RAP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinocyte development (GO:0003334)6.07948242
2melanin biosynthetic process (GO:0042438)6.00758623
3negative regulation of dendrite morphogenesis (GO:0050774)5.42684360
4secondary metabolite biosynthetic process (GO:0044550)5.37344583
5protein K11-linked deubiquitination (GO:0035871)5.27557825
6melanin metabolic process (GO:0006582)5.20145575
7neutrophil activation involved in immune response (GO:0002283)5.19195438
8lactate metabolic process (GO:0006089)5.04622481
9proteasome assembly (GO:0043248)4.30668911
10platelet dense granule organization (GO:0060155)4.28815027
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.24393341
12response to peptidoglycan (GO:0032494)4.14304535
13negative regulation of JUN kinase activity (GO:0043508)4.00840270
14neutrophil activation (GO:0042119)3.97937721
15negative regulation of neurological system process (GO:0031645)3.91701237
16granulocyte activation (GO:0036230)3.88430559
17Arp2/3 complex-mediated actin nucleation (GO:0034314)3.88128970
18DNA double-strand break processing (GO:0000729)3.86399237
19superoxide anion generation (GO:0042554)3.84754976
20negative regulation of dendrite development (GO:2000171)3.79748553
21positive regulation by symbiont of host defense response (GO:0052509)3.70327248
22modulation by symbiont of host defense response (GO:0052031)3.70327248
23modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.70327248
24modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.70327248
25positive regulation by organism of defense response of other organism involved in symbiotic interact3.70327248
26modulation by symbiont of host immune response (GO:0052553)3.70327248
27melanosome organization (GO:0032438)3.68862296
28positive regulation of glycoprotein biosynthetic process (GO:0010560)3.63513796
29cullin deneddylation (GO:0010388)3.53877034
30positive regulation of antigen processing and presentation (GO:0002579)3.49570177
31myeloid dendritic cell activation (GO:0001773)3.42441255
32regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.41991760
33respiratory burst (GO:0045730)3.39364190
34myeloid dendritic cell differentiation (GO:0043011)3.35769912
35pigment granule organization (GO:0048753)3.35432284
36response to muramyl dipeptide (GO:0032495)3.34725802
37regulation of sulfur metabolic process (GO:0042762)3.33124739
38negative regulation of cell killing (GO:0031342)3.32760239
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.32760239
40regulation of Rac protein signal transduction (GO:0035020)3.28674694
41DNA deamination (GO:0045006)3.28259359
42myeloid leukocyte mediated immunity (GO:0002444)3.28251888
43regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.27670001
44signal peptide processing (GO:0006465)3.26765849
45DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.25534265
46positive regulation of glycoprotein metabolic process (GO:1903020)3.25302531
47actin nucleation (GO:0045010)3.24975894
48regulation of hexokinase activity (GO:1903299)3.24755079
49regulation of glucokinase activity (GO:0033131)3.24755079
50regulation of antigen processing and presentation (GO:0002577)3.24166289
51regulation of T-helper 1 cell differentiation (GO:0045625)3.24055475
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21663638
53female gonad development (GO:0008585)3.21108696
54immunoglobulin mediated immune response (GO:0016064)3.18152965
55protein K6-linked ubiquitination (GO:0085020)3.17119712
56myeloid cell activation involved in immune response (GO:0002275)3.16512854
57neutrophil mediated immunity (GO:0002446)3.16198551
58protein deneddylation (GO:0000338)3.16151223
59amine catabolic process (GO:0009310)3.15886235
60cellular biogenic amine catabolic process (GO:0042402)3.15886235
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15664601
62signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15664601
63signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15664601
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13434875
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13434875
66response to pheromone (GO:0019236)3.10150242
67regulation of B cell receptor signaling pathway (GO:0050855)3.09737979
68inositol phosphate catabolic process (GO:0071545)3.08088470
69nephron tubule formation (GO:0072079)3.05370078
70interferon-gamma-mediated signaling pathway (GO:0060333)3.05311601
71NIK/NF-kappaB signaling (GO:0038061)3.04011876
72negative regulation of protein autophosphorylation (GO:0031953)3.02995883
73polyol catabolic process (GO:0046174)3.00917989
74negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.99812173
75regulation of acyl-CoA biosynthetic process (GO:0050812)2.99750783
76positive regulation of macrophage differentiation (GO:0045651)2.98552349
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.96720873
78signal transduction involved in DNA damage checkpoint (GO:0072422)2.96720873
79positive regulation of cellular amide metabolic process (GO:0034250)2.96619247
80positive regulation of interferon-alpha production (GO:0032727)2.96088438
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.95058056
82signal transduction involved in cell cycle checkpoint (GO:0072395)2.94809452
83dendritic cell differentiation (GO:0097028)2.94139621
84lymphocyte chemotaxis (GO:0048247)2.93979554
85macrophage activation involved in immune response (GO:0002281)2.93679711
86respiratory chain complex IV assembly (GO:0008535)2.91512950
87regulation of DNA endoreduplication (GO:0032875)2.90381214
88dendritic cell chemotaxis (GO:0002407)2.89158565
89regulation of integrin-mediated signaling pathway (GO:2001044)2.88659341
90microglial cell activation (GO:0001774)2.86712698
91detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86365608
92reactive oxygen species biosynthetic process (GO:1903409)2.86270428
93hydrogen peroxide biosynthetic process (GO:0050665)2.86152017
94positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.85092630
95monocyte chemotaxis (GO:0002548)2.84518039
96hepatocyte apoptotic process (GO:0097284)2.84264265
97negative regulation of interleukin-17 production (GO:0032700)2.82962303
98histamine secretion (GO:0001821)2.82408419
99protein neddylation (GO:0045116)2.81908628
100ketone body metabolic process (GO:1902224)2.81346316
101somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80892607
102somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80892607
103isotype switching (GO:0045190)2.80892607
104myeloid leukocyte activation (GO:0002274)2.80464526
105regulation of interferon-alpha production (GO:0032647)2.80461358
106negative regulation of signal transduction by p53 class mediator (GO:1901797)2.80149669
107limb bud formation (GO:0060174)2.79631813
108regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.79256475
109developmental pigmentation (GO:0048066)2.79190405
110negative regulation of calcium ion transport into cytosol (GO:0010523)2.78592059
111inositol phosphate dephosphorylation (GO:0046855)2.78359007
112phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78359007
113regulation of cellular amino acid metabolic process (GO:0006521)2.76162574
114leukocyte degranulation (GO:0043299)2.75859187
115replication fork processing (GO:0031297)2.75449741
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75230370
117single strand break repair (GO:0000012)2.74852163
118germinal center formation (GO:0002467)2.73802958
119positive regulation of lymphocyte migration (GO:2000403)2.72924628
120positive regulation of interleukin-12 production (GO:0032735)2.72914947
121dendritic cell migration (GO:0036336)2.72019194
122sequestering of actin monomers (GO:0042989)2.71113874
123L-fucose catabolic process (GO:0042355)2.71009375
124fucose catabolic process (GO:0019317)2.71009375
125L-fucose metabolic process (GO:0042354)2.71009375
126membrane invagination (GO:0010324)2.70607432
127positive regulation of mast cell activation (GO:0033005)2.69149973
128positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.67731291
129cellular response to zinc ion (GO:0071294)2.67462640
130mast cell activation (GO:0045576)2.67296892
131synapsis (GO:0007129)2.66202449
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65246888
133blastocyst development (GO:0001824)2.64828524
134protein prenylation (GO:0018342)2.64818760
135prenylation (GO:0097354)2.64818760
136regulation of mast cell degranulation (GO:0043304)2.64798134
137negative regulation of viral genome replication (GO:0045071)2.63878620
138positive regulation of T cell migration (GO:2000406)2.62866971
139positive regulation of monocyte chemotaxis (GO:0090026)2.61134121
140regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.60434757
141regulation of fever generation (GO:0031620)2.59446708
142regulation of cofactor metabolic process (GO:0051193)2.59029601
143regulation of coenzyme metabolic process (GO:0051196)2.59029601
144DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.58930981
145recombinational repair (GO:0000725)2.58207765
146negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.58162299
147B cell mediated immunity (GO:0019724)2.57855259
148regulation of mast cell activation (GO:0033003)2.57824149
149double-strand break repair via homologous recombination (GO:0000724)2.57430149
150phagocytosis, engulfment (GO:0006911)2.56163898
151dopamine transport (GO:0015872)2.55810936
152cellular response to interferon-beta (GO:0035458)2.55187901
153S-adenosylmethionine metabolic process (GO:0046500)2.54660557
154eosinophil chemotaxis (GO:0048245)2.54447035
155positive regulation of heat generation (GO:0031652)2.54376332
156positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54058348
157piRNA metabolic process (GO:0034587)2.53596931
158response to interferon-beta (GO:0035456)2.53104928
159negative regulation of granulocyte differentiation (GO:0030853)2.50934757
160negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.50642733
161leukocyte mediated cytotoxicity (GO:0001909)2.50295562
162cellular response to type I interferon (GO:0071357)2.49789520
163type I interferon signaling pathway (GO:0060337)2.49789520
164regulation of cellular extravasation (GO:0002691)2.48692811
165phenol-containing compound biosynthetic process (GO:0046189)2.47514344
166regulation of interferon-beta biosynthetic process (GO:0045357)2.47282778
167negative regulation of phagocytosis (GO:0050765)2.47033034
168regulation of mast cell activation involved in immune response (GO:0033006)2.46748585
169regulation of mononuclear cell migration (GO:0071675)2.45454529
170regulation of lymphocyte chemotaxis (GO:1901623)2.44771829
171response to type I interferon (GO:0034340)2.44719401
172negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.44379534
173positive regulation of T cell chemotaxis (GO:0010820)2.44323800
174regulation of T cell chemotaxis (GO:0010819)2.44323800
175regulation of RIG-I signaling pathway (GO:0039535)2.43601205
176response to host immune response (GO:0052572)2.42776340
177response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.42776340
178glial cell proliferation (GO:0014009)2.42353672
179macrophage activation (GO:0042116)2.42242756
180cytochrome complex assembly (GO:0017004)2.41846384
181positive regulation of cell size (GO:0045793)2.41807500
182regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.41702266
183mature B cell differentiation (GO:0002335)2.40849307
184defense response to protozoan (GO:0042832)2.40347832
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.40125766
186positive regulation of mast cell degranulation (GO:0043306)2.40125766
187genitalia morphogenesis (GO:0035112)2.38717859
188RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38701004
189transcytosis (GO:0045056)2.38665650
190leukocyte mediated immunity (GO:0002443)2.38597695
191DNA catabolic process, exonucleolytic (GO:0000738)2.38579429
192anterograde synaptic vesicle transport (GO:0048490)2.38370617
193anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.38215466
194adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.37981234
195regulation of T-helper 2 cell differentiation (GO:0045628)2.37229283
196positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.37118163
197response to interferon-alpha (GO:0035455)2.36957310
198T cell migration (GO:0072678)2.36795565

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.27127775
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.32133844
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.67263734
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.22591623
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.83445184
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.80958515
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.53220609
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.29059723
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.22434940
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.09232989
11MYB_21317192_ChIP-Seq_ERMYB_Mouse3.07494639
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04091623
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.00784052
14* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.94071858
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89210513
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79600184
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.70273046
18VDR_22108803_ChIP-Seq_LS180_Human2.60495520
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.56309432
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.53423094
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.53001140
22* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.45066676
23IGF1R_20145208_ChIP-Seq_DFB_Human2.44936006
24EZH2_22144423_ChIP-Seq_EOC_Human2.23619506
25SPI1_23547873_ChIP-Seq_NB4_Human2.17365554
26GABP_17652178_ChIP-ChIP_JURKAT_Human2.14005705
27ZNF274_21170338_ChIP-Seq_K562_Hela2.12821107
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.12139889
29FUS_26573619_Chip-Seq_HEK293_Human2.09618607
30VDR_24787735_ChIP-Seq_THP-1_Human2.04994646
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99975301
32EWS_26573619_Chip-Seq_HEK293_Human1.95676895
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88667296
34PU_27001747_Chip-Seq_BMDM_Mouse1.87412148
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.85662377
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.84765058
37RUNX_20019798_ChIP-Seq_JUKART_Human1.79341318
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.73906093
39VDR_24763502_ChIP-Seq_THP-1_Human1.69509543
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68644416
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66807429
42MYB_26560356_Chip-Seq_TH2_Human1.62794172
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61772630
44BCAT_22108803_ChIP-Seq_LS180_Human1.61733131
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61588117
46* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.59989193
47SCL_19346495_ChIP-Seq_HPC-7_Human1.59696741
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56383808
49SPI1_23127762_ChIP-Seq_K562_Human1.56317052
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.56189819
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.52887107
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52846556
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52259255
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50732851
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49643539
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49342246
57CDX2_22108803_ChIP-Seq_LS180_Human1.49181626
58CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.48510583
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.48246757
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.47942453
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47036390
62NANOG_19829295_ChIP-Seq_ESCs_Human1.44360381
63SOX2_19829295_ChIP-Seq_ESCs_Human1.44360381
64* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42942951
65* RUNX1_22412390_ChIP-Seq_EML_Mouse1.41770836
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40598689
67ELK1_19687146_ChIP-ChIP_HELA_Human1.40395014
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.40387495
69MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40003352
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.39716584
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39648050
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39410677
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.36362393
74* CJUN_26792858_Chip-Seq_BT549_Human1.35758267
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34596065
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33984583
77* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33615205
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31663119
79VDR_23849224_ChIP-Seq_CD4+_Human1.30254949
80* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29662392
81* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28757204
82* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28706437
83FOXA1_21572438_ChIP-Seq_LNCaP_Human1.28238685
84TAF15_26573619_Chip-Seq_HEK293_Human1.27724291
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27180236
86GATA1_22025678_ChIP-Seq_K562_Human1.26787905
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26747098
88* NANOG_18555785_Chip-Seq_ESCs_Mouse1.26538760
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26382859
90* TCF4_22108803_ChIP-Seq_LS180_Human1.25610785
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25363890
92EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23784912
93* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23124840
94MAF_26560356_Chip-Seq_TH1_Human1.23065035
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22340169
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.22328507
97SMAD4_21799915_ChIP-Seq_A2780_Human1.21041636
98SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20869258
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20296370
100OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20283631
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17661418
102AR_25329375_ChIP-Seq_VCAP_Human1.16217602
103* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16074443
104CBP_20019798_ChIP-Seq_JUKART_Human1.15912653
105IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15912653
106MYB_26560356_Chip-Seq_TH1_Human1.15758852
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15691183
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13211535
109ESR1_21235772_ChIP-Seq_MCF-7_Human1.10230553
110* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.09974079
111BRD4_25478319_ChIP-Seq_HGPS_Human1.09781620
112* TP53_18474530_ChIP-ChIP_U2OS_Human1.09613025
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09497011
114PHF8_20622853_ChIP-Seq_HELA_Human1.09442747
115SMAD4_21741376_ChIP-Seq_EPCs_Human1.08226254
116CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08025893
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.06744809
118OCT4_18555785_Chip-Seq_ESCs_Mouse1.06315543
119RBPJ_21746931_ChIP-Seq_IB4_Human1.06010786
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05934316
121* SOX2_18555785_Chip-Seq_ESCs_Mouse1.05761902
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.05488333
123FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05488333
124SALL4_22934838_ChIP-ChIP_CD34+_Human1.04555658
125GBX2_23144817_ChIP-Seq_PC3_Human1.03365261
126CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03280178
127CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02810690
128CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02744978
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00108110
130FLI1_27457419_Chip-Seq_LIVER_Mouse0.99781211
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97321716
132P300_19829295_ChIP-Seq_ESCs_Human0.97109664
133* VDR_21846776_ChIP-Seq_THP-1_Human0.97100898
134NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97032780
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97032780
136* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94636808
137GATA3_26560356_Chip-Seq_TH2_Human0.92353730
138LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91791733
139CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90404737
140CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89741708
141JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89422463
142* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88405698
143GATA2_21666600_ChIP-Seq_HMVEC_Human0.87430897
144EGR1_19032775_ChIP-ChIP_M12_Human0.86055609
145* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84182488
146PU1_27457419_Chip-Seq_LIVER_Mouse0.83354143
147* E2F1_18555785_Chip-Seq_ESCs_Mouse0.82606709
148STAT3_18555785_Chip-Seq_ESCs_Mouse0.82041397
149SUZ12_18555785_Chip-Seq_ESCs_Mouse0.81946734
150* P53_22387025_ChIP-Seq_ESCs_Mouse0.81637526
151NMYC_18555785_Chip-Seq_ESCs_Mouse0.81103977
152CMYC_18555785_Chip-Seq_ESCs_Mouse0.81080219
153PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80453437
154P300_18555785_Chip-Seq_ESCs_Mouse0.80364901
155* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80178950
156GATA3_27048872_Chip-Seq_THYMUS_Human0.78745914
157* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77331988
158E2F7_22180533_ChIP-Seq_HELA_Human0.76697305
159* SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.76557213
160SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76170491
161PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.75991217
162* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75702912
163* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75702912
164ER_23166858_ChIP-Seq_MCF-7_Human0.75305035
165THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.74543000
166* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74353697
167HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74268656
168GATA2_22383799_ChIP-Seq_G1ME_Mouse0.73587011
169EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.72903269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage4.57898404
2MP0001835_abnormal_antigen_presentation3.86836020
3MP0002102_abnormal_ear_morphology3.42256646
4MP0002148_abnormal_hypersensitivity_rea3.33441708
5MP0008057_abnormal_DNA_replication3.31544328
6MP0003195_calcinosis3.15027337
7MP0003436_decreased_susceptibility_to3.13018024
8MP0003950_abnormal_plasma_membrane3.12267511
9MP0003303_peritoneal_inflammation3.12180051
10MP0005174_abnormal_tail_pigmentation2.74180964
11MP0009785_altered_susceptibility_to2.74041502
12MP0003806_abnormal_nucleotide_metabolis2.72930808
13MP0000015_abnormal_ear_pigmentation2.72312309
14MP0005000_abnormal_immune_tolerance2.68443691
15MP0002419_abnormal_innate_immunity2.53256486
16MP0009379_abnormal_foot_pigmentation2.45590679
17MP0002138_abnormal_hepatobiliary_system2.44321850
18MP0005671_abnormal_response_to2.41512452
19MP0000685_abnormal_immune_system2.38581274
20MP0001790_abnormal_immune_system2.30869656
21MP0005387_immune_system_phenotype2.30869656
22MP0002452_abnormal_antigen_presenting2.21846346
23MP0005025_abnormal_response_to2.19977413
24MP0003724_increased_susceptibility_to2.16484657
25MP0003136_yellow_coat_color2.15299321
26MP0005670_abnormal_white_adipose2.09004891
27MP0008058_abnormal_DNA_repair2.07282632
28MP0001819_abnormal_immune_cell2.06295370
29MP0002420_abnormal_adaptive_immunity2.04810733
30MP0002723_abnormal_immune_serum2.04278551
31MP0000372_irregular_coat_pigmentation1.99352280
32MP0001800_abnormal_humoral_immune1.96578261
33MP0002006_tumorigenesis1.94324793
34MP0004510_myositis1.90195962
35MP0005171_absent_coat_pigmentation1.89931520
36MP0002938_white_spotting1.89712491
37MP0000569_abnormal_digit_pigmentation1.88621892
38MP0010234_abnormal_vibrissa_follicle1.86066063
39MP0001188_hyperpigmentation1.80073400
40MP0003880_abnormal_central_pattern1.78623489
41MP0008877_abnormal_DNA_methylation1.75052106
42MP0002166_altered_tumor_susceptibility1.74211580
43MP0006082_CNS_inflammation1.70029218
44MP0003786_premature_aging1.69769840
45MP0002009_preneoplasia1.68658770
46MP0001324_abnormal_eye_pigmentation1.66697944
47MP0001853_heart_inflammation1.62786252
48MP0002095_abnormal_skin_pigmentation1.62219750
49MP0003448_altered_tumor_morphology1.60421325
50MP0010094_abnormal_chromosome_stability1.60359354
51MP0005058_abnormal_lysosome_morphology1.60087935
52MP0002277_abnormal_respiratory_mucosa1.57731969
53MP0001533_abnormal_skeleton_physiology1.55923119
54MP0005377_hearing/vestibular/ear_phenot1.55752148
55MP0003878_abnormal_ear_physiology1.55752148
56MP0005310_abnormal_salivary_gland1.55697519
57MP0001348_abnormal_lacrimal_gland1.52832437
58MP0005464_abnormal_platelet_physiology1.48187965
59MP0003718_maternal_effect1.47509905
60MP0002090_abnormal_vision1.47038112
61MP0000516_abnormal_urinary_system1.46224654
62MP0005367_renal/urinary_system_phenotyp1.46224654
63MP0000716_abnormal_immune_system1.44680557
64MP0000858_altered_metastatic_potential1.43233243
65MP0002398_abnormal_bone_marrow1.42935432
66MP0002163_abnormal_gland_morphology1.38843740
67MP0005409_darkened_coat_color1.38724757
68MP0009333_abnormal_splenocyte_physiolog1.38556575
69MP0002405_respiratory_system_inflammati1.37544549
70MP0000613_abnormal_salivary_gland1.36859018
71MP0003186_abnormal_redox_activity1.35700707
72MP0006292_abnormal_olfactory_placode1.33599646
73MP0000647_abnormal_sebaceous_gland1.30252171
74MP0002282_abnormal_trachea_morphology1.28358762
75MP0005075_abnormal_melanosome_morpholog1.27003920
76MP0001485_abnormal_pinna_reflex1.26718487
77MP0005167_abnormal_blood-brain_barrier1.26183220
78MP0006036_abnormal_mitochondrial_physio1.24991792
79MP0003763_abnormal_thymus_physiology1.22694191
80MP0000427_abnormal_hair_cycle1.22614638
81MP0003828_pulmonary_edema1.20820014
82MP0002998_abnormal_bone_remodeling1.20783056
83MP0004484_altered_response_of1.18258725
84MP0003646_muscle_fatigue1.18028746
85MP0010155_abnormal_intestine_physiology1.16402211
86MP0003172_abnormal_lysosome_physiology1.15557681
87MP0005253_abnormal_eye_physiology1.15347068
88MP0000689_abnormal_spleen_morphology1.14536284
89MP0001845_abnormal_inflammatory_respons1.13502081
90MP0000490_abnormal_crypts_of1.11187678
91MP0002429_abnormal_blood_cell1.08582375
92MP0000343_altered_response_to1.07026350
93MP0008872_abnormal_physiological_respon1.05202214
94MP0002722_abnormal_immune_system1.03816673
95MP0005551_abnormal_eye_electrophysiolog1.03434012
96MP0000371_diluted_coat_color1.01415573
97MP0005187_abnormal_penis_morphology1.00348169
98MP0001545_abnormal_hematopoietic_system1.00279880
99MP0005397_hematopoietic_system_phenotyp1.00279880
100MP0003943_abnormal_hepatobiliary_system0.99584737
101MP0004808_abnormal_hematopoietic_stem0.97994291
102MP0002877_abnormal_melanocyte_morpholog0.95932962
103MP0003075_altered_response_to0.95102863
104MP0004859_abnormal_synaptic_plasticity0.93936052
105MP0005395_other_phenotype0.92389599
106MP0008260_abnormal_autophagy0.91726423
107MP0005390_skeleton_phenotype0.91296042
108MP0002638_abnormal_pupillary_reflex0.89878080
109MP0003091_abnormal_cell_migration0.89591311
110MP0009764_decreased_sensitivity_to0.87083686
111MP0005257_abnormal_intraocular_pressure0.86546072
112MP0004381_abnormal_hair_follicle0.86504911
113MP0004947_skin_inflammation0.86313297
114MP0000681_abnormal_thyroid_gland0.86135307
115MP0002933_joint_inflammation0.85477378
116MP0008875_abnormal_xenobiotic_pharmacok0.84789409
117MP0001346_abnormal_lacrimal_gland0.84659874
118MP0003077_abnormal_cell_cycle0.84031488
119MP0002254_reproductive_system_inflammat0.82761929
120MP0002075_abnormal_coat/hair_pigmentati0.81885848
121MP0001186_pigmentation_phenotype0.81524372
122MP0005410_abnormal_fertilization0.80888016
123MP0008469_abnormal_protein_level0.79975083
124MP0005084_abnormal_gallbladder_morpholo0.79518084
125MP0008007_abnormal_cellular_replicative0.79482337
126MP0005076_abnormal_cell_differentiation0.75295696
127MP0003137_abnormal_impulse_conducting0.74568130
128MP0002396_abnormal_hematopoietic_system0.72984357
129MP0010678_abnormal_skin_adnexa0.72280386
130MP0003941_abnormal_skin_development0.69646458
131MP0004085_abnormal_heartbeat0.69406993
132MP0002751_abnormal_autonomic_nervous0.69386722
133MP0000749_muscle_degeneration0.69234022
134MP0000703_abnormal_thymus_morphology0.67595412
135MP0002168_other_aberrant_phenotype0.67161829
136MP0003890_abnormal_embryonic-extraembry0.66890497
137MP0004147_increased_porphyrin_level0.66833897
138MP0005248_abnormal_Harderian_gland0.66156852
139MP0005408_hypopigmentation0.66149922
140MP0005379_endocrine/exocrine_gland_phen0.65013104
141MP0009840_abnormal_foam_cell0.64731962
142MP0010352_gastrointestinal_tract_polyps0.64508521
143MP0002177_abnormal_outer_ear0.63251008
144MP0009697_abnormal_copulation0.63041894
145MP0000465_gastrointestinal_hemorrhage0.62394109
146MP0001851_eye_inflammation0.62365302
147MP0003111_abnormal_nucleus_morphology0.62032739
148MP0001984_abnormal_olfaction0.61740871
149MP0010307_abnormal_tumor_latency0.61083816
150MP0003787_abnormal_imprinting0.60535300
151MP0005197_abnormal_uvea_morphology0.60184120
152MP0005164_abnormal_response_to0.59485630
153MP0000604_amyloidosis0.59185073
154MP0003453_abnormal_keratinocyte_physiol0.58388863
155MP0005220_abnormal_exocrine_pancreas0.58111100
156MP0008995_early_reproductive_senescence0.57982274
157MP0005166_decreased_susceptibility_to0.57524267
158MP0009745_abnormal_behavioral_response0.57447817
159MP0001929_abnormal_gametogenesis0.56876105
160MP0001529_abnormal_vocalization0.56831517
161MP0000538_abnormal_urinary_bladder0.56433890
162MP0003755_abnormal_palate_morphology0.55961649
163MP0005647_abnormal_sex_gland0.55788704
164MP0001119_abnormal_female_reproductive0.52507278
165MP0003937_abnormal_limbs/digits/tail_de0.52334843
166MP0004133_heterotaxia0.51582769
167MP0001756_abnormal_urination0.51062993
168MP0005083_abnormal_biliary_tract0.50792462
169MP0005332_abnormal_amino_acid0.49800126
170MP0008873_increased_physiological_sensi0.49734455
171MP0004215_abnormal_myocardial_fiber0.49591119
172MP0003656_abnormal_erythrocyte_physiolo0.48511161
173MP0004019_abnormal_vitamin_homeostasis0.47242524

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.95629804
2Eczematoid dermatitis (HP:0000976)5.25661283
3Recurrent bacterial skin infections (HP:0005406)5.17437867
4Mediastinal lymphadenopathy (HP:0100721)4.55367106
5Hypoplasia of the fovea (HP:0007750)4.27002721
6Aplasia/Hypoplasia of the fovea (HP:0008060)4.27002721
7Myositis (HP:0100614)4.15130607
8Obstructive lung disease (HP:0006536)4.11152195
9Chronic obstructive pulmonary disease (HP:0006510)4.11152195
10Stomatitis (HP:0010280)4.05864143
11Abnormality of macrophages (HP:0004311)3.99075281
12Retrobulbar optic neuritis (HP:0100654)3.98665448
13Optic neuritis (HP:0100653)3.98665448
14Elevated erythrocyte sedimentation rate (HP:0003565)3.97457660
15Aplasia/Hypoplasia of the macula (HP:0008059)3.85649067
16Orchitis (HP:0100796)3.66854914
17Abnormality of the fovea (HP:0000493)3.62325106
18Aplasia/Hypoplasia affecting the retina (HP:0008061)3.54787518
19Congenital stationary night blindness (HP:0007642)3.41368806
20Intestinal atresia (HP:0011100)3.40284161
21Vacuolated lymphocytes (HP:0001922)3.35190500
22Neoplasm of the adrenal cortex (HP:0100641)3.35160412
23Recurrent gram-negative bacterial infections (HP:0005420)3.32247288
24White forelock (HP:0002211)3.10102139
25Prostate neoplasm (HP:0100787)3.09155195
26Meningitis (HP:0001287)3.03965289
27Recurrent skin infections (HP:0001581)3.03690793
28Generalized hypopigmentation (HP:0007513)3.02875547
29Breast carcinoma (HP:0003002)3.02431039
30Recurrent fungal infections (HP:0002841)3.01271198
31Reduced antithrombin III activity (HP:0001976)2.99295961
32Follicular hyperkeratosis (HP:0007502)2.93870486
33Abnormal auditory evoked potentials (HP:0006958)2.92628856
34Gingivitis (HP:0000230)2.91809118
35Decreased central vision (HP:0007663)2.85812562
36Increased IgM level (HP:0003496)2.82848654
37Type I transferrin isoform profile (HP:0003642)2.80014132
38Basal ganglia calcification (HP:0002135)2.76398911
39Agnosia (HP:0010524)2.76031512
40Increased cerebral lipofuscin (HP:0011813)2.68723055
41Sensory axonal neuropathy (HP:0003390)2.68472334
42Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.66486523
43Increased neuronal autofluorescent lipopigment (HP:0002074)2.64817206
44Pulmonary infiltrates (HP:0002113)2.64504023
45Periodontitis (HP:0000704)2.64268695
46Alopecia of scalp (HP:0002293)2.62513322
47Vasculitis (HP:0002633)2.61750050
48Abnormality of the prostate (HP:0008775)2.60888778
49Blue irides (HP:0000635)2.60422882
50Progressive macrocephaly (HP:0004481)2.60056703
51Cellulitis (HP:0100658)2.57312892
52True hermaphroditism (HP:0010459)2.50199943
53Absent frontal sinuses (HP:0002688)2.49914042
54Thick nail (HP:0001805)2.48876867
55Hypothermia (HP:0002045)2.47239063
56Abnormality of the columella (HP:0009929)2.46067481
57Leukocytosis (HP:0001974)2.45821122
58Sparse eyelashes (HP:0000653)2.43727988
59Neoplasm of the adrenal gland (HP:0100631)2.43666118
60Keratoconjunctivitis sicca (HP:0001097)2.39334493
61Chronic mucocutaneous candidiasis (HP:0002728)2.37330374
62Recurrent cutaneous fungal infections (HP:0011370)2.37330374
63Chronic otitis media (HP:0000389)2.35290109
64Vascular calcification (HP:0004934)2.34921226
65Progressive inability to walk (HP:0002505)2.31108991
66Acute encephalopathy (HP:0006846)2.30663879
67Eosinophilia (HP:0001880)2.30630846
68Recurrent viral infections (HP:0004429)2.30276727
69Acute necrotizing encephalopathy (HP:0006965)2.27466016
70Generalized hypopigmentation of hair (HP:0011358)2.27190555
71Stenosis of the external auditory canal (HP:0000402)2.26485569
72Vertebral compression fractures (HP:0002953)2.26047306
73Pancreatic cysts (HP:0001737)2.24957654
74Recurrent pneumonia (HP:0006532)2.23955269
75Ocular albinism (HP:0001107)2.23921154
76Gaze-evoked nystagmus (HP:0000640)2.22035299
77Hypergammaglobulinemia (HP:0010702)2.21258066
78Stomach cancer (HP:0012126)2.20387128
79Autoimmune thrombocytopenia (HP:0001973)2.19921189
80Keratoconjunctivitis (HP:0001096)2.18740614
81Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.17255208
82Disinhibition (HP:0000734)2.16302833
83Arterial thrombosis (HP:0004420)2.15630598
84Heterochromia iridis (HP:0001100)2.12818513
85Congenital sensorineural hearing impairment (HP:0008527)2.12685542
86Glomerulopathy (HP:0100820)2.12603439
87Increased CSF lactate (HP:0002490)2.12195913
88Abnormality of dental color (HP:0011073)2.11837373
89Osteomyelitis (HP:0002754)2.10168715
90Hypoproteinemia (HP:0003075)2.09932307
91Thyroiditis (HP:0100646)2.09233067
92Granulocytopenia (HP:0001913)2.08411363
93Cutaneous melanoma (HP:0012056)2.07679107
94Systemic lupus erythematosus (HP:0002725)2.07283696
95Hemoptysis (HP:0002105)2.06071755
96Congenital, generalized hypertrichosis (HP:0004540)2.05697648
97Thrombocytosis (HP:0001894)2.04534678
98Volvulus (HP:0002580)2.03619445
99Abnormality of macular pigmentation (HP:0008002)2.02699844
100Syringomyelia (HP:0003396)2.02164740
101Spinal cord lesions (HP:0100561)2.02164740
102Hamartoma of the eye (HP:0010568)2.01382580
103Abnormality of chromosome stability (HP:0003220)2.00526582
104Freckling (HP:0001480)1.99269867
105Iris hypopigmentation (HP:0007730)1.99238376
106Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98884679
107Abnormal delayed hypersensitivity skin test (HP:0002963)1.98487047
108Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.96200513
109Molar tooth sign on MRI (HP:0002419)1.96122357
110Abnormality of midbrain morphology (HP:0002418)1.96122357
111Cardiovascular calcification (HP:0011915)1.95957594
112Obstructive sleep apnea (HP:0002870)1.95370736
113Abnormality of methionine metabolism (HP:0010901)1.95323545
114Disproportionate short-trunk short stature (HP:0003521)1.95143137
115Agammaglobulinemia (HP:0004432)1.94704398
116Mitochondrial inheritance (HP:0001427)1.94346747
117Exertional dyspnea (HP:0002875)1.93796959
118Recurrent lower respiratory tract infections (HP:0002783)1.93608819
119Dyschromatopsia (HP:0007641)1.93546549
120Abnormality of the frontal sinuses (HP:0002687)1.93019786
121Tongue fasciculations (HP:0001308)1.92878988
122Abolished electroretinogram (ERG) (HP:0000550)1.92392197
123Hypophosphatemic rickets (HP:0004912)1.91784865
124Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90613005
125Focal motor seizures (HP:0011153)1.90227992
126Abnormality of glycolipid metabolism (HP:0010969)1.89827911
127Abnormality of liposaccharide metabolism (HP:0010968)1.89827911
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.89827911
129Pustule (HP:0200039)1.88630234
130Sepsis (HP:0100806)1.88023389
131Pulmonary artery stenosis (HP:0004415)1.87838240
132Pulmonary fibrosis (HP:0002206)1.87553653
133Abnormality of eosinophils (HP:0001879)1.87534496
134Methylmalonic acidemia (HP:0002912)1.87426301
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.83788543
136Anhidrosis (HP:0000970)1.83434629
137Albinism (HP:0001022)1.82576029
138Adrenal hypoplasia (HP:0000835)1.81090581
139Melanoma (HP:0002861)1.81023485
140Hematochezia (HP:0002573)1.80295068
141Subacute progressive viral hepatitis (HP:0006572)1.79765690
142Inappropriate behavior (HP:0000719)1.78123615
143Aqueductal stenosis (HP:0002410)1.78029061
144Petechiae (HP:0000967)1.77911542
145Porencephaly (HP:0002132)1.77852429
146Posterior subcapsular cataract (HP:0007787)1.77425394
147Urticaria (HP:0001025)1.77361988
148Abnormality of male internal genitalia (HP:0000022)1.77322670
149Chest pain (HP:0100749)1.76251375
150Premature loss of primary teeth (HP:0006323)1.75307162
151Patchy hypopigmentation of hair (HP:0011365)1.74383752
152Encephalitis (HP:0002383)1.74079091
153Gastrointestinal infarctions (HP:0005244)1.73861412
154Gastrointestinal atresia (HP:0002589)1.72749141
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.72001731
156Abnormal protein N-linked glycosylation (HP:0012347)1.72001731
157Abnormal protein glycosylation (HP:0012346)1.72001731
158Abnormal glycosylation (HP:0012345)1.72001731
159Pancreatic fibrosis (HP:0100732)1.71910583
160Axonal loss (HP:0003447)1.71743096
161Microretrognathia (HP:0000308)1.71603215
162Abnormal mitochondria in muscle tissue (HP:0008316)1.71443608
163Abnormality of renal resorption (HP:0011038)1.70815404
164Meckel diverticulum (HP:0002245)1.70692275
165Abnormality of the ileum (HP:0001549)1.69956085
166Prolonged bleeding time (HP:0003010)1.67613437
167Median cleft lip (HP:0000161)1.67283229
168Abnormal lung lobation (HP:0002101)1.67155425
169Hypoplastic iliac wings (HP:0002866)1.67139456
170Abnormality of the nasal septum (HP:0000419)1.67110698
171Conjunctival hamartoma (HP:0100780)1.66885248
172Fair hair (HP:0002286)1.66597483
173Abnormality of the duodenum (HP:0002246)1.66579652
174Atonic seizures (HP:0010819)1.66511027
175Bifid tongue (HP:0010297)1.66500766
176Abnormality of the preputium (HP:0100587)1.66409065
177Diminished motivation (HP:0000745)1.66391690
178Abnormality of the renal cortex (HP:0011035)1.66242096
179Abnormality of glycolysis (HP:0004366)1.65556148
180Clubbing of toes (HP:0100760)1.64920016
181Hypokinesia (HP:0002375)1.64264617
182Medial flaring of the eyebrow (HP:0010747)1.63759719
183Ependymoma (HP:0002888)1.62645944
184Decreased electroretinogram (ERG) amplitude (HP:0000654)1.61857859
185Metaphyseal dysplasia (HP:0100255)1.59585442
186Astigmatism (HP:0000483)1.59230831
187Abnormality of the anterior horn cell (HP:0006802)1.59229839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.31188135
2RIPK43.90906577
3MAP3K143.79007305
4WEE13.70643781
5FRK3.39770363
6BRSK23.37987957
7IRAK43.30038003
8MKNK23.17660845
9EIF2AK32.75462794
10BMPR22.56183307
11CASK2.49757691
12BLK2.45002265
13ACVR1B2.44187426
14PIM22.42036079
15TNIK2.39254837
16MKNK12.35212859
17IRAK32.31219803
18IKBKB2.27010051
19FES2.23804497
20EIF2AK12.23203839
21WNK32.19295285
22GRK12.16474134
23NUAK12.12080602
24BCR1.87030228
25IKBKE1.85737470
26TBK11.82495397
27MAP3K121.80391181
28EIF2AK21.80175397
29NLK1.60953882
30MAP3K131.60903819
31NME21.56252512
32TXK1.54883781
33PLK31.54842532
34FER1.54621909
35JAK31.53895659
36CHUK1.53368589
37KIT1.52219732
38CAMKK21.49673409
39PRPF4B1.49320321
40BUB11.48877730
41YES11.45455789
42EPHA21.45004893
43STK391.44995381
44STK31.44667091
45STK38L1.43394022
46PLK21.39799309
47PDK21.38991178
48TYK21.35581826
49TEC1.34198586
50MAP2K71.33673025
51SIK31.32131503
52STK101.30468955
53BRSK11.30012349
54PIM11.19556970
55SYK1.16486335
56PAK31.15947027
57EPHA41.14768277
58ERBB31.14636051
59CLK11.13268202
60OXSR11.11287436
61IRAK11.06186446
62MUSK1.02702414
63TGFBR21.02119784
64MAP4K21.01777612
65CDK190.99421508
66HCK0.98477747
67VRK20.95308969
68NEK90.94267094
69TLK10.92616458
70CSNK1G10.91292604
71SGK20.90807334
72LYN0.90050985
73ERBB40.89778995
74FGR0.89265941
75TAF10.88531043
76GRK70.87804321
77MST40.86992998
78ADRBK20.86889500
79CSF1R0.85926133
80CSNK1G30.85556900
81ABL20.82133245
82ARAF0.81230109
83PRKCI0.80764756
84DAPK10.79482186
85JAK10.78968792
86IRAK20.78854292
87LCK0.76736922
88CSNK1G20.75897166
89CSNK1A1L0.75426000
90ZAK0.72649588
91ADRBK10.69628998
92GRK50.67693008
93PLK40.67675522
94BCKDK0.67405580
95TSSK60.66425554
96SIK20.65856710
97BTK0.64741286
98FGFR20.64689007
99MAP4K10.64462134
100TGFBR10.62188629
101CSK0.61684824
102ZAP700.61111408
103MAP3K30.60839146
104PLK10.60561776
105BMX0.60377025
106EPHA30.59379634
107TESK20.58463850
108MAPK130.57734459
109PRKCD0.57485117
110CAMKK10.56624290
111STK240.54600807
112MAP3K10.53099040
113TAOK20.52411734
114MOS0.50919637
115CCNB10.50909373
116FGFR30.50508316
117PBK0.50083380
118INSRR0.49937860
119ABL10.48660303
120TESK10.45778021
121DYRK30.45652786
122MAP3K110.44812332
123RPS6KA40.44416231
124DMPK0.44276715
125STK40.43661353
126MELK0.43017773
127PRKCG0.42831541
128DAPK30.42476260
129MYLK0.42451969
130BMPR1B0.41895850
131ROCK10.40667984
132PINK10.39740940
133MINK10.39641749
134PRKCE0.39320015
135SGK30.39096467
136VRK10.38876479
137TAOK30.38520839
138RAF10.37803066
139NTRK30.37704369
140MAP3K50.37567917
141MST1R0.36389637
142SCYL20.35099708
143NEK10.34921613
144FGFR10.34725050
145JAK20.33757364
146MARK30.33696125
147RPS6KA60.33262547
148EGFR0.32998628
149LMTK20.32661321
150PRKCQ0.31567226
151MAPKAPK20.31313512
152CDK60.31089501
153TTK0.31011864
154ATM0.30675871
155PIK3CA0.30324134
156SRPK10.30191976
157PTK2B0.29980502
158DAPK20.29308989
159TRPM70.29177389
160GRK60.28531920
161IGF1R0.28167186
162TIE10.28053186
163MAP2K10.25852562
164CSNK2A10.25354223
165PAK40.25333811
166CSNK1A10.23465279
167PRKAA20.22974454
168STK380.22860921
169KSR10.22683912
170CSNK1D0.22311474
171ATR0.20488211
172WNK40.20365123

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.01358431
2Non-homologous end-joining_Homo sapiens_hsa034503.29503626
3Basal transcription factors_Homo sapiens_hsa030222.44274587
4Leishmaniasis_Homo sapiens_hsa051402.41116156
5Sulfur metabolism_Homo sapiens_hsa009202.39652205
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.33946684
7Homologous recombination_Homo sapiens_hsa034402.30489414
8Graft-versus-host disease_Homo sapiens_hsa053322.30178620
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28419396
10Propanoate metabolism_Homo sapiens_hsa006402.18342508
11Allograft rejection_Homo sapiens_hsa053302.05015390
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97113839
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88765794
14Osteoclast differentiation_Homo sapiens_hsa043801.86307503
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85447527
16Fanconi anemia pathway_Homo sapiens_hsa034601.83830720
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.80208560
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.78207432
19Nitrogen metabolism_Homo sapiens_hsa009101.77757927
20Selenocompound metabolism_Homo sapiens_hsa004501.71931191
21Measles_Homo sapiens_hsa051621.68681137
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.65251075
23Tuberculosis_Homo sapiens_hsa051521.65109177
24Pertussis_Homo sapiens_hsa051331.63872280
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.59584059
26RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54025582
27Rheumatoid arthritis_Homo sapiens_hsa053231.50595289
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.50302441
29Salmonella infection_Homo sapiens_hsa051321.46742506
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46134616
31Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44808399
32Shigellosis_Homo sapiens_hsa051311.44412565
33Malaria_Homo sapiens_hsa051441.43110124
34RNA degradation_Homo sapiens_hsa030181.41877878
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.38683497
36Circadian rhythm_Homo sapiens_hsa047101.36858303
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35505638
38Phototransduction_Homo sapiens_hsa047441.35075655
39TNF signaling pathway_Homo sapiens_hsa046681.34702677
40Fatty acid elongation_Homo sapiens_hsa000621.34659486
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.34634244
42B cell receptor signaling pathway_Homo sapiens_hsa046621.34323444
43Steroid biosynthesis_Homo sapiens_hsa001001.33936470
44Phagosome_Homo sapiens_hsa041451.32166089
45Oxidative phosphorylation_Homo sapiens_hsa001901.31743338
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30915768
47Asthma_Homo sapiens_hsa053101.30641187
48Chemokine signaling pathway_Homo sapiens_hsa040621.28718611
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26943429
50Legionellosis_Homo sapiens_hsa051341.26384691
51Influenza A_Homo sapiens_hsa051641.25653762
52Other glycan degradation_Homo sapiens_hsa005111.23221165
53Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21012352
54Toxoplasmosis_Homo sapiens_hsa051451.20252890
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19123413
56Apoptosis_Homo sapiens_hsa042101.18126179
57Type I diabetes mellitus_Homo sapiens_hsa049401.17854158
58Glutathione metabolism_Homo sapiens_hsa004801.17346858
59Herpes simplex infection_Homo sapiens_hsa051681.16643757
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.16319857
61Autoimmune thyroid disease_Homo sapiens_hsa053201.16130825
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15866170
63African trypanosomiasis_Homo sapiens_hsa051431.15358413
64Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13710748
65RNA polymerase_Homo sapiens_hsa030201.12040681
66Hepatitis B_Homo sapiens_hsa051611.09717088
67Primary immunodeficiency_Homo sapiens_hsa053401.07905981
68Butanoate metabolism_Homo sapiens_hsa006501.07503791
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07493868
70Hematopoietic cell lineage_Homo sapiens_hsa046401.07279771
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06461037
72Caffeine metabolism_Homo sapiens_hsa002321.04687250
73Parkinsons disease_Homo sapiens_hsa050121.04260254
74Antigen processing and presentation_Homo sapiens_hsa046121.03295458
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00717152
76Viral myocarditis_Homo sapiens_hsa054160.96091464
77T cell receptor signaling pathway_Homo sapiens_hsa046600.96084089
78Staphylococcus aureus infection_Homo sapiens_hsa051500.95807786
79Mismatch repair_Homo sapiens_hsa034300.95643859
80Lysosome_Homo sapiens_hsa041420.95606367
81Glycosaminoglycan degradation_Homo sapiens_hsa005310.95574194
82RNA transport_Homo sapiens_hsa030130.93921375
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93159367
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91662246
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91157168
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89483635
87Tryptophan metabolism_Homo sapiens_hsa003800.89414179
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88855464
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.88094446
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87638397
91Cell cycle_Homo sapiens_hsa041100.87217857
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87117680
93One carbon pool by folate_Homo sapiens_hsa006700.84704441
94Acute myeloid leukemia_Homo sapiens_hsa052210.83855196
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83381076
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82929346
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78018709
98p53 signaling pathway_Homo sapiens_hsa041150.76860521
99Regulation of autophagy_Homo sapiens_hsa041400.73608619
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72604000
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72377666
102Ribosome_Homo sapiens_hsa030100.71439391
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.71435138
104Epstein-Barr virus infection_Homo sapiens_hsa051690.71078498
105Prolactin signaling pathway_Homo sapiens_hsa049170.70760003
106TGF-beta signaling pathway_Homo sapiens_hsa043500.70361705
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.69968188
108Nucleotide excision repair_Homo sapiens_hsa034200.67330051
109Platelet activation_Homo sapiens_hsa046110.65608078
110Long-term potentiation_Homo sapiens_hsa047200.65261225
111Olfactory transduction_Homo sapiens_hsa047400.65033352
112Chronic myeloid leukemia_Homo sapiens_hsa052200.64740743
113Peroxisome_Homo sapiens_hsa041460.64213672
114Collecting duct acid secretion_Homo sapiens_hsa049660.63897716
115Nicotine addiction_Homo sapiens_hsa050330.63679451
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.63279861
117beta-Alanine metabolism_Homo sapiens_hsa004100.62735561
118Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61770204
119Hepatitis C_Homo sapiens_hsa051600.60620808
120Purine metabolism_Homo sapiens_hsa002300.59970880
121Oocyte meiosis_Homo sapiens_hsa041140.59844995
122DNA replication_Homo sapiens_hsa030300.58436857
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57464189
124Colorectal cancer_Homo sapiens_hsa052100.57264259
125Mineral absorption_Homo sapiens_hsa049780.56646222
126Serotonergic synapse_Homo sapiens_hsa047260.56056715
127Long-term depression_Homo sapiens_hsa047300.55675835
128Ether lipid metabolism_Homo sapiens_hsa005650.54197751
129VEGF signaling pathway_Homo sapiens_hsa043700.54003820
130Chemical carcinogenesis_Homo sapiens_hsa052040.53452701
131Thyroid cancer_Homo sapiens_hsa052160.53396452
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53112490
133Amoebiasis_Homo sapiens_hsa051460.52963959
134Metabolic pathways_Homo sapiens_hsa011000.52857782
135Morphine addiction_Homo sapiens_hsa050320.52434366
136Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52245200
137Pancreatic cancer_Homo sapiens_hsa052120.52181963
138Sphingolipid metabolism_Homo sapiens_hsa006000.51615358
139Proteasome_Homo sapiens_hsa030500.50858152
140Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50720116
141Tyrosine metabolism_Homo sapiens_hsa003500.50318183
142Glioma_Homo sapiens_hsa052140.50241971
143N-Glycan biosynthesis_Homo sapiens_hsa005100.50218992
144Synaptic vesicle cycle_Homo sapiens_hsa047210.50058041
145MicroRNAs in cancer_Homo sapiens_hsa052060.49987866
146Hippo signaling pathway_Homo sapiens_hsa043900.49913545
147Tight junction_Homo sapiens_hsa045300.49568059
148Linoleic acid metabolism_Homo sapiens_hsa005910.49404499
149HTLV-I infection_Homo sapiens_hsa051660.48662531
150Small cell lung cancer_Homo sapiens_hsa052220.48541053
151Cholinergic synapse_Homo sapiens_hsa047250.46909133
152Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45531010
153MAPK signaling pathway_Homo sapiens_hsa040100.45032377
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44077516
155HIF-1 signaling pathway_Homo sapiens_hsa040660.43612320
156Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43545268
157Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43535462
158Melanoma_Homo sapiens_hsa052180.43141464
159Maturity onset diabetes of the young_Homo sapiens_hsa049500.42872668
160Dorso-ventral axis formation_Homo sapiens_hsa043200.42076907
161Renin secretion_Homo sapiens_hsa049240.41768669
162Huntingtons disease_Homo sapiens_hsa050160.41514376
163Circadian entrainment_Homo sapiens_hsa047130.41062554
164Arginine and proline metabolism_Homo sapiens_hsa003300.40227370
165Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39682017
166Folate biosynthesis_Homo sapiens_hsa007900.39118806
167Retinol metabolism_Homo sapiens_hsa008300.38295521
168Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37263017
169Alzheimers disease_Homo sapiens_hsa050100.36563067
170Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36393514
171Complement and coagulation cascades_Homo sapiens_hsa046100.35919323
172Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31825175
173Pyruvate metabolism_Homo sapiens_hsa006200.31196140
174Vitamin B6 metabolism_Homo sapiens_hsa007500.31109520
175Pyrimidine metabolism_Homo sapiens_hsa002400.30899890
176Prostate cancer_Homo sapiens_hsa052150.29579185
177Steroid hormone biosynthesis_Homo sapiens_hsa001400.28425941

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