RANGRF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.77369926
2chaperone-mediated protein transport (GO:0072321)5.36592760
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.20857577
4protein complex biogenesis (GO:0070271)5.04866685
5ribosomal small subunit assembly (GO:0000028)5.03096151
6mitochondrial respiratory chain complex assembly (GO:0033108)4.90362647
7respiratory electron transport chain (GO:0022904)4.87921162
8electron transport chain (GO:0022900)4.76934681
9mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.56645464
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.56645464
11NADH dehydrogenase complex assembly (GO:0010257)4.56645464
12respiratory chain complex IV assembly (GO:0008535)4.55753862
13maturation of SSU-rRNA (GO:0030490)4.55501654
14protein neddylation (GO:0045116)4.54824330
15viral transcription (GO:0019083)4.37252803
16cytochrome complex assembly (GO:0017004)4.33196151
17translational termination (GO:0006415)4.30009387
18pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.21466494
19binding of sperm to zona pellucida (GO:0007339)4.20762587
20DNA strand elongation involved in DNA replication (GO:0006271)4.15007731
21translational elongation (GO:0006414)4.08767368
22sperm-egg recognition (GO:0035036)4.08070265
23ribosomal large subunit biogenesis (GO:0042273)4.05914983
24ribosomal small subunit biogenesis (GO:0042274)4.05133842
25DNA replication initiation (GO:0006270)3.98163856
26telomere maintenance via semi-conservative replication (GO:0032201)3.96279194
27DNA strand elongation (GO:0022616)3.94588894
28formation of translation preinitiation complex (GO:0001731)3.93963646
29nucleobase biosynthetic process (GO:0046112)3.86795838
30establishment of integrated proviral latency (GO:0075713)3.86052734
31protein targeting to mitochondrion (GO:0006626)3.83365265
32ribonucleoprotein complex biogenesis (GO:0022613)3.83051325
33translational initiation (GO:0006413)3.75891658
34spliceosomal snRNP assembly (GO:0000387)3.74886909
35ribosome biogenesis (GO:0042254)3.73565151
36establishment of protein localization to mitochondrion (GO:0072655)3.70596244
37chromatin remodeling at centromere (GO:0031055)3.69734908
38fusion of sperm to egg plasma membrane (GO:0007342)3.68567116
39cilium or flagellum-dependent cell motility (GO:0001539)3.67451743
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.66943566
41pseudouridine synthesis (GO:0001522)3.65352076
42ATP biosynthetic process (GO:0006754)3.64329584
43purine nucleobase biosynthetic process (GO:0009113)3.63972463
44deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.62889643
45CENP-A containing nucleosome assembly (GO:0034080)3.61396386
46RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.60835919
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.60835919
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.60269667
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.60269667
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.60269667
51cell-cell recognition (GO:0009988)3.58479086
52cotranslational protein targeting to membrane (GO:0006613)3.57627891
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.57266311
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.57266311
55regulation of cellular amino acid metabolic process (GO:0006521)3.56552834
56protein targeting to ER (GO:0045047)3.55778561
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55425020
58piRNA metabolic process (GO:0034587)3.54344165
59nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.54285765
60DNA replication-dependent nucleosome organization (GO:0034723)3.51948943
61DNA replication-dependent nucleosome assembly (GO:0006335)3.51948943
62protein localization to mitochondrion (GO:0070585)3.51117217
63histone exchange (GO:0043486)3.50992628
64purine nucleoside triphosphate biosynthetic process (GO:0009145)3.48286534
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.48028506
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47495218
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.47495218
68rRNA processing (GO:0006364)3.46831508
69cellular protein complex disassembly (GO:0043624)3.46334419
70telomere maintenance via recombination (GO:0000722)3.45106910
71rRNA modification (GO:0000154)3.44450214
72signal transduction involved in cell cycle checkpoint (GO:0072395)3.43879150
73purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.42529151
74proteasome assembly (GO:0043248)3.42105463
75pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.40785544
76motile cilium assembly (GO:0044458)3.40377474
77DNA unwinding involved in DNA replication (GO:0006268)3.40326542
78sperm motility (GO:0030317)3.40252440
79pyrimidine nucleotide catabolic process (GO:0006244)3.39118208
80deoxyribonucleotide catabolic process (GO:0009264)3.38352668
81establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38336968
82rRNA metabolic process (GO:0016072)3.37825939
83inner mitochondrial membrane organization (GO:0007007)3.37109923
84ribosome assembly (GO:0042255)3.36485441
85IMP biosynthetic process (GO:0006188)3.35677346
86protein localization to endoplasmic reticulum (GO:0070972)3.35390582
87translation (GO:0006412)3.35299316
88viral life cycle (GO:0019058)3.34549324
89axonemal dynein complex assembly (GO:0070286)3.34499741
90termination of RNA polymerase III transcription (GO:0006386)3.28631272
91transcription elongation from RNA polymerase III promoter (GO:0006385)3.28631272
92DNA replication checkpoint (GO:0000076)3.27623874
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27289795
94base-excision repair, AP site formation (GO:0006285)3.26037471
95iron-sulfur cluster assembly (GO:0016226)3.25244228
96metallo-sulfur cluster assembly (GO:0031163)3.25244228
97regulation of mitochondrial translation (GO:0070129)3.25202102
98mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24968207
99deoxyribose phosphate catabolic process (GO:0046386)3.23967546
100intracellular protein transmembrane import (GO:0044743)3.23670776
101cellular component biogenesis (GO:0044085)3.20619681
102ribonucleoside triphosphate biosynthetic process (GO:0009201)3.18788731
103DNA replication-independent nucleosome assembly (GO:0006336)3.18443389
104DNA replication-independent nucleosome organization (GO:0034724)3.18443389
105positive regulation of ligase activity (GO:0051351)3.17737056
106negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.17596526
107protein complex disassembly (GO:0043241)3.17245709
108protein targeting to membrane (GO:0006612)3.16302551
109nuclear-transcribed mRNA catabolic process (GO:0000956)3.16072025
110protein deneddylation (GO:0000338)3.15649580
111telomere maintenance via telomere lengthening (GO:0010833)3.14873368
112hydrogen ion transmembrane transport (GO:1902600)3.14531859
113cell wall macromolecule catabolic process (GO:0016998)3.14442386
114cell wall macromolecule metabolic process (GO:0044036)3.14442386
115mitotic recombination (GO:0006312)3.12732832
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12584111
117spermatid development (GO:0007286)3.11628369
118peptidyl-histidine modification (GO:0018202)3.09243918
119exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.09225535
120chaperone-mediated protein complex assembly (GO:0051131)3.08726886
121UTP biosynthetic process (GO:0006228)3.06004439
122synaptonemal complex assembly (GO:0007130)3.05966607
123transcription-coupled nucleotide-excision repair (GO:0006283)3.05846259
124pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.05801827
125anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05457677
126male meiosis (GO:0007140)3.05205411
127GTP biosynthetic process (GO:0006183)3.04536137
128oxidative phosphorylation (GO:0006119)3.04205821
1292-deoxyribonucleotide metabolic process (GO:0009394)3.04063651
130positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03993096
131IMP metabolic process (GO:0046040)3.03877152
132macromolecular complex disassembly (GO:0032984)3.03191483
133mitotic nuclear envelope disassembly (GO:0007077)3.02961709
134nucleotide-excision repair, DNA gap filling (GO:0006297)3.01932964
135protein localization to chromosome, centromeric region (GO:0071459)3.01264207
136spliceosomal complex assembly (GO:0000245)2.99421909
137guanosine-containing compound biosynthetic process (GO:1901070)2.99114864
138synaptonemal complex organization (GO:0070193)2.98487273
139negative regulation of ligase activity (GO:0051352)2.98003479
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98003479
141establishment of protein localization to mitochondrial membrane (GO:0090151)2.97689710
142mitotic metaphase plate congression (GO:0007080)2.97379958
143nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96567979
144viral mRNA export from host cell nucleus (GO:0046784)2.95918965
145ATP synthesis coupled proton transport (GO:0015986)2.94388790
146energy coupled proton transport, down electrochemical gradient (GO:0015985)2.94388790
147DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.92846649
148protein complex localization (GO:0031503)2.92680449
1497-methylguanosine mRNA capping (GO:0006370)2.92535921
150cullin deneddylation (GO:0010388)2.92406126

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.20576661
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.58386283
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.28565094
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96303621
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50813805
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.38578998
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.35185186
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.25927534
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.25522704
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.13556049
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.08642524
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97403164
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97170668
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91589205
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78760033
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.63336600
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60390570
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54270625
19* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47028477
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.45837297
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44518893
22XRN2_22483619_ChIP-Seq_HELA_Human2.38556801
23VDR_23849224_ChIP-Seq_CD4+_Human2.35421255
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19220713
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18627648
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.18213770
27DCP1A_22483619_ChIP-Seq_HELA_Human2.09727195
28FOXP3_21729870_ChIP-Seq_TREG_Human2.08487812
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07113799
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.05574530
31GABP_19822575_ChIP-Seq_HepG2_Human2.03292070
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02560828
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.99439118
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91736518
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.88270492
36ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87939983
37TTF2_22483619_ChIP-Seq_HELA_Human1.86776212
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83173027
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81419394
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75360718
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73603706
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.72312168
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69862467
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64843728
45AR_21909140_ChIP-Seq_LNCAP_Human1.59968697
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57879345
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.57230639
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55266829
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55195094
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54070634
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.53544167
52FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45164396
53ELK1_19687146_ChIP-ChIP_HELA_Human1.44869799
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41103729
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.38494462
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35262880
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35053606
58CIITA_25753668_ChIP-Seq_RAJI_Human1.34577753
59PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29973198
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27346397
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26432807
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26189126
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26120785
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.24435626
65NOTCH1_21737748_ChIP-Seq_TLL_Human1.24408506
66KDM5A_27292631_Chip-Seq_BREAST_Human1.23172588
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17854797
68ZNF274_21170338_ChIP-Seq_K562_Hela1.15691806
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14752440
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13674720
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12712494
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11333942
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10538160
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.10238305
75* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07541759
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.06986949
77MYC_18940864_ChIP-ChIP_HL60_Human1.04148017
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02934285
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02485682
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.02164196
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01827767
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00934112
83DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99306428
84YY1_22570637_ChIP-Seq_MALME-3M_Human0.98859570
85CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98434827
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97620041
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95481679
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.94333963
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90290051
90RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.88675882
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88052819
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87283837
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.86670361
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83944440
95GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83474993
96TP53_22573176_ChIP-Seq_HFKS_Human0.81607397
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80967742
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80785335
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.80477200
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.79611322
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.77805416
102* TFEB_21752829_ChIP-Seq_HELA_Human0.77738213
103* FOXP1_21924763_ChIP-Seq_HESCs_Human0.77479003
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.76902973
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76877780
106ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76828643
107SOX2_16153702_ChIP-ChIP_HESCs_Human0.76370628
108MYC_22102868_ChIP-Seq_BL_Human0.75241555
109SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.75166634
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74258473
111SRY_22984422_ChIP-ChIP_TESTIS_Rat0.73355439
112CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73234675
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72532123
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.72518189
115CTCF_26484167_Chip-Seq_Bcells_Mouse0.71410599
116EWS_26573619_Chip-Seq_HEK293_Human0.69002777
117BCL6_27268052_Chip-Seq_Bcells_Human0.68885361
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.68113813

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.09528944
2MP0003693_abnormal_embryo_hatching4.77537896
3MP0010094_abnormal_chromosome_stability4.29178917
4MP0004957_abnormal_blastocyst_morpholog4.05307751
5MP0003111_abnormal_nucleus_morphology3.80631265
6MP0008877_abnormal_DNA_methylation3.73622215
7MP0008058_abnormal_DNA_repair3.69540019
8MP0008057_abnormal_DNA_replication3.50763276
9MP0003077_abnormal_cell_cycle3.48874266
10MP0000372_irregular_coat_pigmentation2.93107664
11MP0001929_abnormal_gametogenesis2.65472439
12MP0008007_abnormal_cellular_replicative2.65373823
13MP0003806_abnormal_nucleotide_metabolis2.50289456
14MP0005084_abnormal_gallbladder_morpholo2.38505170
15MP0003698_abnormal_male_reproductive2.37499112
16MP0003646_muscle_fatigue2.34649544
17MP0008932_abnormal_embryonic_tissue2.34550499
18MP0002210_abnormal_sex_determination2.23682260
19MP0002938_white_spotting2.23659503
20MP0006036_abnormal_mitochondrial_physio2.17576660
21MP0003123_paternal_imprinting2.15663218
22MP0008789_abnormal_olfactory_epithelium2.10872048
23MP0002163_abnormal_gland_morphology2.09424608
24MP0001730_embryonic_growth_arrest2.03561985
25MP0003786_premature_aging2.00544670
26MP0001145_abnormal_male_reproductive1.98590691
27MP0003136_yellow_coat_color1.98141141
28MP0002396_abnormal_hematopoietic_system1.95929481
29MP0002102_abnormal_ear_morphology1.92695651
30MP0006035_abnormal_mitochondrial_morpho1.78014287
31MP0009697_abnormal_copulation1.77243171
32MP0000350_abnormal_cell_proliferation1.72061127
33MP0002277_abnormal_respiratory_mucosa1.70645944
34MP0002736_abnormal_nociception_after1.69939960
35MP0000653_abnormal_sex_gland1.67295180
36MP0005499_abnormal_olfactory_system1.58699896
37MP0005394_taste/olfaction_phenotype1.58699896
38MP0004084_abnormal_cardiac_muscle1.48597988
39MP0001697_abnormal_embryo_size1.48445862
40MP0002160_abnormal_reproductive_system1.48414942
41MP0000313_abnormal_cell_death1.47208877
42MP0003186_abnormal_redox_activity1.44451863
43MP0006072_abnormal_retinal_apoptosis1.43731082
44MP0002837_dystrophic_cardiac_calcinosis1.43386969
45MP0004215_abnormal_myocardial_fiber1.42677577
46MP0002653_abnormal_ependyma_morphology1.42602238
47MP0005671_abnormal_response_to1.39125546
48MP0001672_abnormal_embryogenesis/_devel1.38861299
49MP0005380_embryogenesis_phenotype1.38861299
50MP0009379_abnormal_foot_pigmentation1.38661767
51MP0001905_abnormal_dopamine_level1.38279960
52MP0002080_prenatal_lethality1.37606239
53MP0004142_abnormal_muscle_tone1.37373808
54MP0004808_abnormal_hematopoietic_stem1.37292257
55MP0000358_abnormal_cell_content/1.36028407
56MP0002161_abnormal_fertility/fecundity1.35792780
57MP0000490_abnormal_crypts_of1.35424985
58MP0005645_abnormal_hypothalamus_physiol1.34294405
59MP0001545_abnormal_hematopoietic_system1.34192856
60MP0005397_hematopoietic_system_phenotyp1.34192856
61MP0003011_delayed_dark_adaptation1.33727547
62MP0004147_increased_porphyrin_level1.33126253
63MP0001293_anophthalmia1.33015587
64MP0001968_abnormal_touch/_nociception1.32779760
65MP0005646_abnormal_pituitary_gland1.31989278
66MP0003984_embryonic_growth_retardation1.28632000
67MP0003567_abnormal_fetal_cardiomyocyte1.25711236
68MP0004133_heterotaxia1.24446105
69MP0003718_maternal_effect1.23632082
70MP0002088_abnormal_embryonic_growth/wei1.23197813
71MP0000749_muscle_degeneration1.22523376
72MP0000049_abnormal_middle_ear1.22225987
73MP0002132_abnormal_respiratory_system1.21645146
74MP0006054_spinal_hemorrhage1.16108556
75MP0005551_abnormal_eye_electrophysiolog1.15649929
76MP0002269_muscular_atrophy1.15375409
77MP0006292_abnormal_olfactory_placode1.15015684
78MP0005379_endocrine/exocrine_gland_phen1.13457337
79MP0002019_abnormal_tumor_incidence1.12496171
80MP0010307_abnormal_tumor_latency1.12454238
81MP0000750_abnormal_muscle_regeneration1.11205450
82MP0002085_abnormal_embryonic_tissue1.10270990
83MP0003880_abnormal_central_pattern1.10043573
84MP0002638_abnormal_pupillary_reflex1.09071788
85MP0010352_gastrointestinal_tract_polyps1.07590623
86MP0004233_abnormal_muscle_weight1.05845389
87MP0005171_absent_coat_pigmentation1.05295198
88MP0005266_abnormal_metabolism1.05048199
89MP0005330_cardiomyopathy1.02168648
90MP0001853_heart_inflammation1.01065325
91MP0000631_abnormal_neuroendocrine_gland1.00462711
92MP0005253_abnormal_eye_physiology0.99595095
93MP0002084_abnormal_developmental_patter0.97746175
94MP0002148_abnormal_hypersensitivity_rea0.96423698
95MP0003195_calcinosis0.95135197
96MP0002086_abnormal_extraembryonic_tissu0.92422484
97MP0009333_abnormal_splenocyte_physiolog0.91671103
98MP0004036_abnormal_muscle_relaxation0.89947438
99MP0003315_abnormal_perineum_morphology0.89486054
100MP0005389_reproductive_system_phenotype0.89262327
101MP0002751_abnormal_autonomic_nervous0.87807221
102MP0001984_abnormal_olfaction0.86792163
103MP0003221_abnormal_cardiomyocyte_apopto0.86180190
104MP0005670_abnormal_white_adipose0.86068212
105MP0005075_abnormal_melanosome_morpholog0.85614424
106MP0004197_abnormal_fetal_growth/weight/0.85173902
107MP0005408_hypopigmentation0.84774776
108MP0000703_abnormal_thymus_morphology0.79886602
109MP0001764_abnormal_homeostasis0.77922930
110MP0001835_abnormal_antigen_presentation0.76178323
111MP0000751_myopathy0.76062011
112MP0001919_abnormal_reproductive_system0.75820890
113MP0005174_abnormal_tail_pigmentation0.74943394
114MP0002106_abnormal_muscle_physiology0.72812094
115MP0001324_abnormal_eye_pigmentation0.71854689
116MP0003763_abnormal_thymus_physiology0.71068778
117MP0008872_abnormal_physiological_respon0.70563107
118MP0001529_abnormal_vocalization0.68255709
119MP0001800_abnormal_humoral_immune0.67659043
120MP0010630_abnormal_cardiac_muscle0.67608497
121MP0002722_abnormal_immune_system0.67591021
122MP0005195_abnormal_posterior_eye0.66786774
123MP0001188_hyperpigmentation0.66518110
124MP0002127_abnormal_cardiovascular_syste0.65621578
125MP0005332_abnormal_amino_acid0.65307533
126MP0000689_abnormal_spleen_morphology0.64216047
127MP0003121_genomic_imprinting0.63859401
128MP0001119_abnormal_female_reproductive0.63652269
129MP0010030_abnormal_orbit_morphology0.63435125
130MP0008875_abnormal_xenobiotic_pharmacok0.63346035
131MP0002282_abnormal_trachea_morphology0.62481129
132MP0003787_abnormal_imprinting0.62364272
133MP0005391_vision/eye_phenotype0.62203161
134MP0002398_abnormal_bone_marrow0.62042569
135MP0000026_abnormal_inner_ear0.61518656
136MP0002234_abnormal_pharynx_morphology0.61480792
137MP0009046_muscle_twitch0.60659414
138MP0009745_abnormal_behavioral_response0.60588782
139MP0003656_abnormal_erythrocyte_physiolo0.60430535
140MP0008873_increased_physiological_sensi0.59984308
141MP0008995_early_reproductive_senescence0.59921749
142MP0009785_altered_susceptibility_to0.59898702
143MP0003122_maternal_imprinting0.59496238
144MP0001986_abnormal_taste_sensitivity0.58751705
145MP0003890_abnormal_embryonic-extraembry0.57485371
146MP0003137_abnormal_impulse_conducting0.56879433
147MP0004087_abnormal_muscle_fiber0.56650397
148MP0003119_abnormal_digestive_system0.56474572
149MP0000747_muscle_weakness0.55656506
150MP0005384_cellular_phenotype0.55130325
151MP0001544_abnormal_cardiovascular_syste0.54730861
152MP0005385_cardiovascular_system_phenoty0.54730861
153MP0002095_abnormal_skin_pigmentation0.54108189

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.31148053
2Abnormal number of erythroid precursors (HP:0012131)5.21301633
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.94734273
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.60715255
5Absent/shortened dynein arms (HP:0200106)4.60715255
6Renal Fanconi syndrome (HP:0001994)4.17803001
7Reticulocytopenia (HP:0001896)4.13289406
8Abnormal respiratory motile cilium morphology (HP:0005938)4.10802779
9Abnormal respiratory epithelium morphology (HP:0012253)4.10802779
10Birth length less than 3rd percentile (HP:0003561)3.95173832
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.86618486
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.86618486
13Chronic bronchitis (HP:0004469)3.66876882
14Acute necrotizing encephalopathy (HP:0006965)3.64079316
15Abnormal mitochondria in muscle tissue (HP:0008316)3.50878911
16Oral leukoplakia (HP:0002745)3.47597471
17Aplastic anemia (HP:0001915)3.47331776
18Abnormal respiratory motile cilium physiology (HP:0012261)3.38086889
19Mitochondrial inheritance (HP:0001427)3.37729298
20Hepatocellular necrosis (HP:0001404)3.32692509
21Increased CSF lactate (HP:0002490)3.28667213
22Increased serum lactate (HP:0002151)3.12809604
23Macrocytic anemia (HP:0001972)3.09021387
24Rhinitis (HP:0012384)3.01359210
25Pallor (HP:0000980)2.98102583
26Hepatic necrosis (HP:0002605)2.97580042
27Breast hypoplasia (HP:0003187)2.92791123
28Optic disc pallor (HP:0000543)2.87741284
29Acute encephalopathy (HP:0006846)2.86907192
30Progressive macrocephaly (HP:0004481)2.81725128
31Selective tooth agenesis (HP:0001592)2.79645566
32Degeneration of anterior horn cells (HP:0002398)2.76036972
33Abnormality of the anterior horn cell (HP:0006802)2.76036972
34Increased hepatocellular lipid droplets (HP:0006565)2.71254689
35Exercise intolerance (HP:0003546)2.71095361
36Cerebral hypomyelination (HP:0006808)2.65980555
37Abnormal spermatogenesis (HP:0008669)2.63469372
38Abnormality of glycolysis (HP:0004366)2.62541707
39Increased serum pyruvate (HP:0003542)2.62541707
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60634369
41Lactic acidosis (HP:0003128)2.59626371
42Supernumerary spleens (HP:0009799)2.59024109
43Lipid accumulation in hepatocytes (HP:0006561)2.56791284
44Leukodystrophy (HP:0002415)2.54327950
45Rhabdomyolysis (HP:0003201)2.53664423
46Microvesicular hepatic steatosis (HP:0001414)2.52548852
47Nasal polyposis (HP:0100582)2.51352324
48Abnormal ciliary motility (HP:0012262)2.51090350
49Carpal bone hypoplasia (HP:0001498)2.50810466
50Colon cancer (HP:0003003)2.48235483
51Pancreatic fibrosis (HP:0100732)2.47203736
52Rough bone trabeculation (HP:0100670)2.46570888
53Absent thumb (HP:0009777)2.44961563
5411 pairs of ribs (HP:0000878)2.44823903
55True hermaphroditism (HP:0010459)2.41145528
56Abnormality of alanine metabolism (HP:0010916)2.38963117
57Hyperalaninemia (HP:0003348)2.38963117
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38963117
59Methylmalonic aciduria (HP:0012120)2.38872709
60Cerebellar dysplasia (HP:0007033)2.37067913
61Abnormality of the heme biosynthetic pathway (HP:0010472)2.35668606
62Testicular atrophy (HP:0000029)2.35535261
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35421988
64Abnormality of renal resorption (HP:0011038)2.34413813
65Increased intramyocellular lipid droplets (HP:0012240)2.34289623
66Pancytopenia (HP:0001876)2.33786376
67Hyperglycinemia (HP:0002154)2.32635957
68Lethargy (HP:0001254)2.32525393
69Pancreatic cysts (HP:0001737)2.31326670
70Microretrognathia (HP:0000308)2.30805352
71Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30606010
72Abnormality of the preputium (HP:0100587)2.28511821
733-Methylglutaconic aciduria (HP:0003535)2.27881009
74Medial flaring of the eyebrow (HP:0010747)2.27674820
75Abnormality of the labia minora (HP:0012880)2.27437061
76Type II lissencephaly (HP:0007260)2.25660445
77Infertility (HP:0000789)2.23672961
78Abnormality of midbrain morphology (HP:0002418)2.22704235
79Molar tooth sign on MRI (HP:0002419)2.22704235
80Chromsome breakage (HP:0040012)2.22041269
81Respiratory failure (HP:0002878)2.21444962
82Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19490868
83Type I transferrin isoform profile (HP:0003642)2.18155077
84Increased muscle lipid content (HP:0009058)2.16230931
85Abnormality of the nasal mucosa (HP:0000433)2.14504931
86Progressive muscle weakness (HP:0003323)2.14420064
87Type 2 muscle fiber atrophy (HP:0003554)2.13811512
88Multiple enchondromatosis (HP:0005701)2.13024883
89Muscle fiber atrophy (HP:0100295)2.12504625
90Premature ovarian failure (HP:0008209)2.12493675
91Meckel diverticulum (HP:0002245)2.12048576
92CNS demyelination (HP:0007305)2.09709363
93Premature graying of hair (HP:0002216)2.08729705
94Exertional dyspnea (HP:0002875)2.07560735
95Hypoplasia of the pons (HP:0012110)2.06757893
96Impulsivity (HP:0100710)2.06700196
97Bronchitis (HP:0012387)2.05812970
98Gonadotropin excess (HP:0000837)2.05240968
99Abnormality of the ileum (HP:0001549)2.04806816
100Facial cleft (HP:0002006)2.02858122
101Myelodysplasia (HP:0002863)2.01812774
102Trismus (HP:0000211)1.98474565
103Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98455086
104Cerebral edema (HP:0002181)1.98177261
105Emotional lability (HP:0000712)1.97292878
106Abnormal protein glycosylation (HP:0012346)1.96132773
107Abnormal glycosylation (HP:0012345)1.96132773
108Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96132773
109Abnormal protein N-linked glycosylation (HP:0012347)1.96132773
110Cleft eyelid (HP:0000625)1.95483463
111Glycosuria (HP:0003076)1.94727108
112Abnormality of urine glucose concentration (HP:0011016)1.94727108
113Respiratory difficulties (HP:0002880)1.93477603
114Medulloblastoma (HP:0002885)1.92840680
115Dicarboxylic aciduria (HP:0003215)1.91284405
116Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91284405
117Thrombocytosis (HP:0001894)1.90769402
118Secondary amenorrhea (HP:0000869)1.89959478
119Myoglobinuria (HP:0002913)1.89308596
120Sloping forehead (HP:0000340)1.89271823
121Bone marrow hypocellularity (HP:0005528)1.88844927
122Bronchiectasis (HP:0002110)1.87835488
123Congenital stationary night blindness (HP:0007642)1.87728159
124Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.86688583
125Unsteady gait (HP:0002317)1.86344567
126Cellular immunodeficiency (HP:0005374)1.85297359
127Abnormality of chromosome stability (HP:0003220)1.84669882
128Sclerocornea (HP:0000647)1.84092198
129Methylmalonic acidemia (HP:0002912)1.83495450
130Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83282894
131Patellar aplasia (HP:0006443)1.83046306
132Retinal dysplasia (HP:0007973)1.81206910
133Abnormality of the pons (HP:0007361)1.80896301
134Panhypogammaglobulinemia (HP:0003139)1.80241370
135Generalized aminoaciduria (HP:0002909)1.79690032
136X-linked dominant inheritance (HP:0001423)1.78603872
137Hyperphosphaturia (HP:0003109)1.77438539
138Decreased central vision (HP:0007663)1.73022306
139Triphalangeal thumb (HP:0001199)1.72146084
140Progressive microcephaly (HP:0000253)1.71933918
141Anencephaly (HP:0002323)1.71689094
142Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69298887
143Septo-optic dysplasia (HP:0100842)1.68978812
144Rib fusion (HP:0000902)1.68965019
145Hypoplastic pelvis (HP:0008839)1.67723848
146Abolished electroretinogram (ERG) (HP:0000550)1.66412217
147Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65947956
148Abnormal rod and cone electroretinograms (HP:0008323)1.64133339
149Stenosis of the external auditory canal (HP:0000402)1.63500399
150Blindness (HP:0000618)1.62819237
151Neutropenia (HP:0001875)1.61171902
152Abnormality of serum amino acid levels (HP:0003112)1.61038405
153Attenuation of retinal blood vessels (HP:0007843)1.56979913
154Pendular nystagmus (HP:0012043)1.56380357

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.18684277
2PDK34.33776067
3PDK44.33776067
4WEE14.33178972
5BUB14.24181903
6EIF2AK13.21899426
7CDC73.09823445
8NME22.85346166
9STK162.83673710
10PDK22.52129164
11SRPK12.33774774
12VRK12.27688461
13TESK12.25774690
14NUAK12.22432969
15NEK22.17456619
16PLK42.12270409
17TAF12.04684416
18NEK11.84582528
19TTK1.81101803
20BRSK21.74524033
21EIF2AK31.74333496
22TSSK61.71736445
23ACVR1B1.67177973
24PLK11.65239929
25DYRK31.61012560
26MAP4K21.59040604
27TESK21.50255439
28CDK71.47507663
29ATR1.47407149
30PASK1.43567641
31MST41.39983492
32TLK11.38263883
33CCNB11.36159452
34AURKB1.33370362
35BCKDK1.33338448
36CSNK1G31.28475364
37MAPK151.23268690
38WNK31.22963275
39PNCK1.19931257
40RPS6KB21.17752899
41NME11.17716137
42PIM21.16583394
43CHEK21.13090342
44LIMK11.12702294
45AURKA1.11925708
46TRIM281.11872801
47MKNK11.11198860
48SCYL21.10800435
49MUSK1.10734904
50FLT31.08142220
51TGFBR11.04596701
52KDR1.04057826
53CSNK1G11.02684956
54ADRBK21.01910712
55CSNK1G21.00700883
56ARAF0.98972675
57BRSK10.96842773
58BMPR1B0.95162351
59MAP3K120.94547324
60RPS6KA40.93738186
61TAOK30.93535778
62PAK40.93053071
63CHEK10.92865248
64ZAK0.92566868
65MAP3K110.91909351
66PLK30.91549329
67CDK80.86229530
68MAP3K80.86188163
69MAPKAPK30.84789217
70TXK0.84436415
71MAPKAPK50.83997499
72MAP4K10.83390880
73CSNK1A1L0.83353416
74CDK40.83089073
75MKNK20.82244771
76PINK10.82155092
77BRAF0.79249844
78OBSCN0.79065237
79MAP2K30.78827725
80CSNK2A20.75179602
81CSNK2A10.73943640
82DAPK30.72354523
83ATM0.68778116
84MYLK0.66838777
85ICK0.66470504
86CDK190.65632456
87GRK50.65550776
88GRK10.65342064
89STK40.65147226
90PAK10.64087121
91WNK40.61972695
92PRKD30.61151754
93CDK20.53956079
94IKBKB0.53809443
95MARK30.53470428
96ILK0.51819934
97STK100.51189988
98FES0.50236828
99INSRR0.50120095
100EIF2AK20.49005703
101EPHA40.47068966
102PIM10.46370886
103PBK0.45900278
104PRKCG0.45735192
105EEF2K0.45519600
106TIE10.44739442
107MAP2K60.44411803
108PRKCQ0.42549982
109OXSR10.39612238
110TEC0.38990121
111RPS6KA50.38673884
112LMTK20.37569464
113STK38L0.36936755
114LRRK20.36501547
115TTN0.35900334
116LYN0.34899824
117MAPK130.34850745
118ABL20.33550897
119TNK20.33382012
120CDK10.33211267
121ADRBK10.31888685
122EPHA20.30506674
123AKT20.29970288
124CSNK1A10.28085644
125DAPK10.27930695
126MAP3K100.27650070
127BTK0.26551493
128PRKCI0.25053860
129YES10.23831385
130PTK2B0.23229203
131PKN20.18960776
132STK240.18674131
133DYRK20.18334495
134CSNK1E0.17793654
135TAOK20.17599388
136PRKDC0.17398887
137KIT0.15296930
138MAP3K50.15159776

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.45920087
2Ribosome_Homo sapiens_hsa030104.39516707
3Proteasome_Homo sapiens_hsa030503.78814253
4Mismatch repair_Homo sapiens_hsa034303.77453324
5RNA polymerase_Homo sapiens_hsa030203.56109136
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40343009
7Spliceosome_Homo sapiens_hsa030403.06582617
8Homologous recombination_Homo sapiens_hsa034402.86616026
9Pyrimidine metabolism_Homo sapiens_hsa002402.85944280
10RNA transport_Homo sapiens_hsa030132.78818545
11Base excision repair_Homo sapiens_hsa034102.69210008
12Nucleotide excision repair_Homo sapiens_hsa034202.59775695
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.29915316
14Parkinsons disease_Homo sapiens_hsa050122.22080981
15Basal transcription factors_Homo sapiens_hsa030222.21326511
16Oxidative phosphorylation_Homo sapiens_hsa001902.13741532
17Huntingtons disease_Homo sapiens_hsa050162.10017881
18Fanconi anemia pathway_Homo sapiens_hsa034602.04822744
19One carbon pool by folate_Homo sapiens_hsa006701.97817279
20RNA degradation_Homo sapiens_hsa030181.89410852
21Cell cycle_Homo sapiens_hsa041101.85277549
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.83840040
23Purine metabolism_Homo sapiens_hsa002301.75149966
24Non-homologous end-joining_Homo sapiens_hsa034501.72728661
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.57773191
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.55525324
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.39931975
28mRNA surveillance pathway_Homo sapiens_hsa030151.34593633
29Pentose phosphate pathway_Homo sapiens_hsa000301.32992723
30Alzheimers disease_Homo sapiens_hsa050101.28633007
31Carbon metabolism_Homo sapiens_hsa012001.23768963
32Biosynthesis of amino acids_Homo sapiens_hsa012301.23503639
33Pyruvate metabolism_Homo sapiens_hsa006201.16717112
34Cardiac muscle contraction_Homo sapiens_hsa042601.16714320
35Fatty acid elongation_Homo sapiens_hsa000621.15033353
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11074935
37Protein export_Homo sapiens_hsa030601.10611020
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09392256
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04239172
40p53 signaling pathway_Homo sapiens_hsa041151.01647651
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94666586
42Epstein-Barr virus infection_Homo sapiens_hsa051690.93567187
43Systemic lupus erythematosus_Homo sapiens_hsa053220.92402718
44Selenocompound metabolism_Homo sapiens_hsa004500.91260346
45Fructose and mannose metabolism_Homo sapiens_hsa000510.90234632
46Sulfur relay system_Homo sapiens_hsa041220.89186538
47Peroxisome_Homo sapiens_hsa041460.88309297
48Asthma_Homo sapiens_hsa053100.87557060
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84881437
50Oocyte meiosis_Homo sapiens_hsa041140.83721881
51Regulation of autophagy_Homo sapiens_hsa041400.81579708
52Phototransduction_Homo sapiens_hsa047440.81268626
53Glutathione metabolism_Homo sapiens_hsa004800.80569127
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77182768
55Folate biosynthesis_Homo sapiens_hsa007900.77130029
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75593443
57Propanoate metabolism_Homo sapiens_hsa006400.73388393
58Butanoate metabolism_Homo sapiens_hsa006500.73356022
59Allograft rejection_Homo sapiens_hsa053300.72383697
60Collecting duct acid secretion_Homo sapiens_hsa049660.66499412
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66328043
62Autoimmune thyroid disease_Homo sapiens_hsa053200.66112430
63Type I diabetes mellitus_Homo sapiens_hsa049400.65877091
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64056529
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64016633
66Vitamin B6 metabolism_Homo sapiens_hsa007500.63684656
67Metabolic pathways_Homo sapiens_hsa011000.61572833
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.61352245
69Graft-versus-host disease_Homo sapiens_hsa053320.60960731
70Herpes simplex infection_Homo sapiens_hsa051680.60337861
71Antigen processing and presentation_Homo sapiens_hsa046120.58470657
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56656473
73Sulfur metabolism_Homo sapiens_hsa009200.52975986
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.49926892
75Viral carcinogenesis_Homo sapiens_hsa052030.48929509
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.48708718
77Linoleic acid metabolism_Homo sapiens_hsa005910.47806707
78N-Glycan biosynthesis_Homo sapiens_hsa005100.46876246
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44144852
80Nitrogen metabolism_Homo sapiens_hsa009100.43512763
81Legionellosis_Homo sapiens_hsa051340.43193845
82Rheumatoid arthritis_Homo sapiens_hsa053230.42312801
83Arachidonic acid metabolism_Homo sapiens_hsa005900.41366519
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41019859
85Galactose metabolism_Homo sapiens_hsa000520.40731193
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40146814
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36622188
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35198319
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33361807
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32705838
91Thyroid cancer_Homo sapiens_hsa052160.32204799
92Tryptophan metabolism_Homo sapiens_hsa003800.31250120
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.30276847
94HTLV-I infection_Homo sapiens_hsa051660.30244091
95Alcoholism_Homo sapiens_hsa050340.27584549
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.27065514
97Arginine and proline metabolism_Homo sapiens_hsa003300.27033242
98Fatty acid metabolism_Homo sapiens_hsa012120.26927475
99Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26321324
100Steroid biosynthesis_Homo sapiens_hsa001000.24377185
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24144106
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23037091
103HIF-1 signaling pathway_Homo sapiens_hsa040660.21127144
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.19630184
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18577206
106Chemical carcinogenesis_Homo sapiens_hsa052040.18275354
107Glucagon signaling pathway_Homo sapiens_hsa049220.18241020
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.15676609
109Hematopoietic cell lineage_Homo sapiens_hsa046400.15506610
110Renin-angiotensin system_Homo sapiens_hsa046140.14693292
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.14448842
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.12748833
113Fatty acid biosynthesis_Homo sapiens_hsa000610.08299731
114Fatty acid degradation_Homo sapiens_hsa000710.07517827
115Phenylalanine metabolism_Homo sapiens_hsa003600.06748784
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03086349
117Primary immunodeficiency_Homo sapiens_hsa05340-0.0990285
118Pathways in cancer_Homo sapiens_hsa05200-0.0947392
119Tyrosine metabolism_Homo sapiens_hsa00350-0.0945745
120TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0841415
121Acute myeloid leukemia_Homo sapiens_hsa05221-0.0770247
122Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0638441
123Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0562772
124SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0427136
125Influenza A_Homo sapiens_hsa05164-0.0406637
126Basal cell carcinoma_Homo sapiens_hsa05217-0.0361932
127Measles_Homo sapiens_hsa05162-0.0348392
128Shigellosis_Homo sapiens_hsa05131-0.0347079
129Fat digestion and absorption_Homo sapiens_hsa04975-0.0305281
130Apoptosis_Homo sapiens_hsa04210-0.0299436
131Small cell lung cancer_Homo sapiens_hsa05222-0.0002235

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