RARA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12583478
2positive regulation by symbiont of host defense response (GO:0052509)5.46317961
3modulation by symbiont of host defense response (GO:0052031)5.46317961
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.46317961
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.46317961
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.46317961
7modulation by symbiont of host immune response (GO:0052553)5.46317961
8detection of other organism (GO:0098543)4.74217456
9response to peptidoglycan (GO:0032494)4.59617593
10detection of bacterium (GO:0016045)4.59066216
11macrophage activation involved in immune response (GO:0002281)4.53224786
12neutrophil activation involved in immune response (GO:0002283)4.46381791
13detection of external biotic stimulus (GO:0098581)4.14967689
14detection of molecule of bacterial origin (GO:0032490)4.12407821
15regulation of interferon-beta biosynthetic process (GO:0045357)3.82870714
16regulation of integrin activation (GO:0033623)3.70564512
17detection of biotic stimulus (GO:0009595)3.64566219
18negative regulation of lymphocyte mediated immunity (GO:0002707)3.63838660
19embryonic process involved in female pregnancy (GO:0060136)3.63351691
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60609466
21neutrophil activation (GO:0042119)3.55512588
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.54684407
23response to host immune response (GO:0052572)3.54684407
24leukocyte migration involved in inflammatory response (GO:0002523)3.52088323
25response to muramyl dipeptide (GO:0032495)3.47728104
26response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.45246246
27response to host (GO:0075136)3.45246246
28response to host defenses (GO:0052200)3.45246246
29regulation of mast cell degranulation (GO:0043304)3.45183559
30positive thymic T cell selection (GO:0045059)3.42772603
31respiratory burst (GO:0045730)3.40381690
32immunoglobulin mediated immune response (GO:0016064)3.39578449
33germinal center formation (GO:0002467)3.35999147
34negative regulation of leukocyte mediated immunity (GO:0002704)3.34415778
35apoptotic process involved in morphogenesis (GO:0060561)3.33217668
36response to interleukin-15 (GO:0070672)3.28693132
37granulocyte activation (GO:0036230)3.26881188
38embryonic placenta development (GO:0001892)3.23679113
39establishment of apical/basal cell polarity (GO:0035089)3.23445430
40response to laminar fluid shear stress (GO:0034616)3.23311741
41regulation of leukocyte degranulation (GO:0043300)3.22306351
42regulation of myeloid leukocyte mediated immunity (GO:0002886)3.21269178
43macrophage activation (GO:0042116)3.20160953
44anatomical structure regression (GO:0060033)3.18716696
45cellular response to type I interferon (GO:0071357)3.17533605
46type I interferon signaling pathway (GO:0060337)3.17533605
47response to type I interferon (GO:0034340)3.16780007
48myeloid cell activation involved in immune response (GO:0002275)3.16691877
49positive regulation of SMAD protein import into nucleus (GO:0060391)3.11627049
50regulation of mast cell activation involved in immune response (GO:0033006)3.10646975
51positive regulation of histone deacetylation (GO:0031065)3.10497837
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.09040527
53regulation of gamma-delta T cell differentiation (GO:0045586)3.04182963
54lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04003432
55positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.03017242
56antigen processing and presentation via MHC class Ib (GO:0002475)3.00779227
57trophectodermal cell differentiation (GO:0001829)2.97694989
58neutrophil mediated immunity (GO:0002446)2.94879496
59proline biosynthetic process (GO:0006561)2.94811538
60heterochromatin organization (GO:0070828)2.93936862
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91478584
62B cell receptor signaling pathway (GO:0050853)2.90266224
63microglial cell activation (GO:0001774)2.90197402
64cellular response to interleukin-15 (GO:0071350)2.89809405
65regulation of SMAD protein import into nucleus (GO:0060390)2.89632053
66regulation of T cell tolerance induction (GO:0002664)2.89578488
67negative regulation of T cell mediated immunity (GO:0002710)2.89563344
68production of molecular mediator involved in inflammatory response (GO:0002532)2.89286535
69negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88631916
70positive regulation of Cdc42 GTPase activity (GO:0043089)2.87359871
71regulation of translational fidelity (GO:0006450)2.86532735
72regulation of gene silencing by miRNA (GO:0060964)2.86369982
73regulation of gene silencing by RNA (GO:0060966)2.86369982
74regulation of posttranscriptional gene silencing (GO:0060147)2.86369982
75regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85024432
76negative regulation of cytokine production involved in immune response (GO:0002719)2.83835012
77regulation of gamma-delta T cell activation (GO:0046643)2.82664470
78regulation of tolerance induction (GO:0002643)2.81895298
79protein heterotrimerization (GO:0070208)2.80048109
80pre-miRNA processing (GO:0031054)2.79765309
81NIK/NF-kappaB signaling (GO:0038061)2.79349688
82positive regulation of mast cell activation (GO:0033005)2.79007924
83negative regulation of type 2 immune response (GO:0002829)2.76084271
84regulation of regulated secretory pathway (GO:1903305)2.75156283
85maternal placenta development (GO:0001893)2.75031339
86negative regulation of interleukin-6 production (GO:0032715)2.74030768
87positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73849316
88defense response to protozoan (GO:0042832)2.73314478
89interferon-gamma-mediated signaling pathway (GO:0060333)2.72408416
90regulation of T cell mediated cytotoxicity (GO:0001914)2.71758178
91endothelial cell chemotaxis (GO:0035767)2.70909799
92positive regulation of cellular amide metabolic process (GO:0034250)2.69836322
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.69680156
94thymic T cell selection (GO:0045061)2.68871180
95leukocyte aggregation (GO:0070486)2.68694069
96regulation of mast cell activation (GO:0033003)2.68312221
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.67732531
98negative regulation of toll-like receptor signaling pathway (GO:0034122)2.67507397
99negative regulation of interleukin-12 production (GO:0032695)2.65437884
100positive regulation of gamma-delta T cell activation (GO:0046645)2.64536410
101leukocyte degranulation (GO:0043299)2.61555772
102endothelial tube morphogenesis (GO:0061154)2.61409831
103morphogenesis of an endothelium (GO:0003159)2.61409831
104regulation of interleukin-12 biosynthetic process (GO:0045075)2.59201692
105endodermal cell differentiation (GO:0035987)2.58663067
106negative regulation of innate immune response (GO:0045824)2.58416191
107regulation of macrophage cytokine production (GO:0010935)2.56170951
108positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.55688596
109regulation of B cell differentiation (GO:0045577)2.53052592
110negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.52018521
111negative regulation of T-helper cell differentiation (GO:0045623)2.52018521
112* regulation of T-helper 2 cell differentiation (GO:0045628)2.49405454
113antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48133145
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.48133145
115establishment or maintenance of monopolar cell polarity (GO:0061339)2.47445360
116establishment of monopolar cell polarity (GO:0061162)2.47445360
117paraxial mesoderm development (GO:0048339)2.45924458
118cellular extravasation (GO:0045123)2.45885284
119dosage compensation (GO:0007549)2.45555923
120apoptotic process involved in development (GO:1902742)2.45045852
121antigen processing and presentation of endogenous antigen (GO:0019883)2.43600600
122nodal signaling pathway (GO:0038092)2.42893468
123positive T cell selection (GO:0043368)2.40857851
124negative regulation of stress fiber assembly (GO:0051497)2.40844392
125basement membrane organization (GO:0071711)2.40186986
126mRNA stabilization (GO:0048255)2.39644583
127RNA stabilization (GO:0043489)2.39644583
128planar cell polarity pathway involved in neural tube closure (GO:0090179)2.39003469
129regulation of hippo signaling (GO:0035330)2.36127406
130regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.34319785
131response to UV-C (GO:0010225)2.32757930
132positive regulation of lamellipodium assembly (GO:0010592)2.31796083
133positive regulation of protein deacetylation (GO:0090312)2.31534643
134negative regulation of cell killing (GO:0031342)2.30944155
135negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30944155
136polarized epithelial cell differentiation (GO:0030859)2.28374274
1373-UTR-mediated mRNA stabilization (GO:0070935)2.27192904
138positive regulation of protein homooligomerization (GO:0032464)2.25988022
139negative regulation of fatty acid transport (GO:2000192)2.24907852
140negative thymic T cell selection (GO:0045060)2.22158804
141nuclear pore complex assembly (GO:0051292)2.21967720
142blood vessel endothelial cell migration (GO:0043534)2.21772949
143tolerance induction (GO:0002507)2.21644432
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.20989328
145positive regulation of epithelial to mesenchymal transition (GO:0010718)2.19739446
146positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.19268548
147T cell apoptotic process (GO:0070231)2.18702014
148negative T cell selection (GO:0043383)2.16807658
149regulation of B cell receptor signaling pathway (GO:0050855)2.16794139
150regulation of cholesterol homeostasis (GO:2000188)2.15466721
151positive regulation of endothelial cell apoptotic process (GO:2000353)2.15189232
152leukocyte cell-cell adhesion (GO:0007159)2.14961744
153negative regulation of erythrocyte differentiation (GO:0045647)2.13976775
154negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.12103914
155response to fluid shear stress (GO:0034405)2.11688820
156T cell selection (GO:0045058)2.10529938
157establishment of endothelial barrier (GO:0061028)2.10208961
158nuclear pore organization (GO:0006999)2.09812744
159germ cell migration (GO:0008354)2.09264387
160negative regulation of glial cell proliferation (GO:0060253)2.08732967
161regulation of tight junction assembly (GO:2000810)2.08052977
162* intracellular estrogen receptor signaling pathway (GO:0030520)2.07551166
163positive regulation of T cell apoptotic process (GO:0070234)2.07326287
164cell-substrate junction assembly (GO:0007044)2.07154435
165* apoptotic cell clearance (GO:0043277)2.06359186
166regulation of RNA export from nucleus (GO:0046831)2.05821198
167regulation of protein heterodimerization activity (GO:0043497)2.05485795
168adherens junction assembly (GO:0034333)2.05074936
169negative regulation of heart growth (GO:0061117)2.04740918
170negative regulation of cardiac muscle tissue growth (GO:0055022)2.04740918
171mitotic nuclear envelope disassembly (GO:0007077)2.03921605
172skin morphogenesis (GO:0043589)2.03783944
173cell migration involved in sprouting angiogenesis (GO:0002042)2.03178309
174Arp2/3 complex-mediated actin nucleation (GO:0034314)2.03003257
175developmental programmed cell death (GO:0010623)2.02474184
176negative regulation of phagocytosis (GO:0050765)2.02016804
177regulation of stem cell maintenance (GO:2000036)2.01698750
178positive regulation by host of viral transcription (GO:0043923)2.01482388
179NLS-bearing protein import into nucleus (GO:0006607)2.01474719

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.41575702
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.32626921
3MYC_22102868_ChIP-Seq_BL_Human3.31389708
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.13817256
5E2F7_22180533_ChIP-Seq_HELA_Human2.87808825
6VDR_21846776_ChIP-Seq_THP-1_Human2.65413651
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.50275374
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.44240702
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.33874694
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.30772193
11* TCF7_22412390_ChIP-Seq_EML_Mouse2.20843359
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15406483
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15406483
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15406483
15* ELK3_25401928_ChIP-Seq_HUVEC_Human2.14247423
16* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.06395624
17* KDM2B_26808549_Chip-Seq_DND41_Human2.02542161
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.00675464
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99220179
20* MAF_26560356_Chip-Seq_TH1_Human1.94265353
21* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83694179
22* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81864614
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78711604
24UTX_26944678_Chip-Seq_JUKART_Human1.76420078
25* LXR_22292898_ChIP-Seq_THP-1_Human1.75181480
26SCL_19346495_ChIP-Seq_HPC-7_Human1.69518048
27* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68942842
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66713919
29RACK7_27058665_Chip-Seq_MCF-7_Human1.61534507
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61419679
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.59684767
32* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59222981
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.58656050
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57890176
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.56235717
36MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53730398
37* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.52453482
38VDR_24763502_ChIP-Seq_THP-1_Human1.52413533
39EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.51371195
40TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50023801
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49365611
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.49077932
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.48462792
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47264893
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45970447
46* GATA1_19941827_ChIP-Seq_MEL_Mouse1.45352392
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42704632
48CLOCK_20551151_ChIP-Seq_293T_Human1.42013196
49* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40561087
50IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40069435
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38898904
52PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37962103
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37285264
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.36254692
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36197141
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.36195362
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.35559983
58MYB_26560356_Chip-Seq_TH1_Human1.35107642
59* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34936427
60NCOR1_26117541_ChIP-Seq_K562_Human1.34025357
61* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33932493
62BCOR_27268052_Chip-Seq_Bcells_Human1.33487242
63P68_20966046_ChIP-Seq_HELA_Human1.33112253
64ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32840947
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32452592
66IRF8_22096565_ChIP-ChIP_GC-B_Human1.32358311
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32212231
68MYB_26560356_Chip-Seq_TH2_Human1.32003900
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31059677
70BCL6_27268052_Chip-Seq_Bcells_Human1.30395914
71MAF_26560356_Chip-Seq_TH2_Human1.30316579
72KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27371266
73* ATF3_27146783_Chip-Seq_COLON_Human1.27198494
74* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27050054
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26216791
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24646615
77SMC4_20622854_ChIP-Seq_HELA_Human1.24498275
78* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23425139
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22897140
80* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22771100
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21923382
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.21748882
83* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21703983
84* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21679915
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.21517430
86VDR_24787735_ChIP-Seq_THP-1_Human1.21462390
87MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21033310
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20896434
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20510849
90PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18778837
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.18571518
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18348545
93* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18119665
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.17795225
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16318152
96RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.16144696
97MYC_18555785_ChIP-Seq_MESCs_Mouse1.15510632
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15498360
99* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15052005
100GATA1_19941826_ChIP-Seq_K562_Human1.14849599
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14548501
102* RXR_22158963_ChIP-Seq_LIVER_Mouse1.14531986
103FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12341476
104NOTCH1_21737748_ChIP-Seq_TLL_Human1.12313825
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11202530
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11184668
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10381644
108* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09548969
109ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.07414313
110SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06798159
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06658180
112ESR1_20079471_ChIP-ChIP_T-47D_Human1.05125762
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05020729
114BP1_19119308_ChIP-ChIP_Hs578T_Human1.04813430
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03947179
116TET1_21451524_ChIP-Seq_MESCs_Mouse1.03603789
117GATA3_27048872_Chip-Seq_THYMUS_Human1.03106982
118UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01671076
119CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01571399
120* RUNX_20019798_ChIP-Seq_JUKART_Human1.01514335
121TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99875352
122TP53_22127205_ChIP-Seq_IMR90_Human0.99171057
123* PU_27001747_Chip-Seq_BMDM_Mouse0.98389931
124CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97871859
125* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97809731
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97330041
127SPI1_23547873_ChIP-Seq_NB4_Human0.96884503
128IRF8_27001747_Chip-Seq_BMDM_Mouse0.96330806
129SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96309346
130CREB1_26743006_Chip-Seq_LNCaP_Human0.96053982
131IRF8_21731497_ChIP-ChIP_J774_Mouse0.95904229
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95882705
133* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94644433
134NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94215790
135SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93221814
136* KDM2B_26808549_Chip-Seq_K562_Human0.92289371
137* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91968628
138* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91747245
139SPI1_23127762_ChIP-Seq_K562_Human0.91483165
140KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91420636
141CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90474954
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89895282
143PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.89800908

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.10704374
2MP0003705_abnormal_hypodermis_morpholog3.32977461
3MP0005076_abnormal_cell_differentiation2.86501752
4MP0009278_abnormal_bone_marrow2.74340068
5MP0010352_gastrointestinal_tract_polyps2.63804804
6MP0003191_abnormal_cellular_cholesterol2.57229824
7MP0009785_altered_susceptibility_to2.31105781
8MP0005451_abnormal_body_composition2.29376225
9MP0003303_peritoneal_inflammation2.23558000
10MP0008260_abnormal_autophagy2.23365753
11MP0005671_abnormal_response_to2.17984303
12MP0008438_abnormal_cutaneous_collagen2.15410568
13MP0003436_decreased_susceptibility_to2.14316756
14MP0003172_abnormal_lysosome_physiology2.10489546
15MP0003566_abnormal_cell_adhesion2.10326695
16MP0003300_gastrointestinal_ulcer1.99947154
17MP0010030_abnormal_orbit_morphology1.99588168
18MP0000685_abnormal_immune_system1.96005435
19MP0005058_abnormal_lysosome_morphology1.86921911
20MP0005023_abnormal_wound_healing1.82971253
21MP0002148_abnormal_hypersensitivity_rea1.79120013
22MP0005464_abnormal_platelet_physiology1.69757590
23MP0003279_aneurysm1.69511304
24MP0004381_abnormal_hair_follicle1.67113362
25MP0002405_respiratory_system_inflammati1.55421717
26MP0003453_abnormal_keratinocyte_physiol1.55039469
27MP0003183_abnormal_peptide_metabolism1.54525786
28MP0002396_abnormal_hematopoietic_system1.51808030
29MP0003866_abnormal_defecation1.51791901
30MP0005387_immune_system_phenotype1.50129462
31MP0001790_abnormal_immune_system1.50129462
32MP0002998_abnormal_bone_remodeling1.49166390
33MP0005397_hematopoietic_system_phenotyp1.45798174
34MP0001545_abnormal_hematopoietic_system1.45798174
35MP0003763_abnormal_thymus_physiology1.41386335
36MP0001800_abnormal_humoral_immune1.40291803
37MP0000465_gastrointestinal_hemorrhage1.38123204
38MP0000733_abnormal_muscle_development1.34448542
39MP0004510_myositis1.33750036
40MP0008469_abnormal_protein_level1.31344929
41MP0005275_abnormal_skin_tensile1.29933421
42MP0003828_pulmonary_edema1.28792893
43MP0003448_altered_tumor_morphology1.28346517
44MP0001851_eye_inflammation1.27903588
45MP0004883_abnormal_blood_vessel1.26189620
46MP0004808_abnormal_hematopoietic_stem1.25160274
47MP0010155_abnormal_intestine_physiology1.24745518
48MP0003075_altered_response_to1.23802299
49MP0004197_abnormal_fetal_growth/weight/1.22498238
50MP0000490_abnormal_crypts_of1.21619127
51MP0000858_altered_metastatic_potential1.21429450
52MP0005310_abnormal_salivary_gland1.20399031
53MP0008057_abnormal_DNA_replication1.19422831
54MP0002452_abnormal_antigen_presenting1.19282448
55MP0009764_decreased_sensitivity_to1.19063516
56MP0010307_abnormal_tumor_latency1.18856914
57MP0001873_stomach_inflammation1.17847012
58MP0009333_abnormal_splenocyte_physiolog1.17204495
59MP0002086_abnormal_extraembryonic_tissu1.16513232
60MP0004947_skin_inflammation1.16217591
61MP0002933_joint_inflammation1.15441313
62MP0002060_abnormal_skin_morphology1.14089585
63MP0002166_altered_tumor_susceptibility1.13542717
64MP0002398_abnormal_bone_marrow1.13093494
65MP0001835_abnormal_antigen_presentation1.11957674
66MP0000767_abnormal_smooth_muscle1.10646982
67MP0003091_abnormal_cell_migration1.08362745
68MP0005164_abnormal_response_to1.05723913
69MP0001849_ear_inflammation1.05075288
70MP0005166_decreased_susceptibility_to1.04929131
71MP0002420_abnormal_adaptive_immunity1.04707965
72MP0001819_abnormal_immune_cell1.03754449
73MP0004264_abnormal_extraembryonic_tissu1.02462537
74MP0002722_abnormal_immune_system1.02194000
75MP0005000_abnormal_immune_tolerance1.01955398
76MP0005503_abnormal_tendon_morphology1.01467484
77MP0000689_abnormal_spleen_morphology1.00866199
78MP0002088_abnormal_embryonic_growth/wei1.00312018
79* MP0000703_abnormal_thymus_morphology0.99752659
80MP0003984_embryonic_growth_retardation0.99652272
81MP0002723_abnormal_immune_serum0.99554426
82MP0004858_abnormal_nervous_system0.99325630
83MP0005380_embryogenesis_phenotype0.97850202
84MP0001672_abnormal_embryogenesis/_devel0.97850202
85MP0000350_abnormal_cell_proliferation0.97848387
86* MP0002925_abnormal_cardiovascular_devel0.97798655
87MP0005083_abnormal_biliary_tract0.97225548
88MP0003045_fibrosis0.97027648
89MP0001533_abnormal_skeleton_physiology0.96955458
90MP0000716_abnormal_immune_system0.96671008
91MP0005025_abnormal_response_to0.95960401
92MP0001853_heart_inflammation0.95891281
93MP0004185_abnormal_adipocyte_glucose0.94931728
94* MP0005390_skeleton_phenotype0.91818850
95MP0002419_abnormal_innate_immunity0.91551266
96MP0001958_emphysema0.90403551
97MP0001915_intracranial_hemorrhage0.89071978
98* MP0002085_abnormal_embryonic_tissue0.88681826
99MP0001697_abnormal_embryo_size0.88679424
100MP0005377_hearing/vestibular/ear_phenot0.88605648
101MP0003878_abnormal_ear_physiology0.88605648
102MP0002277_abnormal_respiratory_mucosa0.88372407
103MP0001730_embryonic_growth_arrest0.88357735
104MP0001243_abnormal_dermal_layer0.88321204
105* MP0005508_abnormal_skeleton_morphology0.88242377
106MP0002429_abnormal_blood_cell0.87832864
107MP0002084_abnormal_developmental_patter0.87159098
108MP0010630_abnormal_cardiac_muscle0.85566965
109MP0000249_abnormal_blood_vessel0.85535010
110MP0009840_abnormal_foam_cell0.85501617
111MP0002019_abnormal_tumor_incidence0.85233492
112MP0003077_abnormal_cell_cycle0.84951798
113MP0003567_abnormal_fetal_cardiomyocyte0.84047592
114MP0001845_abnormal_inflammatory_respons0.83756398
115MP0002006_tumorigenesis0.83386461
116MP0004957_abnormal_blastocyst_morpholog0.83033726
117MP0004272_abnormal_basement_membrane0.82990211
118MP0001348_abnormal_lacrimal_gland0.82884623
119MP0008961_abnormal_basal_metabolism0.81436669
120MP0003690_abnormal_glial_cell0.80983054
121MP0003941_abnormal_skin_development0.80162947
122MP0003795_abnormal_bone_structure0.79966548
123MP0002877_abnormal_melanocyte_morpholog0.79775902
124MP0000477_abnormal_intestine_morphology0.79367745
125MP0000343_altered_response_to0.79356335
126MP0001293_anophthalmia0.77696301
127MP0008004_abnormal_stomach_pH0.77426456
128MP0006082_CNS_inflammation0.76650698
129MP0005623_abnormal_meninges_morphology0.76649333
130MP0002138_abnormal_hepatobiliary_system0.76591248
131* MP0002282_abnormal_trachea_morphology0.75604869
132MP0008874_decreased_physiological_sensi0.75044358
133MP0005409_darkened_coat_color0.74797405
134MP0002089_abnormal_postnatal_growth/wei0.74695804
135MP0002653_abnormal_ependyma_morphology0.74580201
136MP0003385_abnormal_body_wall0.74178106
137MP0001663_abnormal_digestive_system0.73718608
138MP0000604_amyloidosis0.73278286
139MP0005410_abnormal_fertilization0.66914344
140* MP0002132_abnormal_respiratory_system0.65593947
141MP0009763_increased_sensitivity_to0.63103836
142MP0005666_abnormal_adipose_tissue0.61930672

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)4.74576099
2Recurrent bacterial skin infections (HP:0005406)4.66875545
3Orchitis (HP:0100796)4.54859246
4Retrobulbar optic neuritis (HP:0100654)3.99461170
5Optic neuritis (HP:0100653)3.99461170
6Protrusio acetabuli (HP:0003179)3.95458175
7Elevated erythrocyte sedimentation rate (HP:0003565)3.89077179
8Cerebral aneurysm (HP:0004944)3.68230881
9Gastrointestinal infarctions (HP:0005244)3.59297246
10Stomatitis (HP:0010280)3.54070521
11Chronic obstructive pulmonary disease (HP:0006510)3.49001897
12Obstructive lung disease (HP:0006536)3.49001897
13Increased IgE level (HP:0003212)3.40896035
14Meningitis (HP:0001287)3.27393623
15Recurrent skin infections (HP:0001581)3.02985088
16Shallow orbits (HP:0000586)2.99958076
17Short 4th metacarpal (HP:0010044)2.94308659
18Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.94308659
19Keratoconjunctivitis sicca (HP:0001097)2.88738815
20Prolonged bleeding time (HP:0003010)2.88430926
21Ankle contracture (HP:0006466)2.85807979
22Abnormal delayed hypersensitivity skin test (HP:0002963)2.83318758
23Vasculitis (HP:0002633)2.83158907
24Pustule (HP:0200039)2.80631578
25Urticaria (HP:0001025)2.79847170
26Chest pain (HP:0100749)2.76274183
27Hypochromic anemia (HP:0001931)2.75435758
28Eczematoid dermatitis (HP:0000976)2.73907170
29Peritonitis (HP:0002586)2.73841459
30Amyloidosis (HP:0011034)2.71993853
31Alopecia of scalp (HP:0002293)2.70996025
32Hypochromic microcytic anemia (HP:0004840)2.68770381
33Ulnar bowing (HP:0003031)2.65613133
34Encephalitis (HP:0002383)2.63706516
35Premature rupture of membranes (HP:0001788)2.63450333
36Keratoconjunctivitis (HP:0001096)2.54965885
37Increased density of long bones (HP:0006392)2.54058693
38Recurrent cutaneous fungal infections (HP:0011370)2.53151740
39Chronic mucocutaneous candidiasis (HP:0002728)2.53151740
40Mitral valve prolapse (HP:0001634)2.51788224
41Aortic aneurysm (HP:0004942)2.51031388
42Episodic fever (HP:0001954)2.45533309
43Hemoptysis (HP:0002105)2.42132945
44Epistaxis (HP:0000421)2.40141511
45Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39098369
46Gingival bleeding (HP:0000225)2.38246587
47Genu recurvatum (HP:0002816)2.37171810
48Arterial thrombosis (HP:0004420)2.37143426
49Pulmonary infiltrates (HP:0002113)2.35642247
50Aortic dissection (HP:0002647)2.35627128
51Selective tooth agenesis (HP:0001592)2.35457560
52Increased cerebral lipofuscin (HP:0011813)2.32193238
53Myocardial infarction (HP:0001658)2.31212663
54Increased connective tissue (HP:0009025)2.31099338
55Abnormality of the 4th metacarpal (HP:0010012)2.25948118
56Loss of speech (HP:0002371)2.21080972
57Asymmetric septal hypertrophy (HP:0001670)2.20149229
58Interstitial pulmonary disease (HP:0006530)2.19924195
59Segmental peripheral demyelination/remyelination (HP:0003481)2.19041968
60Dilatation of the ascending aorta (HP:0005111)2.18514696
61Purpura (HP:0000979)2.16244983
62Petechiae (HP:0000967)2.14462978
63Pulmonary embolism (HP:0002204)2.14041564
64Osteomyelitis (HP:0002754)2.10733534
65Spontaneous hematomas (HP:0007420)2.09695042
66Dysostosis multiplex (HP:0000943)2.09579465
67Slow saccadic eye movements (HP:0000514)2.07890921
68Aneurysm (HP:0002617)2.07462230
69Recurrent viral infections (HP:0004429)2.05725775
70Recurrent fungal infections (HP:0002841)2.03232303
71Distal lower limb muscle weakness (HP:0009053)2.03168652
72Abnormality of the peritoneum (HP:0002585)2.01709501
73Anorexia (HP:0002039)2.01618518
74Spinal cord lesions (HP:0100561)2.00913981
75Syringomyelia (HP:0003396)2.00913981
76Hemorrhage of the eye (HP:0011885)1.98344720
77Leukocytosis (HP:0001974)1.98178474
78Atrophic scars (HP:0001075)1.97977599
79Metaphyseal cupping (HP:0003021)1.97342174
80Basal cell carcinoma (HP:0002671)1.97331700
81Rib fusion (HP:0000902)1.96871887
82Sepsis (HP:0100806)1.96858211
83Broad face (HP:0000283)1.96809693
84Blue sclerae (HP:0000592)1.96723957
85Abnormality of the fingertips (HP:0001211)1.96630149
86Increased serum ferritin (HP:0003281)1.96536541
87Obstructive sleep apnea (HP:0002870)1.96378511
88Rectal prolapse (HP:0002035)1.95076971
89Increased neuronal autofluorescent lipopigment (HP:0002074)1.93725877
90Broad metatarsal (HP:0001783)1.93691588
91Disproportionate tall stature (HP:0001519)1.90786917
92Slender build (HP:0001533)1.89402596
93Hypergammaglobulinemia (HP:0010702)1.87438515
94Abnormality of liposaccharide metabolism (HP:0010968)1.87191201
95Abnormality of glycosphingolipid metabolism (HP:0004343)1.87191201
96Abnormality of glycolipid metabolism (HP:0010969)1.87191201
97Microcytic anemia (HP:0001935)1.86235969
98Abnormality of the endocardium (HP:0004306)1.85741035
99Abnormality of the nasal mucosa (HP:0000433)1.85129226
100Granulocytopenia (HP:0001913)1.84956601
101Cervical subluxation (HP:0003308)1.84940461
102Glomerulopathy (HP:0100820)1.84260490
103Renal duplication (HP:0000075)1.83862248
104Abnormality of the pleura (HP:0002103)1.83858396
105Hypertriglyceridemia (HP:0002155)1.83854921
106Type 1 muscle fiber predominance (HP:0003803)1.83592607
107Acne (HP:0001061)1.83046165
108Wrist flexion contracture (HP:0001239)1.82933797
109Premature loss of primary teeth (HP:0006323)1.82743165
110Easy fatigability (HP:0003388)1.81674585
111Increased IgM level (HP:0003496)1.81496491
112Cellulitis (HP:0100658)1.81426844
113Bladder diverticulum (HP:0000015)1.81377100
114Recurrent gram-negative bacterial infections (HP:0005420)1.80200575
115Osteolytic defects of the hand bones (HP:0009699)1.79797828
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.79797828
117Abnormality of polysaccharide metabolism (HP:0011012)1.79049175
118Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79049175
119Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79049175
120Skin ulcer (HP:0200042)1.78252262
121Gastrointestinal stroma tumor (HP:0100723)1.77901717
122Hyperacusis (HP:0010780)1.77466217
123Supernumerary ribs (HP:0005815)1.77347048
124Emphysema (HP:0002097)1.76957508
125Restrictive lung disease (HP:0002091)1.76473451
126Hematochezia (HP:0002573)1.73637509
127Nasal polyposis (HP:0100582)1.73222035
128Milia (HP:0001056)1.72983976
129Fragile skin (HP:0001030)1.71159982
130Bowing of the arm (HP:0006488)1.70547405
131Bowed forearm bones (HP:0003956)1.70547405
132Recurrent abscess formation (HP:0002722)1.70188762
133Esophageal varix (HP:0002040)1.69718525
134Cheilitis (HP:0100825)1.69692057
135Long eyelashes (HP:0000527)1.69386515
136Periodontitis (HP:0000704)1.69204492
137Abnormal platelet volume (HP:0011876)1.68986260
138Myositis (HP:0100614)1.68408645
139Colitis (HP:0002583)1.67345147
140Bicuspid aortic valve (HP:0001647)1.66942854
141Broad toe (HP:0001837)1.66907744
142Hand muscle atrophy (HP:0009130)1.65562711
143Broad thumb (HP:0011304)1.65123087
144Bilateral sensorineural hearing impairment (HP:0008619)1.64729699
145Vertebral fusion (HP:0002948)1.64542334
146Gastrointestinal inflammation (HP:0004386)1.64378764
147Polycythemia (HP:0001901)1.63497514
148Broad palm (HP:0001169)1.63138543
149Camptodactyly of toe (HP:0001836)1.62687603
150Broad hallux (HP:0010055)1.61320332
151Lymphangioma (HP:0100764)1.61258903
152Gingivitis (HP:0000230)1.59495590
153Persistence of primary teeth (HP:0006335)1.59115613
154Spinal rigidity (HP:0003306)1.58387285
155Vertebral compression fractures (HP:0002953)1.58085854
156Thin bony cortex (HP:0002753)1.57778651
157Inflammation of the large intestine (HP:0002037)1.57738252
158Mediastinal lymphadenopathy (HP:0100721)1.56061650
159Short 5th finger (HP:0009237)1.55981839
160Increased mean platelet volume (HP:0011877)1.55916485
161Intestinal fistula (HP:0100819)1.55538009
162Short humerus (HP:0005792)1.55220850
163Turricephaly (HP:0000262)1.55052264
164IgM deficiency (HP:0002850)1.54905778
165Annular pancreas (HP:0001734)1.54670137
166Biconcave vertebral bodies (HP:0004586)1.54435254
167Follicular hyperkeratosis (HP:0007502)1.54194442
168Mildly elevated creatine phosphokinase (HP:0008180)1.54188468
169Spondylolisthesis (HP:0003302)1.54162832
170Urethral obstruction (HP:0000796)1.54001274
171Dislocated radial head (HP:0003083)1.53402087
172Skin tags (HP:0010609)1.53034197
173Distal upper limb amyotrophy (HP:0007149)1.53014088
174Upper limb amyotrophy (HP:0009129)1.53014088
175Inguinal hernia (HP:0000023)1.52502545
176Abnormality of the distal phalanx of the thumb (HP:0009617)1.51743575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.66874651
2TRIB33.40898450
3CDK123.31730967
4MAP3K103.25519922
5MAP4K13.19878999
6PRPF4B2.84717494
7ERN12.80581892
8PKN22.56670828
9IRAK42.42570678
10EEF2K2.37021239
11STK102.30162104
12ICK2.12593299
13SIK12.06663688
14TNK22.06339780
15SMG11.74757214
16BMX1.72602698
17CSK1.72460150
18FES1.72106365
19RIPK11.67542503
20MAP3K111.65741574
21DDR21.62710480
22PDGFRA1.56942306
23TTN1.51455791
24FGFR41.46753482
25GRK61.46139941
26PIM11.44983299
27MAP3K131.44365600
28TGFBR21.44197256
29EPHB11.43680582
30PTK61.43424569
31FLT31.40822304
32KSR21.39090240
33MAP3K11.35463848
34LRRK21.34350442
35JAK31.33918786
36MARK21.32062519
37PAK41.30710944
38ZAP701.28700323
39CDK61.26128639
40RPS6KA41.24337850
41LATS11.16045350
42PIM21.14344476
43TESK11.14287109
44IKBKE1.14025993
45PDPK11.12920890
46EPHA21.11128673
47DMPK1.10786057
48MTOR1.09574370
49PRKD21.07956119
50CHUK1.06298460
51DYRK1B1.05583734
52TYK21.05563837
53MAP2K31.05247586
54PTK21.04278643
55SYK0.99375155
56NEK20.98759210
57IRAK30.98385048
58PDK10.98005227
59CDK40.94193152
60EPHA30.92660501
61CDC42BPA0.92037656
62STK380.91681688
63BTK0.91188878
64BLK0.91164014
65TXK0.89593356
66KDR0.89205086
67EPHB20.88487489
68LYN0.86729316
69BRD40.86085980
70FGR0.85876608
71ITK0.85638351
72TBK10.83175833
73LATS20.82639507
74FGFR10.82063478
75TYRO30.81341452
76* CDK70.80258542
77FGFR30.80163634
78HCK0.79931790
79MAPK150.79469533
80MARK30.77501619
81ALK0.76600443
82MAP3K30.75672733
83TESK20.73070795
84IKBKB0.72905639
85IRAK20.72804232
86CAMK1D0.72488830
87MATK0.72428513
88RPS6KA20.71985775
89CSF1R0.71926508
90STK30.71143517
91RPS6KB20.71058389
92KIT0.70767675
93YES10.70684870
94RPS6KL10.70347581
95RPS6KC10.70347581
96MAP3K70.69964912
97TAOK10.69522979
98MAP3K80.69517997
99MAPK120.69265582
100MAPK70.68848998
101PDGFRB0.68443296
102PAK20.68180317
103RPS6KA60.67220311
104JAK10.67050021
105TRPM70.66972061
106SIK30.64963408
107RET0.62919504
108IRAK10.61662634
109SIK20.60419817
110PRKG20.59751577
111MAP2K20.59400422
112CDK90.59012873
113MAP3K60.58830796
114CLK10.57610607
115RPS6KA10.57090131
116TGFBR10.56164399
117MAP3K20.55667683
118LCK0.53966950
119GSK3A0.51279762
120FYN0.50513058
121MAPK110.50167500
122JAK20.49506207
123MAPKAPK20.47095453
124CAMKK10.46017295
125SGK30.45339913
126TAOK20.45111087
127MAP3K140.44819195
128STK40.43911493
129PTK2B0.43710741
130EGFR0.43096229
131PIK3CG0.42674834
132TLK10.41617532
133NLK0.40856259
134HIPK20.40260999
135PRKD10.38933468
136* MAPK10.38406650
137TAOK30.35239355

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07390196
2Adherens junction_Homo sapiens_hsa045201.79445374
3Staphylococcus aureus infection_Homo sapiens_hsa051501.79081464
4Notch signaling pathway_Homo sapiens_hsa043301.77877738
5Chronic myeloid leukemia_Homo sapiens_hsa052201.75260273
6Graft-versus-host disease_Homo sapiens_hsa053321.74986703
7Allograft rejection_Homo sapiens_hsa053301.71644971
8Other glycan degradation_Homo sapiens_hsa005111.71491089
9Leishmaniasis_Homo sapiens_hsa051401.70423523
10Primary immunodeficiency_Homo sapiens_hsa053401.70278566
11Viral myocarditis_Homo sapiens_hsa054161.62805764
12Autoimmune thyroid disease_Homo sapiens_hsa053201.59508792
13Lysine degradation_Homo sapiens_hsa003101.56846281
14Small cell lung cancer_Homo sapiens_hsa052221.50528274
15* Acute myeloid leukemia_Homo sapiens_hsa052211.48239458
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.46408812
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.45518993
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.44654706
19Bladder cancer_Homo sapiens_hsa052191.43140894
20Basal cell carcinoma_Homo sapiens_hsa052171.41648338
21Osteoclast differentiation_Homo sapiens_hsa043801.40704635
22MicroRNAs in cancer_Homo sapiens_hsa052061.40690287
23B cell receptor signaling pathway_Homo sapiens_hsa046621.40364864
24AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.39240285
25Proteoglycans in cancer_Homo sapiens_hsa052051.37021190
26Shigellosis_Homo sapiens_hsa051311.36443438
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.35348671
28Toxoplasmosis_Homo sapiens_hsa051451.32600340
29Measles_Homo sapiens_hsa051621.28999183
30HTLV-I infection_Homo sapiens_hsa051661.26941278
31Focal adhesion_Homo sapiens_hsa045101.23998169
32Herpes simplex infection_Homo sapiens_hsa051681.23172625
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.22947901
34One carbon pool by folate_Homo sapiens_hsa006701.20401544
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20151058
36TGF-beta signaling pathway_Homo sapiens_hsa043501.20075407
37Pancreatic cancer_Homo sapiens_hsa052121.18084391
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17988158
39T cell receptor signaling pathway_Homo sapiens_hsa046601.17888132
40Base excision repair_Homo sapiens_hsa034101.17710174
41Hippo signaling pathway_Homo sapiens_hsa043901.17239560
42Hepatitis C_Homo sapiens_hsa051601.16532128
43Type I diabetes mellitus_Homo sapiens_hsa049401.16386570
44* Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15535134
45Hepatitis B_Homo sapiens_hsa051611.13790506
46mTOR signaling pathway_Homo sapiens_hsa041501.13390964
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12817247
48Antigen processing and presentation_Homo sapiens_hsa046121.10732725
49Phagosome_Homo sapiens_hsa041451.10500508
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.09978659
51Colorectal cancer_Homo sapiens_hsa052101.08551979
52Legionellosis_Homo sapiens_hsa051341.08499560
53p53 signaling pathway_Homo sapiens_hsa041151.07208396
54Viral carcinogenesis_Homo sapiens_hsa052031.06927465
55Apoptosis_Homo sapiens_hsa042101.04137189
56TNF signaling pathway_Homo sapiens_hsa046681.03366121
57Amoebiasis_Homo sapiens_hsa051461.02805107
58Malaria_Homo sapiens_hsa051441.02522433
59Endocytosis_Homo sapiens_hsa041440.99696316
60ECM-receptor interaction_Homo sapiens_hsa045120.99003815
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.95839244
62Complement and coagulation cascades_Homo sapiens_hsa046100.95261808
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94295135
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94258962
65VEGF signaling pathway_Homo sapiens_hsa043700.93989824
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92152255
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.91680354
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.91338123
69Mismatch repair_Homo sapiens_hsa034300.90820671
70Hematopoietic cell lineage_Homo sapiens_hsa046400.90486842
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89930360
72Lysosome_Homo sapiens_hsa041420.88901445
73Hedgehog signaling pathway_Homo sapiens_hsa043400.88080206
74Insulin resistance_Homo sapiens_hsa049310.88079598
75African trypanosomiasis_Homo sapiens_hsa051430.86926029
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83755582
77* Pathways in cancer_Homo sapiens_hsa052000.83687346
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.83230338
79Choline metabolism in cancer_Homo sapiens_hsa052310.82646065
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.82386511
81Endometrial cancer_Homo sapiens_hsa052130.80035883
82Spliceosome_Homo sapiens_hsa030400.79210642
83Prostate cancer_Homo sapiens_hsa052150.79086491
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77922976
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.77922459
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77614097
87Influenza A_Homo sapiens_hsa051640.76657702
88HIF-1 signaling pathway_Homo sapiens_hsa040660.74706534
89GnRH signaling pathway_Homo sapiens_hsa049120.74479601
90Thyroid cancer_Homo sapiens_hsa052160.73889708
91DNA replication_Homo sapiens_hsa030300.73499590
92ErbB signaling pathway_Homo sapiens_hsa040120.73113922
93RNA transport_Homo sapiens_hsa030130.72664348
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72483381
95Non-small cell lung cancer_Homo sapiens_hsa052230.72459569
96Tuberculosis_Homo sapiens_hsa051520.70783220
97Platelet activation_Homo sapiens_hsa046110.70533934
98Inositol phosphate metabolism_Homo sapiens_hsa005620.70340929
99Insulin signaling pathway_Homo sapiens_hsa049100.69827205
100Sulfur relay system_Homo sapiens_hsa041220.69406157
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.69298695
102Estrogen signaling pathway_Homo sapiens_hsa049150.69086808
103mRNA surveillance pathway_Homo sapiens_hsa030150.68296512
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68255510
105Cell cycle_Homo sapiens_hsa041100.67747774
106Epstein-Barr virus infection_Homo sapiens_hsa051690.67446811
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66781375
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66677623
109Arginine biosynthesis_Homo sapiens_hsa002200.65954964
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64968741
111Chemokine signaling pathway_Homo sapiens_hsa040620.64886735
112Prolactin signaling pathway_Homo sapiens_hsa049170.64744195
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63880984
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63629785
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.62642768
116Caffeine metabolism_Homo sapiens_hsa002320.61268691
117MAPK signaling pathway_Homo sapiens_hsa040100.61236537
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60289900
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60277983
120Type II diabetes mellitus_Homo sapiens_hsa049300.59508893
121Renal cell carcinoma_Homo sapiens_hsa052110.58980528
122Dorso-ventral axis formation_Homo sapiens_hsa043200.58826387
123Biosynthesis of amino acids_Homo sapiens_hsa012300.58504692
124Salmonella infection_Homo sapiens_hsa051320.58366360
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.57993365
126Rheumatoid arthritis_Homo sapiens_hsa053230.57923969
127FoxO signaling pathway_Homo sapiens_hsa040680.57448313
128Glioma_Homo sapiens_hsa052140.57335707
129Selenocompound metabolism_Homo sapiens_hsa004500.55823538
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55253264
131Pertussis_Homo sapiens_hsa051330.54153933
132Wnt signaling pathway_Homo sapiens_hsa043100.53448962
133Rap1 signaling pathway_Homo sapiens_hsa040150.52067079
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51916978
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50027837

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