RAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.51390841
2DNA deamination (GO:0045006)6.39978436
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.96967319
4positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.55518647
5antigen processing and presentation via MHC class Ib (GO:0002475)5.14750002
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.88630421
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.88630421
8muscle filament sliding (GO:0030049)4.77665566
9actin-myosin filament sliding (GO:0033275)4.77665566
10viral transcription (GO:0019083)4.65693381
11mast cell activation (GO:0045576)4.55335212
12NADH metabolic process (GO:0006734)4.54028355
13platelet dense granule organization (GO:0060155)4.53910624
14regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.45260903
15translational termination (GO:0006415)4.42896861
16sarcoplasmic reticulum calcium ion transport (GO:0070296)4.35068183
17positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.28329226
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.26709895
19cotranslational protein targeting to membrane (GO:0006613)4.19424019
20lymphoid progenitor cell differentiation (GO:0002320)4.18404072
21regulation of actin filament-based movement (GO:1903115)4.15776311
22regulation of skeletal muscle contraction (GO:0014819)4.14861095
23protein targeting to ER (GO:0045047)4.14293178
24regulation of relaxation of muscle (GO:1901077)4.12489227
25regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.09597302
26negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.09381486
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.08786597
28response to interferon-beta (GO:0035456)4.08426872
29telomere maintenance via semi-conservative replication (GO:0032201)4.07247685
30regulation of cell communication by electrical coupling (GO:0010649)4.00769501
31antigen processing and presentation of endogenous antigen (GO:0019883)4.00720985
32mast cell degranulation (GO:0043303)3.99728024
33mast cell activation involved in immune response (GO:0002279)3.99728024
34protein localization to endoplasmic reticulum (GO:0070972)3.98796491
35ribosomal small subunit biogenesis (GO:0042274)3.92624033
36establishment of protein localization to endoplasmic reticulum (GO:0072599)3.92138739
37regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.90772340
38fucose catabolic process (GO:0019317)3.87139237
39L-fucose metabolic process (GO:0042354)3.87139237
40L-fucose catabolic process (GO:0042355)3.87139237
41translational elongation (GO:0006414)3.86038950
42actin-mediated cell contraction (GO:0070252)3.77919516
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.77222221
44regulation of T cell mediated cytotoxicity (GO:0001914)3.72646632
45defense response to protozoan (GO:0042832)3.60829899
46cellular response to interferon-beta (GO:0035458)3.60324769
47DNA strand elongation involved in DNA replication (GO:0006271)3.60075988
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.59249042
49xenobiotic catabolic process (GO:0042178)3.58456050
50positive regulation of B cell differentiation (GO:0045579)3.57725150
51relaxation of cardiac muscle (GO:0055119)3.57517901
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54815814
53cardiac muscle contraction (GO:0060048)3.50311862
54cellular potassium ion homeostasis (GO:0030007)3.49572684
55negative regulation of phagocytosis (GO:0050765)3.47773257
56DNA strand elongation (GO:0022616)3.46343295
57deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45619190
58response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.40618336
59positive regulation of T cell mediated cytotoxicity (GO:0001916)3.39981667
60relaxation of muscle (GO:0090075)3.39152650
61negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.39058854
62negative regulation of calcium ion transmembrane transport (GO:1903170)3.39058854
63viral life cycle (GO:0019058)3.38823945
64telomere maintenance via recombination (GO:0000722)3.37562351
65regulation of lipoprotein metabolic process (GO:0050746)3.36707904
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.35107046
67response to protozoan (GO:0001562)3.33967746
68cellular protein complex disassembly (GO:0043624)3.32463048
69regulation of B cell differentiation (GO:0045577)3.28560643
70striated muscle contraction (GO:0006941)3.27608468
71sarcomere organization (GO:0045214)3.26639752
72diacylglycerol metabolic process (GO:0046339)3.25673268
73regulation of cardiac muscle cell contraction (GO:0086004)3.25524046
74regulation of B cell receptor signaling pathway (GO:0050855)3.23737914
75respiratory chain complex IV assembly (GO:0008535)3.23028504
76maturation of SSU-rRNA (GO:0030490)3.20901275
77secretory granule organization (GO:0033363)3.19113046
78L-phenylalanine metabolic process (GO:0006558)3.18778146
79erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.18778146
80regulation of striated muscle contraction (GO:0006942)3.18374236
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17446859
82immunoglobulin mediated immune response (GO:0016064)3.12856032
83regulation of metalloenzyme activity (GO:0048552)3.11759846
84neutrophil mediated immunity (GO:0002446)3.11331567
85positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.09911578
86positive regulation of gamma-delta T cell activation (GO:0046645)3.09758542
87cellular response to zinc ion (GO:0071294)3.09499210
88definitive hemopoiesis (GO:0060216)3.03579918
89signal peptide processing (GO:0006465)3.03337443
90sodium ion export (GO:0071436)3.02319433
91regulation of cholesterol esterification (GO:0010872)3.00728927
92polyketide metabolic process (GO:0030638)2.98661234
93doxorubicin metabolic process (GO:0044598)2.98661234
94daunorubicin metabolic process (GO:0044597)2.98661234
95translational initiation (GO:0006413)2.98238378
96angiogenesis involved in wound healing (GO:0060055)2.96593811
97regulation of T cell receptor signaling pathway (GO:0050856)2.96125460
98eosinophil chemotaxis (GO:0048245)2.95968500
99DNA replication initiation (GO:0006270)2.95939042
100creatine metabolic process (GO:0006600)2.93622608
101myofibril assembly (GO:0030239)2.93369824
102carnitine shuttle (GO:0006853)2.92249543
103response to interferon-alpha (GO:0035455)2.91444073
104regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.89965217
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89923673
106telomere maintenance via telomere lengthening (GO:0010833)2.89000773
107response to misfolded protein (GO:0051788)2.88338104
108cardiac myofibril assembly (GO:0055003)2.88298131
109response to muscle activity (GO:0014850)2.87782829
110regulation of necroptotic process (GO:0060544)2.87687928
111protein complex disassembly (GO:0043241)2.87003348
112purine-containing compound salvage (GO:0043101)2.86929868
113endosome to pigment granule transport (GO:0043485)2.86817644
114endosome to melanosome transport (GO:0035646)2.86817644
115regulation of necrotic cell death (GO:0010939)2.86466985
116myeloid leukocyte mediated immunity (GO:0002444)2.83819300
117cell communication by electrical coupling (GO:0010644)2.82479578
118necroptotic process (GO:0070266)2.81210472
119potassium ion import (GO:0010107)2.80984117
120mitotic recombination (GO:0006312)2.80664687
121triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.80474961
122skeletal muscle contraction (GO:0003009)2.80295364
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.79357129
124pseudouridine synthesis (GO:0001522)2.78344570
125cytochrome complex assembly (GO:0017004)2.76785146
126erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.76273367
127L-phenylalanine catabolic process (GO:0006559)2.76273367
128negative regulation of growth of symbiont in host (GO:0044130)2.74971738
129negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.74971738
130modulation of growth of symbiont involved in interaction with host (GO:0044144)2.74971738
131regulation of growth of symbiont in host (GO:0044126)2.74971738
132positive regulation of respiratory burst (GO:0060267)2.74164059
133regulation of calcium ion transmembrane transporter activity (GO:1901019)2.72747637
134regulation of calcium ion transmembrane transport (GO:1903169)2.72747637
135respiratory burst (GO:0045730)2.72315647
136positive regulation of lamellipodium assembly (GO:0010592)2.71787285
137leukocyte degranulation (GO:0043299)2.71515826
138cellular response to type I interferon (GO:0071357)2.70988546
139type I interferon signaling pathway (GO:0060337)2.70988546
140protein targeting to membrane (GO:0006612)2.70432983
141macromolecular complex disassembly (GO:0032984)2.70243132
142glyoxylate metabolic process (GO:0046487)2.70085342
143negative regulation of protein localization to cell surface (GO:2000009)2.69472791
144response to type I interferon (GO:0034340)2.67053169
145regulation of cardiac muscle contraction (GO:0055117)2.66310831
146B cell receptor signaling pathway (GO:0050853)2.66209467
147mature B cell differentiation involved in immune response (GO:0002313)2.65913133
148negative regulation of erythrocyte differentiation (GO:0045647)2.65248146
149response to gravity (GO:0009629)2.65027442
150T cell homeostasis (GO:0043029)2.64926304
151eosinophil migration (GO:0072677)2.64660137
152regulation of the force of heart contraction (GO:0002026)2.63864521
153antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.63822362
154cardiac muscle hypertrophy (GO:0003300)2.61195130
155translation (GO:0006412)2.59960611
156neutrophil activation involved in immune response (GO:0002283)2.59885046
157killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.58494901
158disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.58494901
159regulation of respiratory burst (GO:0060263)2.58046508
160positive regulation of macrophage differentiation (GO:0045651)2.56658193
161fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.56248991
162positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.55843547
163antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.55700132
164ubiquinone biosynthetic process (GO:0006744)2.55191972
165cellular sodium ion homeostasis (GO:0006883)2.54965621
166muscle contraction (GO:0006936)2.54469930
167cell communication involved in cardiac conduction (GO:0086065)2.53761442
168tricarboxylic acid cycle (GO:0006099)2.53620776
169heterotypic cell-cell adhesion (GO:0034113)2.52853574
170negative regulation of muscle contraction (GO:0045932)2.52632826
171potassium ion homeostasis (GO:0055075)2.52180087
172actin filament-based movement (GO:0030048)2.51921839
173heart contraction (GO:0060047)2.50988410
174heart process (GO:0003015)2.50988410
175negative regulation of cation channel activity (GO:2001258)2.47494011
176regulation of voltage-gated calcium channel activity (GO:1901385)2.46274190
177response to mercury ion (GO:0046689)2.45643265
178negative regulation of heart contraction (GO:0045822)2.45635269
179striated muscle hypertrophy (GO:0014897)2.45539012
180detection of calcium ion (GO:0005513)2.42508904
181muscle tissue morphogenesis (GO:0060415)2.42160546
182muscle system process (GO:0003012)2.39655369
183relaxation of smooth muscle (GO:0044557)2.37687671
184regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.36112590
185lipopolysaccharide biosynthetic process (GO:0009103)2.35852127
186fatty acid transmembrane transport (GO:1902001)2.35561582
187positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.34900540
1882-oxoglutarate metabolic process (GO:0006103)2.34700605
189coenzyme catabolic process (GO:0009109)2.34556598
190cardiac muscle tissue morphogenesis (GO:0055008)2.33351636
191quinone biosynthetic process (GO:1901663)2.29846246
192response to epinephrine (GO:0071871)2.27958815
193actomyosin structure organization (GO:0031032)2.27221414
194carnitine transmembrane transport (GO:1902603)2.27185995
195protein heterotetramerization (GO:0051290)2.26433074
196one-carbon compound transport (GO:0019755)2.23732419
197fatty acid elongation (GO:0030497)2.23407542
198galactose metabolic process (GO:0006012)2.23299436
199regulation of integrin-mediated signaling pathway (GO:2001044)2.21415498
200positive regulation of cation channel activity (GO:2001259)2.21323919

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.48338576
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.77671784
3SCL_19346495_ChIP-Seq_HPC-7_Human3.44419961
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.41171280
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35821972
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.30666387
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.27344553
8* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse3.21453896
9* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.17997413
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07568618
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00869517
12FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.95645108
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.93519832
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87266968
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.83507386
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.78638176
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.78405379
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.71465515
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.68225647
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67863652
21* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.66215023
22MYC_18555785_ChIP-Seq_MESCs_Mouse2.63017440
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.61771902
24GATA1_22025678_ChIP-Seq_K562_Human2.47018264
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.45693521
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42922393
27* LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.41510914
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.41188536
29THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.34395472
30RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32875006
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.32073349
32SPI1_23547873_ChIP-Seq_NB4_Human2.31858364
33GABP_17652178_ChIP-ChIP_JURKAT_Human2.31052565
34VDR_21846776_ChIP-Seq_THP-1_Human2.25587109
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.23233105
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.20328356
37ERG_20887958_ChIP-Seq_HPC-7_Mouse2.20078816
38SRY_22984422_ChIP-ChIP_TESTIS_Rat2.16391007
39RXR_22158963_ChIP-Seq_LIVER_Mouse2.15916944
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse2.14207474
41MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12877614
42NOTCH1_21737748_ChIP-Seq_TLL_Human2.12119238
43EST1_17652178_ChIP-ChIP_JURKAT_Human2.11817363
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.06551854
45ESR2_21235772_ChIP-Seq_MCF-7_Human2.01710481
46VDR_23849224_ChIP-Seq_CD4+_Human2.00800318
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.00667426
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.99163139
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.96845873
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.96797937
51LXR_22292898_ChIP-Seq_THP-1_Human1.95915814
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94679107
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.94092433
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.93338887
55MYB_26560356_Chip-Seq_TH2_Human1.91334821
56VDR_24763502_ChIP-Seq_THP-1_Human1.87616746
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85189705
58CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85172676
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.85168723
60FOXP3_21729870_ChIP-Seq_TREG_Human1.81055392
61PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.78381611
62FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.78244804
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.76838199
64RUNX1_22412390_ChIP-Seq_EML_Mouse1.74683784
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.72833271
66* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.72511882
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70787588
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.70111934
69MYC_22102868_ChIP-Seq_BL_Human1.69564139
70EZH2_22144423_ChIP-Seq_EOC_Human1.68172484
71SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66174755
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64059915
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58902534
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58430149
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.58080081
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.54781667
77E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53975580
78MAF_26560356_Chip-Seq_TH1_Human1.52501375
79MYB_26560356_Chip-Seq_TH1_Human1.52388913
80* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.51778037
81* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51383512
82PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.51221411
83CIITA_25753668_ChIP-Seq_RAJI_Human1.50189245
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46794407
85* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44842592
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.43023805
87TBX20_22328084_ChIP-Seq_HEART_Mouse1.43023805
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42271857
89* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41734038
90CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38069406
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37902839
92* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36809082
93* EZH2_27294783_Chip-Seq_ESCs_Mouse1.35286424
94RUNX_20019798_ChIP-Seq_JUKART_Human1.35180594
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35150206
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34390315
97YY1_21170310_ChIP-Seq_MESCs_Mouse1.34164151
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33373739
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32936694
100XRN2_22483619_ChIP-Seq_HELA_Human1.29847602
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29828873
102* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29493176
103NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.28863501
104MYC_19079543_ChIP-ChIP_MESCs_Mouse1.28595210
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28025133
106* RACK7_27058665_Chip-Seq_MCF-7_Human1.27987075
107STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27759141
108* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27576242
109ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26723499
110UTX_26944678_Chip-Seq_JUKART_Human1.26406019
111* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25937940
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.25917414
113CTCF_27219007_Chip-Seq_Bcells_Human1.25536571
114LXR_22158963_ChIP-Seq_LIVER_Mouse1.23999538
115PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23543762
116GABP_19822575_ChIP-Seq_HepG2_Human1.23295536
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.22958943
118DCP1A_22483619_ChIP-Seq_HELA_Human1.22791462
119P68_20966046_ChIP-Seq_HELA_Human1.21961364
120SMC4_20622854_ChIP-Seq_HELA_Human1.20789561
121TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.20670439
122SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20280865
123TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19097894
124EP300_21415370_ChIP-Seq_HL-1_Mouse1.18816916
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18798728
126BCL6_27268052_Chip-Seq_Bcells_Human1.17864286
127SPI1_23127762_ChIP-Seq_K562_Human1.17467365
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16768680
129E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16731172
130BCOR_27268052_Chip-Seq_Bcells_Human1.14575578
131CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10868532
132* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09977769
133CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.09027673
134* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08499008
135SA1_27219007_Chip-Seq_Bcells_Human1.08492742
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.08433043
137JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08393667
138TET1_21451524_ChIP-Seq_MESCs_Mouse1.08134203
139* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07919436
140SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07767500
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07547369
142ELF1_20517297_ChIP-Seq_JURKAT_Human1.07340101
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07102213
144SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06366807
145TTF2_22483619_ChIP-Seq_HELA_Human1.05394774
146SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.05097093
147PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04962659
148EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04643971
149EZH2_18974828_ChIP-Seq_MESCs_Mouse1.04166096
150RNF2_18974828_ChIP-Seq_MESCs_Mouse1.04166096
151STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03086168
152TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02226075
153ELK1_19687146_ChIP-ChIP_HELA_Human1.01814028
154CTCF_20526341_ChIP-Seq_ESCs_Human1.01349459
155SA1_27219007_Chip-Seq_ERYTHROID_Human1.01159696
156TP53_23651856_ChIP-Seq_MEFs_Mouse1.00908855
157GATA3_27048872_Chip-Seq_THYMUS_Human1.00382267
158PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99130157
159SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97881581
160PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97642383
161NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97394915
162EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96918884
163* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95939480
164MAF_26560356_Chip-Seq_TH2_Human0.95930639
165ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95592516
166DROSHA_22980978_ChIP-Seq_HELA_Human0.95463177
167CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95350527
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.95315548
169CLOCK_20551151_ChIP-Seq_293T_Human0.94301460
170EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93948937
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92443515
172* GATA1_19941827_ChIP-Seq_MEL_Mouse0.92411293
173* TET1_21490601_ChIP-Seq_MESCs_Mouse0.92195486
174RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.91407157
175* SOX2_21211035_ChIP-Seq_LN229_Human0.90849322
176MYC_18940864_ChIP-ChIP_HL60_Human0.90841077
177TAF2_19829295_ChIP-Seq_ESCs_Human0.90802533
178KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89922900
179EGR1_19374776_ChIP-ChIP_THP-1_Human0.89306601
180EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89213804
181HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88940154
182* PU_27001747_Chip-Seq_BMDM_Mouse0.88580518
183ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88296089
184E2F1_21310950_ChIP-Seq_MCF-7_Human0.88214658
185TP63_22573176_ChIP-Seq_HFKS_Human0.88208870
186ELK3_25401928_ChIP-Seq_HUVEC_Human0.87952310
187CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87020250
188CTCF_27219007_Chip-Seq_ERYTHROID_Human0.86639521
189OCT4_19829295_ChIP-Seq_ESCs_Human0.85592798
190* RARB_27405468_Chip-Seq_BRAIN_Mouse0.84683784
191CSB_26484114_Chip-Seq_FIBROBLAST_Human0.83559424
192* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82344064
193P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82271461
194IKZF1_21737484_ChIP-ChIP_HCT116_Human0.81173351
195ESR1_21235772_ChIP-Seq_MCF-7_Human0.79896972

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.25165867
2MP0002396_abnormal_hematopoietic_system4.18869178
3MP0000751_myopathy4.17982859
4MP0000749_muscle_degeneration3.31583438
5MP0009785_altered_susceptibility_to3.22447395
6MP0004145_abnormal_muscle_electrophysio3.15296617
7MP0004036_abnormal_muscle_relaxation3.14242952
8MP0005671_abnormal_response_to3.12539087
9MP0000685_abnormal_immune_system3.10896309
10MP0004084_abnormal_cardiac_muscle3.07415779
11MP0005174_abnormal_tail_pigmentation3.05295125
12MP0003646_muscle_fatigue2.83421239
13MP0003763_abnormal_thymus_physiology2.76131972
14MP0002166_altered_tumor_susceptibility2.71864261
15MP0005025_abnormal_response_to2.63588582
16MP0002148_abnormal_hypersensitivity_rea2.61905101
17MP0005670_abnormal_white_adipose2.53978260
18MP0005075_abnormal_melanosome_morpholog2.40927516
19MP0002419_abnormal_innate_immunity2.38204822
20MP0002420_abnormal_adaptive_immunity2.37000354
21MP0009379_abnormal_foot_pigmentation2.35433965
22MP0002837_dystrophic_cardiac_calcinosis2.34729522
23MP0005000_abnormal_immune_tolerance2.34469260
24MP0001819_abnormal_immune_cell2.33236880
25MP0003724_increased_susceptibility_to2.32665450
26MP0005330_cardiomyopathy2.31089399
27MP0001853_heart_inflammation2.29940362
28MP0002006_tumorigenesis2.25654498
29* MP0002723_abnormal_immune_serum2.23670614
30MP0002398_abnormal_bone_marrow2.23094695
31MP0003329_amyloid_beta_deposits2.22046929
32MP0001800_abnormal_humoral_immune2.20621643
33MP0004215_abnormal_myocardial_fiber2.17556256
34MP0002452_abnormal_antigen_presenting2.17472849
35MP0005464_abnormal_platelet_physiology2.17063536
36MP0003436_decreased_susceptibility_to2.08193528
37MP0009840_abnormal_foam_cell2.07411578
38MP0001545_abnormal_hematopoietic_system2.05639945
39MP0005397_hematopoietic_system_phenotyp2.05639945
40MP0005165_increased_susceptibility_to2.03263845
41MP0000716_abnormal_immune_system2.02406238
42MP0004270_analgesia2.01591580
43MP0000015_abnormal_ear_pigmentation2.00498614
44MP0002972_abnormal_cardiac_muscle1.98402698
45MP0002095_abnormal_skin_pigmentation1.94077012
46MP0005620_abnormal_muscle_contractility1.93966671
47MP0004087_abnormal_muscle_fiber1.93574234
48MP0003172_abnormal_lysosome_physiology1.90537963
49MP0004808_abnormal_hematopoietic_stem1.88725558
50MP0010386_abnormal_urinary_bladder1.86608658
51MP0001873_stomach_inflammation1.86117505
52MP0000747_muscle_weakness1.86051071
53MP0001790_abnormal_immune_system1.85837915
54MP0005387_immune_system_phenotype1.85837915
55MP0000689_abnormal_spleen_morphology1.83454296
56MP0003866_abnormal_defecation1.83246752
57MP0000750_abnormal_muscle_regeneration1.81762009
58MP0002722_abnormal_immune_system1.78782030
59MP0008260_abnormal_autophagy1.78142547
60MP0000490_abnormal_crypts_of1.77483953
61MP0002429_abnormal_blood_cell1.76033322
62MP0002332_abnormal_exercise_endurance1.74647421
63MP0002106_abnormal_muscle_physiology1.74244761
64MP0010155_abnormal_intestine_physiology1.66625807
65MP0000465_gastrointestinal_hemorrhage1.66096651
66MP0001986_abnormal_taste_sensitivity1.65102393
67MP0000920_abnormal_myelination1.64636805
68MP0009780_abnormal_chondrocyte_physiolo1.61908256
69MP0000759_abnormal_skeletal_muscle1.61793086
70MP0009333_abnormal_splenocyte_physiolog1.61673254
71MP0002405_respiratory_system_inflammati1.61636983
72MP0003137_abnormal_impulse_conducting1.60590173
73MP0003690_abnormal_glial_cell1.57542713
74MP0005451_abnormal_body_composition1.56243943
75MP0004484_altered_response_of1.50229239
76MP0005369_muscle_phenotype1.49458039
77MP0005409_darkened_coat_color1.49008206
78MP0005166_decreased_susceptibility_to1.48788759
79MP0001845_abnormal_inflammatory_respons1.44452631
80MP0006138_congestive_heart_failure1.44364835
81MP0002269_muscular_atrophy1.42908523
82MP0000703_abnormal_thymus_morphology1.42269768
83MP0004233_abnormal_muscle_weight1.42126350
84MP0008775_abnormal_heart_ventricle1.41352146
85MP0003011_delayed_dark_adaptation1.38719647
86MP0008875_abnormal_xenobiotic_pharmacok1.37207373
87MP0000604_amyloidosis1.35389964
88MP0002734_abnormal_mechanical_nocicepti1.32903145
89MP0010094_abnormal_chromosome_stability1.28438091
90MP0004147_increased_porphyrin_level1.26534882
91MP0005360_urolithiasis1.25650220
92MP0006292_abnormal_olfactory_placode1.21974196
93MP0008007_abnormal_cellular_replicative1.21669321
94MP0001188_hyperpigmentation1.21418064
95MP0002064_seizures1.20572753
96* MP0008469_abnormal_protein_level1.20292166
97MP0003045_fibrosis1.19606761
98MP0003693_abnormal_embryo_hatching1.18585066
99MP0005365_abnormal_bile_salt1.17662127
100MP0003075_altered_response_to1.16962957
101MP0001486_abnormal_startle_reflex1.15240813
102MP0001544_abnormal_cardiovascular_syste1.15111837
103MP0005385_cardiovascular_system_phenoty1.15111837
104MP0000858_altered_metastatic_potential1.12713211
105MP0008569_lethality_at_weaning1.12074245
106MP0001970_abnormal_pain_threshold1.11157240
107MP0008058_abnormal_DNA_repair1.10433612
108MP0003183_abnormal_peptide_metabolism1.10184544
109MP0006036_abnormal_mitochondrial_physio1.09887644
110MP0009745_abnormal_behavioral_response1.09501960
111MP0004130_abnormal_muscle_cell1.09441610
112MP0002736_abnormal_nociception_after1.08717530
113MP0000343_altered_response_to1.08131459
114MP0003635_abnormal_synaptic_transmissio1.05318685
115MP0008057_abnormal_DNA_replication1.04749066
116MP0001984_abnormal_olfaction1.04184708
117MP0003880_abnormal_central_pattern1.02416380
118MP0001502_abnormal_circadian_rhythm1.02389845
119MP0010630_abnormal_cardiac_muscle1.01780727
120MP0005167_abnormal_blood-brain_barrier1.01196346
121MP0000372_irregular_coat_pigmentation1.00904220
122MP0002019_abnormal_tumor_incidence1.00395318
123MP0001905_abnormal_dopamine_level0.99639713
124MP0002735_abnormal_chemical_nociception0.98492831
125MP0002272_abnormal_nervous_system0.96878558
126MP0005379_endocrine/exocrine_gland_phen0.95156347
127MP0001958_emphysema0.94700740
128MP0001663_abnormal_digestive_system0.94045368
129MP0002877_abnormal_melanocyte_morpholog0.93040370
130MP0000462_abnormal_digestive_system0.89548268
131MP0000538_abnormal_urinary_bladder0.88664541
132MP0002572_abnormal_emotion/affect_behav0.88316185
133MP0000681_abnormal_thyroid_gland0.88074134
134MP0002132_abnormal_respiratory_system0.87825398
135MP0004085_abnormal_heartbeat0.87562847
136MP0003634_abnormal_glial_cell0.86856911
137MP0002733_abnormal_thermal_nociception0.86397331
138MP0001968_abnormal_touch/_nociception0.84854470
139MP0002063_abnormal_learning/memory/cond0.84695944
140MP0003186_abnormal_redox_activity0.84380737
141MP0003279_aneurysm0.83286697
142MP0003879_abnormal_hair_cell0.82849625
143MP0005310_abnormal_salivary_gland0.81356120
144MP0002909_abnormal_adrenal_gland0.80696131
145MP0003656_abnormal_erythrocyte_physiolo0.78979381
146MP0001533_abnormal_skeleton_physiology0.78787057
147MP0001661_extended_life_span0.78431230
148MP0003303_peritoneal_inflammation0.78040865
149MP0000013_abnormal_adipose_tissue0.75871603
150MP0001529_abnormal_vocalization0.75668359
151MP0009764_decreased_sensitivity_to0.75194813
152MP0002108_abnormal_muscle_morphology0.74680625
153MP0005386_behavior/neurological_phenoty0.74521509
154MP0004924_abnormal_behavior0.74521509
155MP0000249_abnormal_blood_vessel0.74397088
156MP0002075_abnormal_coat/hair_pigmentati0.73932653
157MP0002933_joint_inflammation0.73430341
158MP0005332_abnormal_amino_acid0.72601945
159MP0002822_catalepsy0.70238756
160MP0005058_abnormal_lysosome_morphology0.70027476
161MP0009046_muscle_twitch0.67727295
162MP0002876_abnormal_thyroid_physiology0.67524514
163MP0003638_abnormal_response/metabolism_0.67166868
164MP0005666_abnormal_adipose_tissue0.66394181
165MP0004947_skin_inflammation0.65743388
166MP0001764_abnormal_homeostasis0.65677102
167MP0004957_abnormal_blastocyst_morpholog0.65644652
168MP0004510_myositis0.63515679
169MP0005584_abnormal_enzyme/coenzyme_acti0.63419854
170MP0000371_diluted_coat_color0.63104530
171MP0004859_abnormal_synaptic_plasticity0.61377989
172MP0000313_abnormal_cell_death0.60189955
173MP0003077_abnormal_cell_cycle0.57710548
174MP0005423_abnormal_somatic_nervous0.56983609
175MP0006082_CNS_inflammation0.55787395
176MP0002638_abnormal_pupillary_reflex0.55652878
177MP0004381_abnormal_hair_follicle0.55557035
178MP0009763_increased_sensitivity_to0.55519511
179MP0001851_eye_inflammation0.55165848
180MP0006054_spinal_hemorrhage0.54942652
181MP0003191_abnormal_cellular_cholesterol0.54603383
182MP0008874_decreased_physiological_sensi0.54494547

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)5.79962655
2Thrombocytosis (HP:0001894)5.44135915
3Exercise-induced myalgia (HP:0003738)4.88043514
4Muscle fiber inclusion bodies (HP:0100299)4.73123784
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.67976146
6Nemaline bodies (HP:0003798)4.53664780
7Hyporeflexia of lower limbs (HP:0002600)4.52305488
8Recurrent gram-negative bacterial infections (HP:0005420)4.42559301
9Aplastic anemia (HP:0001915)4.42483680
10Abnormal number of erythroid precursors (HP:0012131)4.36930130
11Myositis (HP:0100614)4.36204877
12IgM deficiency (HP:0002850)4.32090005
13Abnormality of cells of the erythroid lineage (HP:0012130)4.22792760
14Sudden death (HP:0001699)4.22017390
15Chronic otitis media (HP:0000389)4.18950453
16Type 1 muscle fiber predominance (HP:0003803)4.12416332
17Muscle fiber splitting (HP:0003555)4.06764197
18Distal lower limb muscle weakness (HP:0009053)4.03322406
19Reduced antithrombin III activity (HP:0001976)4.02374777
20Recurrent abscess formation (HP:0002722)3.97583643
21Type I transferrin isoform profile (HP:0003642)3.78277602
22Abnormality of the calf musculature (HP:0001430)3.75127870
23Rhabdomyolysis (HP:0003201)3.71844451
24Reticulocytopenia (HP:0001896)3.64204606
25Exercise-induced muscle cramps (HP:0003710)3.62309144
26Atrioventricular block (HP:0001678)3.60124930
27Recurrent bacterial skin infections (HP:0005406)3.56099380
28Ventricular tachycardia (HP:0004756)3.55315776
29Increased variability in muscle fiber diameter (HP:0003557)3.54597918
30Abnormal atrioventricular conduction (HP:0005150)3.52720735
31Heart block (HP:0012722)3.49667701
32Centrally nucleated skeletal muscle fibers (HP:0003687)3.48494465
33Abnormality of skeletal muscle fiber size (HP:0012084)3.45386843
34Bundle branch block (HP:0011710)3.44814193
35EMG: myopathic abnormalities (HP:0003458)3.39926325
36Muscle hypertrophy of the lower extremities (HP:0008968)3.36637828
37Periodontitis (HP:0000704)3.27942712
38Calf muscle hypertrophy (HP:0008981)3.25919720
39B lymphocytopenia (HP:0010976)3.23632321
40Abnormality of B cell number (HP:0010975)3.23632321
41Recurrent bronchitis (HP:0002837)3.21880043
42Panhypogammaglobulinemia (HP:0003139)3.19386919
43Abnormality of T cell physiology (HP:0011840)3.09476830
44Petechiae (HP:0000967)3.04701019
45Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.00966687
46Abnormal protein N-linked glycosylation (HP:0012347)3.00966687
47Abnormal protein glycosylation (HP:0012346)3.00966687
48Abnormal glycosylation (HP:0012345)3.00966687
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.00607143
50Ventricular arrhythmia (HP:0004308)2.97040667
51Neck muscle weakness (HP:0000467)2.93959886
52Abnormality of binocular vision (HP:0011514)2.93723270
53Diplopia (HP:0000651)2.93723270
54Hypoplasia of the thymus (HP:0000778)2.93026849
55Asymmetric septal hypertrophy (HP:0001670)2.92905303
56Myoglobinuria (HP:0002913)2.91078754
57Bulbar palsy (HP:0001283)2.84526870
58IgG deficiency (HP:0004315)2.79687626
59Acute lymphatic leukemia (HP:0006721)2.78665934
60Hepatocellular necrosis (HP:0001404)2.77890832
61Meningitis (HP:0001287)2.76766523
62Myopathic facies (HP:0002058)2.75466554
63Hypoproteinemia (HP:0003075)2.70621619
64Recurrent skin infections (HP:0001581)2.67200673
65Albinism (HP:0001022)2.66167106
66Abnormality of T cells (HP:0002843)2.65661821
67Type 2 muscle fiber atrophy (HP:0003554)2.63724391
68Areflexia of lower limbs (HP:0002522)2.63646483
69Mediastinal lymphadenopathy (HP:0100721)2.63458401
70Poikiloderma (HP:0001029)2.62489931
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61522699
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61522699
73Thyroiditis (HP:0100646)2.60731112
74Dilated cardiomyopathy (HP:0001644)2.57954032
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.51697076
76Muscle fiber atrophy (HP:0100295)2.51657727
77Recurrent fungal infections (HP:0002841)2.51572197
78Abnormality of the prostate (HP:0008775)2.51300571
79Pallor (HP:0000980)2.49391593
80Abnormality of macrophages (HP:0004311)2.49182195
81EMG: neuropathic changes (HP:0003445)2.48448143
82Severe combined immunodeficiency (HP:0004430)2.47425959
83Lipoatrophy (HP:0100578)2.47372349
84Abnormality of the columella (HP:0009929)2.46298299
85Eczematoid dermatitis (HP:0000976)2.46111179
86Hepatic necrosis (HP:0002605)2.45276710
87Exertional dyspnea (HP:0002875)2.45127994
88Obstructive lung disease (HP:0006536)2.44951852
89Chronic obstructive pulmonary disease (HP:0006510)2.44951852
90Recurrent viral infections (HP:0004429)2.44948901
91Increased connective tissue (HP:0009025)2.43260312
92Increased intramyocellular lipid droplets (HP:0012240)2.42876745
93Chronic mucocutaneous candidiasis (HP:0002728)2.42620552
94Recurrent cutaneous fungal infections (HP:0011370)2.42620552
95Increased hepatocellular lipid droplets (HP:0006565)2.42361373
96Abnormality of the foot musculature (HP:0001436)2.41564858
97Prolonged bleeding time (HP:0003010)2.39742264
98Abnormality of the Achilles tendon (HP:0005109)2.39184779
99Foot dorsiflexor weakness (HP:0009027)2.38359626
100Pancytopenia (HP:0001876)2.35779140
101Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33652165
102Distal arthrogryposis (HP:0005684)2.31657053
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.31579044
104Tetraplegia (HP:0002445)2.31526107
105Hypergammaglobulinemia (HP:0010702)2.31235613
106Myokymia (HP:0002411)2.30584949
107Rimmed vacuoles (HP:0003805)2.30441555
108Axonal loss (HP:0003447)2.30069339
109Achilles tendon contracture (HP:0001771)2.29630645
110Syncope (HP:0001279)2.28205674
111Macrocytic anemia (HP:0001972)2.27741861
112Nasal polyposis (HP:0100582)2.25907908
113Mitochondrial inheritance (HP:0001427)2.24690354
114Epistaxis (HP:0000421)2.24258146
115Atrial fibrillation (HP:0005110)2.22867720
116Supraventricular tachycardia (HP:0004755)2.22277285
117Nasal speech (HP:0001611)2.21501035
118Abnormal delayed hypersensitivity skin test (HP:0002963)2.21357495
119Gingivitis (HP:0000230)2.21344148
120Systemic lupus erythematosus (HP:0002725)2.21097504
121Lymphoma (HP:0002665)2.20785176
122Abnormal mitochondria in muscle tissue (HP:0008316)2.20528173
123Primary atrial arrhythmia (HP:0001692)2.20067415
124Round ear (HP:0100830)2.19789460
125Renal Fanconi syndrome (HP:0001994)2.17920671
126Severe visual impairment (HP:0001141)2.17388281
127Acute necrotizing encephalopathy (HP:0006965)2.16868012
128Neurofibrillary tangles (HP:0002185)2.15925407
129Supraventricular arrhythmia (HP:0005115)2.15411376
130Lymphopenia (HP:0001888)2.15363361
131Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14645861
132Vacuolated lymphocytes (HP:0001922)2.13953506
1333-Methylglutaconic aciduria (HP:0003535)2.13091221
134Orchitis (HP:0100796)2.12874425
135Increased muscle lipid content (HP:0009058)2.12372832
136Chronic sinusitis (HP:0011109)2.11166300
137Abnormality of eosinophils (HP:0001879)2.11064066
138Subaortic stenosis (HP:0001682)2.10713201
139Abnormality of the left ventricular outflow tract (HP:0011103)2.10713201
140Amyloidosis (HP:0011034)2.10675953
141Agammaglobulinemia (HP:0004432)2.10432594
142Erythema (HP:0010783)2.10346390
143Papilledema (HP:0001085)2.09530112
144Weak cry (HP:0001612)2.08970763
145Abnormality of the nasal mucosa (HP:0000433)2.08527569
146Lipid accumulation in hepatocytes (HP:0006561)2.07895193
147Pulmonary fibrosis (HP:0002206)2.06430386
148Progressive macrocephaly (HP:0004481)2.05330429
149Abnormality of cells of the lymphoid lineage (HP:0012140)2.05273515
150Hypothermia (HP:0002045)2.05081749
151Muscle stiffness (HP:0003552)2.04712439
152Granulocytopenia (HP:0001913)2.03674593
153Abnormality of DNA repair (HP:0003254)2.02750384
154Myotonia (HP:0002486)2.02531270
155Neutropenia (HP:0001875)2.02526583
156Basal ganglia calcification (HP:0002135)2.00725230
157Gowers sign (HP:0003391)2.00110331
15811 pairs of ribs (HP:0000878)2.00100857
159Hemiplegia (HP:0002301)1.99250526
160Impaired platelet aggregation (HP:0003540)1.97843770
161Abnormal platelet function (HP:0011869)1.97843770
162Chest pain (HP:0100749)1.97025147
163Increased CSF lactate (HP:0002490)1.96384948
164Vasculitis (HP:0002633)1.96370000
165Limb-girdle muscle atrophy (HP:0003797)1.94977143
166Large eyes (HP:0001090)1.94458491
167Acute myeloid leukemia (HP:0004808)1.93599321
168Hyperalaninemia (HP:0003348)1.93439471
169Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93439471
170Abnormality of alanine metabolism (HP:0010916)1.93439471
171Distal lower limb amyotrophy (HP:0008944)1.93263259
172Interstitial pulmonary disease (HP:0006530)1.92918490
173Acute encephalopathy (HP:0006846)1.90530586
174Right ventricular cardiomyopathy (HP:0011663)1.88424213
175Abnormal pupillary function (HP:0007686)1.88307592
176Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.87857824
177Nonprogressive disorder (HP:0003680)1.87534582
178Mildly elevated creatine phosphokinase (HP:0008180)1.85645544
179Ventricular fibrillation (HP:0001663)1.84573554
180Complement deficiency (HP:0004431)1.82532764
181Scapular winging (HP:0003691)1.82324796
182Ulnar deviation of the wrist (HP:0003049)1.81728492
183Abnormality of fatty-acid metabolism (HP:0004359)1.79484421
184Ankle clonus (HP:0011448)1.79432291
185Joint hemorrhage (HP:0005261)1.78167933
186Abnormality of the tricuspid valve (HP:0001702)1.78061897
187Chronic bronchitis (HP:0004469)1.77692407
188Difficulty climbing stairs (HP:0003551)1.74496443
189Sparse scalp hair (HP:0002209)1.73082170
190Deep venous thrombosis (HP:0002625)1.72595004
191Bradycardia (HP:0001662)1.72116135
192Fetal akinesia sequence (HP:0001989)1.71617624
193Abnormality of the intervertebral disk (HP:0005108)1.70009218
194Ragged-red muscle fibers (HP:0003200)1.69519023
195Frequent falls (HP:0002359)1.68902091
196Spinal rigidity (HP:0003306)1.68608781

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.93955117
2KIT3.57230788
3STK163.44842186
4FLT33.41218218
5OBSCN3.35272341
6TTN3.27983790
7MAP3K123.26446809
8PHKG13.25866135
9PHKG23.25866135
10PBK3.13071536
11TEC2.84629428
12MAP4K12.80454645
13PRKCH2.77755100
14CDK192.51665158
15LMTK22.40875329
16RIPK42.39880577
17CAMKK22.34279733
18LIMK12.20189620
19NME22.18648198
20IRAK42.18089637
21MUSK2.09708283
22PIM22.08203619
23TESK12.02639851
24BTK1.99776440
25NTRK31.97918474
26ICK1.96969125
27CSF1R1.95595684
28EIF2AK31.89355638
29CAMK2G1.81834282
30FES1.80192667
31WEE11.78988326
32SCYL21.77166944
33ZAP701.74858130
34SYK1.69568520
35BLK1.69064635
36TXK1.69016163
37TBK11.59596677
38PRKD31.57652073
39PDK21.55908220
40EPHA21.54722327
41VRK11.51296996
42DAPK11.43530546
43KDR1.40661407
44MST1R1.38753909
45MAP2K31.36493848
46ADRBK21.34463590
47IKBKE1.31294939
48TYRO31.30959301
49CAMK2D1.28776182
50EEF2K1.28109826
51CAMK2B1.24954279
52EPHA31.22713036
53MYLK1.22370022
54EPHB11.21840548
55EPHA41.20525946
56LYN1.11617685
57ACVR1B1.11384898
58DAPK31.10545919
59JAK31.10217430
60DMPK1.05980720
61NTRK11.03634562
62TYK21.03620658
63MARK11.03547952
64EIF2AK11.03011433
65BRSK21.02737795
66TAOK31.02439138
67DAPK21.01897713
68TESK20.99662448
69MAP2K70.98444544
70CCNB10.98169699
71PINK10.97294272
72CAMK2A0.96356369
73RAF10.96183167
74NLK0.95845284
75CAMK10.95177320
76LCK0.94313838
77MATK0.93342189
78TNK20.90762176
79ROCK10.89897555
80PKN10.86474306
81MKNK20.86176998
82CDK80.85875403
83TGFBR10.85203084
84DYRK30.85135742
85RIPK10.84976722
86MAPKAPK50.84692769
87MAPKAPK30.83892907
88TRIB30.82337322
89VRK20.81153672
90FER0.80592641
91CAMKK10.78399171
92GRK50.77195312
93PRKD10.76770674
94GRK60.76487942
95RPS6KB20.76166023
96MKNK10.74851803
97PAK60.74139180
98PDPK10.73995688
99IRAK30.72391490
100BCKDK0.71608309
101MAP3K30.70595556
102LRRK20.69174055
103ROCK20.66213168
104RET0.65415575
105CDC70.63282690
106PDK10.63175809
107IKBKB0.62747725
108MAP3K130.62343445
109MAP3K60.61864604
110SIK30.61450237
111MAP2K10.60779799
112HCK0.59494362
113MAPK40.59178377
114RPS6KA20.58914777
115ERN10.58608325
116PIK3CG0.58127343
117ITK0.56706902
118ARAF0.55624059
119MAP3K10.55045284
120CLK10.54595217
121MET0.53323187
122MAP3K20.52303681
123PAK30.50893475
124MAP3K110.50158297
125ILK0.48440503
126YES10.48387279
127PIK3CA0.47989926
128KSR20.47913307
129ATR0.45554903
130CDK70.45115602
131MINK10.44773546
132TLK10.44319394
133PRKACA0.43535682
134PRPF4B0.43516148
135ADRBK10.43479123
136PIM10.43257988
137BUB10.43190821
138AKT20.42254242
139PRKG20.42050914
140STK380.41663253
141MAPK150.41599727
142PTK2B0.41596257
143BRSK10.40481698
144EIF2AK20.38878566
145PRKCQ0.38581752
146JAK10.38525653
147ERBB40.38376165
148CSK0.37789099
149GSK3A0.37699430
150MAP2K60.37463527
151SRC0.36167008
152PRKACG0.35049952
153GRK70.33898750
154PRKCA0.33763836
155BMPR1B0.32489040
156PRKCD0.32022583
157NME10.30221929
158PASK0.28392487
159TGFBR20.27640467
160MAP3K140.27166672
161RPS6KA60.26204242
162ABL20.25055454
163TAOK20.24228368
164MAPK110.24048510
165PAK40.23902730
166MAPK120.23494722
167MAP3K70.23305975

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52594141
2Ribosome_Homo sapiens_hsa030104.44475604
3Primary immunodeficiency_Homo sapiens_hsa053403.10380795
4Mismatch repair_Homo sapiens_hsa034303.10044947
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.02614856
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.86667267
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.60283893
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.52023073
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42783077
10Base excision repair_Homo sapiens_hsa034102.38253119
11Protein export_Homo sapiens_hsa030602.36966223
12Homologous recombination_Homo sapiens_hsa034402.36071764
13Non-homologous end-joining_Homo sapiens_hsa034502.31553269
14Proteasome_Homo sapiens_hsa030502.28752730
15Cardiac muscle contraction_Homo sapiens_hsa042602.26803126
16Complement and coagulation cascades_Homo sapiens_hsa046102.09279339
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06515482
18Pyrimidine metabolism_Homo sapiens_hsa002402.04951376
19Arginine and proline metabolism_Homo sapiens_hsa003302.03920584
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.98837208
21Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97308580
22Dilated cardiomyopathy_Homo sapiens_hsa054141.95856995
23Nucleotide excision repair_Homo sapiens_hsa034201.91899493
24Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.89207955
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88666912
26RNA polymerase_Homo sapiens_hsa030201.87773874
27Fatty acid elongation_Homo sapiens_hsa000621.81798871
28Other glycan degradation_Homo sapiens_hsa005111.75479627
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.68978355
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68724223
31Prion diseases_Homo sapiens_hsa050201.67141912
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64950402
33Leishmaniasis_Homo sapiens_hsa051401.64020491
34Arginine biosynthesis_Homo sapiens_hsa002201.63521720
35Phenylalanine metabolism_Homo sapiens_hsa003601.63411653
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.57748100
37N-Glycan biosynthesis_Homo sapiens_hsa005101.57719971
38Hematopoietic cell lineage_Homo sapiens_hsa046401.57657834
39Spliceosome_Homo sapiens_hsa030401.56994875
40Carbon metabolism_Homo sapiens_hsa012001.55822855
41Viral myocarditis_Homo sapiens_hsa054161.52120583
42Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.51383341
43Sulfur relay system_Homo sapiens_hsa041221.45055667
44Pyruvate metabolism_Homo sapiens_hsa006201.43816218
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43596676
46Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42459674
47Antigen processing and presentation_Homo sapiens_hsa046121.42262755
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.41157634
49Measles_Homo sapiens_hsa051621.38760784
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.35595170
51Pentose phosphate pathway_Homo sapiens_hsa000301.35493804
52Histidine metabolism_Homo sapiens_hsa003401.31123447
53Biosynthesis of amino acids_Homo sapiens_hsa012301.30912621
54Herpes simplex infection_Homo sapiens_hsa051681.30811807
55Staphylococcus aureus infection_Homo sapiens_hsa051501.30003150
56Purine metabolism_Homo sapiens_hsa002301.28167355
57Bile secretion_Homo sapiens_hsa049761.24909011
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20402022
59Chemical carcinogenesis_Homo sapiens_hsa052041.17453701
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16815270
61B cell receptor signaling pathway_Homo sapiens_hsa046621.15354681
62Allograft rejection_Homo sapiens_hsa053301.14250612
63Linoleic acid metabolism_Homo sapiens_hsa005911.13087386
64Synaptic vesicle cycle_Homo sapiens_hsa047211.12661426
65* Vascular smooth muscle contraction_Homo sapiens_hsa042701.12468970
66PPAR signaling pathway_Homo sapiens_hsa033201.10192884
67RNA degradation_Homo sapiens_hsa030181.09785777
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09762126
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08481576
70Salivary secretion_Homo sapiens_hsa049701.07094093
71Fatty acid degradation_Homo sapiens_hsa000711.05818973
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05777744
73Parkinsons disease_Homo sapiens_hsa050121.04410189
74Glutathione metabolism_Homo sapiens_hsa004801.03510773
75Arachidonic acid metabolism_Homo sapiens_hsa005901.01831326
76Legionellosis_Homo sapiens_hsa051341.00410512
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.99899439
78beta-Alanine metabolism_Homo sapiens_hsa004100.98603943
79Pertussis_Homo sapiens_hsa051330.98452778
80Oxidative phosphorylation_Homo sapiens_hsa001900.97725672
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97118753
82Fanconi anemia pathway_Homo sapiens_hsa034600.94939804
83Osteoclast differentiation_Homo sapiens_hsa043800.94150474
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91352602
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.90935273
86Insulin secretion_Homo sapiens_hsa049110.90242130
87Tyrosine metabolism_Homo sapiens_hsa003500.89952170
88Pancreatic secretion_Homo sapiens_hsa049720.88587823
89Shigellosis_Homo sapiens_hsa051310.88049100
90Fatty acid metabolism_Homo sapiens_hsa012120.88040938
91Circadian entrainment_Homo sapiens_hsa047130.87419026
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86618035
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86025079
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85502099
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.84417452
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82899564
97Fructose and mannose metabolism_Homo sapiens_hsa000510.82700043
98Tuberculosis_Homo sapiens_hsa051520.82286805
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80978942
100Acute myeloid leukemia_Homo sapiens_hsa052210.80956817
101Peroxisome_Homo sapiens_hsa041460.80891913
102Asthma_Homo sapiens_hsa053100.80889368
103Glycerolipid metabolism_Homo sapiens_hsa005610.79586627
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77975751
105Fat digestion and absorption_Homo sapiens_hsa049750.77736897
106Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75535192
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.73905361
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72815432
109Galactose metabolism_Homo sapiens_hsa000520.72662535
110Folate biosynthesis_Homo sapiens_hsa007900.72086467
111Alzheimers disease_Homo sapiens_hsa050100.71848792
112Gastric acid secretion_Homo sapiens_hsa049710.71512003
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70848411
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70726331
115African trypanosomiasis_Homo sapiens_hsa051430.70304373
116Influenza A_Homo sapiens_hsa051640.69969420
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.69941655
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68922856
119Thyroid cancer_Homo sapiens_hsa052160.68406545
120Amphetamine addiction_Homo sapiens_hsa050310.67972667
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67321845
122Renin secretion_Homo sapiens_hsa049240.67011425
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66351829
124T cell receptor signaling pathway_Homo sapiens_hsa046600.64663618
125Amoebiasis_Homo sapiens_hsa051460.63283664
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62712952
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62697500
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62570112
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62567347
130Salmonella infection_Homo sapiens_hsa051320.61674010
131Rheumatoid arthritis_Homo sapiens_hsa053230.60163683
132Platelet activation_Homo sapiens_hsa046110.59600535
133Huntingtons disease_Homo sapiens_hsa050160.59503145
134Glucagon signaling pathway_Homo sapiens_hsa049220.59355366
135GABAergic synapse_Homo sapiens_hsa047270.58952698
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58709529
137Malaria_Homo sapiens_hsa051440.58283658
138Mineral absorption_Homo sapiens_hsa049780.58169829
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57778360
140Tryptophan metabolism_Homo sapiens_hsa003800.57193513
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55890652
142Renin-angiotensin system_Homo sapiens_hsa046140.55740088
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54836568
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53624558
145Hepatitis B_Homo sapiens_hsa051610.53554840
146Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53269644
147Propanoate metabolism_Homo sapiens_hsa006400.52035996
148Autoimmune thyroid disease_Homo sapiens_hsa053200.51778332
149Oxytocin signaling pathway_Homo sapiens_hsa049210.51638199
150Cell cycle_Homo sapiens_hsa041100.50545030
151Type I diabetes mellitus_Homo sapiens_hsa049400.46698016
152Basal transcription factors_Homo sapiens_hsa030220.43959473
153Systemic lupus erythematosus_Homo sapiens_hsa053220.43449192
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43079379
155Steroid hormone biosynthesis_Homo sapiens_hsa001400.43064355
156Epstein-Barr virus infection_Homo sapiens_hsa051690.42579246
157Toxoplasmosis_Homo sapiens_hsa051450.41987164
158Glutamatergic synapse_Homo sapiens_hsa047240.41705821
159Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.41580181
160Lysosome_Homo sapiens_hsa041420.41394852
161Apoptosis_Homo sapiens_hsa042100.41208531
162Chemokine signaling pathway_Homo sapiens_hsa040620.41116096
163Butanoate metabolism_Homo sapiens_hsa006500.40551220
164Starch and sucrose metabolism_Homo sapiens_hsa005000.40439233
165Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39340219
166Retinol metabolism_Homo sapiens_hsa008300.38419265
167Cholinergic synapse_Homo sapiens_hsa047250.37858178
168Insulin signaling pathway_Homo sapiens_hsa049100.37846370
169Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36864957
170Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36036757
171RNA transport_Homo sapiens_hsa030130.35650113
172Calcium signaling pathway_Homo sapiens_hsa040200.33236441
173p53 signaling pathway_Homo sapiens_hsa041150.33167966
174Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28355486
175Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26985063
176Nicotine addiction_Homo sapiens_hsa050330.24587431
177Metabolic pathways_Homo sapiens_hsa011000.22605399
178Alcoholism_Homo sapiens_hsa050340.20865550
179Long-term potentiation_Homo sapiens_hsa047200.20330952
180Cyanoamino acid metabolism_Homo sapiens_hsa004600.19899592
181Leukocyte transendothelial migration_Homo sapiens_hsa046700.18398841
182Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17908877
183Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16775892

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