RAP1BP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.36197781
2import into cell (GO:0098657)6.81691381
3response to gravity (GO:0009629)6.55340574
4nucleobase catabolic process (GO:0046113)6.47698377
5negative regulation of JAK-STAT cascade (GO:0046426)6.23226715
6cerebral cortex radially oriented cell migration (GO:0021799)5.96169750
7positive regulation of amino acid transport (GO:0051957)5.38849625
8regulation of skeletal muscle contraction (GO:0014819)5.30153595
9ovulation cycle (GO:0042698)5.24048894
10resolution of meiotic recombination intermediates (GO:0000712)5.22521495
11protein polyglutamylation (GO:0018095)4.99060455
12water-soluble vitamin biosynthetic process (GO:0042364)4.91081016
13central nervous system projection neuron axonogenesis (GO:0021952)4.66100017
14cell migration in hindbrain (GO:0021535)4.51482408
15mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.50095826
16positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.50095826
17negative regulation of calcium ion-dependent exocytosis (GO:0045955)4.46768693
18midgut development (GO:0007494)4.41753888
19negative regulation of muscle hypertrophy (GO:0014741)4.40566286
20presynaptic membrane assembly (GO:0097105)4.28739441
21negative regulation of astrocyte differentiation (GO:0048712)4.25989797
22telencephalon development (GO:0021537)4.20824304
23replication fork processing (GO:0031297)4.13661652
24response to UV-C (GO:0010225)4.07866161
25negative regulation of activin receptor signaling pathway (GO:0032926)4.06431810
26anatomical structure arrangement (GO:0048532)4.04394358
27DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.93361669
28positive regulation of dendritic spine morphogenesis (GO:0061003)3.92656324
29positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.77264181
30regulation of glutamate secretion (GO:0014048)3.66788330
31regulation of DNA endoreduplication (GO:0032875)3.63001848
32skeletal muscle adaptation (GO:0043501)3.61767273
33muscle atrophy (GO:0014889)3.60316694
34positive regulation of cardiac muscle cell differentiation (GO:2000727)3.59607968
35striated muscle atrophy (GO:0014891)3.52791377
36N-glycan processing (GO:0006491)3.50708970
37epithelial cilium movement (GO:0003351)3.50567688
38UV protection (GO:0009650)3.49040258
39sulfation (GO:0051923)3.47821542
40central nervous system neuron axonogenesis (GO:0021955)3.47268088
41DNA damage response, signal transduction resulting in transcription (GO:0042772)3.44663072
42limb bud formation (GO:0060174)3.43742304
43cerebral cortex cell migration (GO:0021795)3.41129578
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.30656318
45positive regulation of mast cell degranulation (GO:0043306)3.30656318
46presynaptic membrane organization (GO:0097090)3.26570746
47actin-myosin filament sliding (GO:0033275)3.24256021
48muscle filament sliding (GO:0030049)3.24256021
49axonemal dynein complex assembly (GO:0070286)3.22366601
50olfactory bulb development (GO:0021772)3.21929752
51regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.21266865
52positive regulation of dendrite morphogenesis (GO:0050775)3.18724193
53dentate gyrus development (GO:0021542)3.16036095
54negative regulation of organelle assembly (GO:1902116)3.14813687
55regulation of chronic inflammatory response (GO:0002676)3.14401690
56cell proliferation in forebrain (GO:0021846)3.10692588
57positive regulation of organic acid transport (GO:0032892)3.09985865
58nerve growth factor signaling pathway (GO:0038180)3.07669775
59spinal cord development (GO:0021510)3.06950719
60modulation by virus of host process (GO:0019054)3.06847493
61Rap protein signal transduction (GO:0032486)3.05348332
62calcium ion import (GO:0070509)3.04840491
63positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.01377170
64cilium movement (GO:0003341)3.00596194
65regulation of muscle hypertrophy (GO:0014743)2.97869841
66lymphangiogenesis (GO:0001946)2.92158924
67regulation of transforming growth factor beta2 production (GO:0032909)2.89994671
68axoneme assembly (GO:0035082)2.86411092
69regulation of germinal center formation (GO:0002634)2.83174505
70forebrain cell migration (GO:0021885)2.83173595
71protein localization to Golgi apparatus (GO:0034067)2.82703946
72negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.82192004
73positive regulation of protein autophosphorylation (GO:0031954)2.80690365
74dendrite morphogenesis (GO:0048813)2.80217453
75alternative mRNA splicing, via spliceosome (GO:0000380)2.80128080
76negative regulation of systemic arterial blood pressure (GO:0003085)2.79364365
77endocytic recycling (GO:0032456)2.78145705
78arginine catabolic process (GO:0006527)2.77428428
79intra-S DNA damage checkpoint (GO:0031573)2.73759698
80layer formation in cerebral cortex (GO:0021819)2.72327346
81negative regulation of gluconeogenesis (GO:0045721)2.71247571
82cobalamin metabolic process (GO:0009235)2.71202140
83negative regulation of smooth muscle cell differentiation (GO:0051151)2.70862542
84actin-mediated cell contraction (GO:0070252)2.70661396
85skeletal muscle tissue regeneration (GO:0043403)2.70473365
86positive regulation of cardiac muscle hypertrophy (GO:0010613)2.69499737
87positive regulation of muscle hypertrophy (GO:0014742)2.69499737
88negative regulation of skeletal muscle tissue development (GO:0048642)2.68870275
89positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.67959933
90positive regulation of mast cell activation (GO:0033005)2.66294780
91positive regulation of amine transport (GO:0051954)2.66124467
92axon extension (GO:0048675)2.65965035
93cartilage morphogenesis (GO:0060536)2.65684220
94acrosome assembly (GO:0001675)2.64081762
95TOR signaling (GO:0031929)2.63010822
96DNA excision (GO:0044349)2.61013259
97nucleotide-excision repair, DNA damage removal (GO:0000718)2.61013259
98membrane assembly (GO:0071709)2.59713052
99relaxation of muscle (GO:0090075)2.59502812
100Golgi to endosome transport (GO:0006895)2.58583713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.62092326
2EZH2_22144423_ChIP-Seq_EOC_Human4.98015178
3GBX2_23144817_ChIP-Seq_PC3_Human3.75295160
4VDR_22108803_ChIP-Seq_LS180_Human3.54355064
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.33501982
6ZFP57_27257070_Chip-Seq_ESCs_Mouse3.13306354
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.73648770
8FUS_26573619_Chip-Seq_HEK293_Human2.51366943
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35115823
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.30374330
11AR_21572438_ChIP-Seq_LNCaP_Human2.16189936
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.15641164
13CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.10045604
14EED_16625203_ChIP-ChIP_MESCs_Mouse1.94861110
15P300_19829295_ChIP-Seq_ESCs_Human1.94762399
16TAF15_26573619_Chip-Seq_HEK293_Human1.93077101
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91780489
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90570550
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.89031410
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88203331
21SMAD4_21799915_ChIP-Seq_A2780_Human1.87915888
22OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82836474
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.81117484
24JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80218125
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.77862933
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.76259361
27CBP_20019798_ChIP-Seq_JUKART_Human1.75465701
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.75465701
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74406764
30EWS_26573619_Chip-Seq_HEK293_Human1.72963058
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72862584
32CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72479787
33ER_23166858_ChIP-Seq_MCF-7_Human1.63583181
34TP53_18474530_ChIP-ChIP_U2OS_Human1.62942815
35PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62694879
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62032857
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59544305
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.59529269
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55670246
40RNF2_27304074_Chip-Seq_NSC_Mouse1.54849175
41CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51900786
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51896129
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.50735177
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50735177
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48875448
46STAT3_23295773_ChIP-Seq_U87_Human1.46047524
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45765689
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36982944
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36982944
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36264361
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.31766312
52AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31252489
53P53_22387025_ChIP-Seq_ESCs_Mouse1.31063760
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30200648
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.29541792
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.29183928
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28366749
58ZNF274_21170338_ChIP-Seq_K562_Hela1.26125091
59SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25069585
60TCF4_23295773_ChIP-Seq_U87_Human1.22482712
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22220586
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21793654
63KDM2B_26808549_Chip-Seq_REH_Human1.21512598
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.16691138
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16174995
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15912329
67SOX9_26525672_Chip-Seq_HEART_Mouse1.13964963
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13643657
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.13518469
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11715459
71BCAT_22108803_ChIP-Seq_LS180_Human1.11374465
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10691603
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10529466
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10146388
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10132289
76RXR_22108803_ChIP-Seq_LS180_Human1.09318609
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08780764
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07378016
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.06146388
80NCOR_22424771_ChIP-Seq_293T_Human1.05997377
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.05344975
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.05309300
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02448393
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01956961
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00592846
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00549893
87TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99330801
88RNF2_27304074_Chip-Seq_ESCs_Mouse0.98136760
89CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98003883
90NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97676286
91JUN_21703547_ChIP-Seq_K562_Human0.97462015
92P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97343574
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97320217
94CMYC_18555785_Chip-Seq_ESCs_Mouse0.95746790
95ELK1_19687146_ChIP-ChIP_HELA_Human0.95564970
96CJUN_26792858_Chip-Seq_BT549_Human0.94747999
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.94211714
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.94096896
99BRD4_25478319_ChIP-Seq_HGPS_Human0.93674152
100TCF4_22108803_ChIP-Seq_LS180_Human0.93235493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002089_abnormal_postnatal_growth/wei3.28113064
2MP0001919_abnormal_reproductive_system3.04291726
3MP0004270_analgesia2.90415897
4MP0002160_abnormal_reproductive_system2.73062005
5MP0009250_abnormal_appendicular_skeleto2.67388551
6MP0004145_abnormal_muscle_electrophysio2.60169731
7MP0004885_abnormal_endolymph2.59856052
8MP0003806_abnormal_nucleotide_metabolis2.55860986
9MP0005389_reproductive_system_phenotype2.51105787
10MP0000569_abnormal_digit_pigmentation2.24034334
11MP0006072_abnormal_retinal_apoptosis2.19631805
12MP0000747_muscle_weakness2.05543215
13MP0004036_abnormal_muscle_relaxation2.01181259
14MP0003937_abnormal_limbs/digits/tail_de2.00053994
15MP0005386_behavior/neurological_phenoty1.90972377
16MP0004924_abnormal_behavior1.90972377
17MP0002108_abnormal_muscle_morphology1.88421080
18MP0004134_abnormal_chest_morphology1.88030946
19MP0003959_abnormal_lean_body1.79375710
20MP0002751_abnormal_autonomic_nervous1.79160872
21MP0005671_abnormal_response_to1.71689042
22MP0001968_abnormal_touch/_nociception1.71019240
23MP0005165_increased_susceptibility_to1.70686562
24MP0003724_increased_susceptibility_to1.68858306
25MP0000003_abnormal_adipose_tissue1.67904008
26MP0001542_abnormal_bone_strength1.67719537
27MP0001440_abnormal_grooming_behavior1.60711212
28MP0003950_abnormal_plasma_membrane1.57589108
29MP0002638_abnormal_pupillary_reflex1.56658425
30MP0003635_abnormal_synaptic_transmissio1.49460719
31MP0010368_abnormal_lymphatic_system1.48954920
32MP0000759_abnormal_skeletal_muscle1.45475954
33MP0001486_abnormal_startle_reflex1.45043587
34MP0005620_abnormal_muscle_contractility1.42537036
35MP0003075_altered_response_to1.41663704
36MP0003119_abnormal_digestive_system1.31161548
37MP0002734_abnormal_mechanical_nocicepti1.30854465
38MP0001905_abnormal_dopamine_level1.30565970
39MP0004084_abnormal_cardiac_muscle1.28780861
40MP0002295_abnormal_pulmonary_circulatio1.28664790
41MP0000631_abnormal_neuroendocrine_gland1.28536030
42MP0000049_abnormal_middle_ear1.25939779
43MP0010386_abnormal_urinary_bladder1.23588935
44MP0009384_cardiac_valve_regurgitation1.22162506
45MP0002735_abnormal_chemical_nociception1.19258005
46MP0001501_abnormal_sleep_pattern1.19019115
47MP0000427_abnormal_hair_cycle1.16820612
48MP0005410_abnormal_fertilization1.15682424
49MP0002067_abnormal_sensory_capabilities1.14742679
50MP0002272_abnormal_nervous_system1.14028513
51MP0009697_abnormal_copulation1.13887555
52MP0000778_abnormal_nervous_system1.13554062
53MP0001879_abnormal_lymphatic_vessel1.12810280
54MP0005367_renal/urinary_system_phenotyp1.10150752
55MP0000516_abnormal_urinary_system1.10150752
56MP0000230_abnormal_systemic_arterial1.09797451
57MP0000163_abnormal_cartilage_morphology1.07161784
58MP0002282_abnormal_trachea_morphology1.06730198
59MP0000685_abnormal_immune_system1.04963552
60MP0002184_abnormal_innervation1.04477726
61MP0000749_muscle_degeneration1.04293117
62MP0001191_abnormal_skin_condition1.02631063
63MP0001177_atelectasis1.02018642
64MP0001664_abnormal_digestion1.01174349
65MP0002896_abnormal_bone_mineralization1.00391075
66MP0009745_abnormal_behavioral_response0.96245367
67MP0002115_abnormal_skeleton_extremities0.96091218
68MP0004185_abnormal_adipocyte_glucose0.95004614
69MP0005551_abnormal_eye_electrophysiolog0.94617502
70MP0004142_abnormal_muscle_tone0.93491476
71MP0002109_abnormal_limb_morphology0.91921636
72MP0002106_abnormal_muscle_physiology0.90780813
73MP0008569_lethality_at_weaning0.89655794
74MP0002177_abnormal_outer_ear0.88573212
75MP0003283_abnormal_digestive_organ0.87702245
76MP0003705_abnormal_hypodermis_morpholog0.85098375
77MP0003633_abnormal_nervous_system0.84418607
78MP0002332_abnormal_exercise_endurance0.83382696
79MP0003631_nervous_system_phenotype0.82824848
80MP0002269_muscular_atrophy0.82808058
81MP0002938_white_spotting0.82284701
82MP0002063_abnormal_learning/memory/cond0.82182199
83MP0001764_abnormal_homeostasis0.82062956
84MP0009780_abnormal_chondrocyte_physiolo0.81488225
85MP0004087_abnormal_muscle_fiber0.80987486
86MP0004130_abnormal_muscle_cell0.80742328
87MP0002932_abnormal_joint_morphology0.79451108
88MP0005595_abnormal_vascular_smooth0.77599500
89MP0005369_muscle_phenotype0.74966512
90MP0002572_abnormal_emotion/affect_behav0.73573235
91MP0005501_abnormal_skin_physiology0.72087617
92MP0003880_abnormal_central_pattern0.71882675
93MP0005623_abnormal_meninges_morphology0.70805262
94MP0003795_abnormal_bone_structure0.70719943
95MP0005646_abnormal_pituitary_gland0.70601145
96MP0003632_abnormal_nervous_system0.70122496
97MP0005171_absent_coat_pigmentation0.69199915
98MP0000383_abnormal_hair_follicle0.66540123
99MP0002876_abnormal_thyroid_physiology0.64892214
100MP0002752_abnormal_somatic_nervous0.63480793

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the phalanges of the 2nd finger (HP:0009541)5.07813728
2Conjunctival hamartoma (HP:0100780)4.73169905
3Fibular aplasia (HP:0002990)4.71562660
4Abnormality of DNA repair (HP:0003254)4.43573247
5Abnormality of the proximal phalanges of the hand (HP:0009834)3.95080820
6Spinal cord lesions (HP:0100561)3.91870668
7Syringomyelia (HP:0003396)3.91870668
8Hamartoma of the eye (HP:0010568)3.62878978
9Palpebral edema (HP:0100540)3.56714511
10Methylmalonic acidemia (HP:0002912)3.49568817
11Aplasia involving bones of the extremities (HP:0009825)3.47499972
12Aplasia involving bones of the upper limbs (HP:0009823)3.47499972
13Aplasia of the phalanges of the hand (HP:0009802)3.47499972
14Hypoplasia of the uterus (HP:0000013)3.29821433
15Abnormality of the 2nd finger (HP:0004100)3.26979701
16Abnormality of vitamin B metabolism (HP:0004340)3.19489001
17Abnormality of the middle phalanges of the toes (HP:0010183)3.19114030
18Adactyly (HP:0009776)3.17508459
19Abnormality of the vitamin B12 metabolism (HP:0004341)3.12215268
20Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.11683936
21Abnormality of the renal cortex (HP:0011035)3.05963154
22Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.05616008
23Submucous cleft hard palate (HP:0000176)3.04343815
24Nephronophthisis (HP:0000090)2.95926121
25Abnormal ciliary motility (HP:0012262)2.93604367
26Symphalangism affecting the phalanges of the hand (HP:0009773)2.91295924
27Abnormality of the phalanges of the 5th finger (HP:0004213)2.77051313
28Absent/shortened dynein arms (HP:0200106)2.74976151
29Dynein arm defect of respiratory motile cilia (HP:0012255)2.74976151
30Hyperglycinemia (HP:0002154)2.74024326
31Bone cyst (HP:0012062)2.73522435
32Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.65716942
33Medial flaring of the eyebrow (HP:0010747)2.63707213
34Megalencephaly (HP:0001355)2.60960572
35Nemaline bodies (HP:0003798)2.60497607
36Abnormal respiratory motile cilium physiology (HP:0012261)2.55951041
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.55054668
38Absent phalangeal crease (HP:0006109)2.52616486
39Pancreatic cysts (HP:0001737)2.50599237
40Short hallux (HP:0010109)2.49973746
41Abnormality of the renal medulla (HP:0100957)2.49933878
42Aplasia/Hypoplasia of the fibula (HP:0006492)2.46385345
43Adenoma sebaceum (HP:0009720)2.42791412
44Angiofibromas (HP:0010615)2.42791412
45Furrowed tongue (HP:0000221)2.39860143
46Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.39117308
47Stomach cancer (HP:0012126)2.37449379
48Abnormality of midbrain morphology (HP:0002418)2.36710952
49Molar tooth sign on MRI (HP:0002419)2.36710952
50Persistence of primary teeth (HP:0006335)2.36194719
51Abnormal respiratory epithelium morphology (HP:0012253)2.33726983
52Abnormal respiratory motile cilium morphology (HP:0005938)2.33726983
53Tubulointerstitial fibrosis (HP:0005576)2.32371432
542-3 toe syndactyly (HP:0004691)2.32243374
55Aplasia/Hypoplasia of the hallux (HP:0008362)2.31969935
56Distal arthrogryposis (HP:0005684)2.31793131
57Ulnar deviation of the wrist (HP:0003049)2.31418271
58Short femoral neck (HP:0100864)2.30941619
59Prominent metopic ridge (HP:0005487)2.29333342
60Aplasia/hypoplasia of the uterus (HP:0008684)2.25048425
61True hermaphroditism (HP:0010459)2.24721049
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.22888872
63Multiple lipomas (HP:0001012)2.22685151
64Prostate neoplasm (HP:0100787)2.21836303
65Type II lissencephaly (HP:0007260)2.21155532
66Mesomelia (HP:0003027)2.20770967
67Pachygyria (HP:0001302)2.15466897
68Ulnar deviation of finger (HP:0009465)2.15139922
69Methylmalonic aciduria (HP:0012120)2.14574588
70Meckel diverticulum (HP:0002245)2.14461155
71Abnormality of the ileum (HP:0001549)2.13335223
72Congenital stationary night blindness (HP:0007642)2.13050784
73Small hand (HP:0200055)2.10747928
74Synostosis of carpal bones (HP:0005048)2.09115108
75Cavernous hemangioma (HP:0001048)2.08936590
76Aplasia/hypoplasia of the femur (HP:0005613)2.03989208
77Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.03617263
78Round ear (HP:0100830)2.02359303
79Lissencephaly (HP:0001339)2.01973631
80Rhinitis (HP:0012384)1.99767892
81Meningioma (HP:0002858)1.99355464
82Oligodontia (HP:0000677)1.98503305
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98374700
84Abolished electroretinogram (ERG) (HP:0000550)1.98148398
85Hypoplasia of the ulna (HP:0003022)1.98025171
86Abnormality of the preputium (HP:0100587)1.98003149
87Severe visual impairment (HP:0001141)1.96690068
88Muscle fiber inclusion bodies (HP:0100299)1.95303489
89Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.95079930
90Coronal craniosynostosis (HP:0004440)1.92120046
91Abnormal number of incisors (HP:0011064)1.91036365
92Abnormality of vitamin metabolism (HP:0100508)1.89887368
93Abnormal finger flexion creases (HP:0006143)1.88515433
94Arteriovenous malformation (HP:0100026)1.88318115
95Pancreatic fibrosis (HP:0100732)1.87110065
96Abnormality of the metopic suture (HP:0005556)1.86325651
97Cerebral edema (HP:0002181)1.85988759
98Tubulointerstitial abnormality (HP:0001969)1.85573537
99Tubular atrophy (HP:0000092)1.85033191
100Postaxial hand polydactyly (HP:0001162)1.84082428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK27.34924131
2IRAK15.55014940
3MAP4K24.69159143
4MARK13.44704481
5NME22.89138725
6MAPK132.74674382
7YES12.66077902
8MAP3K122.44306774
9DYRK22.43352591
10MAP2K72.42193631
11RPS6KB22.25676113
12ARAF2.10697949
13TIE12.05351849
14CASK1.78598903
15VRK11.77569312
16PTK2B1.61229878
17MAP3K91.45187942
18EPHB21.38417974
19LIMK11.26903142
20MOS1.23218217
21MYLK1.22170367
22MAP3K41.20799155
23CSNK1G21.18569802
24ERBB31.15741219
25AKT31.12290602
26NEK91.12166624
27WNK41.09197156
28MAP3K131.02425938
29NUAK11.00546024
30SGK20.99230370
31MAPKAPK30.96636395
32CAMKK20.96220737
33EIF2AK10.93147815
34GSK3A0.91394904
35DMPK0.89435937
36SGK2230.86216567
37SGK4940.86216567
38TEC0.83585764
39CSNK1G10.83331782
40OBSCN0.83095948
41ROCK20.83069957
42TNIK0.80703088
43PAK30.79339394
44CDK50.79271929
45CCNB10.79130514
46ROCK10.76784436
47PLK20.75509914
48PHKG20.74149518
49PHKG10.74149518
50PIK3CG0.72013152
51GRK10.71478697
52FRK0.69681144
53ADRBK20.69537040
54SGK30.66340918
55IGF1R0.65273006
56ILK0.63622807
57RAF10.63571156
58PRKG20.63000920
59PRKCE0.60423672
60WNK10.60163543
61TRPM70.59663037
62BRAF0.59295448
63PINK10.58046035
64TLK10.51801162
65DAPK10.51633479
66NTRK10.51286040
67PRKG10.51105721
68DDR20.50507001
69CSNK1G30.50414097
70RPS6KB10.49248185
71TESK10.48136380
72MUSK0.47896905
73CSNK1A10.46472490
74PLK30.45240705
75MAP2K10.44635266
76MAPK70.44249555
77DAPK20.42311056
78CSNK1A1L0.40194345
79KSR20.38293192
80EIF2AK30.38273146
81ABL10.37815957
82BMPR1B0.36496487
83WNK30.36007768
84STK390.34476419
85AURKA0.33198925
86SGK10.31807662
87EGFR0.31329437
88GRK50.29280786
89CDK150.28960230
90EIF2AK20.28369884
91PRKACA0.26622742
92CDK180.26594467
93GRK60.26584446
94MAPK90.26554489
95PIK3CA0.26313484
96NTRK20.25363333
97MAP3K10.25099362
98TRIM280.24394569
99CDK11A0.20285579
100MAPK80.19360245

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.54421957
2Regulation of autophagy_Homo sapiens_hsa041403.62876971
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.60371367
4Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.33856233
5Basal transcription factors_Homo sapiens_hsa030222.33104760
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.18480384
7Phototransduction_Homo sapiens_hsa047441.76057846
8Dopaminergic synapse_Homo sapiens_hsa047281.69184618
9Melanoma_Homo sapiens_hsa052181.64597614
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58643624
11cGMP-PKG signaling pathway_Homo sapiens_hsa040221.58203190
12Autoimmune thyroid disease_Homo sapiens_hsa053201.55255776
13Proteasome_Homo sapiens_hsa030501.53382891
14Olfactory transduction_Homo sapiens_hsa047401.47322364
15Allograft rejection_Homo sapiens_hsa053301.45523141
16Salivary secretion_Homo sapiens_hsa049701.45125043
17Nicotine addiction_Homo sapiens_hsa050331.40279380
18Tight junction_Homo sapiens_hsa045301.32782646
19Insulin secretion_Homo sapiens_hsa049111.25996601
20Oxytocin signaling pathway_Homo sapiens_hsa049211.20108959
21Serotonergic synapse_Homo sapiens_hsa047261.17653482
22Ras signaling pathway_Homo sapiens_hsa040141.15448888
23Alzheimers disease_Homo sapiens_hsa050101.13936923
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13075747
25Protein digestion and absorption_Homo sapiens_hsa049741.12598198
26Cardiac muscle contraction_Homo sapiens_hsa042601.10532227
27MAPK signaling pathway_Homo sapiens_hsa040101.10504431
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09289879
29Morphine addiction_Homo sapiens_hsa050321.08649096
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08363357
31Type I diabetes mellitus_Homo sapiens_hsa049401.08335192
32Calcium signaling pathway_Homo sapiens_hsa040201.07796225
33Long-term depression_Homo sapiens_hsa047301.07577957
34Axon guidance_Homo sapiens_hsa043601.06523862
35Circadian entrainment_Homo sapiens_hsa047131.06513401
36Renin secretion_Homo sapiens_hsa049241.04793980
37Platelet activation_Homo sapiens_hsa046111.04621737
38Vascular smooth muscle contraction_Homo sapiens_hsa042701.04385499
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02741212
40Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01871694
41Gastric acid secretion_Homo sapiens_hsa049711.01576368
42GABAergic synapse_Homo sapiens_hsa047271.01411968
43Long-term potentiation_Homo sapiens_hsa047200.99550683
44Hedgehog signaling pathway_Homo sapiens_hsa043400.95329717
45Estrogen signaling pathway_Homo sapiens_hsa049150.94391476
46Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94238213
47Taste transduction_Homo sapiens_hsa047420.92384413
48Nucleotide excision repair_Homo sapiens_hsa034200.91126407
49Glutamatergic synapse_Homo sapiens_hsa047240.90301072
50Hematopoietic cell lineage_Homo sapiens_hsa046400.89130666
51Cholinergic synapse_Homo sapiens_hsa047250.87777465
52Ether lipid metabolism_Homo sapiens_hsa005650.86528623
53Huntingtons disease_Homo sapiens_hsa050160.86281598
54Glioma_Homo sapiens_hsa052140.86009878
55Herpes simplex infection_Homo sapiens_hsa051680.85947493
56Arginine biosynthesis_Homo sapiens_hsa002200.81112183
57RNA degradation_Homo sapiens_hsa030180.80678095
58Chemical carcinogenesis_Homo sapiens_hsa052040.80182484
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.78716434
60Oxidative phosphorylation_Homo sapiens_hsa001900.78192866
61Parkinsons disease_Homo sapiens_hsa050120.77102206
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71812208
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71254578
64TGF-beta signaling pathway_Homo sapiens_hsa043500.71011329
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70017026
66Dorso-ventral axis formation_Homo sapiens_hsa043200.69054591
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68265419
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66813009
69Wnt signaling pathway_Homo sapiens_hsa043100.66330138
70Graft-versus-host disease_Homo sapiens_hsa053320.65802004
71Protein export_Homo sapiens_hsa030600.65801333
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65311851
73mRNA surveillance pathway_Homo sapiens_hsa030150.64548179
74Fanconi anemia pathway_Homo sapiens_hsa034600.63400093
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63265956
76PI3K-Akt signaling pathway_Homo sapiens_hsa041510.63143965
77Focal adhesion_Homo sapiens_hsa045100.62773122
78Amphetamine addiction_Homo sapiens_hsa050310.62492815
79Circadian rhythm_Homo sapiens_hsa047100.61804088
80Nitrogen metabolism_Homo sapiens_hsa009100.61424676
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61118456
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58202973
83Hippo signaling pathway_Homo sapiens_hsa043900.58054013
84Propanoate metabolism_Homo sapiens_hsa006400.56677132
85Cocaine addiction_Homo sapiens_hsa050300.56461841
86Gap junction_Homo sapiens_hsa045400.56171758
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55200441
88TNF signaling pathway_Homo sapiens_hsa046680.55083657
89Prolactin signaling pathway_Homo sapiens_hsa049170.54352984
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53836230
91cAMP signaling pathway_Homo sapiens_hsa040240.53650381
92Dilated cardiomyopathy_Homo sapiens_hsa054140.52322919
93N-Glycan biosynthesis_Homo sapiens_hsa005100.51946481
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48754997
95Renin-angiotensin system_Homo sapiens_hsa046140.47830860
96Linoleic acid metabolism_Homo sapiens_hsa005910.47806502
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.45187645
98Pancreatic secretion_Homo sapiens_hsa049720.42845451
99Rap1 signaling pathway_Homo sapiens_hsa040150.42699170
100Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42635966

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