RARRES1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.26991361
2L-phenylalanine catabolic process (GO:0006559)7.26991361
3L-phenylalanine metabolic process (GO:0006558)6.94504695
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.94504695
5aromatic amino acid family catabolic process (GO:0009074)6.52323228
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.12060982
7bile acid biosynthetic process (GO:0006699)5.93917731
8indole-containing compound catabolic process (GO:0042436)5.92305238
9indolalkylamine catabolic process (GO:0046218)5.92305238
10tryptophan catabolic process (GO:0006569)5.92305238
11kynurenine metabolic process (GO:0070189)5.87717590
12alpha-linolenic acid metabolic process (GO:0036109)5.67542670
13angiotensin maturation (GO:0002003)5.59639974
14tryptophan metabolic process (GO:0006568)5.55786025
15desmosome organization (GO:0002934)5.47842727
16high-density lipoprotein particle remodeling (GO:0034375)5.46244958
17glyoxylate metabolic process (GO:0046487)5.44137823
18urea cycle (GO:0000050)5.38196568
19urea metabolic process (GO:0019627)5.38196568
20negative regulation of fibrinolysis (GO:0051918)5.32600436
21regulation of protein activation cascade (GO:2000257)5.25218681
22peptidyl-glutamic acid carboxylation (GO:0017187)5.21805939
23protein carboxylation (GO:0018214)5.21805939
24complement activation, alternative pathway (GO:0006957)5.21549710
25regulation of fibrinolysis (GO:0051917)5.18527519
26tyrosine metabolic process (GO:0006570)5.12550781
27sulfur amino acid catabolic process (GO:0000098)5.11111782
28cysteine metabolic process (GO:0006534)5.07353027
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02117573
30nitrogen cycle metabolic process (GO:0071941)4.95487324
31regulation of complement activation (GO:0030449)4.95277717
32bile acid metabolic process (GO:0008206)4.94819829
33aromatic amino acid family metabolic process (GO:0009072)4.90810027
34phospholipid efflux (GO:0033700)4.88567568
35reverse cholesterol transport (GO:0043691)4.77151606
36regulation of triglyceride catabolic process (GO:0010896)4.76533559
37serine family amino acid catabolic process (GO:0009071)4.76491208
38regulation of cholesterol esterification (GO:0010872)4.72868220
39positive regulation of respiratory burst (GO:0060267)4.71464813
40plasma lipoprotein particle remodeling (GO:0034369)4.69504534
41protein-lipid complex remodeling (GO:0034368)4.69504534
42macromolecular complex remodeling (GO:0034367)4.69504534
43positive regulation of pseudopodium assembly (GO:0031274)4.61697029
44amino-acid betaine metabolic process (GO:0006577)4.54861875
45acylglycerol homeostasis (GO:0055090)4.50775723
46triglyceride homeostasis (GO:0070328)4.50775723
47regulation of cellular extravasation (GO:0002691)4.47039508
48negative regulation of sterol transport (GO:0032372)4.45519577
49negative regulation of cholesterol transport (GO:0032375)4.45519577
50coenzyme catabolic process (GO:0009109)4.44747956
51homocysteine metabolic process (GO:0050667)4.43723491
52alpha-amino acid catabolic process (GO:1901606)4.37849582
53lysine metabolic process (GO:0006553)4.35755969
54lysine catabolic process (GO:0006554)4.35755969
55bundle of His cell to Purkinje myocyte communication (GO:0086069)4.35079987
56glomerular filtration (GO:0003094)4.34325254
57bile acid and bile salt transport (GO:0015721)4.32171119
58renal filtration (GO:0097205)4.30388913
59cellular ketone body metabolic process (GO:0046950)4.27861831
60benzene-containing compound metabolic process (GO:0042537)4.24809228
61imidazole-containing compound metabolic process (GO:0052803)4.21200396
62plasma lipoprotein particle clearance (GO:0034381)4.18684150
63fibrinolysis (GO:0042730)4.14951261
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.14866383
65indolalkylamine metabolic process (GO:0006586)4.14708307
66cholesterol efflux (GO:0033344)4.12986909
67regulation of pseudopodium assembly (GO:0031272)4.11963774
68cellular glucuronidation (GO:0052695)4.07131275
69amine catabolic process (GO:0009310)4.07110918
70cellular biogenic amine catabolic process (GO:0042402)4.07110918
71glycine metabolic process (GO:0006544)4.04220866
72low-density lipoprotein particle remodeling (GO:0034374)4.03072720
73cellular amino acid catabolic process (GO:0009063)4.02207253
74glutamate metabolic process (GO:0006536)4.00272388
75virion attachment to host cell (GO:0019062)3.97566232
76adhesion of symbiont to host cell (GO:0044650)3.97566232
77ethanol oxidation (GO:0006069)3.97036611
78cellular modified amino acid catabolic process (GO:0042219)3.96753869
79vitamin A metabolic process (GO:0006776)3.88215138
80dicarboxylic acid biosynthetic process (GO:0043650)3.86020763
81serine family amino acid metabolic process (GO:0009069)3.85250658
82regulation of guanylate cyclase activity (GO:0031282)3.85059554
83antimicrobial humoral response (GO:0019730)3.83216029
84antibacterial humoral response (GO:0019731)3.82489541
85plasma lipoprotein particle assembly (GO:0034377)3.81229723
86hemidesmosome assembly (GO:0031581)3.80815285
87arginine metabolic process (GO:0006525)3.78688980
88negative regulation of lipase activity (GO:0060192)3.77107090
89antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.76991270
90aldehyde catabolic process (GO:0046185)3.76578186
91complement activation, classical pathway (GO:0006958)3.74749883
92calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.74397316
93cofactor catabolic process (GO:0051187)3.71150191
94cytolysis (GO:0019835)3.70389385
95regulation of respiratory burst (GO:0060263)3.70215338
96regulation of cholesterol homeostasis (GO:2000188)3.69925716
97ketone body metabolic process (GO:1902224)3.69890884
98complement activation (GO:0006956)3.69167092
99positive regulation of lipid catabolic process (GO:0050996)3.68855993
100positive regulation of lipoprotein lipase activity (GO:0051006)3.67200673
101positive regulation of triglyceride lipase activity (GO:0061365)3.67200673
102glucuronate metabolic process (GO:0019585)3.65361379
103uronic acid metabolic process (GO:0006063)3.65361379
104intestinal absorption (GO:0050892)3.64829496
105blood coagulation, intrinsic pathway (GO:0007597)3.64796292
106protein activation cascade (GO:0072376)3.62279824
107acetyl-CoA metabolic process (GO:0006084)3.62101870
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.62001668
109linoleic acid metabolic process (GO:0043651)3.58746524
110carboxylic acid catabolic process (GO:0046395)3.56833137
111organic acid catabolic process (GO:0016054)3.56833137
112cholesterol homeostasis (GO:0042632)3.56171947
113plasma lipoprotein particle organization (GO:0071827)3.54496057
114very long-chain fatty acid metabolic process (GO:0000038)3.53610053
115serine family amino acid biosynthetic process (GO:0009070)3.53143971
116alkaloid metabolic process (GO:0009820)3.52572123
117very-low-density lipoprotein particle assembly (GO:0034379)3.51786255
118sterol homeostasis (GO:0055092)3.49450612
119phospholipid homeostasis (GO:0055091)3.49342569
120regulation of bile acid biosynthetic process (GO:0070857)3.45860689
121negative regulation of protein activation cascade (GO:2000258)3.45817255
122drug catabolic process (GO:0042737)3.44856922
123adhesion of symbiont to host (GO:0044406)3.43243415
124regulation of vitamin metabolic process (GO:0030656)3.30648625
125NADH metabolic process (GO:0006734)3.25884983
126antigen processing and presentation of endogenous antigen (GO:0019883)3.22826459
127peptide catabolic process (GO:0043171)3.18442420
128cyclooxygenase pathway (GO:0019371)3.14993318
129maintenance of gastrointestinal epithelium (GO:0030277)3.11515182
130positive regulation of Cdc42 GTPase activity (GO:0043089)3.04164055
131regulation of extracellular matrix disassembly (GO:0010715)3.03525139
132eosinophil chemotaxis (GO:0048245)3.01688153
133glycosphingolipid catabolic process (GO:0046479)3.00625166
134O-glycan processing (GO:0016266)2.93520116
135glycolipid catabolic process (GO:0019377)2.91845333
136vitamin transmembrane transport (GO:0035461)2.89013018
137positive regulation of guanylate cyclase activity (GO:0031284)2.85616102
138diterpenoid biosynthetic process (GO:0016102)2.81887159
139barbed-end actin filament capping (GO:0051016)2.77959758
140multicellular organismal water homeostasis (GO:0050891)2.77502390
141regulation of systemic arterial blood pressure by hormone (GO:0001990)2.77422656
142regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.77422656
143endocrine process (GO:0050886)2.77422656
144fat-soluble vitamin biosynthetic process (GO:0042362)2.71397446
145regulation of keratinocyte proliferation (GO:0010837)2.71106097
146basement membrane organization (GO:0071711)2.69845244
147regulation of apoptotic process involved in morphogenesis (GO:1902337)2.68310346
148epithelial cell-cell adhesion (GO:0090136)2.68163561
149receptor guanylyl cyclase signaling pathway (GO:0007168)2.66430585
150fructose metabolic process (GO:0006000)2.66368865
151eosinophil migration (GO:0072677)2.64597616
152oligosaccharide biosynthetic process (GO:0009312)2.64241431
153regulation of apoptotic cell clearance (GO:2000425)2.61959105
154regulation of water loss via skin (GO:0033561)2.61597818
155branching involved in mammary gland duct morphogenesis (GO:0060444)2.57525628
156regulation of systemic arterial blood pressure (GO:0003073)2.55411403
157primary alcohol catabolic process (GO:0034310)2.54767845
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.54377522
159regulation of cGMP biosynthetic process (GO:0030826)2.54371732
160multicellular organismal catabolic process (GO:0044243)2.53073323
161regulation of transforming growth factor beta2 production (GO:0032909)2.52114604
162keratan sulfate catabolic process (GO:0042340)2.51274492
163regulation of transforming growth factor beta1 production (GO:0032908)2.51021343
164transcytosis (GO:0045056)2.47571420
165chronic inflammatory response (GO:0002544)2.47045983
166surfactant homeostasis (GO:0043129)2.46940032
167regulation of necrotic cell death (GO:0010939)2.46761470
168negative regulation of leukocyte chemotaxis (GO:0002689)2.45272488
169peptide hormone processing (GO:0016486)2.43243922
170sexual reproduction (GO:0019953)2.43202547
171Golgi transport vesicle coating (GO:0048200)2.42590099
172COPI coating of Golgi vesicle (GO:0048205)2.42590099
173epithelial structure maintenance (GO:0010669)2.39997181
174multicellular organismal macromolecule metabolic process (GO:0044259)2.39113780
175GDP-mannose metabolic process (GO:0019673)2.38940132
176lipoprotein transport (GO:0042953)2.38901087
177multicellular organismal metabolic process (GO:0044236)2.35602087
178ethanol metabolic process (GO:0006067)2.34252623
179establishment of skin barrier (GO:0061436)2.31353430
180humoral immune response (GO:0006959)2.31019915
181water homeostasis (GO:0030104)2.30733398
182antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.30709415
183phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.30282984
184sphingomyelin metabolic process (GO:0006684)2.30004846
185ceramide catabolic process (GO:0046514)2.29535654
186epoxygenase P450 pathway (GO:0019373)2.29052875
187hormone catabolic process (GO:0042447)2.28868172
188positive regulation of glycoprotein biosynthetic process (GO:0010560)2.28630628
189fibril organization (GO:0097435)2.27832091
190negative regulation of keratinocyte proliferation (GO:0010839)2.27585950
191citrulline biosynthetic process (GO:0019240)2.27329415
192positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.27204507
193phosphatidylserine acyl-chain remodeling (GO:0036150)2.27027881
194negative regulation of leukocyte migration (GO:0002686)2.26954108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.59392764
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.55928155
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.27665527
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.81839808
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.90068667
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.69891187
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.34469346
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.64885728
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.17036169
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.34550129
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.22819404
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14838514
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.8193080
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.97651882
15TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80417663
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79308812
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78420760
18KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.74069080
19HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.69616912
20HTT_18923047_ChIP-ChIP_STHdh_Human1.68364655
21ZNF263_19887448_ChIP-Seq_K562_Human1.56602549
22GATA1_22025678_ChIP-Seq_K562_Human1.55376470
23ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54305480
24CLOCK_20551151_ChIP-Seq_293T_Human1.52254685
25FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.47199288
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.41559622
27PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40445034
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37538261
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.37071293
30SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36393241
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36393241
32RUNX1_27514584_Chip-Seq_MCF-7_Human1.35654003
33GATA2_21666600_ChIP-Seq_HMVEC_Human1.34195701
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33931682
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30597660
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29698395
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.29597339
38KLF5_25053715_ChIP-Seq_YYC3_Human1.29229125
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.29146872
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24112563
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22766428
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20559577
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19239732
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.18197315
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17818224
46ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13396039
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11594697
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11317944
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08796244
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.08403657
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08399676
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08046259
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06474533
54BP1_19119308_ChIP-ChIP_Hs578T_Human1.06278664
55NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04840309
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.01954995
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.01954995
58IRF8_27001747_Chip-Seq_BMDM_Mouse0.96577261
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94912694
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93927411
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92652543
62TP63_22573176_ChIP-Seq_HFKS_Human0.92648421
63ESR1_21235772_ChIP-Seq_MCF-7_Human0.92123647
64TCF4_18268006_ChIP-ChIP_LS174T_Human0.91928104
65SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89293000
66BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89048141
67* GATA4_25053715_ChIP-Seq_YYC3_Human0.88978006
68SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88457962
69VDR_24787735_ChIP-Seq_THP-1_Human0.88423421
70ATF3_27146783_Chip-Seq_COLON_Human0.88314958
71GATA1_19941826_ChIP-Seq_K562_Human0.86662254
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86445781
73DNAJC2_21179169_ChIP-ChIP_NT2_Human0.86280582
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86134115
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.85344993
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85297212
77UBF1/2_26484160_Chip-Seq_HMECs_Human0.83573388
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.83319615
79NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81990601
80NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81990601
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80217969
82FOXO3_23340844_ChIP-Seq_DLD1_Human0.78968910
83ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78370283
84P63_26484246_Chip-Seq_KERATINOCYTES_Human0.77254609
85EGR1_19032775_ChIP-ChIP_M12_Human0.76411088
86BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.76039959
87* BCAT_22108803_ChIP-Seq_LS180_Human0.72484372
88TAF15_26573619_Chip-Seq_HEK293_Human0.72267241
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72040148
90AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69483347
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.69329144
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69126882
93ESR1_20079471_ChIP-ChIP_T-47D_Human0.69074136
94SOX9_24532713_ChIP-Seq_HFSC_Mouse0.69034267
95ERG_21242973_ChIP-ChIP_JURKAT_Human0.68534281
96* SOX2_20726797_ChIP-Seq_SW620_Human0.68506693
97LXR_22292898_ChIP-Seq_THP-1_Human0.67944552
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67333751
99CEBPB_22108803_ChIP-Seq_LS180_Human0.66338908
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.65849278
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65219525
102STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.63877569
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63253137
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60769620
105SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60544189
106TRIM28_21343339_ChIP-Seq_HEK293_Human0.60030907
107SALL4_18804426_ChIP-ChIP_XEN_Mouse0.59886503
108TP63_23658742_ChIP-Seq_EP156T_Human0.59149997
109SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58892111
110GATA3_24758297_ChIP-Seq_MCF-7_Human0.58584968
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.58029467
112* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.57707275
113P53_21459846_ChIP-Seq_SAOS-2_Human0.57623941
114MYC_19915707_ChIP-ChIP_AK7_Human0.57328560
115AR_20517297_ChIP-Seq_VCAP_Human0.55525164
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55086228
117* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.54862858
118FOXA1_25552417_ChIP-Seq_VCAP_Human0.54336057
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53809119
120ESET_19884257_ChIP-Seq_ESCs_Mouse0.53306381
121RARA_24833708_ChIP-Seq_LIVER_Mouse0.53078321
122CTCF_27219007_Chip-Seq_Bcells_Human0.52815257
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50478976
124CBP_21632823_ChIP-Seq_H3396_Human0.50403590
125TAF2_19829295_ChIP-Seq_ESCs_Human0.49875508
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.49589301
127P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.49164206
128RARB_24833708_ChIP-Seq_LIVER_Mouse0.48585603
129GATA6_25053715_ChIP-Seq_YYC3_Human0.48543754
130* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48194944
131SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.46691522
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.46338144
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.45622671
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.45113503
135CDX2_22108803_ChIP-Seq_LS180_Human0.44783168
136STAT1_17558387_ChIP-Seq_HELA_Human0.44697978
137FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44646377
138RACK7_27058665_Chip-Seq_MCF-7_Human0.44224752
139* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.44081818
140* CJUN_26792858_Chip-Seq_BT549_Human0.43189140
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.43088839
142GATA2_19941826_ChIP-Seq_K562_Human0.43023468
143CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.43021672
144IRF8_22096565_ChIP-ChIP_GC-B_Human0.42658818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.93881824
2MP0005360_urolithiasis7.07199019
3MP0005085_abnormal_gallbladder_physiolo6.27501682
4MP0005365_abnormal_bile_salt5.89460922
5MP0008875_abnormal_xenobiotic_pharmacok4.69429477
6MP0003806_abnormal_nucleotide_metabolis4.05714698
7MP0003252_abnormal_bile_duct3.69674160
8MP0010329_abnormal_lipoprotein_level3.41720564
9MP0005083_abnormal_biliary_tract3.25326263
10MP0009840_abnormal_foam_cell3.13180713
11MP0008438_abnormal_cutaneous_collagen3.07660966
12MP0010352_gastrointestinal_tract_polyps2.88376824
13MP0010155_abnormal_intestine_physiology2.63800665
14MP0003195_calcinosis2.55149310
15MP0005332_abnormal_amino_acid2.53792776
16MP0001666_abnormal_nutrient_absorption2.51288994
17MP0003191_abnormal_cellular_cholesterol2.43174750
18MP0004264_abnormal_extraembryonic_tissu2.40773967
19MP0004858_abnormal_nervous_system2.32178013
20MP0005451_abnormal_body_composition2.20371336
21MP0002796_impaired_skin_barrier2.19627938
22MP0002118_abnormal_lipid_homeostasis2.02517459
23MP0004019_abnormal_vitamin_homeostasis2.00338255
24MP0003724_increased_susceptibility_to1.99632460
25MP0000609_abnormal_liver_physiology1.98220097
26MP0003183_abnormal_peptide_metabolism1.93840662
27MP0005058_abnormal_lysosome_morphology1.89484368
28MP0005023_abnormal_wound_healing1.81223586
29MP0003868_abnormal_feces_composition1.78918230
30MP0008004_abnormal_stomach_pH1.74568827
31MP0005409_darkened_coat_color1.70447037
32MP0002138_abnormal_hepatobiliary_system1.65532857
33MP0005319_abnormal_enzyme/_coenzyme1.63990009
34MP0003300_gastrointestinal_ulcer1.63832589
35MP0009697_abnormal_copulation1.63321981
36MP0005257_abnormal_intraocular_pressure1.62802962
37MP0003279_aneurysm1.62759257
38MP0003011_delayed_dark_adaptation1.60640269
39MP0004272_abnormal_basement_membrane1.57851163
40MP0002254_reproductive_system_inflammat1.54112931
41MP0003866_abnormal_defecation1.52844983
42MP0000678_abnormal_parathyroid_gland1.51762116
43MP0000566_synostosis1.51456006
44MP0003705_abnormal_hypodermis_morpholog1.50996436
45MP0003303_peritoneal_inflammation1.49861134
46MP0005503_abnormal_tendon_morphology1.42848103
47MP0005584_abnormal_enzyme/coenzyme_acti1.42751490
48MP0009785_altered_susceptibility_to1.40088442
49MP0001849_ear_inflammation1.39855150
50MP0003566_abnormal_cell_adhesion1.39411585
51MP0003448_altered_tumor_morphology1.39375137
52MP0010234_abnormal_vibrissa_follicle1.36611632
53MP0001764_abnormal_homeostasis1.35358569
54MP0001664_abnormal_digestion1.35315091
55MP0001533_abnormal_skeleton_physiology1.31571957
56MP0002896_abnormal_bone_mineralization1.31035240
57MP0010678_abnormal_skin_adnexa1.30210474
58MP0001790_abnormal_immune_system1.29505880
59MP0005387_immune_system_phenotype1.29505880
60MP0005647_abnormal_sex_gland1.28729200
61MP0003045_fibrosis1.26557650
62MP0000537_abnormal_urethra_morphology1.25103571
63MP0001958_emphysema1.22476623
64MP0000477_abnormal_intestine_morphology1.21984849
65MP0004381_abnormal_hair_follicle1.21531358
66MP0005275_abnormal_skin_tensile1.20804770
67MP0000604_amyloidosis1.20430844
68MP0006082_CNS_inflammation1.19390892
69MP0000579_abnormal_nail_morphology1.18198759
70MP0003656_abnormal_erythrocyte_physiolo1.15646986
71MP0005165_increased_susceptibility_to1.15244507
72MP0003091_abnormal_cell_migration1.15066671
73MP0001873_stomach_inflammation1.14899941
74MP0009643_abnormal_urine_homeostasis1.10542822
75MP0003186_abnormal_redox_activity1.09829028
76MP0002998_abnormal_bone_remodeling1.09144954
77MP0002148_abnormal_hypersensitivity_rea1.08947334
78MP0000858_altered_metastatic_potential1.08405937
79MP0005164_abnormal_response_to1.07831681
80MP0005025_abnormal_response_to1.07052108
81MP0005501_abnormal_skin_physiology1.06085315
82MP0001845_abnormal_inflammatory_respons1.01451747
83MP0000249_abnormal_blood_vessel1.01183754
84MP0009764_decreased_sensitivity_to0.97782407
85MP0006054_spinal_hemorrhage0.97264776
86MP0002060_abnormal_skin_morphology0.96237103
87MP0000598_abnormal_liver_morphology0.96099912
88MP0001663_abnormal_digestive_system0.96003417
89MP0003329_amyloid_beta_deposits0.95979200
90MP0000490_abnormal_crypts_of0.93741967
91MP0000343_altered_response_to0.90172285
92MP0001835_abnormal_antigen_presentation0.90144694
93MP0005390_skeleton_phenotype0.89287442
94MP0000462_abnormal_digestive_system0.87642537
95MP0000427_abnormal_hair_cycle0.86812706
96MP0005381_digestive/alimentary_phenotyp0.84825513
97MP0001765_abnormal_ion_homeostasis0.83884851
98MP0002876_abnormal_thyroid_physiology0.83794255
99MP0009763_increased_sensitivity_to0.83224396
100MP0005310_abnormal_salivary_gland0.81310599
101MP0000383_abnormal_hair_follicle0.80368170
102MP0000685_abnormal_immune_system0.80250622
103MP0008260_abnormal_autophagy0.80148238
104MP0005636_abnormal_mineral_homeostasis0.79064627
105MP0000465_gastrointestinal_hemorrhage0.78694946
106MP0000627_abnormal_mammary_gland0.78479491
107MP0001881_abnormal_mammary_gland0.77147402
108MP0002166_altered_tumor_susceptibility0.76359290
109MP0009642_abnormal_blood_homeostasis0.75449791
110MP0008469_abnormal_protein_level0.72860313
111MP0002933_joint_inflammation0.72776579
112MP0010368_abnormal_lymphatic_system0.72617375
113MP0001216_abnormal_epidermal_layer0.71063127
114MP0003453_abnormal_keratinocyte_physiol0.70090154
115MP0005408_hypopigmentation0.70064043
116MP0005670_abnormal_white_adipose0.69792834
117MP0010771_integument_phenotype0.69248669
118MP0004947_skin_inflammation0.68820073
119MP0009053_abnormal_anal_canal0.68420843
120MP0005334_abnormal_fat_pad0.65539409
121MP0002078_abnormal_glucose_homeostasis0.64925296
122MP0009765_abnormal_xenobiotic_induced0.64806270
123MP0001661_extended_life_span0.64335260
124MP0006036_abnormal_mitochondrial_physio0.63949245
125MP0002971_abnormal_brown_adipose0.63891524
126MP0000647_abnormal_sebaceous_gland0.61622364
127MP0005535_abnormal_body_temperature0.60456768
128MP0005376_homeostasis/metabolism_phenot0.60066346
129MP0005220_abnormal_exocrine_pancreas0.59165281
130MP0004130_abnormal_muscle_cell0.57791429
131MP0005084_abnormal_gallbladder_morpholo0.57695708
132MP0001243_abnormal_dermal_layer0.57693509
133MP0004782_abnormal_surfactant_physiolog0.57491766
134MP0001756_abnormal_urination0.55075736
135MP0003690_abnormal_glial_cell0.54964890
136MP0000377_abnormal_hair_follicle0.52874372
137MP0009384_cardiac_valve_regurgitation0.52262440
138MP0003638_abnormal_response/metabolism_0.50448648
139MP0006035_abnormal_mitochondrial_morpho0.50312169
140MP0008874_decreased_physiological_sensi0.50177241
141MP0000639_abnormal_adrenal_gland0.49155637
142MP0005448_abnormal_energy_balance0.48015370
143MP0002098_abnormal_vibrissa_morphology0.47698168
144MP0009931_abnormal_skin_appearance0.45379622
145MP0005266_abnormal_metabolism0.44449373
146MP0002837_dystrophic_cardiac_calcinosis0.41340094
147MP0002136_abnormal_kidney_physiology0.40635833
148MP0005666_abnormal_adipose_tissue0.38475119
149MP0002928_abnormal_bile_duct0.37886386
150MP0000230_abnormal_systemic_arterial0.37087141
151MP0002735_abnormal_chemical_nociception0.36978469
152MP0005464_abnormal_platelet_physiology0.35655570
153MP0003436_decreased_susceptibility_to0.35276539
154MP0000467_abnormal_esophagus_morphology0.34918409
155MP0005166_decreased_susceptibility_to0.34206967
156MP0005395_other_phenotype0.34162965
157MP0000367_abnormal_coat/_hair0.34160325
158MP0001191_abnormal_skin_condition0.33892236
159MP0009379_abnormal_foot_pigmentation0.32228326
160MP0003953_abnormal_hormone_level0.31113513
161MP0000538_abnormal_urinary_bladder0.31004692
162MP0004185_abnormal_adipocyte_glucose0.30686030
163MP0003075_altered_response_to0.30404383

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.30542791
2Deep venous thrombosis (HP:0002625)7.15744377
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.07009766
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.44667171
5Xanthomatosis (HP:0000991)6.32470980
6Prolonged partial thromboplastin time (HP:0003645)6.26383002
7Hypobetalipoproteinemia (HP:0003563)6.17131171
8Complement deficiency (HP:0004431)5.42265472
9Hyperlipoproteinemia (HP:0010980)5.41458906
10Hypolipoproteinemia (HP:0010981)4.67425573
11Epidermoid cyst (HP:0200040)4.59526354
12Joint hemorrhage (HP:0005261)4.41228790
13Hyperammonemia (HP:0001987)4.32821667
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.23453953
15Abnormality of the common coagulation pathway (HP:0010990)4.22092726
16Hypoalphalipoproteinemia (HP:0003233)4.14358435
17Fat malabsorption (HP:0002630)4.11321940
18Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09020629
19Hyperglycinemia (HP:0002154)4.08296227
20Abnormality of complement system (HP:0005339)4.03440426
21Abnormality of methionine metabolism (HP:0010901)4.02765349
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.96726679
23Ketosis (HP:0001946)3.91838706
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.91373226
25Hyperglycinuria (HP:0003108)3.68594189
26Abnormality of serine family amino acid metabolism (HP:0010894)3.63437589
27Abnormality of glycine metabolism (HP:0010895)3.63437589
28Pili torti (HP:0003777)3.61570925
29Hypoglycemic coma (HP:0001325)3.60330164
30Conjugated hyperbilirubinemia (HP:0002908)3.56905152
31Abnormality of the intrinsic pathway (HP:0010989)3.50028333
32Alopecia of scalp (HP:0002293)3.47877956
33Abnormality of pyrimidine metabolism (HP:0004353)3.41881917
34Hypercholesterolemia (HP:0003124)3.40872627
35Atrophic scars (HP:0001075)3.24357537
36Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.19159266
37Abnormality of fatty-acid metabolism (HP:0004359)3.15775866
38Steatorrhea (HP:0002570)3.15724522
39Hyperbilirubinemia (HP:0002904)3.11379163
40Premature rupture of membranes (HP:0001788)2.88970893
41Delayed CNS myelination (HP:0002188)2.82795169
42Ketoacidosis (HP:0001993)2.80388921
43Abnormality of the nasal mucosa (HP:0000433)2.79950826
44Recurrent bronchitis (HP:0002837)2.79216803
45Abnormality of nucleobase metabolism (HP:0010932)2.77618457
46Myocardial infarction (HP:0001658)2.77570330
47Abnormality of serum amino acid levels (HP:0003112)2.75361240
48Hyperactive renin-angiotensin system (HP:0000841)2.71992987
49Systemic lupus erythematosus (HP:0002725)2.71804833
50Spontaneous abortion (HP:0005268)2.70874271
51Abnormal hair laboratory examination (HP:0003328)2.70627132
52Cerebral aneurysm (HP:0004944)2.68939239
53Cervical subluxation (HP:0003308)2.68457595
54Neonatal onset (HP:0003623)2.66843372
55Skin nodule (HP:0200036)2.62999553
56Focal segmental glomerulosclerosis (HP:0000097)2.61639740
57Hepatocellular carcinoma (HP:0001402)2.59534206
58Osteolytic defects of the hand bones (HP:0009699)2.58105937
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.58105937
60Cholecystitis (HP:0001082)2.56261391
61Abnormal gallbladder physiology (HP:0012438)2.56261391
62Vascular calcification (HP:0004934)2.53195632
63Hypochromic microcytic anemia (HP:0004840)2.52983933
64Aortic dissection (HP:0002647)2.51854556
65Metabolic acidosis (HP:0001942)2.51060179
66Mitral stenosis (HP:0001718)2.50200601
67Chronic sinusitis (HP:0011109)2.48979136
68Abnormal gallbladder morphology (HP:0012437)2.48373315
69Flattened epiphyses (HP:0003071)2.45959892
70Abnormality of purine metabolism (HP:0004352)2.45486727
71Hyperparathyroidism (HP:0000843)2.45417464
72Dicarboxylic aciduria (HP:0003215)2.43037472
73Abnormality of dicarboxylic acid metabolism (HP:0010995)2.43037472
74Malnutrition (HP:0004395)2.42589855
75Cholelithiasis (HP:0001081)2.42345494
76Chronic diarrhea (HP:0002028)2.42201441
77Nasal polyposis (HP:0100582)2.40559203
78Lethargy (HP:0001254)2.39461014
79Pulmonary artery stenosis (HP:0004415)2.37826961
80Amyloidosis (HP:0011034)2.35871271
81Eczematoid dermatitis (HP:0000976)2.34650838
82Thin bony cortex (HP:0002753)2.34449225
83Glomerulonephritis (HP:0000099)2.30852216
84Abnormality of liposaccharide metabolism (HP:0010968)2.29735640
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.29735640
86Abnormality of glycolipid metabolism (HP:0010969)2.29735640
87Acanthocytosis (HP:0001927)2.28657127
88Chondrocalcinosis (HP:0000934)2.28539681
89Cardiovascular calcification (HP:0011915)2.27658629
90Ileus (HP:0002595)2.25903293
91Cerebral edema (HP:0002181)2.25145734
92Glomerulosclerosis (HP:0000096)2.24050214
93Axonal loss (HP:0003447)2.23766170
94Protrusio acetabuli (HP:0003179)2.21734174
95Interstitial pulmonary disease (HP:0006530)2.21052845
96Abnormality of Sharpey fibers (HP:0100685)2.20621030
97Irritability (HP:0000737)2.20128056
98Recurrent gram-negative bacterial infections (HP:0005420)2.19834609
99Mildly elevated creatine phosphokinase (HP:0008180)2.19306756
100Milia (HP:0001056)2.17593537
101Abnormality of proline metabolism (HP:0010907)2.17157985
102Hydroxyprolinuria (HP:0003080)2.17157985
103Gout (HP:0001997)2.16743306
104Hypoglycemic seizures (HP:0002173)2.15740927
105Sensorimotor neuropathy (HP:0007141)2.15699375
106Spastic diplegia (HP:0001264)2.15627312
107Dysostosis multiplex (HP:0000943)2.15569074
108Bronchitis (HP:0012387)2.15459772
109Late onset (HP:0003584)2.15248221
110Fragile skin (HP:0001030)2.15150224
111Aneurysm (HP:0002617)2.13979905
112Distal lower limb amyotrophy (HP:0008944)2.09890728
113Distal upper limb amyotrophy (HP:0007149)2.08749697
114Upper limb amyotrophy (HP:0009129)2.08749697
115Brushfield spots (HP:0001088)2.04327678
116Pigmentary retinal degeneration (HP:0001146)2.03887448
117Plantar hyperkeratosis (HP:0007556)2.03222655
118Abnormality of the Achilles tendon (HP:0005109)2.02597057
119Abnormality of the gallbladder (HP:0005264)2.02302837
120Vascular tortuosity (HP:0004948)2.01776753
121Arterial tortuosity (HP:0005116)2.01428494
122Bone cyst (HP:0012062)2.01305656
123Aortic aneurysm (HP:0004942)2.01132117
124Urinary glycosaminoglycan excretion (HP:0003541)1.99769939
125Mucopolysacchariduria (HP:0008155)1.99769939
126Abdominal distention (HP:0003270)1.99045002
127Pancreatitis (HP:0001733)1.99031326
128Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.98583680
129Congenital sensorineural hearing impairment (HP:0008527)1.97877615
130Rickets (HP:0002748)1.96737187
131Hypotrichosis (HP:0001006)1.96656744
132Vertebral compression fractures (HP:0002953)1.95821825
133Opisthotonus (HP:0002179)1.93784385
134Vacuolated lymphocytes (HP:0001922)1.93317613
135Segmental peripheral demyelination/remyelination (HP:0003481)1.92907915
136Vomiting (HP:0002013)1.92519805
137Menorrhagia (HP:0000132)1.91853834
138Flat acetabular roof (HP:0003180)1.91568581
139Nephritis (HP:0000123)1.90344872
140Decreased circulating renin level (HP:0003351)1.90201534
141Premature loss of primary teeth (HP:0006323)1.89479172
142Hemorrhage of the eye (HP:0011885)1.89435236
143Spondylolisthesis (HP:0003302)1.88973640
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88591623
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88591623
146Abnormality of polysaccharide metabolism (HP:0011012)1.88591623
147Gingival bleeding (HP:0000225)1.87633284
148Abnormality of the distal phalanges of the toes (HP:0010182)1.87096700
149Enlarged kidneys (HP:0000105)1.86616190
150Esophageal varix (HP:0002040)1.85623487
151Hypoplasia of dental enamel (HP:0006297)1.84848618
152Bone pain (HP:0002653)1.82469514
153Follicular hyperkeratosis (HP:0007502)1.81969874
154Subcapsular cataract (HP:0000523)1.81644233
155Hyperphosphatemia (HP:0002905)1.80421917
156Abnormal glucose tolerance (HP:0001952)1.80103242
157Widely patent fontanelles and sutures (HP:0004492)1.79975801
158Gingivitis (HP:0000230)1.79916198
159Abnormal cartilage morphology (HP:0002763)1.79529000
160Abnormality of renin-angiotensin system (HP:0000847)1.79260188
161Natal tooth (HP:0000695)1.76726915
162Generalized aminoaciduria (HP:0002909)1.75880943
163Hypophosphatemic rickets (HP:0004912)1.75557218
164Loss of speech (HP:0002371)1.75077191
165Thrombophlebitis (HP:0004418)1.74991892
166Hypophosphatemia (HP:0002148)1.74522516
167Emphysema (HP:0002097)1.74066643
168Ventricular tachycardia (HP:0004756)1.73614272
169Coxa vara (HP:0002812)1.73529573
170Distal lower limb muscle weakness (HP:0009053)1.72929209
171Abnormal enzyme/coenzyme activity (HP:0012379)1.72714269
172Hyperinsulinemic hypoglycemia (HP:0000825)1.72605861
173Stroke (HP:0001297)1.72373899
174Abnormality of iron homeostasis (HP:0011031)1.72314492
175Right ventricular cardiomyopathy (HP:0011663)1.71277725
176Status epilepticus (HP:0002133)1.69693669
177Hypotension (HP:0002615)1.69325108
178Abnormality of transition element cation homeostasis (HP:0011030)1.66989847
179Advanced eruption of teeth (HP:0006288)1.66629890
180Ventricular fibrillation (HP:0001663)1.66135724
181Poikilocytosis (HP:0004447)1.65563426
182Abnormality of vitamin metabolism (HP:0100508)1.64516883
183Renal cortical cysts (HP:0000803)1.64008586
184Congenital ichthyosiform erythroderma (HP:0007431)1.63186197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA26.23783374
2BCKDK5.88266680
3FGFR44.40842713
4ERN14.27778705
5SIK13.84420668
6MST1R3.05323741
7ERBB42.61401979
8TESK12.48826052
9MAP2K42.39073419
10MAPKAPK32.33523065
11EPHA32.19340379
12ACVR1B2.09814233
13PIK3CG2.05745914
14INSRR2.03926717
15TAOK31.94462840
16MYLK1.94309247
17DDR21.80241105
18NEK91.67681618
19LATS11.66390151
20PRKG21.60699097
21TRIB31.57826317
22CDC42BPA1.54963522
23STK241.51538806
24MAPK111.49026622
25FGFR21.47394315
26FRK1.46043088
27FER1.42525051
28DAPK21.42393665
29MAP3K31.35421641
30PTK61.34953918
31PKN21.33632168
32MAPKAPK51.32646704
33ABL21.30587156
34TGFBR21.29199487
35TYK21.28402407
36FLT31.28222427
37LATS21.27662867
38MAP3K21.21176183
39MAP3K61.19133161
40MAP3K71.16722225
41PINK11.15942003
42NTRK11.15046167
43MET1.12163060
44PAK41.09917168
45MAP3K111.09421713
46EPHB11.02573453
47RET1.02080073
48FGFR31.01766025
49JAK21.01711330
50MAPK41.00179291
51MAP3K140.99719399
52EPHB20.96218282
53MAP2K30.94077712
54DMPK0.92483813
55STK38L0.92346420
56ERBB20.89638800
57ZAP700.88636995
58CAMK2G0.87086455
59BMX0.86889374
60MAP2K10.86239085
61GRK50.86087626
62KSR20.85715970
63TBK10.85034433
64NME20.83898353
65TAOK10.83417020
66JAK10.81348307
67MAP3K120.80948107
68MAPK120.80740724
69MAP2K60.79067476
70PRKCZ0.78291691
71PRKACG0.77044702
72PRKAA20.76058715
73PTK20.73849319
74PIK3CA0.73611877
75MAP3K10.73284075
76PDGFRB0.72802086
77CDK60.71332784
78DYRK1B0.70668918
79PAK30.70619489
80CSK0.70474879
81TTN0.69815386
82ICK0.68235620
83STK390.67076627
84KDR0.65309885
85IRAK30.63741647
86SMG10.62685018
87KIT0.58343058
88JAK30.58193242
89STK380.57170611
90SGK20.55099062
91SGK30.52807755
92HIPK20.52586372
93NLK0.51897069
94GSK3A0.49701300
95GRK10.48972903
96MAPK150.48425770
97NEK60.48297890
98RIPK10.46752633
99RPS6KA20.45997518
100GRK60.45001331
101MAP2K20.44864306
102PRPF4B0.44438967
103SIK30.44216720
104MAP3K50.42985236
105IGF1R0.42883810
106MAPKAPK20.42347250
107SRC0.41759561
108PIM20.41234841
109TRPM70.40459477
110PRKCQ0.40436697
111BLK0.40114476
112PRKCG0.39163821
113SGK4940.39113505
114SGK2230.39113505
115LMTK20.38901854
116STK30.38497844
117BMPR20.38090196
118ARAF0.37971927
119IRAK10.37487316
120PDPK10.37158588
121PRKAA10.36216898
122CAMK2D0.35605531
123PRKCI0.32882220
124TIE10.32847859
125CAMK1D0.32511135
126MAP3K90.32210842
127PDGFRA0.32184624
128IRAK40.31173024
129IKBKB0.30999546
130MAPK70.29908666
131MAP3K100.29620301
132PRKCA0.29183377
133PRKCD0.28871475
134RPS6KC10.28653569
135RPS6KL10.28653569
136PRKD20.27657147
137BCR0.26576933
138PRKACA0.26335883
139MATK0.26061224
140ROCK10.25551041
141EGFR0.23649117
142CSNK1G10.22791392
143LRRK20.22781661
144MST40.22673429
145FGFR10.22025417
146IKBKE0.21650893
147PKN10.21030734

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.68748847
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.29919023
3Nitrogen metabolism_Homo sapiens_hsa009103.27406819
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18418427
5Arginine biosynthesis_Homo sapiens_hsa002202.93945871
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.76609493
7Complement and coagulation cascades_Homo sapiens_hsa046102.74897324
8Tryptophan metabolism_Homo sapiens_hsa003802.64336489
9Fatty acid degradation_Homo sapiens_hsa000712.55955006
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.53264417
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.38274796
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36698294
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16116756
14Butanoate metabolism_Homo sapiens_hsa006502.13041577
15Peroxisome_Homo sapiens_hsa041462.11166171
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.08665769
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.05168545
18Histidine metabolism_Homo sapiens_hsa003402.01735568
19Chemical carcinogenesis_Homo sapiens_hsa052041.97193736
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95888669
21PPAR signaling pathway_Homo sapiens_hsa033201.94142765
22Fatty acid metabolism_Homo sapiens_hsa012121.90254709
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.89759480
24Propanoate metabolism_Homo sapiens_hsa006401.86967382
25Asthma_Homo sapiens_hsa053101.80400970
26Retinol metabolism_Homo sapiens_hsa008301.79080462
27beta-Alanine metabolism_Homo sapiens_hsa004101.70793321
28Caffeine metabolism_Homo sapiens_hsa002321.69983945
29Staphylococcus aureus infection_Homo sapiens_hsa051501.69882534
30Fatty acid elongation_Homo sapiens_hsa000621.66410232
31Phenylalanine metabolism_Homo sapiens_hsa003601.65546825
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65439398
33Tyrosine metabolism_Homo sapiens_hsa003501.65201680
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.64429821
35Other glycan degradation_Homo sapiens_hsa005111.59019505
36Bile secretion_Homo sapiens_hsa049761.57700452
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57180199
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55061310
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.49891467
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44740111
41Allograft rejection_Homo sapiens_hsa053301.41099815
42Steroid biosynthesis_Homo sapiens_hsa001001.38572116
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36297825
44Selenocompound metabolism_Homo sapiens_hsa004501.34299140
45Pyruvate metabolism_Homo sapiens_hsa006201.34091664
46Cyanoamino acid metabolism_Homo sapiens_hsa004601.33142676
47Sulfur metabolism_Homo sapiens_hsa009201.31737342
48Graft-versus-host disease_Homo sapiens_hsa053321.30077782
49ABC transporters_Homo sapiens_hsa020101.27322808
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.26720859
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26108516
52Autoimmune thyroid disease_Homo sapiens_hsa053201.24494396
53Starch and sucrose metabolism_Homo sapiens_hsa005001.22534420
54Fat digestion and absorption_Homo sapiens_hsa049751.21230438
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14916707
56Folate biosynthesis_Homo sapiens_hsa007901.13438757
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.11403209
58Leishmaniasis_Homo sapiens_hsa051401.11181738
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08556253
60Biosynthesis of amino acids_Homo sapiens_hsa012301.04985937
61Carbon metabolism_Homo sapiens_hsa012001.04497923
62Toxoplasmosis_Homo sapiens_hsa051451.01577009
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01481645
64Lysosome_Homo sapiens_hsa041420.99416766
65Glycosaminoglycan degradation_Homo sapiens_hsa005310.96481706
66Type I diabetes mellitus_Homo sapiens_hsa049400.95451239
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.94431258
68Sulfur relay system_Homo sapiens_hsa041220.91240374
69ECM-receptor interaction_Homo sapiens_hsa045120.89691037
70TNF signaling pathway_Homo sapiens_hsa046680.88107129
71Arginine and proline metabolism_Homo sapiens_hsa003300.86316192
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.85917247
73Antigen processing and presentation_Homo sapiens_hsa046120.83069723
74Sphingolipid metabolism_Homo sapiens_hsa006000.82420120
75Vitamin digestion and absorption_Homo sapiens_hsa049770.82321127
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.81761091
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80498366
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79999860
79Vitamin B6 metabolism_Homo sapiens_hsa007500.79174382
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79045872
81Pancreatic secretion_Homo sapiens_hsa049720.77002956
82Viral myocarditis_Homo sapiens_hsa054160.76400237
83Tuberculosis_Homo sapiens_hsa051520.74935070
84Salmonella infection_Homo sapiens_hsa051320.73737935
85Tight junction_Homo sapiens_hsa045300.72928767
86Glycerolipid metabolism_Homo sapiens_hsa005610.72436590
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69225714
88Fatty acid biosynthesis_Homo sapiens_hsa000610.68900773
89Rheumatoid arthritis_Homo sapiens_hsa053230.67045377
90Lysine degradation_Homo sapiens_hsa003100.66470419
91Glutathione metabolism_Homo sapiens_hsa004800.66287782
92Influenza A_Homo sapiens_hsa051640.64901122
93Notch signaling pathway_Homo sapiens_hsa043300.57455706
94Renin secretion_Homo sapiens_hsa049240.55938777
95Phagosome_Homo sapiens_hsa041450.54630750
96Focal adhesion_Homo sapiens_hsa045100.52877889
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52289089
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52219121
99Pentose phosphate pathway_Homo sapiens_hsa000300.49085256
100Vibrio cholerae infection_Homo sapiens_hsa051100.49062122
101Linoleic acid metabolism_Homo sapiens_hsa005910.47469308
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47019024
103NF-kappa B signaling pathway_Homo sapiens_hsa040640.45732894
104Metabolic pathways_Homo sapiens_hsa011000.45201653
105Hematopoietic cell lineage_Homo sapiens_hsa046400.44822581
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43791519
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43694228
108Prion diseases_Homo sapiens_hsa050200.43683811
109Adherens junction_Homo sapiens_hsa045200.43468796
110Osteoclast differentiation_Homo sapiens_hsa043800.42283192
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41325781
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39902401
113One carbon pool by folate_Homo sapiens_hsa006700.38805954
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.36986779
115Malaria_Homo sapiens_hsa051440.36803321
116Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36332912
117Chemokine signaling pathway_Homo sapiens_hsa040620.34196588
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33133325
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.27049197
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.24820028
121Insulin resistance_Homo sapiens_hsa049310.24219849
122Fructose and mannose metabolism_Homo sapiens_hsa000510.23777555
123Galactose metabolism_Homo sapiens_hsa000520.18033504
124Glucagon signaling pathway_Homo sapiens_hsa049220.09874354
125Arachidonic acid metabolism_Homo sapiens_hsa005900.03625303
126Pertussis_Homo sapiens_hsa05133-0.2355712
127African trypanosomiasis_Homo sapiens_hsa05143-0.2043928
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.1906562
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1837856
130Protein digestion and absorption_Homo sapiens_hsa04974-0.1824491
131Renin-angiotensin system_Homo sapiens_hsa04614-0.1652188
132Amoebiasis_Homo sapiens_hsa05146-0.1593849
133Hepatitis C_Homo sapiens_hsa05160-0.1511359
134Mineral absorption_Homo sapiens_hsa04978-0.1480449
135Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1442242
136Bladder cancer_Homo sapiens_hsa05219-0.1221598
137Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1201618
138Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0960569
139Regulation of autophagy_Homo sapiens_hsa04140-0.0875495
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0557990
141Ether lipid metabolism_Homo sapiens_hsa00565-0.0486370
142Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0443419
143Insulin signaling pathway_Homo sapiens_hsa04910-0.0323472
144AMPK signaling pathway_Homo sapiens_hsa04152-0.0186922
145Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0153774
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0146924

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