RALGPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.38139061
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11903526
3locomotory exploration behavior (GO:0035641)5.08601678
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.05356023
5synaptic vesicle maturation (GO:0016188)4.99492952
6vocalization behavior (GO:0071625)4.93367711
7nucleobase catabolic process (GO:0046113)4.85597408
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82578844
9neuron cell-cell adhesion (GO:0007158)4.81516705
10synaptic vesicle exocytosis (GO:0016079)4.67474294
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.59751447
12regulation of synaptic vesicle exocytosis (GO:2000300)4.41784835
13glutamate secretion (GO:0014047)4.36621564
14protein localization to synapse (GO:0035418)4.35465201
15dendritic spine morphogenesis (GO:0060997)4.35280481
16regulation of glutamate receptor signaling pathway (GO:1900449)4.34910528
17layer formation in cerebral cortex (GO:0021819)4.25945385
18neuron recognition (GO:0008038)4.10547721
19synaptic transmission, glutamatergic (GO:0035249)4.08356160
20glutamate receptor signaling pathway (GO:0007215)4.06063199
21establishment of mitochondrion localization (GO:0051654)3.97913266
22regulation of synaptic vesicle transport (GO:1902803)3.97827880
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.91154390
24exploration behavior (GO:0035640)3.88699023
25regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.86600963
26regulation of neuronal synaptic plasticity (GO:0048168)3.81410517
27neuronal action potential propagation (GO:0019227)3.79872657
28axonal fasciculation (GO:0007413)3.78794333
29neurotransmitter secretion (GO:0007269)3.78199281
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76537440
31neuron-neuron synaptic transmission (GO:0007270)3.75515146
32dendrite morphogenesis (GO:0048813)3.73988366
33response to pheromone (GO:0019236)3.66754891
34regulation of synapse structural plasticity (GO:0051823)3.65027240
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.64511065
36long-term memory (GO:0007616)3.57374648
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.57264436
38neurotransmitter-gated ion channel clustering (GO:0072578)3.56888457
39presynaptic membrane assembly (GO:0097105)3.56592961
40synaptic vesicle endocytosis (GO:0048488)3.53008839
41cerebellar Purkinje cell differentiation (GO:0021702)3.52522524
42transmission of nerve impulse (GO:0019226)3.51950913
43presynaptic membrane organization (GO:0097090)3.48356900
44cerebellar granule cell differentiation (GO:0021707)3.47181115
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.46686448
46gamma-aminobutyric acid transport (GO:0015812)3.46384717
47positive regulation of membrane potential (GO:0045838)3.45897441
48cell migration in hindbrain (GO:0021535)3.36915736
49cellular potassium ion homeostasis (GO:0030007)3.36065112
50regulation of postsynaptic membrane potential (GO:0060078)3.34179888
51neuronal ion channel clustering (GO:0045161)3.29796794
52mitochondrion transport along microtubule (GO:0047497)3.29079672
53establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.29079672
54central nervous system projection neuron axonogenesis (GO:0021952)3.28694274
55regulation of dendritic spine morphogenesis (GO:0061001)3.28614913
56membrane hyperpolarization (GO:0060081)3.23564639
57auditory behavior (GO:0031223)3.23042372
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.21306136
59postsynaptic membrane organization (GO:0001941)3.20639329
60neurotransmitter transport (GO:0006836)3.18797424
61positive regulation of synapse maturation (GO:0090129)3.17864685
62adult walking behavior (GO:0007628)3.16218054
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.14059099
64regulation of neurotransmitter secretion (GO:0046928)3.12525348
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.11889689
66response to auditory stimulus (GO:0010996)3.11041271
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.08259603
68L-amino acid import (GO:0043092)3.07131126
69membrane depolarization during action potential (GO:0086010)3.06615449
70regulation of synaptic plasticity (GO:0048167)3.05354901
71long-term synaptic potentiation (GO:0060291)3.03127377
72neuromuscular process controlling balance (GO:0050885)3.02866646
73regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01914650
74startle response (GO:0001964)3.01361579
75prepulse inhibition (GO:0060134)3.00733850
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.98179438
77synapse assembly (GO:0007416)2.97851169
78membrane depolarization (GO:0051899)2.97411379
79proline transport (GO:0015824)2.93912085
80positive regulation of dendritic spine development (GO:0060999)2.93517610
81positive regulation of synaptic transmission, GABAergic (GO:0032230)2.92817045
82negative regulation of cytosolic calcium ion concentration (GO:0051481)2.92240021
83dendritic spine organization (GO:0097061)2.91021546
84regulation of vesicle fusion (GO:0031338)2.90965161
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.90575132
86learning (GO:0007612)2.89457698
87regulation of dendritic spine development (GO:0060998)2.88590212
88regulation of neurotransmitter levels (GO:0001505)2.87662884
89axon ensheathment in central nervous system (GO:0032291)2.87502963
90central nervous system myelination (GO:0022010)2.87502963
91negative regulation of synaptic transmission, GABAergic (GO:0032229)2.87398250
92regulation of neurotransmitter transport (GO:0051588)2.85523139
93innervation (GO:0060384)2.84875778
94pyrimidine nucleobase catabolic process (GO:0006208)2.84846941
95sodium ion export (GO:0071436)2.83420736
96mechanosensory behavior (GO:0007638)2.83253050
97nerve growth factor signaling pathway (GO:0038180)2.83050430
98establishment of nucleus localization (GO:0040023)2.82843589
99synapse organization (GO:0050808)2.82311512
100cell differentiation in hindbrain (GO:0021533)2.80533451
101glycine transport (GO:0015816)2.79799310
102retinal ganglion cell axon guidance (GO:0031290)2.78138580
103regulation of ARF protein signal transduction (GO:0032012)2.77176382
104positive regulation of synapse assembly (GO:0051965)2.76326553
105vesicle transport along microtubule (GO:0047496)2.75863166
106behavioral response to nicotine (GO:0035095)2.73892694
107regulation of synapse maturation (GO:0090128)2.73389799
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.72726323
109cerebellum development (GO:0021549)2.72109470
110positive regulation of dendritic spine morphogenesis (GO:0061003)2.70601320
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.70465305
112cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68075968
113neuromuscular synaptic transmission (GO:0007274)2.65782303
114glycosphingolipid biosynthetic process (GO:0006688)2.60480940
115cochlea development (GO:0090102)2.56881946
116multicellular organismal signaling (GO:0035637)2.56357001
117central nervous system neuron axonogenesis (GO:0021955)2.55426350
118cell communication by electrical coupling (GO:0010644)2.55091097
119cell communication involved in cardiac conduction (GO:0086065)2.53315774
120regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.52712584
121C4-dicarboxylate transport (GO:0015740)2.52536116
122calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50754898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.60967183
2GBX2_23144817_ChIP-Seq_PC3_Human3.62586428
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74054312
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.65409176
5REST_21632747_ChIP-Seq_MESCs_Mouse2.64614516
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61701773
7* DROSHA_22980978_ChIP-Seq_HELA_Human2.54253558
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37563088
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37563088
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.30349940
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.30125930
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28173739
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24722348
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24255241
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.21041633
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.19774536
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.19346613
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17094126
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16100641
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.14665785
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.14584510
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11112132
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05896738
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.05356182
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95124250
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.94868526
27* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79661006
28TAF15_26573619_Chip-Seq_HEK293_Human1.79293402
29AR_21572438_ChIP-Seq_LNCaP_Human1.79108119
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78633079
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71639771
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66623885
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64954712
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60520980
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60246009
36SMAD4_21799915_ChIP-Seq_A2780_Human1.58955895
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58887014
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58628237
39IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52315329
40BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45863818
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39853531
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.39705874
43P300_19829295_ChIP-Seq_ESCs_Human1.38659864
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38218637
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.36890422
46SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34708934
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33946647
48ZNF274_21170338_ChIP-Seq_K562_Hela1.33304676
49STAT3_23295773_ChIP-Seq_U87_Human1.32727327
50VDR_22108803_ChIP-Seq_LS180_Human1.30072359
51RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.29553470
52* SOX2_21211035_ChIP-Seq_LN229_Gbm1.29114313
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27407355
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27407355
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27153416
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.26608413
57RNF2_27304074_Chip-Seq_NSC_Mouse1.26574278
58P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25557890
59RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24208220
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22659410
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.21856672
62AR_19668381_ChIP-Seq_PC3_Human1.19514141
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.19188134
64TCF4_23295773_ChIP-Seq_U87_Human1.19052254
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18784729
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18527045
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.17852975
68AR_25329375_ChIP-Seq_VCAP_Human1.17617327
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.16639988
70RING1B_27294783_Chip-Seq_NPCs_Mouse1.16402240
71* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15461809
72BCAT_22108803_ChIP-Seq_LS180_Human1.15430995
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15409456
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15240751
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14526647
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.13575067
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13361147
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13352132
79NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12933113
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11922597
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07967205
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07935468
83AHR_22903824_ChIP-Seq_MCF-7_Human1.07477428
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06632985
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05335069
86IGF1R_20145208_ChIP-Seq_DFB_Human1.04236715
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03793305
88CBP_20019798_ChIP-Seq_JUKART_Human1.03793305
89LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03461173
90ER_23166858_ChIP-Seq_MCF-7_Human1.02543245
91* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02470521
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.02314079
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00332418
94TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00029963
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.99722165
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.99365661
97PRDM14_20953172_ChIP-Seq_ESCs_Human0.99152585
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98977619
99RUNX2_22187159_ChIP-Seq_PCA_Human0.97734677
100* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96713759
101GATA1_26923725_Chip-Seq_HPCs_Mouse0.95537252
102CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95447818
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.94349059
104TCF4_22108803_ChIP-Seq_LS180_Human0.93824732
105KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93696680
106* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93556141
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93452099
108KDM2B_26808549_Chip-Seq_K562_Human0.93073730
109FUS_26573619_Chip-Seq_HEK293_Human0.93051616
110STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93045568
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92745857
112WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92270825
113CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91759216
114TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91641555
115CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90243133

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.74267903
2MP0003880_abnormal_central_pattern4.69154194
3MP0003635_abnormal_synaptic_transmissio3.85276320
4MP0004270_analgesia3.66505572
5MP0002063_abnormal_learning/memory/cond3.11837014
6MP0005423_abnormal_somatic_nervous3.10639251
7MP0009745_abnormal_behavioral_response3.08224902
8MP0002064_seizures2.98196502
9MP0009046_muscle_twitch2.95300755
10MP0001486_abnormal_startle_reflex2.65322723
11MP0002572_abnormal_emotion/affect_behav2.65304329
12MP0000778_abnormal_nervous_system2.61502621
13MP0002272_abnormal_nervous_system2.56519443
14MP0002734_abnormal_mechanical_nocicepti2.52150559
15MP0001968_abnormal_touch/_nociception2.45906687
16MP0001984_abnormal_olfaction2.37148789
17MP0001440_abnormal_grooming_behavior2.00279978
18MP0002184_abnormal_innervation1.94405433
19MP0002067_abnormal_sensory_capabilities1.93888322
20MP0002822_catalepsy1.93785387
21MP0002735_abnormal_chemical_nociception1.92680225
22MP0002557_abnormal_social/conspecific_i1.90433216
23MP0004811_abnormal_neuron_physiology1.88331020
24MP0005645_abnormal_hypothalamus_physiol1.88180803
25MP0000569_abnormal_digit_pigmentation1.83677259
26MP0002733_abnormal_thermal_nociception1.80623665
27MP0008569_lethality_at_weaning1.80039890
28MP0005646_abnormal_pituitary_gland1.77324390
29MP0000955_abnormal_spinal_cord1.77190511
30MP0004885_abnormal_endolymph1.76631984
31MP0001970_abnormal_pain_threshold1.74917135
32MP0009780_abnormal_chondrocyte_physiolo1.74282435
33MP0001501_abnormal_sleep_pattern1.74126821
34MP0004924_abnormal_behavior1.70086020
35MP0005386_behavior/neurological_phenoty1.70086020
36MP0002882_abnormal_neuron_morphology1.67921062
37MP0002736_abnormal_nociception_after1.64169443
38MP0006276_abnormal_autonomic_nervous1.64110364
39MP0001529_abnormal_vocalization1.61004981
40MP0001502_abnormal_circadian_rhythm1.58906455
41MP0003121_genomic_imprinting1.58115584
42MP0003329_amyloid_beta_deposits1.57980047
43MP0005551_abnormal_eye_electrophysiolog1.56458133
44MP0000566_synostosis1.52250790
45MP0002066_abnormal_motor_capabilities/c1.46893870
46MP0004742_abnormal_vestibular_system1.43663457
47MP0000920_abnormal_myelination1.43387012
48MP0002152_abnormal_brain_morphology1.35882303
49MP0004858_abnormal_nervous_system1.34211605
50MP0003879_abnormal_hair_cell1.31835680
51MP0004142_abnormal_muscle_tone1.31550884
52MP0008877_abnormal_DNA_methylation1.29919930
53MP0003787_abnormal_imprinting1.29566136
54MP0002909_abnormal_adrenal_gland1.27070384
55MP0005499_abnormal_olfactory_system1.26502199
56MP0005394_taste/olfaction_phenotype1.26502199
57MP0003633_abnormal_nervous_system1.25752787
58MP0002229_neurodegeneration1.25297826
59MP0005409_darkened_coat_color1.23495680
60MP0001905_abnormal_dopamine_level1.23374344
61MP0003690_abnormal_glial_cell1.22879262
62MP0002102_abnormal_ear_morphology1.19650157
63MP0003122_maternal_imprinting1.17959728
64MP0003631_nervous_system_phenotype1.15404005
65MP0003634_abnormal_glial_cell1.15165365
66MP0003123_paternal_imprinting1.14994920
67MP0002752_abnormal_somatic_nervous1.10378654
68MP0000631_abnormal_neuroendocrine_gland1.09218177
69MP0005410_abnormal_fertilization1.06788030
70MP0006072_abnormal_retinal_apoptosis1.03861655
71MP0003632_abnormal_nervous_system1.01843396
72MP0002069_abnormal_eating/drinking_beha1.01358986
73MP0001188_hyperpigmentation0.96670405
74MP0001963_abnormal_hearing_physiology0.95023267
75MP0001485_abnormal_pinna_reflex0.94862460
76MP0004145_abnormal_muscle_electrophysio0.94320792
77MP0001986_abnormal_taste_sensitivity0.94197910
78MP0004133_heterotaxia0.93770080
79MP0005253_abnormal_eye_physiology0.93297233
80MP0002638_abnormal_pupillary_reflex0.93002343
81MP0008961_abnormal_basal_metabolism0.92935348
82MP0002876_abnormal_thyroid_physiology0.92421521
83MP0003861_abnormal_nervous_system0.91921474
84MP0003938_abnormal_ear_development0.91862758
85MP0002653_abnormal_ependyma_morphology0.87563443
86MP0001177_atelectasis0.87228175
87MP0003119_abnormal_digestive_system0.83002351
88MP0004147_increased_porphyrin_level0.80437398
89MP0003183_abnormal_peptide_metabolism0.79884372
90MP0003890_abnormal_embryonic-extraembry0.79017912
91MP0008789_abnormal_olfactory_epithelium0.77677063
92MP0002751_abnormal_autonomic_nervous0.77621495
93MP0006292_abnormal_olfactory_placode0.72685848
94MP0004085_abnormal_heartbeat0.72501789
95MP0002090_abnormal_vision0.70807396
96MP0005195_abnormal_posterior_eye0.70709285
97MP0003698_abnormal_male_reproductive0.70491126
98MP0000604_amyloidosis0.70457270
99MP0005377_hearing/vestibular/ear_phenot0.70406558
100MP0003878_abnormal_ear_physiology0.70406558
101MP0005187_abnormal_penis_morphology0.69916472
102MP0003137_abnormal_impulse_conducting0.68900931
103MP0000026_abnormal_inner_ear0.68013467
104MP0001299_abnormal_eye_distance/0.67322084
105MP0005248_abnormal_Harderian_gland0.66366569
106MP0008872_abnormal_physiological_respon0.66168838
107MP0010386_abnormal_urinary_bladder0.66046990
108MP0003283_abnormal_digestive_organ0.65821952
109MP0002837_dystrophic_cardiac_calcinosis0.65110181
110MP0002082_postnatal_lethality0.63363827
111MP0010770_preweaning_lethality0.63363827
112MP0010769_abnormal_survival0.62970022
113MP0004215_abnormal_myocardial_fiber0.61537543
114MP0001943_abnormal_respiration0.61479432
115MP0010768_mortality/aging0.59197744
116MP0004233_abnormal_muscle_weight0.58933118
117MP0005535_abnormal_body_temperature0.58412551
118MP0004043_abnormal_pH_regulation0.57090261
119MP0001664_abnormal_digestion0.56488041

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.76924852
2Myokymia (HP:0002411)5.42854669
3Focal seizures (HP:0007359)5.01343927
4Epileptic encephalopathy (HP:0200134)4.39264440
5Progressive cerebellar ataxia (HP:0002073)4.09634887
6Supranuclear gaze palsy (HP:0000605)3.94099237
7Visual hallucinations (HP:0002367)3.91596339
8Febrile seizures (HP:0002373)3.66690582
9Atonic seizures (HP:0010819)3.65828388
10Ankle clonus (HP:0011448)3.56473775
11Mutism (HP:0002300)3.54618817
12Broad-based gait (HP:0002136)3.54323019
13Absence seizures (HP:0002121)3.37607481
14Action tremor (HP:0002345)3.36515593
15Dialeptic seizures (HP:0011146)3.29219151
16Abnormality of the corticospinal tract (HP:0002492)3.17287631
17Generalized tonic-clonic seizures (HP:0002069)3.06724929
18Neurofibrillary tangles (HP:0002185)3.06692931
19Spastic gait (HP:0002064)3.00991943
20Excessive salivation (HP:0003781)3.00793228
21Drooling (HP:0002307)3.00793228
22Hyperventilation (HP:0002883)2.99232633
23Urinary bladder sphincter dysfunction (HP:0002839)2.96324702
24Absent/shortened dynein arms (HP:0200106)2.91951073
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.91951073
26Polyphagia (HP:0002591)2.88131392
27Dysmetria (HP:0001310)2.86681567
28Gaze-evoked nystagmus (HP:0000640)2.85259907
29Abnormal eating behavior (HP:0100738)2.84214012
30Truncal ataxia (HP:0002078)2.83245614
31Genetic anticipation (HP:0003743)2.80740284
32Hemiparesis (HP:0001269)2.77442275
33Limb dystonia (HP:0002451)2.75663932
34Poor eye contact (HP:0000817)2.74607637
35Impaired vibration sensation in the lower limbs (HP:0002166)2.72728753
36Dysdiadochokinesis (HP:0002075)2.71036941
37Postural instability (HP:0002172)2.64407566
38Amyotrophic lateral sclerosis (HP:0007354)2.63029456
39Cerebral inclusion bodies (HP:0100314)2.56257552
40Depression (HP:0000716)2.56237050
41Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.55470064
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.55470064
43Urinary urgency (HP:0000012)2.52200423
44Absent speech (HP:0001344)2.51536370
45Abnormal social behavior (HP:0012433)2.50735134
46Impaired social interactions (HP:0000735)2.50735134
47Insidious onset (HP:0003587)2.46007790
48Termporal pattern (HP:0011008)2.46007790
49Intention tremor (HP:0002080)2.42734988
50Stereotypic behavior (HP:0000733)2.40545598
51Scanning speech (HP:0002168)2.37666358
52Epileptiform EEG discharges (HP:0011182)2.36942831
53Sleep apnea (HP:0010535)2.36488364
54Amblyopia (HP:0000646)2.35957001
55EEG with generalized epileptiform discharges (HP:0011198)2.34529743
56Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.31261050
57Nephronophthisis (HP:0000090)2.30946407
58Inappropriate behavior (HP:0000719)2.29331089
59Spastic tetraplegia (HP:0002510)2.29263983
60Akinesia (HP:0002304)2.28881620
61Abnormality of the lower motor neuron (HP:0002366)2.27211421
62Anxiety (HP:0000739)2.27131437
63Lower limb muscle weakness (HP:0007340)2.25713976
64Medial flaring of the eyebrow (HP:0010747)2.23877815
65Megalencephaly (HP:0001355)2.23332566
66Gait imbalance (HP:0002141)2.22975514
67Hypsarrhythmia (HP:0002521)2.21991080
68Pachygyria (HP:0001302)2.21796310
69Torticollis (HP:0000473)2.20195869
70Hepatoblastoma (HP:0002884)2.19776718
71Genital tract atresia (HP:0001827)2.18858093
72Agitation (HP:0000713)2.17439288
73Congenital primary aphakia (HP:0007707)2.17037691
74Specific learning disability (HP:0001328)2.15935893
75Progressive inability to walk (HP:0002505)2.14882324
76Central scotoma (HP:0000603)2.13812586
77Vaginal atresia (HP:0000148)2.12943883
78Papilledema (HP:0001085)2.11649579
79Nephrogenic diabetes insipidus (HP:0009806)2.11223201
80Protruding tongue (HP:0010808)2.10626981
81Abnormal respiratory motile cilium physiology (HP:0012261)2.08066818
82Abnormality of binocular vision (HP:0011514)2.07525758
83Diplopia (HP:0000651)2.07525758
84Impaired smooth pursuit (HP:0007772)2.04157029
85Widely spaced teeth (HP:0000687)2.03957437
86Hemiplegia (HP:0002301)2.03347887
87Abnormality of salivation (HP:0100755)2.02736266
88Clonus (HP:0002169)2.01126737
89Syncope (HP:0001279)2.00733227
90Generalized myoclonic seizures (HP:0002123)2.00387096
91Blue irides (HP:0000635)2.00351767
92Abnormal ciliary motility (HP:0012262)2.00280907
93Focal dystonia (HP:0004373)1.99980603
94Insomnia (HP:0100785)1.99274137
95Pancreatic fibrosis (HP:0100732)1.97604136
96Decreased circulating renin level (HP:0003351)1.97210109
97Neuronal loss in central nervous system (HP:0002529)1.97090230
98Fetal akinesia sequence (HP:0001989)1.96823578
99Status epilepticus (HP:0002133)1.96008530
100Hypoplasia of the brainstem (HP:0002365)1.95901575
101Aplasia/Hypoplasia of the brainstem (HP:0007362)1.95901575
102Pheochromocytoma (HP:0002666)1.95376204
103Hypoplasia of the corpus callosum (HP:0002079)1.94629875
104Lissencephaly (HP:0001339)1.93913794
105Abnormality of ocular smooth pursuit (HP:0000617)1.93860271
106True hermaphroditism (HP:0010459)1.92498275
107Bradykinesia (HP:0002067)1.90062255
108Abnormality of the renal medulla (HP:0100957)1.89825420
109Morphological abnormality of the pyramidal tract (HP:0002062)1.88774045
110Retinal dysplasia (HP:0007973)1.87517945
111Inability to walk (HP:0002540)1.85114401
112Exotropia (HP:0000577)1.84087015
113Abnormality of macular pigmentation (HP:0008002)1.83749304
114Abnormal respiratory epithelium morphology (HP:0012253)1.83428996
115Abnormal respiratory motile cilium morphology (HP:0005938)1.83428996
116Chronic hepatic failure (HP:0100626)1.82938683
117Failure to thrive in infancy (HP:0001531)1.82472405
118Pointed chin (HP:0000307)1.80675699
119Pancreatic cysts (HP:0001737)1.80453670
120Impaired vibratory sensation (HP:0002495)1.80420173
121Abnormality of renin-angiotensin system (HP:0000847)1.79974998
122Poor coordination (HP:0002370)1.79745778
123Abnormality of midbrain morphology (HP:0002418)1.79726716
124Molar tooth sign on MRI (HP:0002419)1.79726716
125Type II lissencephaly (HP:0007260)1.76436490
126Aqueductal stenosis (HP:0002410)1.76235751
127Prolonged QT interval (HP:0001657)1.74859767
128Cystic liver disease (HP:0006706)1.72827101
129Optic nerve hypoplasia (HP:0000609)1.70869058
130Muscular hypotonia of the trunk (HP:0008936)1.69478505

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.48931942
2NTRK33.58121916
3EPHA43.55231965
4MAP3K93.20034906
5MAP3K42.61033654
6FRK2.48884381
7PAK62.41062446
8MINK12.33746054
9NTRK22.25573657
10TNIK2.06011334
11MAP2K72.05617573
12UHMK12.00237672
13DAPK21.93538799
14PRKD31.85735295
15MAPK131.85259561
16KSR11.67132983
17CASK1.55145938
18CDK51.52781096
19SIK21.50488145
20PNCK1.50412094
21TYRO31.50160301
22MAP4K21.48859780
23CAMKK11.48422779
24ICK1.47502130
25PRPF4B1.44728790
26SGK4941.43010352
27SGK2231.43010352
28PHKG11.38613519
29PHKG21.38613519
30NTRK11.32080060
31OXSR11.29244015
32CDK191.25071976
33EPHA31.24830014
34MAP2K41.24641450
35KSR21.15712369
36STK391.14879401
37BCR1.14050893
38PLK21.11564142
39RIPK41.10405977
40CSNK1G21.09503552
41BMPR21.08661642
42MARK21.06985823
43CAMK1G1.05304957
44PAK31.04739951
45PKN11.03976301
46WNK31.01984371
47STK381.01194300
48PRKCG0.99701206
49FES0.97643292
50CDK180.97009711
51SGK20.94968371
52CDK150.94232877
53DYRK1A0.93463336
54NEK60.92962876
55CDK140.91778697
56DYRK20.91652617
57CAMKK20.91540306
58STK110.90277873
59DAPK10.90240094
60CAMK2A0.88822414
61TRIM280.87207985
62CDC42BPA0.86804068
63GRK10.86480813
64SGK30.85970839
65STK38L0.85050016
66CAMK2B0.84463763
67CDK11A0.81257196
68CCNB10.80383383
69WNK10.79247426
70CSNK1A1L0.78809855
71SGK10.76677787
72CAMK10.75641283
73CSNK1G30.74980371
74BRSK10.74107232
75PRKCH0.71367765
76PRKAA10.68909646
77FGFR20.68457783
78IRAK20.65940838
79ACVR1B0.64845697
80GRK50.64663542
81MAPK150.64160428
82DYRK1B0.62779850
83PRKCZ0.61242535
84INSRR0.60165949
85PINK10.56892799
86FGR0.56059287
87FYN0.55707275
88ERBB30.55450118
89SIK30.54478228
90CSNK1A10.54437525
91WNK40.54410228
92MAP3K20.54358332
93RPS6KA30.53805330
94CAMK2D0.53100265
95AKT30.52639348
96MAP3K120.52630358
97DMPK0.52191076
98RET0.50565206
99TAOK10.50130495
100MAPK100.49856167
101CSNK1G10.46478710
102PRKACA0.45915814
103MAP3K130.44389450
104PRKG10.43512008
105CSNK1D0.43260284
106PRKCE0.43200202
107ROCK20.43010870
108ADRBK20.42464717
109LMTK20.41656911
110PDK10.41050479
111CAMK40.41010380
112PTK2B0.40373412
113LATS20.40263752
114PDPK10.40006298
115CSNK1E0.37916580
116ERBB20.37321453
117ALK0.37180056
118DYRK30.36162119
119OBSCN0.36138066
120RPS6KA20.35453924
121EPHB20.34860904
122CAMK2G0.34659222
123CAMK1D0.34166112
124MAP3K60.34130465
125FER0.32861770

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62807216
2Synaptic vesicle cycle_Homo sapiens_hsa047212.97626612
3Olfactory transduction_Homo sapiens_hsa047402.68429642
4Glutamatergic synapse_Homo sapiens_hsa047242.67895915
5GABAergic synapse_Homo sapiens_hsa047272.67824664
6Circadian entrainment_Homo sapiens_hsa047132.61443656
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.59739182
8Morphine addiction_Homo sapiens_hsa050322.49477337
9Long-term potentiation_Homo sapiens_hsa047202.31613755
10Amphetamine addiction_Homo sapiens_hsa050312.23587873
11Dopaminergic synapse_Homo sapiens_hsa047282.12256392
12Salivary secretion_Homo sapiens_hsa049701.96204307
13Insulin secretion_Homo sapiens_hsa049111.95574208
14Cholinergic synapse_Homo sapiens_hsa047251.89795625
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85417594
16Axon guidance_Homo sapiens_hsa043601.74244470
17Gastric acid secretion_Homo sapiens_hsa049711.70955761
18Taste transduction_Homo sapiens_hsa047421.70925405
19Cocaine addiction_Homo sapiens_hsa050301.67090123
20Serotonergic synapse_Homo sapiens_hsa047261.65520810
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.64358774
22Renin secretion_Homo sapiens_hsa049241.63563416
23Long-term depression_Homo sapiens_hsa047301.63445517
24Phototransduction_Homo sapiens_hsa047441.57473392
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.54065598
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.52945963
27Oxytocin signaling pathway_Homo sapiens_hsa049211.51781502
28Calcium signaling pathway_Homo sapiens_hsa040201.40234947
29Gap junction_Homo sapiens_hsa045401.32588110
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32031421
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31738596
32Type II diabetes mellitus_Homo sapiens_hsa049301.30009710
33GnRH signaling pathway_Homo sapiens_hsa049121.29589758
34Collecting duct acid secretion_Homo sapiens_hsa049661.26877106
35Butanoate metabolism_Homo sapiens_hsa006501.26254862
36cAMP signaling pathway_Homo sapiens_hsa040241.25349495
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24564536
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22532684
39ErbB signaling pathway_Homo sapiens_hsa040121.13858290
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07524038
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06426189
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05080902
43Estrogen signaling pathway_Homo sapiens_hsa049151.05072085
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02412791
45Dorso-ventral axis formation_Homo sapiens_hsa043201.01405740
46Linoleic acid metabolism_Homo sapiens_hsa005911.01072168
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00784717
48Histidine metabolism_Homo sapiens_hsa003400.93843618
49Melanogenesis_Homo sapiens_hsa049160.92107409
50Glioma_Homo sapiens_hsa052140.91765112
51Pancreatic secretion_Homo sapiens_hsa049720.90987532
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.89687055
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.86043638
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.85995032
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85428621
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84785457
57Choline metabolism in cancer_Homo sapiens_hsa052310.82551414
58Fat digestion and absorption_Homo sapiens_hsa049750.82256340
59Vibrio cholerae infection_Homo sapiens_hsa051100.81427566
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81104144
61MAPK signaling pathway_Homo sapiens_hsa040100.79750760
62Oocyte meiosis_Homo sapiens_hsa041140.79147831
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79038290
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78934133
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.77727114
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77241483
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75752400
68Mineral absorption_Homo sapiens_hsa049780.72686535
69Regulation of autophagy_Homo sapiens_hsa041400.69752581
70Thyroid hormone synthesis_Homo sapiens_hsa049180.67839466
71beta-Alanine metabolism_Homo sapiens_hsa004100.67309875
72Cardiac muscle contraction_Homo sapiens_hsa042600.67267842
73ABC transporters_Homo sapiens_hsa020100.67118653
74Renal cell carcinoma_Homo sapiens_hsa052110.66938325
75Circadian rhythm_Homo sapiens_hsa047100.66738478
76Tight junction_Homo sapiens_hsa045300.64697580
77VEGF signaling pathway_Homo sapiens_hsa043700.64572745
78Ras signaling pathway_Homo sapiens_hsa040140.64396777
79Inositol phosphate metabolism_Homo sapiens_hsa005620.64005219
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.63684888
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61525613
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.61358931
83Dilated cardiomyopathy_Homo sapiens_hsa054140.61142623
84Alcoholism_Homo sapiens_hsa050340.61101383
85Endometrial cancer_Homo sapiens_hsa052130.61092025
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60889910
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.60497135
88Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59864331
89Wnt signaling pathway_Homo sapiens_hsa043100.59536911
90Endocytosis_Homo sapiens_hsa041440.58950099
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58531157
92AMPK signaling pathway_Homo sapiens_hsa041520.56003978
93Protein digestion and absorption_Homo sapiens_hsa049740.55636541
94Arginine and proline metabolism_Homo sapiens_hsa003300.55146410
95Nitrogen metabolism_Homo sapiens_hsa009100.53364582
96Arginine biosynthesis_Homo sapiens_hsa002200.53046427
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52893306
98Rap1 signaling pathway_Homo sapiens_hsa040150.52797063
99Vitamin digestion and absorption_Homo sapiens_hsa049770.52366386
100mTOR signaling pathway_Homo sapiens_hsa041500.51528779
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50220090
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49693702
103Ovarian steroidogenesis_Homo sapiens_hsa049130.49572372
104Glucagon signaling pathway_Homo sapiens_hsa049220.48752427
105Colorectal cancer_Homo sapiens_hsa052100.48055887
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47934370
107Tryptophan metabolism_Homo sapiens_hsa003800.47696121
108Hippo signaling pathway_Homo sapiens_hsa043900.46958058
109Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46428864
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46246861
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45140221
112Ether lipid metabolism_Homo sapiens_hsa005650.45052929
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44642085
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44392148
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43808010
116Propanoate metabolism_Homo sapiens_hsa006400.43773122
117Steroid biosynthesis_Homo sapiens_hsa001000.43051624
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42805820
119Chemical carcinogenesis_Homo sapiens_hsa052040.41889239
120Chemokine signaling pathway_Homo sapiens_hsa040620.41820418
121Fatty acid metabolism_Homo sapiens_hsa012120.41555964
122Caffeine metabolism_Homo sapiens_hsa002320.41174149
123Glycerolipid metabolism_Homo sapiens_hsa005610.40994535
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.40831851
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37970472
126Non-small cell lung cancer_Homo sapiens_hsa052230.37361669
127Hedgehog signaling pathway_Homo sapiens_hsa043400.35953264
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33073704
129Insulin signaling pathway_Homo sapiens_hsa049100.32241742
130Bile secretion_Homo sapiens_hsa049760.31242597
131Fatty acid biosynthesis_Homo sapiens_hsa000610.31068595
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30672526

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »