RALA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endothelium development (GO:0003158)5.87034432
2pyrimidine nucleobase catabolic process (GO:0006208)5.03932624
3layer formation in cerebral cortex (GO:0021819)4.84870140
4cell adhesion mediated by integrin (GO:0033627)4.46943955
5neuron recognition (GO:0008038)4.39251654
6establishment of mitochondrion localization (GO:0051654)4.36158860
7dendritic spine morphogenesis (GO:0060997)4.33417880
8cell migration in hindbrain (GO:0021535)4.26973112
9axonal fasciculation (GO:0007413)4.26472241
10retina vasculature morphogenesis in camera-type eye (GO:0061299)4.25754345
11synaptic vesicle maturation (GO:0016188)4.06139448
12nucleobase catabolic process (GO:0046113)4.05964814
13establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.04125628
14mitochondrion transport along microtubule (GO:0047497)4.04125628
15negative regulation of microtubule polymerization (GO:0031115)4.03145550
16proteasome assembly (GO:0043248)3.97002379
17neuron cell-cell adhesion (GO:0007158)3.95177184
18dendrite morphogenesis (GO:0048813)3.94515191
19substrate-dependent cell migration (GO:0006929)3.93036086
20regulation of glomerular filtration (GO:0003093)3.78573395
21establishment of integrated proviral latency (GO:0075713)3.75002653
22axon extension (GO:0048675)3.70918325
23chondrocyte proliferation (GO:0035988)3.70463246
24blood vessel maturation (GO:0001955)3.69442409
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67559209
26negative regulation of nitric-oxide synthase activity (GO:0051001)3.59543169
27establishment of viral latency (GO:0019043)3.59441451
28protein retention in ER lumen (GO:0006621)3.57686383
29regulation of mononuclear cell migration (GO:0071675)3.53637239
30protein localization to endosome (GO:0036010)3.53427762
31positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.49505472
32negative regulation of catenin import into nucleus (GO:0035414)3.47464979
33wound healing, spreading of epidermal cells (GO:0035313)3.44970697
34COPI coating of Golgi vesicle (GO:0048205)3.44144992
35Golgi transport vesicle coating (GO:0048200)3.44144992
36negative regulation of axon guidance (GO:1902668)3.41998751
37regulation of short-term neuronal synaptic plasticity (GO:0048172)3.41217161
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.40867218
39synaptic vesicle exocytosis (GO:0016079)3.38124331
40neuron projection extension (GO:1990138)3.33043264
41ribosomal large subunit biogenesis (GO:0042273)3.28267271
42central nervous system projection neuron axonogenesis (GO:0021952)3.28167859
43cerebral cortex radially oriented cell migration (GO:0021799)3.26753108
44protein maturation by protein folding (GO:0022417)3.26079867
45vocalization behavior (GO:0071625)3.25060339
46gap junction assembly (GO:0016264)3.24346360
47regulation of synaptic vesicle exocytosis (GO:2000300)3.22510678
48organelle transport along microtubule (GO:0072384)3.22144875
49negative regulation of focal adhesion assembly (GO:0051895)3.21944253
50negative regulation of cell junction assembly (GO:1901889)3.21944253
51negative regulation of adherens junction organization (GO:1903392)3.21944253
52cellular copper ion homeostasis (GO:0006878)3.20874980
53glutamate secretion (GO:0014047)3.19991216
54protein localization to synapse (GO:0035418)3.18398840
55positive regulation of axon extension (GO:0045773)3.18081665
56endodermal cell differentiation (GO:0035987)3.15760324
57regulation of axon guidance (GO:1902667)3.14842884
58regulation of synapse structural plasticity (GO:0051823)3.06001168
59vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.01483133
60negative regulation of axon extension involved in axon guidance (GO:0048843)3.00030456
61regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.99916069
62negative regulation of blood vessel endothelial cell migration (GO:0043537)2.99195848
63exploration behavior (GO:0035640)2.95700127
64skin morphogenesis (GO:0043589)2.95632748
65endothelial tube morphogenesis (GO:0061154)2.94250588
66morphogenesis of an endothelium (GO:0003159)2.94250588
67regulation of axon extension (GO:0030516)2.94051377
68axon cargo transport (GO:0008088)2.93360428
69regulation of microtubule polymerization (GO:0031113)2.93353481
70negative regulation of axon extension (GO:0030517)2.93229981
71virion attachment to host cell (GO:0019062)2.91689397
72adhesion of symbiont to host cell (GO:0044650)2.91689397
73endothelial cell morphogenesis (GO:0001886)2.91589587
74cell migration involved in sprouting angiogenesis (GO:0002042)2.91082636
75regulation of fever generation (GO:0031620)2.88622558
76negative regulation of cardiac muscle tissue growth (GO:0055022)2.86367372
77negative regulation of heart growth (GO:0061117)2.86367372
78regulation of axon extension involved in axon guidance (GO:0048841)2.86041125
79regulation of vitamin D biosynthetic process (GO:0060556)2.85011107
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84233179
81negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.83994638
82cerebral cortex neuron differentiation (GO:0021895)2.83152073
83hyaluronan catabolic process (GO:0030214)2.82930673
84dendritic spine organization (GO:0097061)2.82281031
85lymphangiogenesis (GO:0001946)2.80752210
86innervation (GO:0060384)2.79477625
87protein complex localization (GO:0031503)2.79086186
88negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78227509
89negative regulation of axonogenesis (GO:0050771)2.78132090
90chronic inflammatory response (GO:0002544)2.76325068
91negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72696023
92cellular protein complex localization (GO:0034629)2.71000061
93regulation of macrophage chemotaxis (GO:0010758)2.70664643
94mating behavior (GO:0007617)2.69795875
95regulation of early endosome to late endosome transport (GO:2000641)2.69622977
96neurofilament cytoskeleton organization (GO:0060052)2.69437556
97limb bud formation (GO:0060174)2.69159076
98nucleobase-containing small molecule interconversion (GO:0015949)2.69158064
99regulation of dendritic spine morphogenesis (GO:0061001)2.68838188
100regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.68758168
101positive regulation of synapse assembly (GO:0051965)2.68125541
102hippocampus development (GO:0021766)2.67779952
103central nervous system neuron axonogenesis (GO:0021955)2.66205471
104glial cell migration (GO:0008347)2.65998992
105chaperone-mediated protein transport (GO:0072321)2.65737258
106positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65499908
107clathrin coat assembly (GO:0048268)2.65198912
108negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.64648160
109regulation of synaptic vesicle transport (GO:1902803)2.64318462
110negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.63933496
111negative regulation of ligase activity (GO:0051352)2.63933496
112stress fiber assembly (GO:0043149)2.63073041
113regulation of extent of cell growth (GO:0061387)2.62424795
114negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.62074839
115negative regulation of monooxygenase activity (GO:0032769)2.60668534
116ionotropic glutamate receptor signaling pathway (GO:0035235)2.60404305
117positive regulation of synapse maturation (GO:0090129)2.60180568
118developmental cell growth (GO:0048588)2.59571363
119synapse assembly (GO:0007416)2.59140782
120mitotic metaphase plate congression (GO:0007080)2.58593500
121locomotory exploration behavior (GO:0035641)2.58564826
122regulation of vesicle fusion (GO:0031338)2.58345450
123monocyte chemotaxis (GO:0002548)2.57996263
124ganglion development (GO:0061548)2.57872739
125regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57057614
126paraxial mesoderm development (GO:0048339)2.56909318
127vesicle transport along microtubule (GO:0047496)2.56546492
128dendrite development (GO:0016358)2.56157499
129neuron projection morphogenesis (GO:0048812)2.56046696
130formation of translation preinitiation complex (GO:0001731)2.55934540
131positive regulation of p38MAPK cascade (GO:1900745)2.55884900
132regulation of glutamate receptor signaling pathway (GO:1900449)2.55623446
133mitotic nuclear envelope reassembly (GO:0007084)2.55373910
134nuclear envelope reassembly (GO:0031468)2.55373910
135apical protein localization (GO:0045176)2.54328023
136axon ensheathment in central nervous system (GO:0032291)2.54322549
137central nervous system myelination (GO:0022010)2.54322549
138barbed-end actin filament capping (GO:0051016)2.53623913
139copper ion homeostasis (GO:0055070)2.53589615
140* positive regulation of filopodium assembly (GO:0051491)2.53463482
141proline transport (GO:0015824)2.53365441
142retinal ganglion cell axon guidance (GO:0031290)2.52665179
143ribonucleoprotein complex disassembly (GO:0032988)2.52448083
144vascular endothelial growth factor signaling pathway (GO:0038084)2.51266448
145cell fate commitment involved in formation of primary germ layer (GO:0060795)2.50436208
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.50053823
147axon extension involved in axon guidance (GO:0048846)2.50053823
148regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.50002429
149photoreceptor cell differentiation (GO:0046530)2.49986013
150eye photoreceptor cell differentiation (GO:0001754)2.49986013
151de novo protein folding (GO:0006458)2.49892539
152SMAD protein complex assembly (GO:0007183)2.49758619
153synapse organization (GO:0050808)2.49695786
154axonogenesis (GO:0007409)2.49532842
155lipopolysaccharide biosynthetic process (GO:0009103)2.48812527
156postsynaptic membrane organization (GO:0001941)2.47908514
157response to nerve growth factor (GO:1990089)2.47715511
158cellular response to nerve growth factor stimulus (GO:1990090)2.47715511
159cyclooxygenase pathway (GO:0019371)2.47112841
160ephrin receptor signaling pathway (GO:0048013)2.46582592
161endothelial cell proliferation (GO:0001935)2.45686128
162glutamate receptor signaling pathway (GO:0007215)2.45202306
163positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.45063591
164artery development (GO:0060840)2.42965208
165protein localization to kinetochore (GO:0034501)2.42767166
166detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.42363672
167detection of temperature stimulus involved in sensory perception (GO:0050961)2.42363672
168presynaptic membrane assembly (GO:0097105)2.42229761
169positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.41692134
170hemidesmosome assembly (GO:0031581)2.41431822
171substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.41291688
172substrate-independent telencephalic tangential migration (GO:0021826)2.41291688
173membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.41169598
174regulation of dendritic spine development (GO:0060998)2.39901446
175regulation of long-term neuronal synaptic plasticity (GO:0048169)2.39617676
176activation of protein kinase A activity (GO:0034199)2.39380364
177positive regulation of protein depolymerization (GO:1901881)2.39151625
178neuron migration (GO:0001764)2.38531090
179positive regulation of potassium ion transmembrane transport (GO:1901381)2.38339463
180glycosphingolipid catabolic process (GO:0046479)2.37848436
181regulation of neuron migration (GO:2001222)2.37579690
182regulation of neuronal synaptic plasticity (GO:0048168)2.36353532
183renal system process involved in regulation of blood volume (GO:0001977)2.35924549
184de novo posttranslational protein folding (GO:0051084)2.35922123
185membrane assembly (GO:0071709)2.35668301
186cerebellar Purkinje cell layer development (GO:0021680)2.35560864
187transmission of nerve impulse (GO:0019226)2.35288825
188endocytic recycling (GO:0032456)2.35205650
189regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.35157473
190semaphorin-plexin signaling pathway (GO:0071526)2.34669491
191regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.34280080
192wound healing, spreading of cells (GO:0044319)2.33858908
193sprouting angiogenesis (GO:0002040)2.33151751
194cellular response to arsenic-containing substance (GO:0071243)2.32459895
195regulation of membrane protein ectodomain proteolysis (GO:0051043)2.32385826
196organelle disassembly (GO:1903008)2.30818038
197activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.28880895
198heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.28531856
199apoptotic cell clearance (GO:0043277)2.28327784
200outer ear morphogenesis (GO:0042473)2.28251801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.48465312
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.63814018
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.22267144
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21862925
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.92889514
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87782276
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77334453
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.71478763
9CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65324380
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61264116
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61264116
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.57775523
13TRIM28_21343339_ChIP-Seq_HEK293_Human2.54433614
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.51576135
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49980597
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.48217439
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45836161
18CLOCK_20551151_ChIP-Seq_293T_Human2.44370495
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.41184785
20KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38239706
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.38002834
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37918451
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37523433
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29858892
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25152957
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.23024997
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.22465948
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20522093
29EED_16625203_ChIP-ChIP_MESCs_Mouse2.17624941
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14814406
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.12311713
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12282486
33GBX2_23144817_ChIP-Seq_PC3_Human2.10560550
34HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10427148
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.08945219
36SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08259050
37* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07129697
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.05726267
39ZFX_18555785_ChIP-Seq_MESCs_Mouse2.05381455
40RNF2_27304074_Chip-Seq_ESCs_Mouse2.04743535
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.04658180
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.04658180
43KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.04658180
44EGR1_19374776_ChIP-ChIP_THP-1_Human2.04472170
45RBPJ_22232070_ChIP-Seq_NCS_Mouse2.02396395
46JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01248506
47* GABP_17652178_ChIP-ChIP_JURKAT_Human1.96820748
48AR_21909140_ChIP-Seq_LNCAP_Human1.95288694
49PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.91901231
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86852975
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.86675592
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85673435
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85087262
54ELK1_19687146_ChIP-ChIP_HELA_Human1.82778144
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.82682549
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81807259
57DCP1A_22483619_ChIP-Seq_HELA_Human1.81621226
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78155738
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73902487
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73501276
61KLF4_18555785_ChIP-Seq_MESCs_Mouse1.72481666
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72229529
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69465603
64ETS1_20019798_ChIP-Seq_JURKAT_Human1.69277478
65WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68813070
66WT1_19549856_ChIP-ChIP_CCG9911_Human1.66843003
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64327302
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.62759575
69AR_21572438_ChIP-Seq_LNCaP_Human1.62361392
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.61443281
71REST_21632747_ChIP-Seq_MESCs_Mouse1.59132463
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59048907
73TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.58778798
74ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56777089
75PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.55754392
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.55376531
77EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.55010296
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.53293068
79* RING1B_27294783_Chip-Seq_ESCs_Mouse1.51916764
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51502133
81NANOG_18692474_ChIP-Seq_MEFs_Mouse1.50979368
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50883349
83ZNF274_21170338_ChIP-Seq_K562_Hela1.49565656
84ZNF263_19887448_ChIP-Seq_K562_Human1.48491019
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45320377
86* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.45040615
87SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.44708833
88SOX2_18692474_ChIP-Seq_MEFs_Mouse1.44292300
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42836552
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42018522
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.41765687
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.41426262
93OCT4_18692474_ChIP-Seq_MEFs_Mouse1.39678342
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.38829645
95SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.38502969
96SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.38502969
97TFEB_21752829_ChIP-Seq_HELA_Human1.38237272
98ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.35351476
99IGF1R_20145208_ChIP-Seq_DFB_Human1.35242128
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34491144
101* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34476776
102PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33269854
103TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32864408
104DROSHA_22980978_ChIP-Seq_HELA_Human1.32712580
105NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32344603
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.32158424
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31089445
108ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30987232
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30218186
110RNF2_27304074_Chip-Seq_NSC_Mouse1.29698166
111PIAS1_25552417_ChIP-Seq_VCAP_Human1.29419980
112FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29412512
113TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29091002
114XRN2_22483619_ChIP-Seq_HELA_Human1.27956919
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.27738121
116EST1_17652178_ChIP-ChIP_JURKAT_Human1.27230958
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25512131
118TAF15_26573619_Chip-Seq_HEK293_Human1.25375514
119HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25275071
120FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24246722
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24183184
122NANOG_18555785_ChIP-Seq_MESCs_Mouse1.23725188
123KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23708067
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23671975
125PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23638902
126IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23587007
127TP53_18474530_ChIP-ChIP_U2OS_Human1.23253319
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.21776318
129TTF2_22483619_ChIP-Seq_HELA_Human1.20706294
130SOX17_20123909_ChIP-Seq_XEN_Mouse1.20322434
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20169712
132REST_18959480_ChIP-ChIP_MESCs_Mouse1.19785308
133SALL4_18804426_ChIP-ChIP_XEN_Mouse1.18768918
134EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.18435686
135E2F7_22180533_ChIP-Seq_HELA_Human1.16954150
136AHR_22903824_ChIP-Seq_MCF-7_Human1.16789922
137BRD4_25478319_ChIP-Seq_HGPS_Human1.16763029
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16743040
139CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16441956
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14919092
141ELK1_22589737_ChIP-Seq_MCF10A_Human1.14778183
142EP300_21415370_ChIP-Seq_HL-1_Mouse1.14279744
143HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14086587
144ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13945442
145SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13033504
146NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12815835
147P300_19829295_ChIP-Seq_ESCs_Human1.12565307
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10498814
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09879251
150ERG_21242973_ChIP-ChIP_JURKAT_Human1.09872957
151ARNT_22903824_ChIP-Seq_MCF-7_Human1.09228324
152* UBF1/2_26484160_Chip-Seq_HMECs_Human1.09189629
153KDM2B_26808549_Chip-Seq_K562_Human1.09082901
154NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.08923129
155CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08189790
156GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.07489169
157SOX2_21211035_ChIP-Seq_LN229_Gbm1.06572858
158* GABP_19822575_ChIP-Seq_HepG2_Human1.06438153
159* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05447151
160ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05373300
161CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05370934
162EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05084497
163WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04355567
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04178713
165OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02788428
166TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02766780
167VDR_22108803_ChIP-Seq_LS180_Human1.02168881
168YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02056483
169P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00617657
170SMAD4_21799915_ChIP-Seq_A2780_Human0.98100421
171ESR1_20079471_ChIP-ChIP_T-47D_Human0.95461792
172STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95140367
173FUS_26573619_Chip-Seq_HEK293_Human0.94939862
174SMAD4_21741376_ChIP-Seq_HESCs_Human0.94437678
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93444404
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.92958004
177ER_23166858_ChIP-Seq_MCF-7_Human0.92833030
178ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90691921
179TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90605071
180* AR_25329375_ChIP-Seq_VCAP_Human0.90383943
181TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90122321
182ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87299853
183NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87279238
184NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87279238
185* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87017753
186JUN_21703547_ChIP-Seq_K562_Human0.86722870
187TP53_16413492_ChIP-PET_HCT116_Human0.86376623
188PRDM14_20953172_ChIP-Seq_ESCs_Human0.85618890
189TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.85217756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system3.96987706
2MP0004272_abnormal_basement_membrane3.67700352
3MP0003941_abnormal_skin_development3.58034153
4MP0006054_spinal_hemorrhage3.55758663
5MP0004859_abnormal_synaptic_plasticity3.49920972
6MP0008438_abnormal_cutaneous_collagen3.32901660
7MP0003880_abnormal_central_pattern3.26094571
8MP0004270_analgesia3.08908514
9MP0000778_abnormal_nervous_system3.00935291
10MP0003705_abnormal_hypodermis_morpholog2.80838399
11MP0002877_abnormal_melanocyte_morpholog2.75787510
12MP0003279_aneurysm2.73376353
13MP0003635_abnormal_synaptic_transmissio2.56347881
14MP0004858_abnormal_nervous_system2.39798528
15MP0009840_abnormal_foam_cell2.37245676
16MP0002254_reproductive_system_inflammat2.29243130
17MP0005058_abnormal_lysosome_morphology2.27753579
18MP0000537_abnormal_urethra_morphology2.27652159
19MP0003329_amyloid_beta_deposits2.26180719
20MP0001879_abnormal_lymphatic_vessel2.17796970
21MP0001542_abnormal_bone_strength2.17542079
22MP0002184_abnormal_innervation2.17191015
23MP0002063_abnormal_learning/memory/cond2.16411764
24MP0010234_abnormal_vibrissa_follicle2.15321290
25MP0003566_abnormal_cell_adhesion2.14265894
26MP0005423_abnormal_somatic_nervous2.11103368
27MP0002734_abnormal_mechanical_nocicepti2.05956245
28MP0006276_abnormal_autonomic_nervous2.01554107
29MP0009379_abnormal_foot_pigmentation2.00189476
30MP0010352_gastrointestinal_tract_polyps1.96025501
31MP0003453_abnormal_keratinocyte_physiol1.86123340
32MP0004957_abnormal_blastocyst_morpholog1.85572224
33MP0002733_abnormal_thermal_nociception1.85227903
34MP0001968_abnormal_touch/_nociception1.85167335
35MP0005623_abnormal_meninges_morphology1.84027387
36MP0000343_altered_response_to1.77477610
37MP0005501_abnormal_skin_physiology1.75782001
38MP0003950_abnormal_plasma_membrane1.74887424
39MP0004510_myositis1.74539017
40MP0003806_abnormal_nucleotide_metabolis1.67714008
41MP0001348_abnormal_lacrimal_gland1.66126185
42MP0001486_abnormal_startle_reflex1.64942384
43MP0002064_seizures1.61463562
44MP0000955_abnormal_spinal_cord1.61381881
45MP0001853_heart_inflammation1.60752039
46MP0009745_abnormal_behavioral_response1.59706489
47MP0009384_cardiac_valve_regurgitation1.57907804
48MP0005248_abnormal_Harderian_gland1.57057584
49MP0003186_abnormal_redox_activity1.56640885
50MP0000767_abnormal_smooth_muscle1.56070783
51MP0002909_abnormal_adrenal_gland1.55740750
52MP0005275_abnormal_skin_tensile1.54973473
53MP0001299_abnormal_eye_distance/1.54079326
54MP0002735_abnormal_chemical_nociception1.53276957
55MP0002572_abnormal_emotion/affect_behav1.52435472
56MP0008932_abnormal_embryonic_tissue1.50150865
57MP0000750_abnormal_muscle_regeneration1.49964628
58MP0005167_abnormal_blood-brain_barrier1.49164485
59MP0005023_abnormal_wound_healing1.49008861
60MP0001440_abnormal_grooming_behavior1.48173683
61MP0004811_abnormal_neuron_physiology1.46667375
62MP0003385_abnormal_body_wall1.46393221
63MP0003448_altered_tumor_morphology1.45261890
64MP0005197_abnormal_uvea_morphology1.43042917
65MP0002882_abnormal_neuron_morphology1.42912387
66MP0005187_abnormal_penis_morphology1.41617133
67MP0004782_abnormal_surfactant_physiolog1.40501661
68MP0001970_abnormal_pain_threshold1.38415701
69MP0002557_abnormal_social/conspecific_i1.37755196
70MP0005165_increased_susceptibility_to1.35672223
71MP0005595_abnormal_vascular_smooth1.35333735
72MP0001915_intracranial_hemorrhage1.34459171
73MP0002234_abnormal_pharynx_morphology1.34354591
74MP0003693_abnormal_embryo_hatching1.33154336
75MP0008004_abnormal_stomach_pH1.32810640
76MP0009780_abnormal_chondrocyte_physiolo1.31411473
77MP0002736_abnormal_nociception_after1.29466860
78MP0003861_abnormal_nervous_system1.28193450
79MP0003191_abnormal_cellular_cholesterol1.27614067
80MP0002102_abnormal_ear_morphology1.27185348
81MP0002152_abnormal_brain_morphology1.26044366
82MP0001849_ear_inflammation1.25686485
83MP0003828_pulmonary_edema1.24709344
84MP0004924_abnormal_behavior1.23661010
85MP0005386_behavior/neurological_phenoty1.23661010
86MP0004885_abnormal_endolymph1.23205515
87MP0002272_abnormal_nervous_system1.22285509
88MP0009250_abnormal_appendicular_skeleto1.21143547
89MP0000462_abnormal_digestive_system1.21068260
90MP0002067_abnormal_sensory_capabilities1.20162213
91MP0003091_abnormal_cell_migration1.19097046
92MP0003119_abnormal_digestive_system1.17295816
93MP0002295_abnormal_pulmonary_circulatio1.16354546
94MP0009046_muscle_twitch1.15527668
95MP0009697_abnormal_copulation1.14975151
96MP0000858_altered_metastatic_potential1.14535555
97MP0000579_abnormal_nail_morphology1.14229747
98MP0003634_abnormal_glial_cell1.14145429
99MP0003300_gastrointestinal_ulcer1.13067444
100MP0003137_abnormal_impulse_conducting1.12128859
101MP0005508_abnormal_skeleton_morphology1.11358656
102MP0001730_embryonic_growth_arrest1.10981601
103MP0003303_peritoneal_inflammation1.10559132
104MP0001293_anophthalmia1.10537876
105MP0001243_abnormal_dermal_layer1.09915593
106MP0005367_renal/urinary_system_phenotyp1.09543043
107MP0000516_abnormal_urinary_system1.09543043
108MP0001216_abnormal_epidermal_layer1.09126586
109MP0002066_abnormal_motor_capabilities/c1.08894246
110MP0000920_abnormal_myelination1.06687860
111MP0003755_abnormal_palate_morphology1.05809071
112MP0004233_abnormal_muscle_weight1.05426785
113MP0001984_abnormal_olfaction1.04630225
114MP0002752_abnormal_somatic_nervous1.03597141
115MP0003942_abnormal_urinary_system1.02806084
116MP0003221_abnormal_cardiomyocyte_apopto1.02112252
117MP0003938_abnormal_ear_development1.00040717
118MP0008789_abnormal_olfactory_epithelium0.99743916
119MP0004742_abnormal_vestibular_system0.99397650
120MP0000751_myopathy0.98689786
121MP0003937_abnormal_limbs/digits/tail_de0.98332010
122MP0002653_abnormal_ependyma_morphology0.97402524
123MP0002092_abnormal_eye_morphology0.96701264
124MP0001727_abnormal_embryo_implantation0.96353079
125MP0002060_abnormal_skin_morphology0.95512042
126MP0003122_maternal_imprinting0.94623387
127MP0004145_abnormal_muscle_electrophysio0.94433103
128MP0006082_CNS_inflammation0.94116177
129MP0008007_abnormal_cellular_replicative0.93107764
130MP0009053_abnormal_anal_canal0.92838010
131MP0000534_abnormal_ureter_morphology0.92685356
132MP0000604_amyloidosis0.92337130
133MP0010030_abnormal_orbit_morphology0.91728413
134MP0003718_maternal_effect0.90428576
135MP0001340_abnormal_eyelid_morphology0.88214620
136MP0004142_abnormal_muscle_tone0.87636046
137MP0002837_dystrophic_cardiac_calcinosis0.86903586
138MP0000647_abnormal_sebaceous_gland0.86071082
139MP0004215_abnormal_myocardial_fiber0.85759827
140MP0000569_abnormal_digit_pigmentation0.85441192
141MP0002896_abnormal_bone_mineralization0.85126443
142MP0002697_abnormal_eye_size0.84373320
143MP0001672_abnormal_embryogenesis/_devel0.82659777
144MP0005380_embryogenesis_phenotype0.82659777
145MP0000428_abnormal_craniofacial_morphol0.82321895
146MP0001529_abnormal_vocalization0.82201645
147MP0002751_abnormal_autonomic_nervous0.82037106
148MP0000358_abnormal_cell_content/0.82011570
149MP0002282_abnormal_trachea_morphology0.81828613
150MP0002998_abnormal_bone_remodeling0.81563949
151MP0004130_abnormal_muscle_cell0.81447264
152MP0000013_abnormal_adipose_tissue0.81250642
153MP0003315_abnormal_perineum_morphology0.81166185
154MP0001191_abnormal_skin_condition0.80842512
155MP0010386_abnormal_urinary_bladder0.80334280
156MP0002233_abnormal_nose_morphology0.79349380
157MP0000350_abnormal_cell_proliferation0.79197374
158MP0002085_abnormal_embryonic_tissue0.78078853
159MP0005193_abnormal_anterior_eye0.77836207
160MP0000762_abnormal_tongue_morphology0.77158548
161MP0003984_embryonic_growth_retardation0.77030675
162MP0000538_abnormal_urinary_bladder0.76987749
163MP0002081_perinatal_lethality0.76434390
164MP0005257_abnormal_intraocular_pressure0.76125279
165MP0000490_abnormal_crypts_of0.75908024
166MP0001614_abnormal_blood_vessel0.75479599
167MP0002148_abnormal_hypersensitivity_rea0.75206477
168MP0004133_heterotaxia0.74896440
169MP0000026_abnormal_inner_ear0.74779892
170MP0002796_impaired_skin_barrier0.74775417
171MP0002116_abnormal_craniofacial_bone0.74496643
172MP0000049_abnormal_middle_ear0.74298629
173MP0004185_abnormal_adipocyte_glucose0.74208602
174MP0010771_integument_phenotype0.73042541
175MP0001177_atelectasis0.72880317
176MP0002088_abnormal_embryonic_growth/wei0.72455416
177MP0003075_altered_response_to0.70485180
178MP0002084_abnormal_developmental_patter0.69955744
179MP0003935_abnormal_craniofacial_develop0.69470036

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.61052045
2Abnormality of liposaccharide metabolism (HP:0010968)4.61052045
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.61052045
4Premature rupture of membranes (HP:0001788)4.36906636
5Tetraparesis (HP:0002273)4.31457582
6Termporal pattern (HP:0011008)4.05543420
7Insidious onset (HP:0003587)4.05543420
8Neurofibrillary tangles (HP:0002185)3.99699125
9Protrusio acetabuli (HP:0003179)3.91449851
10Cerebral inclusion bodies (HP:0100314)3.76555661
11Myokymia (HP:0002411)3.52386915
12Megalencephaly (HP:0001355)3.49180730
13Mutism (HP:0002300)3.41392736
14Limb dystonia (HP:0002451)3.38598604
15Abnormality of the corticospinal tract (HP:0002492)3.37551976
16Supranuclear gaze palsy (HP:0000605)3.34936975
17Ankle clonus (HP:0011448)3.32436672
18Selective tooth agenesis (HP:0001592)3.01630751
19Ankle contracture (HP:0006466)2.92950021
20Atrophic scars (HP:0001075)2.86529820
21Fragile nails (HP:0001808)2.82933482
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.81464395
23Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.81464395
24Amyotrophic lateral sclerosis (HP:0007354)2.80445380
25Visual hallucinations (HP:0002367)2.77351164
26Short middle phalanx of the 5th finger (HP:0004220)2.76082993
27Vertebral compression fractures (HP:0002953)2.70926919
28Urinary urgency (HP:0000012)2.68913676
29Pheochromocytoma (HP:0002666)2.68295519
30Akinesia (HP:0002304)2.66720694
31Hepatoblastoma (HP:0002884)2.65904004
32Spinal rigidity (HP:0003306)2.65779124
33Stenosis of the external auditory canal (HP:0000402)2.65197275
34Trismus (HP:0000211)2.58941349
35Retinal dysplasia (HP:0007973)2.58603925
36Action tremor (HP:0002345)2.52695657
37Vacuolated lymphocytes (HP:0001922)2.50818041
38Buphthalmos (HP:0000557)2.49926957
39Abnormality of the vasculature of the conjunctiva (HP:0008054)2.49103524
40Ulnar claw (HP:0001178)2.46515841
41Apathy (HP:0000741)2.45946037
42Agitation (HP:0000713)2.43016325
43Coronal craniosynostosis (HP:0004440)2.42854760
44Axonal loss (HP:0003447)2.39431785
45Nonimmune hydrops fetalis (HP:0001790)2.36134984
46Arterial tortuosity (HP:0005116)2.36103601
47Diminished motivation (HP:0000745)2.35329654
48Vascular tortuosity (HP:0004948)2.35248623
49Multiple enchondromatosis (HP:0005701)2.33959509
50Amblyopia (HP:0000646)2.32244141
51Focal motor seizures (HP:0011153)2.29387451
52Focal seizures (HP:0007359)2.29133480
53Drooling (HP:0002307)2.26659474
54Excessive salivation (HP:0003781)2.26659474
55Inappropriate behavior (HP:0000719)2.26356605
56Subacute progressive viral hepatitis (HP:0006572)2.23246288
57Hematochezia (HP:0002573)2.22701421
58Conjunctival telangiectasia (HP:0000524)2.21931986
59Hypoplasia of the brainstem (HP:0002365)2.21829926
60Aplasia/Hypoplasia of the brainstem (HP:0007362)2.21829926
61Progressive cerebellar ataxia (HP:0002073)2.19607795
62Neuroendocrine neoplasm (HP:0100634)2.14702673
63Hand muscle atrophy (HP:0009130)2.14179356
64Lissencephaly (HP:0001339)2.14086446
65Morphological abnormality of the pyramidal tract (HP:0002062)2.13981625
66Upper limb amyotrophy (HP:0009129)2.13932667
67Distal upper limb amyotrophy (HP:0007149)2.13932667
68Wormian bones (HP:0002645)2.13803310
69Disinhibition (HP:0000734)2.13747815
70Adactyly (HP:0009776)2.12976232
71Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.12654228
72Genu recurvatum (HP:0002816)2.11300583
73Curly hair (HP:0002212)2.11010836
74Overgrowth (HP:0001548)2.08525700
75Cerebral hemorrhage (HP:0001342)2.08168955
76Loss of speech (HP:0002371)2.07816509
77Spastic diplegia (HP:0001264)2.05409850
78Bronchomalacia (HP:0002780)2.04831285
79Pachygyria (HP:0001302)2.03482375
80Poor head control (HP:0002421)2.03171862
81Aqueductal stenosis (HP:0002410)2.01441332
82Follicular hyperkeratosis (HP:0007502)2.01304862
83Bladder diverticulum (HP:0000015)1.99703331
84Fasciculations (HP:0002380)1.99072089
85Spastic gait (HP:0002064)1.97805244
86Epileptic encephalopathy (HP:0200134)1.96510783
87Exotropia (HP:0000577)1.96454230
88Hyperparathyroidism (HP:0000843)1.95901269
89Split foot (HP:0001839)1.95069837
90Abnormal hemoglobin (HP:0011902)1.94919628
91Rough bone trabeculation (HP:0100670)1.94263618
92Esophageal varix (HP:0002040)1.94128347
93Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.94099572
94Aplasia involving bones of the upper limbs (HP:0009823)1.93613838
95Aplasia of the phalanges of the hand (HP:0009802)1.93613838
96Aplasia involving bones of the extremities (HP:0009825)1.93613838
97Papilledema (HP:0001085)1.93298455
98Lower limb muscle weakness (HP:0007340)1.93192956
99Wrist flexion contracture (HP:0001239)1.91927993
100Hydroureter (HP:0000072)1.90853217
101Ankyloglossia (HP:0010296)1.89480577
102Achilles tendon contracture (HP:0001771)1.89145203
103Hypercortisolism (HP:0001578)1.87610521
104Natal tooth (HP:0000695)1.87269519
105Rapidly progressive (HP:0003678)1.86852846
106Abnormality of the phalanges of the hallux (HP:0010057)1.85846958
107Congenital glaucoma (HP:0001087)1.84255586
108Porencephaly (HP:0002132)1.83421360
109Absence seizures (HP:0002121)1.82981113
110Hyperthyroidism (HP:0000836)1.82888712
111Multiple lipomas (HP:0001012)1.82688877
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.82401854
113Osteolytic defects of the hand bones (HP:0009699)1.82401854
114Neoplasm of the peripheral nervous system (HP:0100007)1.81916101
115Atonic seizures (HP:0010819)1.81666116
116Thickened helices (HP:0000391)1.81507108
117Atrioventricular block (HP:0001678)1.81239419
118Shoulder girdle muscle weakness (HP:0003547)1.80487177
119Back pain (HP:0003418)1.80438788
120Abnormal trabecular bone morphology (HP:0100671)1.80041480
121Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.79905963
122Neoplasm of the adrenal cortex (HP:0100641)1.79317138
123Congenital ichthyosiform erythroderma (HP:0007431)1.79286407
124Abnormality of placental membranes (HP:0011409)1.75444615
125Amniotic constriction ring (HP:0009775)1.75444615
126Thick nail (HP:0001805)1.75173967
127Fragile skin (HP:0001030)1.74797096
128Progressive inability to walk (HP:0002505)1.74696434
129Fibroma (HP:0010614)1.74466606
130Genetic anticipation (HP:0003743)1.74285275
131Dysostosis multiplex (HP:0000943)1.74134839
132Absent speech (HP:0001344)1.74001640
133Shallow orbits (HP:0000586)1.73808308
134Hamartoma of the eye (HP:0010568)1.72630197
135Myocardial infarction (HP:0001658)1.71561844
136Upper motor neuron abnormality (HP:0002127)1.71320184
137Urinary bladder sphincter dysfunction (HP:0002839)1.70660999
138Blue sclerae (HP:0000592)1.69967054
139Abnormality of salivation (HP:0100755)1.69152643
140Concave nail (HP:0001598)1.69146237
141Skull defect (HP:0001362)1.68695544
142Cortical dysplasia (HP:0002539)1.67503134
143Nuclear cataract (HP:0100018)1.66464842
144Hypoplastic left heart (HP:0004383)1.66425351
145Fibrous tissue neoplasm (HP:0012316)1.65760673
146Elbow flexion contracture (HP:0002987)1.65602129
147Broad-based gait (HP:0002136)1.64996809
148Sudden death (HP:0001699)1.64480792
149Conjunctival hamartoma (HP:0100780)1.64195342
150Absent hand (HP:0004050)1.64019600
151Increased cerebral lipofuscin (HP:0011813)1.63581941
152Anxiety (HP:0000739)1.62473622
153Neoplasm of the adrenal gland (HP:0100631)1.61981723
154Polyphagia (HP:0002591)1.61725503
155Stomach cancer (HP:0012126)1.60728912
156Premature loss of primary teeth (HP:0006323)1.60248009
157Abnormal umbilical cord blood vessels (HP:0011403)1.60041510
158Single umbilical artery (HP:0001195)1.60041510
159Abnormality of the fetal cardiovascular system (HP:0010948)1.60041510
160Depression (HP:0000716)1.59660857
161Restlessness (HP:0000711)1.59256899
162Aplasia/Hypoplasia of the clavicles (HP:0006710)1.58840712
163Sparse eyelashes (HP:0000653)1.58576249
164Dry hair (HP:0011359)1.56662212
165Chin dimple (HP:0010751)1.55178364
166Absent eyelashes (HP:0000561)1.55168399
167Abnormality of dentin (HP:0010299)1.54724118
168Sporadic (HP:0003745)1.54359829
169Abnormality of the Achilles tendon (HP:0005109)1.54143911
170Humeroradial synostosis (HP:0003041)1.54124604
171Synostosis involving the elbow (HP:0003938)1.54124604
172Abnormality of the anterior horn cell (HP:0006802)1.53755617
173Degeneration of anterior horn cells (HP:0002398)1.53755617
174Upper limb muscle weakness (HP:0003484)1.53584380
175Aplasia cutis congenita (HP:0001057)1.53480684
176Abnormality of the intrinsic pathway (HP:0010989)1.52848263
177Hammertoe (HP:0001765)1.52438937
178Reduced antithrombin III activity (HP:0001976)1.52156934
179Abnormalities of placenta or umbilical cord (HP:0001194)1.52122591
180Colon cancer (HP:0003003)1.50287589
181Parakeratosis (HP:0001036)1.49939734
182Type II lissencephaly (HP:0007260)1.49719411
183Steppage gait (HP:0003376)1.49412629

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK16.08917184
2TIE14.97106983
3NME23.72474770
4LATS22.95360985
5MAP3K92.91394121
6LIMK12.80129803
7TGFBR22.69841585
8IRAK32.68048919
9DYRK22.41847267
10MINK12.36098857
11PAK62.27405064
12PAK42.18426359
13PHKG22.15161759
14PHKG12.15161759
15PNCK2.14251786
16RIPK12.09943160
17SRPK12.08780752
18KSR12.08528227
19TGFBR12.08043172
20EPHB21.93977250
21MOS1.91207206
22NTRK31.90636726
23PAK31.86351938
24KSR21.80927303
25PTK21.80300159
26KDR1.79405582
27STK391.67133233
28STK241.67086232
29PIM21.62766037
30ERBB31.61357881
31CSNK1G21.61313894
32ICK1.60741818
33NTRK11.53432134
34TESK11.50828941
35MAP3K41.46863613
36CSNK1G31.44775875
37MAPK131.44043044
38EPHA41.43837010
39BCR1.40381286
40NTRK21.36581792
41TYRO31.32631990
42TAOK21.31222771
43TESK21.30521070
44FER1.30322935
45CDC71.28014696
46VRK21.27714381
47CSNK1A1L1.26723875
48TTK1.25271430
49GRK71.24360739
50FGFR21.23818127
51MKNK11.23384293
52BUB11.22761753
53DYRK31.22410857
54LMTK21.20637154
55DDR21.17188131
56RPS6KA41.17138557
57CDK141.17133963
58WNK41.15916670
59UHMK11.13898102
60PLK21.12956759
61TNIK1.10997261
62BRSK21.09590094
63CDK51.09400383
64PKN11.07317794
65NEK11.01053006
66STK160.99539315
67CSNK1G10.97887431
68CASK0.95781062
69FGR0.95028438
70MAP2K70.93040987
71CDK150.92317480
72DAPK20.92271814
73CDK190.92079952
74CDK180.90909432
75WEE10.88188694
76MKNK20.88061580
77ILK0.87572586
78PDGFRA0.85657182
79ROCK20.84228727
80MET0.84000754
81CDK11A0.83598515
82EIF2AK10.82319307
83TRIB30.80767771
84MAP3K20.80279993
85PRKG20.77042457
86BCKDK0.76677280
87MAP2K40.75173755
88DAPK30.74984828
89PBK0.74490188
90OXSR10.74426893
91NEK90.74374283
92FRK0.73633636
93PRKCZ0.73503700
94CAMK2B0.73414312
95RET0.73363550
96EIF2AK30.72374637
97SCYL20.72239429
98NME10.71918153
99WNK30.71851456
100CAMK2A0.71218270
101STK30.70836126
102ACVR1B0.70834720
103ARAF0.69885382
104EPHA20.69562804
105TAF10.69426593
106LATS10.69014138
107DYRK1A0.68858059
108ROCK10.68765436
109BRAF0.66925750
110TSSK60.66767990
111PRKCE0.63548952
112MAP2K10.62200330
113MATK0.61565716
114ABL20.61177377
115WNK10.61157717
116CAMKK10.61135909
117MYLK0.60985120
118MAP3K80.60781666
119PAK20.60313766
120GRK50.59260753
121PLK10.58577067
122CAMK2D0.57767029
123MARK20.55871643
124PLK30.55807637
125MAP3K120.54317951
126MAPKAPK30.53640505
127CLK10.50337313
128CAMK1G0.49531480
129PRKCG0.49273119
130MAP3K140.48438522
131FGFR10.48316419
132STK100.47954894
133FYN0.47930527
134STK110.47927995
135ALK0.46976806
136SIK20.46384393
137CDK60.46250148
138STK380.45374938
139DMPK0.45322356
140DYRK1B0.45087959
141MAP2K20.43442969
142CAMK2G0.43378966
143CSNK1E0.43024176
144CDK90.42896631
145RAF10.42793014
146TLK10.42552099
147PRKCI0.42309907
148PRKD10.40846473
149MAPKAPK50.40375394
150PRPF4B0.39134747
151MAP3K30.38976937
152LRRK20.38179853
153EGFR0.37476246
154STK38L0.37437648
155EPHB10.36474496
156ERBB40.35412439
157MAPK90.35345352
158MAPK70.34250918
159MAP3K130.34122555
160MST1R0.33748813
161MAP3K50.33217871
162PDK20.33011903
163PLK40.32923319

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.20936728
2Protein export_Homo sapiens_hsa030602.94082620
3Axon guidance_Homo sapiens_hsa043602.34672975
4Lysosome_Homo sapiens_hsa041422.19847514
5Ribosome_Homo sapiens_hsa030102.15438697
6Shigellosis_Homo sapiens_hsa051312.02853328
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01939306
8Sulfur metabolism_Homo sapiens_hsa009201.92131820
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90292575
10Synaptic vesicle cycle_Homo sapiens_hsa047211.89012135
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.88583032
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86891252
13Dopaminergic synapse_Homo sapiens_hsa047281.85027063
14Nicotine addiction_Homo sapiens_hsa050331.82342008
15Long-term potentiation_Homo sapiens_hsa047201.79471957
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78142093
17Spliceosome_Homo sapiens_hsa030401.77436836
18Rheumatoid arthritis_Homo sapiens_hsa053231.74335449
19Renal cell carcinoma_Homo sapiens_hsa052111.70474219
20Other glycan degradation_Homo sapiens_hsa005111.70388466
21Gap junction_Homo sapiens_hsa045401.69901379
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64593235
23Circadian entrainment_Homo sapiens_hsa047131.61960536
24Olfactory transduction_Homo sapiens_hsa047401.60022105
25GABAergic synapse_Homo sapiens_hsa047271.57142864
26Glutamatergic synapse_Homo sapiens_hsa047241.56426003
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.55270394
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.54874104
29Cardiac muscle contraction_Homo sapiens_hsa042601.53919506
30Long-term depression_Homo sapiens_hsa047301.53706907
31Dorso-ventral axis formation_Homo sapiens_hsa043201.52165010
32Glioma_Homo sapiens_hsa052141.51843593
33Cholinergic synapse_Homo sapiens_hsa047251.50947145
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48204934
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.47066601
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.46472763
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44610312
38Estrogen signaling pathway_Homo sapiens_hsa049151.43526832
39Endometrial cancer_Homo sapiens_hsa052131.42946368
40ErbB signaling pathway_Homo sapiens_hsa040121.42243451
41Serotonergic synapse_Homo sapiens_hsa047261.41723420
42Amphetamine addiction_Homo sapiens_hsa050311.38965236
43Gastric acid secretion_Homo sapiens_hsa049711.36809039
44Alzheimers disease_Homo sapiens_hsa050101.36522526
45Cocaine addiction_Homo sapiens_hsa050301.36036976
46ECM-receptor interaction_Homo sapiens_hsa045121.35845692
47Parkinsons disease_Homo sapiens_hsa050121.33872864
48GnRH signaling pathway_Homo sapiens_hsa049121.33364897
49Hippo signaling pathway_Homo sapiens_hsa043901.32418097
50Renin secretion_Homo sapiens_hsa049241.32168943
51Oxidative phosphorylation_Homo sapiens_hsa001901.30283032
52RNA transport_Homo sapiens_hsa030131.27400329
53DNA replication_Homo sapiens_hsa030301.27094611
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26869680
55Oxytocin signaling pathway_Homo sapiens_hsa049211.26827251
56Melanogenesis_Homo sapiens_hsa049161.26504304
57Morphine addiction_Homo sapiens_hsa050321.26461844
58Tight junction_Homo sapiens_hsa045301.25865309
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.25011226
60Phagosome_Homo sapiens_hsa041451.22154521
61Salivary secretion_Homo sapiens_hsa049701.22034229
62Colorectal cancer_Homo sapiens_hsa052101.20814407
63p53 signaling pathway_Homo sapiens_hsa041151.19801298
64Cell cycle_Homo sapiens_hsa041101.19687256
65Mismatch repair_Homo sapiens_hsa034301.19682316
66Amoebiasis_Homo sapiens_hsa051461.19661595
67Collecting duct acid secretion_Homo sapiens_hsa049661.17052191
68Hedgehog signaling pathway_Homo sapiens_hsa043401.16109056
69Thyroid cancer_Homo sapiens_hsa052161.15703670
70VEGF signaling pathway_Homo sapiens_hsa043701.12583311
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12145523
72Pertussis_Homo sapiens_hsa051331.09134006
73Galactose metabolism_Homo sapiens_hsa000521.08908422
74Fatty acid elongation_Homo sapiens_hsa000621.08757737
75Glutathione metabolism_Homo sapiens_hsa004801.08273061
76Nucleotide excision repair_Homo sapiens_hsa034201.06712964
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05842645
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04896534
79Folate biosynthesis_Homo sapiens_hsa007901.04230502
80Sphingolipid signaling pathway_Homo sapiens_hsa040711.02454989
81Base excision repair_Homo sapiens_hsa034101.02316168
82Insulin secretion_Homo sapiens_hsa049111.01117376
83Malaria_Homo sapiens_hsa051441.00475668
84AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99248370
85Vibrio cholerae infection_Homo sapiens_hsa051100.98473543
86Basal cell carcinoma_Homo sapiens_hsa052170.97676454
87Dilated cardiomyopathy_Homo sapiens_hsa054140.97119077
88Wnt signaling pathway_Homo sapiens_hsa043100.96973271
89* Ras signaling pathway_Homo sapiens_hsa040140.96706237
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.96278844
91Huntingtons disease_Homo sapiens_hsa050160.95835315
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.95238866
93Legionellosis_Homo sapiens_hsa051340.94879435
94Endocytosis_Homo sapiens_hsa041440.94879305
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94627350
96Steroid biosynthesis_Homo sapiens_hsa001000.93947458
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93508104
98Taste transduction_Homo sapiens_hsa047420.92913554
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.90742462
100N-Glycan biosynthesis_Homo sapiens_hsa005100.90399280
101Oocyte meiosis_Homo sapiens_hsa041140.89972534
102Viral myocarditis_Homo sapiens_hsa054160.89942795
103Choline metabolism in cancer_Homo sapiens_hsa052310.85023022
104Basal transcription factors_Homo sapiens_hsa030220.84904004
105cAMP signaling pathway_Homo sapiens_hsa040240.84548741
106* Rap1 signaling pathway_Homo sapiens_hsa040150.83526102
107Sphingolipid metabolism_Homo sapiens_hsa006000.82956203
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.81839318
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.81836550
110Alcoholism_Homo sapiens_hsa050340.81308145
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.80743945
112RNA polymerase_Homo sapiens_hsa030200.80489597
113Small cell lung cancer_Homo sapiens_hsa052220.80260320
114Melanoma_Homo sapiens_hsa052180.79870409
115* Phospholipase D signaling pathway_Homo sapiens_hsa040720.79775972
116Pyrimidine metabolism_Homo sapiens_hsa002400.79392272
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77904677
118TNF signaling pathway_Homo sapiens_hsa046680.75851489
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75769649
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75511250
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74044196
122Proteoglycans in cancer_Homo sapiens_hsa052050.72686333
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72270730
124Bladder cancer_Homo sapiens_hsa052190.72202866
125mRNA surveillance pathway_Homo sapiens_hsa030150.71572062
126Focal adhesion_Homo sapiens_hsa045100.71561394
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.70944296
128Adherens junction_Homo sapiens_hsa045200.70934700
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70656822
130Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69421280
131* Pathways in cancer_Homo sapiens_hsa052000.66495950
132MAPK signaling pathway_Homo sapiens_hsa040100.65672779
133Prion diseases_Homo sapiens_hsa050200.64797357
134Insulin signaling pathway_Homo sapiens_hsa049100.64612084
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63800052
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63724182
137Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63301070
138Selenocompound metabolism_Homo sapiens_hsa004500.63143012
139Pancreatic secretion_Homo sapiens_hsa049720.62825338
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62030538
141Leukocyte transendothelial migration_Homo sapiens_hsa046700.61202532
142Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61038897
143Calcium signaling pathway_Homo sapiens_hsa040200.60420834
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58115754
145Salmonella infection_Homo sapiens_hsa051320.57786697
146MicroRNAs in cancer_Homo sapiens_hsa052060.57748147
147Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55494433
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54859855
149Type II diabetes mellitus_Homo sapiens_hsa049300.53609862
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51390676
151Sulfur relay system_Homo sapiens_hsa041220.51354803
152Non-small cell lung cancer_Homo sapiens_hsa052230.50815010
153Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50431709
154Chronic myeloid leukemia_Homo sapiens_hsa052200.49352345
155RNA degradation_Homo sapiens_hsa030180.49316372
156Prolactin signaling pathway_Homo sapiens_hsa049170.49205753
157TGF-beta signaling pathway_Homo sapiens_hsa043500.48944004
158Renin-angiotensin system_Homo sapiens_hsa046140.48469043
159Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48379105
160Biosynthesis of amino acids_Homo sapiens_hsa012300.46887004
161Apoptosis_Homo sapiens_hsa042100.46220655
162HIF-1 signaling pathway_Homo sapiens_hsa040660.46188066
163Epstein-Barr virus infection_Homo sapiens_hsa051690.45377097
164Pentose phosphate pathway_Homo sapiens_hsa000300.45261122
165Central carbon metabolism in cancer_Homo sapiens_hsa052300.44257345
166Mineral absorption_Homo sapiens_hsa049780.43938346

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