RAPGEFL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)7.67574392
2establishment of skin barrier (GO:0061436)7.06876652
3regulation of water loss via skin (GO:0033561)6.58467161
4regulation of short-term neuronal synaptic plasticity (GO:0048172)6.51023326
5synaptic vesicle maturation (GO:0016188)6.33430700
6locomotory exploration behavior (GO:0035641)6.27914308
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.17426837
8keratinization (GO:0031424)5.99748375
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.87731735
10vocalization behavior (GO:0071625)5.84494005
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.69519529
12glutamate secretion (GO:0014047)5.59984076
13synaptic vesicle exocytosis (GO:0016079)5.49961014
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.36778803
15regulation of glutamate receptor signaling pathway (GO:1900449)5.34239968
16multicellular organismal water homeostasis (GO:0050891)5.31644306
17regulation of synaptic vesicle exocytosis (GO:2000300)5.08217682
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.97298299
19protein localization to synapse (GO:0035418)4.85456269
20regulation of neuronal synaptic plasticity (GO:0048168)4.84447760
21exploration behavior (GO:0035640)4.83206717
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69145299
23regulation of synaptic vesicle transport (GO:1902803)4.56802974
24bundle of His cell to Purkinje myocyte communication (GO:0086069)4.53307656
25regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.52996840
26neuronal action potential propagation (GO:0019227)4.47277849
27synaptic transmission, glutamatergic (GO:0035249)4.45565221
28dendritic spine morphogenesis (GO:0060997)4.44811443
29neurotransmitter-gated ion channel clustering (GO:0072578)4.37118400
30water homeostasis (GO:0030104)4.33994820
31glutamate receptor signaling pathway (GO:0007215)4.33146092
32neurotransmitter secretion (GO:0007269)4.30254504
33cytoskeletal anchoring at plasma membrane (GO:0007016)4.22356762
34regulation of synapse structural plasticity (GO:0051823)4.19593970
35long-term memory (GO:0007616)4.18191222
36neuron cell-cell adhesion (GO:0007158)4.11317966
37positive regulation of membrane potential (GO:0045838)4.05771611
38layer formation in cerebral cortex (GO:0021819)4.04266102
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.01556383
40neuron-neuron synaptic transmission (GO:0007270)3.96476061
41positive regulation of synapse maturation (GO:0090129)3.93033948
42regulation of synaptic plasticity (GO:0048167)3.92045510
43proline transport (GO:0015824)3.89838606
44regulation of dendritic spine morphogenesis (GO:0061001)3.85514118
45cellular potassium ion homeostasis (GO:0030007)3.84905813
46regulation of postsynaptic membrane potential (GO:0060078)3.77355715
47cell communication involved in cardiac conduction (GO:0086065)3.74901683
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71189930
49dendritic spine organization (GO:0097061)3.67213457
50intermediate filament organization (GO:0045109)3.65411906
51keratinocyte differentiation (GO:0030216)3.65313239
52keratinocyte proliferation (GO:0043616)3.62217249
53long-term synaptic potentiation (GO:0060291)3.60301102
54sodium ion export (GO:0071436)3.60222171
55synaptic vesicle endocytosis (GO:0048488)3.55728226
56regulation of neurotransmitter secretion (GO:0046928)3.49992716
57positive regulation of neurotransmitter secretion (GO:0001956)3.49336091
58G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.47616412
59postsynaptic membrane organization (GO:0001941)3.44095764
60gamma-aminobutyric acid transport (GO:0015812)3.43177913
61chemosensory behavior (GO:0007635)3.42706414
62regulation of vesicle fusion (GO:0031338)3.41463551
63peptidyl-tyrosine autophosphorylation (GO:0038083)3.39795170
64neurotransmitter transport (GO:0006836)3.39076883
65negative regulation of keratinocyte proliferation (GO:0010839)3.38852789
66neuromuscular process controlling balance (GO:0050885)3.35641249
67activation of protein kinase A activity (GO:0034199)3.35147952
68amino acid import (GO:0043090)3.34856966
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33759123
70regulation of dendritic spine development (GO:0060998)3.32835272
71neuron recognition (GO:0008038)3.29961267
72central nervous system myelination (GO:0022010)3.29723649
73axon ensheathment in central nervous system (GO:0032291)3.29723649
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.28946829
75cerebellar Purkinje cell differentiation (GO:0021702)3.26934710
76L-amino acid import (GO:0043092)3.25468421
77innervation (GO:0060384)3.24680015
78cerebellar granule cell differentiation (GO:0021707)3.21543923
79positive regulation of neurotransmitter transport (GO:0051590)3.20789324
80negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18857204
81regulation of neurotransmitter transport (GO:0051588)3.18120862
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.17776903
83axonal fasciculation (GO:0007413)3.17451559
84positive regulation of synaptic transmission, GABAergic (GO:0032230)3.17365418
85cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13734914
86epidermal cell differentiation (GO:0009913)3.13598744
87regulation of neurotransmitter levels (GO:0001505)3.13321830
88hemidesmosome assembly (GO:0031581)3.13059474
89positive regulation of dendritic spine morphogenesis (GO:0061003)3.12592643
90membrane depolarization (GO:0051899)3.12280471
91behavioral fear response (GO:0001662)3.12109029
92behavioral defense response (GO:0002209)3.12109029
93dendrite morphogenesis (GO:0048813)3.12079139
94positive regulation of dendritic spine development (GO:0060999)3.11955464
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.10538224
96transmission of nerve impulse (GO:0019226)3.10133647
97cardiac conduction (GO:0061337)3.09706997
98auditory behavior (GO:0031223)3.09599439
99regulation of synaptic transmission (GO:0050804)3.08752920
100potassium ion homeostasis (GO:0055075)3.07523734
101positive regulation of synaptic transmission (GO:0050806)3.06828627
102regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.06505647
103sodium ion homeostasis (GO:0055078)3.05674387
104regulation of ARF protein signal transduction (GO:0032012)3.05287171
105learning (GO:0007612)3.04899528
106regulation of heart rate by cardiac conduction (GO:0086091)3.04698662
107presynaptic membrane assembly (GO:0097105)3.02492982
108cell communication by electrical coupling (GO:0010644)3.02339490
109regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.01889796
110long term synaptic depression (GO:0060292)3.01726929
111positive regulation of vesicle fusion (GO:0031340)3.00160287
112social behavior (GO:0035176)3.00016366
113intraspecies interaction between organisms (GO:0051703)3.00016366
114negative regulation of dendrite morphogenesis (GO:0050774)2.99720649
115regulation of synapse maturation (GO:0090128)2.99445900
116response to auditory stimulus (GO:0010996)2.98805754
117vesicle transport along microtubule (GO:0047496)2.97953791
118neuronal ion channel clustering (GO:0045161)2.96915206
119glycine transport (GO:0015816)2.96358773
120response to histamine (GO:0034776)2.91050388
121membrane depolarization during action potential (GO:0086010)2.90972562
122regulation of cholesterol homeostasis (GO:2000188)2.90624866
123regulation of clathrin-mediated endocytosis (GO:2000369)2.90620324
124cellular sodium ion homeostasis (GO:0006883)2.90564802
125synaptic transmission (GO:0007268)2.89272500
126fear response (GO:0042596)2.89268653
127neuromuscular process controlling posture (GO:0050884)2.88503612
128regulation of guanylate cyclase activity (GO:0031282)2.87755144
129peptide cross-linking (GO:0018149)2.84968824
130ventricular cardiac muscle cell action potential (GO:0086005)2.81766849
131epidermis development (GO:0008544)2.79171927
132maintenance of gastrointestinal epithelium (GO:0030277)2.76922085
133hair cycle (GO:0042633)2.75752562
134molting cycle (GO:0042303)2.75752562
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.72363799
136regulation of female receptivity (GO:0045924)2.70139434
137cell-cell junction maintenance (GO:0045217)2.69935105
138dopamine receptor signaling pathway (GO:0007212)2.69755100
139long-chain fatty acid biosynthetic process (GO:0042759)2.67940945
140potassium ion import (GO:0010107)2.65092210
141renal system process involved in regulation of blood volume (GO:0001977)2.61977166
142phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.61430647
143apical protein localization (GO:0045176)2.53878328
144cochlea development (GO:0090102)2.52702633
145positive regulation of keratinocyte differentiation (GO:0045618)2.50539851
146positive regulation of epidermal cell differentiation (GO:0045606)2.50025031
147phosphatidylserine acyl-chain remodeling (GO:0036150)2.47173596
148activation of Rac GTPase activity (GO:0032863)2.45997079
149NADH metabolic process (GO:0006734)2.45730125
150regulation of voltage-gated calcium channel activity (GO:1901385)2.45274058
151myelin maintenance (GO:0043217)2.41213757
152cell migration in hindbrain (GO:0021535)2.35949035
153angiotensin maturation (GO:0002003)2.35245603
154regulation of keratinocyte differentiation (GO:0045616)2.32569522
155mating behavior (GO:0007617)2.30747420
156negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.30312664

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.92821178
2EZH2_22144423_ChIP-Seq_EOC_Human5.82496849
3* ESR2_21235772_ChIP-Seq_MCF-7_Human3.13484993
4GBX2_23144817_ChIP-Seq_PC3_Human3.13241836
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07533068
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03416775
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95197630
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.77430400
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.74590679
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.74590679
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69041679
12DROSHA_22980978_ChIP-Seq_HELA_Human2.63565654
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60525015
14* ESR1_21235772_ChIP-Seq_MCF-7_Human2.56861154
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53248244
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.52837425
17REST_21632747_ChIP-Seq_MESCs_Mouse2.52390147
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.50642906
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48162089
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47437703
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38724166
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33703293
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30606547
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.29179462
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.28967809
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.26315584
27LXR_22292898_ChIP-Seq_THP-1_Human2.22579282
28* RACK7_27058665_Chip-Seq_MCF-7_Human2.11356443
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08539801
30* ESR1_20079471_ChIP-ChIP_T-47D_Human2.07166930
31CDX2_20551321_ChIP-Seq_CACO-2_Human2.03214980
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.00732622
33AR_21572438_ChIP-Seq_LNCaP_Human1.94360294
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94341180
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.88923413
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85881704
37* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.78257402
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.72009138
39CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70149018
40ZNF263_19887448_ChIP-Seq_K562_Human1.70104907
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60759080
42SMC4_20622854_ChIP-Seq_HELA_Human1.57558431
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56061628
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56004373
45SOX2_27498859_Chip-Seq_STOMACH_Mouse1.55587633
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55251030
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.55052202
48CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.50957932
49SMAD4_21799915_ChIP-Seq_A2780_Human1.49896261
50TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49653316
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48051792
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45404129
53* CREB1_26743006_Chip-Seq_LNCaP_Human1.44827394
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.43317194
55UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41444992
56TP63_22573176_ChIP-Seq_HFKS_Human1.41398902
57CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40691946
58SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39452171
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.38740560
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.33310806
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.32363095
62P68_20966046_ChIP-Seq_HELA_Human1.32085616
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30767095
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30384142
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30320939
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.29657298
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.28684238
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.27577445
69SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27170181
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25812479
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24489830
72KLF5_25053715_ChIP-Seq_YYC3_Human1.24217595
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.23641457
74AR_25329375_ChIP-Seq_VCAP_Human1.23618355
75WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23270001
76* SA1_27219007_Chip-Seq_ERYTHROID_Human1.23061667
77* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.21673639
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.21478329
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20925363
80SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20800346
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20481507
82* KDM2B_26808549_Chip-Seq_K562_Human1.17013592
83RXR_22108803_ChIP-Seq_LS180_Human1.16728182
84P300_19829295_ChIP-Seq_ESCs_Human1.16634238
85AR_19668381_ChIP-Seq_PC3_Human1.16588881
86ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16399134
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.16028283
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15850461
89KDM2B_26808549_Chip-Seq_DND41_Human1.15782785
90CBX2_27304074_Chip-Seq_ESCs_Mouse1.15343322
91SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14881366
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13569017
93SA1_27219007_Chip-Seq_Bcells_Human1.13467722
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13305738
95TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12942737
96NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12812029
97* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12752824
98ARNT_22903824_ChIP-Seq_MCF-7_Human1.12313544
99TAF15_26573619_Chip-Seq_HEK293_Human1.11598433
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.11115677
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11023753
102SOX2_20726797_ChIP-Seq_SW620_Human1.10236663
103P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10173446
104TCF7_22412390_ChIP-Seq_EML_Mouse1.09831876
105TET1_21451524_ChIP-Seq_MESCs_Mouse1.09829894
106AHR_22903824_ChIP-Seq_MCF-7_Human1.09181927
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08984164
108KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08411277
109STAT3_23295773_ChIP-Seq_U87_Human1.08330132
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07920734
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07270733
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.05548829
113SMAD3_21741376_ChIP-Seq_HESCs_Human1.05060128
114TP53_16413492_ChIP-PET_HCT116_Human1.04940295
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04748183
116* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04151537
117ZNF274_21170338_ChIP-Seq_K562_Hela1.03486268
118ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02853385
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01917961
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01892660
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01749270
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00692294
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00200200
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99850997
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99706869
126* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99587328
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97959224
128PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97797315
129BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97586935
130* GATA6_25053715_ChIP-Seq_YYC3_Human0.96709394
131* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96147373
132* FOXO3_23340844_ChIP-Seq_DLD1_Human0.95963028
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.95731579
134TCF4_23295773_ChIP-Seq_U87_Human0.95305578
135CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94453404
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93934458
137BCOR_27268052_Chip-Seq_Bcells_Human0.93662733
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.93228180
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93209575
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92946396
141CTCF_27219007_Chip-Seq_Bcells_Human0.92877646
142RNF2_27304074_Chip-Seq_NSC_Mouse0.92288391
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.92130139
144SMAD4_21741376_ChIP-Seq_HESCs_Human0.91976504
145TP53_18474530_ChIP-ChIP_U2OS_Human0.91427327
146P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91343726
147MYC_27129775_Chip-Seq_CORNEA_Mouse0.90186977
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89762301
149NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87748814
150ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83871158
151RUNX2_22187159_ChIP-Seq_PCA_Human0.83842594
152TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83481404
153TP53_20018659_ChIP-ChIP_R1E_Mouse0.83443474
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83258558
155BCAT_22108803_ChIP-Seq_LS180_Human0.83226690
156SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83074899
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82986641
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82986641
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.82941448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.81407233
2MP0003880_abnormal_central_pattern4.82821635
3MP0003635_abnormal_synaptic_transmissio4.34849072
4MP0004270_analgesia3.89091739
5MP0000566_synostosis3.64821116
6MP0002063_abnormal_learning/memory/cond3.48397147
7MP0009745_abnormal_behavioral_response3.43398887
8MP0004264_abnormal_extraembryonic_tissu3.34654554
9MP0009379_abnormal_foot_pigmentation3.18654676
10MP0002064_seizures3.16201946
11MP0009046_muscle_twitch2.87615652
12MP0002572_abnormal_emotion/affect_behav2.81535266
13MP0001968_abnormal_touch/_nociception2.79852831
14MP0001486_abnormal_startle_reflex2.55840463
15MP0005423_abnormal_somatic_nervous2.55402583
16MP0002734_abnormal_mechanical_nocicepti2.50436773
17MP0002272_abnormal_nervous_system2.43206176
18MP0002822_catalepsy2.39100852
19MP0002098_abnormal_vibrissa_morphology2.37101359
20MP0003705_abnormal_hypodermis_morpholog2.36771733
21MP0001501_abnormal_sleep_pattern2.33744752
22MP0009780_abnormal_chondrocyte_physiolo2.24649663
23MP0002736_abnormal_nociception_after2.09527807
24MP0001440_abnormal_grooming_behavior2.03248181
25MP0002735_abnormal_chemical_nociception2.03153493
26MP0008569_lethality_at_weaning2.00379144
27MP0003183_abnormal_peptide_metabolism1.99633644
28MP0003453_abnormal_keratinocyte_physiol1.97585017
29MP0003879_abnormal_hair_cell1.94145015
30MP0004858_abnormal_nervous_system1.83049204
31MP0010234_abnormal_vibrissa_follicle1.77923573
32MP0004043_abnormal_pH_regulation1.75538015
33MP0001970_abnormal_pain_threshold1.74365298
34MP0002067_abnormal_sensory_capabilities1.73778058
35MP0004811_abnormal_neuron_physiology1.73412282
36MP0001216_abnormal_epidermal_layer1.70234171
37MP0002733_abnormal_thermal_nociception1.69431941
38MP0000778_abnormal_nervous_system1.69038455
39MP0002557_abnormal_social/conspecific_i1.68197886
40MP0003787_abnormal_imprinting1.68101841
41MP0002184_abnormal_innervation1.63963110
42MP0000678_abnormal_parathyroid_gland1.63766936
43MP0003191_abnormal_cellular_cholesterol1.63661974
44MP0005646_abnormal_pituitary_gland1.60817178
45MP0003329_amyloid_beta_deposits1.59353551
46MP0004885_abnormal_endolymph1.59125872
47MP0000383_abnormal_hair_follicle1.57542150
48MP0000377_abnormal_hair_follicle1.52282613
49MP0002796_impaired_skin_barrier1.51835811
50MP0004782_abnormal_surfactant_physiolog1.51054931
51MP0002249_abnormal_larynx_morphology1.50923371
52MP0002909_abnormal_adrenal_gland1.46171250
53MP0000955_abnormal_spinal_cord1.42367569
54MP0005386_behavior/neurological_phenoty1.40412856
55MP0004924_abnormal_behavior1.40412856
56MP0003941_abnormal_skin_development1.34106121
57MP0002882_abnormal_neuron_morphology1.31372252
58MP0001984_abnormal_olfaction1.31199355
59MP0002066_abnormal_motor_capabilities/c1.29599654
60MP0003633_abnormal_nervous_system1.27179424
61MP0004381_abnormal_hair_follicle1.25094872
62MP0001666_abnormal_nutrient_absorption1.23547801
63MP0005645_abnormal_hypothalamus_physiol1.23378583
64MP0004019_abnormal_vitamin_homeostasis1.22355202
65MP0004947_skin_inflammation1.20422604
66MP0001188_hyperpigmentation1.19927139
67MP0000579_abnormal_nail_morphology1.19382877
68MP0001502_abnormal_circadian_rhythm1.16691853
69MP0001765_abnormal_ion_homeostasis1.16234319
70MP0003075_altered_response_to1.14019973
71MP0005360_urolithiasis1.12902601
72MP0002060_abnormal_skin_morphology1.08529154
73MP0003631_nervous_system_phenotype1.05299654
74MP0000762_abnormal_tongue_morphology1.01548899
75MP0008961_abnormal_basal_metabolism1.01223150
76MP0005377_hearing/vestibular/ear_phenot1.00721654
77MP0003878_abnormal_ear_physiology1.00721654
78MP0001177_atelectasis1.00048027
79MP0000569_abnormal_digit_pigmentation0.99853912
80MP0002152_abnormal_brain_morphology0.99063486
81MP0000751_myopathy0.96008457
82MP0006276_abnormal_autonomic_nervous0.94499281
83MP0010352_gastrointestinal_tract_polyps0.93220466
84MP0002069_abnormal_eating/drinking_beha0.92995600
85MP0008874_decreased_physiological_sensi0.92432063
86MP0002234_abnormal_pharynx_morphology0.88517280
87MP0004742_abnormal_vestibular_system0.87776005
88MP0009931_abnormal_skin_appearance0.87437098
89MP0008872_abnormal_physiological_respon0.86683229
90MP0005409_darkened_coat_color0.86486695
91MP0005248_abnormal_Harderian_gland0.86086691
92MP0003123_paternal_imprinting0.85116738
93MP0004142_abnormal_muscle_tone0.84823265
94MP0005499_abnormal_olfactory_system0.84384057
95MP0005394_taste/olfaction_phenotype0.84384057
96MP0001905_abnormal_dopamine_level0.84002878
97MP0002089_abnormal_postnatal_growth/wei0.83548347
98MP0001849_ear_inflammation0.82552447
99MP0003866_abnormal_defecation0.81792965
100MP0002876_abnormal_thyroid_physiology0.81195246
101MP0005365_abnormal_bile_salt0.79235400
102MP0003638_abnormal_response/metabolism_0.78070385
103MP0010386_abnormal_urinary_bladder0.76818529
104MP0000462_abnormal_digestive_system0.76746911
105MP0000367_abnormal_coat/_hair0.76629719
106MP0010771_integument_phenotype0.74939344
107MP0000647_abnormal_sebaceous_gland0.74747127
108MP0004484_altered_response_of0.73544561
109MP0001963_abnormal_hearing_physiology0.72605979
110MP0010155_abnormal_intestine_physiology0.72558544
111MP0000627_abnormal_mammary_gland0.72429264
112MP0000681_abnormal_thyroid_gland0.71659314
113MP0004147_increased_porphyrin_level0.71619105
114MP0001664_abnormal_digestion0.71617575
115MP0010678_abnormal_skin_adnexa0.70413285
116MP0005275_abnormal_skin_tensile0.70359936
117MP0004510_myositis0.70013453
118MP0004085_abnormal_heartbeat0.68896377
119MP0004145_abnormal_muscle_electrophysio0.68295902
120MP0000477_abnormal_intestine_morphology0.67925918
121MP0003632_abnormal_nervous_system0.66848898
122MP0005501_abnormal_skin_physiology0.66303721
123MP0003283_abnormal_digestive_organ0.64034859
124MP0002229_neurodegeneration0.63908905
125MP0001346_abnormal_lacrimal_gland0.63684289
126MP0003122_maternal_imprinting0.62682770
127MP0005085_abnormal_gallbladder_physiolo0.61466574
128MP0009053_abnormal_anal_canal0.60352270
129MP0003566_abnormal_cell_adhesion0.60109331
130MP0000537_abnormal_urethra_morphology0.59921885
131MP0001529_abnormal_vocalization0.59642167
132MP0000631_abnormal_neuroendocrine_gland0.59263085
133MP0005551_abnormal_eye_electrophysiolog0.58141779
134MP0005535_abnormal_body_temperature0.57718211
135MP0000427_abnormal_hair_cycle0.57023631
136MP0002090_abnormal_vision0.56238285
137MP0005166_decreased_susceptibility_to0.56220123
138MP0005167_abnormal_blood-brain_barrier0.55161103
139MP0001485_abnormal_pinna_reflex0.54912076
140MP0000604_amyloidosis0.54615786
141MP0003690_abnormal_glial_cell0.54441930
142MP0002752_abnormal_somatic_nervous0.54343926
143MP0000467_abnormal_esophagus_morphology0.54165439
144MP0003634_abnormal_glial_cell0.53441725
145MP0004215_abnormal_myocardial_fiber0.52117007
146MP0002254_reproductive_system_inflammat0.51513477
147MP0010769_abnormal_survival0.51428987
148MP0000920_abnormal_myelination0.51182187
149MP0000013_abnormal_adipose_tissue0.50032773

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.22977550
2Myokymia (HP:0002411)7.39223744
3Abnormality of nail color (HP:0100643)5.99248574
4Focal seizures (HP:0007359)5.86560116
5Right ventricular cardiomyopathy (HP:0011663)5.25450727
6Visual hallucinations (HP:0002367)5.13512050
7Epileptic encephalopathy (HP:0200134)5.04616112
8Febrile seizures (HP:0002373)4.64333037
9Pili torti (HP:0003777)4.59515733
10Progressive cerebellar ataxia (HP:0002073)4.52042037
11Atonic seizures (HP:0010819)4.45205033
12Congenital ichthyosiform erythroderma (HP:0007431)4.01412528
13Absence seizures (HP:0002121)3.99181524
14Increased IgE level (HP:0003212)3.89966711
15Alopecia of scalp (HP:0002293)3.87335705
16Abnormality of the salivary glands (HP:0010286)3.85294801
17Hyperactive renin-angiotensin system (HP:0000841)3.81686785
18Generalized tonic-clonic seizures (HP:0002069)3.77786248
19Action tremor (HP:0002345)3.70923650
20Dialeptic seizures (HP:0011146)3.69749026
21Abnormal hair laboratory examination (HP:0003328)3.65567268
22Broad-based gait (HP:0002136)3.58072905
23Woolly hair (HP:0002224)3.49984768
24Impaired vibration sensation in the lower limbs (HP:0002166)3.48363171
25Lip pit (HP:0100267)3.37000551
26Gaze-evoked nystagmus (HP:0000640)3.34639590
27Ankle clonus (HP:0011448)3.33117566
28Poor eye contact (HP:0000817)3.13385465
29Supranuclear gaze palsy (HP:0000605)3.13359997
30Onycholysis (HP:0001806)3.13188020
31Ventricular fibrillation (HP:0001663)3.11854118
32Depression (HP:0000716)3.09812708
33Amblyopia (HP:0000646)3.07857681
34Dysmetria (HP:0001310)3.04776162
35Erythroderma (HP:0001019)3.04660603
36Hyperventilation (HP:0002883)3.04523911
37Genetic anticipation (HP:0003743)3.04379036
38Dysdiadochokinesis (HP:0002075)3.03010094
39Thick nail (HP:0001805)3.02899544
40Urinary bladder sphincter dysfunction (HP:0002839)2.98761454
41Flat acetabular roof (HP:0003180)2.98219764
42Abnormality of the lower motor neuron (HP:0002366)2.93408336
43Postural instability (HP:0002172)2.90754971
44Malnutrition (HP:0004395)2.89052982
45Mutism (HP:0002300)2.86875936
46Corneal erosion (HP:0200020)2.85875649
47Abnormal social behavior (HP:0012433)2.84309527
48Impaired social interactions (HP:0000735)2.84309527
49Papilledema (HP:0001085)2.78834971
50Obstructive sleep apnea (HP:0002870)2.76334475
51Abnormal eating behavior (HP:0100738)2.76286007
52Bronchomalacia (HP:0002780)2.73304969
53Erythema (HP:0010783)2.73091267
54Decreased circulating renin level (HP:0003351)2.71224739
55Impaired smooth pursuit (HP:0007772)2.66861581
56Akinesia (HP:0002304)2.66263849
57Stereotypic behavior (HP:0000733)2.65709744
58Abnormality of secondary sexual hair (HP:0009888)2.65206490
59Abnormality of the axillary hair (HP:0100134)2.65206490
60Torticollis (HP:0000473)2.65139437
61Abnormal blistering of the skin (HP:0008066)2.64894458
62Truncal ataxia (HP:0002078)2.63835396
63Anxiety (HP:0000739)2.62532313
64Megalencephaly (HP:0001355)2.60461508
65Abnormality of renin-angiotensin system (HP:0000847)2.59672718
66Intention tremor (HP:0002080)2.57287669
67Focal dystonia (HP:0004373)2.53792766
68Excessive salivation (HP:0003781)2.49829725
69Drooling (HP:0002307)2.49829725
70Impaired vibratory sensation (HP:0002495)2.39464318
71Nail dystrophy (HP:0008404)2.38745473
72Fetal akinesia sequence (HP:0001989)2.38344305
73Hyperparathyroidism (HP:0000843)2.38183146
74Dysmetric saccades (HP:0000641)2.36952285
75Urinary urgency (HP:0000012)2.36731816
76Annular pancreas (HP:0001734)2.33898821
77Neonatal short-limb short stature (HP:0008921)2.32399696
78Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.31845860
79Abnormality of the dental root (HP:0006486)2.31552183
80Taurodontia (HP:0000679)2.31552183
81Abnormality of permanent molar morphology (HP:0011071)2.31552183
82Ankyloglossia (HP:0010296)2.28187387
83Hemiplegia (HP:0002301)2.27136197
84Diplopia (HP:0000651)2.26966584
85Abnormality of binocular vision (HP:0011514)2.26966584
86Bundle branch block (HP:0011710)2.26882378
87Abnormality of ocular smooth pursuit (HP:0000617)2.26498224
88Abnormality of glutamine family amino acid metabolism (HP:0010902)2.21407760
89Metabolic alkalosis (HP:0200114)2.20237463
90Hemiparesis (HP:0001269)2.16679017
91Absent speech (HP:0001344)2.16237915
92Palmoplantar keratoderma (HP:0000982)2.15812414
93Aplasia involving bones of the extremities (HP:0009825)2.14557685
94Aplasia involving bones of the upper limbs (HP:0009823)2.14557685
95Aplasia of the phalanges of the hand (HP:0009802)2.14557685
96Bradykinesia (HP:0002067)2.13736309
97Epileptiform EEG discharges (HP:0011182)2.12802227
98Hyperaldosteronism (HP:0000859)2.12386329
99Scanning speech (HP:0002168)2.12055365
100Pointed chin (HP:0000307)2.11757874
101Hypoplasia of dental enamel (HP:0006297)2.11747643
102Abnormality of molar (HP:0011077)2.07703574
103Abnormality of molar morphology (HP:0011070)2.07703574
104Spastic gait (HP:0002064)2.06792388
105Partial duplication of thumb phalanx (HP:0009944)2.05994456
106Craniofacial dystonia (HP:0012179)2.04893268
107Split foot (HP:0001839)2.03413694
108Hypohidrosis (HP:0000966)2.02889988
109Abnormality of chloride homeostasis (HP:0011422)2.02336281
110Progressive inability to walk (HP:0002505)2.01996082
111Neuronal loss in central nervous system (HP:0002529)2.01823705
112Lower limb amyotrophy (HP:0007210)2.00973265
113Abnormality of the dental pulp (HP:0006479)2.00273085
114Plantar hyperkeratosis (HP:0007556)1.99836032
115Hyperkalemia (HP:0002153)1.99203259
116Neonatal death (HP:0003811)1.99178451
117Generalized myoclonic seizures (HP:0002123)1.98681253
118Status epilepticus (HP:0002133)1.96133895
119EEG with generalized epileptiform discharges (HP:0011198)1.95041729
120Cerebral inclusion bodies (HP:0100314)1.94129012
121Acanthosis nigricans (HP:0000956)1.93374166
122Incomplete penetrance (HP:0003829)1.92492061
123Dehydration (HP:0001944)1.91370527
124Neurofibrillary tangles (HP:0002185)1.90674514
125Germ cell neoplasia (HP:0100728)1.90407042
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90225682
127Sparse eyelashes (HP:0000653)1.88764825
128Hypotrichosis (HP:0001006)1.87426908
129Palmoplantar hyperkeratosis (HP:0000972)1.87198355
130Curly hair (HP:0002212)1.85784425
131Abnormality of hair growth rate (HP:0011363)1.85468799
132Slow-growing hair (HP:0002217)1.85468799
133Lower limb muscle weakness (HP:0007340)1.85176649
134Hypsarrhythmia (HP:0002521)1.84190125
135Milia (HP:0001056)1.84090417
136Parakeratosis (HP:0001036)1.84023243
137Abnormality of the distal phalanx of the thumb (HP:0009617)1.82582477
138Sleep apnea (HP:0010535)1.82578558
139Spinal cord compression (HP:0002176)1.81709171
140Inability to walk (HP:0002540)1.80418946
141Gait ataxia (HP:0002066)1.79927086
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78782167
143Ridged nail (HP:0001807)1.78326288
144Absent eyelashes (HP:0000561)1.78227742
145Abnormal EKG (HP:0003115)1.77731401
146Abnormality of salivation (HP:0100755)1.77511158
147Advanced eruption of teeth (HP:0006288)1.77273570
148Fragile nails (HP:0001808)1.77082934
149Distal upper limb amyotrophy (HP:0007149)1.76252410
150Upper limb amyotrophy (HP:0009129)1.76252410
151Conjunctival hamartoma (HP:0100780)1.74725715
152Amelogenesis imperfecta (HP:0000705)1.74486577
153Abnormality of sodium homeostasis (HP:0010931)1.74260070
154Insomnia (HP:0100785)1.73443935
155Abnormality of saccadic eye movements (HP:0000570)1.72017256
156Visceral angiomatosis (HP:0100761)1.71630076
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.71450028
158Polyphagia (HP:0002591)1.71051951
159Syncope (HP:0001279)1.69568594
160Inappropriate behavior (HP:0000719)1.69320244
161Intellectual disability, profound (HP:0002187)1.69153595
162Palmar hyperkeratosis (HP:0010765)1.69099916
163Axonal loss (HP:0003447)1.68637616
164Thickened helices (HP:0000391)1.67989638
165Thin bony cortex (HP:0002753)1.66757834
166Termporal pattern (HP:0011008)1.66629607
167Insidious onset (HP:0003587)1.66629607
168Lower limb asymmetry (HP:0100559)1.66392021
169Rapidly progressive (HP:0003678)1.66079174

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.82218672
2NTRK34.70560898
3MAP3K93.90151662
4CDK123.72418966
5MST1R3.22892182
6EPHA23.10140645
7DAPK22.84861534
8MAP3K42.68101448
9MARK12.55519535
10MINK12.53122304
11PRKD32.50244444
12PAK62.32541021
13TRIB32.27458115
14KSR22.25177371
15MAP2K72.23425147
16NTRK21.98713157
17MAP3K121.95808264
18MATK1.93210769
19CAMKK11.91244206
20RIPK41.89340748
21MAP2K41.85553567
22PRPF4B1.84584010
23CASK1.78943249
24DAPK11.78935549
25PIK3CA1.75076751
26KSR11.71274804
27SIK11.58950157
28MAPKAPK31.54808081
29CDK51.54723460
30MET1.53596691
31STK381.52246982
32CDK191.51674562
33MAP3K21.50827503
34SIK21.48445669
35TAOK11.48261980
36ERBB21.47309925
37ERN11.47285974
38NTRK11.43491295
39PLK21.41174246
40TNIK1.40701922
41EEF2K1.32579398
42MAP3K131.31342980
43PRKG21.30998893
44MAPK131.29257150
45SMG11.24760873
46PRKCG1.21784386
47CAMK11.21235001
48GRK51.19055550
49TYRO31.18501807
50ICK1.17898625
51FES1.10274479
52LATS21.10174330
53PTK21.02129895
54STK110.99483626
55ARAF0.96391593
56CAMK2A0.92525227
57SGK20.92045537
58SGK2230.91547504
59SGK4940.91547504
60FER0.90334756
61RAF10.87366812
62PRKCH0.84620040
63TESK10.84470868
64MAP3K70.84372248
65SGK30.83774562
66CDK180.83525800
67PTK2B0.82444335
68NME10.81701897
69CDK150.81688711
70MARK20.81032826
71MUSK0.78952553
72UHMK10.78555653
73ALK0.77556785
74FGFR40.76612758
75PDK10.75483443
76FGFR30.75450220
77SGK10.74701788
78CDK140.73895279
79PTK60.73609136
80CAMK2B0.73500946
81DMPK0.73344270
82BMPR20.71741126
83SIK30.71715506
84CDK11A0.71092736
85PHKG10.71014707
86PHKG20.71014707
87MAP3K10.70754979
88RET0.70437167
89DYRK1A0.69435960
90PAK30.68728387
91CAMKK20.68579535
92PINK10.68353802
93PDPK10.64567590
94STK240.63493364
95CAMK1D0.62574505
96CAMK40.61636864
97PNCK0.60373520
98GRK60.59375413
99LMTK20.59254926
100OXSR10.57576673
101EPHB20.57478161
102TNK20.56951375
103FGFR10.54976197
104MAP2K10.54023914
105MAP3K60.52421980
106MAP2K20.50807853
107RPS6KB20.50742418
108CCNB10.49150789
109NEK60.48453836
110PDGFRA0.48445333
111WNK10.47515018
112RPS6KA30.47155355
113MAPK150.47011999
114CDC42BPA0.46957480
115RIPK10.46828024
116CDK70.45983191
117RPS6KA20.45895842
118ACVR1B0.44556577
119PRKCZ0.43589461
120BMX0.43526188
121FYN0.42851403
122BRSK10.42187604
123PKN20.42172896
124DAPK30.42108845
125RPS6KB10.41244727
126MAP3K110.40954178
127CSNK1G20.40026779
128PRKCE0.39871285
129MAPK120.39185523
130DDR20.39154495
131AKT30.38550083
132MAPK100.38338418
133FGR0.37998917
134CAMK1G0.33965947
135CAMK2G0.32302096
136MAP2K60.30526386
137FGFR20.28397543
138PRKD20.28184843

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.41216811
2Synaptic vesicle cycle_Homo sapiens_hsa047213.06329493
3Long-term potentiation_Homo sapiens_hsa047202.79535352
4Olfactory transduction_Homo sapiens_hsa047402.76510946
5Circadian entrainment_Homo sapiens_hsa047132.73592698
6Cyanoamino acid metabolism_Homo sapiens_hsa004602.72076915
7Glutamatergic synapse_Homo sapiens_hsa047242.57736276
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52884102
9Amphetamine addiction_Homo sapiens_hsa050312.44113638
10GABAergic synapse_Homo sapiens_hsa047272.37090256
11Morphine addiction_Homo sapiens_hsa050322.28335292
12Salivary secretion_Homo sapiens_hsa049702.27568433
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.08023124
14Gastric acid secretion_Homo sapiens_hsa049712.05795659
15Insulin secretion_Homo sapiens_hsa049112.01071464
16Dopaminergic synapse_Homo sapiens_hsa047282.00845960
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97309626
18Cholinergic synapse_Homo sapiens_hsa047251.88960567
19Oxytocin signaling pathway_Homo sapiens_hsa049211.73963587
20Long-term depression_Homo sapiens_hsa047301.70336219
21Histidine metabolism_Homo sapiens_hsa003401.68602701
22Calcium signaling pathway_Homo sapiens_hsa040201.67755125
23GnRH signaling pathway_Homo sapiens_hsa049121.65164371
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64241821
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62710870
26Renin secretion_Homo sapiens_hsa049241.61511873
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.54586598
28Taste transduction_Homo sapiens_hsa047421.53942797
29Serotonergic synapse_Homo sapiens_hsa047261.50351694
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.47865362
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.41290223
32Arginine biosynthesis_Homo sapiens_hsa002201.41226167
33Glioma_Homo sapiens_hsa052141.37651190
34Cocaine addiction_Homo sapiens_hsa050301.36605580
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.30269284
36cAMP signaling pathway_Homo sapiens_hsa040241.30121917
37Fat digestion and absorption_Homo sapiens_hsa049751.24073741
38Type II diabetes mellitus_Homo sapiens_hsa049301.24056588
39Gap junction_Homo sapiens_hsa045401.23720737
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.21614722
41Melanogenesis_Homo sapiens_hsa049161.21107836
42ErbB signaling pathway_Homo sapiens_hsa040121.21064367
43Axon guidance_Homo sapiens_hsa043601.20133169
44Estrogen signaling pathway_Homo sapiens_hsa049151.19359998
45Collecting duct acid secretion_Homo sapiens_hsa049661.16119899
46Linoleic acid metabolism_Homo sapiens_hsa005911.11055257
47Vitamin digestion and absorption_Homo sapiens_hsa049771.08237283
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07453112
49Nitrogen metabolism_Homo sapiens_hsa009101.05458599
50Fructose and mannose metabolism_Homo sapiens_hsa000511.02007164
51Pancreatic secretion_Homo sapiens_hsa049721.01918311
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.00356587
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97538476
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96272389
55Dorso-ventral axis formation_Homo sapiens_hsa043200.92221922
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.90793152
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88320665
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88058108
59VEGF signaling pathway_Homo sapiens_hsa043700.87625468
60Choline metabolism in cancer_Homo sapiens_hsa052310.85687056
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85458807
62Notch signaling pathway_Homo sapiens_hsa043300.83718501
63Oocyte meiosis_Homo sapiens_hsa041140.83487055
64Protein digestion and absorption_Homo sapiens_hsa049740.82466448
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81613078
66Glycerophospholipid metabolism_Homo sapiens_hsa005640.81038763
67Ether lipid metabolism_Homo sapiens_hsa005650.78743420
68Sphingolipid metabolism_Homo sapiens_hsa006000.77669551
69Phenylalanine metabolism_Homo sapiens_hsa003600.75450192
70MAPK signaling pathway_Homo sapiens_hsa040100.75439822
71Arginine and proline metabolism_Homo sapiens_hsa003300.74906117
72Thyroid hormone synthesis_Homo sapiens_hsa049180.74828517
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74744084
74PPAR signaling pathway_Homo sapiens_hsa033200.72435813
75Arachidonic acid metabolism_Homo sapiens_hsa005900.71544929
76Dilated cardiomyopathy_Homo sapiens_hsa054140.70990433
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.70961444
78Ras signaling pathway_Homo sapiens_hsa040140.70317551
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69975681
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68336938
81Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67208291
82Vibrio cholerae infection_Homo sapiens_hsa051100.66544639
83Rap1 signaling pathway_Homo sapiens_hsa040150.66063855
84Phototransduction_Homo sapiens_hsa047440.65879892
85Renin-angiotensin system_Homo sapiens_hsa046140.65863472
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.64960002
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62516124
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.60724432
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59791588
90Circadian rhythm_Homo sapiens_hsa047100.59442896
91mTOR signaling pathway_Homo sapiens_hsa041500.59330654
92Inositol phosphate metabolism_Homo sapiens_hsa005620.58721051
93Non-small cell lung cancer_Homo sapiens_hsa052230.58571694
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.58498209
95Cardiac muscle contraction_Homo sapiens_hsa042600.57525603
96Endometrial cancer_Homo sapiens_hsa052130.57386951
97Glucagon signaling pathway_Homo sapiens_hsa049220.57173553
98Wnt signaling pathway_Homo sapiens_hsa043100.57146420
99Glycerolipid metabolism_Homo sapiens_hsa005610.57094562
100Endocytosis_Homo sapiens_hsa041440.55214654
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55144470
102Vitamin B6 metabolism_Homo sapiens_hsa007500.53863744
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50842589
104Adherens junction_Homo sapiens_hsa045200.50536553
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47252476
106Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47194283
107Fatty acid biosynthesis_Homo sapiens_hsa000610.47192460
108ABC transporters_Homo sapiens_hsa020100.46047347
109Thyroid cancer_Homo sapiens_hsa052160.45688325
110Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45639543
111AMPK signaling pathway_Homo sapiens_hsa041520.45075327
112African trypanosomiasis_Homo sapiens_hsa051430.43903367
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43870241
114Renal cell carcinoma_Homo sapiens_hsa052110.43599249
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43514488
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.42321458
117Ovarian steroidogenesis_Homo sapiens_hsa049130.42159074
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42146645
119Bile secretion_Homo sapiens_hsa049760.40795795
120Chemokine signaling pathway_Homo sapiens_hsa040620.39734760
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39476622
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39416457
123Insulin signaling pathway_Homo sapiens_hsa049100.38100906
124Alcoholism_Homo sapiens_hsa050340.36404731
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35853040
126Type I diabetes mellitus_Homo sapiens_hsa049400.32098449
127Tight junction_Homo sapiens_hsa045300.32096900
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31917651
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31644050
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30791503
131Mineral absorption_Homo sapiens_hsa049780.30631098
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30524018

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