RARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Arginyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)5.00760694
2establishment of integrated proviral latency (GO:0075713)4.70161301
3nucleobase biosynthetic process (GO:0046112)4.48595819
4ribosome assembly (GO:0042255)4.47679251
5nuclear pore organization (GO:0006999)4.40950524
6mitotic metaphase plate congression (GO:0007080)4.39734355
7IMP biosynthetic process (GO:0006188)4.38557004
8purine nucleobase biosynthetic process (GO:0009113)4.31894885
9maturation of SSU-rRNA (GO:0030490)4.28990346
10folic acid-containing compound biosynthetic process (GO:0009396)4.28247325
11DNA unwinding involved in DNA replication (GO:0006268)4.27388046
12mitotic nuclear envelope disassembly (GO:0007077)4.19188510
13nuclear pore complex assembly (GO:0051292)4.13650333
14ribosome biogenesis (GO:0042254)4.11297769
15protein localization to kinetochore (GO:0034501)4.10099582
16DNA replication initiation (GO:0006270)4.01407106
17DNA strand elongation involved in DNA replication (GO:0006271)4.00318431
18membrane disassembly (GO:0030397)3.90586200
19nuclear envelope disassembly (GO:0051081)3.90586200
20establishment of viral latency (GO:0019043)3.86832171
21IMP metabolic process (GO:0046040)3.84648792
22DNA strand elongation (GO:0022616)3.80673428
23DNA replication checkpoint (GO:0000076)3.72004517
24ribonucleoprotein complex biogenesis (GO:0022613)3.69650381
25metaphase plate congression (GO:0051310)3.67109251
26ribosomal small subunit assembly (GO:0000028)3.62024758
27double-strand break repair via nonhomologous end joining (GO:0006303)3.61971206
28non-recombinational repair (GO:0000726)3.61971206
29ribosomal large subunit biogenesis (GO:0042273)3.59551701
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58201119
31DNA replication-dependent nucleosome assembly (GO:0006335)3.56299703
32DNA replication-dependent nucleosome organization (GO:0034723)3.56299703
33cullin deneddylation (GO:0010388)3.56018605
34telomere maintenance via semi-conservative replication (GO:0032201)3.51934456
35regulation of spindle organization (GO:0090224)3.49131484
36regulation of centriole replication (GO:0046599)3.41989241
37protein localization to chromosome, centromeric region (GO:0071459)3.33209082
38rRNA processing (GO:0006364)3.30481869
39establishment of chromosome localization (GO:0051303)3.30105485
40telomere maintenance via recombination (GO:0000722)3.28644806
41CENP-A containing nucleosome assembly (GO:0034080)3.28213247
42chromatin remodeling at centromere (GO:0031055)3.27993899
43translational initiation (GO:0006413)3.25971897
44protein deneddylation (GO:0000338)3.25389803
45DNA ligation (GO:0006266)3.23455107
46pore complex assembly (GO:0046931)3.22192188
47spliceosomal snRNP assembly (GO:0000387)3.20069637
48rRNA metabolic process (GO:0016072)3.19983456
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19858868
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19455314
51regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19346787
52mitotic recombination (GO:0006312)3.18586441
53positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15117978
54kinetochore organization (GO:0051383)3.14543031
55mitotic sister chromatid cohesion (GO:0007064)3.14110714
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14081892
57mitotic sister chromatid segregation (GO:0000070)3.09544213
58DNA replication-independent nucleosome assembly (GO:0006336)3.07595254
59DNA replication-independent nucleosome organization (GO:0034724)3.07595254
60translational termination (GO:0006415)3.07160209
61mitotic chromosome condensation (GO:0007076)3.03049667
62folic acid metabolic process (GO:0046655)3.02677036
63regulation of cellular amino acid metabolic process (GO:0006521)3.02443124
64viral transcription (GO:0019083)3.00616867
65telomere maintenance via telomere lengthening (GO:0010833)3.00615427
66nuclear envelope organization (GO:0006998)3.00116865
67G1/S transition of mitotic cell cycle (GO:0000082)2.99863431
68cell cycle G1/S phase transition (GO:0044843)2.99863431
69establishment of protein localization to mitochondrial membrane (GO:0090151)2.99369558
70regulation of mitotic spindle organization (GO:0060236)2.98601361
71heterochromatin organization (GO:0070828)2.98186916
72regulation of mitotic sister chromatid separation (GO:0010965)2.98106007
73regulation of mitotic sister chromatid segregation (GO:0033047)2.98106007
74regulation of sister chromatid segregation (GO:0033045)2.98106007
75ribosomal small subunit biogenesis (GO:0042274)2.97732993
76proteasome assembly (GO:0043248)2.97296896
77regulation of translational fidelity (GO:0006450)2.96686036
78regulation of translational termination (GO:0006449)2.96642223
79nucleobase-containing small molecule interconversion (GO:0015949)2.96333051
80DNA geometric change (GO:0032392)2.96229045
81regulation of ubiquitin-protein transferase activity (GO:0051438)2.95793910
82positive regulation of ligase activity (GO:0051351)2.95786141
83DNA duplex unwinding (GO:0032508)2.95455382
84spindle checkpoint (GO:0031577)2.95417102
85regulation of mitochondrial translation (GO:0070129)2.94759162
86histone-serine phosphorylation (GO:0035404)2.94625982
87translational elongation (GO:0006414)2.93463751
88mitochondrial RNA metabolic process (GO:0000959)2.92945120
89sister chromatid segregation (GO:0000819)2.92282164
90regulation of centrosome cycle (GO:0046605)2.92225325
91negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.91982659
92negative regulation of ligase activity (GO:0051352)2.91982659
93viral mRNA export from host cell nucleus (GO:0046784)2.91743732
94attachment of spindle microtubules to kinetochore (GO:0008608)2.91715731
95negative regulation of chromosome segregation (GO:0051985)2.90519804
96pseudouridine synthesis (GO:0001522)2.90340609
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.90312358
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.90312358
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.90312358
100DNA double-strand break processing (GO:0000729)2.90144422
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89769818
102negative regulation of sister chromatid segregation (GO:0033046)2.89769818
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.89769818
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89769818
105mitotic spindle assembly checkpoint (GO:0007094)2.89173319
106intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.88651152
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.88651152
108spindle assembly checkpoint (GO:0071173)2.88514057
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88420188
110rRNA modification (GO:0000154)2.87738890
111* tRNA aminoacylation for protein translation (GO:0006418)2.87076090
112pteridine-containing compound biosynthetic process (GO:0042559)2.86238422
113regulation of mitotic metaphase/anaphase transition (GO:0030071)2.86133752
114mitotic spindle checkpoint (GO:0071174)2.85953349
115DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85782357
116regulation of ligase activity (GO:0051340)2.85628400
117signal transduction involved in DNA damage checkpoint (GO:0072422)2.85381051
118signal transduction involved in DNA integrity checkpoint (GO:0072401)2.85381051
119positive regulation of chromosome segregation (GO:0051984)2.84801032
120regulation of translation in response to stress (GO:0043555)2.83331711
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83308536
122nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.81390964
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80323619
124regulation of chromosome segregation (GO:0051983)2.79329093
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.78917055
126protein K6-linked ubiquitination (GO:0085020)2.78029633
127kinetochore assembly (GO:0051382)2.77902643
128* tRNA aminoacylation (GO:0043039)2.77833027
129* amino acid activation (GO:0043038)2.77833027
130histone exchange (GO:0043486)2.77349040
131transcription-coupled nucleotide-excision repair (GO:0006283)2.76825524
132maturation of 5.8S rRNA (GO:0000460)2.76357991

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.00488382
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.43428300
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81506497
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.67719104
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.37933143
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07768216
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06398044
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.91149423
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.89021867
10* GABP_17652178_ChIP-ChIP_JURKAT_Human2.88379541
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87087931
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77156506
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.76240453
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.67470229
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66386757
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.54162940
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.47207069
18AR_21909140_ChIP-Seq_LNCAP_Human2.31071739
19XRN2_22483619_ChIP-Seq_HELA_Human2.27053248
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18931792
21VDR_23849224_ChIP-Seq_CD4+_Human2.13878195
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09374484
23DCP1A_22483619_ChIP-Seq_HELA_Human2.05356316
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04817423
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02996874
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.94975378
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93988146
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92446269
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91318221
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89993814
31* GABP_19822575_ChIP-Seq_HepG2_Human1.86051690
32POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84852741
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84344063
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.84048864
35ELK1_19687146_ChIP-ChIP_HELA_Human1.83929905
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82067758
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.80346108
38TTF2_22483619_ChIP-Seq_HELA_Human1.76438937
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75719687
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.68759268
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.63246509
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61663313
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60874918
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.59778353
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57393130
46* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55878191
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54121175
48KDM5A_27292631_Chip-Seq_BREAST_Human1.50109111
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.49658250
50MYC_22102868_ChIP-Seq_BL_Human1.47613049
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47033582
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43030199
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42117754
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41175818
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41013597
56TFEB_21752829_ChIP-Seq_HELA_Human1.39691849
57CIITA_25753668_ChIP-Seq_RAJI_Human1.36267445
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34727425
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32481129
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.31032766
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28399150
62PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25665037
63NANOG_16153702_ChIP-ChIP_HESCs_Human1.24835322
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.24607095
65* SOX17_20123909_ChIP-Seq_XEN_Mouse1.24604334
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22931558
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21574823
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14149593
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.14056617
70EWS_26573619_Chip-Seq_HEK293_Human1.13922552
71ERG_20887958_ChIP-Seq_HPC-7_Mouse1.12967434
72SALL1_21062744_ChIP-ChIP_HESCs_Human1.09981550
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.09773980
74FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08904893
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08842271
76SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.08730023
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.08266953
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07847512
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06763672
80* FUS_26573619_Chip-Seq_HEK293_Human1.03978206
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03759046
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03523466
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03436996
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02192233
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00022287
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98490025
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.97705651
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97649676
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97212802
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97001532
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96720376
92* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96020875
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.95797428
94BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95533515
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95143522
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93284110
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91709614
98NOTCH1_21737748_ChIP-Seq_TLL_Human0.91409565
99* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91356488
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91305495
101NANOG_21062744_ChIP-ChIP_HESCs_Human0.90852789
102SOX2_16153702_ChIP-ChIP_HESCs_Human0.89677085
103HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88544695
104HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85115794
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83609000
106SPI1_23547873_ChIP-Seq_NB4_Human0.83179845
107ATF3_27146783_Chip-Seq_COLON_Human0.82816791
108SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82751753
109GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82726660
110MYC_18940864_ChIP-ChIP_HL60_Human0.82532490
111POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81748326
112RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81707299
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80688388
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80387940
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.80174335
116ELF5_23300383_ChIP-Seq_T47D_Human0.80145774
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79593189
118TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78731310
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78043669
120* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75443678
121CHD1_26751641_Chip-Seq_LNCaP_Human0.74263312
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.73667660
123HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72866797
124EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.71638831
125GATA4_21415370_ChIP-Seq_HL-1_Mouse0.69436368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.28450215
2MP0004957_abnormal_blastocyst_morpholog4.26581088
3MP0010094_abnormal_chromosome_stability3.98065503
4MP0003111_abnormal_nucleus_morphology3.88096072
5MP0003077_abnormal_cell_cycle3.67366362
6MP0010352_gastrointestinal_tract_polyps3.01806490
7MP0008007_abnormal_cellular_replicative2.86284513
8MP0008058_abnormal_DNA_repair2.78594816
9MP0008057_abnormal_DNA_replication2.74117223
10MP0001730_embryonic_growth_arrest2.49942039
11MP0003123_paternal_imprinting2.46096387
12MP0008932_abnormal_embryonic_tissue2.44206616
13MP0010307_abnormal_tumor_latency2.31919664
14MP0003705_abnormal_hypodermis_morpholog2.28791949
15MP0000350_abnormal_cell_proliferation2.22818473
16MP0002396_abnormal_hematopoietic_system2.09844464
17MP0003786_premature_aging1.86217780
18MP0001672_abnormal_embryogenesis/_devel1.83914887
19MP0005380_embryogenesis_phenotype1.83914887
20MP0001697_abnormal_embryo_size1.76533429
21MP0003950_abnormal_plasma_membrane1.72846759
22MP0003984_embryonic_growth_retardation1.72610481
23MP0003806_abnormal_nucleotide_metabolis1.71954257
24MP0002088_abnormal_embryonic_growth/wei1.69113075
25MP0002080_prenatal_lethality1.64613142
26MP0004197_abnormal_fetal_growth/weight/1.64493510
27MP0010030_abnormal_orbit_morphology1.63160402
28MP0002086_abnormal_extraembryonic_tissu1.56724942
29MP0004808_abnormal_hematopoietic_stem1.53174208
30MP0003566_abnormal_cell_adhesion1.50277988
31MP0002084_abnormal_developmental_patter1.49076886
32MP0006035_abnormal_mitochondrial_morpho1.48693532
33MP0003718_maternal_effect1.48561888
34MP0004272_abnormal_basement_membrane1.48184024
35MP0000490_abnormal_crypts_of1.45423605
36MP0002085_abnormal_embryonic_tissue1.45208264
37MP0005076_abnormal_cell_differentiation1.44052908
38MP0003567_abnormal_fetal_cardiomyocyte1.38513642
39MP0005023_abnormal_wound_healing1.38498222
40MP0008877_abnormal_DNA_methylation1.33711875
41MP0000313_abnormal_cell_death1.32693663
42MP0005408_hypopigmentation1.30872667
43MP0002019_abnormal_tumor_incidence1.29539963
44MP0009053_abnormal_anal_canal1.28683695
45MP0002938_white_spotting1.28230311
46MP0009333_abnormal_splenocyte_physiolog1.27613037
47MP0010234_abnormal_vibrissa_follicle1.24809226
48MP0006054_spinal_hemorrhage1.22549841
49MP0000537_abnormal_urethra_morphology1.21458824
50MP0001661_extended_life_span1.14061674
51MP0002102_abnormal_ear_morphology1.12879454
52MP0005397_hematopoietic_system_phenotyp1.11830116
53MP0001545_abnormal_hematopoietic_system1.11830116
54MP0003121_genomic_imprinting1.09734545
55MP0002697_abnormal_eye_size1.07817730
56MP0000358_abnormal_cell_content/1.06387837
57MP0006036_abnormal_mitochondrial_physio1.05737053
58MP0002233_abnormal_nose_morphology1.05583602
59MP0002877_abnormal_melanocyte_morpholog1.04988764
60MP0003941_abnormal_skin_development1.04828645
61MP0001286_abnormal_eye_development1.03935459
62MP0008438_abnormal_cutaneous_collagen1.03811518
63MP0000647_abnormal_sebaceous_gland1.03434101
64MP0003890_abnormal_embryonic-extraembry1.03431520
65MP0004233_abnormal_muscle_weight1.01647503
66MP0000858_altered_metastatic_potential1.00297938
67MP0004264_abnormal_extraembryonic_tissu0.96872037
68MP0003221_abnormal_cardiomyocyte_apopto0.96794171
69MP0001299_abnormal_eye_distance/0.96689967
70MP0005623_abnormal_meninges_morphology0.95885842
71MP0001529_abnormal_vocalization0.95481101
72MP0003385_abnormal_body_wall0.94705174
73MP0003186_abnormal_redox_activity0.94638006
74MP0000750_abnormal_muscle_regeneration0.94341360
75MP0005395_other_phenotype0.93375050
76MP0003755_abnormal_palate_morphology0.92891242
77MP0002796_impaired_skin_barrier0.91943362
78MP0001293_anophthalmia0.90066724
79MP0005384_cellular_phenotype0.89511566
80MP0005621_abnormal_cell_physiology0.87704289
81MP0000762_abnormal_tongue_morphology0.87628177
82MP0000372_irregular_coat_pigmentation0.87478326
83MP0006072_abnormal_retinal_apoptosis0.86366323
84MP0002210_abnormal_sex_determination0.85657736
85MP0002111_abnormal_tail_morphology0.85252587
86MP0003315_abnormal_perineum_morphology0.85233225
87MP0001764_abnormal_homeostasis0.84873896
88MP0006292_abnormal_olfactory_placode0.84643537
89MP0000516_abnormal_urinary_system0.84085935
90MP0005367_renal/urinary_system_phenotyp0.84085935
91MP0000733_abnormal_muscle_development0.83647196
92MP0002060_abnormal_skin_morphology0.83314033
93MP0001915_intracranial_hemorrhage0.83181616
94MP0004147_increased_porphyrin_level0.82502443
95MP0001929_abnormal_gametogenesis0.82304688
96MP0008789_abnormal_olfactory_epithelium0.80905264
97MP0009672_abnormal_birth_weight0.80633568
98MP0000579_abnormal_nail_morphology0.79751877
99MP0004782_abnormal_surfactant_physiolog0.76837182
100MP0002160_abnormal_reproductive_system0.76536860
101MP0001727_abnormal_embryo_implantation0.76378682
102MP0003119_abnormal_digestive_system0.75509460
103MP0000428_abnormal_craniofacial_morphol0.74816198
104MP0004084_abnormal_cardiac_muscle0.74011166
105MP0001145_abnormal_male_reproductive0.73986848
106MP0002722_abnormal_immune_system0.71513790
107MP0003448_altered_tumor_morphology0.71371314
108MP0003937_abnormal_limbs/digits/tail_de0.71200474
109MP0002254_reproductive_system_inflammat0.70621299
110MP0000703_abnormal_thymus_morphology0.70048295
111MP0005275_abnormal_skin_tensile0.70008372
112MP0003935_abnormal_craniofacial_develop0.69364111
113MP0001119_abnormal_female_reproductive0.67716549
114MP0002398_abnormal_bone_marrow0.67520172
115MP0009697_abnormal_copulation0.67484390
116MP0005389_reproductive_system_phenotype0.67406197
117MP0001849_ear_inflammation0.66958681
118MP0001243_abnormal_dermal_layer0.66779716
119MP0002177_abnormal_outer_ear0.66269423
120MP0002234_abnormal_pharynx_morphology0.65828501
121MP0000689_abnormal_spleen_morphology0.65005658
122MP0000627_abnormal_mammary_gland0.64202086
123MP0005257_abnormal_intraocular_pressure0.64153606
124MP0000477_abnormal_intestine_morphology0.63363920
125MP0005501_abnormal_skin_physiology0.62093905
126MP0003283_abnormal_digestive_organ0.61938950
127MP0000653_abnormal_sex_gland0.61305288
128MP0009703_decreased_birth_body0.60464638
129MP0000432_abnormal_head_morphology0.55859974
130MP0002429_abnormal_blood_cell0.55201055
131MP0001853_heart_inflammation0.55113256
132MP0000598_abnormal_liver_morphology0.53484314
133MP0002925_abnormal_cardiovascular_devel0.53041708
134MP0002282_abnormal_trachea_morphology0.52925933
135MP0000371_diluted_coat_color0.52013948
136MP0002269_muscular_atrophy0.52009231
137MP0002092_abnormal_eye_morphology0.51733230

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.48502282
2Abnormality of the anterior horn cell (HP:0006802)3.93200665
3Degeneration of anterior horn cells (HP:0002398)3.93200665
4Increased serum pyruvate (HP:0003542)3.63290026
5Abnormality of glycolysis (HP:0004366)3.53189641
6Selective tooth agenesis (HP:0001592)3.50714274
7Breast hypoplasia (HP:0003187)3.46676977
8Colon cancer (HP:0003003)3.32098002
9Reticulocytopenia (HP:0001896)3.17608585
10Trismus (HP:0000211)3.04886602
11Oral leukoplakia (HP:0002745)3.00340428
12Abnormality of cells of the erythroid lineage (HP:0012130)2.99642588
13Rough bone trabeculation (HP:0100670)2.97069785
14Patellar aplasia (HP:0006443)2.96446814
15Abnormality of methionine metabolism (HP:0010901)2.90471795
16Carpal bone hypoplasia (HP:0001498)2.89735888
17Ependymoma (HP:0002888)2.87931911
18Acute encephalopathy (HP:0006846)2.87023786
19Aplasia/Hypoplasia of the patella (HP:0006498)2.78548289
20Type I transferrin isoform profile (HP:0003642)2.78435911
21Abnormal lung lobation (HP:0002101)2.77595073
22Agnosia (HP:0010524)2.73363601
23Acute necrotizing encephalopathy (HP:0006965)2.69176616
24Abnormal number of erythroid precursors (HP:0012131)2.68465532
25Microvesicular hepatic steatosis (HP:0001414)2.67881694
26Increased hepatocellular lipid droplets (HP:0006565)2.67815450
27Reduced antithrombin III activity (HP:0001976)2.67798183
28Chromsome breakage (HP:0040012)2.67176553
2911 pairs of ribs (HP:0000878)2.64525866
30Multiple enchondromatosis (HP:0005701)2.62750656
31Microretrognathia (HP:0000308)2.59949287
32Deviation of the thumb (HP:0009603)2.59922689
33Medulloblastoma (HP:0002885)2.59913595
34Abnormality of chromosome stability (HP:0003220)2.53524384
35Meckel diverticulum (HP:0002245)2.51925019
36Aplastic anemia (HP:0001915)2.49473425
37Cerebral edema (HP:0002181)2.45843657
38Abnormality of the preputium (HP:0100587)2.42939868
39Abnormality of the calcaneus (HP:0008364)2.42531284
40Proximal placement of thumb (HP:0009623)2.42218918
41Abnormal mitochondria in muscle tissue (HP:0008316)2.41717839
42Glossoptosis (HP:0000162)2.39248903
43Nephroblastoma (Wilms tumor) (HP:0002667)2.38635568
44Increased CSF lactate (HP:0002490)2.38345954
45Embryonal renal neoplasm (HP:0011794)2.37201268
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.36618209
47Abnormal protein N-linked glycosylation (HP:0012347)2.36618209
48Abnormal protein glycosylation (HP:0012346)2.36618209
49Abnormal glycosylation (HP:0012345)2.36618209
50Absent thumb (HP:0009777)2.36348433
51Abnormality of the ileum (HP:0001549)2.34838235
52Lipid accumulation in hepatocytes (HP:0006561)2.34741073
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.34037203
54Neoplasm of the pancreas (HP:0002894)2.33069630
55Hypoplasia of the pons (HP:0012110)2.29784383
56Thrombocytosis (HP:0001894)2.28596322
57Protrusio acetabuli (HP:0003179)2.28491087
58Rhabdomyosarcoma (HP:0002859)2.28108220
59Abnormality of serum amino acid levels (HP:0003112)2.27980585
60Increased serum lactate (HP:0002151)2.25866229
61Myelodysplasia (HP:0002863)2.24842860
62Cervical subluxation (HP:0003308)2.23424915
63Abnormality of alanine metabolism (HP:0010916)2.22829108
64Hyperalaninemia (HP:0003348)2.22829108
65Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22829108
66Missing ribs (HP:0000921)2.21089933
67Absent radius (HP:0003974)2.20415489
68Microglossia (HP:0000171)2.18829801
69Progressive macrocephaly (HP:0004481)2.17473201
70Abnormality of aspartate family amino acid metabolism (HP:0010899)2.17153495
71Cerebral hypomyelination (HP:0006808)2.16307643
72Spinal muscular atrophy (HP:0007269)2.15922878
73Atrophy/Degeneration involving motor neurons (HP:0007373)2.15538234
74Premature graying of hair (HP:0002216)2.15275498
75Entropion (HP:0000621)2.15017287
76Hypoplastic pelvis (HP:0008839)2.14832422
77Impulsivity (HP:0100710)2.13546056
78Abnormalities of placenta or umbilical cord (HP:0001194)2.12920150
79Abnormal trabecular bone morphology (HP:0100671)2.12067261
80Cutaneous melanoma (HP:0012056)2.11938338
81Hypobetalipoproteinemia (HP:0003563)2.11888049
82Slender long bone (HP:0003100)2.09182852
83Stenosis of the external auditory canal (HP:0000402)2.08772970
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.08764216
85Pallor (HP:0000980)2.08488134
86Atresia of the external auditory canal (HP:0000413)2.06289205
87Abnormality of the fetal cardiovascular system (HP:0010948)2.06057819
88Abnormal umbilical cord blood vessels (HP:0011403)2.06057819
89Single umbilical artery (HP:0001195)2.06057819
90Secondary amenorrhea (HP:0000869)2.05050277
91Macrocytic anemia (HP:0001972)2.04522517
92Abnormality of the labia minora (HP:0012880)2.03361800
93Duodenal stenosis (HP:0100867)2.01458082
94Small intestinal stenosis (HP:0012848)2.01458082
95Bone marrow hypocellularity (HP:0005528)2.00107499
96Aplasia involving forearm bones (HP:0009822)2.00075775
97Absent forearm bone (HP:0003953)2.00075775
98Amniotic constriction ring (HP:0009775)1.98519675
99Abnormality of placental membranes (HP:0011409)1.98519675
100Irregular epiphyses (HP:0010582)1.97538773
101Horseshoe kidney (HP:0000085)1.97434077
102Postnatal microcephaly (HP:0005484)1.97363105
103Abnormality of the umbilical cord (HP:0010881)1.97297240
104Mitochondrial inheritance (HP:0001427)1.96613635
105Short middle phalanx of the 5th finger (HP:0004220)1.96426237
106Squamous cell carcinoma (HP:0002860)1.94914506
107Volvulus (HP:0002580)1.94176152
108Lactic acidosis (HP:0003128)1.93114260
109Short palpebral fissure (HP:0012745)1.91988909
110Hyperglycinemia (HP:0002154)1.90589770
111Abnormality of the pons (HP:0007361)1.89984049
112Premature ovarian failure (HP:0008209)1.89872787
113Ankle contracture (HP:0006466)1.89508421
114Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88968752
115Facial cleft (HP:0002006)1.88536148
116Astrocytoma (HP:0009592)1.87026007
117Abnormality of the astrocytes (HP:0100707)1.87026007
118Basal cell carcinoma (HP:0002671)1.86248723
119Hepatocellular necrosis (HP:0001404)1.85579665
120Megaloblastic anemia (HP:0001889)1.84701845
121Bifid tongue (HP:0010297)1.84576752
122Biliary tract neoplasm (HP:0100574)1.84317294
123Amaurosis fugax (HP:0100576)1.82957630
124Ureteral duplication (HP:0000073)1.82886484
125Glioma (HP:0009733)1.82179828
126Pelvic girdle muscle weakness (HP:0003749)1.81768227
127Premature rupture of membranes (HP:0001788)1.81128824
128Stillbirth (HP:0003826)1.80807166
129Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.79877024
130Sparse eyelashes (HP:0000653)1.79740055
131Sloping forehead (HP:0000340)1.79573926
132Tracheoesophageal fistula (HP:0002575)1.78340869
133Spastic diplegia (HP:0001264)1.77340246
134Breast carcinoma (HP:0003002)1.76847149
135Freckling (HP:0001480)1.76667416
136Spinal cord lesions (HP:0100561)1.76483386
137Syringomyelia (HP:0003396)1.76483386
138Aplasia/hypoplasia of the humerus (HP:0006507)1.75897571
139Abnormality of the distal phalanges of the toes (HP:0010182)1.75523993
140Hepatic necrosis (HP:0002605)1.75473400
141Abnormal biliary tract morphology (HP:0012440)1.72226816
142Fused cervical vertebrae (HP:0002949)1.71049151
143Vertebral compression fractures (HP:0002953)1.70709465
144Cortical dysplasia (HP:0002539)1.70517261
145Neoplasm of the colon (HP:0100273)1.70084656
146Increased density of long bones (HP:0006392)1.69604679
147Abnormality of the duodenum (HP:0002246)1.69381191
148Neoplasm of the adrenal gland (HP:0100631)1.69133151
149Ovarian neoplasm (HP:0100615)1.68961820
150Posterior subcapsular cataract (HP:0007787)1.68454225
151Cellular immunodeficiency (HP:0005374)1.67476119
152Increased nuchal translucency (HP:0010880)1.66899009
153Ectopic kidney (HP:0000086)1.66367127
154Metaphyseal cupping (HP:0003021)1.65128701
155Cleft eyelid (HP:0000625)1.62530284
156Renal Fanconi syndrome (HP:0001994)1.59473884
157Hypolipoproteinemia (HP:0010981)1.58601942
158Overlapping toe (HP:0001845)1.58081107
159Methylmalonic acidemia (HP:0002912)1.57621438
160Choanal atresia (HP:0000453)1.56700974
161Neoplasm of the small intestine (HP:0100833)1.53796577
162Proximal tubulopathy (HP:0000114)1.53062057

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.78445377
2BUB13.68525196
3CDC73.63725129
4EIF2AK13.36019116
5NME22.60964220
6TSSK62.60057924
7NEK12.56786656
8NEK22.39290802
9BRSK22.34631665
10EPHA22.26790478
11TTK2.13726708
12PASK2.11475419
13SRPK12.11439874
14EIF2AK32.11280017
15PLK41.89307706
16RPS6KA41.86061403
17VRK21.85644827
18TRIM281.84439434
19PLK11.82147255
20ACVR1B1.81710351
21RPS6KB21.80006506
22PLK31.71522728
23SCYL21.70768536
24TAF11.64407086
25MKNK11.61107111
26AURKB1.59601087
27TESK21.50404413
28ATR1.43369983
29CDK121.41090108
30MAP3K81.41049096
31CDK71.40042189
32TESK11.38530164
33PKN21.30871009
34STK101.29096974
35ZAK1.26636488
36MAP3K121.22714600
37PAK41.21430186
38BRSK11.21136686
39EEF2K1.20480748
40TGFBR11.19361087
41VRK11.18600928
42BCR1.17364494
43ERBB41.16498171
44NUAK11.14319416
45MST1R1.13717350
46CHEK21.12642358
47CHEK11.08377957
48PIM21.08363662
49AURKA1.07424170
50CDK41.06927193
51MAP3K31.02320703
52STK30.98593837
53WNK30.97522088
54MKNK20.97325669
55PLK20.96552426
56STK38L0.96055678
57LRRK20.93978075
58CSNK1G10.93901945
59MAP2K30.92801643
60DYRK30.91656160
61LATS20.90445963
62PIM10.89961657
63LATS10.89326208
64PNCK0.89250676
65BRD40.87391585
66MAP4K20.87257793
67BMPR1B0.86790215
68LIMK10.85991511
69STK160.84488598
70PBK0.82078246
71PDK30.81239508
72PDK40.81239508
73FLT30.79927660
74TNIK0.78521536
75CCNB10.76434809
76TLK10.76368147
77MET0.75885903
78ALK0.75702908
79CLK10.74317265
80MAP3K110.73742684
81ATM0.73685524
82CDK60.73180431
83TTN0.72156584
84NEK90.72111588
85CDK20.72008173
86KDR0.70263022
87CSNK2A20.68194131
88MST40.68045810
89PAK10.66199664
90NME10.64303946
91STK40.64131353
92STK390.62687952
93CSNK2A10.61163357
94EIF2AK20.59466837
95MAPKAPK30.58548525
96TAOK20.58049402
97PAK20.57597555
98PRKCI0.55286394
99MELK0.55060871
100CSNK1G30.54196441
101CDK80.53118734
102MAP3K40.52626102
103ERBB30.52134739
104MTOR0.51013745
105CDK10.50810065
106CDK190.50792182
107PDK20.49735105
108AKT30.48698966
109MAP3K100.47800647
110CDK30.46455416
111FGFR10.45913237
112CSNK1A1L0.45445039
113TRIB30.45156098
114MARK30.44915695
115MAP3K50.42441852
116CSNK1G20.41600786
117STK240.40688265
118NLK0.39682672
119CSNK1E0.38702518
120ZAP700.38189740
121MAPKAPK50.38034045
122BRAF0.37796935
123AKT20.37537145
124FER0.37208836
125DDR20.34302462
126MAP2K70.32835828
127ILK0.32802913
128PTK20.32140948
129MUSK0.31814358
130BMX0.28480461
131ABL20.27806169

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24907135
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.07748256
3Proteasome_Homo sapiens_hsa030503.79525611
4Mismatch repair_Homo sapiens_hsa034303.60465583
5RNA transport_Homo sapiens_hsa030133.41852761
6Spliceosome_Homo sapiens_hsa030403.16969032
7RNA polymerase_Homo sapiens_hsa030203.09551817
8Ribosome_Homo sapiens_hsa030102.96850235
9* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89149043
10One carbon pool by folate_Homo sapiens_hsa006702.86553627
11Nucleotide excision repair_Homo sapiens_hsa034202.69104532
12Cell cycle_Homo sapiens_hsa041102.66050193
13Base excision repair_Homo sapiens_hsa034102.51901039
14Homologous recombination_Homo sapiens_hsa034402.30522445
15Pyrimidine metabolism_Homo sapiens_hsa002402.27144312
16RNA degradation_Homo sapiens_hsa030181.89196080
17Basal transcription factors_Homo sapiens_hsa030221.81440931
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.79013282
19p53 signaling pathway_Homo sapiens_hsa041151.77250497
20Propanoate metabolism_Homo sapiens_hsa006401.73141876
21Pyruvate metabolism_Homo sapiens_hsa006201.72497227
22Fanconi anemia pathway_Homo sapiens_hsa034601.70008388
23Non-homologous end-joining_Homo sapiens_hsa034501.64658656
24mRNA surveillance pathway_Homo sapiens_hsa030151.61391959
25Steroid biosynthesis_Homo sapiens_hsa001001.53269608
26Fatty acid elongation_Homo sapiens_hsa000621.50212959
27Oxidative phosphorylation_Homo sapiens_hsa001901.33618542
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31609242
29Parkinsons disease_Homo sapiens_hsa050121.29495091
30Epstein-Barr virus infection_Homo sapiens_hsa051691.29424064
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22530831
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20758375
33Purine metabolism_Homo sapiens_hsa002301.14809881
34Antigen processing and presentation_Homo sapiens_hsa046121.14049042
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.10419570
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09517662
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07635235
38Biosynthesis of amino acids_Homo sapiens_hsa012301.05955649
39Viral carcinogenesis_Homo sapiens_hsa052031.04814353
40Legionellosis_Homo sapiens_hsa051340.99452313
41Selenocompound metabolism_Homo sapiens_hsa004500.97321667
42Sulfur metabolism_Homo sapiens_hsa009200.93904816
43Pentose phosphate pathway_Homo sapiens_hsa000300.93724571
44Systemic lupus erythematosus_Homo sapiens_hsa053220.92810847
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90763960
46Herpes simplex infection_Homo sapiens_hsa051680.89818533
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88913315
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.87995024
49Oocyte meiosis_Homo sapiens_hsa041140.82699679
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80965771
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.80831285
52Protein export_Homo sapiens_hsa030600.79464197
53Folate biosynthesis_Homo sapiens_hsa007900.77437858
54HTLV-I infection_Homo sapiens_hsa051660.76592854
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75703658
56MicroRNAs in cancer_Homo sapiens_hsa052060.74131301
57Thyroid cancer_Homo sapiens_hsa052160.73422564
58Fatty acid metabolism_Homo sapiens_hsa012120.70244693
59Carbon metabolism_Homo sapiens_hsa012000.70224253
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.69696283
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69311829
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67897555
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66167134
64Small cell lung cancer_Homo sapiens_hsa052220.65067387
65Sulfur relay system_Homo sapiens_hsa041220.64985503
66Arginine and proline metabolism_Homo sapiens_hsa003300.64634982
67Alzheimers disease_Homo sapiens_hsa050100.64151883
68Fructose and mannose metabolism_Homo sapiens_hsa000510.62500867
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59420265
70TGF-beta signaling pathway_Homo sapiens_hsa043500.56863433
71Galactose metabolism_Homo sapiens_hsa000520.56254425
72Adherens junction_Homo sapiens_hsa045200.55748860
73Apoptosis_Homo sapiens_hsa042100.55575569
74Bladder cancer_Homo sapiens_hsa052190.55469516
75Vitamin B6 metabolism_Homo sapiens_hsa007500.54502631
76N-Glycan biosynthesis_Homo sapiens_hsa005100.53491545
77Shigellosis_Homo sapiens_hsa051310.53319263
78Fatty acid degradation_Homo sapiens_hsa000710.53228752
79Peroxisome_Homo sapiens_hsa041460.52371191
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.51902632
81Hippo signaling pathway_Homo sapiens_hsa043900.49843683
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49508505
83Glutathione metabolism_Homo sapiens_hsa004800.49079657
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48718660
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48598646
86HIF-1 signaling pathway_Homo sapiens_hsa040660.47663710
87Arginine biosynthesis_Homo sapiens_hsa002200.47662896
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43660659
89Viral myocarditis_Homo sapiens_hsa054160.43284653
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41855352
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.40740435
92Measles_Homo sapiens_hsa051620.40366450
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.40240028
94Hepatitis B_Homo sapiens_hsa051610.38950793
95Chronic myeloid leukemia_Homo sapiens_hsa052200.37736593
96Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37209007
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36996672
98Vitamin digestion and absorption_Homo sapiens_hsa049770.36724992
99Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36542009
100Caffeine metabolism_Homo sapiens_hsa002320.35871101
101Influenza A_Homo sapiens_hsa051640.34384252
102Butanoate metabolism_Homo sapiens_hsa006500.34242151
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33926261
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32777230
105Proteoglycans in cancer_Homo sapiens_hsa052050.31912306
106Fat digestion and absorption_Homo sapiens_hsa049750.31230626
107Renin-angiotensin system_Homo sapiens_hsa046140.30476332
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29285475
109mTOR signaling pathway_Homo sapiens_hsa041500.29187031
110Colorectal cancer_Homo sapiens_hsa052100.27838250
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.27730461
112Vibrio cholerae infection_Homo sapiens_hsa051100.26833195
113Primary bile acid biosynthesis_Homo sapiens_hsa001200.25069156
114Tryptophan metabolism_Homo sapiens_hsa003800.24182459
115Huntingtons disease_Homo sapiens_hsa050160.24080027
116Lysine degradation_Homo sapiens_hsa003100.23665366
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23481559
118beta-Alanine metabolism_Homo sapiens_hsa004100.22488748
119Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21736341
120Sphingolipid metabolism_Homo sapiens_hsa006000.20418661
121Hematopoietic cell lineage_Homo sapiens_hsa046400.19876023
122Retinol metabolism_Homo sapiens_hsa008300.19060448
123Wnt signaling pathway_Homo sapiens_hsa043100.18355230
124Pathways in cancer_Homo sapiens_hsa052000.17361906
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17260649
126Hedgehog signaling pathway_Homo sapiens_hsa043400.17242457
127Tight junction_Homo sapiens_hsa045300.16926096
128Leishmaniasis_Homo sapiens_hsa051400.16303683
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15693641
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.15626147
131Basal cell carcinoma_Homo sapiens_hsa052170.15170052
132ECM-receptor interaction_Homo sapiens_hsa045120.14823663
133Prostate cancer_Homo sapiens_hsa052150.14228410
134Melanoma_Homo sapiens_hsa052180.13749609
135Metabolic pathways_Homo sapiens_hsa011000.13453116
136Alcoholism_Homo sapiens_hsa050340.11056732
137Focal adhesion_Homo sapiens_hsa045100.10945007

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