RAP2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the Ras-related protein subfamily of the Ras GTPase superfamily. Members of this family are small GTPases that act as molecular switches to regulate cellular proliferation, differentiation, and apoptosis. This protein has been reported to activate in vitro transcriptional activity of the serum response element. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)5.27878831
2proteasome assembly (GO:0043248)5.02544107
3keratinocyte development (GO:0003334)4.04571730
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.98454894
5positive regulation by symbiont of host defense response (GO:0052509)3.88397590
6modulation by symbiont of host defense response (GO:0052031)3.88397590
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88397590
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88397590
9positive regulation by organism of defense response of other organism involved in symbiotic interact3.88397590
10modulation by symbiont of host immune response (GO:0052553)3.88397590
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.85013717
12histone exchange (GO:0043486)3.82089144
13mitotic sister chromatid cohesion (GO:0007064)3.76453405
14chromatin remodeling at centromere (GO:0031055)3.73646799
15positive regulation of glycoprotein biosynthetic process (GO:0010560)3.73440045
16somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.72068223
17somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.72068223
18isotype switching (GO:0045190)3.72068223
19CENP-A containing nucleosome assembly (GO:0034080)3.71382266
20leukocyte aggregation (GO:0070486)3.69801863
21RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.64849621
22DNA replication-dependent nucleosome assembly (GO:0006335)3.60161718
23DNA replication-dependent nucleosome organization (GO:0034723)3.60161718
24positive regulation of interferon-alpha production (GO:0032727)3.55598411
25regulation of interferon-alpha production (GO:0032647)3.45321735
26hepatocyte apoptotic process (GO:0097284)3.44641842
27positive regulation of glycoprotein metabolic process (GO:1903020)3.43983822
28replication fork processing (GO:0031297)3.42477023
29somite rostral/caudal axis specification (GO:0032525)3.40715500
30phospholipid scrambling (GO:0017121)3.35766972
31ribosome assembly (GO:0042255)3.33830865
32regulation of mesoderm development (GO:2000380)3.31341948
33lactate metabolic process (GO:0006089)3.28639078
34cellular extravasation (GO:0045123)3.27144987
35DNA deamination (GO:0045006)3.23536271
36regulation of interferon-beta biosynthetic process (GO:0045357)3.18505040
37regulation of centriole replication (GO:0046599)3.15426698
38histamine secretion (GO:0001821)3.12459561
39platelet dense granule organization (GO:0060155)3.11880736
40mitotic G2/M transition checkpoint (GO:0044818)3.11616421
41Arp2/3 complex-mediated actin nucleation (GO:0034314)3.10241149
42anterior/posterior axis specification, embryo (GO:0008595)3.09751852
43neutrophil activation involved in immune response (GO:0002283)3.07451261
44histone mRNA catabolic process (GO:0071044)3.07439645
45UDP-N-acetylglucosamine metabolic process (GO:0006047)3.05950600
46intestinal epithelial cell development (GO:0060576)3.05423465
47response to X-ray (GO:0010165)3.03869236
48respiratory burst (GO:0045730)3.03407531
49negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02871558
50negative regulation of cell killing (GO:0031342)3.02871558
51regulation of Rac protein signal transduction (GO:0035020)3.02717473
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99926465
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98082871
54DNA catabolic process, exonucleolytic (GO:0000738)2.97307817
55female gonad development (GO:0008585)2.97186692
56regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.97003347
57regulation of helicase activity (GO:0051095)2.95263785
58mitotic G2 DNA damage checkpoint (GO:0007095)2.92312398
59endoderm formation (GO:0001706)2.92070589
60nodal signaling pathway (GO:0038092)2.91731121
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90164231
62positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88866136
63dorsal/ventral axis specification (GO:0009950)2.87538529
64zinc ion transport (GO:0006829)2.86734322
65genitalia morphogenesis (GO:0035112)2.86321302
66positive regulation of chemokine biosynthetic process (GO:0045080)2.86320961
67regulation of interleukin-12 biosynthetic process (GO:0045075)2.85267312
68DNA replication-independent nucleosome organization (GO:0034724)2.84223735
69DNA replication-independent nucleosome assembly (GO:0006336)2.84223735
70DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.83395134
71anterior/posterior axis specification (GO:0009948)2.83338141
72non-recombinational repair (GO:0000726)2.82699143
73double-strand break repair via nonhomologous end joining (GO:0006303)2.82699143
74negative regulation of axon extension involved in axon guidance (GO:0048843)2.81833189
75regulation of mitotic spindle checkpoint (GO:1903504)2.80616525
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.80616525
77cell adhesion mediated by integrin (GO:0033627)2.79994575
78signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.79454567
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.79454567
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.79454567
81cellular response to interferon-alpha (GO:0035457)2.78723885
82embryonic foregut morphogenesis (GO:0048617)2.78208018
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.77425240
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.77425240
85T cell migration (GO:0072678)2.77264206
86macrophage activation involved in immune response (GO:0002281)2.76251632
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75927144
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75927144
89exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71740745
90regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.71738391
91regulation of sulfur metabolic process (GO:0042762)2.70460548
92positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.68912234
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.66622187
94regulation of B cell receptor signaling pathway (GO:0050855)2.66311080
95response to peptidoglycan (GO:0032494)2.63969025
96protein neddylation (GO:0045116)2.63895611
97positive regulation of gamma-delta T cell activation (GO:0046645)2.63564652
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.63375382
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63375382
100N-terminal protein amino acid acetylation (GO:0006474)2.63128028
101negative regulation of thymocyte apoptotic process (GO:0070244)2.62969681
102histone mRNA metabolic process (GO:0008334)2.62081783
103metaphase plate congression (GO:0051310)2.61885705
104regulation of cellular amino acid metabolic process (GO:0006521)2.61841880
105maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.61680699
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.61140209
107gastrulation (GO:0007369)2.60579086
108homocysteine metabolic process (GO:0050667)2.59244061
109negative regulation of activin receptor signaling pathway (GO:0032926)2.58534327
110cullin deneddylation (GO:0010388)2.58354252
111response to host immune response (GO:0052572)2.57909459
112response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57909459
113negative regulation of heart growth (GO:0061117)2.57524996
114negative regulation of cardiac muscle tissue growth (GO:0055022)2.57524996
115regulation of cytokine secretion involved in immune response (GO:0002739)2.56859318
116granulocyte activation (GO:0036230)2.56543678
117antigen processing and presentation of endogenous antigen (GO:0019883)2.56314032
118pinocytosis (GO:0006907)2.55642627
119negative regulation of DNA recombination (GO:0045910)2.55522719
120positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.54943043
121positive regulation of lamellipodium assembly (GO:0010592)2.54383307
122spindle checkpoint (GO:0031577)2.53377138
123neutrophil activation (GO:0042119)2.53288975
124mitotic metaphase plate congression (GO:0007080)2.52982528
125negative regulation of mRNA metabolic process (GO:1903312)2.52815292
126negative regulation of ligase activity (GO:0051352)2.52783361
127negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.52783361
128production of molecular mediator involved in inflammatory response (GO:0002532)2.52745428
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.52661271
130anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52336908
131nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.52239599
132response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.52134420
133response to host (GO:0075136)2.52134420
134response to host defenses (GO:0052200)2.52134420
135synapsis (GO:0007129)2.51463479
136branched-chain amino acid catabolic process (GO:0009083)2.50307603
137regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.49977413
138primitive streak formation (GO:0090009)2.49181147
139purine nucleobase biosynthetic process (GO:0009113)2.48578212
140embryonic axis specification (GO:0000578)2.48552825
141substrate-dependent cell migration (GO:0006929)2.47499629
142mitotic spindle checkpoint (GO:0071174)2.47285745
143I-kappaB phosphorylation (GO:0007252)2.45727159
144immunoglobulin mediated immune response (GO:0016064)2.44156910
145positive regulation of interferon-beta production (GO:0032728)2.44005310
146response to interferon-alpha (GO:0035455)2.43886390
147positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.42792384
148response to type I interferon (GO:0034340)2.42509044
149leukocyte cell-cell adhesion (GO:0007159)2.42229413
150regulation of alpha-beta T cell proliferation (GO:0046640)2.42046964
151growth hormone receptor signaling pathway (GO:0060396)2.40182571
152cellular response to type I interferon (GO:0071357)2.39639877
153type I interferon signaling pathway (GO:0060337)2.39639877
154positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.39164533
155endodermal cell differentiation (GO:0035987)2.37253911
156complement activation, alternative pathway (GO:0006957)2.36196873
157triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.36166447
158cytokine secretion (GO:0050663)2.34833121
159regulation of T cell chemotaxis (GO:0010819)2.34285545
160positive regulation of T cell chemotaxis (GO:0010820)2.34285545
161actin nucleation (GO:0045010)2.34202731
162positive regulation of macrophage differentiation (GO:0045651)2.33832343
163hippo signaling (GO:0035329)2.33162332
164negative regulation of B cell proliferation (GO:0030889)2.32254625
165cytoplasmic mRNA processing body assembly (GO:0033962)2.28021747
166fibrinolysis (GO:0042730)2.27972344
167interferon-gamma-mediated signaling pathway (GO:0060333)2.27963814
168positive regulation of toll-like receptor signaling pathway (GO:0034123)2.27679677
169peptidyl-glutamic acid carboxylation (GO:0017187)2.26747631
170protein carboxylation (GO:0018214)2.26747631
171hydrogen peroxide biosynthetic process (GO:0050665)2.24598900
172negative thymic T cell selection (GO:0045060)2.23997429
173positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.23624229
174establishment of endothelial barrier (GO:0061028)2.22435797
175negative T cell selection (GO:0043383)2.22091000
176positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.20440578
177positive regulation of cytokine biosynthetic process (GO:0042108)2.20214775
178regulation of heterotypic cell-cell adhesion (GO:0034114)2.17761691
179B cell mediated immunity (GO:0019724)2.16779263
180regulation of hypersensitivity (GO:0002883)2.15781663
181regulation of B cell differentiation (GO:0045577)2.14776228
182regulation of gamma-delta T cell differentiation (GO:0045586)2.14737533
183regulation of lymphocyte migration (GO:2000401)2.14718724
184positive regulation of alpha-beta T cell proliferation (GO:0046641)2.14424060
185regulation of T cell tolerance induction (GO:0002664)2.14012610
186lipopolysaccharide-mediated signaling pathway (GO:0031663)2.13203053
187skin morphogenesis (GO:0043589)2.12961282
188JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.12417676
189alpha-linolenic acid metabolic process (GO:0036109)2.11696784
190positive regulation of natural killer cell differentiation (GO:0032825)2.11443074
191protein localization to endosome (GO:0036010)2.10980030
192positive regulation of hemostasis (GO:1900048)2.10598141
193positive regulation of blood coagulation (GO:0030194)2.10598141
194regulation of mononuclear cell migration (GO:0071675)2.09793032
195integrin-mediated signaling pathway (GO:0007229)2.09406488
196heterotypic cell-cell adhesion (GO:0034113)2.08655350

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.54214169
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.33807865
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.19339335
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.83178373
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.78760597
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.47140648
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.19302421
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.09674193
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.09615033
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.02694926
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94925425
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.92953662
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89718298
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.86141509
15ELK1_19687146_ChIP-ChIP_HELA_Human2.68128636
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64163810
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.60130903
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58441259
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.48748542
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.43709966
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41353287
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.41216537
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.40348157
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.38888000
25ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.28133308
26* GABP_17652178_ChIP-ChIP_JURKAT_Human2.26327297
27EWS_26573619_Chip-Seq_HEK293_Human2.19862613
28EST1_17652178_ChIP-ChIP_JURKAT_Human2.10064677
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98748944
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.97454575
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94069481
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92648247
33CLOCK_20551151_ChIP-Seq_293T_Human1.90514316
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90428114
35RUNX_20019798_ChIP-Seq_JUKART_Human1.89513796
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88604346
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85278342
38* P300_19829295_ChIP-Seq_ESCs_Human1.82555340
39* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.82081034
40VDR_22108803_ChIP-Seq_LS180_Human1.81770482
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.81025879
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80177255
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.79957781
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79474232
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78589527
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.75759564
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71887793
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.71812781
49MAF_26560356_Chip-Seq_TH1_Human1.69853132
50CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68834543
51MYB_26560356_Chip-Seq_TH2_Human1.68660523
52E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66759642
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.66359387
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63136338
55ZNF274_21170338_ChIP-Seq_K562_Hela1.61889226
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.60892014
57VDR_24787735_ChIP-Seq_THP-1_Human1.59550570
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.59387491
59VDR_23849224_ChIP-Seq_CD4+_Human1.59213927
60PU_27001747_Chip-Seq_BMDM_Mouse1.58082913
61FUS_26573619_Chip-Seq_HEK293_Human1.57258311
62AR_21909140_ChIP-Seq_LNCAP_Human1.53631648
63TAF15_26573619_Chip-Seq_HEK293_Human1.52727551
64MYB_26560356_Chip-Seq_TH1_Human1.50078455
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49344239
66NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.49275311
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45520973
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45363594
69* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44819193
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44583169
71FOXO3_23340844_ChIP-Seq_DLD1_Human1.43718984
72STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.42600635
73ER_23166858_ChIP-Seq_MCF-7_Human1.42583068
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42329744
75* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.40872985
76VDR_24763502_ChIP-Seq_THP-1_Human1.40207968
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40080513
78SPI1_23547873_ChIP-Seq_NB4_Human1.39256955
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38920283
80CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38456460
81* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38422092
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36909527
83FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36823619
84SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36635864
85SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36635864
86SALL4_18804426_ChIP-ChIP_XEN_Mouse1.36585103
87TCF7_22412390_ChIP-Seq_EML_Mouse1.35284014
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.35151202
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.33016690
90RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.32930274
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31443066
92SCL_19346495_ChIP-Seq_HPC-7_Human1.30769320
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30701483
94CJUN_26792858_Chip-Seq_BT549_Human1.30555345
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29437689
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28881350
97UTX_26944678_Chip-Seq_JUKART_Human1.28420813
98GATA1_22025678_ChIP-Seq_K562_Human1.28152731
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.28139013
100FOXP3_21729870_ChIP-Seq_TREG_Human1.27303971
101SMAD3_21741376_ChIP-Seq_EPCs_Human1.24988375
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.24974181
103FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24024319
104PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.24017736
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23604855
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23081250
107NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23081250
108BRD4_25478319_ChIP-Seq_HGPS_Human1.21457853
109BCAT_22108803_ChIP-Seq_LS180_Human1.18402987
110CDX2_22108803_ChIP-Seq_LS180_Human1.17971486
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16866155
112RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16700602
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16638343
114FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16612097
115HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.16608311
116KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15884734
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.14354908
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13358046
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13238610
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12154458
121SOX2_19829295_ChIP-Seq_ESCs_Human1.12095060
122NANOG_19829295_ChIP-Seq_ESCs_Human1.12095060
123SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12064174
124MYC_22102868_ChIP-Seq_BL_Human1.12001383
125E2F7_22180533_ChIP-Seq_HELA_Human1.11537718
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10766269
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.10306506
128PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09938939
129VDR_21846776_ChIP-Seq_THP-1_Human1.09797346
130SOX2_20726797_ChIP-Seq_SW620_Human1.09745652
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09711026
132SALL4_22934838_ChIP-ChIP_CD34+_Human1.08665470
133MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07519043
134MYC_18940864_ChIP-ChIP_HL60_Human1.07286375
135SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07131718
136PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06752208
137OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06540259
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06367588
139SPI1_23127762_ChIP-Seq_K562_Human1.05796895
140GATA2_21666600_ChIP-Seq_HMVEC_Human1.05719916
141CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05143849
142KDM2B_26808549_Chip-Seq_DND41_Human1.04801086
143RUNX1_22412390_ChIP-Seq_EML_Mouse1.04656678
144NANOG_18555785_Chip-Seq_ESCs_Mouse1.04389604
145KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.03707066
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.03707066
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.03707066
148* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03566585
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03427624
150PIAS1_25552417_ChIP-Seq_VCAP_Human1.02856790
151MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02562288
152ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02187671
153CMYC_18555785_Chip-Seq_ESCs_Mouse1.01649549
154GATA3_27048872_Chip-Seq_THYMUS_Human1.01633104
155KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01355594
156KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01047541
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01015152
158EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00671998
159SMAD4_21741376_ChIP-Seq_EPCs_Human0.99983726
160P300_18555785_Chip-Seq_ESCs_Mouse0.99926136
161SMAD3_21741376_ChIP-Seq_HESCs_Human0.99648814
162PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99488721
163TCF4_22108803_ChIP-Seq_LS180_Human0.98968581
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97585042
165ELF5_23300383_ChIP-Seq_T47D_Human0.96524044
166EGR1_19032775_ChIP-ChIP_M12_Human0.96498689
167ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95945231
168ESR1_20079471_ChIP-ChIP_T-47D_Human0.95836334
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95546555
170P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95379782
171FOXM1_23109430_ChIP-Seq_U2OS_Human0.93860377
172SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93422214
173KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93303567
174TP53_16413492_ChIP-PET_HCT116_Human0.93256630
175SALL1_21062744_ChIP-ChIP_HESCs_Human0.92817606
176GATA3_26560356_Chip-Seq_TH2_Human0.91077942
177UBF1/2_26484160_Chip-Seq_HMECs_Human0.90335209
178TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88694722

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.62977259
2MP0003890_abnormal_embryonic-extraembry3.85747994
3MP0003195_calcinosis3.59252449
4MP0008057_abnormal_DNA_replication3.22211835
5MP0008438_abnormal_cutaneous_collagen3.14580514
6MP0003436_decreased_susceptibility_to2.89984694
7MP0010352_gastrointestinal_tract_polyps2.70256349
8MP0003941_abnormal_skin_development2.68693597
9MP0003303_peritoneal_inflammation2.64084102
10MP0001835_abnormal_antigen_presentation2.54129742
11MP0003300_gastrointestinal_ulcer2.52978945
12MP0010094_abnormal_chromosome_stability2.46758748
13MP0003705_abnormal_hypodermis_morpholog2.38071389
14MP0009785_altered_susceptibility_to2.29192358
15MP0006054_spinal_hemorrhage2.24891915
16MP0002102_abnormal_ear_morphology2.11196762
17MP0004957_abnormal_blastocyst_morpholog2.08066941
18MP0002166_altered_tumor_susceptibility2.07589147
19MP0005387_immune_system_phenotype2.03921689
20MP0001790_abnormal_immune_system2.03921689
21MP0006082_CNS_inflammation2.00853246
22MP0005275_abnormal_skin_tensile1.98910338
23MP0005000_abnormal_immune_tolerance1.96038426
24MP0005367_renal/urinary_system_phenotyp1.95238483
25MP0000516_abnormal_urinary_system1.95238483
26MP0000685_abnormal_immune_system1.91475240
27MP0008004_abnormal_stomach_pH1.91090950
28MP0002419_abnormal_innate_immunity1.87817897
29MP0002139_abnormal_hepatobiliary_system1.87448178
30MP0003724_increased_susceptibility_to1.87428698
31MP0009697_abnormal_copulation1.86967963
32MP0008877_abnormal_DNA_methylation1.86558226
33MP0008058_abnormal_DNA_repair1.86412803
34MP0002148_abnormal_hypersensitivity_rea1.85584731
35MP0009053_abnormal_anal_canal1.83818022
36MP0003786_premature_aging1.83330653
37MP0001800_abnormal_humoral_immune1.82892626
38MP0001533_abnormal_skeleton_physiology1.81920740
39MP0005025_abnormal_response_to1.78444499
40MP0002006_tumorigenesis1.76273370
41MP0002452_abnormal_antigen_presenting1.75949115
42MP0008007_abnormal_cellular_replicative1.74811860
43MP0005503_abnormal_tendon_morphology1.65784953
44MP0005076_abnormal_cell_differentiation1.65154076
45MP0005360_urolithiasis1.64863312
46MP0005671_abnormal_response_to1.64522958
47MP0004510_myositis1.63401802
48MP0000372_irregular_coat_pigmentation1.60361897
49MP0002723_abnormal_immune_serum1.57410660
50MP0010307_abnormal_tumor_latency1.57326573
51MP0003566_abnormal_cell_adhesion1.56871543
52MP0004947_skin_inflammation1.56194620
53MP0003448_altered_tumor_morphology1.55901959
54MP0002138_abnormal_hepatobiliary_system1.53232821
55MP0000427_abnormal_hair_cycle1.49156066
56MP0010234_abnormal_vibrissa_follicle1.46495515
57MP0001819_abnormal_immune_cell1.46069788
58MP0005075_abnormal_melanosome_morpholog1.45398316
59MP0002420_abnormal_adaptive_immunity1.44514031
60MP0003252_abnormal_bile_duct1.44068229
61MP0005023_abnormal_wound_healing1.43986912
62MP0003806_abnormal_nucleotide_metabolis1.42764063
63MP0005464_abnormal_platelet_physiology1.41656593
64MP0002933_joint_inflammation1.40357503
65MP0008995_early_reproductive_senescence1.36858720
66MP0009278_abnormal_bone_marrow1.36694333
67MP0010155_abnormal_intestine_physiology1.36293942
68MP0004264_abnormal_extraembryonic_tissu1.35897277
69MP0000343_altered_response_to1.31931548
70MP0003693_abnormal_embryo_hatching1.31486496
71MP0003453_abnormal_keratinocyte_physiol1.28189836
72MP0004272_abnormal_basement_membrane1.27941414
73MP0002405_respiratory_system_inflammati1.27109248
74MP0002751_abnormal_autonomic_nervous1.26622112
75MP0002277_abnormal_respiratory_mucosa1.25884627
76MP0009764_decreased_sensitivity_to1.25669633
77MP0001845_abnormal_inflammatory_respons1.24128334
78MP0004808_abnormal_hematopoietic_stem1.23167186
79MP0003943_abnormal_hepatobiliary_system1.23060128
80MP0000733_abnormal_muscle_development1.20540623
81MP0009333_abnormal_splenocyte_physiolog1.17622012
82MP0003111_abnormal_nucleus_morphology1.17026134
83MP0000858_altered_metastatic_potential1.16486434
84MP0001545_abnormal_hematopoietic_system1.13809287
85MP0005397_hematopoietic_system_phenotyp1.13809287
86MP0004484_altered_response_of1.13300988
87MP0005390_skeleton_phenotype1.13041920
88MP0002398_abnormal_bone_marrow1.13018315
89MP0000716_abnormal_immune_system1.12180605
90MP0002009_preneoplasia1.11863898
91MP0003279_aneurysm1.11267319
92MP0000569_abnormal_digit_pigmentation1.11000595
93MP0008932_abnormal_embryonic_tissue1.09739571
94MP0004215_abnormal_myocardial_fiber1.09710913
95MP0009384_cardiac_valve_regurgitation1.09110126
96MP0010368_abnormal_lymphatic_system1.07626818
97MP0003091_abnormal_cell_migration1.07274685
98MP0002998_abnormal_bone_remodeling1.07079653
99MP0005085_abnormal_gallbladder_physiolo1.06178779
100MP0009840_abnormal_foam_cell1.05669804
101MP0001853_heart_inflammation1.05611075
102MP0008469_abnormal_protein_level1.03726187
103MP0003119_abnormal_digestive_system1.03651711
104MP0003077_abnormal_cell_cycle1.03001852
105MP0003191_abnormal_cellular_cholesterol1.02486063
106MP0000767_abnormal_smooth_muscle1.02386079
107MP0001666_abnormal_nutrient_absorption1.01201886
108MP0003828_pulmonary_edema1.01160841
109MP0005248_abnormal_Harderian_gland0.96539529
110MP0001243_abnormal_dermal_layer0.94831484
111MP0000689_abnormal_spleen_morphology0.93233530
112MP0002837_dystrophic_cardiac_calcinosis0.92312410
113MP0002722_abnormal_immune_system0.91847021
114MP0005380_embryogenesis_phenotype0.90557519
115MP0001672_abnormal_embryogenesis/_devel0.90557519
116MP0000465_gastrointestinal_hemorrhage0.89561186
117MP0001915_intracranial_hemorrhage0.89506934
118MP0002429_abnormal_blood_cell0.89472059
119MP0001727_abnormal_embryo_implantation0.89022387
120MP0001851_eye_inflammation0.88492860
121MP0002060_abnormal_skin_morphology0.88467619
122MP0000249_abnormal_blood_vessel0.88055837
123MP0002090_abnormal_vision0.87915174
124MP0005164_abnormal_response_to0.87814932
125MP0001697_abnormal_embryo_size0.86866754
126MP0000377_abnormal_hair_follicle0.86612598
127MP0003763_abnormal_thymus_physiology0.85997616
128MP0005084_abnormal_gallbladder_morpholo0.85748582
129MP0003221_abnormal_cardiomyocyte_apopto0.85704755
130MP0004185_abnormal_adipocyte_glucose0.85219414
131MP0002396_abnormal_hematopoietic_system0.84826427
132MP0002088_abnormal_embryonic_growth/wei0.84315386
133MP0001873_stomach_inflammation0.84293669
134MP0003186_abnormal_redox_activity0.84090866
135MP0003937_abnormal_limbs/digits/tail_de0.83915533
136MP0001879_abnormal_lymphatic_vessel0.82781375
137MP0000609_abnormal_liver_physiology0.82495156
138MP0001119_abnormal_female_reproductive0.80695586
139MP0010678_abnormal_skin_adnexa0.80203689
140MP0009763_increased_sensitivity_to0.80118393
141MP0001216_abnormal_epidermal_layer0.79014671
142MP0006035_abnormal_mitochondrial_morpho0.78859546
143MP0001485_abnormal_pinna_reflex0.78850103
144MP0003656_abnormal_erythrocyte_physiolo0.78703640
145MP0003567_abnormal_fetal_cardiomyocyte0.77970247
146MP0002168_other_aberrant_phenotype0.77757992
147MP0006036_abnormal_mitochondrial_physio0.77200059
148MP0005365_abnormal_bile_salt0.76720749
149MP0002282_abnormal_trachea_morphology0.76574627
150MP0003984_embryonic_growth_retardation0.76233912
151MP0005058_abnormal_lysosome_morphology0.76000312
152MP0000647_abnormal_sebaceous_gland0.75352550
153MP0000604_amyloidosis0.74701932
154MP0004883_abnormal_blood_vessel0.73797847
155MP0002128_abnormal_blood_circulation0.73236692
156MP0005647_abnormal_sex_gland0.71387635
157MP0001730_embryonic_growth_arrest0.70181265
158MP0000383_abnormal_hair_follicle0.69011848
159MP0002084_abnormal_developmental_patter0.68563081
160MP0005395_other_phenotype0.68219356
161MP0000358_abnormal_cell_content/0.66973718
162MP0005220_abnormal_exocrine_pancreas0.65603366
163MP0000538_abnormal_urinary_bladder0.64851696
164MP0001177_atelectasis0.64824923
165MP0005310_abnormal_salivary_gland0.62808262
166MP0008872_abnormal_physiological_respon0.62785004
167MP0002086_abnormal_extraembryonic_tissu0.62725057
168MP0002127_abnormal_cardiovascular_syste0.61839259
169MP0001293_anophthalmia0.61163549
170MP0001984_abnormal_olfaction0.60401475
171MP0002132_abnormal_respiratory_system0.59994426
172MP0000350_abnormal_cell_proliferation0.59823720

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.32459496
2Recurrent abscess formation (HP:0002722)3.82459508
3Recurrent bacterial skin infections (HP:0005406)3.81423534
4Recurrent gram-negative bacterial infections (HP:0005420)3.66826432
5Abnormality of chromosome stability (HP:0003220)3.36701320
6Systemic lupus erythematosus (HP:0002725)3.30042423
7Rhabdomyosarcoma (HP:0002859)3.19813166
8Protrusio acetabuli (HP:0003179)3.17647778
9Abnormality of methionine metabolism (HP:0010901)3.13972394
10Autoimmune thrombocytopenia (HP:0001973)3.13713269
11Thyroiditis (HP:0100646)3.09707967
12B lymphocytopenia (HP:0010976)3.09688898
13Abnormal umbilical cord blood vessels (HP:0011403)3.06923591
14Single umbilical artery (HP:0001195)3.06923591
15Abnormality of the fetal cardiovascular system (HP:0010948)3.06923591
16Abnormality of B cell number (HP:0010975)3.06125467
17Methylmalonic acidemia (HP:0002912)3.01379110
18Pancreatic islet-cell hyperplasia (HP:0004510)3.00187913
19Myocardial infarction (HP:0001658)3.00135110
20Breast carcinoma (HP:0003002)2.97264255
21Osteolytic defects of the phalanges of the hand (HP:0009771)2.94841967
22Osteolytic defects of the hand bones (HP:0009699)2.94841967
23Volvulus (HP:0002580)2.92134371
24Hematochezia (HP:0002573)2.81318161
25Progressive inability to walk (HP:0002505)2.80439909
26Spontaneous hematomas (HP:0007420)2.78657420
27Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78148624
28Disinhibition (HP:0000734)2.73831183
29Complement deficiency (HP:0004431)2.68250534
30Peritonitis (HP:0002586)2.67641505
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.67480024
32Glomerulonephritis (HP:0000099)2.67041438
33Abnormality of the parathyroid morphology (HP:0011766)2.62834776
34Intestinal atresia (HP:0011100)2.62680149
35Thick nail (HP:0001805)2.62203300
36Axonal loss (HP:0003447)2.61139907
37Ependymoma (HP:0002888)2.58855538
38Premature rupture of membranes (HP:0001788)2.58296674
39Chromsome breakage (HP:0040012)2.56731008
40Curly hair (HP:0002212)2.53620518
41Glioma (HP:0009733)2.52209234
42Abnormal lung lobation (HP:0002101)2.51256313
43Neoplasm of the adrenal gland (HP:0100631)2.49969903
44Congenital malformation of the right heart (HP:0011723)2.48976216
45Double outlet right ventricle (HP:0001719)2.48976216
46Syringomyelia (HP:0003396)2.48670767
47Spinal cord lesions (HP:0100561)2.48670767
48Papilledema (HP:0001085)2.48535705
49Aqueductal stenosis (HP:0002410)2.48104029
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.48036246
51Stomatitis (HP:0010280)2.46701608
52Deep venous thrombosis (HP:0002625)2.44008633
53Recurrent viral infections (HP:0004429)2.43787247
54Abnormality of the umbilical cord (HP:0010881)2.43283534
55Meckel diverticulum (HP:0002245)2.42556101
56Subacute progressive viral hepatitis (HP:0006572)2.42513250
57Abnormality of vitamin B metabolism (HP:0004340)2.41150634
58Gonadotropin excess (HP:0000837)2.37784196
59Hypothermia (HP:0002045)2.34853964
60Mediastinal lymphadenopathy (HP:0100721)2.34712641
61Aortic dissection (HP:0002647)2.31252062
62Abnormality of macrophages (HP:0004311)2.31136278
63Abnormality of the astrocytes (HP:0100707)2.30012661
64Astrocytoma (HP:0009592)2.30012661
65Hypoproteinemia (HP:0003075)2.29962656
66Ankle contracture (HP:0006466)2.29921233
67Abnormality of the ileum (HP:0001549)2.29798215
68Hypoplastic pelvis (HP:0008839)2.29427181
69Gastrointestinal infarctions (HP:0005244)2.28280318
70Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27758608
71Short 4th metacarpal (HP:0010044)2.27758608
72Elevated erythrocyte sedimentation rate (HP:0003565)2.27610269
73Myositis (HP:0100614)2.27484556
74Abnormality of the preputium (HP:0100587)2.27471200
75Recurrent skin infections (HP:0001581)2.27353824
76Recurrent fungal infections (HP:0002841)2.26975463
77Abnormality of T cell number (HP:0011839)2.25157528
78Gingival bleeding (HP:0000225)2.22563189
79Cellulitis (HP:0100658)2.22526869
80Meningioma (HP:0002858)2.21791919
81Vertebral compression fractures (HP:0002953)2.19809123
82Embryonal renal neoplasm (HP:0011794)2.19764856
83Spondylolisthesis (HP:0003302)2.19544346
84Abnormality of complement system (HP:0005339)2.18956663
85Severe combined immunodeficiency (HP:0004430)2.18708617
86Asymmetry of the thorax (HP:0001555)2.18185515
87Ovarian neoplasm (HP:0100615)2.18178253
88Facial diplegia (HP:0001349)2.17986459
89Abnormality of the common coagulation pathway (HP:0010990)2.17832062
90Symptomatic seizures (HP:0011145)2.17268359
91Abnormality of the vitamin B12 metabolism (HP:0004341)2.17211428
92Combined immunodeficiency (HP:0005387)2.16496671
93Increased density of long bones (HP:0006392)2.15146185
94Mitral valve prolapse (HP:0001634)2.15061117
95T lymphocytopenia (HP:0005403)2.15020694
96Hamartoma of the eye (HP:0010568)2.12894407
97Increased cerebral lipofuscin (HP:0011813)2.12587497
98Disproportionate short-trunk short stature (HP:0003521)2.12266105
99Obstructive lung disease (HP:0006536)2.10423633
100Chronic obstructive pulmonary disease (HP:0006510)2.10423633
101Gingivitis (HP:0000230)2.10380524
102Short middle phalanx of the 5th finger (HP:0004220)2.09816166
103Shallow orbits (HP:0000586)2.09312446
104Abnormal pancreas size (HP:0012094)2.09241448
105Abnormal platelet volume (HP:0011876)2.08970817
106Nephroblastoma (Wilms tumor) (HP:0002667)2.08729935
107Increased mean platelet volume (HP:0011877)2.07790829
108Aortic aneurysm (HP:0004942)2.07639220
109Anal stenosis (HP:0002025)2.07039542
110Increased neuronal autofluorescent lipopigment (HP:0002074)2.05780536
111Abnormality of the lumbar spine (HP:0100712)2.05761789
112Urticaria (HP:0001025)2.05180856
113Nephritis (HP:0000123)2.04109571
114Mitral stenosis (HP:0001718)2.03306517
115Xanthomatosis (HP:0000991)2.02972979
116Abdominal situs inversus (HP:0003363)2.01902492
117Abnormality of abdominal situs (HP:0011620)2.01902492
118Esophageal varix (HP:0002040)2.01740366
119Vasculitis (HP:0002633)2.01228455
120Transitional cell carcinoma of the bladder (HP:0006740)2.01137141
121Abnormality of endocrine pancreas physiology (HP:0012093)2.00978069
122Abnormality of the pancreatic islet cells (HP:0006476)2.00978069
123Neoplasm of the adrenal cortex (HP:0100641)2.00613499
124Hypobetalipoproteinemia (HP:0003563)1.99491282
125Dyschromatopsia (HP:0007641)1.99336848
126Abnormality of the duodenum (HP:0002246)1.99199283
127Methylmalonic aciduria (HP:0012120)1.99082936
128Pustule (HP:0200039)1.98827199
129Hypoglycemic seizures (HP:0002173)1.98064394
130Gonadal dysgenesis (HP:0000133)1.96800429
131Osteomyelitis (HP:0002754)1.96057977
132Abnormal hair whorl (HP:0010721)1.95251685
133Colon cancer (HP:0003003)1.93922898
134Abnormalities of placenta or umbilical cord (HP:0001194)1.93335346
135Agnosia (HP:0010524)1.91592939
136Periodontitis (HP:0000704)1.91293903
137Arterial thrombosis (HP:0004420)1.91061279
138Abnormality of the 4th metacarpal (HP:0010012)1.89866897
139Bifid tongue (HP:0010297)1.89608514
140Posterior subcapsular cataract (HP:0007787)1.89577631
141Clubbing of toes (HP:0100760)1.89569760
142Bladder neoplasm (HP:0009725)1.89014426
143Bladder carcinoma (HP:0002862)1.89014426
144Dilatation of the ascending aorta (HP:0005111)1.89000672
145Conjunctival hamartoma (HP:0100780)1.87905984
146Intrahepatic cholestasis (HP:0001406)1.86538603
147Uterine neoplasm (HP:0010784)1.86109481
148Neoplasm of striated muscle (HP:0009728)1.83847935
149Delayed closure of the anterior fontanelle (HP:0001476)1.82856525
150Sensory axonal neuropathy (HP:0003390)1.82723561
151Duodenal stenosis (HP:0100867)1.82254412
152Small intestinal stenosis (HP:0012848)1.82254412
153Disproportionate tall stature (HP:0001519)1.82188545
154Hypolipoproteinemia (HP:0010981)1.82060193
155Cerebral aneurysm (HP:0004944)1.81788286
156Abnormality of homocysteine metabolism (HP:0010919)1.80761249
157Homocystinuria (HP:0002156)1.80761249
158Basal ganglia calcification (HP:0002135)1.79895836
159Broad metatarsal (HP:0001783)1.79701930
160Absent frontal sinuses (HP:0002688)1.79362061
161Abnormality of the distal phalanges of the toes (HP:0010182)1.79252667
162Cutaneous melanoma (HP:0012056)1.78566631
163Orchitis (HP:0100796)1.78237825
164Asplenia (HP:0001746)1.77412981
165Leukocytosis (HP:0001974)1.76860759
166Tongue fasciculations (HP:0001308)1.76687234
167Hemorrhage of the eye (HP:0011885)1.75544135
168Eosinophilia (HP:0001880)1.74448695
169Blue sclerae (HP:0000592)1.74386463
170Increased IgE level (HP:0003212)1.74215771
171Pulmonary embolism (HP:0002204)1.73409165
172Abnormality of monocarboxylic acid metabolism (HP:0010996)1.70918099
173Persistence of primary teeth (HP:0006335)1.70785174
174Interstitial pulmonary disease (HP:0006530)1.70189906
175Adenoma sebaceum (HP:0009720)1.69915582
176Angiofibromas (HP:0010615)1.69915582
177Biliary tract neoplasm (HP:0100574)1.68547734
178Multiple enchondromatosis (HP:0005701)1.67899381
179Abnormality of serum amino acid levels (HP:0003112)1.67148809
180Abolished electroretinogram (ERG) (HP:0000550)1.66924229
181Septo-optic dysplasia (HP:0100842)1.66727738
182Amyloidosis (HP:0011034)1.66492680
183Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66441625
184Aplasia/Hypoplasia of the spleen (HP:0010451)1.66194654
185Mucosal telangiectasiae (HP:0100579)1.65690714
186Cervical subluxation (HP:0003308)1.65176096
187Hypercholesterolemia (HP:0003124)1.64446806
188Rectal prolapse (HP:0002035)1.64195670
189Exercise-induced muscle cramps (HP:0003710)1.62777812
190Chronic otitis media (HP:0000389)1.62730288
191Frequent falls (HP:0002359)1.62673333
192Abnormality of the peritoneum (HP:0002585)1.62099153
193Narrow palate (HP:0000189)1.61338222
194Camptodactyly of toe (HP:0001836)1.60831048
195Arterial tortuosity (HP:0005116)1.60739240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM285.20096363
2SIK34.25169796
3EIF2AK33.75958389
4MKNK23.46352737
5BMPR1B2.61186668
6MAP3K142.54016242
7MAP3K102.46044450
8STK32.42718596
9TNIK2.40654089
10MAP4K12.40545240
11EIF2AK12.35914553
12WNK32.35883402
13MKNK12.30415014
14STK102.30108740
15NME22.24651845
16TYK22.22352401
17TXK2.10233901
18FGFR32.06016221
19TBK12.03003690
20CSF1R1.98074220
21NEK91.95406898
22EPHB11.91724167
23PKN21.91591742
24ERN11.85965225
25JAK11.84135607
26BCR1.82595341
27CDK61.81233750
28EPHA31.79680047
29FGFR41.78623651
30MAP4K21.77159031
31BUB11.77118241
32PLK31.74044315
33CSK1.72903530
34LRRK21.65175358
35IKBKE1.58016930
36TGFBR21.57031697
37JAK31.56794273
38IRAK41.54795257
39LATS11.52042496
40RPS6KA41.51325938
41BRSK21.49266033
42ITK1.45530672
43EPHB21.43281675
44BLK1.42071829
45ACVR1B1.41370755
46TRIB31.38090433
47HCK1.36923785
48ZAP701.36623806
49PLK41.35448975
50PIK3CG1.32192435
51MAP3K121.31803866
52PLK21.31057607
53TTN1.28776703
54CAMK1D1.27417852
55IKBKB1.26934843
56EEF2K1.23494220
57DMPK1.22788607
58PTK61.20569141
59TSSK61.19150870
60TAF11.14270358
61ERBB41.13784193
62STK38L1.13740417
63EIF2AK21.13256330
64STK391.11540547
65SIK11.10167622
66TTK1.07767996
67ERBB31.04017800
68TRPM71.02270871
69SRPK11.01537110
70CHUK1.00520778
71STK40.99696457
72LCK0.98672832
73GRK10.97426800
74MAP3K30.97249548
75FER0.95754861
76OXSR10.95011227
77BTK0.94964556
78KIT0.94099267
79PIM20.91286091
80CLK10.90170278
81MAP2K30.89818401
82TEC0.89519702
83TGFBR10.89448581
84FRK0.88486521
85MARK30.88156669
86PBK0.86643743
87SYK0.85829944
88NUAK10.85718556
89RIPK40.85401826
90CAMK1G0.84573629
91PIM10.83638770
92FGFR10.83521705
93WEE10.82880487
94JAK20.82665281
95BMX0.80865404
96RIPK10.79482207
97STK240.79282243
98EGFR0.78700183
99FGFR20.75834496
100NEK10.74485192
101PRKCQ0.74201597
102VRK20.73169336
103MELK0.72734103
104MST40.69900469
105ZAK0.68189497
106KDR0.67041920
107KSR10.66938195
108PDGFRB0.66698316
109MAP3K50.65991132
110YES10.65950266
111LYN0.65906717
112SCYL20.64159552
113ABL10.64064039
114PAK30.63729284
115PLK10.62650427
116FLT30.62587261
117BMPR20.61973795
118IRAK20.61737727
119BRD40.61143956
120ALK0.60370388
121PAK40.60165107
122PAK20.59443240
123PDGFRA0.59404559
124DDR20.58698350
125CDK120.58452619
126IRAK10.56792955
127FES0.56377786
128MAPKAPK20.55119161
129MUSK0.54590414
130IGF1R0.53888109
131MAP3K80.52229309
132ADRBK20.52019220
133CDK40.50811456
134FYN0.49644437
135DYRK1B0.49165737
136CSNK1G10.49097791
137GSK3A0.48980179
138NLK0.48386825
139PDK20.48314323
140INSR0.47600956
141VRK10.46984402
142ABL20.46279900
143RPS6KB20.45453446
144GRK60.42718772
145MAP3K130.42548664
146AKT30.42411842
147IRAK30.41729608
148MAPK40.41188942
149GRK70.39842376
150FGR0.36413884
151PRKCI0.34320185
152ROCK20.33401338
153PRKCE0.32176442
154ATM0.31658658
155MAPK130.30613559
156DYRK30.29499070
157PASK0.29301969
158PIK3CA0.28537662
159MINK10.24757306
160ROCK10.22921142
161CDC70.22496346
162CSNK1G20.22109951
163ADRBK10.21547029
164BRSK10.21476673

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82115371
2Non-homologous end-joining_Homo sapiens_hsa034503.62768945
3Protein export_Homo sapiens_hsa030603.59344127
4Staphylococcus aureus infection_Homo sapiens_hsa051503.16544567
5Leishmaniasis_Homo sapiens_hsa051402.69353401
6Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.68418032
7Propanoate metabolism_Homo sapiens_hsa006402.61744149
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36430717
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34301792
10Basal transcription factors_Homo sapiens_hsa030222.14178748
11RNA degradation_Homo sapiens_hsa030182.11732710
12Homologous recombination_Homo sapiens_hsa034402.10093324
13Graft-versus-host disease_Homo sapiens_hsa053322.09338775
14Osteoclast differentiation_Homo sapiens_hsa043802.05289493
15Nitrogen metabolism_Homo sapiens_hsa009102.01358675
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99624099
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99012450
18Complement and coagulation cascades_Homo sapiens_hsa046101.97689250
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.93712152
20Viral myocarditis_Homo sapiens_hsa054161.90228928
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.85352680
22RNA transport_Homo sapiens_hsa030131.80667915
23Fanconi anemia pathway_Homo sapiens_hsa034601.80440639
24Vitamin B6 metabolism_Homo sapiens_hsa007501.77921039
25Pertussis_Homo sapiens_hsa051331.74846497
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.74440753
27Allograft rejection_Homo sapiens_hsa053301.66415492
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65914182
29B cell receptor signaling pathway_Homo sapiens_hsa046621.65767280
30Measles_Homo sapiens_hsa051621.65656307
31Toxoplasmosis_Homo sapiens_hsa051451.64524561
32Malaria_Homo sapiens_hsa051441.63717438
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.63443833
34Mismatch repair_Homo sapiens_hsa034301.61193226
35Selenocompound metabolism_Homo sapiens_hsa004501.56937569
36Sulfur metabolism_Homo sapiens_hsa009201.56528909
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.55592700
38Legionellosis_Homo sapiens_hsa051341.54943213
39TNF signaling pathway_Homo sapiens_hsa046681.49382485
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.46942484
41Caffeine metabolism_Homo sapiens_hsa002321.45235659
42Fatty acid elongation_Homo sapiens_hsa000621.44358163
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.42141920
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39276234
45T cell receptor signaling pathway_Homo sapiens_hsa046601.37891896
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.37627376
47Tuberculosis_Homo sapiens_hsa051521.36691927
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34323349
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.33932282
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33301343
51Proteoglycans in cancer_Homo sapiens_hsa052051.33127322
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31352385
53Chronic myeloid leukemia_Homo sapiens_hsa052201.31057169
54Small cell lung cancer_Homo sapiens_hsa052221.29344348
55Hepatitis B_Homo sapiens_hsa051611.28862207
56Butanoate metabolism_Homo sapiens_hsa006501.27890021
57Cell cycle_Homo sapiens_hsa041101.27745270
58Shigellosis_Homo sapiens_hsa051311.25302678
59Herpes simplex infection_Homo sapiens_hsa051681.25263945
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.25117841
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.24071365
62Antigen processing and presentation_Homo sapiens_hsa046121.23030840
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22261532
64Influenza A_Homo sapiens_hsa051641.19765714
65Primary immunodeficiency_Homo sapiens_hsa053401.19170527
66Salmonella infection_Homo sapiens_hsa051321.17577523
67Amoebiasis_Homo sapiens_hsa051461.17125670
68Adherens junction_Homo sapiens_hsa045201.16142767
69Glutathione metabolism_Homo sapiens_hsa004801.13219411
70Chemokine signaling pathway_Homo sapiens_hsa040621.13116554
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13018628
72Pancreatic cancer_Homo sapiens_hsa052121.12306431
73Platelet activation_Homo sapiens_hsa046111.11960964
74Jak-STAT signaling pathway_Homo sapiens_hsa046301.11504897
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09714623
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09367623
77Hematopoietic cell lineage_Homo sapiens_hsa046401.09227796
78Arginine biosynthesis_Homo sapiens_hsa002201.09101629
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03286397
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02691445
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01350379
82Apoptosis_Homo sapiens_hsa042100.97507345
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97295778
84Focal adhesion_Homo sapiens_hsa045100.97138466
85MicroRNAs in cancer_Homo sapiens_hsa052060.95580359
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93381996
87Peroxisome_Homo sapiens_hsa041460.92922144
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92162884
89Hepatitis C_Homo sapiens_hsa051600.89687353
90Asthma_Homo sapiens_hsa053100.89566387
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87528934
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86875502
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86394090
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85630487
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84831346
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84770363
97Oocyte meiosis_Homo sapiens_hsa041140.83576677
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82991917
99Acute myeloid leukemia_Homo sapiens_hsa052210.81920098
100One carbon pool by folate_Homo sapiens_hsa006700.81693634
101Autoimmune thyroid disease_Homo sapiens_hsa053200.80093526
102Prostate cancer_Homo sapiens_hsa052150.78771193
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77647859
104Lysine degradation_Homo sapiens_hsa003100.76374433
105mRNA surveillance pathway_Homo sapiens_hsa030150.75281729
106Fatty acid degradation_Homo sapiens_hsa000710.75262094
107Renal cell carcinoma_Homo sapiens_hsa052110.74891332
108ECM-receptor interaction_Homo sapiens_hsa045120.73928874
109RNA polymerase_Homo sapiens_hsa030200.73789514
110TGF-beta signaling pathway_Homo sapiens_hsa043500.72328570
111Insulin resistance_Homo sapiens_hsa049310.72103535
112African trypanosomiasis_Homo sapiens_hsa051430.71347384
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.70962497
114Fatty acid metabolism_Homo sapiens_hsa012120.70406193
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69052969
116Tryptophan metabolism_Homo sapiens_hsa003800.67449252
117Type I diabetes mellitus_Homo sapiens_hsa049400.67171963
118Wnt signaling pathway_Homo sapiens_hsa043100.66603704
119Pyruvate metabolism_Homo sapiens_hsa006200.66388530
120Phagosome_Homo sapiens_hsa041450.66010499
121HTLV-I infection_Homo sapiens_hsa051660.65728713
122VEGF signaling pathway_Homo sapiens_hsa043700.65629500
123Nucleotide excision repair_Homo sapiens_hsa034200.65328703
124Viral carcinogenesis_Homo sapiens_hsa052030.61772600
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61392316
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61044354
127Retinol metabolism_Homo sapiens_hsa008300.60232498
128PPAR signaling pathway_Homo sapiens_hsa033200.58673027
129p53 signaling pathway_Homo sapiens_hsa041150.57178064
130Steroid biosynthesis_Homo sapiens_hsa001000.56802859
131FoxO signaling pathway_Homo sapiens_hsa040680.54146872
132Adipocytokine signaling pathway_Homo sapiens_hsa049200.54031169
133Sphingolipid metabolism_Homo sapiens_hsa006000.53172350
134HIF-1 signaling pathway_Homo sapiens_hsa040660.52498418
135Non-small cell lung cancer_Homo sapiens_hsa052230.51814536
136Colorectal cancer_Homo sapiens_hsa052100.51569422
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.51293897
138Collecting duct acid secretion_Homo sapiens_hsa049660.50568872
139Pathways in cancer_Homo sapiens_hsa052000.49610246
140Spliceosome_Homo sapiens_hsa030400.49247958
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47317540
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47007005
143DNA replication_Homo sapiens_hsa030300.46578348
144Bladder cancer_Homo sapiens_hsa052190.46565754
145Rheumatoid arthritis_Homo sapiens_hsa053230.45932459
146Lysosome_Homo sapiens_hsa041420.44893875
147Prolactin signaling pathway_Homo sapiens_hsa049170.44884816
148Glioma_Homo sapiens_hsa052140.43417594
149Rap1 signaling pathway_Homo sapiens_hsa040150.43196133
150Endocytosis_Homo sapiens_hsa041440.42282570
151Dorso-ventral axis formation_Homo sapiens_hsa043200.41432067
152Chemical carcinogenesis_Homo sapiens_hsa052040.41191731
153Thyroid cancer_Homo sapiens_hsa052160.41026149
154Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40864743
155Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39553303
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38199278
157Hippo signaling pathway_Homo sapiens_hsa043900.38191001
158Sphingolipid signaling pathway_Homo sapiens_hsa040710.37088817
159Endometrial cancer_Homo sapiens_hsa052130.36949640
160beta-Alanine metabolism_Homo sapiens_hsa004100.36705000
161Epstein-Barr virus infection_Homo sapiens_hsa051690.35175550
162Vitamin digestion and absorption_Homo sapiens_hsa049770.34712932
163Purine metabolism_Homo sapiens_hsa002300.33944002
164Circadian rhythm_Homo sapiens_hsa047100.32521062
165Regulation of autophagy_Homo sapiens_hsa041400.30637088
166N-Glycan biosynthesis_Homo sapiens_hsa005100.30293693

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