RALGAPA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21637459
2locomotory exploration behavior (GO:0035641)4.81379093
3synaptic vesicle maturation (GO:0016188)4.56673446
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41842945
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35911778
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.08949367
7glutamate secretion (GO:0014047)4.07300348
8regulation of synaptic vesicle exocytosis (GO:2000300)3.99010991
9synaptic vesicle docking involved in exocytosis (GO:0016081)3.97990315
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.97444528
11vocalization behavior (GO:0071625)3.96960582
12regulation of glutamate receptor signaling pathway (GO:1900449)3.92339736
13synaptic vesicle exocytosis (GO:0016079)3.90994841
14protein localization to synapse (GO:0035418)3.73032265
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.66453678
16cerebellar Purkinje cell differentiation (GO:0021702)3.66310487
17exploration behavior (GO:0035640)3.64075016
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.63494093
19glutamate receptor signaling pathway (GO:0007215)3.61742195
20embryonic retina morphogenesis in camera-type eye (GO:0060059)3.53997215
21layer formation in cerebral cortex (GO:0021819)3.51715760
22regulation of synaptic vesicle transport (GO:1902803)3.51455042
23synaptic transmission, glutamatergic (GO:0035249)3.50628784
24proline transport (GO:0015824)3.48693016
25neuron cell-cell adhesion (GO:0007158)3.46503256
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41439518
27cellular potassium ion homeostasis (GO:0030007)3.40256663
28activation of protein kinase A activity (GO:0034199)3.37216185
29regulation of neuronal synaptic plasticity (GO:0048168)3.35456377
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.35253604
31dendritic spine morphogenesis (GO:0060997)3.33273886
32neurotransmitter secretion (GO:0007269)3.28032018
33neuron-neuron synaptic transmission (GO:0007270)3.27106874
34neuronal action potential propagation (GO:0019227)3.22904084
35dendrite morphogenesis (GO:0048813)3.21221968
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.18309917
37nucleus localization (GO:0051647)3.17902452
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.16166465
39regulation of synapse structural plasticity (GO:0051823)3.16143898
40membrane depolarization during action potential (GO:0086010)3.14719761
41cytoplasmic mRNA processing body assembly (GO:0033962)3.14662669
42sodium ion export (GO:0071436)3.09594709
43cell communication by electrical coupling (GO:0010644)3.09314965
44establishment of nucleus localization (GO:0040023)3.06541219
45regulation of postsynaptic membrane potential (GO:0060078)3.05764115
46positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05626452
47long-term memory (GO:0007616)3.05546769
48interkinetic nuclear migration (GO:0022027)3.05302776
49macroautophagy (GO:0016236)3.03866106
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02271184
51neuron recognition (GO:0008038)2.99827848
52nerve growth factor signaling pathway (GO:0038180)2.99791816
53regulation of ARF protein signal transduction (GO:0032012)2.95910225
54gamma-aminobutyric acid transport (GO:0015812)2.95597942
55innervation (GO:0060384)2.93214821
56positive regulation of dendritic spine morphogenesis (GO:0061003)2.91909770
57vesicle transport along microtubule (GO:0047496)2.91428648
58neurotransmitter-gated ion channel clustering (GO:0072578)2.91351123
59axonal fasciculation (GO:0007413)2.90124453
60regulation of dendritic spine morphogenesis (GO:0061001)2.88643150
61gamma-aminobutyric acid signaling pathway (GO:0007214)2.87930994
62synaptic vesicle endocytosis (GO:0048488)2.85934638
63negative regulation of neurotransmitter secretion (GO:0046929)2.85912058
64long-term synaptic potentiation (GO:0060291)2.85675376
65G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85231829
66transmission of nerve impulse (GO:0019226)2.84411476
67regulation of synaptic plasticity (GO:0048167)2.84203946
68presynaptic membrane assembly (GO:0097105)2.81833802
69regulation of neurotransmitter secretion (GO:0046928)2.78408659
70membrane depolarization (GO:0051899)2.77756252
71regulation of synaptic transmission, glutamatergic (GO:0051966)2.77338558
72regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.76779560
73positive regulation of membrane potential (GO:0045838)2.75622722
74Golgi to endosome transport (GO:0006895)2.75445071
75regulation of vesicle fusion (GO:0031338)2.75416370
76regulation of establishment of cell polarity (GO:2000114)2.72604547
77regulation of energy homeostasis (GO:2000505)2.71082764
78potassium ion import (GO:0010107)2.70267177
79establishment of protein localization to Golgi (GO:0072600)2.69976726
80regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.68690906
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.68041391
82response to pheromone (GO:0019236)2.67969393
83suckling behavior (GO:0001967)2.67678799
84pyrimidine nucleobase catabolic process (GO:0006208)2.66607572
85phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.66596859
86cellular sodium ion homeostasis (GO:0006883)2.66212602
87regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65053331
88positive regulation of synaptic transmission, GABAergic (GO:0032230)2.64636550
89neuromuscular process controlling balance (GO:0050885)2.64611183
90cellular response to ethanol (GO:0071361)2.64031092
91negative regulation of neurotransmitter transport (GO:0051589)2.63541984
92presynaptic membrane organization (GO:0097090)2.62368682
93protein targeting to Golgi (GO:0000042)2.62252034
94positive regulation of synapse maturation (GO:0090129)2.61920714
95central nervous system neuron axonogenesis (GO:0021955)2.61919061
96detection of calcium ion (GO:0005513)2.61849836
97regulation of non-canonical Wnt signaling pathway (GO:2000050)2.60756978
98eye photoreceptor cell differentiation (GO:0001754)2.59757880
99photoreceptor cell differentiation (GO:0046530)2.59757880
100neurotransmitter transport (GO:0006836)2.58974922
101phospholipid translocation (GO:0045332)2.58474771
102lipid translocation (GO:0034204)2.58474771
103C4-dicarboxylate transport (GO:0015740)2.57136271
104chemosensory behavior (GO:0007635)2.56476295
105negative regulation of synaptic transmission, GABAergic (GO:0032229)2.55930976
106clathrin coat assembly (GO:0048268)2.55177020
107membrane hyperpolarization (GO:0060081)2.55107173
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.55032993
109dendritic spine organization (GO:0097061)2.54108561
110response to histamine (GO:0034776)2.53795929
111prepulse inhibition (GO:0060134)2.52963658
112retrograde transport, vesicle recycling within Golgi (GO:0000301)2.51876301
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51743947
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.49823835
115organelle transport along microtubule (GO:0072384)2.49278838
116positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.49151795
117auditory behavior (GO:0031223)2.49040001
118regulation of dendritic spine development (GO:0060998)2.49026403
119regulation of neurotransmitter transport (GO:0051588)2.48781361
120cell communication involved in cardiac conduction (GO:0086065)2.47696116
121positive regulation of muscle hypertrophy (GO:0014742)2.46765606
122positive regulation of cardiac muscle hypertrophy (GO:0010613)2.46765606
123regulation of clathrin-mediated endocytosis (GO:2000369)2.45648560
124central nervous system projection neuron axonogenesis (GO:0021952)2.45095567
125synapse assembly (GO:0007416)2.43416804
126learning (GO:0007612)2.41921138
127cell differentiation in hindbrain (GO:0021533)2.41640107
128glycine transport (GO:0015816)2.40787297
129monoubiquitinated protein deubiquitination (GO:0035520)2.39371850
130regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.38705970
131central nervous system myelination (GO:0022010)2.38070419
132axon ensheathment in central nervous system (GO:0032291)2.38070419
133protein localization to Golgi apparatus (GO:0034067)2.37771120
134negative regulation of sodium ion transport (GO:0010766)2.36908391
135regulation of sarcomere organization (GO:0060297)2.35664355
136mechanosensory behavior (GO:0007638)2.35096563
137negative regulation of dendrite development (GO:2000171)2.34969790
138regulation of establishment or maintenance of cell polarity (GO:0032878)2.30832300
139nucleobase catabolic process (GO:0046113)2.30096083
140postsynaptic membrane organization (GO:0001941)2.29272389
141positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.28703400
142positive regulation of glycolytic process (GO:0045821)2.27786194
143regulation of Rac protein signal transduction (GO:0035020)2.24670728
144limb development (GO:0060173)2.24627963
145appendage development (GO:0048736)2.24627963
146protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.24280442
147renal tubule morphogenesis (GO:0061333)2.23185057
148cyclic nucleotide catabolic process (GO:0009214)2.22965883
149positive regulation of dendritic spine development (GO:0060999)2.21078354
150regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.20833887
151histone H3-K4 trimethylation (GO:0080182)2.20450781
152histone H3-K9 demethylation (GO:0033169)2.19777645
153startle response (GO:0001964)2.18922844
154protein K11-linked deubiquitination (GO:0035871)2.18478386
155nephron tubule morphogenesis (GO:0072078)2.17075132
156nephron epithelium morphogenesis (GO:0072088)2.17075132
157cAMP catabolic process (GO:0006198)2.16627415
158early endosome to late endosome transport (GO:0045022)2.16527042
159protein targeting to lysosome (GO:0006622)2.16509071
160establishment of protein localization to vacuole (GO:0072666)2.16509071
161protein targeting to vacuole (GO:0006623)2.16509071
162microtubule anchoring (GO:0034453)2.16348506
163negative regulation of astrocyte differentiation (GO:0048712)2.15311604
164histone H3-K36 demethylation (GO:0070544)2.14642667
165genitalia morphogenesis (GO:0035112)2.13052980

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19601633
2GBX2_23144817_ChIP-Seq_PC3_Human3.53076489
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.55782006
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52763358
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47006456
6DROSHA_22980978_ChIP-Seq_HELA_Human2.39465125
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.38271007
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16282278
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16282278
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13857413
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.10984084
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09615727
13SMAD_19615063_ChIP-ChIP_OVARY_Human2.05384844
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05121538
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03616237
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02558307
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00892806
18AR_21572438_ChIP-Seq_LNCaP_Human1.97885138
19REST_21632747_ChIP-Seq_MESCs_Mouse1.97446406
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97429128
21RARB_27405468_Chip-Seq_BRAIN_Mouse1.94714443
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94475818
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.94070011
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.92391766
25SMAD4_21799915_ChIP-Seq_A2780_Human1.88299460
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.87384137
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.83402495
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.81272061
29MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.77382299
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75553936
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74419098
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68188938
33TAF15_26573619_Chip-Seq_HEK293_Human1.67981836
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67793746
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.67481071
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63559949
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61792322
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.59950285
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57958790
40ZNF217_24962896_ChIP-Seq_MCF-7_Human1.57669701
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52961897
42P300_19829295_ChIP-Seq_ESCs_Human1.52185727
43STAT3_23295773_ChIP-Seq_U87_Human1.51973341
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51604329
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.48468390
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47508073
47ARNT_22903824_ChIP-Seq_MCF-7_Human1.46377557
48AHR_22903824_ChIP-Seq_MCF-7_Human1.45468049
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43394823
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.43374277
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42332996
52* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42000205
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41739209
54SOX2_21211035_ChIP-Seq_LN229_Gbm1.41650564
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40821354
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.40775717
57VDR_22108803_ChIP-Seq_LS180_Human1.40354092
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39590636
59NR3C1_23031785_ChIP-Seq_PC12_Mouse1.39527557
60* SMAD3_21741376_ChIP-Seq_EPCs_Human1.38929871
61FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38158671
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38073635
63AR_25329375_ChIP-Seq_VCAP_Human1.37785866
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.37322364
65TCF4_23295773_ChIP-Seq_U87_Human1.36204476
66TP53_16413492_ChIP-PET_HCT116_Human1.35441946
67EWS_26573619_Chip-Seq_HEK293_Human1.33869112
68ZNF274_21170338_ChIP-Seq_K562_Hela1.32536171
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30234346
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29589359
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.29349696
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29234592
73FOXA2_19822575_ChIP-Seq_HepG2_Human1.29004419
74AR_19668381_ChIP-Seq_PC3_Human1.28715669
75* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27763985
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27029465
77IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26659358
78CBP_20019798_ChIP-Seq_JUKART_Human1.26659358
79E2F1_18555785_Chip-Seq_ESCs_Mouse1.25812343
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25791811
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24598794
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24441630
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23424571
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22778460
85NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22497467
86NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22497467
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22123743
88* FLI1_21867929_ChIP-Seq_TH2_Mouse1.22037269
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21002816
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21002816
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21000142
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20905508
93P53_22387025_ChIP-Seq_ESCs_Mouse1.20294481
94RNF2_27304074_Chip-Seq_NSC_Mouse1.19795186
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18656226
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18620540
97CMYC_18555785_Chip-Seq_ESCs_Mouse1.18495284
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.18098500
99* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15016715
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14980613
101* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.14424352
102FUS_26573619_Chip-Seq_HEK293_Human1.13900513
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13579860
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11701456
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10699818
106KDM2B_26808549_Chip-Seq_REH_Human1.10603415
107CTNNB1_20460455_ChIP-Seq_HCT116_Human1.09902865
108SMAD3_21741376_ChIP-Seq_HESCs_Human1.09441379
109TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09113891
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08612749
111TCF4_22108803_ChIP-Seq_LS180_Human1.07464374
112EP300_21415370_ChIP-Seq_HL-1_Mouse1.07300697
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06206299
114LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06049903
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05490008
116ER_23166858_ChIP-Seq_MCF-7_Human1.04807119
117NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04342340
118RUNX2_22187159_ChIP-Seq_PCA_Human1.04008886
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.03596006
120RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03428006
121BCAT_22108803_ChIP-Seq_LS180_Human1.03251282
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.02620944
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01927146
124SMAD3_21741376_ChIP-Seq_ESCs_Human1.00945149
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00622084
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.00577909
127P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00315730
128IGF1R_20145208_ChIP-Seq_DFB_Human1.00181221
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99800687
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99162622
131NANOG_18555785_Chip-Seq_ESCs_Mouse0.98479244
132STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98242170
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.98075343
134RXR_22108803_ChIP-Seq_LS180_Human0.97887834
135TP53_18474530_ChIP-ChIP_U2OS_Human0.97353731
136TCF4_18268006_ChIP-ChIP_LS174T_Human0.97132027
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.96913295
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96297101

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.78344106
2MP0003880_abnormal_central_pattern3.71977157
3MP0003635_abnormal_synaptic_transmissio3.66253699
4MP0000569_abnormal_digit_pigmentation3.34779267
5MP0004270_analgesia3.18230006
6MP0009745_abnormal_behavioral_response2.96742401
7MP0002063_abnormal_learning/memory/cond2.93224387
8MP0009046_muscle_twitch2.80202341
9MP0003787_abnormal_imprinting2.62143462
10MP0002064_seizures2.57635629
11MP0005423_abnormal_somatic_nervous2.51781593
12MP0001968_abnormal_touch/_nociception2.44350134
13MP0002572_abnormal_emotion/affect_behav2.37778222
14MP0009780_abnormal_chondrocyte_physiolo2.36372214
15MP0008057_abnormal_DNA_replication2.32254629
16MP0002734_abnormal_mechanical_nocicepti2.22590734
17MP0001486_abnormal_startle_reflex2.20602216
18MP0002272_abnormal_nervous_system2.19944853
19MP0002735_abnormal_chemical_nociception2.11318623
20MP0001501_abnormal_sleep_pattern1.92870630
21MP0003890_abnormal_embryonic-extraembry1.85387892
22MP0008569_lethality_at_weaning1.82358735
23MP0002067_abnormal_sensory_capabilities1.80338811
24MP0000778_abnormal_nervous_system1.76344119
25MP0003868_abnormal_feces_composition1.73815451
26MP0003195_calcinosis1.71584147
27MP0001440_abnormal_grooming_behavior1.69952366
28MP0005386_behavior/neurological_phenoty1.69649188
29MP0004924_abnormal_behavior1.69649188
30MP0002733_abnormal_thermal_nociception1.65295350
31MP0002909_abnormal_adrenal_gland1.63346496
32MP0002736_abnormal_nociception_after1.61382653
33MP0001970_abnormal_pain_threshold1.59730298
34MP0002822_catalepsy1.59235469
35MP0004811_abnormal_neuron_physiology1.58269785
36MP0002557_abnormal_social/conspecific_i1.56044140
37MP0003122_maternal_imprinting1.53577275
38MP0005645_abnormal_hypothalamus_physiol1.52835389
39MP0002184_abnormal_innervation1.52532178
40MP0008961_abnormal_basal_metabolism1.48563061
41MP0005646_abnormal_pituitary_gland1.45496984
42MP0004215_abnormal_myocardial_fiber1.44125025
43MP0004858_abnormal_nervous_system1.42962244
44MP0000751_myopathy1.40363954
45MP0000383_abnormal_hair_follicle1.39357009
46MP0001188_hyperpigmentation1.38555467
47MP0001984_abnormal_olfaction1.38450180
48MP0004510_myositis1.33539856
49MP0001502_abnormal_circadian_rhythm1.32172979
50MP0004885_abnormal_endolymph1.31802973
51MP0002638_abnormal_pupillary_reflex1.31271322
52MP0003123_paternal_imprinting1.28396190
53MP0010678_abnormal_skin_adnexa1.27040172
54MP0000955_abnormal_spinal_cord1.26293878
55MP0002882_abnormal_neuron_morphology1.25121306
56MP0003633_abnormal_nervous_system1.23684236
57MP0003045_fibrosis1.22818390
58MP0004043_abnormal_pH_regulation1.20369456
59MP0000427_abnormal_hair_cycle1.18355528
60MP0003183_abnormal_peptide_metabolism1.17617428
61MP0002066_abnormal_motor_capabilities/c1.14001254
62MP0003879_abnormal_hair_cell1.13484272
63MP0005379_endocrine/exocrine_gland_phen1.13354756
64MP0003690_abnormal_glial_cell1.12962599
65MP0006276_abnormal_autonomic_nervous1.12637021
66MP0004145_abnormal_muscle_electrophysio1.11387235
67MP0003121_genomic_imprinting1.10563539
68MP0002876_abnormal_thyroid_physiology1.09390629
69MP0004484_altered_response_of1.08847379
70MP0003631_nervous_system_phenotype1.06626781
71MP0005171_absent_coat_pigmentation1.05543095
72MP0005253_abnormal_eye_physiology1.05249772
73MP0010329_abnormal_lipoprotein_level1.04301301
74MP0001666_abnormal_nutrient_absorption1.01603690
75MP0004085_abnormal_heartbeat1.00754854
76MP0005551_abnormal_eye_electrophysiolog0.99950906
77MP0001177_atelectasis0.99159860
78MP0001299_abnormal_eye_distance/0.98436717
79MP0005248_abnormal_Harderian_gland0.98375962
80MP0002152_abnormal_brain_morphology0.96761923
81MP0003329_amyloid_beta_deposits0.96133541
82MP0000566_synostosis0.93951688
83MP0003943_abnormal_hepatobiliary_system0.92467348
84MP0010352_gastrointestinal_tract_polyps0.90515255
85MP0003950_abnormal_plasma_membrane0.90454330
86MP0000639_abnormal_adrenal_gland0.88767760
87MP0004130_abnormal_muscle_cell0.87115577
88MP0002837_dystrophic_cardiac_calcinosis0.86766931
89MP0010234_abnormal_vibrissa_follicle0.85019480
90MP0002009_preneoplasia0.84328390
91MP0002229_neurodegeneration0.84325676
92MP0004134_abnormal_chest_morphology0.84085040
93MP0004036_abnormal_muscle_relaxation0.83254981
94MP0002168_other_aberrant_phenotype0.82999490
95MP0003937_abnormal_limbs/digits/tail_de0.82069810
96MP0004084_abnormal_cardiac_muscle0.82062984
97MP0005220_abnormal_exocrine_pancreas0.82057750
98MP0005623_abnormal_meninges_morphology0.81471339
99MP0000013_abnormal_adipose_tissue0.81453768
100MP0003632_abnormal_nervous_system0.80946910
101MP0002160_abnormal_reproductive_system0.80530101
102MP0003646_muscle_fatigue0.79911869
103MP0004742_abnormal_vestibular_system0.79808907
104MP0008877_abnormal_DNA_methylation0.76141397
105MP0000015_abnormal_ear_pigmentation0.74581272
106MP0004233_abnormal_muscle_weight0.74217914
107MP0003252_abnormal_bile_duct0.73647237
108MP0009703_decreased_birth_body0.73484559
109MP0004142_abnormal_muscle_tone0.72695306
110MP0000462_abnormal_digestive_system0.72022009
111MP0008874_decreased_physiological_sensi0.71282547
112MP0002078_abnormal_glucose_homeostasis0.70755293
113MP0005620_abnormal_muscle_contractility0.69981999
114MP0005409_darkened_coat_color0.68740813
115MP0010386_abnormal_urinary_bladder0.67671332
116MP0005187_abnormal_penis_morphology0.67472330
117MP0003634_abnormal_glial_cell0.66060944
118MP0002069_abnormal_eating/drinking_beha0.65654690
119MP0001963_abnormal_hearing_physiology0.65214638
120MP0000631_abnormal_neuroendocrine_gland0.64582020
121MP0006072_abnormal_retinal_apoptosis0.64375320
122MP0001943_abnormal_respiration0.62723511
123MP0003172_abnormal_lysosome_physiology0.61070327
124MP0002752_abnormal_somatic_nervous0.59503529
125MP0002972_abnormal_cardiac_muscle0.59481584
126MP0003137_abnormal_impulse_conducting0.57976015
127MP0000920_abnormal_myelination0.55419057
128MP0000003_abnormal_adipose_tissue0.55310879
129MP0005499_abnormal_olfactory_system0.54912784
130MP0005394_taste/olfaction_phenotype0.54912784
131MP0005535_abnormal_body_temperature0.54901601
132MP0001905_abnormal_dopamine_level0.51819386
133MP0002108_abnormal_muscle_morphology0.51746997

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.61945705
2Focal seizures (HP:0007359)4.46549560
3Epileptic encephalopathy (HP:0200134)4.30049113
4Febrile seizures (HP:0002373)4.17750452
5Myokymia (HP:0002411)3.79019370
6Progressive cerebellar ataxia (HP:0002073)3.75344357
7Atonic seizures (HP:0010819)3.64841924
8Visual hallucinations (HP:0002367)3.50715754
9Action tremor (HP:0002345)3.46466514
10Hepatoblastoma (HP:0002884)3.44469660
11Absence seizures (HP:0002121)2.98101559
12Broad-based gait (HP:0002136)2.94192125
13Gaze-evoked nystagmus (HP:0000640)2.92197564
14Genetic anticipation (HP:0003743)2.88155739
15Truncal ataxia (HP:0002078)2.82129139
16Macroorchidism (HP:0000053)2.81557260
17Generalized tonic-clonic seizures (HP:0002069)2.75335828
18Thyroid carcinoma (HP:0002890)2.71803104
19Urinary bladder sphincter dysfunction (HP:0002839)2.70749051
20Submucous cleft hard palate (HP:0000176)2.69707559
21Drooling (HP:0002307)2.69675343
22Excessive salivation (HP:0003781)2.69675343
23Dialeptic seizures (HP:0011146)2.69508589
24Impaired smooth pursuit (HP:0007772)2.65636488
25Papilledema (HP:0001085)2.60705005
26Volvulus (HP:0002580)2.60230594
27Fair hair (HP:0002286)2.58831276
28Poor eye contact (HP:0000817)2.56786377
29Dysmetric saccades (HP:0000641)2.51375429
30Impaired vibration sensation in the lower limbs (HP:0002166)2.49496218
31Dysdiadochokinesis (HP:0002075)2.45760699
32Supranuclear gaze palsy (HP:0000605)2.42466665
33Impaired social interactions (HP:0000735)2.37257462
34Abnormal social behavior (HP:0012433)2.37257462
35Lower limb amyotrophy (HP:0007210)2.34834210
36Epidermoid cyst (HP:0200040)2.34272134
37Insidious onset (HP:0003587)2.33924391
38Termporal pattern (HP:0011008)2.33924391
39Depression (HP:0000716)2.33881382
40Renal cortical cysts (HP:0000803)2.32431844
41Hemiplegia (HP:0002301)2.31131611
42Chronic hepatic failure (HP:0100626)2.30623548
43Abnormality of ocular smooth pursuit (HP:0000617)2.29642914
44Hyperventilation (HP:0002883)2.29161103
45Postural instability (HP:0002172)2.27027258
46Abnormality of the nasal septum (HP:0000419)2.26229217
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.26063738
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.26063738
49Urinary urgency (HP:0000012)2.23999304
50Ankle clonus (HP:0011448)2.23139626
51Aqueductal stenosis (HP:0002410)2.21812103
52Hyperkalemia (HP:0002153)2.21807603
53Dysmetria (HP:0001310)2.19641059
54Inappropriate behavior (HP:0000719)2.18958691
55Amblyopia (HP:0000646)2.18433555
56Scanning speech (HP:0002168)2.18384742
57Abnormality of the renal cortex (HP:0011035)2.18351989
58Epileptiform EEG discharges (HP:0011182)2.17040019
59Astrocytoma (HP:0009592)2.16382013
60Abnormality of the astrocytes (HP:0100707)2.16382013
61Generalized hypopigmentation of hair (HP:0011358)2.16260818
62Short chin (HP:0000331)2.14603934
63Tubulointerstitial nephritis (HP:0001970)2.14585952
64Progressive inability to walk (HP:0002505)2.13201472
65Central scotoma (HP:0000603)2.12629677
66Absent speech (HP:0001344)2.10343110
67Heterotopia (HP:0002282)2.07809889
68EEG with generalized epileptiform discharges (HP:0011198)2.05666791
69Decreased lacrimation (HP:0000633)2.04867489
70Open mouth (HP:0000194)2.03954827
71Protruding tongue (HP:0010808)2.02765968
72Truncal obesity (HP:0001956)2.01585298
73Abnormality of the lower motor neuron (HP:0002366)2.01524254
74Absent frontal sinuses (HP:0002688)2.00745221
75Alacrima (HP:0000522)2.00696606
76Gait imbalance (HP:0002141)1.99958607
77Blue irides (HP:0000635)1.99727496
78Intention tremor (HP:0002080)1.97645130
79Agitation (HP:0000713)1.95026570
80Hypsarrhythmia (HP:0002521)1.94923502
81Genital tract atresia (HP:0001827)1.93864869
82Poor coordination (HP:0002370)1.93678580
83Midline defect of the nose (HP:0004122)1.93394885
84Exotropia (HP:0000577)1.91970266
85Abnormality of the ischium (HP:0003174)1.90502014
86Abnormality of salivation (HP:0100755)1.90494677
87Bundle branch block (HP:0011710)1.90230795
88Hypothermia (HP:0002045)1.89980778
89Diplopia (HP:0000651)1.89283808
90Abnormality of binocular vision (HP:0011514)1.89283808
91Widely spaced teeth (HP:0000687)1.88736010
92Stereotypic behavior (HP:0000733)1.86140648
93Vaginal atresia (HP:0000148)1.85804735
94Hemiparesis (HP:0001269)1.85761324
95Anxiety (HP:0000739)1.84533857
96Curly hair (HP:0002212)1.83730632
97Lower limb muscle weakness (HP:0007340)1.83729136
98Pointed chin (HP:0000307)1.82774227
99Prolonged QT interval (HP:0001657)1.82242453
100Tapered finger (HP:0001182)1.81978351
101Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81433293
102Arthropathy (HP:0003040)1.80086588
103Broad palm (HP:0001169)1.78079327
104Abnormal eating behavior (HP:0100738)1.76730170
105Medial flaring of the eyebrow (HP:0010747)1.75151123
106Congenital primary aphakia (HP:0007707)1.74790470
107Papillary thyroid carcinoma (HP:0002895)1.74516923
108Obsessive-compulsive behavior (HP:0000722)1.74388884
109Deep venous thrombosis (HP:0002625)1.72677174
110Glioma (HP:0009733)1.71925537
111Prolonged partial thromboplastin time (HP:0003645)1.71025336
112Neuroendocrine neoplasm (HP:0100634)1.70789381
113Tented upper lip vermilion (HP:0010804)1.70182753
114Mutism (HP:0002300)1.70159141
115Gastroesophageal reflux (HP:0002020)1.69281585
116Bradykinesia (HP:0002067)1.68904106
117Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68700516
118Ventricular fibrillation (HP:0001663)1.68086559
119Abnormal EKG (HP:0003115)1.67759850
120Impaired vibratory sensation (HP:0002495)1.67461205
121Short foot (HP:0001773)1.67340023
122Abnormality of the pubic bones (HP:0003172)1.66872256
123Pheochromocytoma (HP:0002666)1.66222694
124Hypobetalipoproteinemia (HP:0003563)1.65085974
125Cubitus valgus (HP:0002967)1.64367110
126Megalencephaly (HP:0001355)1.63055366
127Atrial fibrillation (HP:0005110)1.62048261
128Subacute progressive viral hepatitis (HP:0006572)1.61350630
129Narrow palate (HP:0000189)1.61229389
130Enlarged kidneys (HP:0000105)1.61221359
131Absent eyebrow (HP:0002223)1.60558286
132Syncope (HP:0001279)1.60161340
133Neoplasm of the adrenal cortex (HP:0100641)1.59644849
134Primary atrial arrhythmia (HP:0001692)1.59344278
135Thick eyebrow (HP:0000574)1.59255620
136Abnormality of the renal medulla (HP:0100957)1.59020968
137Enlarged penis (HP:0000040)1.58931972
138Cutaneous finger syndactyly (HP:0010554)1.58242745
139Inability to walk (HP:0002540)1.58154684
140Cystic hygroma (HP:0000476)1.58144933
141Abnormality of the corticospinal tract (HP:0002492)1.55452145
142Decreased circulating renin level (HP:0003351)1.55132781
143Cupped ear (HP:0000378)1.54967158
144Abnormal biliary tract morphology (HP:0012440)1.54807053
145Neoplasm of the heart (HP:0100544)1.54142492
146Spastic gait (HP:0002064)1.54011115
147Amyotrophic lateral sclerosis (HP:0007354)1.53957376
148Menstrual irregularities (HP:0000858)1.53910581
149Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.53833125
150Autism (HP:0000717)1.53302375
151Intellectual disability, profound (HP:0002187)1.53204316
152Lower limb asymmetry (HP:0100559)1.52562654
153Deeply set eye (HP:0000490)1.51354799

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.46436396
2MARK13.16548292
3EPHA43.07678987
4MAP3K42.98260277
5NTRK22.54915525
6MAP3K92.52020709
7EPHA32.26110324
8MINK12.17288454
9MAP2K72.14665182
10DAPK21.87241776
11STK391.84265172
12NLK1.75914940
13CAMKK11.70791083
14RIPK41.67977212
15CAMK1G1.61263553
16SGK21.59069192
17TNIK1.55518548
18PRPF4B1.52785902
19PRKD31.52759321
20MAP2K41.52630851
21PAK61.52250339
22MAP3K21.46088751
23LATS11.45087587
24NTRK11.43583241
25PIK3CA1.43378193
26SGK31.42308903
27CDK51.40136368
28OBSCN1.40081034
29BCR1.38205349
30CASK1.37627237
31MAPK131.36710845
32MAP3K131.30867987
33KSR11.27446963
34STK381.20820075
35WNK11.20281373
36KSR21.19753553
37SGK4941.18531955
38SGK2231.18531955
39PLK21.18273910
40SIK21.18077721
41CAMKK21.17350450
42WNK31.17056229
43BMPR1B1.16499751
44WNK41.16114966
45BRD41.13807083
46STK38L1.13724564
47LMTK21.13223832
48PHKG21.12546622
49PHKG11.12546622
50CDK121.11532871
51FRK1.11294868
52INSRR1.10546198
53ACVR1B1.10022385
54RET1.09532853
55RIPK11.09510539
56PRKCH1.09213031
57PNCK1.09014867
58SGK11.04528288
59FGFR21.04440042
60FGFR41.04101339
61STK110.99680800
62FES0.97654885
63DAPK10.95550244
64FGFR30.94939435
65BRSK20.93654600
66ERBB30.93180957
67DMPK0.88698867
68MAP3K70.88639639
69CAMK1D0.88335975
70OXSR10.87407618
71CDC42BPA0.86786218
72MKNK20.85957616
73MAP3K120.85900772
74PRKAA20.82716892
75UHMK10.82586136
76GRK50.82053533
77PINK10.80751564
78FGFR10.80742547
79PRKCG0.79020849
80CAMK10.78524419
81CSNK1G10.78061029
82PAK30.76069397
83CSNK1A1L0.75115133
84CAMK2A0.74703857
85ALK0.74642590
86MARK20.74272147
87SCYL20.73515796
88PTK2B0.72521159
89PDK10.72151684
90MET0.71274222
91ERBB20.69339103
92GRK70.65856937
93EIF2AK30.65250007
94YES10.64663101
95TYRO30.63303156
96TAOK10.62780260
97NEK60.62388333
98RPS6KA30.61819884
99DYRK1A0.61289846
100FER0.59696671
101CSNK1G20.58549024
102MAP4K20.57388042
103RPS6KA20.56754271
104PRKCE0.56159485
105CAMK2B0.55248665
106TNK20.55194764
107CAMK40.55162796
108PDGFRA0.54965226
109PKN20.54920188
110MAPK100.51988785
111NEK90.51504619
112CSNK1D0.50896153
113PDGFRB0.49921317
114MAP3K60.49611096
115AKT30.48899968
116PRKG10.48501295
117MAP3K10.47586586
118CSNK1E0.47544438
119PDPK10.47241026
120PRKCB0.46934462
121FYN0.46387237
122MAPK80.45375337
123TRPM70.41408275
124CDK180.39779805
125MAP2K60.38732129
126GSK3B0.38083938
127CAMK2D0.37783204
128STK30.37405781
129PRKCZ0.37162780
130JAK10.36301178
131CDK150.36148205
132STK240.36010945
133LATS20.35953883
134PRKAA10.35523034
135PKN10.35440437
136RPS6KB10.35428637
137CDK30.33988392

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.84736263
2Circadian entrainment_Homo sapiens_hsa047132.49152372
3Olfactory transduction_Homo sapiens_hsa047402.31567073
4Long-term potentiation_Homo sapiens_hsa047202.30133268
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23187294
6Morphine addiction_Homo sapiens_hsa050322.20279598
7GABAergic synapse_Homo sapiens_hsa047272.17792591
8Glutamatergic synapse_Homo sapiens_hsa047242.17700767
9Synaptic vesicle cycle_Homo sapiens_hsa047212.12617487
10Amphetamine addiction_Homo sapiens_hsa050312.02553240
11Fatty acid biosynthesis_Homo sapiens_hsa000611.90108512
12Insulin secretion_Homo sapiens_hsa049111.87964635
13Dopaminergic synapse_Homo sapiens_hsa047281.87720964
14Salivary secretion_Homo sapiens_hsa049701.87656858
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80677889
16Cholinergic synapse_Homo sapiens_hsa047251.77500650
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70818511
18Gastric acid secretion_Homo sapiens_hsa049711.70157186
19Renin secretion_Homo sapiens_hsa049241.70087926
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.64731426
21Taste transduction_Homo sapiens_hsa047421.63647316
22ABC transporters_Homo sapiens_hsa020101.63238933
23Oxytocin signaling pathway_Homo sapiens_hsa049211.59510302
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56397528
25Long-term depression_Homo sapiens_hsa047301.50741259
26Type II diabetes mellitus_Homo sapiens_hsa049301.49341998
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49131455
28Calcium signaling pathway_Homo sapiens_hsa040201.43608811
29Serotonergic synapse_Homo sapiens_hsa047261.41372246
30Butanoate metabolism_Homo sapiens_hsa006501.39156995
31Cocaine addiction_Homo sapiens_hsa050301.38094547
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35392962
33cAMP signaling pathway_Homo sapiens_hsa040241.33516836
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.32126964
35GnRH signaling pathway_Homo sapiens_hsa049121.31902017
36Estrogen signaling pathway_Homo sapiens_hsa049151.30394450
37Dorso-ventral axis formation_Homo sapiens_hsa043201.26174772
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.25618984
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.25265819
40Lysine degradation_Homo sapiens_hsa003101.21110996
41Glioma_Homo sapiens_hsa052141.21048701
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.19565408
43Gap junction_Homo sapiens_hsa045401.16016028
44Complement and coagulation cascades_Homo sapiens_hsa046101.12558633
45Dilated cardiomyopathy_Homo sapiens_hsa054141.12093157
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09751024
47Axon guidance_Homo sapiens_hsa043601.06785304
48Melanogenesis_Homo sapiens_hsa049161.03708649
49Vitamin B6 metabolism_Homo sapiens_hsa007501.01604003
50ErbB signaling pathway_Homo sapiens_hsa040120.99704645
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.99435438
52Phototransduction_Homo sapiens_hsa047440.94682975
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94454844
54Pancreatic secretion_Homo sapiens_hsa049720.93432559
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.91133678
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90005563
57Steroid biosynthesis_Homo sapiens_hsa001000.89099294
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87366211
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.86808778
60MAPK signaling pathway_Homo sapiens_hsa040100.86320010
61Thyroid hormone synthesis_Homo sapiens_hsa049180.86304743
62Histidine metabolism_Homo sapiens_hsa003400.85476302
63Choline metabolism in cancer_Homo sapiens_hsa052310.84954951
64Fatty acid metabolism_Homo sapiens_hsa012120.84733015
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84335665
66Bile secretion_Homo sapiens_hsa049760.84290611
67Adherens junction_Homo sapiens_hsa045200.83971400
68mTOR signaling pathway_Homo sapiens_hsa041500.82636997
69Circadian rhythm_Homo sapiens_hsa047100.81998346
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81927961
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81218291
72Propanoate metabolism_Homo sapiens_hsa006400.80184582
73Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79701686
74Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78698225
75AMPK signaling pathway_Homo sapiens_hsa041520.78490473
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77158062
77Endometrial cancer_Homo sapiens_hsa052130.77077353
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.76044568
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74620596
80Inositol phosphate metabolism_Homo sapiens_hsa005620.74560130
81Glucagon signaling pathway_Homo sapiens_hsa049220.74142048
82Oocyte meiosis_Homo sapiens_hsa041140.73791284
83Nitrogen metabolism_Homo sapiens_hsa009100.72479670
84Rap1 signaling pathway_Homo sapiens_hsa040150.72419952
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71284608
86Regulation of autophagy_Homo sapiens_hsa041400.70557432
87Tight junction_Homo sapiens_hsa045300.69224780
88Collecting duct acid secretion_Homo sapiens_hsa049660.68462346
89Ras signaling pathway_Homo sapiens_hsa040140.67880303
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.67084721
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66885996
92Non-small cell lung cancer_Homo sapiens_hsa052230.66831877
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63566188
94Chemokine signaling pathway_Homo sapiens_hsa040620.63037546
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62803114
96VEGF signaling pathway_Homo sapiens_hsa043700.61985572
97Hippo signaling pathway_Homo sapiens_hsa043900.61950780
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61533515
99PPAR signaling pathway_Homo sapiens_hsa033200.61414275
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59951757
101Fatty acid degradation_Homo sapiens_hsa000710.59880497
102Glycerolipid metabolism_Homo sapiens_hsa005610.59080115
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58950485
104TGF-beta signaling pathway_Homo sapiens_hsa043500.58398561
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.58067336
106Wnt signaling pathway_Homo sapiens_hsa043100.57020228
107Ether lipid metabolism_Homo sapiens_hsa005650.56863065
108Sphingolipid metabolism_Homo sapiens_hsa006000.56554168
109Platelet activation_Homo sapiens_hsa046110.56163841
110Insulin signaling pathway_Homo sapiens_hsa049100.55826530
111Colorectal cancer_Homo sapiens_hsa052100.54519370
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.54473888
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53478336
114Prolactin signaling pathway_Homo sapiens_hsa049170.53335715
115Renal cell carcinoma_Homo sapiens_hsa052110.53219646
116Cardiac muscle contraction_Homo sapiens_hsa042600.53150850
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.52606677
118Vibrio cholerae infection_Homo sapiens_hsa051100.52087509
119Type I diabetes mellitus_Homo sapiens_hsa049400.51041198
120Alcoholism_Homo sapiens_hsa050340.50207085
121Ovarian steroidogenesis_Homo sapiens_hsa049130.49197540
122Endocytosis_Homo sapiens_hsa041440.48319531
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48005325
124Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46448577
125Focal adhesion_Homo sapiens_hsa045100.45790462
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44503885
127B cell receptor signaling pathway_Homo sapiens_hsa046620.44414114
128Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44089818
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43176841
130T cell receptor signaling pathway_Homo sapiens_hsa046600.42452067
131Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42367874
132FoxO signaling pathway_Homo sapiens_hsa040680.42323448
133Insulin resistance_Homo sapiens_hsa049310.41549084

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