RARB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prepulse inhibition (GO:0060134)6.55881809
2synaptic transmission, dopaminergic (GO:0001963)6.38747074
3adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.82470358
4nucleoside transmembrane transport (GO:1901642)5.51124939
5regulation of synapse structural plasticity (GO:0051823)5.42842247
6negative regulation of cytosolic calcium ion concentration (GO:0051481)5.15820169
7regulation of dopamine uptake involved in synaptic transmission (GO:0051584)4.91343681
8regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)4.91343681
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.86244435
10neuron projection extension involved in neuron projection guidance (GO:1902284)4.82393368
11axon extension involved in axon guidance (GO:0048846)4.82393368
12response to amphetamine (GO:0001975)4.56069412
13* striatum development (GO:0021756)4.51272161
14behavioral response to cocaine (GO:0048148)4.48205214
15auditory behavior (GO:0031223)4.46594514
16dopamine receptor signaling pathway (GO:0007212)4.41096551
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.34022557
18adenosine receptor signaling pathway (GO:0001973)4.32957945
19peristalsis (GO:0030432)4.13998976
20regulation of long-term neuronal synaptic plasticity (GO:0048169)4.12556628
21regulation of neurotransmitter uptake (GO:0051580)4.12181096
22neurotransmitter-gated ion channel clustering (GO:0072578)4.09445424
23positive regulation of renal sodium excretion (GO:0035815)4.03134270
24regulation of cardioblast differentiation (GO:0051890)4.01841490
25cAMP catabolic process (GO:0006198)4.01807895
26locomotory exploration behavior (GO:0035641)4.00324818
27negative regulation of dendrite development (GO:2000171)3.97924520
28regulation of female receptivity (GO:0045924)3.92264722
29response to caffeine (GO:0031000)3.90875050
30positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.87960013
31regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87609687
32lymphangiogenesis (GO:0001946)3.87037956
33positive regulation of synaptic transmission, GABAergic (GO:0032230)3.84326619
34synaptic vesicle maturation (GO:0016188)3.82515720
35glomerular filtration (GO:0003094)3.80639588
36nucleoside transport (GO:0015858)3.78455006
37drinking behavior (GO:0042756)3.76101414
38substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.73419836
39substrate-independent telencephalic tangential migration (GO:0021826)3.73419836
40regulation of chemokine-mediated signaling pathway (GO:0070099)3.72612982
41regulation of dendritic spine morphogenesis (GO:0061001)3.68236545
42regulation of glutamate receptor signaling pathway (GO:1900449)3.67994784
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.67170376
44negative regulation of sodium ion transport (GO:0010766)3.66883164
45regulation of neuronal synaptic plasticity (GO:0048168)3.63872635
46response to auditory stimulus (GO:0010996)3.63211149
47renal filtration (GO:0097205)3.60041576
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.59897671
49cardiac muscle cell proliferation (GO:0060038)3.50326236
50regulation of transforming growth factor beta2 production (GO:0032909)3.50231362
51neuromuscular process controlling balance (GO:0050885)3.49535708
52regulation of glutamate secretion (GO:0014048)3.49409305
53glomerular basement membrane development (GO:0032836)3.48606949
54neuronal ion channel clustering (GO:0045161)3.46376773
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.45997853
56negative regulation of vascular permeability (GO:0043116)3.38861575
57cyclic nucleotide catabolic process (GO:0009214)3.36846952
58female mating behavior (GO:0060180)3.36616126
59platelet dense granule organization (GO:0060155)3.36224655
60cAMP metabolic process (GO:0046058)3.35544651
61neuron-neuron synaptic transmission (GO:0007270)3.31845434
62regulation of membrane repolarization (GO:0060306)3.31582839
63vocalization behavior (GO:0071625)3.31504577
64activation of protein kinase A activity (GO:0034199)3.30442669
65response to histamine (GO:0034776)3.30376325
66cilium or flagellum-dependent cell motility (GO:0001539)3.30294865
67regulation of norepinephrine secretion (GO:0014061)3.28493520
68phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.27274593
69visual learning (GO:0008542)3.25696515
70response to amine (GO:0014075)3.24644349
71behavioral defense response (GO:0002209)3.24191340
72behavioral fear response (GO:0001662)3.24191340
73negative chemotaxis (GO:0050919)3.22341430
74cGMP metabolic process (GO:0046068)3.20857043
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.19951417
76positive regulation of action potential (GO:0045760)3.19805251
77neurotransmitter secretion (GO:0007269)3.17731151
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.17669655
79striated muscle cell proliferation (GO:0014855)3.16982075
80establishment of nucleus localization (GO:0040023)3.15109240
81transmission of nerve impulse (GO:0019226)3.14353946
82positive regulation of neurotransmitter transport (GO:0051590)3.14277191
83regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.14073236
84pericardium development (GO:0060039)3.13497186
85regulation of synaptic transmission, dopaminergic (GO:0032225)3.10535470
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09757584
87positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.07868063
88cilium movement (GO:0003341)3.06987637
89cAMP biosynthetic process (GO:0006171)3.06578876
90relaxation of cardiac muscle (GO:0055119)3.06237261
91embryonic foregut morphogenesis (GO:0048617)3.06132206
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05035189
93neural crest cell development (GO:0014032)3.04868729
94regulation of excitatory postsynaptic membrane potential (GO:0060079)3.02744396
95visual behavior (GO:0007632)3.01968842
96embryonic viscerocranium morphogenesis (GO:0048703)3.00966786
97dendritic spine morphogenesis (GO:0060997)2.98261762
98cardiac conduction (GO:0061337)2.97899669
99regulation of synaptic transmission, glutamatergic (GO:0051966)2.97385569
100negative regulation of axon guidance (GO:1902668)2.96189812
101nucleus localization (GO:0051647)2.96115791
102regulation of heart morphogenesis (GO:2000826)2.95672824
103synaptic vesicle docking involved in exocytosis (GO:0016081)2.94221963
104regulation of voltage-gated calcium channel activity (GO:1901385)2.93334078
105negative regulation of hormone biosynthetic process (GO:0032353)2.93035884
106neuron remodeling (GO:0016322)2.92818657
107layer formation in cerebral cortex (GO:0021819)2.92092391
108regulation of axon guidance (GO:1902667)2.91740391
109ionotropic glutamate receptor signaling pathway (GO:0035235)2.91703706
110muscle cell proliferation (GO:0033002)2.91086477
111mechanosensory behavior (GO:0007638)2.89480339
112axonemal dynein complex assembly (GO:0070286)2.88667583
113cell communication by electrical coupling (GO:0010644)2.86777922
114synapsis (GO:0007129)2.85170478
115synaptic transmission, glutamatergic (GO:0035249)2.84822095
116multicellular organismal signaling (GO:0035637)2.84788309
117positive regulation of urine volume (GO:0035810)2.82611145
118long-term memory (GO:0007616)2.81704450
119retinal ganglion cell axon guidance (GO:0031290)2.81159631
120artery development (GO:0060840)2.80698700
121regulation of heart rate by cardiac conduction (GO:0086091)2.80653062
122embryonic heart tube development (GO:0035050)2.80584195
123cardiac muscle cell action potential involved in contraction (GO:0086002)2.79556337
124paraxial mesoderm development (GO:0048339)2.78751973
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.76823410
126epithelial cilium movement (GO:0003351)2.75453532
127positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.74970004
128regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74605463
129adult heart development (GO:0007512)2.74089218
130regulation of postsynaptic membrane potential (GO:0060078)2.74073093
131collagen fibril organization (GO:0030199)2.74023768
132cardiac muscle cell action potential (GO:0086001)2.73731849
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72793631
134regulation of circadian sleep/wake cycle (GO:0042749)2.72666974
135regulation of circadian sleep/wake cycle, sleep (GO:0045187)2.72666974
136interkinetic nuclear migration (GO:0022027)2.71502256
137fear response (GO:0042596)2.71163405
138cell communication involved in cardiac conduction (GO:0086065)2.71001136
139cardiac myofibril assembly (GO:0055003)2.70535270
140exploration behavior (GO:0035640)2.70288619
141synaptic vesicle exocytosis (GO:0016079)2.70102509
142G-protein coupled receptor internalization (GO:0002031)2.69076126
143regulation of synaptic plasticity (GO:0048167)2.68434933
144regulation of dendritic spine development (GO:0060998)2.68184517
145vascular smooth muscle contraction (GO:0014829)2.67170361
146regulation of cardioblast proliferation (GO:0003264)2.65206607
147regulation of secondary heart field cardioblast proliferation (GO:0003266)2.65206607
148chondrocyte development (GO:0002063)2.62712292
149neuronal action potential (GO:0019228)2.58134926
150negative regulation of leukocyte chemotaxis (GO:0002689)2.57334663
151negative regulation of hormone metabolic process (GO:0032351)2.54745119
152negative regulation of cardiac muscle hypertrophy (GO:0010614)2.53997974
153mesenchymal cell development (GO:0014031)2.53702634
154organ growth (GO:0035265)2.51843674
155negative regulation of Rho protein signal transduction (GO:0035024)2.49247142
156thrombin receptor signaling pathway (GO:0070493)2.48328209
157innervation (GO:0060384)2.47267550
158positive regulation of heart contraction (GO:0045823)2.45705920
159endothelium development (GO:0003158)2.44474102
160regulation of hippo signaling (GO:0035330)2.43192462
161cell migration involved in heart development (GO:0060973)2.42004056
162regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.41056728
163negative regulation of muscle hypertrophy (GO:0014741)2.38316303
164bone trabecula formation (GO:0060346)2.36807431
165axoneme assembly (GO:0035082)2.34091718
166negative regulation of heart rate (GO:0010459)2.33712264
167cardiac muscle hypertrophy (GO:0003300)2.32099399
168chemosensory behavior (GO:0007635)2.31797926
169* negative regulation of chondrocyte differentiation (GO:0032331)2.31615257
170* outflow tract septum morphogenesis (GO:0003148)2.31486845
171otic vesicle formation (GO:0030916)2.31255768
172striated muscle hypertrophy (GO:0014897)2.30823841
173generation of neurons (GO:0048699)2.29979559
174negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.29935899
175myofibril assembly (GO:0030239)2.29712461
176regulation of cell maturation (GO:1903429)2.28032291
177axon extension (GO:0048675)2.26615824
178enteric nervous system development (GO:0048484)2.26143462
179SMAD protein complex assembly (GO:0007183)2.25695229
180cartilage condensation (GO:0001502)2.23865931
181cell aggregation (GO:0098743)2.23865931
182smooth muscle tissue development (GO:0048745)2.23848435
183keratan sulfate catabolic process (GO:0042340)2.22631545
184regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.22162128
185ventricular cardiac muscle cell development (GO:0055015)2.22132172
186intraciliary transport (GO:0042073)2.22102287
187positive regulation of cardiac muscle cell proliferation (GO:0060045)2.21829695
188left/right axis specification (GO:0070986)2.21659072
189positive regulation of heart rate (GO:0010460)2.21387565
190positive regulation of cardiac muscle tissue development (GO:0055025)2.20982633
191regulation of cardiac muscle hypertrophy (GO:0010611)2.19731944
192establishment of tissue polarity (GO:0007164)2.19224036
193establishment of planar polarity (GO:0001736)2.19224036
194chondrocyte proliferation (GO:0035988)2.19041530
195positive regulation of cardiac muscle tissue growth (GO:0055023)2.18143978
196regulation of sarcomere organization (GO:0060297)2.17992124
197glomerulus development (GO:0032835)2.16856631
198regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.16855810
199somite development (GO:0061053)2.16800946

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARB_27405468_Chip-Seq_BRAIN_Mouse3.39375362
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12200818
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95618858
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.84002250
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.84002250
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.74759011
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74508734
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.71219304
9EZH2_22144423_ChIP-Seq_EOC_Human2.64635770
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60725853
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.54555351
12GBX2_23144817_ChIP-Seq_PC3_Human2.54354961
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.38690437
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.36518950
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.35807023
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.29615787
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.29324976
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22566924
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.22350150
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21964498
21* DROSHA_22980978_ChIP-Seq_HELA_Human2.16703865
22RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.15271297
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.14393661
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.11350732
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07145663
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.06255015
27* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05755046
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04744611
29ERG_21242973_ChIP-ChIP_JURKAT_Human2.00645848
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98018411
31AR_21572438_ChIP-Seq_LNCaP_Human1.95659865
32FUS_26573619_Chip-Seq_HEK293_Human1.87255301
33ESR1_20079471_ChIP-ChIP_T-47D_Human1.82873182
34TP53_16413492_ChIP-PET_HCT116_Human1.75984948
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73909500
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71857263
37EP300_21415370_ChIP-Seq_HL-1_Mouse1.69141719
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68197137
39NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67883100
40NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67883100
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66916257
42REST_21632747_ChIP-Seq_MESCs_Mouse1.65400460
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.63734948
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61125839
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56833948
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56372486
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54542439
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52926641
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.52923995
50CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51957336
51WT1_25993318_ChIP-Seq_PODOCYTE_Human1.50838765
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.48761111
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47831165
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.44415722
55* RING1B_27294783_Chip-Seq_ESCs_Mouse1.44008730
56TAF15_26573619_Chip-Seq_HEK293_Human1.43462976
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.43052369
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42270919
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40998915
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40812876
61TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39894351
62* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36280771
63ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36051016
64EWS_26573619_Chip-Seq_HEK293_Human1.35731879
65RNF2_27304074_Chip-Seq_NSC_Mouse1.33931795
66CTNNB1_20460455_ChIP-Seq_HCT116_Human1.33226370
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33090598
68BCAT_22108803_ChIP-Seq_LS180_Human1.32910006
69TBX3_20139965_ChIP-Seq_ESCs_Mouse1.32541572
70TBX3_20139965_ChIP-Seq_MESCs_Mouse1.32407240
71* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31329434
72* CJUN_26792858_Chip-Seq_BT549_Human1.31253563
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30594283
74DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.30159560
75VDR_22108803_ChIP-Seq_LS180_Human1.29767375
76* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.29591064
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27991961
78SMAD4_21799915_ChIP-Seq_A2780_Human1.26868479
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26389295
80CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26289109
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26245130
82ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26125114
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25834660
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.25751227
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.25715282
86ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25481477
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.24674339
88* TCF4_23295773_ChIP-Seq_U87_Human1.23927384
89* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23356042
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.21729657
91* AR_19668381_ChIP-Seq_PC3_Human1.19420200
92* SMAD3_21741376_ChIP-Seq_EPCs_Human1.17750331
93AHR_22903824_ChIP-Seq_MCF-7_Human1.16221744
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15860309
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15317368
96PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14614803
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14228465
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.13864661
99TCF4_22108803_ChIP-Seq_LS180_Human1.13122889
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.12959276
101* SOX9_26525672_Chip-Seq_HEART_Mouse1.12064308
102KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11854035
103KDM2B_26808549_Chip-Seq_K562_Human1.11100908
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11068978
105SMAD_19615063_ChIP-ChIP_OVARY_Human1.10170528
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.10042931
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.08564154
108* P300_19829295_ChIP-Seq_ESCs_Human1.08330682
109CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08107684
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07544112
111TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06727625
112RXR_22108803_ChIP-Seq_LS180_Human1.06276135
113SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06159839
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.05088979
115* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04994888
116ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02112021
117EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02103237
118* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.01467922
119CTCF_27219007_Chip-Seq_Bcells_Human1.01029713
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.00646261
121ARNT_22903824_ChIP-Seq_MCF-7_Human1.00169925
122NR3C1_23031785_ChIP-Seq_PC12_Mouse0.99803174
123ZNF274_21170338_ChIP-Seq_K562_Hela0.99237275
124* ISL1_27105846_Chip-Seq_CPCs_Mouse0.98065422
125ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97835350
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.97444219
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97248940
128* AR_25329375_ChIP-Seq_VCAP_Human0.96116895
129* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95438773
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94755509
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93887255
132YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93841685
133KLF4_19829295_ChIP-Seq_ESCs_Human0.92969986
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92880050
135AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92209977
136TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91336512
137CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89891720
138TP53_18474530_ChIP-ChIP_U2OS_Human0.89444058
139* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88496774
140* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.87903062
141* STAT3_23295773_ChIP-Seq_U87_Human0.86892950
142* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86098342
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.84918180

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.93942614
2MP0004859_abnormal_synaptic_plasticity4.71612525
3MP0008438_abnormal_cutaneous_collagen3.23253105
4MP0005171_absent_coat_pigmentation3.01859677
5* MP0003635_abnormal_synaptic_transmissio2.93510449
6MP0009745_abnormal_behavioral_response2.87768632
7MP0005503_abnormal_tendon_morphology2.83033713
8* MP0002063_abnormal_learning/memory/cond2.65783881
9MP0003880_abnormal_central_pattern2.62882613
10MP0003136_yellow_coat_color2.60716499
11MP0002102_abnormal_ear_morphology2.49718200
12MP0005275_abnormal_skin_tensile2.32519425
13MP0001529_abnormal_vocalization2.26269011
14MP0005646_abnormal_pituitary_gland2.24778707
15MP0001486_abnormal_startle_reflex2.22137976
16MP0001879_abnormal_lymphatic_vessel2.15778453
17MP0004270_analgesia2.04422407
18MP0002909_abnormal_adrenal_gland1.90207517
19MP0002064_seizures1.88772745
20MP0002572_abnormal_emotion/affect_behav1.87672782
21MP0005167_abnormal_blood-brain_barrier1.85533963
22MP0009046_muscle_twitch1.85284581
23MP0001984_abnormal_olfaction1.84419527
24MP0005085_abnormal_gallbladder_physiolo1.78569403
25MP0010368_abnormal_lymphatic_system1.78276748
26MP0010234_abnormal_vibrissa_follicle1.75737872
27MP0005386_behavior/neurological_phenoty1.72052685
28MP0004924_abnormal_behavior1.72052685
29MP0002272_abnormal_nervous_system1.65588938
30MP0004085_abnormal_heartbeat1.59656478
31MP0004215_abnormal_myocardial_fiber1.57243276
32MP0000751_myopathy1.55114042
33MP0004084_abnormal_cardiac_muscle1.48266505
34MP0002751_abnormal_autonomic_nervous1.46276660
35* MP0005197_abnormal_uvea_morphology1.45179204
36MP0004036_abnormal_muscle_relaxation1.42854473
37MP0003137_abnormal_impulse_conducting1.41899648
38MP0004133_heterotaxia1.39845100
39MP0001968_abnormal_touch/_nociception1.37849508
40MP0003935_abnormal_craniofacial_develop1.37567084
41MP0001958_emphysema1.36930648
42MP0003075_altered_response_to1.35331473
43MP0003122_maternal_imprinting1.34962000
44MP0002557_abnormal_social/conspecific_i1.34757213
45* MP0002932_abnormal_joint_morphology1.34429680
46MP0003941_abnormal_skin_development1.34340702
47MP0008872_abnormal_physiological_respon1.31302613
48* MP0005508_abnormal_skeleton_morphology1.30938554
49MP0005409_darkened_coat_color1.30639535
50MP0003755_abnormal_palate_morphology1.27761150
51MP0005084_abnormal_gallbladder_morpholo1.27158221
52MP0003950_abnormal_plasma_membrane1.26720847
53MP0000049_abnormal_middle_ear1.26696858
54* MP0002233_abnormal_nose_morphology1.26493574
55MP0002108_abnormal_muscle_morphology1.26239701
56* MP0005248_abnormal_Harderian_gland1.24473675
57MP0002896_abnormal_bone_mineralization1.23573648
58MP0005595_abnormal_vascular_smooth1.21461464
59MP0006138_congestive_heart_failure1.18789221
60MP0005623_abnormal_meninges_morphology1.18633067
61MP0005394_taste/olfaction_phenotype1.17118808
62MP0005499_abnormal_olfactory_system1.17118808
63MP0001177_atelectasis1.16175374
64MP0001324_abnormal_eye_pigmentation1.15457359
65* MP0000534_abnormal_ureter_morphology1.15018142
66MP0008569_lethality_at_weaning1.12885463
67MP0001501_abnormal_sleep_pattern1.12616471
68MP0002139_abnormal_hepatobiliary_system1.11512496
69MP0010386_abnormal_urinary_bladder1.11215304
70MP0000462_abnormal_digestive_system1.09325394
71MP0005187_abnormal_penis_morphology1.08912361
72MP0003937_abnormal_limbs/digits/tail_de1.08864248
73MP0005620_abnormal_muscle_contractility1.08854378
74MP0002837_dystrophic_cardiac_calcinosis1.08064217
75MP0001544_abnormal_cardiovascular_syste1.07980208
76MP0005385_cardiovascular_system_phenoty1.07980208
77MP0004233_abnormal_muscle_weight1.07242488
78MP0001270_distended_abdomen1.06937066
79MP0005423_abnormal_somatic_nervous1.06705729
80MP0000733_abnormal_muscle_development1.05861450
81MP0002160_abnormal_reproductive_system1.05418453
82MP0001299_abnormal_eye_distance/1.04889633
83MP0003385_abnormal_body_wall1.04781016
84MP0003633_abnormal_nervous_system1.03754978
85* MP0002116_abnormal_craniofacial_bone1.03370144
86MP0000955_abnormal_spinal_cord1.03317412
87* MP0000163_abnormal_cartilage_morphology1.02766890
88MP0002734_abnormal_mechanical_nocicepti1.02759854
89MP0006054_spinal_hemorrhage1.02068828
90MP0004811_abnormal_neuron_physiology1.01827174
91MP0004885_abnormal_endolymph1.01750296
92MP0001661_extended_life_span1.01028729
93MP0002184_abnormal_innervation1.00979124
94MP0004484_altered_response_of1.00816324
95MP0008874_decreased_physiological_sensi0.99776014
96MP0000537_abnormal_urethra_morphology0.99266233
97MP0010630_abnormal_cardiac_muscle0.99137528
98MP0002090_abnormal_vision0.98545441
99MP0004087_abnormal_muscle_fiber0.97436208
100MP0003942_abnormal_urinary_system0.96328765
101MP0000428_abnormal_craniofacial_morphol0.95776726
102MP0002067_abnormal_sensory_capabilities0.94914803
103MP0002109_abnormal_limb_morphology0.94780419
104MP0005330_cardiomyopathy0.94620875
105MP0000569_abnormal_digit_pigmentation0.94165067
106MP0002972_abnormal_cardiac_muscle0.93905608
107MP0001346_abnormal_lacrimal_gland0.93411658
108MP0003938_abnormal_ear_development0.93296750
109MP0002127_abnormal_cardiovascular_syste0.92703943
110MP0005083_abnormal_biliary_tract0.91453024
111MP0001905_abnormal_dopamine_level0.91148847
112MP0005253_abnormal_eye_physiology0.90610407
113MP0004145_abnormal_muscle_electrophysio0.90287217
114MP0003119_abnormal_digestive_system0.90166096
115* MP0001286_abnormal_eye_development0.89067550
116MP0003890_abnormal_embryonic-extraembry0.88191657
117MP0002234_abnormal_pharynx_morphology0.88092381
118MP0000383_abnormal_hair_follicle0.87704581
119MP0000432_abnormal_head_morphology0.87542768
120MP0004130_abnormal_muscle_cell0.86434602
121MP0001440_abnormal_grooming_behavior0.86387019
122MP0003567_abnormal_fetal_cardiomyocyte0.85970759
123MP0002697_abnormal_eye_size0.85569970
124MP0005365_abnormal_bile_salt0.85555604
125MP0008775_abnormal_heart_ventricle0.85118718
126MP0004272_abnormal_basement_membrane0.84615574
127MP0003631_nervous_system_phenotype0.84515510
128MP0001970_abnormal_pain_threshold0.84401684
129MP0003646_muscle_fatigue0.84109881
130MP0005391_vision/eye_phenotype0.83881757
131MP0003283_abnormal_digestive_organ0.83227917
132MP0001293_anophthalmia0.83192308
133MP0002736_abnormal_nociception_after0.83106081
134MP0005257_abnormal_intraocular_pressure0.82695671
135MP0009053_abnormal_anal_canal0.81366270
136MP0002066_abnormal_motor_capabilities/c0.81217899
137MP0000647_abnormal_sebaceous_gland0.80561699
138MP0000467_abnormal_esophagus_morphology0.80122561
139MP0002092_abnormal_eye_morphology0.79714791
140MP0005451_abnormal_body_composition0.79245899
141MP0005535_abnormal_body_temperature0.79122421
142* MP0002114_abnormal_axial_skeleton0.78355725
143MP0002882_abnormal_neuron_morphology0.77934786
144MP0002115_abnormal_skeleton_extremities0.77139648
145MP0005174_abnormal_tail_pigmentation0.77045090
146MP0008875_abnormal_xenobiotic_pharmacok0.76646461
147MP0003011_delayed_dark_adaptation0.75296754
148MP0003690_abnormal_glial_cell0.74070980
149MP0000767_abnormal_smooth_muscle0.74053928
150MP0009780_abnormal_chondrocyte_physiolo0.72904715
151MP0003861_abnormal_nervous_system0.72693256
152* MP0002282_abnormal_trachea_morphology0.72653447
153MP0000749_muscle_degeneration0.72328117
154* MP0010030_abnormal_orbit_morphology0.71238549
155MP0002128_abnormal_blood_circulation0.71202026
156MP0000013_abnormal_adipose_tissue0.71188048
157MP0000778_abnormal_nervous_system0.70888661
158MP0000762_abnormal_tongue_morphology0.70834833
159MP0005166_decreased_susceptibility_to0.70778626
160MP0009384_cardiac_valve_regurgitation0.70645409
161MP0003718_maternal_effect0.70513954
162MP0001915_intracranial_hemorrhage0.69583690
163MP0002069_abnormal_eating/drinking_beha0.69166337
164MP0000230_abnormal_systemic_arterial0.68381612
165* MP0002249_abnormal_larynx_morphology0.68294199
166MP0002152_abnormal_brain_morphology0.68119544
167MP0009250_abnormal_appendicular_skeleto0.66661130
168MP0003115_abnormal_respiratory_system0.66278123
169MP0003279_aneurysm0.66206151

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.62168030
2Progressive inability to walk (HP:0002505)4.51780612
3* Annular pancreas (HP:0001734)4.29607916
4Atrioventricular block (HP:0001678)4.08817065
5Focal motor seizures (HP:0011153)4.02004630
6Torticollis (HP:0000473)3.55919426
7Hepatoblastoma (HP:0002884)3.51740371
8Arterial tortuosity (HP:0005116)3.48892095
9Atrial fibrillation (HP:0005110)3.47495413
10Facial diplegia (HP:0001349)3.42342846
11Prolonged QT interval (HP:0001657)3.40050831
12Resting tremor (HP:0002322)3.33689255
13Heart block (HP:0012722)3.29395722
14Primary atrial arrhythmia (HP:0001692)3.26539683
15Aortic dissection (HP:0002647)3.25466081
16Vascular tortuosity (HP:0004948)3.16100051
17Supraventricular tachycardia (HP:0004755)3.13665573
18Supraventricular arrhythmia (HP:0005115)3.05666809
19Anxiety (HP:0000739)2.98452968
20Abnormal atrioventricular conduction (HP:0005150)2.95398145
21Occipital encephalocele (HP:0002085)2.94032027
22Abnormal EKG (HP:0003115)2.93284278
23Ragged-red muscle fibers (HP:0003200)2.91688826
24Craniofacial dystonia (HP:0012179)2.87651033
25Focal dystonia (HP:0004373)2.87317495
26Ankyloglossia (HP:0010296)2.84978317
27Stereotypic behavior (HP:0000733)2.83281542
28Focal seizures (HP:0007359)2.82754758
29Ankle clonus (HP:0011448)2.81427979
30Bundle branch block (HP:0011710)2.79763890
31Overgrowth (HP:0001548)2.78280712
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.76156207
33Abnormality of the phalanges of the 2nd finger (HP:0009541)2.70221879
34Abnormal ciliary motility (HP:0012262)2.67130856
35Exercise-induced myalgia (HP:0003738)2.65838824
36Sudden death (HP:0001699)2.65509603
37Protrusio acetabuli (HP:0003179)2.64455662
38Pointed chin (HP:0000307)2.64215034
39* Abnormal pancreas size (HP:0012094)2.60239890
40Dysmetric saccades (HP:0000641)2.57300407
41Aplasia involving bones of the upper limbs (HP:0009823)2.55757157
42Aplasia of the phalanges of the hand (HP:0009802)2.55757157
43Aplasia involving bones of the extremities (HP:0009825)2.55757157
44Abnormal respiratory motile cilium morphology (HP:0005938)2.54057492
45Abnormal respiratory epithelium morphology (HP:0012253)2.54057492
46Depression (HP:0000716)2.53870307
47Spondylolisthesis (HP:0003302)2.52192069
48Supernumerary spleens (HP:0009799)2.51837967
49Action tremor (HP:0002345)2.51292581
50Impaired vibration sensation in the lower limbs (HP:0002166)2.50613879
51Broad-based gait (HP:0002136)2.50590492
52Rhinitis (HP:0012384)2.50580664
53Abnormal respiratory motile cilium physiology (HP:0012261)2.50121065
54Gout (HP:0001997)2.49332884
55Pancreatic cysts (HP:0001737)2.48291528
56Lower limb asymmetry (HP:0100559)2.47126397
57Absent/shortened dynein arms (HP:0200106)2.45653312
58Dynein arm defect of respiratory motile cilia (HP:0012255)2.45653312
59Ventricular fibrillation (HP:0001663)2.44089776
60Urinary bladder sphincter dysfunction (HP:0002839)2.42928224
61Limited hip movement (HP:0008800)2.41162991
62Abnormality of the middle phalanges of the toes (HP:0010183)2.41003314
63Premature rupture of membranes (HP:0001788)2.40425156
64Poor eye contact (HP:0000817)2.37074275
65Hip contracture (HP:0003273)2.34859458
66Limb hypertonia (HP:0002509)2.34628854
67Abnormality of the lower motor neuron (HP:0002366)2.34446638
68Congenital sensorineural hearing impairment (HP:0008527)2.33763519
69Central scotoma (HP:0000603)2.32463815
70Syncope (HP:0001279)2.30733827
71Dysdiadochokinesis (HP:0002075)2.29325249
72Obsessive-compulsive behavior (HP:0000722)2.26269116
73Bell-shaped thorax (HP:0001591)2.25304465
74Hypoplasia of the iris (HP:0007676)2.24895192
75Urinary urgency (HP:0000012)2.23179598
76Exercise-induced muscle cramps (HP:0003710)2.19938425
77Inability to walk (HP:0002540)2.18629872
78Abnormal social behavior (HP:0012433)2.18287673
79Impaired social interactions (HP:0000735)2.18287673
80Lower limb amyotrophy (HP:0007210)2.15650801
81Shallow orbits (HP:0000586)2.14564276
82Polygenic inheritance (HP:0010982)2.11830975
83Tubular atrophy (HP:0000092)2.11647833
84Soft skin (HP:0000977)2.10603075
85Febrile seizures (HP:0002373)2.10577451
86Abnormality of the renal medulla (HP:0100957)2.09922446
87Cutaneous finger syndactyly (HP:0010554)2.08529485
88Mitral valve prolapse (HP:0001634)2.08057503
89Abnormality of the ischium (HP:0003174)2.07171596
90Anterior segment dysgenesis (HP:0007700)2.05277739
91Renal duplication (HP:0000075)2.05000510
92Pancreatic fibrosis (HP:0100732)2.03460552
93Abnormality of the renal cortex (HP:0011035)2.02847644
94EMG: myopathic abnormalities (HP:0003458)2.02520969
95Vaginal atresia (HP:0000148)2.01356843
96Ventricular arrhythmia (HP:0004308)1.98376025
97Synostosis of carpal bones (HP:0005048)1.98248821
98Diastasis recti (HP:0001540)1.98226291
99Palpitations (HP:0001962)1.97347028
100Visual hallucinations (HP:0002367)1.96472884
101Periauricular skin pits (HP:0100277)1.96275583
102Preauricular pit (HP:0004467)1.96275583
103Delayed CNS myelination (HP:0002188)1.95876334
104Asymmetric growth (HP:0100555)1.95757769
105Tubulointerstitial fibrosis (HP:0005576)1.95057570
106Truncus arteriosus (HP:0001660)1.93351035
107Genital tract atresia (HP:0001827)1.93278526
108Impaired pain sensation (HP:0007328)1.93254411
109Abnormality of pain sensation (HP:0010832)1.93254411
110Abnormality of the parathyroid morphology (HP:0011766)1.92948672
111Osteomalacia (HP:0002749)1.89594848
112Abnormality of the left ventricular outflow tract (HP:0011103)1.89292910
113Subaortic stenosis (HP:0001682)1.89292910
114Blue irides (HP:0000635)1.87036136
115Aortic aneurysm (HP:0004942)1.86655926
116Aplasia/Hypoplasia of the lens (HP:0008063)1.85298816
117Incomplete penetrance (HP:0003829)1.84403259
118Preaxial foot polydactyly (HP:0001841)1.84400063
119Scanning speech (HP:0002168)1.82886679
120Asymmetry of the thorax (HP:0001555)1.82184015
121Gaze-evoked nystagmus (HP:0000640)1.81510517
122Aplasia/Hypoplasia of the tibia (HP:0005772)1.81254199
123Dysphonia (HP:0001618)1.81189272
124Clonus (HP:0002169)1.80305019
125Distal lower limb amyotrophy (HP:0008944)1.78887059
126Renal tubular acidosis (HP:0001947)1.78602046
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.78459365
128Decreased activity of mitochondrial respiratory chain (HP:0008972)1.78459365
129Abnormality of the proximal phalanges of the hand (HP:0009834)1.76802234
130Palpebral edema (HP:0100540)1.76756139
131Generalized tonic-clonic seizures (HP:0002069)1.75691081
132Hypophosphatemic rickets (HP:0004912)1.75171166
133Broad ribs (HP:0000885)1.74468375
134Nephronophthisis (HP:0000090)1.74161981
135Postural instability (HP:0002172)1.73995657
136Short hallux (HP:0010109)1.73937239
137Focal segmental glomerulosclerosis (HP:0000097)1.73350362
138Shawl scrotum (HP:0000049)1.72690632
139Gait imbalance (HP:0002141)1.72641779
140Renal dysplasia (HP:0000110)1.72132070
141Impaired vibratory sensation (HP:0002495)1.71489293
142Neoplasm of the adrenal gland (HP:0100631)1.70771722
143Bronchomalacia (HP:0002780)1.69673200
144Congenital primary aphakia (HP:0007707)1.69221926
145Medial flaring of the eyebrow (HP:0010747)1.69209051
146Cutaneous syndactyly (HP:0012725)1.68604585
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67936113
148Recurrent corneal erosions (HP:0000495)1.67362158
149Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.66419917
150Neuroblastic tumors (HP:0004376)1.66179710
151Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.66179710
152Neuroblastoma (HP:0003006)1.66179710
153Primitive neuroectodermal tumor (HP:0030065)1.66179710
154Abnormality of oral frenula (HP:0000190)1.65696239
155Tubulointerstitial abnormality (HP:0001969)1.63273501
156Papilledema (HP:0001085)1.63210534
157Facial shape deformation (HP:0011334)1.62757047
158Potter facies (HP:0002009)1.62757047
159Cystic liver disease (HP:0006706)1.61582193
160Aplasia/Hypoplasia of the hallux (HP:0008362)1.61175738
161Papillary thyroid carcinoma (HP:0002895)1.60558599
162Abnormality of the heme biosynthetic pathway (HP:0010472)1.60270836
163Abnormality of the upper arm (HP:0001454)1.59996807
164Renal hypoplasia (HP:0000089)1.59456058
165Broad metatarsal (HP:0001783)1.58844276
166Fibular aplasia (HP:0002990)1.58665274
167Midline defect of the nose (HP:0004122)1.58321843
168Abnormality of the calf musculature (HP:0001430)1.58082922
169True hermaphroditism (HP:0010459)1.57812378
170Neonatal hypoglycemia (HP:0001998)1.57461660
171Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.57457505
172Abnormality of the humerus (HP:0003063)1.57213169
173Buphthalmos (HP:0000557)1.56772095
174Tarsal synostosis (HP:0008368)1.55653213
175Hyperaldosteronism (HP:0000859)1.55496301
176Synostosis involving bones of the lower limbs (HP:0009138)1.54735976
177Synostosis involving bones of the feet (HP:0009140)1.54735976
178Short foot (HP:0001773)1.54171574
179Bladder diverticulum (HP:0000015)1.52937854
180White forelock (HP:0002211)1.52536673
181Knee flexion contracture (HP:0006380)1.52257816
182Pheochromocytoma (HP:0002666)1.52066084
183Pulmonic stenosis (HP:0001642)1.52044370
184Wormian bones (HP:0002645)1.51534561
185Scotoma (HP:0000575)1.51126394
186Amyotrophic lateral sclerosis (HP:0007354)1.50053778
187Vertebral arch anomaly (HP:0008438)1.49790855
188Morphological abnormality of the middle ear (HP:0008609)1.49667263
189Hyporeflexia of lower limbs (HP:0002600)1.49151848
190Aplasia of the musculature (HP:0100854)1.49133322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.22563208
2NTRK33.07650430
3CASK2.82556370
4PNCK2.66887896
5MAP3K92.65416952
6ACVR1B2.62869600
7BMPR1B2.47184978
8NEK92.37432736
9PRKD32.36274223
10DAPK22.28460920
11CAMKK12.28325319
12STK38L2.18607707
13KSR12.15522449
14SGK22.09130582
15KSR22.07337839
16LATS12.02637802
17PLK21.94115243
18SGK31.94011243
19CAMKK21.88095490
20MINK11.80214539
21TRIB31.74094035
22MAP3K131.70422243
23PDK21.70297298
24SGK4941.70212766
25SGK2231.70212766
26ARAF1.67405671
27SIK31.64679347
28FLT31.47899175
29NEK11.43251314
30MET1.40255824
31TAOK11.40026247
32TIE11.39475483
33PINK11.38731740
34TAOK21.35357560
35LMTK21.33181640
36PRPF4B1.29082432
37FRK1.26899863
38ERBB41.26263709
39PRKCH1.26258687
40FGFR21.20901351
41MAP3K121.17749241
42FES1.17642776
43CDK51.16913294
44PHKG11.16877515
45PHKG21.16877515
46MAPK151.13888768
47PIK3CG1.13157860
48NTRK21.13001617
49ERBB31.12826365
50TRPM71.12400226
51MAP3K21.10483999
52MARK11.10423548
53NLK1.10131157
54MELK1.08165835
55RIPK41.05188031
56STK241.04760432
57STK381.02692278
58MUSK1.01616096
59PKN21.00067332
60NTRK10.99518301
61MAP3K40.97947715
62CAMK1G0.96477801
63MYLK0.95440855
64WNK10.94500844
65MAP2K40.93505077
66PTK20.92937955
67MAP3K70.87874831
68SIK20.87695248
69BRSK20.87090985
70SGK10.86977137
71BMPR20.84849254
72DAPK10.84777892
73FGFR30.84074994
74PDGFRA0.83858563
75TYRO30.83701645
76PIK3CA0.80140345
77WEE10.79943197
78MAP2K10.76997637
79WNK30.75384597
80PAK30.75078554
81CAMK2A0.73019689
82RAF10.70996017
83PDPK10.70008687
84MAP2K70.69901228
85OBSCN0.69762085
86GRK10.69266858
87PAK60.69091687
88TRIM280.68775918
89BCR0.68675409
90DYRK1A0.68119832
91PDGFRB0.67961747
92STK30.67230280
93BCKDK0.65952725
94EPHB20.65528312
95MKNK10.65504598
96PRKCG0.64563503
97CAMK2B0.64116853
98TNIK0.62814818
99AKT30.62667178
100PTK2B0.62127892
101DMPK0.61894937
102EPHA20.61244166
103PDK10.60473442
104MAPK130.59873968
105PRKCE0.59322957
106CAMK40.59274189
107NEK60.59197466
108CAMK10.59040151
109FER0.58122920
110STK390.58005485
111RET0.57491702
112TGFBR10.56632741
113LATS20.56425415
114PAK20.56399710
115ALK0.55618275
116CSNK1G20.54134380
117PRKD10.53849655
118TGFBR20.53724479
119FGFR10.52642730
120ERBB20.52529434
121DYRK1B0.52127564
122RPS6KA30.51977115
123PBK0.49792994
124BRD40.49254216
125RIPK10.48596828
126GRK70.48441777
127BRAF0.48001966
128PRKAA10.46225324
129CDK180.45848187
130MOS0.45505016
131MAP2K30.44351842
132UHMK10.43955271
133DDR20.42757814
134CSNK1G10.42312986
135PRKCZ0.42107551
136PRKD20.41467449
137CAMK2D0.40589726
138CAMK2G0.40083732
139MARK20.39904827
140CSNK1D0.39857036
141PTK60.39830752
142MAPK70.38518481
143TTN0.38059742
144DAPK30.38036094
145WNK40.37984699
146ROCK20.37688065
147CDK140.37593546
148ROCK10.37116484

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.51531119
2TGF-beta signaling pathway_Homo sapiens_hsa043502.65231107
3ECM-receptor interaction_Homo sapiens_hsa045122.53653379
4Morphine addiction_Homo sapiens_hsa050322.52553010
5Cocaine addiction_Homo sapiens_hsa050302.38455648
6Circadian entrainment_Homo sapiens_hsa047132.37627898
7Nitrogen metabolism_Homo sapiens_hsa009102.30906353
8GABAergic synapse_Homo sapiens_hsa047272.30526059
9Amphetamine addiction_Homo sapiens_hsa050312.20075766
10Basal cell carcinoma_Homo sapiens_hsa052172.16165803
11Renin secretion_Homo sapiens_hsa049242.03224095
12Dopaminergic synapse_Homo sapiens_hsa047281.98599430
13Long-term potentiation_Homo sapiens_hsa047201.96482621
14Glutamatergic synapse_Homo sapiens_hsa047241.95461005
15Cholinergic synapse_Homo sapiens_hsa047251.94210619
16Hedgehog signaling pathway_Homo sapiens_hsa043401.87273178
17Nicotine addiction_Homo sapiens_hsa050331.85365716
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.78976072
19Butanoate metabolism_Homo sapiens_hsa006501.76097916
20Synaptic vesicle cycle_Homo sapiens_hsa047211.69024737
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68774348
22Adherens junction_Homo sapiens_hsa045201.67918997
23Salivary secretion_Homo sapiens_hsa049701.62523698
24Oxytocin signaling pathway_Homo sapiens_hsa049211.60040269
25Calcium signaling pathway_Homo sapiens_hsa040201.57399100
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54784777
27Dilated cardiomyopathy_Homo sapiens_hsa054141.54565427
28Wnt signaling pathway_Homo sapiens_hsa043101.50354037
29Focal adhesion_Homo sapiens_hsa045101.49889511
30Gap junction_Homo sapiens_hsa045401.47886732
31Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.46157264
32Gastric acid secretion_Homo sapiens_hsa049711.45530988
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42637373
34Histidine metabolism_Homo sapiens_hsa003401.39279097
35Protein digestion and absorption_Homo sapiens_hsa049741.38372426
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30380768
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28812305
38GnRH signaling pathway_Homo sapiens_hsa049121.21634349
39Cardiac muscle contraction_Homo sapiens_hsa042601.18518520
40Insulin secretion_Homo sapiens_hsa049111.17252703
41cAMP signaling pathway_Homo sapiens_hsa040241.16960927
42Proteoglycans in cancer_Homo sapiens_hsa052051.14530908
43Serotonergic synapse_Homo sapiens_hsa047261.13067081
44Lysine degradation_Homo sapiens_hsa003101.12019688
45Taste transduction_Homo sapiens_hsa047421.09768110
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09557353
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09279083
48Long-term depression_Homo sapiens_hsa047301.08900462
49cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08242580
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07877465
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07195348
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05531236
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05530645
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.05530349
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05455377
56Melanogenesis_Homo sapiens_hsa049161.02732201
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02526740
58* Pathways in cancer_Homo sapiens_hsa052001.01306214
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01062821
60Arginine biosynthesis_Homo sapiens_hsa002201.00885842
61Propanoate metabolism_Homo sapiens_hsa006401.00490841
62Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98118951
63Selenocompound metabolism_Homo sapiens_hsa004500.97008017
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.93519572
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89276872
66Colorectal cancer_Homo sapiens_hsa052100.88572524
67Bile secretion_Homo sapiens_hsa049760.88227631
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.87880135
69Fatty acid degradation_Homo sapiens_hsa000710.87462565
70Glioma_Homo sapiens_hsa052140.84867006
71Amoebiasis_Homo sapiens_hsa051460.83134450
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81847741
73Rap1 signaling pathway_Homo sapiens_hsa040150.80733699
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.80388557
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78553029
76Axon guidance_Homo sapiens_hsa043600.76838702
77PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76823855
78* Small cell lung cancer_Homo sapiens_hsa052220.75684850
79Tryptophan metabolism_Homo sapiens_hsa003800.74592615
80Glucagon signaling pathway_Homo sapiens_hsa049220.73178871
81Alcoholism_Homo sapiens_hsa050340.71772831
82MicroRNAs in cancer_Homo sapiens_hsa052060.70037348
83Estrogen signaling pathway_Homo sapiens_hsa049150.69832552
84Oocyte meiosis_Homo sapiens_hsa041140.69790625
85Melanoma_Homo sapiens_hsa052180.69696344
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69641170
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64010442
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.63798877
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63633094
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63081840
91Thyroid cancer_Homo sapiens_hsa052160.62599695
92* Non-small cell lung cancer_Homo sapiens_hsa052230.62183702
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61907101
94Phototransduction_Homo sapiens_hsa047440.61594048
95Fatty acid metabolism_Homo sapiens_hsa012120.60196101
96Type II diabetes mellitus_Homo sapiens_hsa049300.59011277
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.58030984
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58008704
99Circadian rhythm_Homo sapiens_hsa047100.57478241
100Insulin signaling pathway_Homo sapiens_hsa049100.57462633
101ErbB signaling pathway_Homo sapiens_hsa040120.57363631
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56430052
103Retinol metabolism_Homo sapiens_hsa008300.56303903
104Complement and coagulation cascades_Homo sapiens_hsa046100.56151881
105Pancreatic secretion_Homo sapiens_hsa049720.55965640
106ABC transporters_Homo sapiens_hsa020100.55472298
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54894337
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54841674
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54807724
110Inositol phosphate metabolism_Homo sapiens_hsa005620.53985554
111Starch and sucrose metabolism_Homo sapiens_hsa005000.53541893
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53278013
113Pyruvate metabolism_Homo sapiens_hsa006200.52688705
114Thyroid hormone synthesis_Homo sapiens_hsa049180.52379496
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50942667
116Endometrial cancer_Homo sapiens_hsa052130.50366938
117Renal cell carcinoma_Homo sapiens_hsa052110.50044572
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49617912
119PPAR signaling pathway_Homo sapiens_hsa033200.48874718
120Ras signaling pathway_Homo sapiens_hsa040140.48295630
121Tight junction_Homo sapiens_hsa045300.48162037
122Prostate cancer_Homo sapiens_hsa052150.47012575
123beta-Alanine metabolism_Homo sapiens_hsa004100.46615419
124Ovarian steroidogenesis_Homo sapiens_hsa049130.46201373
125Platelet activation_Homo sapiens_hsa046110.45949250
126Regulation of autophagy_Homo sapiens_hsa041400.44787774
127Carbon metabolism_Homo sapiens_hsa012000.43390680
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43060582
129Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42802770
130mTOR signaling pathway_Homo sapiens_hsa041500.41981297
131Galactose metabolism_Homo sapiens_hsa000520.41436825
132MAPK signaling pathway_Homo sapiens_hsa040100.40425342
133VEGF signaling pathway_Homo sapiens_hsa043700.39883981
134Hippo signaling pathway_Homo sapiens_hsa043900.39716178
135Insulin resistance_Homo sapiens_hsa049310.38876374
136Chemical carcinogenesis_Homo sapiens_hsa052040.38491072

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