0045075)2.40876883
160positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.39577128
161gamma-aminobutyric acid transport (GO:0015812)2.38207499
162regulation of interferon-gamma biosynthetic process (GO:0045072)2.35851305
163T cell migration (GO:0072678)2.34408098
164positive regulation of protein homooligomerization (GO:0032464)2.33840998
165regulation of T-helper 1 type immune response (GO:0002825)2.31039288
166positive regulation of mast cell activation (GO:0033005)2.30580879
167serotonin metabolic process (GO:0042428)2.30211985
168positive regulation of developmental pigmentation (GO:0048087)2.29881095
169regulation of heat generation (GO:0031650)2.28921113
170renal tubule morphogenesis (GO:0061333)2.28227332
171regulation of inositol phosphate biosynthetic process (GO:0010919)2.27462751
172interferon-gamma production (GO:0032609)2.27381255
173regulation of synapse structural plasticity (GO:0051823)2.26977064
174positive regulation of fatty acid transport (GO:2000193)2.26967478
175response to protozoan (GO:0001562)2.26867322
176purinergic receptor signaling pathway (GO:0035587)2.26602259
177positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.26420920
178negative regulation of interleukin-1 beta production (GO:0032691)2.26147901
179nephron tubule morphogenesis (GO:0072078)2.25860443
180nephron epithelium morphogenesis (GO:0072088)2.25860443
181negative regulation of systemic arterial blood pressure (GO:0003085)2.25158317
182negative regulation of interleukin-1 production (GO:0032692)2.22555032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.47599841
2EZH2_22144423_ChIP-Seq_EOC_Human3.82046408
3ZNF274_21170338_ChIP-Seq_K562_Hela3.45649378
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.33173194
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25541942
6GATA2_21666600_ChIP-Seq_HMVEC_Human3.24358219
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.12708068
8VDR_22108803_ChIP-Seq_LS180_Human2.99627293
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.95241446
10SMAD_19615063_ChIP-ChIP_OVARY_Human2.82098771
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69828534
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59144960
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.51384202
14* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.39178583
15RUNX_20019798_ChIP-Seq_JUKART_Human2.35294135
16SCL_19346495_ChIP-Seq_HPC-7_Human2.26527006
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.12860086
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.10476582
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.09660796
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.02216007
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.01138113
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99787593
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99665298
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.95194156
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92729893
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.91678709
27FLI1_27457419_Chip-Seq_LIVER_Mouse1.87566884
28GATA1_22025678_ChIP-Seq_K562_Human1.84803758
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82344185
30GBX2_23144817_ChIP-Seq_PC3_Human1.81137939
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73018037
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.72657886
33VDR_24787735_ChIP-Seq_THP-1_Human1.70405060
34SPI1_23127762_ChIP-Seq_K562_Human1.63561705
35IRF1_19129219_ChIP-ChIP_H3396_Human1.60106820
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59749097
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.58574735
38FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.58241354
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57950241
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55390684
41PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52608772
42SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51990469
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51270928
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49920935
45ER_23166858_ChIP-Seq_MCF-7_Human1.48527339
46ESR1_20079471_ChIP-ChIP_T-47D_Human1.48019585
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.47421376
48* CJUN_26792858_Chip-Seq_BT549_Human1.45654980
49TBX20_22080862_ChIP-Seq_HEART_Mouse1.45197012
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.45197012
51AR_21572438_ChIP-Seq_LNCaP_Human1.44737609
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43327276
53GATA3_21878914_ChIP-Seq_MCF-7_Human1.43063820
54BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.41006341
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39130938
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38714841
57RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38549639
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38022114
59* EP300_21415370_ChIP-Seq_HL-1_Mouse1.37547727
60TP53_16413492_ChIP-PET_HCT116_Human1.37415536
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36039767
62BCAT_22108803_ChIP-Seq_LS180_Human1.35604802
63GATA1_19941826_ChIP-Seq_K562_Human1.35303904
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34861806
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32978298
66ELK3_25401928_ChIP-Seq_HUVEC_Human1.32466172
67EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.32335298
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32090528
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28950353
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27281406
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26078346
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25714786
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25073130
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24937502
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24106008
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24106008
77GATA3_26560356_Chip-Seq_TH2_Human1.23255130
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21174024
79* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21171302
80CLOCK_20551151_ChIP-Seq_293T_Human1.20975684
81IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20326863
82FOXO3_23340844_ChIP-Seq_DLD1_Human1.19845996
83EWS_26573619_Chip-Seq_HEK293_Human1.19465338
84* STAT3_23295773_ChIP-Seq_U87_Human1.18752417
85NANOG_19829295_ChIP-Seq_ESCs_Human1.17225947
86SOX2_19829295_ChIP-Seq_ESCs_Human1.17225947
87* P300_19829295_ChIP-Seq_ESCs_Human1.15531577
88PPAR_26484153_Chip-Seq_NCI-H1993_Human1.15300997
89DROSHA_22980978_ChIP-Seq_HELA_Human1.14892570
90* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14052447
91REST_21632747_ChIP-Seq_MESCs_Mouse1.13249266
92AR_25329375_ChIP-Seq_VCAP_Human1.12401521
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12120652
94AHR_22903824_ChIP-Seq_MCF-7_Human1.11913246
95NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11763460
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11460015
97SMRT_27268052_Chip-Seq_Bcells_Human1.11225861
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11099626
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.11003389
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09868001
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08883552
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.08595259
103* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07612200
104* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07612200
105FOXA1_25329375_ChIP-Seq_VCAP_Human1.06682204
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06682204
107TAF2_19829295_ChIP-Seq_ESCs_Human1.06561323
108* TCF4_23295773_ChIP-Seq_U87_Human1.05201562
109MAF_26560356_Chip-Seq_TH1_Human1.04486028
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.04328553
111TP53_22573176_ChIP-Seq_HFKS_Human1.04210494
112* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03964966
113PU_27001747_Chip-Seq_BMDM_Mouse1.03915471
114SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03692083
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03622598
116SMAD4_21741376_ChIP-Seq_EPCs_Human1.03378117
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01536348
118FOXA2_19822575_ChIP-Seq_HepG2_Human1.01187910
119TAF15_26573619_Chip-Seq_HEK293_Human1.00844778
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00807847
121ESR2_21235772_ChIP-Seq_MCF-7_Human1.00064663
122FLI1_21867929_ChIP-Seq_TH2_Mouse0.99637742
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.99556301
124GATA2_19941826_ChIP-Seq_K562_Human0.99138592
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99109403
126ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98829937
127* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98423447
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97971829
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97459444
130VDR_24763502_ChIP-Seq_THP-1_Human0.97207251
131SOX2_20726797_ChIP-Seq_SW620_Human0.97159641
132PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97052393
133SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95334943
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95287660
135MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94819137
136SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94589887
137EZH2_27294783_Chip-Seq_ESCs_Mouse0.94162285
138NFE2_27457419_Chip-Seq_LIVER_Mouse0.93877050
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93828632
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93722280
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93643780
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92888835
143CBX2_27304074_Chip-Seq_ESCs_Mouse0.92877054
144EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92854318
145AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92545897
146* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92539906
147SMAD3_21741376_ChIP-Seq_HESCs_Human0.92313062
148* BRD4_25478319_ChIP-Seq_HGPS_Human0.91924194
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91186687
150ERA_21632823_ChIP-Seq_H3396_Human0.91087874
151CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91007606
152LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90928301
153* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.90785436
154EZH2_27294783_Chip-Seq_NPCs_Mouse0.90590432
155STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90265801
156TCF7_22412390_ChIP-Seq_EML_Mouse0.89959162
157* MYC_19829295_ChIP-Seq_ESCs_Human0.89804255
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89356168
159MYB_26560356_Chip-Seq_TH1_Human0.88978894
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.88941194
161IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88576421
162CBP_20019798_ChIP-Seq_JUKART_Human0.88576421
163* MYB_26560356_Chip-Seq_TH2_Human0.88373540
164CRX_20693478_ChIP-Seq_RETINA_Mouse0.88336211
165CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88213521
166CDX2_20551321_ChIP-Seq_CACO-2_Human0.88001940
167KDM2B_26808549_Chip-Seq_DND41_Human0.87816619
168* RUNX2_22187159_ChIP-Seq_PCA_Human0.87511780
169FUS_26573619_Chip-Seq_HEK293_Human0.87447007
170JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86919868
171* TP63_23658742_ChIP-Seq_EP156T_Human0.86419800
172ESR1_21235772_ChIP-Seq_MCF-7_Human0.85930666
173TP53_18474530_ChIP-ChIP_U2OS_Human0.84717186
174* TCF4_18268006_ChIP-ChIP_LS174T_Human0.83331620
175CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83164699

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system5.85022130
2MP0001879_abnormal_lymphatic_vessel5.78805803
3MP0005167_abnormal_blood-brain_barrier3.86499583
4MP0004272_abnormal_basement_membrane3.41794815
5MP0003828_pulmonary_edema3.35346379
6MP0006054_spinal_hemorrhage3.34022156
7MP0003646_muscle_fatigue3.05834509
8MP0003195_calcinosis2.76312521
9MP0005171_absent_coat_pigmentation2.61391902
10MP0003303_peritoneal_inflammation2.46712704
11MP0003724_increased_susceptibility_to2.44000344
12MP0001835_abnormal_antigen_presentation2.43721553
13MP0000767_abnormal_smooth_muscle2.40834141
14MP0005623_abnormal_meninges_morphology2.19553893
15MP0003191_abnormal_cellular_cholesterol2.15238479
16MP0002837_dystrophic_cardiac_calcinosis2.15041138
17MP0000569_abnormal_digit_pigmentation1.97099940
18MP0005409_darkened_coat_color1.94775585
19MP0003300_gastrointestinal_ulcer1.90453721
20MP0009785_altered_susceptibility_to1.88706387
21MP0001986_abnormal_taste_sensitivity1.88246896
22MP0004084_abnormal_cardiac_muscle1.86882099
23* MP0001800_abnormal_humoral_immune1.84836395
24MP0003136_yellow_coat_color1.84282974
25MP0003279_aneurysm1.78586193
26MP0000465_gastrointestinal_hemorrhage1.78432736
27MP0005387_immune_system_phenotype1.76075989
28MP0001790_abnormal_immune_system1.76075989
29MP0005671_abnormal_response_to1.74973628
30MP0000249_abnormal_blood_vessel1.74516094
31MP0004510_myositis1.73221960
32MP0009764_decreased_sensitivity_to1.71994633
33* MP0002452_abnormal_antigen_presenting1.70139328
34MP0004043_abnormal_pH_regulation1.69161958
35MP0004484_altered_response_of1.67124726
36MP0009046_muscle_twitch1.65512807
37MP0003690_abnormal_glial_cell1.64558214
38MP0005025_abnormal_response_to1.58722426
39MP0008875_abnormal_xenobiotic_pharmacok1.53286429
40MP0003091_abnormal_cell_migration1.53067702
41MP0009840_abnormal_foam_cell1.52481230
42MP0010234_abnormal_vibrissa_follicle1.51925712
43MP0006138_congestive_heart_failure1.51850343
44MP0005174_abnormal_tail_pigmentation1.49436862
45MP0004130_abnormal_muscle_cell1.46584996
46MP0003566_abnormal_cell_adhesion1.46132754
47MP0002419_abnormal_innate_immunity1.44613137
48MP0005165_increased_susceptibility_to1.42114013
49MP0004883_abnormal_blood_vessel1.40677072
50MP0003045_fibrosis1.40431131
51MP0005645_abnormal_hypothalamus_physiol1.39835131
52MP0004036_abnormal_muscle_relaxation1.39411668
53MP0005310_abnormal_salivary_gland1.38353854
54MP0005551_abnormal_eye_electrophysiolog1.38076290
55MP0001851_eye_inflammation1.37083018
56MP0000013_abnormal_adipose_tissue1.36740165
57MP0000920_abnormal_myelination1.35491440
58MP0001915_intracranial_hemorrhage1.33945810
59MP0006082_CNS_inflammation1.33285893
60MP0009745_abnormal_behavioral_response1.32279799
61MP0004142_abnormal_muscle_tone1.31095459
62MP0008872_abnormal_physiological_respon1.31043476
63MP0003252_abnormal_bile_duct1.30737771
64MP0005058_abnormal_lysosome_morphology1.30444078
65MP0010630_abnormal_cardiac_muscle1.28980784
66MP0005000_abnormal_immune_tolerance1.27946389
67* MP0002723_abnormal_immune_serum1.27518893
68MP0002925_abnormal_cardiovascular_devel1.26166387
69MP0002128_abnormal_blood_circulation1.25854877
70MP0002332_abnormal_exercise_endurance1.24302147
71MP0008877_abnormal_DNA_methylation1.22798789
72MP0005464_abnormal_platelet_physiology1.22600626
73MP0003950_abnormal_plasma_membrane1.21952827
74MP0002405_respiratory_system_inflammati1.20901688
75* MP0002420_abnormal_adaptive_immunity1.20607002
76* MP0001819_abnormal_immune_cell1.19580766
77MP0001968_abnormal_touch/_nociception1.17656829
78MP0001873_stomach_inflammation1.16506245
79MP0002102_abnormal_ear_morphology1.15464664
80MP0001614_abnormal_blood_vessel1.15422638
81MP0004885_abnormal_endolymph1.14554383
82MP0002735_abnormal_chemical_nociception1.12889378
83MP0000372_irregular_coat_pigmentation1.11019331
84MP0005595_abnormal_vascular_smooth1.10974837
85MP0000749_muscle_degeneration1.09910018
86MP0001501_abnormal_sleep_pattern1.09820240
87MP0001845_abnormal_inflammatory_respons1.09439455
88MP0004742_abnormal_vestibular_system1.09249390
89MP0005385_cardiovascular_system_phenoty1.08424663
90MP0001544_abnormal_cardiovascular_syste1.08424663
91MP0002064_seizures1.07508530
92MP0002653_abnormal_ependyma_morphology1.05947994
93MP0010678_abnormal_skin_adnexa1.05607928
94MP0000003_abnormal_adipose_tissue1.05277288
95MP0001853_heart_inflammation1.05176242
96MP0002972_abnormal_cardiac_muscle1.02727998
97MP0002148_abnormal_hypersensitivity_rea1.00747389
98MP0002138_abnormal_hepatobiliary_system1.00700889
99MP0005164_abnormal_response_to1.00567425
100MP0003172_abnormal_lysosome_physiology1.00386126
101MP0000733_abnormal_muscle_development1.00196358
102MP0004147_increased_porphyrin_level0.99607864
103MP0001663_abnormal_digestive_system0.98357977
104MP0005330_cardiomyopathy0.96352265
105MP0000343_altered_response_to0.96101678
106MP0002139_abnormal_hepatobiliary_system0.95331158
107MP0002876_abnormal_thyroid_physiology0.94160682
108MP0005084_abnormal_gallbladder_morpholo0.93861418
109MP0002928_abnormal_bile_duct0.93154736
110MP0001958_emphysema0.92897235
111MP0003567_abnormal_fetal_cardiomyocyte0.92743092
112MP0002272_abnormal_nervous_system0.90761949
113MP0002638_abnormal_pupillary_reflex0.90708824
114MP0000230_abnormal_systemic_arterial0.90512135
115MP0002933_joint_inflammation0.89767497
116MP0004145_abnormal_muscle_electrophysio0.89342703
117MP0001784_abnormal_fluid_regulation0.88982603
118MP0004215_abnormal_myocardial_fiber0.88800854
119MP0005670_abnormal_white_adipose0.86880818
120MP0005408_hypopigmentation0.86139036
121MP0008775_abnormal_heart_ventricle0.85711477
122MP0002067_abnormal_sensory_capabilities0.85629761
123MP0000015_abnormal_ear_pigmentation0.84209881
124MP0005085_abnormal_gallbladder_physiolo0.83305973
125MP0002396_abnormal_hematopoietic_system0.83043237
126* MP0000716_abnormal_immune_system0.82825309
127MP0002166_altered_tumor_susceptibility0.82397144
128* MP0002429_abnormal_blood_cell0.82246620
129MP0000689_abnormal_spleen_morphology0.82220533
130MP0009278_abnormal_bone_marrow0.82127577
131MP0002127_abnormal_cardiovascular_syste0.82034659
132MP0008469_abnormal_protein_level0.81904575
133MP0000266_abnormal_heart_morphology0.81718896
134MP0001919_abnormal_reproductive_system0.81670952
135MP0005620_abnormal_muscle_contractility0.81270703
136MP0002295_abnormal_pulmonary_circulatio0.80157809
137MP0003763_abnormal_thymus_physiology0.79934587
138MP0003436_decreased_susceptibility_to0.79893442
139MP0001533_abnormal_skeleton_physiology0.79644586
140MP0002398_abnormal_bone_marrow0.78638544
141MP0010386_abnormal_urinary_bladder0.78496444
142MP0003943_abnormal_hepatobiliary_system0.77197411
143MP0003633_abnormal_nervous_system0.77146052
144MP0002277_abnormal_respiratory_mucosa0.76765744
145MP0001970_abnormal_pain_threshold0.76692444
146MP0010155_abnormal_intestine_physiology0.75865264
147MP0002733_abnormal_thermal_nociception0.75243185
148MP0002693_abnormal_pancreas_physiology0.74737866
149MP0004087_abnormal_muscle_fiber0.73518676
150MP0000685_abnormal_immune_system0.73385678
151MP0005388_respiratory_system_phenotype0.73220580
152MP0002133_abnormal_respiratory_system0.73220580
153MP0004924_abnormal_behavior0.72808346
154MP0005386_behavior/neurological_phenoty0.72808346
155MP0005253_abnormal_eye_physiology0.72364661
156MP0005266_abnormal_metabolism0.72220982
157MP0005448_abnormal_energy_balance0.71551276

Predicted human phenotypes

RankGene SetZ-score
1Hematochezia (HP:0002573)5.47566664
2Colitis (HP:0002583)5.06720563
3Cerebral aneurysm (HP:0004944)4.61620994
4Spontaneous hematomas (HP:0007420)4.41924902
5Vascular tortuosity (HP:0004948)4.41532657
6Arterial tortuosity (HP:0005116)4.34697562
7Agammaglobulinemia (HP:0004432)4.15010659
8Aortic aneurysm (HP:0004942)3.96577802
9Congenital stationary night blindness (HP:0007642)3.94350985
10Systemic lupus erythematosus (HP:0002725)3.82343685
11Pancreatic cysts (HP:0001737)3.79940878
12Polycythemia (HP:0001901)3.77650248
13Gastrointestinal stroma tumor (HP:0100723)3.68560648
14Inflammation of the large intestine (HP:0002037)3.50881910
15Molar tooth sign on MRI (HP:0002419)3.49475815
16Abnormality of midbrain morphology (HP:0002418)3.49475815
17Glomerulonephritis (HP:0000099)3.40601467
18Tubular atrophy (HP:0000092)3.40378490
19Congenital, generalized hypertrichosis (HP:0004540)3.36441263
20Polydipsia (HP:0001959)3.23907873
21Abnormal drinking behavior (HP:0030082)3.23907873
22Axonal loss (HP:0003447)3.22705098
23Cellulitis (HP:0100658)3.19734844
24Gastrointestinal inflammation (HP:0004386)3.10844255
25Vacuolated lymphocytes (HP:0001922)3.06308850
26Inability to walk (HP:0002540)3.05199048
27Nonimmune hydrops fetalis (HP:0001790)3.03454196
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.02788521
29Abnormality of alanine metabolism (HP:0010916)3.02788521
30Hyperalaninemia (HP:0003348)3.02788521
31Segmental peripheral demyelination/remyelination (HP:0003481)2.98641882
32Hyperventilation (HP:0002883)2.97868036
33Attenuation of retinal blood vessels (HP:0007843)2.97324744
34Esophageal varix (HP:0002040)2.96646748
35Pancreatic fibrosis (HP:0100732)2.89045030
36Type II lissencephaly (HP:0007260)2.88280406
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.87185267
38Nephronophthisis (HP:0000090)2.83074164
39Abnormality of the renal cortex (HP:0011035)2.78960123
40Facial diplegia (HP:0001349)2.78914234
41Disproportionate tall stature (HP:0001519)2.78234992
42Myocardial infarction (HP:0001658)2.76694408
43Recurrent abscess formation (HP:0002722)2.76183316
44Decreased circulating renin level (HP:0003351)2.71801384
45True hermaphroditism (HP:0010459)2.70129208
46Aortic dissection (HP:0002647)2.66797140
47Conjunctival telangiectasia (HP:0000524)2.65918764
48Birth length less than 3rd percentile (HP:0003561)2.63489334
49Abnormal delayed hypersensitivity skin test (HP:0002963)2.61965347
50Abnormality of the renal medulla (HP:0100957)2.59959874
51Emphysema (HP:0002097)2.59274783
52Increased cerebral lipofuscin (HP:0011813)2.59194153
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.58860376
54Cerebral hemorrhage (HP:0001342)2.58175199
55Hemiparesis (HP:0001269)2.56029128
56Difficulty running (HP:0009046)2.55095602
57Clumsiness (HP:0002312)2.54217681
58Onion bulb formation (HP:0003383)2.53522807
59Absent hand (HP:0004050)2.50307770
60Hypoplasia of the iris (HP:0007676)2.48680008
61Protruding tongue (HP:0010808)2.47844034
62Abnormality of binocular vision (HP:0011514)2.45559735
63Diplopia (HP:0000651)2.45559735
64Muscle fiber splitting (HP:0003555)2.45410154
65Global brain atrophy (HP:0002283)2.44886948
66Abnormality of glycolipid metabolism (HP:0010969)2.41786730
67Abnormality of liposaccharide metabolism (HP:0010968)2.41786730
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.41786730
69Large for gestational age (HP:0001520)2.39551560
70Autoimmune thrombocytopenia (HP:0001973)2.38502345
71Stomatitis (HP:0010280)2.38490131
72Polyuria (HP:0000103)2.37318363
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.36133311
74Complement deficiency (HP:0004431)2.35755255
75Hyporeflexia of lower limbs (HP:0002600)2.34840486
76Thick nail (HP:0001805)2.33906814
77Recurrent pneumonia (HP:0006532)2.33800436
78Progressive inability to walk (HP:0002505)2.33046411
79Abnormal biliary tract physiology (HP:0012439)2.32995588
80Bile duct proliferation (HP:0001408)2.32995588
81Abolished electroretinogram (ERG) (HP:0000550)2.31628800
82Recurrent viral infections (HP:0004429)2.30225391
83Chronic hepatic failure (HP:0100626)2.29407435
84Genetic anticipation (HP:0003743)2.28757467
85Viral hepatitis (HP:0006562)2.28672733
86Recurrent bacterial skin infections (HP:0005406)2.28326623
87Chronic diarrhea (HP:0002028)2.27467207
88Urethral obstruction (HP:0000796)2.27212207
89Hemiplegia (HP:0002301)2.27190333
90Osteomyelitis (HP:0002754)2.26992928
91Mucosal telangiectasiae (HP:0100579)2.26024082
92Stomach cancer (HP:0012126)2.23755887
93Congenital hepatic fibrosis (HP:0002612)2.22623084
94Retrobulbar optic neuritis (HP:0100654)2.21829026
95Optic neuritis (HP:0100653)2.21829026
96Adactyly (HP:0009776)2.21382005
97Subacute progressive viral hepatitis (HP:0006572)2.21237915
98IgG deficiency (HP:0004315)2.21060340
99Bicuspid aortic valve (HP:0001647)2.20755039
100Striae distensae (HP:0001065)2.19657698
101Recurrent sinusitis (HP:0011108)2.18166062
102Fair hair (HP:0002286)2.17553265
103Dysostosis multiplex (HP:0000943)2.17220416
104Restrictive lung disease (HP:0002091)2.16901233
105Peripheral demyelination (HP:0011096)2.14705166
106Recurrent lower respiratory tract infections (HP:0002783)2.08637939
107Gaze-evoked nystagmus (HP:0000640)2.08473460
108Cystic liver disease (HP:0006706)2.08420668
109EMG: myopathic abnormalities (HP:0003458)2.07422268
110Portal hypertension (HP:0001409)2.05590048
111Nephritis (HP:0000123)2.05585690
112Verrucae (HP:0200043)2.05038805
113Papilloma (HP:0012740)2.05038805
114Abnormality of the right ventricle (HP:0001707)2.04289844
115Lymphangioma (HP:0100764)2.03246140
116Thyroiditis (HP:0100646)2.02983519
117Recurrent skin infections (HP:0001581)2.02479611
118Severe muscular hypotonia (HP:0006829)2.02270106
119Retinal atrophy (HP:0001105)2.02239155
120Progressive cerebellar ataxia (HP:0002073)2.00086265
121Chronic mucocutaneous candidiasis (HP:0002728)1.99838634
122Recurrent cutaneous fungal infections (HP:0011370)1.99838634
123Lymphopenia (HP:0001888)1.99087591
124Furrowed tongue (HP:0000221)1.97783360
125Exercise-induced muscle cramps (HP:0003710)1.96811753
126IgA deficiency (HP:0002720)1.95819484
127Hemoptysis (HP:0002105)1.94542384
128Broad-based gait (HP:0002136)1.93930047
129Aplasia cutis congenita (HP:0001057)1.93758286
130Decreased central vision (HP:0007663)1.91981229
131Exotropia (HP:0000577)1.91448443
132Skull defect (HP:0001362)1.91349486
133Porencephaly (HP:0002132)1.91048420
134Pendular nystagmus (HP:0012043)1.90701499
135Metabolic alkalosis (HP:0200114)1.90627992
136Aneurysm (HP:0002617)1.88846501
137Abnormal urine output (HP:0012590)1.88335791
138Pulmonary infiltrates (HP:0002113)1.88024952
139Cerebellar dysplasia (HP:0007033)1.87162059
140Congenital sensorineural hearing impairment (HP:0008527)1.86800780
141Recurrent fungal infections (HP:0002841)1.86612188
142Patellar aplasia (HP:0006443)1.86408902
143Concave nail (HP:0001598)1.85990670
144Mitral valve prolapse (HP:0001634)1.85364591
145Prostate neoplasm (HP:0100787)1.85298490
146Eosinophilia (HP:0001880)1.83113146
147Pulmonary artery stenosis (HP:0004415)1.82097175
148Sepsis (HP:0100806)1.81700134
149Abnormality of cells of the lymphoid lineage (HP:0012140)1.81687649
150Abnormality of the prostate (HP:0008775)1.80903332
151Generalized hypopigmentation of hair (HP:0011358)1.80202865
152Mitral stenosis (HP:0001718)1.79807460
153Abnormality of the hepatic vasculature (HP:0006707)1.79774244
154Abnormality of the pons (HP:0007361)1.79095795
155Decreased electroretinogram (ERG) amplitude (HP:0000654)1.78877140
156Pulmonary embolism (HP:0002204)1.78720672
157Mesangial abnormality (HP:0001966)1.78468188
158Recurrent bronchitis (HP:0002837)1.78082301
159Abnormal rod and cone electroretinograms (HP:0008323)1.77925275
160Vasculitis (HP:0002633)1.77898151
161B lymphocytopenia (HP:0010976)1.77416450
162Abnormality of B cell number (HP:0010975)1.77416450
163Abnormal pancreas size (HP:0012094)1.77160679
164Abnormality of T cell physiology (HP:0011840)1.77074337
165Encephalitis (HP:0002383)1.76975634
166Venous insufficiency (HP:0005293)1.76214617
167Spondylolisthesis (HP:0003302)1.76087137
168Short chin (HP:0000331)1.75849928
169Medial flaring of the eyebrow (HP:0010747)1.74298306
170Tubulointerstitial fibrosis (HP:0005576)1.74186557
171Febrile seizures (HP:0002373)1.74050099
172Hemorrhage of the eye (HP:0011885)1.73382625
173Intestinal atresia (HP:0011100)1.72924956
174Confusion (HP:0001289)1.72803028
175Dyskinesia (HP:0100660)1.72487507
176Pancreatic islet-cell hyperplasia (HP:0004510)1.72476159
177IgM deficiency (HP:0002850)1.71873260
178Eczematoid dermatitis (HP:0000976)1.71817970
179Premature skin wrinkling (HP:0100678)1.71489944
180Lissencephaly (HP:0001339)1.71379080
181Aplasia/Hypoplasia of the patella (HP:0006498)1.70665451
182Meningitis (HP:0001287)1.70306637
183Abnormality of complement system (HP:0005339)1.69779662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.91586680
2TGFBR26.05952430
3KDR5.40439113
4ACVR1B3.50012780
5FRK3.40573473
6ADRBK23.30064211
7TLK12.65139426
8MAP4K12.29380759
9MAP3K142.23616014
10DAPK21.93425146
11WNK41.89697458
12CSF1R1.84632773
13TAOK31.79586298
14MAPK121.78749668
15GRK71.78738109
16CAMK1G1.74090441
17CAMK1D1.65414317
18TGFBR11.63749127
19CAMKK21.62414305
20MAPK151.62103281
21ITK1.55972888
22DMPK1.55202006
23PDK21.54666685
24EPHB11.52038911
25TXK1.46120112
26GRK11.45499467
27TSSK61.44316768
28ZAK1.43554355
29STK101.42124860
30PINK11.41731510
31MAPK71.36643791
32PTK2B1.33642977
33TYK21.33435723
34TEC1.33037515
35FES1.27907859
36BLK1.26326542
37OXSR11.24984143
38MARK31.23686842
39PNCK1.21174684
40PKN11.19401295
41CSK1.17993323
42ERN11.17981416
43CLK11.17085932
44KIT1.16162843
45INSRR1.14220895
46TBK11.11324005
47PRKD11.10017687
48BMPR1B1.08164004
49IRAK41.05040948
50ADRBK11.03541630
51PTK61.02625086
52RIPK11.02342184
53PRKCH1.00992362
54IRAK11.00011022
55CHUK0.99073825
56HCK0.98242382
57JAK30.97667319
58MAP2K30.95973406
59MAPK130.95885184
60JAK10.92577823
61STK390.91344055
62FGFR20.91127161
63CSNK1A1L0.90117663
64WNK30.89147678
65SIK20.88774041
66MAP4K20.87380033
67LYN0.86678838
68IRAK30.85861737
69MAPKAPK30.85694969
70BRD40.85279658
71EPHB20.84833191
72NEK90.84331279
73MAP2K60.83831656
74RIPK40.82776546
75WNK10.82666735
76CAMKK10.82331598
77TRPM70.82207703
78TTN0.80921741
79TNIK0.75509170
80SYK0.74908101
81PAK40.74181915
82LRRK20.71614451
83RPS6KA50.70953175
84MKNK20.70567409
85FER0.68462491
86BMPR20.67111521
87PIK3CG0.66926048
88FGFR30.64593958
89PDPK10.64591877
90GSK3A0.64346736
91NUAK10.64237952
92IGF1R0.63556681
93LCK0.59724415
94PDK10.59520862
95PRKAA20.58339947
96RPS6KA60.58058047
97INSR0.57739075
98PKN20.56706931
99EGFR0.56586715
100TYRO30.54736836
101PIM10.54716415
102BTK0.54113832
103PRKCG0.52712088
104STK110.51681373
105CSNK1G10.49047491
106PAK20.48261781
107PDGFRB0.48140747
108MAP3K130.46610636
109OBSCN0.46336967
110* PRKCQ0.46261700
111NEK60.45600438
112MAP2K10.45328364
113ZAP700.44400280
114ABL10.44330101
115MAPKAPK50.42059205
116IKBKB0.41814710
117MAPKAPK20.41244288
118PIK3CA0.39360816
119PRKCE0.38667502
120CCNB10.38137034
121PAK30.37964649
122STK30.36904711
123VRK10.36283574
124CDC42BPA0.35874887
125MAPK110.35840452
126SRC0.35182420
127CSNK1G30.34305711
128CAMK40.34180337
129FYN0.33806611
130MARK20.33631235
131MAP3K40.33510290
132FGR0.33371434
133PRKG20.33307413
134SIK30.33234797
135MATK0.33174242
136MAPK40.33076746
137IKBKE0.31476015
138MET0.31396361
139NEK20.31307889
140SGK4940.31174391
141SGK2230.31174391
142PHKG20.30677800
143PHKG10.30677800
144CAMK2A0.30534223
145MAP3K90.29975637
146CAMK10.29272437
147SGK20.28542417

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.52098428
2Allograft rejection_Homo sapiens_hsa053303.21052026
3Autoimmune thyroid disease_Homo sapiens_hsa053202.89813044
4* B cell receptor signaling pathway_Homo sapiens_hsa046622.89067385
5Graft-versus-host disease_Homo sapiens_hsa053322.87690916
6Type I diabetes mellitus_Homo sapiens_hsa049402.30578555
7Osteoclast differentiation_Homo sapiens_hsa043802.25223966
8Leukocyte transendothelial migration_Homo sapiens_hsa046702.23504741
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.22869127
10Staphylococcus aureus infection_Homo sapiens_hsa051502.13688674
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.11573909
12Primary immunodeficiency_Homo sapiens_hsa053402.06962716
13Nitrogen metabolism_Homo sapiens_hsa009102.02932362
14Adherens junction_Homo sapiens_hsa045201.99047166
15Linoleic acid metabolism_Homo sapiens_hsa005911.94186065
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.86983088
17Hematopoietic cell lineage_Homo sapiens_hsa046401.82842943
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.68047182
19Phototransduction_Homo sapiens_hsa047441.61273544
20Platelet activation_Homo sapiens_hsa046111.58019063
21Other glycan degradation_Homo sapiens_hsa005111.56982172
22Leishmaniasis_Homo sapiens_hsa051401.55365253
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55145991
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54603618
25Focal adhesion_Homo sapiens_hsa045101.51795054
26Toxoplasmosis_Homo sapiens_hsa051451.45441811
27Lysosome_Homo sapiens_hsa041421.44598883
28Renal cell carcinoma_Homo sapiens_hsa052111.44170328
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.42036147
30Complement and coagulation cascades_Homo sapiens_hsa046101.41657033
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40962648
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36714942
33Dilated cardiomyopathy_Homo sapiens_hsa054141.36239296
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.34924617
35Tryptophan metabolism_Homo sapiens_hsa003801.33975054
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33068019
37* Rap1 signaling pathway_Homo sapiens_hsa040151.31726315
38Viral myocarditis_Homo sapiens_hsa054161.27752041
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27594466
40Pertussis_Homo sapiens_hsa051331.26968415
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25155182
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24815801
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23957457
44ECM-receptor interaction_Homo sapiens_hsa045121.21376711
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21104062
46Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17962134
47Chemokine signaling pathway_Homo sapiens_hsa040621.14909858
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13037889
49Small cell lung cancer_Homo sapiens_hsa052221.10753059
50Notch signaling pathway_Homo sapiens_hsa043301.09943196
51Dorso-ventral axis formation_Homo sapiens_hsa043201.09315870
52Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07268060
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05733097
54Endocytosis_Homo sapiens_hsa041441.03971023
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03116306
56African trypanosomiasis_Homo sapiens_hsa051431.01706189
57Malaria_Homo sapiens_hsa051441.00376615
58Renin secretion_Homo sapiens_hsa049240.99462121
59Pancreatic cancer_Homo sapiens_hsa052120.99424873
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97392075
61Axon guidance_Homo sapiens_hsa043600.97204791
62Salmonella infection_Homo sapiens_hsa051320.94221337
63Proteoglycans in cancer_Homo sapiens_hsa052050.94080635
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.93517970
65Selenocompound metabolism_Homo sapiens_hsa004500.91591560
66* Ras signaling pathway_Homo sapiens_hsa040140.91240557
67Morphine addiction_Homo sapiens_hsa050320.90584384
68Nicotine addiction_Homo sapiens_hsa050330.90502091
69Shigellosis_Homo sapiens_hsa051310.90411195
70Ovarian steroidogenesis_Homo sapiens_hsa049130.89512728
71Measles_Homo sapiens_hsa051620.88044029
72Chronic myeloid leukemia_Homo sapiens_hsa052200.87189635
73Butanoate metabolism_Homo sapiens_hsa006500.86974847
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.86183710
75RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85772956
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85242308
77Tuberculosis_Homo sapiens_hsa051520.84712733
78Amoebiasis_Homo sapiens_hsa051460.84115339
79cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83280309
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82274607
81Ether lipid metabolism_Homo sapiens_hsa005650.80829889
82Prostate cancer_Homo sapiens_hsa052150.79683420
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78970129
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78832676
85Caffeine metabolism_Homo sapiens_hsa002320.78543033
86Antigen processing and presentation_Homo sapiens_hsa046120.76898852
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.74819262
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74056992
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.73364487
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.72523132
91T cell receptor signaling pathway_Homo sapiens_hsa046600.71870597
92TNF signaling pathway_Homo sapiens_hsa046680.71731858
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71610936
94Calcium signaling pathway_Homo sapiens_hsa040200.71294900
95VEGF signaling pathway_Homo sapiens_hsa043700.70823893
96Influenza A_Homo sapiens_hsa051640.70323179
97Taste transduction_Homo sapiens_hsa047420.69862066
98ABC transporters_Homo sapiens_hsa020100.69476994
99Tight junction_Homo sapiens_hsa045300.68173083
100HIF-1 signaling pathway_Homo sapiens_hsa040660.67821837
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.67646710
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67645659
103Olfactory transduction_Homo sapiens_hsa047400.67495632
104Rheumatoid arthritis_Homo sapiens_hsa053230.66538071
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65519726
106Hepatitis B_Homo sapiens_hsa051610.64476026
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62474792
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61428731
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61364248
110Insulin resistance_Homo sapiens_hsa049310.61232462
111* Pathways in cancer_Homo sapiens_hsa052000.61223003
112Apoptosis_Homo sapiens_hsa042100.61197318
113Serotonergic synapse_Homo sapiens_hsa047260.60964133
114Arachidonic acid metabolism_Homo sapiens_hsa005900.60946470
115Estrogen signaling pathway_Homo sapiens_hsa049150.60849170
116Pancreatic secretion_Homo sapiens_hsa049720.59839416
117Hepatitis C_Homo sapiens_hsa051600.59588333
118Systemic lupus erythematosus_Homo sapiens_hsa053220.59341024
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58395653
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58349674
121TGF-beta signaling pathway_Homo sapiens_hsa043500.57845355
122* MAPK signaling pathway_Homo sapiens_hsa040100.57638505
123Insulin secretion_Homo sapiens_hsa049110.57108889
124MicroRNAs in cancer_Homo sapiens_hsa052060.56663890
125Fatty acid elongation_Homo sapiens_hsa000620.56537172
126Glutamatergic synapse_Homo sapiens_hsa047240.56031011
127Oxytocin signaling pathway_Homo sapiens_hsa049210.55498161
128cAMP signaling pathway_Homo sapiens_hsa040240.55239885
129Phagosome_Homo sapiens_hsa041450.55184540
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53494680
131Gastric acid secretion_Homo sapiens_hsa049710.53020964
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51144875
133Cardiac muscle contraction_Homo sapiens_hsa042600.49101115
134Glycerolipid metabolism_Homo sapiens_hsa005610.48338753
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47977595
136Histidine metabolism_Homo sapiens_hsa003400.47745183
137Herpes simplex infection_Homo sapiens_hsa051680.46736954
138Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45851842
139Mineral absorption_Homo sapiens_hsa049780.45454318
140Circadian entrainment_Homo sapiens_hsa047130.44116694
141Homologous recombination_Homo sapiens_hsa034400.43354164
142GABAergic synapse_Homo sapiens_hsa047270.41004551
143Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39315872
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38215639
145Cholinergic synapse_Homo sapiens_hsa047250.36368643
146Oxidative phosphorylation_Homo sapiens_hsa001900.35956739
147Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32767756
148Long-term depression_Homo sapiens_hsa047300.30617486
149Peroxisome_Homo sapiens_hsa041460.30382900
150Salivary secretion_Homo sapiens_hsa049700.30166351
151Legionellosis_Homo sapiens_hsa051340.30106394
152Collecting duct acid secretion_Homo sapiens_hsa049660.29660553
153Steroid hormone biosynthesis_Homo sapiens_hsa001400.26989537

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »