RAPGEF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.85089362
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70174171
3locomotory exploration behavior (GO:0035641)5.61264037
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.60009113
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.99803768
6synaptic vesicle docking involved in exocytosis (GO:0016081)4.98212868
7central nervous system myelination (GO:0022010)4.91310059
8axon ensheathment in central nervous system (GO:0032291)4.91310059
9glutamate secretion (GO:0014047)4.89234858
10amino acid import (GO:0043090)4.86814118
11synaptic vesicle exocytosis (GO:0016079)4.75150008
12vocalization behavior (GO:0071625)4.72445102
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.63314302
14negative regulation of synaptic transmission, GABAergic (GO:0032229)4.54779468
15regulation of synaptic vesicle exocytosis (GO:2000300)4.54441741
16regulation of neuronal synaptic plasticity (GO:0048168)4.52850341
17regulation of glutamate receptor signaling pathway (GO:1900449)4.50334002
18regulation of synapse structural plasticity (GO:0051823)4.46490188
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.44340103
20neuronal action potential propagation (GO:0019227)4.43836169
21neurotransmitter secretion (GO:0007269)4.32987179
22potassium ion homeostasis (GO:0055075)4.32459019
23potassium ion import (GO:0010107)4.31648185
24cerebellar granule cell differentiation (GO:0021707)4.26350611
25neurotransmitter-gated ion channel clustering (GO:0072578)4.21528729
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.14883868
27regulation of synaptic vesicle transport (GO:1902803)4.14165406
28gamma-aminobutyric acid transport (GO:0015812)4.09873867
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.05845256
30postsynaptic membrane organization (GO:0001941)4.04934546
31ionotropic glutamate receptor signaling pathway (GO:0035235)3.98289127
32exploration behavior (GO:0035640)3.97311975
33cellular sodium ion homeostasis (GO:0006883)3.87738813
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.86945715
35protein localization to synapse (GO:0035418)3.80948901
36dendritic spine morphogenesis (GO:0060997)3.78738791
37neurotransmitter uptake (GO:0001504)3.72973025
38synaptic transmission, glutamatergic (GO:0035249)3.71926516
39long-term memory (GO:0007616)3.71327082
40positive regulation of membrane potential (GO:0045838)3.69750518
41negative regulation of dendrite morphogenesis (GO:0050774)3.69522128
42regulation of dendritic spine morphogenesis (GO:0061001)3.66472593
43prepulse inhibition (GO:0060134)3.66054309
44acidic amino acid transport (GO:0015800)3.61932772
45positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.60857078
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.59733308
47regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.58478784
48activation of protein kinase A activity (GO:0034199)3.57741738
49neuron-neuron synaptic transmission (GO:0007270)3.57421277
50positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56191810
51layer formation in cerebral cortex (GO:0021819)3.55668694
52neuromuscular process controlling balance (GO:0050885)3.53239359
53regulation of synapse maturation (GO:0090128)3.52428506
54regulation of synaptic plasticity (GO:0048167)3.44319616
55neuromuscular process controlling posture (GO:0050884)3.37297663
56presynaptic membrane organization (GO:0097090)3.37169318
57glutamate receptor signaling pathway (GO:0007215)3.36985949
58neurotransmitter transport (GO:0006836)3.36454680
59regulation of postsynaptic membrane potential (GO:0060078)3.33398404
60presynaptic membrane assembly (GO:0097105)3.32554638
61auditory behavior (GO:0031223)3.28642972
62regulation of neurotransmitter levels (GO:0001505)3.27509341
63glycine transport (GO:0015816)3.26254088
64cellular potassium ion homeostasis (GO:0030007)3.26021278
65proline transport (GO:0015824)3.25914538
66positive regulation of neurotransmitter transport (GO:0051590)3.24777824
67positive regulation of dendritic spine morphogenesis (GO:0061003)3.24359515
68G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21206445
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.17569829
70behavioral response to cocaine (GO:0048148)3.17422578
71L-glutamate transport (GO:0015813)3.17228693
72transmission of nerve impulse (GO:0019226)3.15632053
73long-term synaptic potentiation (GO:0060291)3.13992433
74positive regulation of neurotransmitter secretion (GO:0001956)3.12951262
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.12794004
76positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.12138180
77regulation of ARF protein signal transduction (GO:0032012)3.11356081
78sodium ion export (GO:0071436)3.09732685
79response to auditory stimulus (GO:0010996)3.07848304
80neuronal ion channel clustering (GO:0045161)3.04429483
81detection of calcium ion (GO:0005513)3.04315853
82regulation of neurotransmitter secretion (GO:0046928)3.03670408
83neuromuscular synaptic transmission (GO:0007274)3.02571781
84regulation of female receptivity (GO:0045924)3.02178990
85neuron cell-cell adhesion (GO:0007158)3.02121025
86synaptic vesicle transport (GO:0048489)3.01109899
87establishment of synaptic vesicle localization (GO:0097480)3.01109899
88positive regulation of dendrite development (GO:1900006)2.99932880
89phosphorelay signal transduction system (GO:0000160)2.98235693
90regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.96525938
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.94416783
92regulation of dendritic spine development (GO:0060998)2.94258817
93L-amino acid import (GO:0043092)2.94061092
94C4-dicarboxylate transport (GO:0015740)2.93645566
95vesicle docking involved in exocytosis (GO:0006904)2.93555424
96regulation of neurotransmitter transport (GO:0051588)2.93446646
97serotonin metabolic process (GO:0042428)2.91945810
98membrane depolarization during action potential (GO:0086010)2.87590367
99membrane depolarization (GO:0051899)2.87107494
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86622931
101positive regulation of synaptic transmission (GO:0050806)2.85044701
102striatum development (GO:0021756)2.84773791
103cerebellar Purkinje cell differentiation (GO:0021702)2.84650280
104membrane hyperpolarization (GO:0060081)2.80922506
105dendritic spine organization (GO:0097061)2.80850509
106neuromuscular process (GO:0050905)2.79597754
107regulation of vesicle fusion (GO:0031338)2.77444264
108positive regulation of dendritic spine development (GO:0060999)2.75862653
109synaptic vesicle endocytosis (GO:0048488)2.74420740
110synaptic transmission, dopaminergic (GO:0001963)2.74301867
111dendrite morphogenesis (GO:0048813)2.72803217
112vesicle transport along microtubule (GO:0047496)2.72613902
113regulation of synaptic transmission (GO:0050804)2.72222608
114regulation of voltage-gated calcium channel activity (GO:1901385)2.72217495
115adenosine receptor signaling pathway (GO:0001973)2.71391121
116dicarboxylic acid biosynthetic process (GO:0043650)2.71025382
117long term synaptic depression (GO:0060292)2.70570610
118learning (GO:0007612)2.69122179
119chemosensory behavior (GO:0007635)2.67007300
120cell communication by electrical coupling (GO:0010644)2.66674340
121female mating behavior (GO:0060180)2.65961853
122positive regulation of synapse maturation (GO:0090129)2.65307092
123visual learning (GO:0008542)2.64861878
124regulation of glutamate secretion (GO:0014048)2.64665147
125negative regulation of dendrite development (GO:2000171)2.64582107
126adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.63428088
127mating behavior (GO:0007617)2.63324229
128alanine transport (GO:0032328)2.63254180
129synaptic transmission (GO:0007268)2.62258090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.91455535
2RARB_27405468_Chip-Seq_BRAIN_Mouse2.98224664
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.83306592
4GBX2_23144817_ChIP-Seq_PC3_Human2.82108520
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.80736434
6DROSHA_22980978_ChIP-Seq_HELA_Human2.69511995
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.61630596
8REST_21632747_ChIP-Seq_MESCs_Mouse2.58440405
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50082116
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50082116
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43850871
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41649673
13* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41419578
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.37600305
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34360749
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24448596
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21086065
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.17142153
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07865475
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.05924605
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.02864263
22EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.00188007
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.90314507
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.89243014
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.87307510
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83156471
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.79785158
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78283362
29AR_21572438_ChIP-Seq_LNCaP_Human1.70637086
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70444250
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55400186
32CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54879360
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48495353
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42318702
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39756021
36SMAD4_21799915_ChIP-Seq_A2780_Human1.39206404
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.35093548
38RXR_22158963_ChIP-Seq_LIVER_Mouse1.34386914
39* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.32348005
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31123220
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29900162
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25741473
43TAF15_26573619_Chip-Seq_HEK293_Human1.24655309
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24291104
45WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23990929
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.23952049
47KDM2B_26808549_Chip-Seq_K562_Human1.23590445
48RNF2_27304074_Chip-Seq_NSC_Mouse1.22408622
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.21331791
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21025392
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18571505
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18327263
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.18296459
54* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17155565
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17057420
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.16879843
57* AR_19668381_ChIP-Seq_PC3_Human1.15764409
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.12278144
59* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11740992
60* STAT3_23295773_ChIP-Seq_U87_Human1.11024480
61GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10399476
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09366524
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.06345301
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03613382
65* AR_25329375_ChIP-Seq_VCAP_Human1.01604429
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00899881
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00567182
68BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.00014373
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99525404
70ESR2_21235772_ChIP-Seq_MCF-7_Human0.99507551
71P300_19829295_ChIP-Seq_ESCs_Human0.99442850
72PIAS1_25552417_ChIP-Seq_VCAP_Human0.99336660
73ZFP281_18757296_ChIP-ChIP_E14_Mouse0.98832639
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96122330
75SMAD4_21741376_ChIP-Seq_HESCs_Human0.95938754
76* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95724662
77SMAD3_21741376_ChIP-Seq_HESCs_Human0.95471105
78CTCF_27219007_Chip-Seq_Bcells_Human0.94955638
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.94867387
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94558020
81* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93620862
82* TCF4_23295773_ChIP-Seq_U87_Human0.93020519
83* P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92919675
84RING1B_27294783_Chip-Seq_NPCs_Mouse0.92751088
85CDX2_19796622_ChIP-Seq_MESCs_Mouse0.92233079
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92204983
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91497494
88SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91453668
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.91070650
90AHR_22903824_ChIP-Seq_MCF-7_Human0.90702146
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.90488141
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.90193363
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89778655
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.89503826
95RXR_22108803_ChIP-Seq_LS180_Human0.89161575
96* FOXA2_19822575_ChIP-Seq_HepG2_Human0.88544555
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88419796
98KLF4_19829295_ChIP-Seq_ESCs_Human0.88008825
99* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.87940346
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87759403
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.87377237
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86861476
103BMI1_23680149_ChIP-Seq_NPCS_Mouse0.86548968
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.86476144
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86142290
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85785891
107YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84934885
108ZNF274_21170338_ChIP-Seq_K562_Hela0.84536321
109TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83080084
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.82790762
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.82157178
112ESR1_20079471_ChIP-ChIP_T-47D_Human0.81811223
113ZFP57_27257070_Chip-Seq_ESCs_Mouse0.81485246
114SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81054573
115OCT4_19829295_ChIP-Seq_ESCs_Human0.80094768
116DPY_21335234_ChIP-Seq_ESCs_Mouse0.78830182
117CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77763247
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.76628341
119* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76511103

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.78064528
2MP0002822_catalepsy5.10669433
3MP0003635_abnormal_synaptic_transmissio4.01765978
4MP0003880_abnormal_central_pattern3.96850463
5MP0004270_analgesia3.57996351
6MP0009745_abnormal_behavioral_response3.37774485
7MP0002063_abnormal_learning/memory/cond3.22422079
8MP0002064_seizures3.05058618
9MP0009046_muscle_twitch2.80972610
10MP0002572_abnormal_emotion/affect_behav2.58614463
11MP0001486_abnormal_startle_reflex2.54728562
12MP0001968_abnormal_touch/_nociception2.53896367
13MP0002272_abnormal_nervous_system2.47222863
14MP0005423_abnormal_somatic_nervous2.35000352
15MP0002734_abnormal_mechanical_nocicepti2.28537807
16MP0002909_abnormal_adrenal_gland2.23598475
17MP0005085_abnormal_gallbladder_physiolo2.18037373
18MP0001501_abnormal_sleep_pattern2.17125911
19MP0009780_abnormal_chondrocyte_physiolo2.15568076
20MP0002139_abnormal_hepatobiliary_system2.05197517
21MP0005646_abnormal_pituitary_gland1.86515834
22MP0003329_amyloid_beta_deposits1.85150998
23MP0008569_lethality_at_weaning1.84430468
24MP0005360_urolithiasis1.80005368
25MP0002736_abnormal_nociception_after1.75177612
26MP0001440_abnormal_grooming_behavior1.66290276
27MP0002733_abnormal_thermal_nociception1.65361014
28MP0001970_abnormal_pain_threshold1.64366162
29MP0004811_abnormal_neuron_physiology1.62485645
30MP0002735_abnormal_chemical_nociception1.59802858
31MP0005365_abnormal_bile_salt1.57445352
32MP0003879_abnormal_hair_cell1.56779054
33MP0005386_behavior/neurological_phenoty1.56708295
34MP0004924_abnormal_behavior1.56708295
35MP0003633_abnormal_nervous_system1.56322890
36MP0002067_abnormal_sensory_capabilities1.54767292
37MP0002557_abnormal_social/conspecific_i1.50064259
38MP0004858_abnormal_nervous_system1.48069679
39MP0008875_abnormal_xenobiotic_pharmacok1.47719435
40MP0003075_altered_response_to1.41483409
41MP0004885_abnormal_endolymph1.41054785
42MP0003690_abnormal_glial_cell1.33013837
43MP0005167_abnormal_blood-brain_barrier1.32678321
44MP0000955_abnormal_spinal_cord1.32452536
45MP0002066_abnormal_motor_capabilities/c1.26929696
46MP0008874_decreased_physiological_sensi1.26020600
47MP0008872_abnormal_physiological_respon1.25442878
48MP0001984_abnormal_olfaction1.24794497
49MP0002184_abnormal_innervation1.23065408
50MP0003631_nervous_system_phenotype1.22712860
51MP0005535_abnormal_body_temperature1.21469917
52MP0000013_abnormal_adipose_tissue1.19264526
53MP0001485_abnormal_pinna_reflex1.18984204
54MP0010329_abnormal_lipoprotein_level1.17446290
55MP0004742_abnormal_vestibular_system1.16216089
56MP0001177_atelectasis1.15508641
57MP0003123_paternal_imprinting1.12818137
58MP0001529_abnormal_vocalization1.12257864
59MP0003252_abnormal_bile_duct1.09585747
60MP0001963_abnormal_hearing_physiology1.09573408
61MP0002882_abnormal_neuron_morphology1.09170448
62MP0008961_abnormal_basal_metabolism1.08841673
63MP0001502_abnormal_circadian_rhythm1.08720236
64MP0003122_maternal_imprinting1.07446677
65MP0000604_amyloidosis1.07280920
66MP0003195_calcinosis1.01295640
67MP0003283_abnormal_digestive_organ1.01124149
68MP0000778_abnormal_nervous_system1.00568470
69MP0004043_abnormal_pH_regulation1.00297551
70MP0002069_abnormal_eating/drinking_beha0.98874271
71MP0002638_abnormal_pupillary_reflex0.98217350
72MP0001986_abnormal_taste_sensitivity0.97528237
73MP0000920_abnormal_myelination0.94452202
74MP0004142_abnormal_muscle_tone0.93608384
75MP0002090_abnormal_vision0.92396244
76MP0001905_abnormal_dopamine_level0.92178464
77MP0010234_abnormal_vibrissa_follicle0.91389785
78MP0004147_increased_porphyrin_level0.90412502
79MP0005645_abnormal_hypothalamus_physiol0.88988409
80MP0002229_neurodegeneration0.86671221
81MP0004085_abnormal_heartbeat0.86462310
82MP0006276_abnormal_autonomic_nervous0.83094159
83MP0003787_abnormal_imprinting0.80098531
84MP0002152_abnormal_brain_morphology0.79359108
85MP0002118_abnormal_lipid_homeostasis0.78590001
86MP0003632_abnormal_nervous_system0.77764493
87MP0008877_abnormal_DNA_methylation0.75268013
88MP0005584_abnormal_enzyme/coenzyme_acti0.73419718
89MP0005332_abnormal_amino_acid0.70927280
90MP0005409_darkened_coat_color0.69805324
91MP0004130_abnormal_muscle_cell0.69522701
92MP0005083_abnormal_biliary_tract0.68063417
93MP0002837_dystrophic_cardiac_calcinosis0.67483648
94MP0001666_abnormal_nutrient_absorption0.66889189
95MP0005551_abnormal_eye_electrophysiolog0.65822120
96MP0003137_abnormal_impulse_conducting0.65169564
97MP0002752_abnormal_somatic_nervous0.64721422
98MP0000569_abnormal_digit_pigmentation0.64458553
99MP0003634_abnormal_glial_cell0.64392431
100MP0002078_abnormal_glucose_homeostasis0.63047667
101MP0005166_decreased_susceptibility_to0.62800275
102MP0000631_abnormal_neuroendocrine_gland0.61946250
103MP0003172_abnormal_lysosome_physiology0.61845540
104MP0001346_abnormal_lacrimal_gland0.61567255
105MP0000751_myopathy0.60848099
106MP0001765_abnormal_ion_homeostasis0.59285188
107MP0002876_abnormal_thyroid_physiology0.58084265
108MP0003183_abnormal_peptide_metabolism0.56325143
109MP0010386_abnormal_urinary_bladder0.56199918
110MP0000026_abnormal_inner_ear0.56160472
111MP0003868_abnormal_feces_composition0.54836292
112MP0001664_abnormal_digestion0.54596268
113MP0000639_abnormal_adrenal_gland0.54537399
114MP0004215_abnormal_myocardial_fiber0.53413810
115MP0001188_hyperpigmentation0.52769311
116MP0010769_abnormal_survival0.52236644
117MP0005448_abnormal_energy_balance0.52232346
118MP0003953_abnormal_hormone_level0.51047965
119MP0010768_mortality/aging0.48987435
120MP0003938_abnormal_ear_development0.48641947
121MP0005623_abnormal_meninges_morphology0.48506444
122MP0010770_preweaning_lethality0.47843648
123MP0002082_postnatal_lethality0.47843648
124MP0003956_abnormal_body_size0.46739055
125MP0001943_abnormal_respiration0.46364227
126MP0001299_abnormal_eye_distance/0.43956038
127MP0000579_abnormal_nail_morphology0.42286080

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.62823782
2Focal motor seizures (HP:0011153)7.26542401
3Focal seizures (HP:0007359)5.31575329
4Visual hallucinations (HP:0002367)4.48624184
5Action tremor (HP:0002345)4.13900332
6Atonic seizures (HP:0010819)3.83852194
7Epileptic encephalopathy (HP:0200134)3.79200022
8Febrile seizures (HP:0002373)3.76496087
9Generalized tonic-clonic seizures (HP:0002069)3.74151161
10Impaired vibration sensation in the lower limbs (HP:0002166)3.72902561
11Absence seizures (HP:0002121)3.62725620
12Ankle clonus (HP:0011448)3.57897723
13Poor eye contact (HP:0000817)3.55786270
14Progressive cerebellar ataxia (HP:0002073)3.46880065
15Torticollis (HP:0000473)3.45994434
16Abnormal social behavior (HP:0012433)3.38246153
17Impaired social interactions (HP:0000735)3.38246153
18Limb dystonia (HP:0002451)3.36417344
19Depression (HP:0000716)3.33158482
20Dialeptic seizures (HP:0011146)3.30974445
21Anxiety (HP:0000739)3.29764156
22Dysdiadochokinesis (HP:0002075)3.27492943
23Postural instability (HP:0002172)3.26244637
24Urinary bladder sphincter dysfunction (HP:0002839)3.25686782
25Gaze-evoked nystagmus (HP:0000640)3.22377239
26Obstructive sleep apnea (HP:0002870)3.20463350
27Focal dystonia (HP:0004373)3.18660226
28Cerebral hypomyelination (HP:0006808)3.13608860
29Dysmetria (HP:0001310)3.11397177
30Papilledema (HP:0001085)3.10644709
31Status epilepticus (HP:0002133)3.05724254
32Abnormality of the lower motor neuron (HP:0002366)3.03171161
33Supranuclear gaze palsy (HP:0000605)3.02093709
34Intention tremor (HP:0002080)2.97840659
35Abnormality of the corticospinal tract (HP:0002492)2.96877259
36Craniofacial dystonia (HP:0012179)2.96647524
37Scanning speech (HP:0002168)2.89732277
38Delusions (HP:0000746)2.87310109
39Broad-based gait (HP:0002136)2.86405550
40Hyperventilation (HP:0002883)2.85167748
41Urinary urgency (HP:0000012)2.80567268
42Annular pancreas (HP:0001734)2.79622727
43Impaired vibratory sensation (HP:0002495)2.77420177
44Increased circulating renin level (HP:0000848)2.75045750
45Spastic gait (HP:0002064)2.74064872
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.73282188
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.73282188
48Deep venous thrombosis (HP:0002625)2.73128419
49Dysmetric saccades (HP:0000641)2.69602080
50Resting tremor (HP:0002322)2.65457607
51Peripheral hypomyelination (HP:0007182)2.63491435
52Abnormal eating behavior (HP:0100738)2.61303372
53Truncal ataxia (HP:0002078)2.57864312
54Hemiplegia (HP:0002301)2.56843395
55Impaired smooth pursuit (HP:0007772)2.56676209
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.55458086
57Akinesia (HP:0002304)2.52037484
58Ventricular fibrillation (HP:0001663)2.50282358
59Sleep apnea (HP:0010535)2.48290218
60Bradykinesia (HP:0002067)2.47111331
61Neurofibrillary tangles (HP:0002185)2.46029495
62Bundle branch block (HP:0011710)2.43887533
63Clonus (HP:0002169)2.41515658
64Stereotypic behavior (HP:0000733)2.35478578
65Abnormality of the periventricular white matter (HP:0002518)2.35432615
66Amblyopia (HP:0000646)2.35319091
67Tetraplegia (HP:0002445)2.31524551
68Apathy (HP:0000741)2.26110498
69Blue irides (HP:0000635)2.25815855
70Intrahepatic cholestasis (HP:0001406)2.24804122
71Hemiparesis (HP:0001269)2.24443925
72Epileptiform EEG discharges (HP:0011182)2.24310587
73Genetic anticipation (HP:0003743)2.23161509
74Abnormality of ocular smooth pursuit (HP:0000617)2.22687521
75EEG with generalized epileptiform discharges (HP:0011198)2.21157687
76Cerebral inclusion bodies (HP:0100314)2.20894960
77Hypsarrhythmia (HP:0002521)2.18395361
78Megalencephaly (HP:0001355)2.18209321
79Choreoathetosis (HP:0001266)2.16526490
80Polyphagia (HP:0002591)2.16228092
81Morphological abnormality of the pyramidal tract (HP:0002062)2.13770545
82Generalized myoclonic seizures (HP:0002123)2.10544630
83Mutism (HP:0002300)2.07709620
84Split foot (HP:0001839)2.07192671
85Lower limb muscle weakness (HP:0007340)2.05645314
86Hyperlipoproteinemia (HP:0010980)2.04732352
87Xanthomatosis (HP:0000991)2.04252508
88Complement deficiency (HP:0004431)2.03882284
89Ankyloglossia (HP:0010296)2.02860937
90CNS hypomyelination (HP:0003429)2.01786038
91Abnormality of saccadic eye movements (HP:0000570)2.01282700
92Diminished motivation (HP:0000745)2.01089696
93Aplasia involving bones of the upper limbs (HP:0009823)1.99021765
94Aplasia of the phalanges of the hand (HP:0009802)1.99021765
95Aplasia involving bones of the extremities (HP:0009825)1.99021765
96Pheochromocytoma (HP:0002666)1.97333336
97Pointed chin (HP:0000307)1.96120776
98Prolonged partial thromboplastin time (HP:0003645)1.95973492
99Insomnia (HP:0100785)1.94932925
100Rigidity (HP:0002063)1.93139476
101Spastic tetraparesis (HP:0001285)1.92552251
102Insidious onset (HP:0003587)1.90207872
103Termporal pattern (HP:0011008)1.90207872
104Excessive salivation (HP:0003781)1.90014534
105Drooling (HP:0002307)1.90014534
106Heart block (HP:0012722)1.89552937
107Delayed CNS myelination (HP:0002188)1.89342278
108Gait ataxia (HP:0002066)1.88614865
109Progressive inability to walk (HP:0002505)1.88499545
110Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87742938
111Agitation (HP:0000713)1.87199849
112Spinal canal stenosis (HP:0003416)1.86468004
113Abnormality of binocular vision (HP:0011514)1.86389810
114Diplopia (HP:0000651)1.86389810
115Neuronal loss in central nervous system (HP:0002529)1.85248038
116Absent speech (HP:0001344)1.83936943
117Rapidly progressive (HP:0003678)1.82582544
118Incomplete penetrance (HP:0003829)1.82006194
119Ketosis (HP:0001946)1.81614579
120Syncope (HP:0001279)1.81125639
121Neonatal onset (HP:0003623)1.79768225
122Atrioventricular block (HP:0001678)1.78340618
123Abnormality of monocarboxylic acid metabolism (HP:0010996)1.77698573
124Polygenic inheritance (HP:0010982)1.77528310
125Abnormal EKG (HP:0003115)1.77473926
126Lower limb amyotrophy (HP:0007210)1.77007363
127Lower limb asymmetry (HP:0100559)1.74108507
128Prolonged QT interval (HP:0001657)1.70717850
129Confusion (HP:0001289)1.69992881
130Thickened helices (HP:0000391)1.69494651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.71064854
2NTRK34.24164917
3MAP3K93.64189963
4DAPK23.31944062
5PRKD33.01215218
6KSR22.51364987
7MAP3K42.46721047
8CAMKK12.41187407
9MINK12.35451743
10PAK62.17829711
11NTRK12.08218705
12MAP2K41.94553252
13RIPK41.92977423
14MAP2K71.89096388
15MARK11.80957127
16NTRK21.77379672
17MAP3K21.62694719
18DAPK11.61820679
19STK381.55799588
20MAP3K131.55241234
21CDK51.54015961
22PINK11.49595246
23KSR11.37869147
24TYRO31.36790559
25TAOK11.36182069
26FES1.33622020
27PRPF4B1.32195267
28ARAF1.32020293
29TNIK1.24461755
30CAMKK21.23671002
31PRKCH1.18513907
32SGK2231.12438160
33SGK4941.12438160
34PRKCG1.12163444
35SIK21.10486805
36UHMK11.06126130
37SGK30.99957319
38GRK50.99804462
39SGK20.99490508
40RET0.99316746
41CAMK10.99096542
42CDK190.98008431
43MAP3K120.97823113
44STK110.95779558
45MAP3K10.92087211
46RIPK10.90289629
47PDK10.88157448
48PDPK10.87930476
49MAPK120.86432590
50RAF10.84042697
51PTK2B0.81731734
52CAMK2A0.79361117
53ALK0.77667363
54BMPR20.75268580
55SGK10.74745009
56MAPK130.72136474
57PKN10.71585075
58LMTK20.70096695
59MAP3K70.68928816
60TNK20.68759795
61CDK150.68258872
62MARK20.67927927
63CAMK2B0.67875307
64CDK180.67133587
65INSRR0.65688410
66PAK30.64867997
67FGFR20.63803729
68CDK140.62666365
69PLK20.61723776
70CAMK40.60349875
71NEK60.58997363
72BRSK10.58782079
73PRKCZ0.58450344
74WNK10.58370875
75RPS6KA30.57834391
76CDK11A0.57177733
77CDC42BPA0.56544851
78PHKG10.56408288
79PHKG20.56408288
80CAMK2G0.53340362
81CASK0.53244109
82LIMK10.52044222
83MAP2K10.51176015
84OXSR10.50779288
85TRIB30.49736952
86NEK10.49383979
87DAPK30.49279822
88STK390.47788157
89MAP3K110.45870637
90BRAF0.45579735
91FYN0.45162555
92MAPK100.44823584
93ROCK20.44481482
94PDGFRA0.43198001
95CSNK1G20.42875880
96CAMK1G0.42149494
97LATS20.39415861
98PRKG20.39353034
99PRKCE0.37743642
100PRKD20.37740565
101MAPKAPK50.37535427
102CAMK2D0.36957016
103DYRK1A0.36228328
104ROCK10.35774854
105MAP2K60.34323739
106PNCK0.33992189
107PRKACG0.33953102
108PRKCB0.33436806
109PRKG10.33392426
110PRKCA0.31643334
111ERBB20.31353018
112PRKACA0.30888256
113CSNK1A10.28779184
114PRKD10.28604722
115CSNK1D0.28290516
116SCYL20.27800169

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.96733658
2Nicotine addiction_Homo sapiens_hsa050332.70936911
3Olfactory transduction_Homo sapiens_hsa047402.68148113
4Synaptic vesicle cycle_Homo sapiens_hsa047212.65208434
5GABAergic synapse_Homo sapiens_hsa047272.44403438
6Circadian entrainment_Homo sapiens_hsa047132.35287454
7Glutamatergic synapse_Homo sapiens_hsa047242.25669478
8Long-term potentiation_Homo sapiens_hsa047202.21589869
9Morphine addiction_Homo sapiens_hsa050322.21357716
10Amphetamine addiction_Homo sapiens_hsa050312.20693622
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14299353
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12320028
13Vitamin B6 metabolism_Homo sapiens_hsa007502.05827217
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.92010044
15Arginine biosynthesis_Homo sapiens_hsa002201.92008761
16Dopaminergic synapse_Homo sapiens_hsa047281.84983365
17* Insulin secretion_Homo sapiens_hsa049111.81795360
18Salivary secretion_Homo sapiens_hsa049701.81355615
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80366041
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78549057
21Cholinergic synapse_Homo sapiens_hsa047251.71105092
22Gastric acid secretion_Homo sapiens_hsa049711.61450863
23Cocaine addiction_Homo sapiens_hsa050301.60170887
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.58337869
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.45453074
26Renin secretion_Homo sapiens_hsa049241.38588331
27Oxytocin signaling pathway_Homo sapiens_hsa049211.36258361
28Bile secretion_Homo sapiens_hsa049761.35864056
29* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34737108
30Calcium signaling pathway_Homo sapiens_hsa040201.31249499
31Taste transduction_Homo sapiens_hsa047421.24957067
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.23639262
33Type II diabetes mellitus_Homo sapiens_hsa049301.21607946
34Long-term depression_Homo sapiens_hsa047301.20094332
35GnRH signaling pathway_Homo sapiens_hsa049121.19748554
36Butanoate metabolism_Homo sapiens_hsa006501.14931833
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11626504
38Serotonergic synapse_Homo sapiens_hsa047261.09676217
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04590426
40Gap junction_Homo sapiens_hsa045401.03530404
41Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03071864
42* cAMP signaling pathway_Homo sapiens_hsa040241.03037942
43Phosphatidylinositol signaling system_Homo sapiens_hsa040700.99589344
44Glioma_Homo sapiens_hsa052140.93240992
45Estrogen signaling pathway_Homo sapiens_hsa049150.88350917
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81910754
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79519746
48Phototransduction_Homo sapiens_hsa047440.77382505
49Histidine metabolism_Homo sapiens_hsa003400.76926562
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.76415016
51Dorso-ventral axis formation_Homo sapiens_hsa043200.76008160
52Thyroid hormone synthesis_Homo sapiens_hsa049180.74882329
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73323347
54Melanogenesis_Homo sapiens_hsa049160.72769637
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72675432
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72465911
57ErbB signaling pathway_Homo sapiens_hsa040120.71917784
58Pancreatic secretion_Homo sapiens_hsa049720.71348755
59Glucagon signaling pathway_Homo sapiens_hsa049220.67595767
60Prion diseases_Homo sapiens_hsa050200.66413111
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64280610
62* Phospholipase D signaling pathway_Homo sapiens_hsa040720.61845581
63Collecting duct acid secretion_Homo sapiens_hsa049660.61614687
64Complement and coagulation cascades_Homo sapiens_hsa046100.60759975
65Tryptophan metabolism_Homo sapiens_hsa003800.60068919
66Arginine and proline metabolism_Homo sapiens_hsa003300.60021715
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59507286
68Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.56931883
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53045185
70PPAR signaling pathway_Homo sapiens_hsa033200.52858383
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52455170
72Axon guidance_Homo sapiens_hsa043600.51724293
73Choline metabolism in cancer_Homo sapiens_hsa052310.50964898
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50152740
75Type I diabetes mellitus_Homo sapiens_hsa049400.48191470
76Fatty acid degradation_Homo sapiens_hsa000710.45565417
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.45480566
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44870518
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44507685
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43899170
81Mineral absorption_Homo sapiens_hsa049780.43561519
82Dilated cardiomyopathy_Homo sapiens_hsa054140.42957741
83Cardiac muscle contraction_Homo sapiens_hsa042600.42376474
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41283708
85MAPK signaling pathway_Homo sapiens_hsa040100.41046705
86ABC transporters_Homo sapiens_hsa020100.41036992
87VEGF signaling pathway_Homo sapiens_hsa043700.40862624
88Oocyte meiosis_Homo sapiens_hsa041140.40825702
89Ovarian steroidogenesis_Homo sapiens_hsa049130.40533292
90Circadian rhythm_Homo sapiens_hsa047100.39924558
91Inositol phosphate metabolism_Homo sapiens_hsa005620.39714930
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37900262
93Non-small cell lung cancer_Homo sapiens_hsa052230.37732067
94mTOR signaling pathway_Homo sapiens_hsa041500.37533838
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.37156076
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.36017344
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35828078
98* Rap1 signaling pathway_Homo sapiens_hsa040150.35770151
99Insulin signaling pathway_Homo sapiens_hsa049100.35658963
100Fatty acid metabolism_Homo sapiens_hsa012120.35141320
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.35083604
102Alcoholism_Homo sapiens_hsa050340.34880496
103Fatty acid biosynthesis_Homo sapiens_hsa000610.34854137
104beta-Alanine metabolism_Homo sapiens_hsa004100.34844508
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.34493351
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33876254
107Vibrio cholerae infection_Homo sapiens_hsa051100.33457364
108Ras signaling pathway_Homo sapiens_hsa040140.33001393
109Glycerolipid metabolism_Homo sapiens_hsa005610.31998271
110Endocytosis_Homo sapiens_hsa041440.31098247
111Wnt signaling pathway_Homo sapiens_hsa043100.29856148
112Alzheimers disease_Homo sapiens_hsa050100.28838199
113Tight junction_Homo sapiens_hsa045300.22758004
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21641590
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21196214
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.19631618
117Hippo signaling pathway_Homo sapiens_hsa043900.18721124
118AMPK signaling pathway_Homo sapiens_hsa041520.17084032

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