RAPGEF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.94004134
2negative T cell selection (GO:0043383)6.78739505
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.64785089
4negative regulation of cell killing (GO:0031342)6.64785089
5negative thymic T cell selection (GO:0045060)6.55319626
6positive thymic T cell selection (GO:0045059)5.88096744
7positive T cell selection (GO:0043368)5.58281142
8regulation of gamma-delta T cell differentiation (GO:0045586)5.45044230
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.39242777
10thymic T cell selection (GO:0045061)5.36441879
11regulation of isotype switching to IgG isotypes (GO:0048302)5.25711391
12T cell selection (GO:0045058)5.17455517
13regulation of gamma-delta T cell activation (GO:0046643)5.12190737
14antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.04543537
15antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.04543537
16leukocyte aggregation (GO:0070486)5.01388013
17response to interleukin-15 (GO:0070672)4.95626364
18interferon-gamma production (GO:0032609)4.91886726
19cellular response to interleukin-15 (GO:0071350)4.90891097
20antigen processing and presentation of endogenous antigen (GO:0019883)4.63922730
21positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.63140373
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.60948974
23regulation of B cell receptor signaling pathway (GO:0050855)4.56243214
24positive regulation of granulocyte differentiation (GO:0030854)4.50895704
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.50287061
26T cell migration (GO:0072678)4.32086766
27establishment of protein localization to Golgi (GO:0072600)4.26720777
28regulation of interleukin-12 biosynthetic process (GO:0045075)4.18681613
29regulation of T cell tolerance induction (GO:0002664)4.11473025
30regulation of alpha-beta T cell proliferation (GO:0046640)4.10787348
31protein targeting to Golgi (GO:0000042)4.09068962
32positive regulation of isotype switching (GO:0045830)4.02710744
33regulation of regulatory T cell differentiation (GO:0045589)3.99780908
34T cell receptor signaling pathway (GO:0050852)3.98523102
35tolerance induction (GO:0002507)3.97780967
36lymphocyte costimulation (GO:0031294)3.90888492
37T cell costimulation (GO:0031295)3.88739839
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.87270882
39histone H3-K36 demethylation (GO:0070544)3.80007448
40retrograde transport, vesicle recycling within Golgi (GO:0000301)3.78379588
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.77571654
42negative regulation of T cell mediated immunity (GO:0002710)3.70965422
43antigen receptor-mediated signaling pathway (GO:0050851)3.70348931
44positive regulation of alpha-beta T cell proliferation (GO:0046641)3.65840911
45positive regulation of interleukin-2 production (GO:0032743)3.60630586
46monoubiquitinated protein deubiquitination (GO:0035520)3.59999577
47regulation of isotype switching (GO:0045191)3.58793459
48positive regulation of DNA recombination (GO:0045911)3.58659740
49regulation of T cell receptor signaling pathway (GO:0050856)3.58642672
50regulation of interleukin-2 biosynthetic process (GO:0045076)3.55027841
51positive regulation of humoral immune response (GO:0002922)3.48118782
52regulation of B cell differentiation (GO:0045577)3.47366099
53protein K11-linked deubiquitination (GO:0035871)3.47335900
54B cell receptor signaling pathway (GO:0050853)3.46767942
55histone mRNA catabolic process (GO:0071044)3.41867770
56peptidyl-lysine trimethylation (GO:0018023)3.33117792
57alpha-beta T cell activation (GO:0046631)3.28985396
58protein K48-linked deubiquitination (GO:0071108)3.28585299
59interkinetic nuclear migration (GO:0022027)3.27547568
60NIK/NF-kappaB signaling (GO:0038061)3.26933013
61CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.25205749
62T-helper cell differentiation (GO:0042093)3.25205749
63positive regulation of B cell mediated immunity (GO:0002714)3.23161495
64positive regulation of immunoglobulin mediated immune response (GO:0002891)3.23161495
65histone H3-K4 trimethylation (GO:0080182)3.19844089
66alpha-beta T cell differentiation (GO:0046632)3.18242700
67positive regulation of tolerance induction (GO:0002645)3.14537309
68T cell differentiation (GO:0030217)3.10652857
69leukocyte cell-cell adhesion (GO:0007159)3.09295464
70neural tube formation (GO:0001841)3.08622892
71nuclear pore complex assembly (GO:0051292)3.07730192
72CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.04315387
73regulation of immunoglobulin mediated immune response (GO:0002889)3.04287549
74natural killer cell activation (GO:0030101)3.03823731
75regulation of B cell mediated immunity (GO:0002712)3.03533033
76negative regulation of lymphocyte mediated immunity (GO:0002707)3.02815740
77T cell homeostasis (GO:0043029)3.01932652
78myeloid dendritic cell activation (GO:0001773)3.01776789
79histone H3-K9 modification (GO:0061647)3.01286459
80regulation of tolerance induction (GO:0002643)3.00030188
81positive regulation of immunoglobulin production (GO:0002639)2.99278212
82CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98786029
83positive regulation of B cell differentiation (GO:0045579)2.95213609
84mast cell degranulation (GO:0043303)2.94643613
85mast cell activation involved in immune response (GO:0002279)2.94643613
86regulation of immunoglobulin production (GO:0002637)2.93493652
87activated T cell proliferation (GO:0050798)2.93136623
88T cell differentiation involved in immune response (GO:0002292)2.92574009
89alpha-beta T cell differentiation involved in immune response (GO:0002293)2.92574009
90alpha-beta T cell activation involved in immune response (GO:0002287)2.92574009
91regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.92324580
92regulation of granulocyte differentiation (GO:0030852)2.90523394
93mast cell activation (GO:0045576)2.89365020
94negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87681074
95pore complex assembly (GO:0046931)2.87608999
96histone H3-K9 methylation (GO:0051567)2.87167165
97angiogenesis involved in wound healing (GO:0060055)2.85441546
98positive regulation of B cell proliferation (GO:0030890)2.85368772
99regulation of B cell proliferation (GO:0030888)2.84658507
100B cell proliferation (GO:0042100)2.83128837
101lymphocyte homeostasis (GO:0002260)2.82918133
102regulation of T cell mediated cytotoxicity (GO:0001914)2.82346505
103T cell proliferation (GO:0042098)2.81713611
104negative regulation of phagocytosis (GO:0050765)2.81305497
105T cell activation (GO:0042110)2.80543338
106negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.79014233
107regulation of response to interferon-gamma (GO:0060330)2.78078203
108B cell homeostasis (GO:0001782)2.78035701
109regulation of natural killer cell mediated immunity (GO:0002715)2.77047008
110regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77047008
111positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76774150
112cellular response to ethanol (GO:0071361)2.75938916
113protein K63-linked deubiquitination (GO:0070536)2.75287129
114dosage compensation (GO:0007549)2.75032840
115regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.75016554
116negative regulation of adaptive immune response (GO:0002820)2.74388739
117regulation of interleukin-2 production (GO:0032663)2.73190477
118regulation of alpha-beta T cell activation (GO:0046634)2.72918044
119positive regulation of B cell activation (GO:0050871)2.72426851
120hepatocyte apoptotic process (GO:0097284)2.72271139
121immune response-activating cell surface receptor signaling pathway (GO:0002429)2.72079108
122protein localization to Golgi apparatus (GO:0034067)2.71367770
123T cell lineage commitment (GO:0002360)2.71232128
124regulation of chronic inflammatory response (GO:0002676)2.70695429
125negative regulation of leukocyte mediated immunity (GO:0002704)2.70541048
126mucosal-associated lymphoid tissue development (GO:0048537)2.70315285
127Peyers patch development (GO:0048541)2.70315285
128negative regulation of B cell proliferation (GO:0030889)2.70169306
129cellular extravasation (GO:0045123)2.68947366
130rRNA catabolic process (GO:0016075)2.68847546
131T cell activation involved in immune response (GO:0002286)2.68152734
132positive regulation of natural killer cell mediated immunity (GO:0002717)2.68039951
133regulation of cell killing (GO:0031341)2.67050715
134histone H3-K4 methylation (GO:0051568)2.65248481
135regulation of fibroblast apoptotic process (GO:2000269)2.64909044
136histone lysine demethylation (GO:0070076)2.64673168
137CD4-positive, alpha-beta T cell activation (GO:0035710)2.63291486
138positive regulation of mRNA catabolic process (GO:0061014)2.61740341
139regulation of leukocyte mediated cytotoxicity (GO:0001910)2.61362518
140microtubule nucleation (GO:0007020)2.61357167
141regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.60741754
142positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.60741754
143nuclear pore organization (GO:0006999)2.60682176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.23718342
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.26696439
3E2F7_22180533_ChIP-Seq_HELA_Human5.14228047
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.44970851
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.95537799
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.73135055
7FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.54520916
8RUNX_20019798_ChIP-Seq_JUKART_Human3.54125199
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45988991
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.18548808
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.16815548
12* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.07783192
13MYB_26560356_Chip-Seq_TH2_Human3.06507761
14MYC_22102868_ChIP-Seq_BL_Human2.77692560
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.73517459
16* MYB_26560356_Chip-Seq_TH1_Human2.68069293
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63706871
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51601629
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.47402900
20MAF_26560356_Chip-Seq_TH1_Human2.46822401
21SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34678747
22IRF8_27001747_Chip-Seq_BMDM_Mouse2.34124415
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.30395808
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.27703414
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27101087
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.22339378
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.21254951
28* UTX_26944678_Chip-Seq_JUKART_Human2.16716850
29TAF15_26573619_Chip-Seq_HEK293_Human2.10085183
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08821064
31IGF1R_20145208_ChIP-Seq_DFB_Human2.08182726
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.99719954
33SCL_19346495_ChIP-Seq_HPC-7_Human1.96464045
34VDR_21846776_ChIP-Seq_THP-1_Human1.93514756
35GBX2_23144817_ChIP-Seq_PC3_Human1.91967383
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.91680024
37GATA3_27048872_Chip-Seq_THYMUS_Human1.89588643
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86346738
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85650135
40FOXM1_23109430_ChIP-Seq_U2OS_Human1.83483428
41* SPI1_23547873_ChIP-Seq_NB4_Human1.81220706
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.79257957
43TCF7_22412390_ChIP-Seq_EML_Mouse1.75843971
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73027316
45* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.72865290
46E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72385009
47ER_23166858_ChIP-Seq_MCF-7_Human1.67668356
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66968049
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66875025
50BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63100298
51MAF_26560356_Chip-Seq_TH2_Human1.60666893
52VDR_24763502_ChIP-Seq_THP-1_Human1.58203127
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56488795
54* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54763768
55STAT3_23295773_ChIP-Seq_U87_Human1.53040140
56GATA1_22025678_ChIP-Seq_K562_Human1.49734021
57PU_27001747_Chip-Seq_BMDM_Mouse1.49020101
58SPI1_23127762_ChIP-Seq_K562_Human1.48866086
59PRDM14_20953172_ChIP-Seq_ESCs_Human1.46063685
60FUS_26573619_Chip-Seq_HEK293_Human1.44481507
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40346960
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40299214
63ZNF274_21170338_ChIP-Seq_K562_Hela1.33567691
64VDR_22108803_ChIP-Seq_LS180_Human1.33313179
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.33215838
66GATA3_26560356_Chip-Seq_TH2_Human1.28103851
67TP53_16413492_ChIP-PET_HCT116_Human1.27526980
68EWS_26573619_Chip-Seq_HEK293_Human1.27107408
69TCF4_23295773_ChIP-Seq_U87_Human1.25852294
70RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25815954
71MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25266511
72CBP_20019798_ChIP-Seq_JUKART_Human1.24998168
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24998168
74* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24305378
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23867199
76SMAD4_21799915_ChIP-Seq_A2780_Human1.23502015
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22377293
78* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19505485
79P300_19829295_ChIP-Seq_ESCs_Human1.19349458
80* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18954301
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18545685
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.18090150
83SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17975338
84SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17463851
85* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15834462
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15249485
87* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15164249
88* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13536005
89CIITA_25753668_ChIP-Seq_RAJI_Human1.13482255
90KDM2B_26808549_Chip-Seq_DND41_Human1.12766089
91* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11994258
92* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11994258
93IRF1_19129219_ChIP-ChIP_H3396_Human1.11664466
94* AR_21572438_ChIP-Seq_LNCaP_Human1.08342901
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.07912021
96CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07864965
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05667105
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05574837
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05393177
100TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02984633
101NANOG_18555785_Chip-Seq_ESCs_Mouse1.01867539
102* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01318151
103OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00611723
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00507680
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00102273
106HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99970052
107NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98426629
108GATA3_26560356_Chip-Seq_TH1_Human0.98421888
109* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98200458
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97689170
111ARNT_22903824_ChIP-Seq_MCF-7_Human0.96311520
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.95645228
113KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95070256
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94934181
115* ELK1_19687146_ChIP-ChIP_HELA_Human0.93274046
116PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93157634
117VDR_24787735_ChIP-Seq_THP-1_Human0.92576759
118ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90806822
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90469300
120SALL1_21062744_ChIP-ChIP_HESCs_Human0.90030171
121TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.90017741
122FLI1_27457419_Chip-Seq_LIVER_Mouse0.89061442
123* KDM2B_26808549_Chip-Seq_JURKAT_Human0.88688724
124E2F1_21310950_ChIP-Seq_MCF-7_Human0.88455388
125KDM2B_26808549_Chip-Seq_REH_Human0.87986571
126* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.87394167
127P53_22387025_ChIP-Seq_ESCs_Mouse0.87264256
128* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86788106
129* CRX_20693478_ChIP-Seq_RETINA_Mouse0.86621111
130SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85660243
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85353304
132BCAT_22108803_ChIP-Seq_LS180_Human0.85346238
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79700620
134* VDR_23849224_ChIP-Seq_CD4+_Human0.75394947
135* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73555056
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.73421554
137GATA1_19941827_ChIP-Seq_MEL_Mouse0.73074899
138* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72555073
139* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.72327985
140NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70013015
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.68853347
142TP63_19390658_ChIP-ChIP_HaCaT_Human0.68220997
143PKCTHETA_26484144_Chip-Seq_BREAST_Human0.67738995
144NCOR1_26117541_ChIP-Seq_K562_Human0.66337272
145FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.65896476
146ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65640962
147* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.64945246
148FOXP3_21729870_ChIP-Seq_TREG_Human0.64480709
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.63349440
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.63216002
151* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63098317
152* ELF1_17652178_ChIP-ChIP_JURKAT_Human0.62839425
153PCGF2_27294783_Chip-Seq_ESCs_Mouse0.62011373
154STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.61900763
155* SMRT_27268052_Chip-Seq_Bcells_Human0.60925690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.65909703
2MP0005671_abnormal_response_to3.89047073
3MP0001835_abnormal_antigen_presentation3.58517623
4MP0002166_altered_tumor_susceptibility3.36889360
5MP0000685_abnormal_immune_system3.21136420
6MP0001800_abnormal_humoral_immune3.10089030
7MP0005387_immune_system_phenotype3.00540139
8MP0001790_abnormal_immune_system3.00540139
9MP0002396_abnormal_hematopoietic_system2.85087900
10MP0002006_tumorigenesis2.81425393
11MP0005000_abnormal_immune_tolerance2.69366103
12MP0002420_abnormal_adaptive_immunity2.67566313
13MP0002398_abnormal_bone_marrow2.64567390
14MP0001819_abnormal_immune_cell2.63456310
15MP0002723_abnormal_immune_serum2.61292232
16MP0001873_stomach_inflammation2.58462028
17MP0002452_abnormal_antigen_presenting2.58179938
18MP0002009_preneoplasia2.57767528
19MP0003300_gastrointestinal_ulcer2.43662321
20MP0009785_altered_susceptibility_to2.38898705
21MP0003436_decreased_susceptibility_to2.35946125
22MP0000703_abnormal_thymus_morphology2.32361281
23MP0003303_peritoneal_inflammation2.29953512
24MP0002405_respiratory_system_inflammati2.27994738
25MP0000716_abnormal_immune_system2.26771407
26MP0005025_abnormal_response_to2.14136656
27MP0002148_abnormal_hypersensitivity_rea2.09276376
28MP0004808_abnormal_hematopoietic_stem2.06001454
29* MP0002722_abnormal_immune_system2.04181158
30* MP0000689_abnormal_spleen_morphology2.02352491
31MP0009333_abnormal_splenocyte_physiolog1.98655685
32MP0010155_abnormal_intestine_physiology1.96331019
33MP0008057_abnormal_DNA_replication1.92965497
34MP0002419_abnormal_innate_immunity1.92138829
35MP0003866_abnormal_defecation1.86827752
36MP0002429_abnormal_blood_cell1.84131838
37MP0001853_heart_inflammation1.82758108
38MP0005310_abnormal_salivary_gland1.82213910
39MP0006082_CNS_inflammation1.81626211
40MP0000569_abnormal_digit_pigmentation1.78335102
41MP0004510_myositis1.71972689
42MP0003724_increased_susceptibility_to1.69376950
43MP0005464_abnormal_platelet_physiology1.62349377
44MP0004947_skin_inflammation1.58853866
45MP0001845_abnormal_inflammatory_respons1.51246060
46MP0005397_hematopoietic_system_phenotyp1.50000715
47MP0001545_abnormal_hematopoietic_system1.50000715
48MP0008961_abnormal_basal_metabolism1.46972614
49MP0002933_joint_inflammation1.46151646
50MP0000465_gastrointestinal_hemorrhage1.42327455
51MP0003656_abnormal_erythrocyte_physiolo1.32910784
52MP0010352_gastrointestinal_tract_polyps1.32778371
53MP0000490_abnormal_crypts_of1.29102154
54MP0010094_abnormal_chromosome_stability1.27598424
55MP0001851_eye_inflammation1.27254575
56MP0003221_abnormal_cardiomyocyte_apopto1.20974068
57MP0001348_abnormal_lacrimal_gland1.20770458
58MP0000427_abnormal_hair_cycle1.17118037
59MP0003077_abnormal_cell_cycle1.16242042
60MP0003787_abnormal_imprinting1.13803392
61MP0001986_abnormal_taste_sensitivity1.13354321
62MP0005174_abnormal_tail_pigmentation1.10513715
63MP0000858_altered_metastatic_potential1.07577959
64MP0008995_early_reproductive_senescence1.06210319
65MP0002102_abnormal_ear_morphology1.06028835
66MP0004130_abnormal_muscle_cell1.04508828
67MP0005083_abnormal_biliary_tract1.04309764
68MP0003045_fibrosis1.04262274
69MP0000015_abnormal_ear_pigmentation1.03516195
70MP0003448_altered_tumor_morphology1.01438895
71MP0002019_abnormal_tumor_incidence1.01255270
72MP0009278_abnormal_bone_marrow0.98491379
73MP0001533_abnormal_skeleton_physiology0.97905389
74MP0008877_abnormal_DNA_methylation0.95247354
75MP0005075_abnormal_melanosome_morpholog0.90818682
76MP0008058_abnormal_DNA_repair0.90179199
77MP0010307_abnormal_tumor_latency0.89633838
78MP0008007_abnormal_cellular_replicative0.88086730
79MP0002095_abnormal_skin_pigmentation0.88038855
80MP0001919_abnormal_reproductive_system0.87523195
81MP0005076_abnormal_cell_differentiation0.85384866
82MP0003111_abnormal_nucleus_morphology0.85351590
83MP0005023_abnormal_wound_healing0.84854654
84MP0003693_abnormal_embryo_hatching0.82143811
85MP0003121_genomic_imprinting0.81550140
86MP0003890_abnormal_embryonic-extraembry0.81185426
87MP0008469_abnormal_protein_level0.80096187
88MP0005423_abnormal_somatic_nervous0.79952344
89MP0004142_abnormal_muscle_tone0.78742486
90MP0002928_abnormal_bile_duct0.77344278
91MP0003183_abnormal_peptide_metabolism0.75742202
92MP0002138_abnormal_hepatobiliary_system0.75071976
93MP0004381_abnormal_hair_follicle0.74741902
94MP0003880_abnormal_central_pattern0.74482171
95MP0003828_pulmonary_edema0.74127742
96MP0004883_abnormal_blood_vessel0.72866879
97MP0005410_abnormal_fertilization0.72748948
98MP0002998_abnormal_bone_remodeling0.71812686
99MP0005551_abnormal_eye_electrophysiolog0.71171551
100MP0001929_abnormal_gametogenesis0.71027450
101MP0005084_abnormal_gallbladder_morpholo0.70925231
102MP0003091_abnormal_cell_migration0.70126117
103MP0005253_abnormal_eye_physiology0.69857526
104MP0005645_abnormal_hypothalamus_physiol0.67672648
105MP0009115_abnormal_fat_cell0.67557589
106MP0005386_behavior/neurological_phenoty0.66626593
107MP0004924_abnormal_behavior0.66626593
108MP0003690_abnormal_glial_cell0.66475463
109MP0004484_altered_response_of0.64264021
110MP0004742_abnormal_vestibular_system0.63378401
111MP0003943_abnormal_hepatobiliary_system0.62218815
112MP0003646_muscle_fatigue0.61525586
113MP0000371_diluted_coat_color0.61384621
114MP0005389_reproductive_system_phenotype0.60263095
115MP0003698_abnormal_male_reproductive0.60177793
116MP0009765_abnormal_xenobiotic_induced0.60089065
117MP0002638_abnormal_pupillary_reflex0.59934548
118MP0001501_abnormal_sleep_pattern0.59517698
119MP0006054_spinal_hemorrhage0.59145583
120MP0005379_endocrine/exocrine_gland_phen0.58606473
121MP0003786_premature_aging0.58531640
122MP0005266_abnormal_metabolism0.57905685
123MP0009764_decreased_sensitivity_to0.56671354
124MP0002822_catalepsy0.56637821
125MP0005409_darkened_coat_color0.54661603
126MP0000249_abnormal_blood_vessel0.53782720
127MP0002163_abnormal_gland_morphology0.53557988
128MP0000313_abnormal_cell_death0.52317503
129MP0000350_abnormal_cell_proliferation0.50884003
130MP0003453_abnormal_keratinocyte_physiol0.50128180
131MP0002132_abnormal_respiratory_system0.49789024
132MP0004957_abnormal_blastocyst_morpholog0.47629042
133MP0001663_abnormal_digestive_system0.46656722
134MP0009763_increased_sensitivity_to0.46385591
135MP0002086_abnormal_extraembryonic_tissu0.42864552

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.71244210
2Abnormality of T cell number (HP:0011839)5.61104045
3Abnormality of the fingertips (HP:0001211)4.30427176
4Recurrent fungal infections (HP:0002841)4.30208941
5Recurrent viral infections (HP:0004429)4.21618597
6Abnormality of T cells (HP:0002843)4.19603579
7Recurrent bronchitis (HP:0002837)4.07352473
8Severe combined immunodeficiency (HP:0004430)4.03415148
9IgM deficiency (HP:0002850)3.85842171
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.76482232
11Chronic mucocutaneous candidiasis (HP:0002728)3.73887842
12Recurrent cutaneous fungal infections (HP:0011370)3.73887842
13Myositis (HP:0100614)3.66990185
14Combined immunodeficiency (HP:0005387)3.64426199
15Thyroiditis (HP:0100646)3.63317973
16Eczematoid dermatitis (HP:0000976)3.59780456
17Panhypogammaglobulinemia (HP:0003139)3.59234989
18B lymphocytopenia (HP:0010976)3.57013530
19Abnormality of B cell number (HP:0010975)3.57013530
20Stomatitis (HP:0010280)3.55948214
21Retrobulbar optic neuritis (HP:0100654)3.48171939
22Optic neuritis (HP:0100653)3.48171939
23Chronic diarrhea (HP:0002028)3.48023538
24IgG deficiency (HP:0004315)3.42298187
25Elevated erythrocyte sedimentation rate (HP:0003565)3.39595017
26Nasal polyposis (HP:0100582)3.31346422
27Stomach cancer (HP:0012126)3.30917408
28Autoimmune hemolytic anemia (HP:0001890)3.20319824
29Agammaglobulinemia (HP:0004432)3.20239434
30Autoimmune thrombocytopenia (HP:0001973)3.16737891
31Lymphopenia (HP:0001888)3.14225775
32Abnormality of eosinophils (HP:0001879)3.10754373
33IgA deficiency (HP:0002720)3.08860525
34Recurrent abscess formation (HP:0002722)3.08790132
35Chronic otitis media (HP:0000389)3.07835961
36Eosinophilia (HP:0001880)3.06490026
37Meningitis (HP:0001287)3.04680560
38Genetic anticipation (HP:0003743)3.04390961
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.03946768
40Orchitis (HP:0100796)3.03572279
41Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.02866888
42Vasculitis (HP:0002633)3.00855852
43Keratoconjunctivitis sicca (HP:0001097)2.96812721
44Abnormality of T cell physiology (HP:0011840)2.94829103
45Mediastinal lymphadenopathy (HP:0100721)2.91614816
46Abnormality of the nasal mucosa (HP:0000433)2.83958204
47Leukocytosis (HP:0001974)2.79880036
48Spontaneous hematomas (HP:0007420)2.78566032
49Pulmonary infiltrates (HP:0002113)2.78420366
50Keratoconjunctivitis (HP:0001096)2.70746665
51Renal cortical cysts (HP:0000803)2.67515115
52Granulocytopenia (HP:0001913)2.65962464
53Hypoplasia of the thymus (HP:0000778)2.63645440
54Hemoptysis (HP:0002105)2.62207766
55Abnormality of the prostate (HP:0008775)2.61040437
56Pustule (HP:0200039)2.59712968
57Neoplasm of the tracheobronchial system (HP:0100552)2.58158848
58Obstructive lung disease (HP:0006536)2.53434077
59Chronic obstructive pulmonary disease (HP:0006510)2.53434077
60Encephalitis (HP:0002383)2.53211806
61Recurrent sinusitis (HP:0011108)2.53048486
62Inflammation of the large intestine (HP:0002037)2.52448126
63Recurrent bacterial skin infections (HP:0005406)2.50866274
64Protruding tongue (HP:0010808)2.48955677
65Febrile seizures (HP:0002373)2.47061307
66Thrombocytosis (HP:0001894)2.45503012
67Truncal obesity (HP:0001956)2.45249071
68Chronic hepatic failure (HP:0100626)2.43839064
69Increased IgE level (HP:0003212)2.40975445
70Recurrent skin infections (HP:0001581)2.40921659
71Lymphoma (HP:0002665)2.40537283
72Abnormality of the renal cortex (HP:0011035)2.38865739
73Gastrointestinal inflammation (HP:0004386)2.38129748
74Arterial thrombosis (HP:0004420)2.36568523
75Acute myeloid leukemia (HP:0004808)2.26577801
76Alveolar cell carcinoma (HP:0006519)2.26034485
77Volvulus (HP:0002580)2.23792753
78Increased IgM level (HP:0003496)2.22576285
79Bronchitis (HP:0012387)2.21568549
80Progressive cerebellar ataxia (HP:0002073)2.20521728
81Papilloma (HP:0012740)2.16944917
82Verrucae (HP:0200043)2.16944917
83Joint swelling (HP:0001386)2.16294452
84Abnormality of the corticospinal tract (HP:0002492)2.16192841
85Progressive inability to walk (HP:0002505)2.15576347
86Cellulitis (HP:0100658)2.11546707
87Amyotrophic lateral sclerosis (HP:0007354)2.10666559
88Papilledema (HP:0001085)2.10637309
89Heterotopia (HP:0002282)2.09287195
90Colitis (HP:0002583)2.08619519
91Gaze-evoked nystagmus (HP:0000640)2.07791351
92Periodontitis (HP:0000704)2.07509304
93Chronic sinusitis (HP:0011109)2.05906128
94Chest pain (HP:0100749)2.04379071
95Fair hair (HP:0002286)2.04172221
96Prolonged bleeding time (HP:0003010)2.03252771
97Keratitis (HP:0000491)2.02201608
98Abnormal platelet volume (HP:0011876)2.01840040
99Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00045007
100Degeneration of the lateral corticospinal tracts (HP:0002314)2.00045007
101Menstrual irregularities (HP:0000858)1.99254810
102Excessive salivation (HP:0003781)1.94262911
103Persistence of primary teeth (HP:0006335)1.93262475
104Prominent nose (HP:0000448)1.92205851
105Ureteral obstruction (HP:0006000)1.91637291
106Absent frontal sinuses (HP:0002688)1.88970884
107Chromsome breakage (HP:0040012)1.87925250
108Hypergammaglobulinemia (HP:0010702)1.87182304
109Basal cell carcinoma (HP:0002671)1.86550773
110Tubulointerstitial nephritis (HP:0001970)1.85778396
111Slow saccadic eye movements (HP:0000514)1.84180845
112Gastrointestinal infarctions (HP:0005244)1.84068980
113Drooling (HP:0002307)1.84063481
114Epistaxis (HP:0000421)1.83616359
115Long eyelashes (HP:0000527)1.82652445
116Lip pit (HP:0100267)1.81285321
117Pulmonary embolism (HP:0002204)1.81185897
118Cheilitis (HP:0100825)1.80805590
119Viral hepatitis (HP:0006562)1.80602443
120Recurrent otitis media (HP:0000403)1.80030432
121Ureteral stenosis (HP:0000071)1.79776986
122Gingivitis (HP:0000230)1.79267653
123Abnormal hair whorl (HP:0010721)1.77436562
124Gastrointestinal stroma tumor (HP:0100723)1.77209271
125Abnormality of the pleura (HP:0002103)1.76839291
126Osteomyelitis (HP:0002754)1.76491270
127Postural instability (HP:0002172)1.76452213
128Widely spaced teeth (HP:0000687)1.76238377
129Abnormality of the columella (HP:0009929)1.76039706
130Bronchiectasis (HP:0002110)1.73216721
131Abnormality of chromosome stability (HP:0003220)1.71965149
132Anhidrosis (HP:0000970)1.70673972
133Papillary thyroid carcinoma (HP:0002895)1.68866238
134Sandal gap (HP:0001852)1.67138381
135Hypoplastic iliac wings (HP:0002866)1.65904177
136Urinary bladder sphincter dysfunction (HP:0002839)1.65081145
137Clumsiness (HP:0002312)1.64583893
138Acute hepatic failure (HP:0006554)1.64420891
139Generalized hypopigmentation of hair (HP:0011358)1.64001839
140Atonic seizures (HP:0010819)1.63022446
141Hyperventilation (HP:0002883)1.62887043

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.75506236
2MAP4K14.87733276
3JAK32.84649938
4ITK2.78643623
5MAP3K142.72951393
6CAMKK22.57713940
7CDK122.55167952
8STK102.46905065
9ZAP702.44183744
10TYK22.38359445
11IKBKE2.34506618
12FGFR32.20133496
13TEC2.11236851
14JAK12.09420434
15FGFR41.99877066
16NLK1.98557889
17IRAK41.91531296
18GRK61.86156579
19CLK11.75225355
20AKT31.60072317
21LCK1.59359435
22CSK1.58075942
23BTK1.55173177
24EEF2K1.53042512
25SYK1.49996875
26HCK1.45569083
27IKBKB1.40223040
28CHUK1.39608951
29ACVR1B1.39290669
30BMPR21.38541544
31MAP3K41.33514492
32PIM11.31360756
33EPHA31.30656709
34TGFBR21.29085074
35MAP3K131.28982133
36TBK11.26532445
37CAMKK11.25631448
38MAP3K101.23223929
39MARK31.20037797
40NUAK11.17612235
41NEK61.16284914
42ERBB31.15294123
43WNK11.12435948
44TNIK1.11332231
45PRKCQ1.09823398
46MAP4K21.09394415
47PASK1.05676782
48PIK3CG1.03761091
49SGK2231.00089660
50SGK4941.00089660
51RPS6KA40.99953851
52KIT0.99739457
53BRD40.97056387
54TNK20.94515890
55SIK20.94264195
56BMPR1B0.92772991
57STK40.91918735
58MAP2K30.91283737
59FES0.89878648
60CAMK40.86715948
61MAPK130.86454121
62CDK90.85927205
63SIK30.83219455
64TRPM70.81835092
65PRKCH0.81670075
66SGK30.80697594
67LYN0.79919049
68BCR0.79120385
69CSF1R0.78595896
70JAK20.74935055
71MAP3K70.74277801
72STK380.73872836
73INSRR0.72031998
74ATR0.71540068
75MELK0.71155065
76CDK60.70983139
77CDK40.70786352
78YES10.70516830
79TYRO30.69581263
80PIK3CA0.69295535
81SGK20.68886798
82DYRK1A0.68163721
83MARK20.67311553
84STK240.65143510
85CDC70.63200150
86LRRK20.63003344
87MST40.62905486
88NTRK20.61225758
89SGK10.60055268
90PAK30.59549235
91MKNK20.58683267
92EGFR0.57928393
93TLK10.57560831
94BLK0.56869865
95EIF2AK30.56403935
96MAP2K70.55899188
97RIPK40.55132647
98RAF10.53915556
99CAMK1G0.53836619
100FRK0.53378381
101PRPF4B0.53078248
102TGFBR10.52752366
103RPS6KA50.52500423
104PTK2B0.52206007
105STK110.51188508
106TAOK30.49430852
107RET0.49363343
108IGF1R0.48574806
109RPS6KB10.48067176
110ADRBK20.48006242
111MAPK70.47811082
112MAPK110.46453528
113HIPK20.46368568
114SRPK10.46220555
115CDK30.46089799
116MARK10.45782301
117ZAK0.45649596
118TTN0.44654453
119FGR0.43226757
120ATM0.42344874
121CAMK1D0.41031053
122RPS6KB20.40453257
123CASK0.39746532
124PINK10.39679830
125DMPK0.39441588
126EPHB10.39066981
127INSR0.37502911
128PDGFRB0.36894199
129FGFR20.36450564
130CHEK10.35374620
131IRAK10.34418348
132MAP3K120.34356457
133PRKD20.32325063
134PRKAA20.31136148
135KDR0.29641568
136EIF2AK20.27699995
137PDK10.27594999
138ALK0.26174813
139ABL10.25466276
140MAPKAPK20.25172935
141MKNK10.25043345
142MAP2K60.25013272
143MAPK30.24176567

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.21549205
2T cell receptor signaling pathway_Homo sapiens_hsa046602.87348950
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.70066943
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.58833661
5Allograft rejection_Homo sapiens_hsa053302.55633143
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.55184291
7Measles_Homo sapiens_hsa051622.34509885
8Autoimmune thyroid disease_Homo sapiens_hsa053202.22266403
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.19051634
10Graft-versus-host disease_Homo sapiens_hsa053322.13180411
11Leishmaniasis_Homo sapiens_hsa051402.02916609
12Hematopoietic cell lineage_Homo sapiens_hsa046401.99141339
13B cell receptor signaling pathway_Homo sapiens_hsa046621.93101077
14Osteoclast differentiation_Homo sapiens_hsa043801.91802245
15Antigen processing and presentation_Homo sapiens_hsa046121.83755773
16Herpes simplex infection_Homo sapiens_hsa051681.68040684
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.62853678
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61413280
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.55844304
20Asthma_Homo sapiens_hsa053101.51015338
21Toxoplasmosis_Homo sapiens_hsa051451.40005525
22Viral myocarditis_Homo sapiens_hsa054161.38742118
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33324879
24Chemokine signaling pathway_Homo sapiens_hsa040621.32457945
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.29315944
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28385812
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.27182592
28Influenza A_Homo sapiens_hsa051641.26570114
29Hepatitis B_Homo sapiens_hsa051611.23986813
30TNF signaling pathway_Homo sapiens_hsa046681.22785331
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20264187
32Non-homologous end-joining_Homo sapiens_hsa034501.18603919
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15429798
34Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15305687
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.14309788
36Acute myeloid leukemia_Homo sapiens_hsa052211.10025958
37Type I diabetes mellitus_Homo sapiens_hsa049401.08529847
38HTLV-I infection_Homo sapiens_hsa051661.07106752
39Type II diabetes mellitus_Homo sapiens_hsa049301.05321368
40ErbB signaling pathway_Homo sapiens_hsa040121.03744956
41Apoptosis_Homo sapiens_hsa042101.02186326
42Pancreatic cancer_Homo sapiens_hsa052121.00026296
43Nicotine addiction_Homo sapiens_hsa050330.98602556
44Chronic myeloid leukemia_Homo sapiens_hsa052200.97599043
45Platelet activation_Homo sapiens_hsa046110.95435786
46Circadian rhythm_Homo sapiens_hsa047100.95336113
47Shigellosis_Homo sapiens_hsa051310.94589057
48Renal cell carcinoma_Homo sapiens_hsa052110.93819173
49Tuberculosis_Homo sapiens_hsa051520.89644098
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88216388
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87800840
52Viral carcinogenesis_Homo sapiens_hsa052030.87535577
53Cholinergic synapse_Homo sapiens_hsa047250.87286600
54Regulation of autophagy_Homo sapiens_hsa041400.87216340
55Taste transduction_Homo sapiens_hsa047420.86638016
56Morphine addiction_Homo sapiens_hsa050320.86509108
57Prolactin signaling pathway_Homo sapiens_hsa049170.85155722
58Epstein-Barr virus infection_Homo sapiens_hsa051690.84332807
59Long-term potentiation_Homo sapiens_hsa047200.84264466
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83772930
61Basal transcription factors_Homo sapiens_hsa030220.83575948
62Small cell lung cancer_Homo sapiens_hsa052220.83572272
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82490460
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81888309
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80296111
66p53 signaling pathway_Homo sapiens_hsa041150.79140412
67Hepatitis C_Homo sapiens_hsa051600.77954438
68Colorectal cancer_Homo sapiens_hsa052100.76907581
69Malaria_Homo sapiens_hsa051440.76902059
70Inositol phosphate metabolism_Homo sapiens_hsa005620.74405889
71Adherens junction_Homo sapiens_hsa045200.72297504
72Legionellosis_Homo sapiens_hsa051340.71982147
73FoxO signaling pathway_Homo sapiens_hsa040680.71673844
74Fanconi anemia pathway_Homo sapiens_hsa034600.71320593
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.70553216
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70177040
77mRNA surveillance pathway_Homo sapiens_hsa030150.69835413
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68641079
79Pertussis_Homo sapiens_hsa051330.67623919
80RNA degradation_Homo sapiens_hsa030180.67345677
81Salmonella infection_Homo sapiens_hsa051320.65998895
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65363295
83Non-small cell lung cancer_Homo sapiens_hsa052230.65320049
84Systemic lupus erythematosus_Homo sapiens_hsa053220.64974726
85Glioma_Homo sapiens_hsa052140.64588112
86Olfactory transduction_Homo sapiens_hsa047400.62070510
87Ras signaling pathway_Homo sapiens_hsa040140.61786510
88MicroRNAs in cancer_Homo sapiens_hsa052060.61216167
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.59838301
90African trypanosomiasis_Homo sapiens_hsa051430.59522820
91Base excision repair_Homo sapiens_hsa034100.59214287
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58713247
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58144282
94Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57512837
95MAPK signaling pathway_Homo sapiens_hsa040100.56859933
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55387913
97Cell cycle_Homo sapiens_hsa041100.55013577
98DNA replication_Homo sapiens_hsa030300.54949276
99Homologous recombination_Homo sapiens_hsa034400.54753438
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.54574757
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54283506
102Glutamatergic synapse_Homo sapiens_hsa047240.54238242
103Phototransduction_Homo sapiens_hsa047440.53588155
104Spliceosome_Homo sapiens_hsa030400.52861023
105VEGF signaling pathway_Homo sapiens_hsa043700.52495489
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52230835
107Prostate cancer_Homo sapiens_hsa052150.52156352
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51781022
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50287233
110Amphetamine addiction_Homo sapiens_hsa050310.48838522
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48762595
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46281909
113Lysine degradation_Homo sapiens_hsa003100.44586453
114Endometrial cancer_Homo sapiens_hsa052130.44228554
115Mismatch repair_Homo sapiens_hsa034300.42702088
116Notch signaling pathway_Homo sapiens_hsa043300.42129790
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41240712
118Pathways in cancer_Homo sapiens_hsa052000.40772162
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.40487006
120ABC transporters_Homo sapiens_hsa020100.38850001
121Thyroid cancer_Homo sapiens_hsa052160.38185490
122Staphylococcus aureus infection_Homo sapiens_hsa051500.37450126
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.37237679
124Rheumatoid arthritis_Homo sapiens_hsa053230.37018277
125Dorso-ventral axis formation_Homo sapiens_hsa043200.34677944
126RNA transport_Homo sapiens_hsa030130.33661163
127Choline metabolism in cancer_Homo sapiens_hsa052310.32764014
128mTOR signaling pathway_Homo sapiens_hsa041500.32452233
129Insulin resistance_Homo sapiens_hsa049310.31416172
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31302301

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