RAP1GDS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The smg GDP dissociation stimulator (smgGDS) protein is a stimulatory GDP/GTP exchange protein with GTPase activity (Riess et al., 1993 [PubMed 8262526]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.09428538
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.55534490
3synaptic vesicle exocytosis (GO:0016079)5.53008771
4glutamate secretion (GO:0014047)5.48401416
5locomotory exploration behavior (GO:0035641)5.27174308
6regulation of synaptic vesicle exocytosis (GO:2000300)5.14208277
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.01125103
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.90398979
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.86906504
10neuronal action potential propagation (GO:0019227)4.66404307
11vocalization behavior (GO:0071625)4.57556975
12regulation of synaptic vesicle transport (GO:1902803)4.50833635
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.49221978
14neurotransmitter secretion (GO:0007269)4.26541089
15neuron cell-cell adhesion (GO:0007158)4.20100929
16regulation of glutamate receptor signaling pathway (GO:1900449)4.18562099
17protein localization to synapse (GO:0035418)4.10127602
18regulation of neuronal synaptic plasticity (GO:0048168)4.06442814
19regulation of synapse structural plasticity (GO:0051823)4.03814665
20presynaptic membrane organization (GO:0097090)3.98780405
21exploration behavior (GO:0035640)3.96505618
22regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93129624
23ionotropic glutamate receptor signaling pathway (GO:0035235)3.92638974
24cellular potassium ion homeostasis (GO:0030007)3.89133080
25DNA double-strand break processing (GO:0000729)3.86916503
26layer formation in cerebral cortex (GO:0021819)3.79890087
27activation of protein kinase A activity (GO:0034199)3.70833933
28sodium ion export (GO:0071436)3.68145400
29proline transport (GO:0015824)3.66945232
30pyrimidine nucleobase catabolic process (GO:0006208)3.66445928
31gamma-aminobutyric acid transport (GO:0015812)3.61284901
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.60531873
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.60104673
34synaptic transmission, glutamatergic (GO:0035249)3.55367692
35neuron-neuron synaptic transmission (GO:0007270)3.53135937
36neurotransmitter transport (GO:0006836)3.47665007
37glutamate receptor signaling pathway (GO:0007215)3.46536373
38glycine transport (GO:0015816)3.42040743
39response to pheromone (GO:0019236)3.41394010
40neurotransmitter-gated ion channel clustering (GO:0072578)3.37068512
41regulation of synaptic plasticity (GO:0048167)3.35038451
42regulation of excitatory postsynaptic membrane potential (GO:0060079)3.34330208
43cerebellar Purkinje cell differentiation (GO:0021702)3.31938980
44vesicle transport along microtubule (GO:0047496)3.31757108
45platelet dense granule organization (GO:0060155)3.30056672
46righting reflex (GO:0060013)3.29863757
47long-term memory (GO:0007616)3.29717767
48regulation of neurotransmitter secretion (GO:0046928)3.29424525
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.28684664
50L-amino acid import (GO:0043092)3.28549881
51neuromuscular process controlling balance (GO:0050885)3.27164053
52positive regulation of protein autophosphorylation (GO:0031954)3.26571356
53long-term synaptic potentiation (GO:0060291)3.26430565
54dendritic spine morphogenesis (GO:0060997)3.25219710
55positive regulation of membrane potential (GO:0045838)3.24774094
56regulation of neurotransmitter levels (GO:0001505)3.22711969
57synaptic vesicle endocytosis (GO:0048488)3.21566935
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.20964160
59neuromuscular process controlling posture (GO:0050884)3.18976434
60regulation of postsynaptic membrane potential (GO:0060078)3.18627696
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14124390
62neuron recognition (GO:0008038)3.11976414
63nucleobase catabolic process (GO:0046113)3.10297559
64cullin deneddylation (GO:0010388)3.10095471
65negative regulation of synaptic transmission, GABAergic (GO:0032229)3.09823712
66regulation of voltage-gated calcium channel activity (GO:1901385)3.09634219
67regulation of neurotransmitter transport (GO:0051588)3.07747452
68protein deneddylation (GO:0000338)3.07230330
69dendrite morphogenesis (GO:0048813)3.06754317
70keratinocyte development (GO:0003334)3.06205327
71negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06182899
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05636717
73gamma-aminobutyric acid signaling pathway (GO:0007214)3.03195093
74transmission of nerve impulse (GO:0019226)3.02894651
75membrane depolarization during action potential (GO:0086010)3.01692282
76cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.00532756
77organelle transport along microtubule (GO:0072384)2.99571230
78retinal cone cell development (GO:0046549)2.99301720
79adult walking behavior (GO:0007628)2.99102377
80response to auditory stimulus (GO:0010996)2.98982327
81regulation of synaptic transmission, glutamatergic (GO:0051966)2.98116562
82regulation of vesicle fusion (GO:0031338)2.98093731
83DNA deamination (GO:0045006)2.97839111
84mating behavior (GO:0007617)2.97491573
85postsynaptic membrane organization (GO:0001941)2.96731991
86regulation of ARF protein signal transduction (GO:0032012)2.96488189
87regulation of dendritic spine morphogenesis (GO:0061001)2.95822369
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.93922506
89axonal fasciculation (GO:0007413)2.93568597
90prepulse inhibition (GO:0060134)2.92601476
91glycosphingolipid biosynthetic process (GO:0006688)2.90628023
92membrane depolarization (GO:0051899)2.90282928
93C4-dicarboxylate transport (GO:0015740)2.89079077
94nerve growth factor signaling pathway (GO:0038180)2.87853698
95negative regulation of dendrite morphogenesis (GO:0050774)2.87658809
96membrane hyperpolarization (GO:0060081)2.87278884
97auditory behavior (GO:0031223)2.87170081
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85833987
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.85734966
100negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84882042
101potassium ion import (GO:0010107)2.84050098
102regulation of dendritic spine development (GO:0060998)2.83730825
103negative regulation of microtubule polymerization (GO:0031115)2.82445737
104positive regulation of neurotransmitter transport (GO:0051590)2.81956271
105positive regulation of synaptic transmission (GO:0050806)2.80497023
106negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80099961
107positive regulation of actin filament depolymerization (GO:0030836)2.80064096
108regulation of synaptic transmission (GO:0050804)2.80010684
109positive regulation of synapse maturation (GO:0090129)2.79876196
110neuronal ion channel clustering (GO:0045161)2.79841870
111limb bud formation (GO:0060174)2.78801934
112neuromuscular process (GO:0050905)2.78641733
113glial cell proliferation (GO:0014009)2.78619801
114synaptic transmission (GO:0007268)2.78073453
115axon cargo transport (GO:0008088)2.77170577
116proteasome assembly (GO:0043248)2.76916392
117anterograde synaptic vesicle transport (GO:0048490)2.75781562
118cell communication by electrical coupling (GO:0010644)2.75598307
119inositol phosphate catabolic process (GO:0071545)2.73549999
120innervation (GO:0060384)2.70495171
121positive regulation of neurotransmitter secretion (GO:0001956)2.68804177
122learning (GO:0007612)2.68469365
123regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68382168
124presynaptic membrane assembly (GO:0097105)2.67710623
125protein localization to cilium (GO:0061512)2.67477587
126respiratory chain complex IV assembly (GO:0008535)2.65532613
127regulation of neurotransmitter uptake (GO:0051580)2.65402612
128protein neddylation (GO:0045116)2.64755130
129positive regulation of vesicle fusion (GO:0031340)2.59545153
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58900907
131startle response (GO:0001964)2.55781062
132negative regulation of cation channel activity (GO:2001258)2.55461763
133negative regulation of dendrite development (GO:2000171)2.53929128
134intraciliary transport (GO:0042073)2.52173553
135response to amphetamine (GO:0001975)2.50362570
136protein heterotetramerization (GO:0051290)2.48672279
137regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.45704295
138cerebral cortex radially oriented cell migration (GO:0021799)2.45157674
139positive regulation of mitochondrial fission (GO:0090141)2.45126822
140negative regulation of axon guidance (GO:1902668)2.43539968
141positive regulation of amino acid transport (GO:0051957)2.42077671
142membrane assembly (GO:0071709)2.41692678
143peptidyl-cysteine modification (GO:0018198)2.39225042
144prenylation (GO:0097354)2.38347663
145protein prenylation (GO:0018342)2.38347663
146detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.37427909
147water-soluble vitamin biosynthetic process (GO:0042364)2.36676900
148negative regulation of axon extension involved in axon guidance (GO:0048843)2.36484585
149positive regulation of muscle hypertrophy (GO:0014742)2.34632073
150positive regulation of cardiac muscle hypertrophy (GO:0010613)2.34632073
151long-chain fatty acid biosynthetic process (GO:0042759)2.33054581
152response to gravity (GO:0009629)2.32795150
153negative regulation of membrane potential (GO:0045837)2.32090212
154behavioral response to ethanol (GO:0048149)2.31257391
155heart process (GO:0003015)2.29299909
156heart contraction (GO:0060047)2.29299909
157positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.28783222
158retinal ganglion cell axon guidance (GO:0031290)2.27703976
159anterograde axon cargo transport (GO:0008089)2.25850203
160regulation of glucokinase activity (GO:0033131)2.24900581
161regulation of hexokinase activity (GO:1903299)2.24900581
162regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.24826192
163regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.24826192
164cytochrome complex assembly (GO:0017004)2.22119818
165dopamine transport (GO:0015872)2.22022261
166replication fork processing (GO:0031297)2.21366937

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.08267727
2GBX2_23144817_ChIP-Seq_PC3_Human3.23537070
3POU3F2_20337985_ChIP-ChIP_501MEL_Human3.11928396
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.03578604
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99124067
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.98368472
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83455912
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66373363
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66373363
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.64872726
11DROSHA_22980978_ChIP-Seq_HELA_Human2.58968548
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.54299582
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53257067
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51616383
15IGF1R_20145208_ChIP-Seq_DFB_Human2.50787406
16REST_21632747_ChIP-Seq_MESCs_Mouse2.48790189
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43462273
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.39445073
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38924819
20SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38351763
21FUS_26573619_Chip-Seq_HEK293_Human2.22831400
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19940933
23* EWS_26573619_Chip-Seq_HEK293_Human2.16347826
24VDR_22108803_ChIP-Seq_LS180_Human2.16028794
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13728906
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.11901197
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.11403907
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.04389916
29RNF2_27304074_Chip-Seq_ESCs_Mouse2.02631490
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.00146368
31AR_21572438_ChIP-Seq_LNCaP_Human2.00076447
32PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94665383
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94075587
34EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82983733
35NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71693180
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71326387
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71005944
38EZH2_27294783_Chip-Seq_NPCs_Mouse1.70088247
39TAF15_26573619_Chip-Seq_HEK293_Human1.67557990
40* NANOG_18555785_Chip-Seq_ESCs_Mouse1.65495947
41TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.64506474
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.64402137
43SMAD_19615063_ChIP-ChIP_OVARY_Human1.62641885
44ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61446868
45SMAD4_21799915_ChIP-Seq_A2780_Human1.59876098
46* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.54253421
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.53889740
48P53_22387025_ChIP-Seq_ESCs_Mouse1.52441158
49ELK1_19687146_ChIP-ChIP_HELA_Human1.52220976
50SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50643268
51* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50076904
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.49456012
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49320638
54* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48810929
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48107754
56BCAT_22108803_ChIP-Seq_LS180_Human1.47220585
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47025974
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.40901511
59CBP_20019798_ChIP-Seq_JUKART_Human1.39549405
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39549405
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38337683
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.37747207
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37403849
64E2F1_18555785_Chip-Seq_ESCs_Mouse1.36634248
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36591799
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36425521
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.36286245
68* CMYC_18555785_Chip-Seq_ESCs_Mouse1.35859759
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35500176
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35047890
71PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.34858687
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34173224
73CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33151745
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32795274
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31861354
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.31413426
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.29204578
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29058827
79* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28848794
80NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28834718
81NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28834718
82* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.27343114
83* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27211580
84SOX2_19829295_ChIP-Seq_ESCs_Human1.27109887
85NANOG_19829295_ChIP-Seq_ESCs_Human1.27109887
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26735163
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26185557
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25345386
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.25235646
90P300_19829295_ChIP-Seq_ESCs_Human1.24710397
91* P300_18555785_Chip-Seq_ESCs_Mouse1.24578416
92KDM2B_26808549_Chip-Seq_K562_Human1.24547391
93TCF4_22108803_ChIP-Seq_LS180_Human1.24184591
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23492528
95STAT3_23295773_ChIP-Seq_U87_Human1.22184856
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.21685749
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21161811
98* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19831510
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.19779365
100JUN_21703547_ChIP-Seq_K562_Human1.19568843
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19332888
102AR_19668381_ChIP-Seq_PC3_Human1.18794422
103* SOX2_18555785_Chip-Seq_ESCs_Mouse1.17257916
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.16780593
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.16520465
106AR_25329375_ChIP-Seq_VCAP_Human1.16209321
107RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13921306
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13819586
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13681029
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.13329556
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12679195
112AHR_22903824_ChIP-Seq_MCF-7_Human1.12431807
113OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12333175
114ZNF274_21170338_ChIP-Seq_K562_Hela1.12174549
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12100761
116TP53_22573176_ChIP-Seq_HFKS_Human1.10755369
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10513306
118ARNT_22903824_ChIP-Seq_MCF-7_Human1.10047965
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.09219728
120MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09053589
121EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08698741
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08679437
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08521373
124P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08073189
125TAL1_26923725_Chip-Seq_HPCs_Mouse1.07320776
126* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06905824
127TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06852248
128NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06835251
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05866224
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05154597
131CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05098719
132WT1_19549856_ChIP-ChIP_CCG9911_Human1.05041519
133* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04616062
134EST1_17652178_ChIP-ChIP_JURKAT_Human1.04295506
135TCF4_23295773_ChIP-Seq_U87_Human1.03558969
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.02845419
137PIAS1_25552417_ChIP-Seq_VCAP_Human1.02761729
138TP53_16413492_ChIP-PET_HCT116_Human1.00719854
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00169617
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99575884
141RXR_22108803_ChIP-Seq_LS180_Human0.98958529
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98597699
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.97391802
144ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97275921
145RING1B_27294783_Chip-Seq_NPCs_Mouse0.96134856
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95722397
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.95427996
148TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92110976
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.91455979
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.89790664
151* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89567170
152TET1_21490601_ChIP-Seq_MESCs_Mouse0.86202181
153NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86095639
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.85659043
155KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85509353
156SMAD4_21741376_ChIP-Seq_EPCs_Human0.85398202
157* RUNX2_22187159_ChIP-Seq_PCA_Human0.83315099
158CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83210499
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.82709471
160GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82481445
161ER_23166858_ChIP-Seq_MCF-7_Human0.82228813
162TP53_18474530_ChIP-ChIP_U2OS_Human0.80127704

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.36291796
2MP0003880_abnormal_central_pattern4.91385137
3MP0003635_abnormal_synaptic_transmissio4.07385660
4MP0004270_analgesia3.93468687
5MP0001968_abnormal_touch/_nociception3.37970210
6MP0002064_seizures3.29842857
7MP0009745_abnormal_behavioral_response3.28113234
8MP0002063_abnormal_learning/memory/cond3.16739006
9MP0009046_muscle_twitch3.16661171
10MP0002734_abnormal_mechanical_nocicepti2.87976597
11MP0002102_abnormal_ear_morphology2.83664336
12MP0002272_abnormal_nervous_system2.74780693
13MP0002736_abnormal_nociception_after2.68415086
14MP0002735_abnormal_chemical_nociception2.68303212
15MP0002572_abnormal_emotion/affect_behav2.61898047
16MP0008877_abnormal_DNA_methylation2.56018281
17MP0001486_abnormal_startle_reflex2.54408033
18MP0005423_abnormal_somatic_nervous2.53026392
19MP0002822_catalepsy2.44895482
20MP0003329_amyloid_beta_deposits2.36427015
21MP0002733_abnormal_thermal_nociception2.29859111
22MP0001970_abnormal_pain_threshold2.22610858
23MP0001501_abnormal_sleep_pattern2.17987968
24MP0004858_abnormal_nervous_system2.14984595
25MP0008569_lethality_at_weaning2.04656854
26MP0002067_abnormal_sensory_capabilities2.04287459
27MP0006072_abnormal_retinal_apoptosis2.00761608
28MP0006054_spinal_hemorrhage1.97598832
29MP0001440_abnormal_grooming_behavior1.97131231
30MP0001984_abnormal_olfaction1.94563121
31MP0004811_abnormal_neuron_physiology1.89199088
32MP0002234_abnormal_pharynx_morphology1.85511006
33MP0002837_dystrophic_cardiac_calcinosis1.78265376
34MP0002184_abnormal_innervation1.73370286
35MP0009780_abnormal_chondrocyte_physiolo1.73217967
36MP0000920_abnormal_myelination1.72736463
37MP0004924_abnormal_behavior1.72627303
38MP0005386_behavior/neurological_phenoty1.72627303
39MP0003633_abnormal_nervous_system1.67462754
40MP0000778_abnormal_nervous_system1.66838013
41MP0000955_abnormal_spinal_cord1.59893899
42MP0002557_abnormal_social/conspecific_i1.57714631
43MP0000427_abnormal_hair_cycle1.57503168
44MP0006276_abnormal_autonomic_nervous1.56570427
45MP0002909_abnormal_adrenal_gland1.54519734
46MP0005253_abnormal_eye_physiology1.51185177
47MP0002751_abnormal_autonomic_nervous1.49195812
48MP0003690_abnormal_glial_cell1.48931111
49MP0004147_increased_porphyrin_level1.48419167
50MP0002066_abnormal_motor_capabilities/c1.45921467
51MP0002882_abnormal_neuron_morphology1.45200744
52MP0000372_irregular_coat_pigmentation1.43532505
53MP0001905_abnormal_dopamine_level1.42843048
54MP0003631_nervous_system_phenotype1.41179127
55MP0004885_abnormal_endolymph1.37799800
56MP0000516_abnormal_urinary_system1.36769940
57MP0005367_renal/urinary_system_phenotyp1.36769940
58MP0003121_genomic_imprinting1.35574966
59MP0004142_abnormal_muscle_tone1.34526991
60MP0000604_amyloidosis1.32537430
61MP0005174_abnormal_tail_pigmentation1.32042193
62MP0005646_abnormal_pituitary_gland1.27417745
63MP0003634_abnormal_glial_cell1.26627031
64MP0008058_abnormal_DNA_repair1.25962162
65MP0001529_abnormal_vocalization1.25405183
66MP0003879_abnormal_hair_cell1.24342167
67MP0000569_abnormal_digit_pigmentation1.19363620
68MP0002229_neurodegeneration1.19058573
69MP0009697_abnormal_copulation1.17410632
70MP0003195_calcinosis1.14283922
71MP0003787_abnormal_imprinting1.13234713
72MP0003075_altered_response_to1.12136828
73MP0004742_abnormal_vestibular_system1.10792070
74MP0008874_decreased_physiological_sensi1.07674225
75MP0000015_abnormal_ear_pigmentation1.06960350
76MP0003632_abnormal_nervous_system1.05001237
77MP0000647_abnormal_sebaceous_gland1.04887494
78MP0000751_myopathy1.04509826
79MP0004145_abnormal_muscle_electrophysio1.03885418
80MP0003172_abnormal_lysosome_physiology1.02516526
81MP0005623_abnormal_meninges_morphology1.02152910
82MP0002152_abnormal_brain_morphology1.00243811
83MP0003122_maternal_imprinting1.00020076
84MP0001502_abnormal_circadian_rhythm0.98222190
85MP0005084_abnormal_gallbladder_morpholo0.97251248
86MP0008872_abnormal_physiological_respon0.93935721
87MP0000639_abnormal_adrenal_gland0.93573989
88MP0005187_abnormal_penis_morphology0.92632503
89MP0000631_abnormal_neuroendocrine_gland0.91002642
90MP0002938_white_spotting0.90357788
91MP0002160_abnormal_reproductive_system0.88637600
92MP0002090_abnormal_vision0.88409344
93MP0000013_abnormal_adipose_tissue0.87213558
94MP0004510_myositis0.87195987
95MP0003786_premature_aging0.87192682
96MP0001177_atelectasis0.86137774
97MP0005645_abnormal_hypothalamus_physiol0.83251148
98MP0010678_abnormal_skin_adnexa0.82347526
99MP0001299_abnormal_eye_distance/0.81456215
100MP0003137_abnormal_impulse_conducting0.81382751
101MP0000747_muscle_weakness0.80321346
102MP0005535_abnormal_body_temperature0.79122488
103MP0002069_abnormal_eating/drinking_beha0.78741207
104MP0005167_abnormal_blood-brain_barrier0.78369490
105MP0005551_abnormal_eye_electrophysiolog0.76605925
106MP0006035_abnormal_mitochondrial_morpho0.76345946
107MP0008789_abnormal_olfactory_epithelium0.75117231
108MP0008961_abnormal_basal_metabolism0.74893618
109MP0001986_abnormal_taste_sensitivity0.73837002
110MP0004484_altered_response_of0.73318149
111MP0004134_abnormal_chest_morphology0.72779401
112MP0002177_abnormal_outer_ear0.72438362
113MP0001963_abnormal_hearing_physiology0.72339441
114MP0002752_abnormal_somatic_nervous0.71788937
115MP0005195_abnormal_posterior_eye0.70906211
116MP0002638_abnormal_pupillary_reflex0.70754759
117MP0004085_abnormal_heartbeat0.69670649
118MP0005248_abnormal_Harderian_gland0.68029317
119MP0003950_abnormal_plasma_membrane0.67565426
120MP0001542_abnormal_bone_strength0.67171982
121MP0004130_abnormal_muscle_cell0.65060810
122MP0003183_abnormal_peptide_metabolism0.64291135
123MP0001485_abnormal_pinna_reflex0.62666795
124MP0003045_fibrosis0.61055270
125MP0005409_darkened_coat_color0.59600906
126MP0005171_absent_coat_pigmentation0.58770063
127MP0001664_abnormal_digestion0.57301149
128MP0005166_decreased_susceptibility_to0.57215915
129MP0001348_abnormal_lacrimal_gland0.55287672
130MP0003303_peritoneal_inflammation0.55038721
131MP0004233_abnormal_muscle_weight0.55017826
132MP0001943_abnormal_respiration0.54899532
133MP0005499_abnormal_olfactory_system0.54363788
134MP0005394_taste/olfaction_phenotype0.54363788
135MP0010234_abnormal_vibrissa_follicle0.51746748
136MP0010386_abnormal_urinary_bladder0.50843415
137MP0010769_abnormal_survival0.48404042
138MP0004215_abnormal_myocardial_fiber0.47931311
139MP0001188_hyperpigmentation0.47623607

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.77035992
2Focal motor seizures (HP:0011153)6.69042213
3Focal seizures (HP:0007359)5.33814289
4Visual hallucinations (HP:0002367)4.79663060
5Atonic seizures (HP:0010819)4.52318010
6Supranuclear gaze palsy (HP:0000605)4.32227825
7Action tremor (HP:0002345)4.31868665
8Epileptic encephalopathy (HP:0200134)4.24694715
9Progressive cerebellar ataxia (HP:0002073)3.96226279
10Ankle clonus (HP:0011448)3.92756463
11Febrile seizures (HP:0002373)3.90455096
12Termporal pattern (HP:0011008)3.74774060
13Insidious onset (HP:0003587)3.74774060
14Absence seizures (HP:0002121)3.69936809
15Generalized tonic-clonic seizures (HP:0002069)3.54150704
16Dialeptic seizures (HP:0011146)3.46335895
17Mutism (HP:0002300)3.27396892
18Pheochromocytoma (HP:0002666)3.22773280
19Depression (HP:0000716)3.21332808
20Urinary urgency (HP:0000012)3.18345496
21Dysmetria (HP:0001310)3.17657498
22Neurofibrillary tangles (HP:0002185)3.17166460
23Impaired vibration sensation in the lower limbs (HP:0002166)3.15808183
24Urinary bladder sphincter dysfunction (HP:0002839)3.14044523
25Papilledema (HP:0001085)3.05669617
26Cerebral inclusion bodies (HP:0100314)3.04735448
27Spastic gait (HP:0002064)3.02948911
28Truncal ataxia (HP:0002078)3.02655591
29Postural instability (HP:0002172)2.99199741
30Broad-based gait (HP:0002136)2.98691104
31Poor eye contact (HP:0000817)2.89369265
32Limb dystonia (HP:0002451)2.87848797
33Abnormal eating behavior (HP:0100738)2.87778676
34Scanning speech (HP:0002168)2.87217470
35Abnormality of the corticospinal tract (HP:0002492)2.86681757
36Gaze-evoked nystagmus (HP:0000640)2.86609139
37Neuroendocrine neoplasm (HP:0100634)2.80972585
38Dysdiadochokinesis (HP:0002075)2.75968763
39Anxiety (HP:0000739)2.74105388
40Pancreatic cysts (HP:0001737)2.70979646
41Methylmalonic acidemia (HP:0002912)2.70521194
42Intention tremor (HP:0002080)2.69935107
43Pancreatic fibrosis (HP:0100732)2.69550140
44Abnormal social behavior (HP:0012433)2.67805071
45Impaired social interactions (HP:0000735)2.67805071
46Delayed gross motor development (HP:0002194)2.67522071
47Torticollis (HP:0000473)2.67491615
48Progressive inability to walk (HP:0002505)2.66685474
49Volvulus (HP:0002580)2.66527541
50Hypothermia (HP:0002045)2.66414582
51Medial flaring of the eyebrow (HP:0010747)2.64349717
52True hermaphroditism (HP:0010459)2.63139654
53Intestinal atresia (HP:0011100)2.55725718
54Diplopia (HP:0000651)2.55292725
55Abnormality of binocular vision (HP:0011514)2.55292725
56Abnormality of midbrain morphology (HP:0002418)2.55244296
57Molar tooth sign on MRI (HP:0002419)2.55244296
58Amyotrophic lateral sclerosis (HP:0007354)2.51892433
59Peripheral hypomyelination (HP:0007182)2.49912210
60Progressive macrocephaly (HP:0004481)2.46934227
61Lower limb muscle weakness (HP:0007340)2.45656999
62Hyperventilation (HP:0002883)2.42513858
63Amblyopia (HP:0000646)2.41847478
64Degeneration of the lateral corticospinal tracts (HP:0002314)2.39003204
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.39003204
66Focal dystonia (HP:0004373)2.38263327
67Abnormality of the lower motor neuron (HP:0002366)2.35955371
68Gait imbalance (HP:0002141)2.33500354
69Megalencephaly (HP:0001355)2.32789143
70Impaired smooth pursuit (HP:0007772)2.32750726
71Bradykinesia (HP:0002067)2.32467612
72Nephronophthisis (HP:0000090)2.28475188
73Genetic anticipation (HP:0003743)2.28037499
74Neuronal loss in central nervous system (HP:0002529)2.27215334
75Hemiplegia (HP:0002301)2.27155755
76Onion bulb formation (HP:0003383)2.25065321
77Fetal akinesia sequence (HP:0001989)2.23892636
78Drooling (HP:0002307)2.23073584
79Excessive salivation (HP:0003781)2.23073584
80Aplasia/Hypoplasia of the tibia (HP:0005772)2.21676700
81Stereotypic behavior (HP:0000733)2.21513486
82Craniofacial dystonia (HP:0012179)2.20175917
83Ulnar claw (HP:0001178)2.20015887
84Rapidly progressive (HP:0003678)2.17634486
85Acute necrotizing encephalopathy (HP:0006965)2.16762410
86Annular pancreas (HP:0001734)2.15110407
87Thyroiditis (HP:0100646)2.15102883
88Ventricular fibrillation (HP:0001663)2.14479982
89Amniotic constriction ring (HP:0009775)2.13186032
90Abnormality of placental membranes (HP:0011409)2.13186032
91Neoplasm of the peripheral nervous system (HP:0100007)2.11998973
92Short tibia (HP:0005736)2.11317379
93Hammertoe (HP:0001765)2.10900719
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.10048162
95Dysmetric saccades (HP:0000641)2.09827200
96Rigidity (HP:0002063)2.08873668
97Insomnia (HP:0100785)2.07915004
98Atrophy/Degeneration involving motor neurons (HP:0007373)2.07362027
99Congenital primary aphakia (HP:0007707)2.05958836
100Clonus (HP:0002169)2.04767560
101Impaired vibratory sensation (HP:0002495)2.04435211
102Adrenal hypoplasia (HP:0000835)2.03266749
103Abnormality of ocular smooth pursuit (HP:0000617)2.03030972
104Fair hair (HP:0002286)2.02926749
105Akinesia (HP:0002304)2.00739191
106Type 2 muscle fiber atrophy (HP:0003554)1.99378057
107Abnormality of the renal medulla (HP:0100957)1.99304205
108Resting tremor (HP:0002322)1.98751109
109Abnormality of saccadic eye movements (HP:0000570)1.97808368
110Inappropriate behavior (HP:0000719)1.96587066
111Gait ataxia (HP:0002066)1.96428142
112Absent speech (HP:0001344)1.96379869
113Abnormality of the labia minora (HP:0012880)1.96164760
114Abnormality of the renal cortex (HP:0011035)1.94833125
115Genital tract atresia (HP:0001827)1.93818473
116Pointed chin (HP:0000307)1.93519479
117Generalized myoclonic seizures (HP:0002123)1.93345492
118Epileptiform EEG discharges (HP:0011182)1.92919423
119Hypoproteinemia (HP:0003075)1.92726643
120Hemiparesis (HP:0001269)1.92268504
121Lower limb amyotrophy (HP:0007210)1.91950875
122Apathy (HP:0000741)1.90904274
123Astrocytoma (HP:0009592)1.90624662
124Abnormality of the astrocytes (HP:0100707)1.90624662
125Acute encephalopathy (HP:0006846)1.90050018
126Hypsarrhythmia (HP:0002521)1.88331479
127Incomplete penetrance (HP:0003829)1.88165187
128Pachygyria (HP:0001302)1.87309425
129Postural tremor (HP:0002174)1.86459369
130Delusions (HP:0000746)1.86267286
131Poor suck (HP:0002033)1.85833106
132Blue irides (HP:0000635)1.85723721
133Muscular hypotonia of the trunk (HP:0008936)1.85715094
134Nephrogenic diabetes insipidus (HP:0009806)1.85429311
135Agitation (HP:0000713)1.85309252
136EEG with generalized epileptiform discharges (HP:0011198)1.84897578
137Methylmalonic aciduria (HP:0012120)1.84588786
138Tongue fasciculations (HP:0001308)1.84214464
139Oligodactyly (hands) (HP:0001180)1.84053057
140Psychosis (HP:0000709)1.84035956
141Increased CSF lactate (HP:0002490)1.83736659
142Renal cortical cysts (HP:0000803)1.83640073
143Retinal dysplasia (HP:0007973)1.83309311
144Hypoventilation (HP:0002791)1.82383920
145Inability to walk (HP:0002540)1.82243929
146Mitochondrial inheritance (HP:0001427)1.81989077
147Congenital stationary night blindness (HP:0007642)1.81579363
148Dyskinesia (HP:0100660)1.81343574
149Lower limb asymmetry (HP:0100559)1.81121363
150Lissencephaly (HP:0001339)1.80589971
151Postaxial hand polydactyly (HP:0001162)1.80323450
152Abnormality of the metopic suture (HP:0005556)1.78960726
153Polyphagia (HP:0002591)1.77906379
154Supernumerary spleens (HP:0009799)1.76766750
155Optic nerve hypoplasia (HP:0000609)1.76626803
156Small hand (HP:0200055)1.74198549
157Metaphyseal dysplasia (HP:0100255)1.74054543
158Abolished electroretinogram (ERG) (HP:0000550)1.73240284
159Abnormality of the fovea (HP:0000493)1.72950411
160Popliteal pterygium (HP:0009756)1.71055646
161Vaginal atresia (HP:0000148)1.70828411
162Neoplasm of the adrenal cortex (HP:0100641)1.68378867
163Degeneration of anterior horn cells (HP:0002398)1.68042993
164Abnormality of the anterior horn cell (HP:0006802)1.68042993
165Abnormal mitochondria in muscle tissue (HP:0008316)1.67903985
166Hyperinsulinemic hypoglycemia (HP:0000825)1.67054013
167Hypoplasia of the fovea (HP:0007750)1.65824464
168Aplasia/Hypoplasia of the fovea (HP:0008060)1.65824464
169Abnormality of macular pigmentation (HP:0008002)1.65673585
170Hepatocellular necrosis (HP:0001404)1.65248683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.87984826
2NTRK33.71553447
3TRIM283.67121346
4FRK3.40900745
5EPHA43.36939730
6MAP3K42.98280316
7MINK12.83187602
8ERBB32.66922484
9WNK32.50356740
10KSR22.49784460
11PAK62.40221872
12BCR2.38273802
13MAP2K72.36909242
14MARK12.34899548
15DAPK22.32480262
16NTRK12.29871235
17MAP4K22.27712461
18MAP3K122.26837777
19EIF2AK32.18182528
20BMPR1B2.17321495
21NUAK12.09959366
22RIPK42.04466085
23MAP2K42.03252274
24CAMKK11.93228468
25PRKD31.76304864
26CDK191.74775231
27MKNK21.71158941
28EIF2AK11.61436553
29CASK1.61367887
30NEK11.59196132
31NTRK21.59054893
32CDK51.53926058
33CSNK1G31.50862192
34PLK21.50669266
35MST41.50492730
36SIK31.48655782
37BUB11.47209089
38GRK51.41345137
39MAP3K131.40087700
40MAP3K21.37391771
41CSNK1G11.36829351
42TYRO31.34786407
43ARAF1.33707496
44RET1.31277099
45ACVR1B1.30148183
46KSR11.27874468
47PLK31.27825859
48FES1.27488972
49OXSR11.26409853
50CSNK1A1L1.25285192
51PRPF4B1.22896947
52CAMKK21.22554373
53LMTK21.22132270
54DAPK11.20532600
55ZAK1.17636149
56SGK4941.16825357
57SGK2231.16825357
58UHMK11.16481020
59GRK11.14656547
60SIK21.14589864
61STK391.09273084
62STK381.06957308
63PHKG11.06565090
64PHKG21.06565090
65LATS21.06366100
66MKNK11.05836914
67WNK11.04879573
68PRKCH1.04718966
69MAPK131.04566580
70MAPKAPK51.03873818
71PRKCG1.02330799
72CDK141.00739947
73CDK180.99194294
74CDK150.98103407
75TAOK10.92395212
76TNIK0.90424727
77LIMK10.90327002
78PDK10.88127556
79PNCK0.87602332
80CAMK2A0.87360188
81ALK0.86275095
82ADRBK20.85174052
83PLK40.85008234
84CDK11A0.83353398
85PAK30.83116550
86STK110.82824772
87PTK2B0.82228817
88MUSK0.81318224
89CAMK2B0.80453779
90PDPK10.80365274
91CSNK1G20.79202329
92SCYL20.74438111
93MAP3K10.71856334
94CAMK10.70599668
95SGK30.70374732
96TNK20.69259717
97BCKDK0.66698903
98RAF10.65722408
99ROCK20.65360693
100WEE10.63551998
101SGK20.61736094
102EIF2AK20.61020685
103CAMK1G0.60628851
104MARK20.59882123
105BRSK20.59813065
106TGFBR10.58134404
107RIPK10.58055806
108FYN0.57955171
109MYLK0.57269333
110ROCK10.56006372
111PINK10.55119105
112CAMK2G0.54618420
113STK160.54307297
114FGR0.54214231
115ADRBK10.54111885
116SGK10.53958331
117CAMK2D0.53791500
118BMPR20.53109580
119MAP3K70.51809609
120FLT30.51562687
121TAF10.50204513
122INSRR0.49322317
123DYRK20.49041105
124MAP2K10.48090786
125PKN10.44732919
126PRKCE0.44244799
127CDK80.44077401
128MAPK100.43147008
129DMPK0.42389887
130PRKCZ0.42243513
131FER0.41953003
132DAPK30.41722589
133VRK10.41573797
134TESK10.41308308
135FGFR20.40627839
136PLK10.40138830
137RPS6KA30.39743405
138SRPK10.39425973
139DYRK1A0.37925920
140BRSK10.36204907
141TIE10.35786924
142WNK40.35564177
143PRKG10.33647010
144PRKCQ0.33581665
145NEK60.32598521
146PRKCI0.32495639
147MAPK120.31710140
148CCNB10.31579440
149AKT30.30593628
150CSNK1A10.26164606
151CSNK1D0.26023970
152GRK70.25765306

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.63983292
2Synaptic vesicle cycle_Homo sapiens_hsa047213.37356871
3Olfactory transduction_Homo sapiens_hsa047402.92474939
4Nicotine addiction_Homo sapiens_hsa050332.81445880
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.77486987
6Long-term potentiation_Homo sapiens_hsa047202.35768065
7Circadian entrainment_Homo sapiens_hsa047132.35345915
8GABAergic synapse_Homo sapiens_hsa047272.34080417
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.31167892
10Proteasome_Homo sapiens_hsa030502.25124398
11Glutamatergic synapse_Homo sapiens_hsa047242.24850690
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.24153635
13Morphine addiction_Homo sapiens_hsa050322.19736154
14Amphetamine addiction_Homo sapiens_hsa050312.06049111
15Dopaminergic synapse_Homo sapiens_hsa047282.03527767
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.98563311
17Salivary secretion_Homo sapiens_hsa049701.98407864
18Propanoate metabolism_Homo sapiens_hsa006401.96829763
19Non-homologous end-joining_Homo sapiens_hsa034501.89455274
20Gastric acid secretion_Homo sapiens_hsa049711.86910719
21Butanoate metabolism_Homo sapiens_hsa006501.84244316
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84041402
23Cholinergic synapse_Homo sapiens_hsa047251.82776938
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.76609066
25Fatty acid elongation_Homo sapiens_hsa000621.75570702
26Regulation of autophagy_Homo sapiens_hsa041401.75484416
27Basal transcription factors_Homo sapiens_hsa030221.72234115
28Insulin secretion_Homo sapiens_hsa049111.70728702
29Steroid biosynthesis_Homo sapiens_hsa001001.62092477
30Oxidative phosphorylation_Homo sapiens_hsa001901.59239169
31Long-term depression_Homo sapiens_hsa047301.58941476
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.58884271
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58574058
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58467277
35Vitamin B6 metabolism_Homo sapiens_hsa007501.56962647
36Renin secretion_Homo sapiens_hsa049241.53490358
37Collecting duct acid secretion_Homo sapiens_hsa049661.51916225
38Oxytocin signaling pathway_Homo sapiens_hsa049211.51118020
39GnRH signaling pathway_Homo sapiens_hsa049121.44404096
40Serotonergic synapse_Homo sapiens_hsa047261.42374150
41Cocaine addiction_Homo sapiens_hsa050301.40371785
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40212117
43Taste transduction_Homo sapiens_hsa047421.38695518
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.38564028
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.37830488
46Calcium signaling pathway_Homo sapiens_hsa040201.31275817
47Gap junction_Homo sapiens_hsa045401.30155855
48Parkinsons disease_Homo sapiens_hsa050121.28978317
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23070729
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22970186
51Glioma_Homo sapiens_hsa052141.19329192
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18314021
53Nitrogen metabolism_Homo sapiens_hsa009101.17925326
54Fanconi anemia pathway_Homo sapiens_hsa034601.16267217
55Estrogen signaling pathway_Homo sapiens_hsa049151.14908617
56cAMP signaling pathway_Homo sapiens_hsa040241.14523638
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13946261
58Vibrio cholerae infection_Homo sapiens_hsa051101.09488898
59RNA degradation_Homo sapiens_hsa030181.08747992
60Axon guidance_Homo sapiens_hsa043601.08427038
61ErbB signaling pathway_Homo sapiens_hsa040121.07655538
62Type II diabetes mellitus_Homo sapiens_hsa049301.05440863
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01736389
64Sulfur metabolism_Homo sapiens_hsa009200.99823197
65Dorso-ventral axis formation_Homo sapiens_hsa043200.99791017
66Alzheimers disease_Homo sapiens_hsa050100.98487758
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98266342
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.93276554
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90611210
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.88709137
71Melanogenesis_Homo sapiens_hsa049160.88669394
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.86897135
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84635400
74Endocytosis_Homo sapiens_hsa041440.82471666
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81398682
76Peroxisome_Homo sapiens_hsa041460.80989567
77VEGF signaling pathway_Homo sapiens_hsa043700.80197543
78Selenocompound metabolism_Homo sapiens_hsa004500.80102437
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79155370
80Homologous recombination_Homo sapiens_hsa034400.77847772
81Pancreatic secretion_Homo sapiens_hsa049720.77412609
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.77374180
83Oocyte meiosis_Homo sapiens_hsa041140.76494442
84Phototransduction_Homo sapiens_hsa047440.76062484
85MAPK signaling pathway_Homo sapiens_hsa040100.76034033
86Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74438510
87Choline metabolism in cancer_Homo sapiens_hsa052310.72268297
88Thyroid hormone synthesis_Homo sapiens_hsa049180.71646949
89RNA polymerase_Homo sapiens_hsa030200.71599586
90Dilated cardiomyopathy_Homo sapiens_hsa054140.70400609
91Cardiac muscle contraction_Homo sapiens_hsa042600.68507298
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.67742882
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.67505749
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66791576
95Fatty acid metabolism_Homo sapiens_hsa012120.66211529
96Renal cell carcinoma_Homo sapiens_hsa052110.65485398
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65424418
98Rap1 signaling pathway_Homo sapiens_hsa040150.65189483
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63587642
100Ras signaling pathway_Homo sapiens_hsa040140.63559235
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61730160
102Primary bile acid biosynthesis_Homo sapiens_hsa001200.61683871
103Chemokine signaling pathway_Homo sapiens_hsa040620.59997916
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58648804
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58514284
106Huntingtons disease_Homo sapiens_hsa050160.57707698
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57213295
108Hedgehog signaling pathway_Homo sapiens_hsa043400.57119254
109Ether lipid metabolism_Homo sapiens_hsa005650.57049539
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.55829558
111Inositol phosphate metabolism_Homo sapiens_hsa005620.54987982
112Nucleotide excision repair_Homo sapiens_hsa034200.53941739
113Prion diseases_Homo sapiens_hsa050200.52655029
114Pyruvate metabolism_Homo sapiens_hsa006200.51672910
115mTOR signaling pathway_Homo sapiens_hsa041500.51505111
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50728959
117Non-small cell lung cancer_Homo sapiens_hsa052230.50392575
118Purine metabolism_Homo sapiens_hsa002300.49908169
119Endometrial cancer_Homo sapiens_hsa052130.48926617
120Salmonella infection_Homo sapiens_hsa051320.48062547
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47410453
122p53 signaling pathway_Homo sapiens_hsa041150.47123658
123Caffeine metabolism_Homo sapiens_hsa002320.46410365
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45528804
125beta-Alanine metabolism_Homo sapiens_hsa004100.45429699
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45090169
127Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44980701
128Maturity onset diabetes of the young_Homo sapiens_hsa049500.44935614
129Tryptophan metabolism_Homo sapiens_hsa003800.44690344
130Platelet activation_Homo sapiens_hsa046110.44368945
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43613702
132Type I diabetes mellitus_Homo sapiens_hsa049400.43487153
133Rheumatoid arthritis_Homo sapiens_hsa053230.43478802
134Folate biosynthesis_Homo sapiens_hsa007900.43199635
135Alcoholism_Homo sapiens_hsa050340.42602452
136Hippo signaling pathway_Homo sapiens_hsa043900.42022470
137Circadian rhythm_Homo sapiens_hsa047100.41696350
138Bile secretion_Homo sapiens_hsa049760.41383715
139Insulin signaling pathway_Homo sapiens_hsa049100.41241654
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41186960
141Phagosome_Homo sapiens_hsa041450.40434391
142Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39627036
143Glucagon signaling pathway_Homo sapiens_hsa049220.38945882
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38655828
145RNA transport_Homo sapiens_hsa030130.38071778
146T cell receptor signaling pathway_Homo sapiens_hsa046600.37885586
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37819735
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36796743
149Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36444723
150Colorectal cancer_Homo sapiens_hsa052100.35128147
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34878787
152Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34711099
153African trypanosomiasis_Homo sapiens_hsa051430.33827423
154Metabolic pathways_Homo sapiens_hsa011000.33481777
155Cysteine and methionine metabolism_Homo sapiens_hsa002700.32144191
156Wnt signaling pathway_Homo sapiens_hsa043100.31684594

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