RASGRP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.96939357
2negative T cell selection (GO:0043383)6.53058599
3negative thymic T cell selection (GO:0045060)6.23753661
4response to interleukin-15 (GO:0070672)5.90394135
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.87332463
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.76151347
7locomotory exploration behavior (GO:0035641)5.75960346
8cellular response to interleukin-15 (GO:0071350)5.75048400
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.58564154
10regulation of B cell receptor signaling pathway (GO:0050855)5.56138224
11positive T cell selection (GO:0043368)5.47998486
12antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.45911181
13regulation of gamma-delta T cell differentiation (GO:0045586)5.45081893
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.44095183
15synaptic vesicle maturation (GO:0016188)5.40166933
16ionotropic glutamate receptor signaling pathway (GO:0035235)5.34096379
17vocalization behavior (GO:0071625)5.31433134
18regulation of gamma-delta T cell activation (GO:0046643)5.29919411
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25107313
20synaptic vesicle exocytosis (GO:0016079)5.22726788
21regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.20035104
22activated T cell proliferation (GO:0050798)5.06167113
23positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.04680451
24T cell migration (GO:0072678)5.03024766
25interferon-gamma production (GO:0032609)5.02969103
26negative regulation of T cell mediated immunity (GO:0002710)5.02362700
27regulation of glutamate receptor signaling pathway (GO:1900449)4.99803846
28positive thymic T cell selection (GO:0045059)4.99499409
29T cell selection (GO:0045058)4.97792579
30antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.97689895
31thymic T cell selection (GO:0045061)4.94230235
32glutamate secretion (GO:0014047)4.91543478
33synaptic vesicle docking involved in exocytosis (GO:0016081)4.91366982
34regulation of long-term neuronal synaptic plasticity (GO:0048169)4.89645842
35protein localization to synapse (GO:0035418)4.79679818
36regulation of synaptic vesicle exocytosis (GO:2000300)4.78821015
37antigen processing and presentation of endogenous antigen (GO:0019883)4.75203924
38regulation of neuronal synaptic plasticity (GO:0048168)4.69976441
39glutamate receptor signaling pathway (GO:0007215)4.69105674
40leukocyte aggregation (GO:0070486)4.68171694
41regulation of interleukin-2 biosynthetic process (GO:0045076)4.63975617
42exploration behavior (GO:0035640)4.63515360
43tolerance induction (GO:0002507)4.62438610
44neuronal action potential propagation (GO:0019227)4.60698138
45positive regulation of granulocyte differentiation (GO:0030854)4.56352964
46synaptic transmission, glutamatergic (GO:0035249)4.48104685
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.40527217
48regulation of synaptic vesicle transport (GO:1902803)4.38979440
49regulation of alpha-beta T cell proliferation (GO:0046640)4.38674449
50regulation of synapse structural plasticity (GO:0051823)4.36891425
51positive regulation of alpha-beta T cell proliferation (GO:0046641)4.34420659
52regulation of excitatory postsynaptic membrane potential (GO:0060079)4.33968079
53neuron-neuron synaptic transmission (GO:0007270)4.33874659
54G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.30149747
55long-term memory (GO:0007616)4.22908477
56regulation of isotype switching to IgG isotypes (GO:0048302)4.12456848
57negative regulation of lymphocyte mediated immunity (GO:0002707)4.12343600
58regulation of synaptic plasticity (GO:0048167)4.11317332
59regulation of dendritic spine morphogenesis (GO:0061001)4.10274691
60long-term synaptic potentiation (GO:0060291)4.09051669
61regulation of postsynaptic membrane potential (GO:0060078)4.03783425
62neuron cell-cell adhesion (GO:0007158)3.99187740
63neurotransmitter secretion (GO:0007269)3.93803433
64B cell receptor signaling pathway (GO:0050853)3.93233887
65positive regulation of membrane potential (GO:0045838)3.92135390
66neurotransmitter-gated ion channel clustering (GO:0072578)3.89544038
67membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85410731
68dendritic spine morphogenesis (GO:0060997)3.82622702
69regulation of T cell tolerance induction (GO:0002664)3.82210855
70positive regulation of neurotransmitter secretion (GO:0001956)3.79968257
71behavioral fear response (GO:0001662)3.79560353
72behavioral defense response (GO:0002209)3.79560353
73regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.79424364
74regulation of natural killer cell mediated immunity (GO:0002715)3.79424364
75response to histamine (GO:0034776)3.79247570
76cellular potassium ion homeostasis (GO:0030007)3.78074219
77gamma-aminobutyric acid signaling pathway (GO:0007214)3.73591265
78regulation of regulatory T cell differentiation (GO:0045589)3.69184489
79regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.67227944
80T cell receptor signaling pathway (GO:0050852)3.63360313
81alpha-beta T cell differentiation (GO:0046632)3.58062758
82antigen receptor-mediated signaling pathway (GO:0050851)3.57598129
83regulation of B cell differentiation (GO:0045577)3.57136477
84T cell homeostasis (GO:0043029)3.56689655
85negative regulation of cell killing (GO:0031342)3.54984825
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.54984825
87positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54925360
88chemosensory behavior (GO:0007635)3.53951117
89positive regulation of neurotransmitter transport (GO:0051590)3.52395046
90fear response (GO:0042596)3.50468527
91positive regulation of synapse maturation (GO:0090129)3.50111838
92negative regulation of leukocyte mediated immunity (GO:0002704)3.47765800
93regulation of T cell mediated cytotoxicity (GO:0001914)3.47466494
94regulation of synaptic transmission, glutamatergic (GO:0051966)3.46934082
95long term synaptic depression (GO:0060292)3.46154964
96synaptic vesicle endocytosis (GO:0048488)3.45151132
97regulation of dendritic spine development (GO:0060998)3.42361147
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.41586726
99behavioral response to cocaine (GO:0048148)3.39069620
100transmission of nerve impulse (GO:0019226)3.38246880
101regulation of leukocyte mediated cytotoxicity (GO:0001910)3.38002846
102positive regulation of interleukin-2 production (GO:0032743)3.36122237
103regulation of glutamate secretion (GO:0014048)3.35659138
104proline transport (GO:0015824)3.35627706
105dendritic spine organization (GO:0097061)3.35010806
106synaptic transmission, dopaminergic (GO:0001963)3.34370389
107positive regulation of natural killer cell mediated immunity (GO:0002717)3.34148537
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.33917140
109alpha-beta T cell activation (GO:0046631)3.33639826
110layer formation in cerebral cortex (GO:0021819)3.32961312
111sodium ion export (GO:0071436)3.32932693
112neuron recognition (GO:0008038)3.32715699
113neuromuscular process controlling balance (GO:0050885)3.32195266
114membrane depolarization (GO:0051899)3.32080949
115regulation of vesicle fusion (GO:0031338)3.30407915
116activation of protein kinase A activity (GO:0034199)3.30094865
117innervation (GO:0060384)3.30070858
118negative regulation of synaptic transmission, GABAergic (GO:0032229)3.29423559
119learning (GO:0007612)3.29344364
120positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.27010389
121positive regulation of B cell differentiation (GO:0045579)3.26320584
122positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26319695
123response to amphetamine (GO:0001975)3.25822897
124NIK/NF-kappaB signaling (GO:0038061)3.25301078
125regulation of neurotransmitter secretion (GO:0046928)3.24875174
126prepulse inhibition (GO:0060134)3.24657328
127regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.23981453
128regulation of tolerance induction (GO:0002643)3.22592194
129regulation of cell killing (GO:0031341)3.22346265
130regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.20786915
131cellular extravasation (GO:0045123)3.20183994
132positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19184790
133gamma-aminobutyric acid transport (GO:0015812)3.18708312
134positive regulation of synaptic transmission (GO:0050806)3.17987381
135positive regulation of tolerance induction (GO:0002645)3.17937296
136G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16683266
137phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.15248117
138neurotransmitter transport (GO:0006836)3.15223727
139regulation of female receptivity (GO:0045924)3.14543140
140Peyers patch development (GO:0048541)3.12921016
141mucosal-associated lymphoid tissue development (GO:0048537)3.12921016
142negative regulation of adaptive immune response (GO:0002820)3.12067438
143negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11447573
144positive regulation of cell killing (GO:0031343)3.10938782
145T cell differentiation (GO:0030217)3.10423280
146positive regulation of dendritic spine morphogenesis (GO:0061003)3.09049508
147negative regulation of amino acid transport (GO:0051956)3.08404589
148positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.08400564
149regulation of synaptic transmission (GO:0050804)3.08169617
150T cell costimulation (GO:0031295)3.07245481
151regulation of alpha-beta T cell activation (GO:0046634)3.06668490
152type I interferon signaling pathway (GO:0060337)3.05932339
153cellular response to type I interferon (GO:0071357)3.05932339
154striatum development (GO:0021756)3.04683609
155negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04503781
156membrane depolarization during action potential (GO:0086010)3.04328150
157response to type I interferon (GO:0034340)3.04306765
158positive regulation of dendritic spine development (GO:0060999)3.03561276
159lymphocyte costimulation (GO:0031294)3.03072432
160regulation of interleukin-2 production (GO:0032663)3.02851502
161regulation of neurotransmitter transport (GO:0051588)3.02626045
162regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.02224311
163positive regulation of natural killer cell differentiation (GO:0032825)3.01717804
164regulation of voltage-gated calcium channel activity (GO:1901385)3.01084091
165axonal fasciculation (GO:0007413)3.00638671
166lymphocyte migration (GO:0072676)2.99913665
167T-helper cell differentiation (GO:0042093)2.99801304
168CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.99801304
169regulation of granulocyte differentiation (GO:0030852)2.98917369
170regulation of neurotransmitter levels (GO:0001505)2.98701402
171positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.98477867
172cerebellar Purkinje cell differentiation (GO:0021702)2.98117069
173negative regulation of dendrite development (GO:2000171)2.97725598
174CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.97348334
175serotonin metabolic process (GO:0042428)2.97263284
176signal complex assembly (GO:0007172)2.96843326
177synaptic transmission (GO:0007268)2.96708801
178alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94789319
179alpha-beta T cell activation involved in immune response (GO:0002287)2.94789319
180T cell differentiation involved in immune response (GO:0002292)2.94789319
181modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94455885
182positive regulation by organism of defense response of other organism involved in symbiotic interact2.94455885
183modulation by symbiont of host immune response (GO:0052553)2.94455885
184positive regulation by symbiont of host defense response (GO:0052509)2.94455885
185modulation by symbiont of host defense response (GO:0052031)2.94455885
186modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94455885
187* mast cell activation (GO:0045576)2.93688586
188positive regulation of humoral immune response (GO:0002922)2.93054033
189natural killer cell differentiation (GO:0001779)2.93022250
190visual learning (GO:0008542)2.92897668
191positive regulation of alpha-beta T cell activation (GO:0046635)2.92324607
192auditory behavior (GO:0031223)2.92154678
193regulation of ARF protein signal transduction (GO:0032012)2.90480703
194lymphocyte homeostasis (GO:0002260)2.88023084
195detection of bacterium (GO:0016045)2.86896998
196negative regulation of interleukin-12 production (GO:0032695)2.85888190
197regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.85410940

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.80353060
2EZH2_22144423_ChIP-Seq_EOC_Human6.21751476
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.41042327
4RUNX_20019798_ChIP-Seq_JUKART_Human4.18291084
5GBX2_23144817_ChIP-Seq_PC3_Human3.61451839
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.58312815
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.50011989
8* MYB_26560356_Chip-Seq_TH2_Human3.22962658
9RARB_27405468_Chip-Seq_BRAIN_Mouse3.20459384
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14571301
11JARID2_20064375_ChIP-Seq_MESCs_Mouse3.13641305
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08148239
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.03883232
14BP1_19119308_ChIP-ChIP_Hs578T_Human3.00143713
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.98917597
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91320642
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.81287240
18REST_21632747_ChIP-Seq_MESCs_Mouse2.77653288
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72869701
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68877089
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68877089
22DROSHA_22980978_ChIP-Seq_HELA_Human2.58642182
23JARID2_20075857_ChIP-Seq_MESCs_Mouse2.57242623
24* MYB_26560356_Chip-Seq_TH1_Human2.55060793
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.53649021
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.52734787
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48260290
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44947832
29STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42069618
30* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40209125
31* GATA3_27048872_Chip-Seq_THYMUS_Human2.39575075
32MAF_26560356_Chip-Seq_TH1_Human2.33448384
33IRF8_27001747_Chip-Seq_BMDM_Mouse2.33277560
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23439814
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.22820599
36REST_18959480_ChIP-ChIP_MESCs_Mouse2.21308760
37EZH2_27304074_Chip-Seq_ESCs_Mouse2.21248167
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18651583
39SUZ12_27294783_Chip-Seq_ESCs_Mouse2.18062604
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.13775176
41EED_16625203_ChIP-ChIP_MESCs_Mouse2.05468693
42EZH2_27294783_Chip-Seq_ESCs_Mouse2.04845437
43SCL_19346495_ChIP-Seq_HPC-7_Human2.01044809
44MYC_22102868_ChIP-Seq_BL_Human1.97527540
45UTX_26944678_Chip-Seq_JUKART_Human1.97361357
46AR_21572438_ChIP-Seq_LNCaP_Human1.93774328
47* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.88315504
48MAF_26560356_Chip-Seq_TH2_Human1.87806250
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.83336457
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81172066
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79861011
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79493771
53TAF15_26573619_Chip-Seq_HEK293_Human1.77498421
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77402637
55* GATA3_26560356_Chip-Seq_TH2_Human1.76172135
56NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75435763
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.74535112
58SMAD4_21799915_ChIP-Seq_A2780_Human1.74146011
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.73235803
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70704675
61KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69126395
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68414350
63SPI1_23547873_ChIP-Seq_NB4_Human1.63313762
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58104780
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.53792462
66VDR_24787735_ChIP-Seq_THP-1_Human1.53498453
67P300_19829295_ChIP-Seq_ESCs_Human1.48433327
68SPI1_23127762_ChIP-Seq_K562_Human1.48139566
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.47091991
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.46928138
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43756387
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.43358896
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.43078530
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.38707642
75VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37701101
76* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36906083
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36750992
78NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34310953
79KDM2B_26808549_Chip-Seq_DND41_Human1.33316271
80TCF7_22412390_ChIP-Seq_EML_Mouse1.33159299
81VDR_24763502_ChIP-Seq_THP-1_Human1.32682963
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32619192
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31944792
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.31558337
85AR_25329375_ChIP-Seq_VCAP_Human1.31447951
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.27594431
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27047917
88SOX2_21211035_ChIP-Seq_LN229_Gbm1.26728102
89TP53_16413492_ChIP-PET_HCT116_Human1.26360714
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24968459
91PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23589306
92STAT3_23295773_ChIP-Seq_U87_Human1.23239165
93GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23169955
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.23167666
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22376109
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20972516
97* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20448002
98RING1B_27294783_Chip-Seq_ESCs_Mouse1.19011657
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18825218
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17889699
101* AR_19668381_ChIP-Seq_PC3_Human1.17618526
102* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17470826
103KDM2B_26808549_Chip-Seq_JURKAT_Human1.15787269
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15548022
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15490130
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15301725
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15112204
108PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14929486
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14390132
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14380923
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13929275
112* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12734961
113TCF4_23295773_ChIP-Seq_U87_Human1.10920033
114PU_27001747_Chip-Seq_BMDM_Mouse1.10161015
115RXR_22108803_ChIP-Seq_LS180_Human1.09902717
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08315521
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07692312
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07678850
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07625046
120ZNF274_21170338_ChIP-Seq_K562_Hela1.07530428
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07518458
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07176914
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07026487
124STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06101787
125EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05538440
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.05465064
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05101307
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04872040
129PIAS1_25552417_ChIP-Seq_VCAP_Human1.02646030
130* SMRT_27268052_Chip-Seq_Bcells_Human1.01916462
131PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01593442
132SMAD3_21741376_ChIP-Seq_HESCs_Human1.01559400
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01031541
134CIITA_25753668_ChIP-Seq_RAJI_Human1.00669088
135VDR_21846776_ChIP-Seq_THP-1_Human1.00549590
136AHR_22903824_ChIP-Seq_MCF-7_Human1.00001733
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.99695053
138POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99691622
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99403665
140YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98638783
141* KDM2B_26808549_Chip-Seq_K562_Human0.97702628
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.97600837
143FUS_26573619_Chip-Seq_HEK293_Human0.97303463
144UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96715731
145BCAT_22108803_ChIP-Seq_LS180_Human0.96304372
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95782577
147RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94873577
148TP53_18474530_ChIP-ChIP_U2OS_Human0.94251794
149GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93726181
150ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93563303
151* RUNX2_22187159_ChIP-Seq_PCA_Human0.93224508
152EGR1_19374776_ChIP-ChIP_THP-1_Human0.93145223
153ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91340434
154AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90168700
155SMAD3_21741376_ChIP-Seq_ESCs_Human0.89670891
156SUZ12_27294783_Chip-Seq_NPCs_Mouse0.89219191
157* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.88759787
158GATA3_26560356_Chip-Seq_TH1_Human0.88660780
159JUN_21703547_ChIP-Seq_K562_Human0.88646394
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87918151
161* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87888163
162SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87218864
163CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86136556
164CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.85636741
165* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84919866
166LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84761890
167SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84656624
168* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84054544
169SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.82276069
170NFE2_27457419_Chip-Seq_LIVER_Mouse0.81082098
171* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80937047
172CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79265526
173TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.78284964
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77025537
175TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75687392
176VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.75437012
177OCT4_21477851_ChIP-Seq_ESCs_Mouse0.75103433
178ESR1_20079471_ChIP-ChIP_T-47D_Human0.72660574
179E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72473634
180EZH2_27294783_Chip-Seq_NPCs_Mouse0.70889918
181* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.69327235
182FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69175280
183SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67447421
184GATA1_19941827_ChIP-Seq_MEL86_Mouse0.67238373
185* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67017885
186IRF1_19129219_ChIP-ChIP_H3396_Human0.65317417
187GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.64241781
188* GATA2_19941826_ChIP-Seq_K562_Human0.63777133
189STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.62501801

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.60172389
2MP0003880_abnormal_central_pattern5.50994961
3MP0003763_abnormal_thymus_physiology4.85488045
4MP0003635_abnormal_synaptic_transmissio4.48169676
5MP0005671_abnormal_response_to4.02778102
6MP0002822_catalepsy4.00905771
7MP0004270_analgesia3.84225253
8MP0009745_abnormal_behavioral_response3.80389679
9MP0002063_abnormal_learning/memory/cond3.72617088
10MP0001835_abnormal_antigen_presentation3.38325335
11* MP0001800_abnormal_humoral_immune3.35640384
12MP0002064_seizures3.32415051
13MP0005387_immune_system_phenotype3.31803874
14MP0001790_abnormal_immune_system3.31803874
15MP0001968_abnormal_touch/_nociception3.29782110
16MP0002572_abnormal_emotion/affect_behav3.02505680
17MP0000685_abnormal_immune_system2.96984745
18* MP0005000_abnormal_immune_tolerance2.91229952
19MP0003724_increased_susceptibility_to2.89186045
20MP0003300_gastrointestinal_ulcer2.88590567
21MP0003436_decreased_susceptibility_to2.82468293
22* MP0002723_abnormal_immune_serum2.75614193
23MP0001501_abnormal_sleep_pattern2.72255821
24MP0002736_abnormal_nociception_after2.69589619
25MP0009046_muscle_twitch2.68561950
26MP0002272_abnormal_nervous_system2.66253357
27* MP0002420_abnormal_adaptive_immunity2.62838424
28MP0004381_abnormal_hair_follicle2.62449344
29MP0003866_abnormal_defecation2.59039910
30* MP0001819_abnormal_immune_cell2.58532388
31MP0001486_abnormal_startle_reflex2.53341223
32MP0009785_altered_susceptibility_to2.51324619
33* MP0002452_abnormal_antigen_presenting2.49160596
34MP0005025_abnormal_response_to2.38073452
35MP0009333_abnormal_splenocyte_physiolog2.34622698
36* MP0002398_abnormal_bone_marrow2.33359072
37MP0002734_abnormal_mechanical_nocicepti2.32740739
38MP0002735_abnormal_chemical_nociception2.29337362
39* MP0000703_abnormal_thymus_morphology2.26364515
40MP0001873_stomach_inflammation2.19538795
41MP0006082_CNS_inflammation2.17009214
42* MP0000716_abnormal_immune_system2.15510215
43MP0001440_abnormal_grooming_behavior2.13881052
44MP0005423_abnormal_somatic_nervous2.12823742
45MP0002405_respiratory_system_inflammati2.12664588
46MP0002419_abnormal_innate_immunity2.01497462
47MP0010155_abnormal_intestine_physiology1.95887970
48MP0002148_abnormal_hypersensitivity_rea1.95784037
49MP0001970_abnormal_pain_threshold1.92661820
50* MP0000689_abnormal_spleen_morphology1.91645621
51MP0003329_amyloid_beta_deposits1.90536054
52MP0002733_abnormal_thermal_nociception1.89288505
53MP0008569_lethality_at_weaning1.85736314
54MP0002067_abnormal_sensory_capabilities1.84067072
55* MP0002722_abnormal_immune_system1.83041043
56MP0009780_abnormal_chondrocyte_physiolo1.77685750
57MP0002909_abnormal_adrenal_gland1.75628647
58MP0004811_abnormal_neuron_physiology1.72677668
59MP0005386_behavior/neurological_phenoty1.71909918
60MP0004924_abnormal_behavior1.71909918
61MP0002396_abnormal_hematopoietic_system1.65171050
62MP0002138_abnormal_hepatobiliary_system1.64531761
63* MP0001845_abnormal_inflammatory_respons1.63810414
64* MP0002429_abnormal_blood_cell1.62038153
65MP0001529_abnormal_vocalization1.61850578
66MP0003879_abnormal_hair_cell1.59985682
67MP0004947_skin_inflammation1.59856117
68MP0002557_abnormal_social/conspecific_i1.59394616
69MP0002166_altered_tumor_susceptibility1.59209857
70MP0002184_abnormal_innervation1.57317635
71MP0004510_myositis1.54530412
72MP0005646_abnormal_pituitary_gland1.53001491
73MP0004858_abnormal_nervous_system1.51915928
74MP0003787_abnormal_imprinting1.51430309
75MP0003633_abnormal_nervous_system1.47145641
76MP0005075_abnormal_melanosome_morpholog1.43642012
77MP0000778_abnormal_nervous_system1.38778268
78MP0001984_abnormal_olfaction1.36997172
79MP0001851_eye_inflammation1.33387422
80MP0002066_abnormal_motor_capabilities/c1.32351954
81MP0003075_altered_response_to1.31415478
82MP0000015_abnormal_ear_pigmentation1.29859569
83MP0001905_abnormal_dopamine_level1.29243845
84MP0008874_decreased_physiological_sensi1.27921962
85MP0008057_abnormal_DNA_replication1.27123479
86MP0002009_preneoplasia1.26934538
87MP0000955_abnormal_spinal_cord1.25649666
88MP0005409_darkened_coat_color1.25382890
89MP0002163_abnormal_gland_morphology1.24889261
90MP0002006_tumorigenesis1.21001071
91MP0002882_abnormal_neuron_morphology1.20110611
92MP0005464_abnormal_platelet_physiology1.18519243
93MP0002928_abnormal_bile_duct1.18224336
94MP0006276_abnormal_autonomic_nervous1.18162846
95MP0008872_abnormal_physiological_respon1.17987993
96MP0003631_nervous_system_phenotype1.14869618
97MP0001502_abnormal_circadian_rhythm1.11335969
98MP0001188_hyperpigmentation1.11147514
99MP0002933_joint_inflammation1.10901172
100MP0004885_abnormal_endolymph1.07924518
101MP0000465_gastrointestinal_hemorrhage1.04427905
102MP0005535_abnormal_body_temperature1.02750059
103MP0000604_amyloidosis1.02410318
104MP0005645_abnormal_hypothalamus_physiol1.02048367
105MP0008961_abnormal_basal_metabolism1.01001681
106MP0001533_abnormal_skeleton_physiology0.97695205
107MP0008469_abnormal_protein_level0.97206915
108MP0002277_abnormal_respiratory_mucosa0.95884596
109MP0003183_abnormal_peptide_metabolism0.94887367
110MP0001348_abnormal_lacrimal_gland0.94618898
111MP0010234_abnormal_vibrissa_follicle0.93531807
112MP0002069_abnormal_eating/drinking_beha0.92743501
113MP0002152_abnormal_brain_morphology0.91075635
114MP0008877_abnormal_DNA_methylation0.87158874
115MP0005167_abnormal_blood-brain_barrier0.85844800
116MP0008260_abnormal_autophagy0.85534189
117MP0002693_abnormal_pancreas_physiology0.84750290
118MP0004484_altered_response_of0.84451722
119MP0004808_abnormal_hematopoietic_stem0.82277550
120MP0001853_heart_inflammation0.82163771
121MP0009764_decreased_sensitivity_to0.81359521
122MP0001663_abnormal_digestive_system0.80920440
123MP0003252_abnormal_bile_duct0.80905500
124MP0004142_abnormal_muscle_tone0.78848178
125MP0000920_abnormal_myelination0.78508850
126MP0001177_atelectasis0.77084222
127MP0004883_abnormal_blood_vessel0.76036135
128MP0004085_abnormal_heartbeat0.76008917
129MP0002229_neurodegeneration0.75974257
130MP0000013_abnormal_adipose_tissue0.75951992
131MP0002837_dystrophic_cardiac_calcinosis0.75876104
132MP0005310_abnormal_salivary_gland0.75244366
133MP0010386_abnormal_urinary_bladder0.73360086
134MP0002998_abnormal_bone_remodeling0.73354415
135MP0000569_abnormal_digit_pigmentation0.71794314
136MP0005166_decreased_susceptibility_to0.70659543
137MP0004742_abnormal_vestibular_system0.68339566
138MP0000490_abnormal_crypts_of0.67549207
139MP0001986_abnormal_taste_sensitivity0.66057207
140MP0003690_abnormal_glial_cell0.65501510
141MP0005174_abnormal_tail_pigmentation0.64663894
142MP0004145_abnormal_muscle_electrophysio0.64132148
143MP0001765_abnormal_ion_homeostasis0.63698260
144MP0000751_myopathy0.63393117
145MP0005499_abnormal_olfactory_system0.63167197
146MP0005394_taste/olfaction_phenotype0.63167197
147MP0001963_abnormal_hearing_physiology0.63136230
148MP0001664_abnormal_digestion0.62315264
149MP0002019_abnormal_tumor_incidence0.61407268
150MP0003828_pulmonary_edema0.60982773
151MP0005379_endocrine/exocrine_gland_phen0.58070367
152MP0003634_abnormal_glial_cell0.58057565
153MP0003632_abnormal_nervous_system0.56533533
154MP0002132_abnormal_respiratory_system0.55269124
155MP0005451_abnormal_body_composition0.54479452
156MP0002876_abnormal_thyroid_physiology0.53889618
157MP0000858_altered_metastatic_potential0.53358625
158MP0005551_abnormal_eye_electrophysiolog0.52973960
159MP0003303_peritoneal_inflammation0.52814592
160MP0004215_abnormal_myocardial_fiber0.52431513
161MP0003045_fibrosis0.50984532
162MP0002090_abnormal_vision0.50371666
163MP0001485_abnormal_pinna_reflex0.50228529
164MP0003122_maternal_imprinting0.49085002
165MP0009765_abnormal_xenobiotic_induced0.48552545
166MP0009763_increased_sensitivity_to0.48348381
167MP0001919_abnormal_reproductive_system0.47404080
168MP0003191_abnormal_cellular_cholesterol0.46186490
169MP0003956_abnormal_body_size0.45828684
170MP0003172_abnormal_lysosome_physiology0.44277874
171MP0001943_abnormal_respiration0.43621586
172MP0002752_abnormal_somatic_nervous0.43519220
173MP0010769_abnormal_survival0.42766179
174MP0010768_mortality/aging0.40009250
175MP0004130_abnormal_muscle_cell0.39472103
176MP0000631_abnormal_neuroendocrine_gland0.38547860

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)9.24014687
2Myokymia (HP:0002411)7.86603758
3T lymphocytopenia (HP:0005403)6.54898658
4Focal seizures (HP:0007359)6.46702255
5Abnormality of T cell number (HP:0011839)6.09078835
6Visual hallucinations (HP:0002367)5.29574776
7Epileptic encephalopathy (HP:0200134)5.12213576
8Stomatitis (HP:0010280)5.09606509
9Atonic seizures (HP:0010819)4.98375199
10Febrile seizures (HP:0002373)4.87048047
11Absence seizures (HP:0002121)4.73645380
12Retrobulbar optic neuritis (HP:0100654)4.62005216
13Optic neuritis (HP:0100653)4.62005216
14Abnormality of T cells (HP:0002843)4.55814200
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.50717916
16Eczematoid dermatitis (HP:0000976)4.50431771
17Chronic mucocutaneous candidiasis (HP:0002728)4.49562196
18Recurrent cutaneous fungal infections (HP:0011370)4.49562196
19Myositis (HP:0100614)4.47062042
20Recurrent fungal infections (HP:0002841)4.46743988
21Dialeptic seizures (HP:0011146)4.34530560
22Progressive cerebellar ataxia (HP:0002073)4.22357006
23Generalized tonic-clonic seizures (HP:0002069)4.19089426
24Hyperventilation (HP:0002883)4.14025408
25Orchitis (HP:0100796)4.13058403
26Elevated erythrocyte sedimentation rate (HP:0003565)4.04510918
27Severe combined immunodeficiency (HP:0004430)4.02420027
28Panhypogammaglobulinemia (HP:0003139)3.93495733
29Impaired vibration sensation in the lower limbs (HP:0002166)3.91863096
30Broad-based gait (HP:0002136)3.90207131
31Action tremor (HP:0002345)3.89239438
32IgG deficiency (HP:0004315)3.78884096
33Poor eye contact (HP:0000817)3.78805237
34Autoimmune hemolytic anemia (HP:0001890)3.73505596
35Recurrent bacterial skin infections (HP:0005406)3.65690630
36Encephalitis (HP:0002383)3.61402341
37Gaze-evoked nystagmus (HP:0000640)3.60462911
38Recurrent viral infections (HP:0004429)3.58475920
39Recurrent bronchitis (HP:0002837)3.57089533
40Meningitis (HP:0001287)3.56634172
41Dysmetria (HP:0001310)3.51321046
42Amblyopia (HP:0000646)3.50297022
43Vasculitis (HP:0002633)3.45828362
44Chronic diarrhea (HP:0002028)3.45540401
45Supranuclear gaze palsy (HP:0000605)3.45101934
46Mediastinal lymphadenopathy (HP:0100721)3.44988223
47Increased IgM level (HP:0003496)3.43912299
48Impaired social interactions (HP:0000735)3.42765110
49Abnormal social behavior (HP:0012433)3.42765110
50Truncal ataxia (HP:0002078)3.42699369
51Depression (HP:0000716)3.39283163
52Lymphopenia (HP:0001888)3.37464119
53Recurrent abscess formation (HP:0002722)3.36841628
54Keratoconjunctivitis sicca (HP:0001097)3.31712619
55Pustule (HP:0200039)3.29899235
56Anxiety (HP:0000739)3.29008728
57Recurrent skin infections (HP:0001581)3.25186500
58Urinary bladder sphincter dysfunction (HP:0002839)3.24804736
59Impaired smooth pursuit (HP:0007772)3.23834367
60Dysdiadochokinesis (HP:0002075)3.21513030
61Pulmonary infiltrates (HP:0002113)3.15765667
62Keratoconjunctivitis (HP:0001096)3.14704141
63Abnormality of cells of the lymphoid lineage (HP:0012140)3.12636290
64Gastrointestinal infarctions (HP:0005244)3.11200066
65Abnormality of T cell physiology (HP:0011840)3.09963295
66Combined immunodeficiency (HP:0005387)3.09522586
67IgA deficiency (HP:0002720)3.05956711
68Joint swelling (HP:0001386)3.05582341
69Abnormality of eosinophils (HP:0001879)3.05125083
70IgM deficiency (HP:0002850)3.04376093
71Hemoptysis (HP:0002105)3.01757648
72Cerebral inclusion bodies (HP:0100314)2.97735312
73Postural instability (HP:0002172)2.95976625
74Papilledema (HP:0001085)2.95820253
75Urinary urgency (HP:0000012)2.90651599
76Stereotypic behavior (HP:0000733)2.90568779
77Ankle clonus (HP:0011448)2.85364453
78Dysmetric saccades (HP:0000641)2.83311431
79Abnormality of binocular vision (HP:0011514)2.83037187
80Diplopia (HP:0000651)2.83037187
81Annular pancreas (HP:0001734)2.82619842
82Leukocytosis (HP:0001974)2.81080460
83Excessive salivation (HP:0003781)2.79803893
84Drooling (HP:0002307)2.79803893
85Spontaneous hematomas (HP:0007420)2.79344220
86Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.78649298
87Thyroiditis (HP:0100646)2.76224815
88Scanning speech (HP:0002168)2.75806655
89Agammaglobulinemia (HP:0004432)2.73721721
90Slow saccadic eye movements (HP:0000514)2.71196216
91Eosinophilia (HP:0001880)2.71006929
92Abnormality of ocular smooth pursuit (HP:0000617)2.70490128
93Basal cell carcinoma (HP:0002671)2.70221153
94Abnormality of the lower motor neuron (HP:0002366)2.69060296
95Impaired vibratory sensation (HP:0002495)2.69050941
96Inflammation of the large intestine (HP:0002037)2.67138446
97Granulocytopenia (HP:0001913)2.63145703
98Abnormal eating behavior (HP:0100738)2.60235383
99Epileptiform EEG discharges (HP:0011182)2.59910285
100Absent speech (HP:0001344)2.59302563
101Abnormality of macrophages (HP:0004311)2.57968802
102Bradykinesia (HP:0002067)2.57481050
103Neurofibrillary tangles (HP:0002185)2.57447475
104Gastrointestinal inflammation (HP:0004386)2.53364943
105Torticollis (HP:0000473)2.52984403
106Focal dystonia (HP:0004373)2.52014358
107Abnormality of the fingertips (HP:0001211)2.49785871
108Progressive inability to walk (HP:0002505)2.48970960
109Termporal pattern (HP:0011008)2.48018570
110Insidious onset (HP:0003587)2.48018570
111Increased IgE level (HP:0003212)2.46434897
112Genetic anticipation (HP:0003743)2.44854883
113Chronic obstructive pulmonary disease (HP:0006510)2.43011173
114Obstructive lung disease (HP:0006536)2.43011173
115Hypoplasia of the thymus (HP:0000778)2.41411886
116Hemiparesis (HP:0001269)2.41025502
117Spastic gait (HP:0002064)2.39017932
118Abnormality of B cell number (HP:0010975)2.37335087
119Verrucae (HP:0200043)2.35668343
120Papilloma (HP:0012740)2.35668343
121Chest pain (HP:0100749)2.35103282
122Colitis (HP:0002583)2.34095771
123Pulmonary embolism (HP:0002204)2.32715033
124Resting tremor (HP:0002322)2.31985644
125Status epilepticus (HP:0002133)2.29240554
126Mutism (HP:0002300)2.27981258
127Intention tremor (HP:0002080)2.26179618
128Inability to walk (HP:0002540)2.24780496
129EEG with generalized epileptiform discharges (HP:0011198)2.24140089
130Gangrene (HP:0100758)2.23392681
131Hemiplegia (HP:0002301)2.21129707
132Ankyloglossia (HP:0010296)2.19622389
133B lymphocytopenia (HP:0010976)2.19027086
134Pointed chin (HP:0000307)2.18580467
135Lower limb amyotrophy (HP:0007210)2.18300420
136Deep palmar crease (HP:0006191)2.18246002
137Arterial thrombosis (HP:0004420)2.14935290
138Delusions (HP:0000746)2.14640417
139Megalencephaly (HP:0001355)2.14438417
140Lymphoma (HP:0002665)2.12208944
141Gastrointestinal stroma tumor (HP:0100723)2.11975754
142Incomplete penetrance (HP:0003829)2.11665057
143Generalized myoclonic seizures (HP:0002123)2.11443067
144Craniofacial dystonia (HP:0012179)2.07951574
145Autoimmune thrombocytopenia (HP:0001973)2.07917123
146Gait ataxia (HP:0002066)2.07157602
147Hypergammaglobulinemia (HP:0010702)2.07010314
148Lower limb asymmetry (HP:0100559)2.06703454
149Bronchitis (HP:0012387)2.06029828
150Abnormality of the pleura (HP:0002103)2.05138496
151Hypsarrhythmia (HP:0002521)2.05028682
152Blue irides (HP:0000635)2.02326880
153Abnormality of salivation (HP:0100755)2.02275333
154Recurrent sinusitis (HP:0011108)2.01885086
155Psychosis (HP:0000709)2.01037846
156Anorexia (HP:0002039)2.00975021
157Fetal akinesia sequence (HP:0001989)2.00494967
158Hydroureter (HP:0000072)1.99950174
159Ventricular fibrillation (HP:0001663)1.99782170
160Lower limb muscle weakness (HP:0007340)1.98484958
161Keratitis (HP:0000491)1.97920984
162Prolonged bleeding time (HP:0003010)1.97906508
163Chronic otitis media (HP:0000389)1.96960212
164Severe visual impairment (HP:0001141)1.95728793
165Abnormality of oral frenula (HP:0000190)1.94691910
166Inappropriate behavior (HP:0000719)1.93943850
167Protruding tongue (HP:0010808)1.92261130
168Gingivitis (HP:0000230)1.92039864
169Hypochromic anemia (HP:0001931)1.91813796
170Abnormal rod and cone electroretinograms (HP:0008323)1.91539195
171Rapidly progressive (HP:0003678)1.90799084
172Deeply set eye (HP:0000490)1.87422379
173Stomach cancer (HP:0012126)1.87091361
174Generalized hypopigmentation of hair (HP:0011358)1.83370299
175Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.82735257
176Recurrent gram-negative bacterial infections (HP:0005420)1.82510488
177Urticaria (HP:0001025)1.82222216
178Osteomyelitis (HP:0002754)1.82186382
179Viral hepatitis (HP:0006562)1.81172229
180Ocular albinism (HP:0001107)1.81091181
181Aqueductal stenosis (HP:0002410)1.81001648
182Abnormality of saccadic eye movements (HP:0000570)1.80364088
183Neuronal loss in central nervous system (HP:0002529)1.80063659
184Neoplasm of the tracheobronchial system (HP:0100552)1.79013480
185Widely spaced teeth (HP:0000687)1.78299961
186Rigidity (HP:0002063)1.77437316
187Abnormality of the endocardium (HP:0004306)1.76851113
188Fair hair (HP:0002286)1.75759859
189Thickened helices (HP:0000391)1.75451235
190Testicular atrophy (HP:0000029)1.74346825
191Acne (HP:0001061)1.74327445
192Amyotrophic lateral sclerosis (HP:0007354)1.73056586
193Abnormality of the corticospinal tract (HP:0002492)1.73016252
194Acute hepatic failure (HP:0006554)1.72130915
195Aplasia/Hypoplasia of the thymus (HP:0010515)1.71732010

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.22984999
2NTRK34.73131912
3MAP4K14.59552289
4RIPK44.39031983
5MAP3K93.47076073
6DAPK22.64571212
7MAP3K42.58960197
8KSR22.47571484
9TAOK32.41344593
10MINK12.38934204
11ITK2.34335211
12TYK22.32860052
13MAP2K72.18111248
14MAP3K132.17174673
15NLK2.15830881
16DAPK12.14496692
17IKBKE2.10448338
18MAP3K122.08580742
19CSK2.02777442
20BTK1.97863221
21PAK61.90276477
22JAK11.89646176
23PRKD31.85443200
24CAMKK11.81444598
25BMPR21.80648915
26KSR11.77340877
27JAK31.73933798
28ZAP701.72480059
29MAP2K41.66049375
30MAP3K141.65959935
31ARAF1.64787915
32FES1.63521249
33IRAK41.63311737
34SIK21.57957625
35BLK1.55674374
36LCK1.55294419
37NTRK11.54780222
38PLK21.49819654
39CDK51.49696831
40TEC1.49311702
41NTRK21.49086548
42MAP3K101.47535240
43PTK2B1.46113759
44FGFR31.42930222
45PASK1.35531023
46PRPF4B1.33976575
47GRK51.32280499
48RAF11.30743379
49MAP3K21.29414543
50CDK191.29105131
51CASK1.26606322
52STK381.22596940
53PNCK1.22064948
54MARK11.16898259
55LYN1.13245983
56PRKCG1.12189159
57TNIK1.12143280
58TYRO31.11839187
59JAK21.07990110
60FGFR41.06544900
61MARK31.06362714
62CAMK2B1.05923672
63EPHB11.05875570
64CAMK2A1.04445802
65CAMKK21.01595286
66TAOK10.95200784
67PDK10.95004836
68MAP2K30.94207245
69HIPK20.91439455
70IKBKB0.90950054
71CAMK10.89128403
72GRK60.88868307
73FGR0.88071111
74PRKCH0.87762437
75TNK20.85186534
76RET0.81368479
77MAP3K70.80922744
78STK110.78355852
79NME10.76678235
80SGK10.76190446
81MAP3K10.75373866
82CDK180.75149626
83PDPK10.73200131
84SGK20.72894101
85CDK150.71589899
86YES10.70769323
87FRK0.70684020
88CDK140.69522549
89SIK30.69495558
90SGK2230.68627531
91SGK4940.68627531
92TBK10.68443489
93MAP3K110.68285440
94SGK30.67874787
95UHMK10.67819676
96MAP2K60.66297179
97MAPK130.64511427
98MAPK110.63794093
99PIM10.62480956
100CDK11A0.62049293
101WNK10.61859589
102MAP3K30.60528374
103STK100.59031553
104SYK0.57990870
105CSF1R0.56243143
106FGFR20.55569417
107MELK0.53769376
108PINK10.53638312
109FYN0.53175560
110MARK20.52787488
111DYRK1A0.52438962
112PDGFRB0.50732972
113IRAK10.50169411
114DMPK0.49639490
115PIK3CG0.49326095
116CDK40.49293490
117PAK30.47131837
118TXK0.46505792
119BRD40.46410900
120EPHA30.45718355
121ALK0.45286217
122OXSR10.44342800
123CDK120.42305928
124RPS6KA30.41485469
125MAPK100.41330423
126MAP2K10.40786590
127DAPK30.39772067
128NUAK10.38794603
129CAMK40.38422624
130CAMK2D0.38189031
131PRKCZ0.37191666
132PIK3CA0.37065426
133CAMK2G0.33902390
134PRKD20.33669103
135PRKCE0.33528587
136NEK60.31552192
137HCK0.31267998
138* PRKCQ0.31208980
139PRKCB0.31101523
140CDK60.30203327
141EGFR0.29810351
142MOS0.27616055
143MAPK120.27263693
144PRKCA0.26725937
145MAPK70.26441370
146CAMK1G0.24376588
147FER0.24257873
148ROCK20.23297349
149CSNK1G20.22669506
150BRAF0.22538044
151CSNK1A10.21316263

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.93501628
2Nicotine addiction_Homo sapiens_hsa050333.59513269
3Long-term potentiation_Homo sapiens_hsa047203.17373268
4Olfactory transduction_Homo sapiens_hsa047402.78050755
5Amphetamine addiction_Homo sapiens_hsa050312.75319371
6Circadian entrainment_Homo sapiens_hsa047132.72304198
7Synaptic vesicle cycle_Homo sapiens_hsa047212.67804884
8Graft-versus-host disease_Homo sapiens_hsa053322.61946147
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.61921247
10Glutamatergic synapse_Homo sapiens_hsa047242.60514426
11Allograft rejection_Homo sapiens_hsa053302.60080401
12Morphine addiction_Homo sapiens_hsa050322.51665732
13Autoimmune thyroid disease_Homo sapiens_hsa053202.49187417
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.39890061
15GABAergic synapse_Homo sapiens_hsa047272.37286426
16Salivary secretion_Homo sapiens_hsa049702.35614188
17Dopaminergic synapse_Homo sapiens_hsa047282.19331955
18Measles_Homo sapiens_hsa051622.14747645
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10833061
20NF-kappa B signaling pathway_Homo sapiens_hsa040642.03108430
21Gastric acid secretion_Homo sapiens_hsa049711.96206488
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.92750704
23Renin secretion_Homo sapiens_hsa049241.91008250
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90982965
25Cholinergic synapse_Homo sapiens_hsa047251.87295663
26Insulin secretion_Homo sapiens_hsa049111.85416818
27Oxytocin signaling pathway_Homo sapiens_hsa049211.77347512
28Calcium signaling pathway_Homo sapiens_hsa040201.75807864
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.71697366
30Long-term depression_Homo sapiens_hsa047301.69918719
31Taste transduction_Homo sapiens_hsa047421.69024661
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.63293103
33Leishmaniasis_Homo sapiens_hsa051401.58837085
34Hematopoietic cell lineage_Homo sapiens_hsa046401.58604667
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57788365
36Cocaine addiction_Homo sapiens_hsa050301.56867301
37Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56687011
38Serotonergic synapse_Homo sapiens_hsa047261.56419101
39Acute myeloid leukemia_Homo sapiens_hsa052211.53464222
40Antigen processing and presentation_Homo sapiens_hsa046121.52967075
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52444186
42GnRH signaling pathway_Homo sapiens_hsa049121.48827850
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.46162597
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40889249
45Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39883746
46TNF signaling pathway_Homo sapiens_hsa046681.38923259
47cAMP signaling pathway_Homo sapiens_hsa040241.32751785
48Hepatitis B_Homo sapiens_hsa051611.32695717
49Viral myocarditis_Homo sapiens_hsa054161.30179319
50Collecting duct acid secretion_Homo sapiens_hsa049661.28952430
51Herpes simplex infection_Homo sapiens_hsa051681.27014817
52Gap junction_Homo sapiens_hsa045401.24727128
53Glioma_Homo sapiens_hsa052141.24625859
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.19922780
55Influenza A_Homo sapiens_hsa051641.13269609
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12536238
57Estrogen signaling pathway_Homo sapiens_hsa049151.10039730
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08234711
59Type II diabetes mellitus_Homo sapiens_hsa049301.07421245
60Toxoplasmosis_Homo sapiens_hsa051451.06627495
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04372347
62Melanogenesis_Homo sapiens_hsa049161.02297320
63Malaria_Homo sapiens_hsa051441.01754843
64VEGF signaling pathway_Homo sapiens_hsa043701.00492541
65ErbB signaling pathway_Homo sapiens_hsa040121.00361463
66Asthma_Homo sapiens_hsa053100.99539353
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.98695568
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.98142172
69Colorectal cancer_Homo sapiens_hsa052100.97372178
70African trypanosomiasis_Homo sapiens_hsa051430.96435497
71Hepatitis C_Homo sapiens_hsa051600.95787247
72Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95376831
73Prolactin signaling pathway_Homo sapiens_hsa049170.93457384
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.93420426
75Pancreatic secretion_Homo sapiens_hsa049720.93390290
76Staphylococcus aureus infection_Homo sapiens_hsa051500.91218271
77Pancreatic cancer_Homo sapiens_hsa052120.90321732
78FoxO signaling pathway_Homo sapiens_hsa040680.89737567
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89382454
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87643713
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87301240
82Dorso-ventral axis formation_Homo sapiens_hsa043200.86711231
83Axon guidance_Homo sapiens_hsa043600.85670841
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85115833
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.83712053
86Choline metabolism in cancer_Homo sapiens_hsa052310.83269659
87Oocyte meiosis_Homo sapiens_hsa041140.82835384
88Epstein-Barr virus infection_Homo sapiens_hsa051690.80811378
89Apoptosis_Homo sapiens_hsa042100.80161207
90Chronic myeloid leukemia_Homo sapiens_hsa052200.79101595
91Type I diabetes mellitus_Homo sapiens_hsa049400.76625254
92Thyroid hormone synthesis_Homo sapiens_hsa049180.76304405
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73894130
94HTLV-I infection_Homo sapiens_hsa051660.73334802
95Viral carcinogenesis_Homo sapiens_hsa052030.70984539
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.70390770
97* MAPK signaling pathway_Homo sapiens_hsa040100.70359847
98Cardiac muscle contraction_Homo sapiens_hsa042600.68487302
99Vibrio cholerae infection_Homo sapiens_hsa051100.68201014
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68078268
101* T cell receptor signaling pathway_Homo sapiens_hsa046600.67834259
102Non-small cell lung cancer_Homo sapiens_hsa052230.67721285
103Rap1 signaling pathway_Homo sapiens_hsa040150.66798285
104Phototransduction_Homo sapiens_hsa047440.65538405
105Nitrogen metabolism_Homo sapiens_hsa009100.64359911
106Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63488074
107Prostate cancer_Homo sapiens_hsa052150.63434569
108Chemokine signaling pathway_Homo sapiens_hsa040620.62609352
109Legionellosis_Homo sapiens_hsa051340.61675475
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61062061
111Sphingolipid signaling pathway_Homo sapiens_hsa040710.60841911
112Glucagon signaling pathway_Homo sapiens_hsa049220.60181005
113mTOR signaling pathway_Homo sapiens_hsa041500.59245230
114Regulation of autophagy_Homo sapiens_hsa041400.57730052
115Inositol phosphate metabolism_Homo sapiens_hsa005620.57705630
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57176828
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53610192
118Dilated cardiomyopathy_Homo sapiens_hsa054140.53461638
119B cell receptor signaling pathway_Homo sapiens_hsa046620.52725082
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52642243
121* Ras signaling pathway_Homo sapiens_hsa040140.52469832
122Thyroid cancer_Homo sapiens_hsa052160.50836826
123HIF-1 signaling pathway_Homo sapiens_hsa040660.49610085
124Shigellosis_Homo sapiens_hsa051310.48576896
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46368399
126Endocytosis_Homo sapiens_hsa041440.45887946
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42708476
128Prion diseases_Homo sapiens_hsa050200.40902121
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38859134
130Alcoholism_Homo sapiens_hsa050340.38759379
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37094552
132Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35999268
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35236000
134Insulin resistance_Homo sapiens_hsa049310.35101540
135Wnt signaling pathway_Homo sapiens_hsa043100.35054620
136Circadian rhythm_Homo sapiens_hsa047100.34864753
137Tuberculosis_Homo sapiens_hsa051520.34628226
138Osteoclast differentiation_Homo sapiens_hsa043800.34354275
139Salmonella infection_Homo sapiens_hsa051320.33176996
140Endometrial cancer_Homo sapiens_hsa052130.31449322
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31362538
142Alzheimers disease_Homo sapiens_hsa050100.31001261
143Renal cell carcinoma_Homo sapiens_hsa052110.30919667
144* Platelet activation_Homo sapiens_hsa046110.30543821
145Rheumatoid arthritis_Homo sapiens_hsa053230.29670280
146Bile secretion_Homo sapiens_hsa049760.27809539
147Insulin signaling pathway_Homo sapiens_hsa049100.27580286
148Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27436919
149Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27089832

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