RARG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.94252422
2embryonic process involved in female pregnancy (GO:0060136)6.37902319
3establishment of apical/basal cell polarity (GO:0035089)6.21858975
4regulation of integrin activation (GO:0033623)5.68577026
5transcription from mitochondrial promoter (GO:0006390)5.28121749
6establishment or maintenance of monopolar cell polarity (GO:0061339)5.25228174
7establishment of monopolar cell polarity (GO:0061162)5.25228174
8regulation of water loss via skin (GO:0033561)5.03141492
9regulation of posttranscriptional gene silencing (GO:0060147)4.91438155
10regulation of gene silencing by miRNA (GO:0060964)4.91438155
11regulation of gene silencing by RNA (GO:0060966)4.91438155
12proline metabolic process (GO:0006560)4.84420763
13establishment of skin barrier (GO:0061436)4.79500051
14replication fork processing (GO:0031297)4.67382524
15skin morphogenesis (GO:0043589)4.46945870
16regulation of translational fidelity (GO:0006450)4.34621041
17positive regulation of protein homooligomerization (GO:0032464)4.32676754
18embryonic placenta development (GO:0001892)4.21406270
19mitotic G1 DNA damage checkpoint (GO:0031571)4.20099753
20regulation of hippo signaling (GO:0035330)4.16289614
21keratinization (GO:0031424)4.04531341
22apoptotic process involved in morphogenesis (GO:0060561)4.00736361
23Golgi transport vesicle coating (GO:0048200)4.00026761
24COPI coating of Golgi vesicle (GO:0048205)4.00026761
25maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.92868415
26protein heterotrimerization (GO:0070208)3.92792231
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.87601251
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.87601251
29focal adhesion assembly (GO:0048041)3.81301109
30cell-substrate adherens junction assembly (GO:0007045)3.81301109
31adherens junction assembly (GO:0034333)3.80805806
32mitochondrial DNA metabolic process (GO:0032042)3.78838652
33formation of translation preinitiation complex (GO:0001731)3.78774199
34anatomical structure regression (GO:0060033)3.77531154
35regulation of protein homooligomerization (GO:0032462)3.74788163
36mitotic G1/S transition checkpoint (GO:0044819)3.73527474
37trophectodermal cell differentiation (GO:0001829)3.73378798
38DNA deamination (GO:0045006)3.73289475
39paraxial mesoderm development (GO:0048339)3.73046735
40polarized epithelial cell differentiation (GO:0030859)3.72044783
41G1 DNA damage checkpoint (GO:0044783)3.63358253
42oxidative demethylation (GO:0070989)3.61566898
43convergent extension (GO:0060026)3.56413549
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.53569280
45negative regulation of Ras GTPase activity (GO:0034261)3.50665626
46anterior/posterior axis specification, embryo (GO:0008595)3.49401918
47positive regulation of Cdc42 GTPase activity (GO:0043089)3.46449836
48bundle of His cell to Purkinje myocyte communication (GO:0086069)3.43844693
49spliceosomal tri-snRNP complex assembly (GO:0000244)3.42558136
50nodal signaling pathway (GO:0038092)3.32353827
51basement membrane organization (GO:0071711)3.30578043
52bone trabecula formation (GO:0060346)3.29549932
53regulation of sister chromatid cohesion (GO:0007063)3.29211740
54hemidesmosome assembly (GO:0031581)3.29100434
55DNA strand renaturation (GO:0000733)3.28310898
56negative regulation of cell cycle arrest (GO:0071157)3.27931336
57positive regulation of keratinocyte differentiation (GO:0045618)3.27718679
58keratinocyte proliferation (GO:0043616)3.27357790
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.26529196
60dosage compensation (GO:0007549)3.26098721
61negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21044235
62barbed-end actin filament capping (GO:0051016)3.20710061
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.20630150
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.20630150
65positive regulation of mitotic sister chromatid separation (GO:1901970)3.20630150
66atrioventricular valve morphogenesis (GO:0003181)3.18010493
67glial cell migration (GO:0008347)3.17878803
68keratinocyte differentiation (GO:0030216)3.17580034
69protein retention in ER lumen (GO:0006621)3.17444984
70multicellular organismal water homeostasis (GO:0050891)3.15376760
71Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.14932047
72maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12642019
73negative regulation of JAK-STAT cascade (GO:0046426)3.11927946
74mRNA cleavage (GO:0006379)3.11387447
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.10738512
76semaphorin-plexin signaling pathway (GO:0071526)3.10169445
77peptide cross-linking (GO:0018149)3.09871395
78poly(A)+ mRNA export from nucleus (GO:0016973)3.07932012
79regulation of RNA export from nucleus (GO:0046831)3.07537753
80negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.06682428
81positive regulation of SMAD protein import into nucleus (GO:0060391)3.05981126
82apoptotic process involved in development (GO:1902742)3.03822352
83positive regulation of blood vessel endothelial cell migration (GO:0043536)3.03729345
84positive regulation of epidermal cell differentiation (GO:0045606)3.01670075
85pre-miRNA processing (GO:0031054)3.01472736
86positive regulation of protein oligomerization (GO:0032461)2.99948397
87endodermal cell differentiation (GO:0035987)2.99690797
88negative regulation of fatty acid biosynthetic process (GO:0045717)2.99423895
89histone H4-K12 acetylation (GO:0043983)2.98756362
90regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.98377021
91regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.97488244
92regulation of establishment of planar polarity (GO:0090175)2.96866816
93endothelial cell morphogenesis (GO:0001886)2.94789820
94negative regulation of cell fate specification (GO:0009996)2.94780756
95collagen fibril organization (GO:0030199)2.93683331
96vascular endothelial growth factor signaling pathway (GO:0038084)2.91715868
97heterochromatin organization (GO:0070828)2.90228966
98viral mRNA export from host cell nucleus (GO:0046784)2.88547654
99negative regulation of stress fiber assembly (GO:0051497)2.88074719
100regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.88053277
101pinocytosis (GO:0006907)2.85345893
102negative regulation of mRNA processing (GO:0050686)2.84961736
103protein localization to endosome (GO:0036010)2.82260070
104eyelid development in camera-type eye (GO:0061029)2.81891594
105regulation of SMAD protein import into nucleus (GO:0060390)2.81740414
106maternal placenta development (GO:0001893)2.81071856
107positive regulation of epidermis development (GO:0045684)2.80981608
108stress fiber assembly (GO:0043149)2.79460812
109positive regulation of chromosome segregation (GO:0051984)2.78585776
110cell migration involved in heart development (GO:0060973)2.77899998
111DNA integration (GO:0015074)2.75793249
112positive regulation by host of viral transcription (GO:0043923)2.74925161
113activation of Rac GTPase activity (GO:0032863)2.74524617
114kidney mesenchyme development (GO:0072074)2.72969512
115base-excision repair (GO:0006284)2.72569189
116cellular response to ATP (GO:0071318)2.72507263
117muscle cell migration (GO:0014812)2.71928500
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71880115
119determination of adult lifespan (GO:0008340)2.71280067
120establishment of tissue polarity (GO:0007164)2.70331087
121establishment of planar polarity (GO:0001736)2.70331087
122hypotonic response (GO:0006971)2.69792998
123regulation of mammary gland epithelial cell proliferation (GO:0033599)2.69011353
124type B pancreatic cell proliferation (GO:0044342)2.68103071
125pentose-phosphate shunt (GO:0006098)2.67785922
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66406657
127bone morphogenesis (GO:0060349)2.64924281
128epithelial cell-cell adhesion (GO:0090136)2.63668075
129desmosome organization (GO:0002934)2.63605988
130regulation of apoptotic process involved in morphogenesis (GO:1902337)2.62704846
131labyrinthine layer development (GO:0060711)2.62693306
132gap junction assembly (GO:0016264)2.62427318
133lateral sprouting from an epithelium (GO:0060601)2.61047850
134retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.60006293
135regulation of early endosome to late endosome transport (GO:2000641)2.59767718
136mammary gland epithelial cell proliferation (GO:0033598)2.59390926
137regulation of podosome assembly (GO:0071801)2.59119971
138regulation of extracellular matrix disassembly (GO:0010715)2.58905412
139regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58586609
140negative regulation of cell size (GO:0045792)2.58024158
141epidermal cell differentiation (GO:0009913)2.57911151
142regulation of double-strand break repair (GO:2000779)2.57088092
143collagen metabolic process (GO:0032963)2.56318110
144endothelial cell chemotaxis (GO:0035767)2.55875579
145extracellular matrix assembly (GO:0085029)2.55514235
146vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54867909
147intracellular estrogen receptor signaling pathway (GO:0030520)2.54794834
148positive regulation of endothelial cell apoptotic process (GO:2000353)2.53463209
149cochlea morphogenesis (GO:0090103)2.53178593
150regulation of protein oligomerization (GO:0032459)2.53015950
151branching involved in mammary gland duct morphogenesis (GO:0060444)2.52627810
152negative regulation of RNA splicing (GO:0033119)2.52475268
153DNA topological change (GO:0006265)2.52101554
154mitotic sister chromatid segregation (GO:0000070)2.49530267
155extracellular fibril organization (GO:0043206)2.49074731
156nuclear envelope reassembly (GO:0031468)2.48832461
157mitotic nuclear envelope reassembly (GO:0007084)2.48832461
158metanephric mesenchyme development (GO:0072075)2.48776757
159cell-substrate junction assembly (GO:0007044)2.48422066
160proximal/distal pattern formation (GO:0009954)2.48214195
161negative regulation of focal adhesion assembly (GO:0051895)2.47749292
162negative regulation of cell junction assembly (GO:1901889)2.47749292
163negative regulation of adherens junction organization (GO:1903392)2.47749292
164morphogenesis of an epithelial fold (GO:0060571)2.47598153
165extracellular matrix disassembly (GO:0022617)2.47442412
166response to laminar fluid shear stress (GO:0034616)2.47059758
167hippo signaling (GO:0035329)2.46830294
168hair cycle (GO:0042633)2.46011926
169molting cycle (GO:0042303)2.46011926
170negative regulation of stem cell proliferation (GO:2000647)2.45922539
171negative regulation of keratinocyte proliferation (GO:0010839)2.45490883
172non-canonical Wnt signaling pathway (GO:0035567)2.45040109
173notochord development (GO:0030903)2.43915729
174regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.43705986
175establishment or maintenance of apical/basal cell polarity (GO:0035088)2.42926852
176cytoskeletal anchoring at plasma membrane (GO:0007016)2.40228875
177epidermis development (GO:0008544)2.39679669
178response to water (GO:0009415)2.39438283
179collagen catabolic process (GO:0030574)2.39266145
180positive regulation of receptor recycling (GO:0001921)2.36681164
181NADPH regeneration (GO:0006740)2.36353014
182cellular protein complex localization (GO:0034629)2.35958912
183fibril organization (GO:0097435)2.35871364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.07224641
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.60527409
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.60527409
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.60527409
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.24001281
6* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.86683932
7E2F7_22180533_ChIP-Seq_HELA_Human2.71183467
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.69469606
9* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.60042330
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57461859
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.48303464
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.45098573
13POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37079666
14PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.27989304
15* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24566268
16* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.17484090
17ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.14016634
18* TCF3_18692474_ChIP-Seq_MEFs_Mouse2.12669766
19* SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.09435757
20ZNF263_19887448_ChIP-Seq_K562_Human2.09229932
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.03479043
22STAT3_1855785_ChIP-Seq_MESCs_Mouse2.03065078
23* NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.02578226
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00750133
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99430098
26* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.97250351
27SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92234007
28VDR_21846776_ChIP-Seq_THP-1_Human1.90510804
29CLOCK_20551151_ChIP-Seq_293T_Human1.88032551
30* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87754135
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.82185165
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.81644482
33DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.79385428
34MYC_22102868_ChIP-Seq_BL_Human1.74945245
35TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.74183050
36LXR_22292898_ChIP-Seq_THP-1_Human1.73573742
37* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.70883402
38RACK7_27058665_Chip-Seq_MCF-7_Human1.70477907
39* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.68202556
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.67957990
41TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.65256255
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64854317
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64102161
44SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.61604740
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.61604740
46* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.56619787
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.56261278
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.55262980
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52327986
50* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51453622
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51415674
52* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.50973450
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.49630332
54MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47887319
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.42920683
56* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42144885
57FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41901787
58* NANOG_21062744_ChIP-ChIP_HESCs_Human1.41302067
59* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.39355043
60TRIM28_21343339_ChIP-Seq_HEK293_Human1.39056574
61* RUNX1_27514584_Chip-Seq_MCF-7_Human1.38508835
62* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.37624829
63* KDM2B_26808549_Chip-Seq_DND41_Human1.36535751
64HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.36073092
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.35941031
66* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.34931405
67UBF1/2_26484160_Chip-Seq_HMECs_Human1.34440150
68* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34407278
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.34151495
70ATF3_27146783_Chip-Seq_COLON_Human1.33582602
71* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33518696
72CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.32581395
73CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.31924679
74* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.31836238
75P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31201043
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.30934849
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30679603
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30103270
79PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29700529
80* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28558260
81* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.24787809
82* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.21954238
83* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.21777945
84* SA1_27219007_Chip-Seq_ERYTHROID_Human1.21359676
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21136408
86EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.20667815
87ERG_21242973_ChIP-ChIP_JURKAT_Human1.19907059
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18782249
89* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.18555325
90* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.17681578
91KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16901993
92NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15970116
93* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.15350913
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14912795
95* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14320126
96* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14216656
97UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12911281
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12799297
99* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12332560
100KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11064411
101* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08160682
102* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06969280
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.06781826
104CREB1_26743006_Chip-Seq_LNCaP_Human1.06615295
105* KDM2B_26808549_Chip-Seq_JURKAT_Human1.06595555
106* TCF7_22412390_ChIP-Seq_EML_Mouse1.06315843
107SMC1_22415368_ChIP-Seq_MEFs_Mouse1.05750851
108SMC4_20622854_ChIP-Seq_HELA_Human1.05681453
109P68_20966046_ChIP-Seq_HELA_Human1.04873646
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.04364738
111* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03483489
112HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03270505
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03223009
114HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03130615
115SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02606675
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.01366805
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.00717622
118ESR1_20079471_ChIP-ChIP_T-47D_Human1.00648894
119* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00153781
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99527674
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.99514301
122TP53_22127205_ChIP-Seq_IMR90_Human0.99457045
123ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98913331
124* TP63_22573176_ChIP-Seq_HFKS_Human0.98065481
125ESR1_21235772_ChIP-Seq_MCF-7_Human0.97387402
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96605355
127MAF_26560356_Chip-Seq_TH1_Human0.95521811
128SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95343605
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.94859694
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.94240495
131* KDM2B_26808549_Chip-Seq_K562_Human0.94147824
132* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93945695
133* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93259494
134XRN2_22483619_ChIP-Seq_HELA_Human0.92878864
135* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.92814378
136NCOR1_26117541_ChIP-Seq_K562_Human0.92659728
137CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92144735
138DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90922875
139CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90354306
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89818527
141SMC3_22415368_ChIP-Seq_MEFs_Mouse0.89257910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.57608053
2MP0008057_abnormal_DNA_replication3.18787214
3MP0009278_abnormal_bone_marrow3.02190373
4MP0010352_gastrointestinal_tract_polyps2.77910857
5MP0005275_abnormal_skin_tensile2.76694155
6MP0008438_abnormal_cutaneous_collagen2.71576100
7MP0005076_abnormal_cell_differentiation2.44801141
8MP0005257_abnormal_intraocular_pressure2.36408110
9MP0003941_abnormal_skin_development2.27000158
10MP0003566_abnormal_cell_adhesion2.21204325
11MP0005171_absent_coat_pigmentation2.16852995
12MP0004233_abnormal_muscle_weight2.16112383
13MP0003453_abnormal_keratinocyte_physiol2.13470326
14MP0000579_abnormal_nail_morphology2.12109516
15MP0002254_reproductive_system_inflammat2.06148387
16MP0003283_abnormal_digestive_organ1.97371633
17MP0009053_abnormal_anal_canal1.94232771
18MP0002009_preneoplasia1.87851933
19* MP0002796_impaired_skin_barrier1.84002756
20* MP0002060_abnormal_skin_morphology1.82620108
21MP0004957_abnormal_blastocyst_morpholog1.75734169
22MP0000762_abnormal_tongue_morphology1.72176129
23MP0005023_abnormal_wound_healing1.70802115
24MP0009384_cardiac_valve_regurgitation1.69687075
25MP0003119_abnormal_digestive_system1.68804242
26MP0004197_abnormal_fetal_growth/weight/1.67792315
27* MP0010030_abnormal_orbit_morphology1.63519691
28MP0002084_abnormal_developmental_patter1.62203209
29MP0002086_abnormal_extraembryonic_tissu1.56594150
30MP0004381_abnormal_hair_follicle1.52773053
31MP0004133_heterotaxia1.52475876
32MP0002653_abnormal_ependyma_morphology1.51961860
33MP0002085_abnormal_embryonic_tissue1.50118079
34MP0010094_abnormal_chromosome_stability1.50001776
35MP0005623_abnormal_meninges_morphology1.49158252
36MP0003111_abnormal_nucleus_morphology1.47197937
37MP0004947_skin_inflammation1.45975489
38MP0004858_abnormal_nervous_system1.45474030
39MP0000377_abnormal_hair_follicle1.41789950
40MP0002111_abnormal_tail_morphology1.41693316
41MP0005397_hematopoietic_system_phenotyp1.41200144
42MP0001545_abnormal_hematopoietic_system1.41200144
43* MP0005501_abnormal_skin_physiology1.38732162
44MP0001697_abnormal_embryo_size1.38622463
45MP0000516_abnormal_urinary_system1.37652167
46MP0005367_renal/urinary_system_phenotyp1.37652167
47MP0003567_abnormal_fetal_cardiomyocyte1.37437010
48MP0003755_abnormal_palate_morphology1.36448258
49MP0005409_darkened_coat_color1.35341633
50MP0003786_premature_aging1.35000308
51MP0001293_anophthalmia1.34906347
52MP0000467_abnormal_esophagus_morphology1.33643266
53MP0001542_abnormal_bone_strength1.32680572
54MP0001849_ear_inflammation1.31598666
55MP0003385_abnormal_body_wall1.31591290
56MP0002877_abnormal_melanocyte_morpholog1.30487314
57MP0001672_abnormal_embryogenesis/_devel1.29790847
58MP0005380_embryogenesis_phenotype1.29790847
59MP0008260_abnormal_autophagy1.29133274
60MP0003890_abnormal_embryonic-extraembry1.27658791
61MP0000350_abnormal_cell_proliferation1.27428563
62MP0005503_abnormal_tendon_morphology1.27307870
63* MP0005508_abnormal_skeleton_morphology1.26875163
64MP0003279_aneurysm1.25681109
65MP0000858_altered_metastatic_potential1.22344918
66* MP0009931_abnormal_skin_appearance1.21046602
67MP0003935_abnormal_craniofacial_develop1.20189815
68MP0000432_abnormal_head_morphology1.17430877
69MP0008932_abnormal_embryonic_tissue1.17294786
70MP0001730_embryonic_growth_arrest1.17174742
71MP0004185_abnormal_adipocyte_glucose1.16708577
72MP0003191_abnormal_cellular_cholesterol1.15677030
73MP0000767_abnormal_smooth_muscle1.15493177
74MP0000733_abnormal_muscle_development1.15180382
75MP0000751_myopathy1.14336084
76* MP0002282_abnormal_trachea_morphology1.09624824
77MP0010234_abnormal_vibrissa_follicle1.09390745
78MP0003828_pulmonary_edema1.09155676
79MP0001348_abnormal_lacrimal_gland1.08912827
80* MP0002249_abnormal_larynx_morphology1.08576649
81MP0003984_embryonic_growth_retardation1.08104090
82MP0003077_abnormal_cell_cycle1.07996681
83MP0003693_abnormal_embryo_hatching1.07632952
84MP0004272_abnormal_basement_membrane1.07173528
85MP0008995_early_reproductive_senescence1.07144661
86MP0002088_abnormal_embryonic_growth/wei1.06741183
87MP0010678_abnormal_skin_adnexa1.04887489
88MP0000537_abnormal_urethra_morphology1.04469793
89MP0009780_abnormal_chondrocyte_physiolo1.04383018
90MP0000462_abnormal_digestive_system1.04161404
91MP0000049_abnormal_middle_ear1.01619523
92MP0010368_abnormal_lymphatic_system0.99690554
93* MP0002932_abnormal_joint_morphology0.99076283
94MP0002080_prenatal_lethality0.97864087
95MP0010307_abnormal_tumor_latency0.97553053
96MP0000678_abnormal_parathyroid_gland0.97413082
97MP0005058_abnormal_lysosome_morphology0.97093257
98MP0000470_abnormal_stomach_morphology0.93874863
99* MP0005390_skeleton_phenotype0.92934176
100MP0002108_abnormal_muscle_morphology0.92852594
101MP0000566_synostosis0.92731854
102MP0000490_abnormal_crypts_of0.92461908
103* MP0001340_abnormal_eyelid_morphology0.92377008
104MP0002896_abnormal_bone_mineralization0.92297703
105MP0005451_abnormal_body_composition0.92225152
106MP0002098_abnormal_vibrissa_morphology0.91774526
107MP0000003_abnormal_adipose_tissue0.91192647
108* MP0002116_abnormal_craniofacial_bone0.91125332
109MP0003115_abnormal_respiratory_system0.90909932
110MP0002925_abnormal_cardiovascular_devel0.90839421
111MP0000428_abnormal_craniofacial_morphol0.89777928
112MP0003942_abnormal_urinary_system0.89085952
113MP0003045_fibrosis0.88891332
114MP0000534_abnormal_ureter_morphology0.88870005
115* MP0001216_abnormal_epidermal_layer0.87422015
116MP0002269_muscular_atrophy0.87359407
117MP0001243_abnormal_dermal_layer0.86839871
118MP0002697_abnormal_eye_size0.86194442
119MP0009250_abnormal_appendicular_skeleto0.86047745
120MP0000371_diluted_coat_color0.85376512
121* MP0002114_abnormal_axial_skeleton0.85300542
122MP0002933_joint_inflammation0.83239790
123MP0006054_spinal_hemorrhage0.82817675
124MP0000627_abnormal_mammary_gland0.82242082
125MP0001299_abnormal_eye_distance/0.81799771
126MP0000383_abnormal_hair_follicle0.81618060
127MP0002089_abnormal_postnatal_growth/wei0.81556409
128MP0010630_abnormal_cardiac_muscle0.80805264
129* MP0010771_integument_phenotype0.80098052
130MP0003091_abnormal_cell_migration0.79115042
131MP0003448_altered_tumor_morphology0.78128503
132MP0001958_emphysema0.77536006
133MP0002092_abnormal_eye_morphology0.76903317
134MP0000750_abnormal_muscle_regeneration0.76524225
135MP0004264_abnormal_extraembryonic_tissu0.75499289
136MP0002295_abnormal_pulmonary_circulatio0.75335363
137MP0003937_abnormal_limbs/digits/tail_de0.75329499
138MP0000367_abnormal_coat/_hair0.73064423
139MP0009379_abnormal_foot_pigmentation0.71416303
140MP0001533_abnormal_skeleton_physiology0.69456780
141MP0002998_abnormal_bone_remodeling0.65505624
142MP0005621_abnormal_cell_physiology0.65147169
143MP0005375_adipose_tissue_phenotype0.64321014
144MP0000759_abnormal_skeletal_muscle0.63947103
145MP0009672_abnormal_birth_weight0.61863485
146MP0001851_eye_inflammation0.61202469
147MP0003300_gastrointestinal_ulcer0.61098383
148* MP0002113_abnormal_skeleton_development0.59862542
149MP0006138_congestive_heart_failure0.59551485
150MP0001614_abnormal_blood_vessel0.59059258
151MP0004782_abnormal_surfactant_physiolog0.57879387

Predicted human phenotypes

RankGene SetZ-score
1Alopecia of scalp (HP:0002293)4.18891251
2Ulnar bowing (HP:0003031)4.07427596
3Rib fusion (HP:0000902)3.82398668
4Concave nail (HP:0001598)3.81615992
5Protrusio acetabuli (HP:0003179)3.74459678
6Abnormality of nail color (HP:0100643)3.56477728
7Turricephaly (HP:0000262)3.52334534
8Hypotrichosis (HP:0001006)3.48201127
9Cerebral aneurysm (HP:0004944)3.39713526
10Premature rupture of membranes (HP:0001788)3.39003837
11Coronal craniosynostosis (HP:0004440)3.30705789
12Selective tooth agenesis (HP:0001592)3.24176731
13Short humerus (HP:0005792)3.23709393
14Aplasia/hypoplasia of the humerus (HP:0006507)3.10281274
15Pustule (HP:0200039)3.08668834
16Annular pancreas (HP:0001734)3.08073424
17Vascular tortuosity (HP:0004948)3.04718794
18Bladder diverticulum (HP:0000015)3.02392614
19Facial hemangioma (HP:0000329)3.01598188
20Aortic dissection (HP:0002647)3.00533878
21Vertebral compression fractures (HP:0002953)2.97308507
22Vertebral hypoplasia (HP:0008417)2.88451933
23Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.88451933
24Aortic aneurysm (HP:0004942)2.87906241
25Natal tooth (HP:0000695)2.84157014
26Right ventricular cardiomyopathy (HP:0011663)2.83929688
27Onycholysis (HP:0001806)2.76921354
28Broad metatarsal (HP:0001783)2.76117571
29Fragile nails (HP:0001808)2.74409554
30Arterial tortuosity (HP:0005116)2.73843750
31Ankle contracture (HP:0006466)2.73239465
32Follicular hyperkeratosis (HP:0007502)2.72790448
33Thick nail (HP:0001805)2.71934400
34Rectovaginal fistula (HP:0000143)2.71817505
35Rectal fistula (HP:0100590)2.71817505
36Osteolytic defects of the hand bones (HP:0009699)2.70845167
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.70845167
38Abnormal hemoglobin (HP:0011902)2.70240420
39Shallow orbits (HP:0000586)2.69590685
40Atrophic scars (HP:0001075)2.66370099
41Distal lower limb muscle weakness (HP:0009053)2.66006855
42Bowed forearm bones (HP:0003956)2.64005810
43Bowing of the arm (HP:0006488)2.64005810
44Pili torti (HP:0003777)2.63550571
45Hyperacusis (HP:0010780)2.63106575
46Short nail (HP:0001799)2.56869959
47Wormian bones (HP:0002645)2.56732538
48Absent radius (HP:0003974)2.53992645
49Milia (HP:0001056)2.52886466
50Congenital hip dislocation (HP:0001374)2.52835910
51Biconcave vertebral bodies (HP:0004586)2.52390694
52Dilatation of the ascending aorta (HP:0005111)2.51989859
53Mildly elevated creatine phosphokinase (HP:0008180)2.51965198
54Intestinal fistula (HP:0100819)2.49449817
55Increased connective tissue (HP:0009025)2.47567608
56Advanced eruption of teeth (HP:0006288)2.45658461
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.45100512
58Vaginal fistula (HP:0004320)2.43652867
59Abnormality of dentin (HP:0010299)2.42617926
60Aplasia involving forearm bones (HP:0009822)2.35740372
61Absent forearm bone (HP:0003953)2.35740372
62Poikiloderma (HP:0001029)2.35492265
63Genu recurvatum (HP:0002816)2.34415528
64Basal cell carcinoma (HP:0002671)2.34293714
65Hypoplastic ischia (HP:0003175)2.31780976
66Soft skin (HP:0000977)2.31535138
67Vertebral fusion (HP:0002948)2.29716180
68Squamous cell carcinoma (HP:0002860)2.28579995
69Thin bony cortex (HP:0002753)2.28478119
70Spinal cord lesions (HP:0100561)2.26000284
71Syringomyelia (HP:0003396)2.26000284
72Mitral regurgitation (HP:0001653)2.24929396
73Distal lower limb amyotrophy (HP:0008944)2.22494441
74Trismus (HP:0000211)2.20723122
75Premature skin wrinkling (HP:0100678)2.19474501
76Achilles tendon contracture (HP:0001771)2.18948180
77Spondylolisthesis (HP:0003302)2.16196893
78Plantar hyperkeratosis (HP:0007556)2.15801900
79Increased IgE level (HP:0003212)2.15437494
80Type 1 muscle fiber predominance (HP:0003803)2.14333120
81Broad face (HP:0000283)2.12457404
82Nail dystrophy (HP:0008404)2.10268898
83Choanal stenosis (HP:0000452)2.09932718
84Abnormality of the aortic arch (HP:0012303)2.08918777
85Ridged nail (HP:0001807)2.08862877
86Joint laxity (HP:0001388)2.08655062
87Abnormal hair laboratory examination (HP:0003328)2.07430675
88Palmoplantar hyperkeratosis (HP:0000972)2.07014100
89Fragile skin (HP:0001030)2.06601953
90Pterygium (HP:0001059)2.05075625
91Short 5th finger (HP:0009237)2.04650102
92Orthostatic hypotension (HP:0001278)2.03252545
93Palmar hyperkeratosis (HP:0010765)2.02690343
94Increased variability in muscle fiber diameter (HP:0003557)2.02665457
95Joint stiffness (HP:0001387)2.02346483
96Distal upper limb amyotrophy (HP:0007149)2.01665484
97Upper limb amyotrophy (HP:0009129)2.01665484
98Mitral valve prolapse (HP:0001634)2.01494067
99Abnormality of the ischium (HP:0003174)1.99186632
100Broad thumb (HP:0011304)1.99056099
101Lip pit (HP:0100267)1.97465605
102Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97125497
103Congenital ichthyosiform erythroderma (HP:0007431)1.96983865
104Neoplasm of the oral cavity (HP:0100649)1.96539587
105Aortic regurgitation (HP:0001659)1.95303520
106Muscle fibrillation (HP:0010546)1.95028863
107Short chin (HP:0000331)1.94926521
108Abnormality of the astrocytes (HP:0100707)1.93651271
109Astrocytoma (HP:0009592)1.93651271
110Absent thumb (HP:0009777)1.92240349
111Generalized amyotrophy (HP:0003700)1.91920998
112Bowel diverticulosis (HP:0005222)1.91649073
113Abnormality of the labia minora (HP:0012880)1.91257288
114Absent eyelashes (HP:0000561)1.90843338
115Elbow flexion contracture (HP:0002987)1.90047050
116Absent frontal sinuses (HP:0002688)1.89930346
117Hamartoma (HP:0010566)1.88161264
118Slender build (HP:0001533)1.88026288
119Esophageal atresia (HP:0002032)1.87738208
120Spinal rigidity (HP:0003306)1.86645622
121Obstructive sleep apnea (HP:0002870)1.85689878
122Long palpebral fissure (HP:0000637)1.85684445
123Sparse lateral eyebrow (HP:0005338)1.85401663
124Broad hallux (HP:0010055)1.85007973
125Patellar aplasia (HP:0006443)1.84495857
126Cervical subluxation (HP:0003308)1.84215531
127Abnormality of skeletal muscle fiber size (HP:0012084)1.84073137
128Alacrima (HP:0000522)1.83889632
129Abnormality of the Achilles tendon (HP:0005109)1.83656745
130Short phalanx of the thumb (HP:0009660)1.83641378
131Aneurysm (HP:0002617)1.83322972
132Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83171065
133Short 4th metacarpal (HP:0010044)1.83171065
134Blue sclerae (HP:0000592)1.83088522
135Erythema (HP:0010783)1.81843019
136Carpal synostosis (HP:0009702)1.81546410
137Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81169605
138Tongue fasciculations (HP:0001308)1.80576967
139Thin ribs (HP:0000883)1.80150351
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.80036875
141Short 1st metacarpal (HP:0010034)1.80036875
142Aplasia/Hypoplasia of the patella (HP:0006498)1.78980540
143Gastrointestinal atresia (HP:0002589)1.78963696
144Neonatal short-limb short stature (HP:0008921)1.78559340
145Missing ribs (HP:0000921)1.78479223
146Ependymoma (HP:0002888)1.77823181
147Deviation of the hallux (HP:0010051)1.77715285
148Spinal cord compression (HP:0002176)1.77449010
149Acanthosis nigricans (HP:0000956)1.77415515
150Abnormal blistering of the skin (HP:0008066)1.77379282
151Broad toe (HP:0001837)1.77312055
152Disproportionate tall stature (HP:0001519)1.76525045
153Abnormality of the salivary glands (HP:0010286)1.76505401
154Male infertility (HP:0003251)1.76393254
155Abnormality of the calcaneus (HP:0008364)1.76376482
156Difficulty climbing stairs (HP:0003551)1.75886994
157Increased IgM level (HP:0003496)1.75267120
158Abnormality of the umbilical cord (HP:0010881)1.74700373
159Abnormality of the distal phalanges of the toes (HP:0010182)1.74331004
160Hyperextensible skin (HP:0000974)1.74188651
161Round ear (HP:0100830)1.73857237
162Intestinal atresia (HP:0011100)1.73318356
163Abnormality of the acetabulum (HP:0003170)1.73283575
164Hallux valgus (HP:0001822)1.73058612
165Abnormality of oral frenula (HP:0000190)1.72489121
166Narrow nasal bridge (HP:0000446)1.70894480
167Metaphyseal cupping (HP:0003021)1.70610847
168Woolly hair (HP:0002224)1.70468271
169Delayed cranial suture closure (HP:0000270)1.69485259
170Sparse eyelashes (HP:0000653)1.68870178
171Vertebral clefting (HP:0008428)1.68358636
172Split hand (HP:0001171)1.68004047
173Anteriorly placed anus (HP:0001545)1.67084094

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.35702185
2ICK4.75097263
3SMG13.59641813
4MAPK153.23411004
5MAP3K63.02809951
6PDGFRA2.66872577
7BMX2.62541614
8MAP3K112.58942055
9EPHA22.43267562
10LATS22.40882188
11TYRO32.28221737
12MATK2.11421176
13IRAK32.11076984
14FGR2.10353391
15NME22.02022572
16TRIB32.01302176
17CDK121.93649037
18TESK11.93338631
19PRKD21.86079809
20TRPM71.77045216
21LATS11.75477955
22PRPF4B1.73754054
23PINK11.73162370
24PIM21.65747448
25EPHB11.64529728
26MYLK1.61764431
27TTN1.59327198
28CSK1.58042321
29RPS6KB21.53945161
30CDK61.53663457
31RIPK11.51791607
32DYRK1B1.50465783
33FGFR41.40745438
34MAP3K101.37910526
35AKT31.32658987
36DAPK11.27281300
37NTRK11.26971766
38PIM11.26403219
39MAPKAPK31.21590741
40MTOR1.20026483
41VRK21.12148935
42EEF2K1.11784195
43UHMK11.11692350
44PKN21.08787853
45RPS6KL11.08680233
46RPS6KC11.08680233
47YES11.06359207
48MAP2K21.04241659
49GSK3A0.96948526
50* CDK70.95703621
51STK30.95338337
52RPS6KA60.95013312
53LMTK20.93940413
54GRK60.93147714
55RPS6KA20.92581025
56NEK20.92283482
57CDC42BPA0.91497190
58DYRK30.91475022
59MET0.91045380
60PAK40.90707651
61PTK20.87583420
62MAP3K30.86639095
63SIK10.85257946
64PLK10.84714859
65CHEK20.84227874
66EPHB20.82917539
67PAK20.80620102
68ARAF0.79693818
69FGFR10.79224863
70STK38L0.78703946
71MAPK110.77472965
72SCYL20.75466586
73STK100.72896686
74TBK10.72309427
75ERN10.72170051
76MAP2K30.71994927
77PRKD30.71262456
78TESK20.70790565
79MELK0.69695109
80RPS6KA10.69688800
81LIMK10.68637623
82PDGFRB0.66191565
83SIK30.65645305
84ZAP700.64549348
85WEE10.64076889
86TAF10.63372397
87NEK10.61680946
88MARK20.61345443
89FLT30.60083175
90MAPK70.59836343
91CDK40.58992263
92TAOK20.58933442
93ALK0.57939704
94TTK0.56125398
95MAP3K90.55915134
96PRKG20.55169723
97MUSK0.54593443
98BUB10.52981755
99CDK80.52940644
100LRRK20.52896596
101RPS6KA40.52496225
102PHKG10.52269757
103PHKG20.52269757
104FER0.51932553
105CDK20.51418785
106AURKB0.50869415
107ATR0.50438399
108MAPK10.49719054
109PTK60.48185347
110MAP3K80.47877986
111KSR20.46234753
112ERBB40.46141212
113MAP3K10.46043112
114CDK90.45099932
115TAOK10.44051472
116ERBB30.43187091
117DMPK0.42165359
118CHEK10.41700531
119MAPKAPK20.41045954
120PRKCI0.40970406
121AURKA0.39671899
122HIPK20.39570265
123MAP3K20.39216300
124NEK90.38983432
125ROCK20.38931085
126MAP2K10.38800580
127MAP3K130.38713524
128JAK30.38691463
129PRKAA10.37464631
130ABL20.37435287
131EGFR0.35709328
132CDC70.35572744
133PRKD10.35248852
134ATM0.34673642
135IRAK20.34516256
136PDPK10.34370604
137MAP3K140.33896522
138PAK10.32326827
139ILK0.32019020
140MST1R0.31787191
141INSR0.30585128
142CSNK2A10.29533262
143STK380.28738619
144TGFBR10.27292542
145CHUK0.26565455

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.59428975
2Fatty acid biosynthesis_Homo sapiens_hsa000613.47602156
3Base excision repair_Homo sapiens_hsa034103.04176680
4DNA replication_Homo sapiens_hsa030302.63631850
5Hippo signaling pathway_Homo sapiens_hsa043902.58727043
6Hedgehog signaling pathway_Homo sapiens_hsa043402.54640966
7Basal cell carcinoma_Homo sapiens_hsa052172.50825602
8Adherens junction_Homo sapiens_hsa045202.48081577
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22029667
10Notch signaling pathway_Homo sapiens_hsa043302.21665542
11p53 signaling pathway_Homo sapiens_hsa041152.10309108
12RNA transport_Homo sapiens_hsa030132.07460342
13Bladder cancer_Homo sapiens_hsa052191.95536252
14TGF-beta signaling pathway_Homo sapiens_hsa043501.93346098
15mTOR signaling pathway_Homo sapiens_hsa041501.92876113
16Spliceosome_Homo sapiens_hsa030401.91838050
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83122414
18Nucleotide excision repair_Homo sapiens_hsa034201.71341293
19ECM-receptor interaction_Homo sapiens_hsa045121.69903827
20mRNA surveillance pathway_Homo sapiens_hsa030151.66308205
21MicroRNAs in cancer_Homo sapiens_hsa052061.60068788
22Cell cycle_Homo sapiens_hsa041101.59793890
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58432731
24Focal adhesion_Homo sapiens_hsa045101.49604579
25Proteoglycans in cancer_Homo sapiens_hsa052051.48964922
26Small cell lung cancer_Homo sapiens_hsa052221.48305412
27Ribosome_Homo sapiens_hsa030101.47105077
28Wnt signaling pathway_Homo sapiens_hsa043101.39740242
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37069590
30Non-small cell lung cancer_Homo sapiens_hsa052231.36567293
31Pentose phosphate pathway_Homo sapiens_hsa000301.35604104
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.35252264
33Other glycan degradation_Homo sapiens_hsa005111.31387871
34Tight junction_Homo sapiens_hsa045301.26454495
35Longevity regulating pathway - mammal_Homo sapiens_hsa042111.23729307
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21318265
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20273816
38Glioma_Homo sapiens_hsa052141.19061534
39Chronic myeloid leukemia_Homo sapiens_hsa052201.16784011
40One carbon pool by folate_Homo sapiens_hsa006701.16594798
41Renal cell carcinoma_Homo sapiens_hsa052111.13323637
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.12042222
43Homologous recombination_Homo sapiens_hsa034401.11427296
44VEGF signaling pathway_Homo sapiens_hsa043701.07981252
45Fanconi anemia pathway_Homo sapiens_hsa034601.07025611
46Lysine degradation_Homo sapiens_hsa003101.06696077
47Hepatitis C_Homo sapiens_hsa051601.06092949
48Shigellosis_Homo sapiens_hsa051311.05220134
49Colorectal cancer_Homo sapiens_hsa052101.05156031
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04998309
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03900806
52Biosynthesis of amino acids_Homo sapiens_hsa012301.01861472
53Arginine and proline metabolism_Homo sapiens_hsa003301.01615852
54Circadian rhythm_Homo sapiens_hsa047101.01082509
55Thyroid cancer_Homo sapiens_hsa052160.99740963
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.99043082
57Viral carcinogenesis_Homo sapiens_hsa052030.96859720
58Galactose metabolism_Homo sapiens_hsa000520.96770561
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94699971
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.94589107
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.93912200
62HTLV-I infection_Homo sapiens_hsa051660.93241320
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92075072
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91993583
65Pathways in cancer_Homo sapiens_hsa052000.91003994
66Axon guidance_Homo sapiens_hsa043600.90873810
67Dilated cardiomyopathy_Homo sapiens_hsa054140.90810982
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90488534
69Viral myocarditis_Homo sapiens_hsa054160.90463865
70Acute myeloid leukemia_Homo sapiens_hsa052210.90433902
71GnRH signaling pathway_Homo sapiens_hsa049120.85460867
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85045730
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.84183066
74Sulfur relay system_Homo sapiens_hsa041220.81546662
75N-Glycan biosynthesis_Homo sapiens_hsa005100.81297041
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81047386
77Amoebiasis_Homo sapiens_hsa051460.80314647
78TNF signaling pathway_Homo sapiens_hsa046680.77970191
79Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77937257
80Prostate cancer_Homo sapiens_hsa052150.74879829
81Malaria_Homo sapiens_hsa051440.74000111
82Prion diseases_Homo sapiens_hsa050200.73033360
83Inositol phosphate metabolism_Homo sapiens_hsa005620.72365037
84Toxoplasmosis_Homo sapiens_hsa051450.72129742
85Endometrial cancer_Homo sapiens_hsa052130.70167045
86Oocyte meiosis_Homo sapiens_hsa041140.70014846
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.69776192
88Protein digestion and absorption_Homo sapiens_hsa049740.69465561
89Dorso-ventral axis formation_Homo sapiens_hsa043200.69327946
90Melanoma_Homo sapiens_hsa052180.68247095
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65102491
92Folate biosynthesis_Homo sapiens_hsa007900.65087640
93Platelet activation_Homo sapiens_hsa046110.64949720
94Insulin resistance_Homo sapiens_hsa049310.62134925
95AMPK signaling pathway_Homo sapiens_hsa041520.61274441
96Sphingolipid metabolism_Homo sapiens_hsa006000.61033967
97Lysosome_Homo sapiens_hsa041420.60104295
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58387180
99Rap1 signaling pathway_Homo sapiens_hsa040150.58276203
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.56651052
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.56388504
102Legionellosis_Homo sapiens_hsa051340.55718110
103Prolactin signaling pathway_Homo sapiens_hsa049170.55596210
104Vibrio cholerae infection_Homo sapiens_hsa051100.54343066
105Insulin signaling pathway_Homo sapiens_hsa049100.54308788
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53629356
107Salmonella infection_Homo sapiens_hsa051320.52888850
108HIF-1 signaling pathway_Homo sapiens_hsa040660.52854090
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51846712
110Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51183317
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50618815
112Apoptosis_Homo sapiens_hsa042100.48265012
113Gap junction_Homo sapiens_hsa045400.47924235
114Epstein-Barr virus infection_Homo sapiens_hsa051690.47863507
115Pancreatic cancer_Homo sapiens_hsa052120.47607656
116T cell receptor signaling pathway_Homo sapiens_hsa046600.47578050
117Melanogenesis_Homo sapiens_hsa049160.46966304
118Hepatitis B_Homo sapiens_hsa051610.46388031
119Herpes simplex infection_Homo sapiens_hsa051680.44137651
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.44084253
121RNA degradation_Homo sapiens_hsa030180.42859748
122Fructose and mannose metabolism_Homo sapiens_hsa000510.42746270
123ErbB signaling pathway_Homo sapiens_hsa040120.41610497
124Choline metabolism in cancer_Homo sapiens_hsa052310.40485679
125Estrogen signaling pathway_Homo sapiens_hsa049150.37481260
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36245252
127Fatty acid metabolism_Homo sapiens_hsa012120.35789565
128MAPK signaling pathway_Homo sapiens_hsa040100.35656746
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.34862933
130Endocytosis_Homo sapiens_hsa041440.30993903
131Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30204615
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29310588
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.29254884
134RNA polymerase_Homo sapiens_hsa030200.28840064
135FoxO signaling pathway_Homo sapiens_hsa040680.26331359
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.23793096

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