RAF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.97043673
2negative regulation of cell killing (GO:0031342)5.97043673
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.22174261
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.22174261
5modulation by symbiont of host immune response (GO:0052553)5.22174261
6positive regulation by symbiont of host defense response (GO:0052509)5.22174261
7modulation by symbiont of host defense response (GO:0052031)5.22174261
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.22174261
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.01941219
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.81635498
11detection of molecule of bacterial origin (GO:0032490)4.47846992
12antigen processing and presentation of endogenous antigen (GO:0019883)4.40008196
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29731062
14detection of other organism (GO:0098543)4.22979593
15response to peptidoglycan (GO:0032494)4.09966270
16positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.07911153
17response to interleukin-15 (GO:0070672)4.06811500
18macrophage activation involved in immune response (GO:0002281)4.02101070
19low-density lipoprotein particle clearance (GO:0034383)4.01167474
20negative regulation of lymphocyte mediated immunity (GO:0002707)4.00959937
21cellular extravasation (GO:0045123)3.99921059
22detection of external biotic stimulus (GO:0098581)3.93236071
23regulation of B cell receptor signaling pathway (GO:0050855)3.83887002
24detection of bacterium (GO:0016045)3.83311586
25neutrophil mediated immunity (GO:0002446)3.79665839
26fatty acid transmembrane transport (GO:1902001)3.72244571
27negative regulation of erythrocyte differentiation (GO:0045647)3.67729546
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.65278243
29response to host immune response (GO:0052572)3.65278243
30carnitine shuttle (GO:0006853)3.63865524
31regulation of interferon-beta biosynthetic process (GO:0045357)3.61473295
32regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57414399
33leukocyte aggregation (GO:0070486)3.57166905
34cellular response to interleukin-15 (GO:0071350)3.55908583
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.54580820
36response to muramyl dipeptide (GO:0032495)3.54036676
37alpha-linolenic acid metabolic process (GO:0036109)3.52634034
38detection of biotic stimulus (GO:0009595)3.47491099
39response to host (GO:0075136)3.42833492
40response to host defenses (GO:0052200)3.42833492
41response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.42833492
42germinal center formation (GO:0002467)3.41997289
43leukocyte migration involved in inflammatory response (GO:0002523)3.40143813
44lysine metabolic process (GO:0006553)3.37823535
45lysine catabolic process (GO:0006554)3.37823535
46urea cycle (GO:0000050)3.35454851
47urea metabolic process (GO:0019627)3.35454851
48respiratory burst (GO:0045730)3.33451066
49negative regulation of leukocyte mediated immunity (GO:0002704)3.30511157
50regulation of necroptotic process (GO:0060544)3.28122498
51positive regulation of fatty acid beta-oxidation (GO:0032000)3.25878739
52dosage compensation (GO:0007549)3.24900538
53neutrophil activation involved in immune response (GO:0002283)3.24579874
54mitotic chromosome condensation (GO:0007076)3.23333059
552-oxoglutarate metabolic process (GO:0006103)3.19012739
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.17534358
57neutrophil activation (GO:0042119)3.17084920
58regulation of hippo signaling (GO:0035330)3.14949846
59negative regulation of T cell mediated immunity (GO:0002710)3.13992044
60B cell receptor signaling pathway (GO:0050853)3.12924441
61regulation of sequestering of triglyceride (GO:0010889)3.12912767
62regulation of fatty acid beta-oxidation (GO:0031998)3.12601276
63negative regulation of interleukin-12 production (GO:0032695)3.11609767
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10684016
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08742515
66negative regulation of T-helper cell differentiation (GO:0045623)3.08742515
67plasma lipoprotein particle clearance (GO:0034381)3.07207608
68myeloid leukocyte mediated immunity (GO:0002444)3.02870102
69cytoplasmic mRNA processing body assembly (GO:0033962)3.02721658
70valine metabolic process (GO:0006573)2.98919488
71triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.97475250
72negative regulation of fatty acid biosynthetic process (GO:0045717)2.96509086
73ethanol oxidation (GO:0006069)2.92912785
74positive regulation of lipid storage (GO:0010884)2.92394021
75phospholipid homeostasis (GO:0055091)2.91783473
76macrophage activation (GO:0042116)2.91125663
77intracellular estrogen receptor signaling pathway (GO:0030520)2.90606396
78regulation of cholesterol storage (GO:0010885)2.90250246
79negative regulation of cell size (GO:0045792)2.88758406
80paraxial mesoderm development (GO:0048339)2.87632691
81cardiac myofibril assembly (GO:0055003)2.87320201
82fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.86020734
83negative regulation of necroptotic process (GO:0060546)2.85483542
84antigen processing and presentation via MHC class Ib (GO:0002475)2.85256884
85regulation of natural killer cell mediated immunity (GO:0002715)2.84079952
86regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84079952
87nitrogen cycle metabolic process (GO:0071941)2.82715735
88regulation of cholesterol homeostasis (GO:2000188)2.81427352
89negative thymic T cell selection (GO:0045060)2.81004697
90negative regulation of immunoglobulin mediated immune response (GO:0002890)2.79164627
91negative regulation of B cell mediated immunity (GO:0002713)2.79164627
92microglial cell activation (GO:0001774)2.78942642
93granulocyte activation (GO:0036230)2.78775759
94positive T cell selection (GO:0043368)2.78425392
95positive regulation of natural killer cell differentiation (GO:0032825)2.78394893
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.77900572
97cellular ketone body metabolic process (GO:0046950)2.77074275
98complement activation, alternative pathway (GO:0006957)2.76705703
99fibroblast migration (GO:0010761)2.75254267
100positive regulation of fatty acid oxidation (GO:0046321)2.74624438
101production of molecular mediator involved in inflammatory response (GO:0002532)2.73758325
102histone H2A monoubiquitination (GO:0035518)2.73448535
103embryonic process involved in female pregnancy (GO:0060136)2.73395461
104cysteine metabolic process (GO:0006534)2.70647770
105negative T cell selection (GO:0043383)2.70009004
106negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.69569329
107negative regulation of fibrinolysis (GO:0051918)2.69167138
108negative regulation of myotube differentiation (GO:0010832)2.68616292
109regulation of T-helper 2 cell differentiation (GO:0045628)2.68225669
110regulation of protein activation cascade (GO:2000257)2.65463259
111pentose-phosphate shunt (GO:0006098)2.63055909
112histone H3-K36 demethylation (GO:0070544)2.62894063
113skeletal muscle adaptation (GO:0043501)2.62484243
114sarcomere organization (GO:0045214)2.61994710
115positive thymic T cell selection (GO:0045059)2.61934898
116glyoxylate metabolic process (GO:0046487)2.60345905
117pre-miRNA processing (GO:0031054)2.59571802
118positive regulation of interleukin-17 production (GO:0032740)2.59187524
119regulation of fatty acid oxidation (GO:0046320)2.58801954
120negative regulation of toll-like receptor signaling pathway (GO:0034122)2.57333669
121kynurenine metabolic process (GO:0070189)2.57270405
122amino-acid betaine metabolic process (GO:0006577)2.57249118
123negative regulation of adaptive immune response (GO:0002820)2.57128436
124carnitine transmembrane transport (GO:1902603)2.56759334
125serine family amino acid catabolic process (GO:0009071)2.55915674
126negative regulation of histone methylation (GO:0031061)2.55639458
127T cell selection (GO:0045058)2.54255870
128negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.54155400
129positive regulation of lipid catabolic process (GO:0050996)2.54088156
130regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54004980
131negative regulation of fatty acid metabolic process (GO:0045922)2.53266658
132acetyl-CoA metabolic process (GO:0006084)2.53161588
133natural killer cell differentiation (GO:0001779)2.53145623
134regulation of NFAT protein import into nucleus (GO:0051532)2.52789894
135regulation of complement activation (GO:0030449)2.52215018
136growth hormone receptor signaling pathway (GO:0060396)2.52085124
137regulation of interleukin-12 biosynthetic process (GO:0045075)2.51960549
138tricarboxylic acid metabolic process (GO:0072350)2.51254129
139dicarboxylic acid biosynthetic process (GO:0043650)2.51237062
140fatty acid homeostasis (GO:0055089)2.50411397
141JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.50016659
142epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49634942
143L-phenylalanine metabolic process (GO:0006558)2.49154463
144erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.49154463
145positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48716722
146histone lysine demethylation (GO:0070076)2.48383736
147regulation of sister chromatid cohesion (GO:0007063)2.48297220
148negative regulation of alpha-beta T cell activation (GO:0046636)2.47408431
149positive regulation of histone deacetylation (GO:0031065)2.45667451
150cardiac muscle cell development (GO:0055013)2.45280165
151ketone body metabolic process (GO:1902224)2.45243023
152glycine metabolic process (GO:0006544)2.45179092
153NADPH regeneration (GO:0006740)2.45069377
154positive regulation of gamma-delta T cell activation (GO:0046645)2.45027671
155cellular response to type I interferon (GO:0071357)2.44942213
156type I interferon signaling pathway (GO:0060337)2.44942213
157creatine metabolic process (GO:0006600)2.44592131
158defense response to protozoan (GO:0042832)2.43896820
159positive regulation of SMAD protein import into nucleus (GO:0060391)2.43500698
160regulation of triglyceride catabolic process (GO:0010896)2.43425145
161erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43226743
162L-phenylalanine catabolic process (GO:0006559)2.43226743
163regulation of mast cell degranulation (GO:0043304)2.43003722
164regulation of B cell differentiation (GO:0045577)2.42998901
165response to type I interferon (GO:0034340)2.42975523
166RNA stabilization (GO:0043489)2.42912697
167mRNA stabilization (GO:0048255)2.42912697
168negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.42503045
169peptidyl-glutamic acid carboxylation (GO:0017187)2.42082089
170protein carboxylation (GO:0018214)2.42082089
171negative regulation of interleukin-6 production (GO:0032715)2.41680298
172carnitine transport (GO:0015879)2.41620910
173amino-acid betaine transport (GO:0015838)2.41620910
174histone H4 deacetylation (GO:0070933)2.41452087
175striated muscle atrophy (GO:0014891)2.39900069
176positive regulation of glycogen biosynthetic process (GO:0045725)2.39414625
177folic acid-containing compound biosynthetic process (GO:0009396)2.37779450
178myofibril assembly (GO:0030239)2.36457947
179carnitine metabolic process (GO:0009437)2.36029805
180one-carbon metabolic process (GO:0006730)2.35268406
181ethanol metabolic process (GO:0006067)2.35144261
182histone demethylation (GO:0016577)2.35034997
183sulfur amino acid catabolic process (GO:0000098)2.34081143
184negative regulation of cholesterol transport (GO:0032375)2.33451778
185negative regulation of sterol transport (GO:0032372)2.33451778
186cardiac cell development (GO:0055006)2.33378008
1873-UTR-mediated mRNA stabilization (GO:0070935)2.33069281
188DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.32600074
189regulation of SMAD protein import into nucleus (GO:0060390)2.32541119
190fatty acid beta-oxidation (GO:0006635)2.32493865
191regulation of gamma-delta T cell activation (GO:0046643)2.32491841
192regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.30587293
193regulation of gamma-delta T cell differentiation (GO:0045586)2.29008880
194protein demethylation (GO:0006482)2.27375838
195protein dealkylation (GO:0008214)2.27375838

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.63233370
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.55523034
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.03092274
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.66516225
5E2F7_22180533_ChIP-Seq_HELA_Human3.40991010
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34242909
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.31811278
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.21273774
9PPARA_22158963_ChIP-Seq_LIVER_Mouse3.19485011
10MYC_22102868_ChIP-Seq_BL_Human2.79092217
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.67675216
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.67487173
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.66813091
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.60970764
15CLOCK_20551151_ChIP-Seq_293T_Human2.54451236
16FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54403594
17RUNX_20019798_ChIP-Seq_JUKART_Human2.23379080
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.22677605
19SPI1_23127762_ChIP-Seq_K562_Human2.21535836
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20011264
21SPI1_23547873_ChIP-Seq_NB4_Human2.18101993
22* RUNX1_22412390_ChIP-Seq_EML_Mouse2.14916346
23IRF8_27001747_Chip-Seq_BMDM_Mouse2.13635852
24MYB_26560356_Chip-Seq_TH2_Human2.12748204
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03699197
26MAF_26560356_Chip-Seq_TH2_Human2.02819206
27VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02605109
28* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01150931
29TCF7_22412390_ChIP-Seq_EML_Mouse1.97850888
30ZNF263_19887448_ChIP-Seq_K562_Human1.91587244
31KDM2B_26808549_Chip-Seq_DND41_Human1.90580775
32SCL_19346495_ChIP-Seq_HPC-7_Human1.89416895
33MYB_26560356_Chip-Seq_TH1_Human1.88801015
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.85387308
35CIITA_25753668_ChIP-Seq_RAJI_Human1.83765371
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.83761625
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80617222
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78851319
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78470623
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78103099
41KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76610537
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.76574686
43GATA1_22025678_ChIP-Seq_K562_Human1.76006966
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.73387276
45VDR_21846776_ChIP-Seq_THP-1_Human1.71119273
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.70744705
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68976466
48AR_21909140_ChIP-Seq_LNCAP_Human1.66038697
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64487429
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.60571587
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.58273257
52ATF3_27146783_Chip-Seq_COLON_Human1.55269686
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52550218
54UTX_26944678_Chip-Seq_JUKART_Human1.51508276
55CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51185825
56MAF_26560356_Chip-Seq_TH1_Human1.48814996
57* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48786249
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47956937
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46992122
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46493718
61EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45930211
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.44093754
63RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43278498
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.40403196
65VDR_24787735_ChIP-Seq_THP-1_Human1.40289655
66GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39553660
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.38777904
68* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.38741919
69BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37600095
70TP63_17297297_ChIP-ChIP_HaCaT_Human1.35170237
71HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34201054
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32962442
73KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32736067
74GATA3_27048872_Chip-Seq_THYMUS_Human1.31637498
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.30409870
76KDM2B_26808549_Chip-Seq_JURKAT_Human1.29948872
77SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29544122
78RACK7_27058665_Chip-Seq_MCF-7_Human1.29369010
79IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27120974
80CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27083359
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26497081
82PU_27001747_Chip-Seq_BMDM_Mouse1.25306335
83ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24039277
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.23331632
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22850202
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.22371338
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22084961
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20696191
89FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.19384202
90TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19144401
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19124220
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.18705639
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.18705639
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18355447
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15890620
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15263117
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14993864
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14692946
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14666763
100E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14637871
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14519192
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13945738
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13507702
104DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12446718
105ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.12440014
106CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09980442
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09378359
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08778909
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08636646
110NCOR1_26117541_ChIP-Seq_K562_Human1.08276452
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07969548
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06818959
113CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06662895
114* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06657250
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06344130
116* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06073357
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05988456
118GATA1_19941826_ChIP-Seq_K562_Human1.05282439
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.05191319
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04432958
121* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04148871
122* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04097339
123FOXA2_19822575_ChIP-Seq_HepG2_Human1.03798221
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03356704
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03269914
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03113896
127TFEB_21752829_ChIP-Seq_HELA_Human1.02570873
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02508853
129CREB1_26743006_Chip-Seq_LNCaP_Human1.02460673
130KDM2B_26808549_Chip-Seq_K562_Human1.02443718
131EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02183363
132NANOG_21062744_ChIP-ChIP_HESCs_Human1.01658777
133PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01616039
134LXR_22292898_ChIP-Seq_THP-1_Human1.01049761
135SALL1_21062744_ChIP-ChIP_HESCs_Human1.01039939
136ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00913040
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00912908
138SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99911390
139E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99265242
140GATA6_25053715_ChIP-Seq_YYC3_Human0.97748466
141RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97635871
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96121974
143SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95904637
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95687333
145* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95644353
146SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95398205
147FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95276646
148CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93465788
149STAT6_21828071_ChIP-Seq_BEAS2B_Human0.93360027
150* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92201072
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.91971166
152* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.91287738
153UBF1/2_26484160_Chip-Seq_HMECs_Human0.91160500
154UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90877914
155VDR_24763502_ChIP-Seq_THP-1_Human0.90322716

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.20205475
2MP0003705_abnormal_hypodermis_morpholog3.56578510
3MP0008260_abnormal_autophagy3.20389483
4MP0002139_abnormal_hepatobiliary_system2.91726375
5MP0005360_urolithiasis2.74533112
6MP0003646_muscle_fatigue2.72769097
7MP0001835_abnormal_antigen_presentation2.57722251
8MP0004185_abnormal_adipocyte_glucose2.51625910
9MP0009840_abnormal_foam_cell2.50842566
10MP0009278_abnormal_bone_marrow2.45633255
11MP0002419_abnormal_innate_immunity2.28808840
12MP0005365_abnormal_bile_salt2.27799199
13MP0004130_abnormal_muscle_cell2.24153796
14MP0003763_abnormal_thymus_physiology2.21023220
15MP0001800_abnormal_humoral_immune2.13778730
16MP0000685_abnormal_immune_system2.02583945
17MP0005025_abnormal_response_to1.98906392
18MP0005666_abnormal_adipose_tissue1.98708328
19MP0005076_abnormal_cell_differentiation1.98574635
20MP0003303_peritoneal_inflammation1.98087788
21MP0002837_dystrophic_cardiac_calcinosis1.92949551
22MP0005000_abnormal_immune_tolerance1.92624087
23MP0000569_abnormal_digit_pigmentation1.92232760
24MP0002723_abnormal_immune_serum1.86050520
25MP0002420_abnormal_adaptive_immunity1.84078831
26MP0002396_abnormal_hematopoietic_system1.80182920
27MP0001819_abnormal_immune_cell1.80171468
28MP0005451_abnormal_body_composition1.79578227
29MP0002009_preneoplasia1.79483745
30MP0001790_abnormal_immune_system1.77666633
31MP0005387_immune_system_phenotype1.77666633
32MP0010352_gastrointestinal_tract_polyps1.75725505
33MP0005085_abnormal_gallbladder_physiolo1.74342638
34MP0002452_abnormal_antigen_presenting1.69700277
35MP0004510_myositis1.68984633
36MP0004087_abnormal_muscle_fiber1.67367223
37MP0002398_abnormal_bone_marrow1.64935231
38MP0000733_abnormal_muscle_development1.64710907
39MP0000703_abnormal_thymus_morphology1.54883485
40MP0010329_abnormal_lipoprotein_level1.53141458
41MP0004084_abnormal_cardiac_muscle1.53007368
42MP0000465_gastrointestinal_hemorrhage1.52889440
43MP0002405_respiratory_system_inflammati1.52413345
44MP0003806_abnormal_nucleotide_metabolis1.51645009
45MP0004381_abnormal_hair_follicle1.50976033
46MP0009785_altered_susceptibility_to1.50940672
47MP0003252_abnormal_bile_duct1.50658542
48MP0001533_abnormal_skeleton_physiology1.50188474
49MP0010630_abnormal_cardiac_muscle1.48170972
50MP0000716_abnormal_immune_system1.47739558
51MP0000749_muscle_degeneration1.46054781
52* MP0000609_abnormal_liver_physiology1.44551262
53MP0003656_abnormal_erythrocyte_physiolo1.43212933
54MP0002653_abnormal_ependyma_morphology1.42756406
55MP0010234_abnormal_vibrissa_follicle1.40813466
56MP0005671_abnormal_response_to1.40068575
57MP0002722_abnormal_immune_system1.39532700
58MP0003566_abnormal_cell_adhesion1.38049601
59MP0003183_abnormal_peptide_metabolism1.36847206
60MP0000750_abnormal_muscle_regeneration1.35322889
61MP0002132_abnormal_respiratory_system1.34126717
62MP0000751_myopathy1.31693255
63MP0000689_abnormal_spleen_morphology1.31547807
64MP0002269_muscular_atrophy1.29853742
65MP0003828_pulmonary_edema1.27030078
66MP0005083_abnormal_biliary_tract1.26204859
67MP0001849_ear_inflammation1.25584020
68MP0005248_abnormal_Harderian_gland1.23069516
69MP0004808_abnormal_hematopoietic_stem1.22193819
70MP0004484_altered_response_of1.21202759
71* MP0003221_abnormal_cardiomyocyte_apopto1.20171451
72MP0002429_abnormal_blood_cell1.19951901
73MP0005330_cardiomyopathy1.19502822
74MP0003172_abnormal_lysosome_physiology1.19395520
75MP0004883_abnormal_blood_vessel1.15973586
76* MP0001730_embryonic_growth_arrest1.15122400
77MP0005023_abnormal_wound_healing1.15065264
78MP0003300_gastrointestinal_ulcer1.14993470
79MP0008961_abnormal_basal_metabolism1.13967930
80MP0005375_adipose_tissue_phenotype1.13746396
81MP0006082_CNS_inflammation1.13552433
82MP0000858_altered_metastatic_potential1.12589983
83MP0010155_abnormal_intestine_physiology1.12155193
84MP0002106_abnormal_muscle_physiology1.11173309
85MP0005670_abnormal_white_adipose1.10771688
86MP0003436_decreased_susceptibility_to1.10590611
87MP0004036_abnormal_muscle_relaxation1.07781144
88MP0001845_abnormal_inflammatory_respons1.07383484
89MP0009672_abnormal_birth_weight1.06900799
90MP0002127_abnormal_cardiovascular_syste1.06068981
91MP0003567_abnormal_fetal_cardiomyocyte1.04646202
92MP0000747_muscle_weakness1.03336178
93MP0004858_abnormal_nervous_system1.03280321
94MP0003191_abnormal_cellular_cholesterol1.02869372
95MP0003077_abnormal_cell_cycle1.02693950
96MP0001851_eye_inflammation1.02179045
97MP0002971_abnormal_brown_adipose1.01804804
98MP0003693_abnormal_embryo_hatching1.01533337
99MP0000767_abnormal_smooth_muscle1.00645168
100MP0000759_abnormal_skeletal_muscle0.99560605
101MP0005464_abnormal_platelet_physiology0.99169183
102* MP0002088_abnormal_embryonic_growth/wei0.97074984
103* MP0001672_abnormal_embryogenesis/_devel0.96547784
104* MP0005380_embryogenesis_phenotype0.96547784
105MP0001915_intracranial_hemorrhage0.96020678
106* MP0004197_abnormal_fetal_growth/weight/0.95877990
107MP0001544_abnormal_cardiovascular_syste0.95675583
108MP0005385_cardiovascular_system_phenoty0.95675583
109MP0002254_reproductive_system_inflammat0.95429505
110MP0001873_stomach_inflammation0.95078624
111* MP0003984_embryonic_growth_retardation0.94686032
112MP0003111_abnormal_nucleus_morphology0.94250749
113MP0010307_abnormal_tumor_latency0.94239661
114MP0005369_muscle_phenotype0.94034472
115MP0002166_altered_tumor_susceptibility0.92190580
116MP0004215_abnormal_myocardial_fiber0.90929610
117* MP0002086_abnormal_extraembryonic_tissu0.90509904
118MP0004145_abnormal_muscle_electrophysio0.89645965
119MP0008057_abnormal_DNA_replication0.89531104
120MP0009333_abnormal_splenocyte_physiolog0.89443534
121MP0003866_abnormal_defecation0.89269226
122MP0005187_abnormal_penis_morphology0.89056883
123MP0004233_abnormal_muscle_weight0.87944244
124MP0002277_abnormal_respiratory_mucosa0.87568817
125MP0008469_abnormal_protein_level0.86785734
126MP0003453_abnormal_keratinocyte_physiol0.86410611
127MP0009384_cardiac_valve_regurgitation0.86265585
128MP0000537_abnormal_urethra_morphology0.85644347
129* MP0000598_abnormal_liver_morphology0.85420727
130MP0002084_abnormal_developmental_patter0.85205855
131* MP0000266_abnormal_heart_morphology0.85032674
132MP0002998_abnormal_bone_remodeling0.84705906
133MP0009053_abnormal_anal_canal0.83918577
134* MP0001697_abnormal_embryo_size0.83233860
135MP0005319_abnormal_enzyme/_coenzyme0.83053378
136* MP0002085_abnormal_embryonic_tissue0.82499185
137MP0004947_skin_inflammation0.82430073
138MP0008875_abnormal_xenobiotic_pharmacok0.82183415
139* MP0002925_abnormal_cardiovascular_devel0.81494361
140MP0002118_abnormal_lipid_homeostasis0.80858630
141MP0008775_abnormal_heart_ventricle0.80747917
142* MP0000350_abnormal_cell_proliferation0.80437005
143MP0005310_abnormal_salivary_gland0.79867985
144MP0005408_hypopigmentation0.79582757
145MP0003091_abnormal_cell_migration0.78732295
146MP0003115_abnormal_respiratory_system0.76743652
147MP0002332_abnormal_exercise_endurance0.76298028
148MP0009764_decreased_sensitivity_to0.76198707
149MP0003045_fibrosis0.75358650
150* MP0005620_abnormal_muscle_contractility0.74458697
151MP0005397_hematopoietic_system_phenotyp0.74387523
152MP0001545_abnormal_hematopoietic_system0.74387523
153* MP0002972_abnormal_cardiac_muscle0.73373807
154* MP0002128_abnormal_blood_circulation0.72512417
155* MP0002080_prenatal_lethality0.72300923
156MP0002148_abnormal_hypersensitivity_rea0.72294160
157MP0001958_emphysema0.72167778
158MP0000428_abnormal_craniofacial_morphol0.71795014
159MP0006138_congestive_heart_failure0.70547064
160* MP0001614_abnormal_blood_vessel0.70444457

Predicted human phenotypes

RankGene SetZ-score
1Myositis (HP:0100614)4.15906854
2Orchitis (HP:0100796)3.93157606
3Deep venous thrombosis (HP:0002625)3.68714725
4Optic neuritis (HP:0100653)3.64467665
5Retrobulbar optic neuritis (HP:0100654)3.64467665
6Gastrointestinal infarctions (HP:0005244)3.55420545
7Recurrent fungal infections (HP:0002841)3.17245478
8Abnormality of macrophages (HP:0004311)3.07802418
9Gingivitis (HP:0000230)3.06054391
10Chest pain (HP:0100749)3.00872442
11Centrally nucleated skeletal muscle fibers (HP:0003687)3.00820328
12Mediastinal lymphadenopathy (HP:0100721)2.99737449
13Cortical dysplasia (HP:0002539)2.97218111
14Stomatitis (HP:0010280)2.96356835
15Increased IgE level (HP:0003212)2.95205076
16Exercise-induced muscle cramps (HP:0003710)2.92899031
17Keratoconjunctivitis sicca (HP:0001097)2.85867617
18Recurrent cutaneous fungal infections (HP:0011370)2.83282894
19Chronic mucocutaneous candidiasis (HP:0002728)2.83282894
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.82671070
21Exercise-induced myalgia (HP:0003738)2.81745285
22Hypoalphalipoproteinemia (HP:0003233)2.75472356
23Xanthomatosis (HP:0000991)2.73420799
24Elevated erythrocyte sedimentation rate (HP:0003565)2.72433248
25Difficulty running (HP:0009046)2.71301048
26Recurrent skin infections (HP:0001581)2.70530716
27Type 1 muscle fiber predominance (HP:0003803)2.70082200
28Abnormality of skeletal muscle fiber size (HP:0012084)2.70042864
29EMG: myopathic abnormalities (HP:0003458)2.68815935
30Spontaneous hematomas (HP:0007420)2.67933704
31Cellulitis (HP:0100658)2.65211579
32Ventricular tachycardia (HP:0004756)2.64895828
33Meningitis (HP:0001287)2.62279127
34Right ventricular cardiomyopathy (HP:0011663)2.61046740
35Increased connective tissue (HP:0009025)2.59583352
36Obstructive lung disease (HP:0006536)2.58769990
37Chronic obstructive pulmonary disease (HP:0006510)2.58769990
38Increased variability in muscle fiber diameter (HP:0003557)2.56566094
39Hypochromic microcytic anemia (HP:0004840)2.51387272
40Keratoconjunctivitis (HP:0001096)2.51083340
41Inflammation of the large intestine (HP:0002037)2.50671961
42Muscle fiber splitting (HP:0003555)2.50469487
43Encephalitis (HP:0002383)2.50359660
44Gastrointestinal inflammation (HP:0004386)2.49406397
45Recurrent gram-negative bacterial infections (HP:0005420)2.49330307
46Abnormality of the 4th metacarpal (HP:0010012)2.48251010
47Hyporeflexia of lower limbs (HP:0002600)2.48127037
48Metaphyseal cupping (HP:0003021)2.48057321
49Lymphangioma (HP:0100764)2.44740867
50Distal lower limb amyotrophy (HP:0008944)2.44291657
51Urticaria (HP:0001025)2.40809386
52Abnormality of the fingertips (HP:0001211)2.39553150
53Intrahepatic cholestasis (HP:0001406)2.37866610
54Pseudobulbar signs (HP:0002200)2.37146823
55Fatigue (HP:0012378)2.36361163
56Short 4th metacarpal (HP:0010044)2.35934278
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.35934278
58* Abnormality of the endocardium (HP:0004306)2.35148682
59Rhabdomyolysis (HP:0003201)2.34793610
60Myoglobinuria (HP:0002913)2.33795172
61Complement deficiency (HP:0004431)2.33637590
62Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.32945223
63Muscle fiber inclusion bodies (HP:0100299)2.32569354
64Myocardial infarction (HP:0001658)2.29784365
65Hyperammonemia (HP:0001987)2.28152600
66Arterial thrombosis (HP:0004420)2.27946408
67Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27127763
68Esophageal varix (HP:0002040)2.26883580
69T lymphocytopenia (HP:0005403)2.26154322
70Epidermoid cyst (HP:0200040)2.24690973
71Ankle contracture (HP:0006466)2.21436089
72Ketosis (HP:0001946)2.20326928
73Cerebral aneurysm (HP:0004944)2.18443698
74Hypochromic anemia (HP:0001931)2.17507529
75Hyperlipoproteinemia (HP:0010980)2.14201371
76Spastic diplegia (HP:0001264)2.13654783
77Sudden death (HP:0001699)2.13100286
78Long toe (HP:0010511)2.11705796
79Asymmetric septal hypertrophy (HP:0001670)2.09180022
80Hypolipoproteinemia (HP:0010981)2.09013044
81Abnormality of monocarboxylic acid metabolism (HP:0010996)2.07663763
82Subaortic stenosis (HP:0001682)2.07641143
83Abnormality of the left ventricular outflow tract (HP:0011103)2.07641143
84Hyperglycinuria (HP:0003108)2.06797108
85Atrioventricular block (HP:0001678)2.06470116
86Aortic aneurysm (HP:0004942)2.04270301
87Subacute progressive viral hepatitis (HP:0006572)2.03537251
88Skin nodule (HP:0200036)2.02982846
89Abnormality of the peritoneum (HP:0002585)2.02829033
90Heterotopia (HP:0002282)2.02692713
91Abnormality of complement system (HP:0005339)2.01857376
92Broad metatarsal (HP:0001783)2.01397936
93Nemaline bodies (HP:0003798)2.00956271
94Hemoptysis (HP:0002105)2.00596465
95Slow saccadic eye movements (HP:0000514)1.99009063
96Shallow orbits (HP:0000586)1.97944975
97Ependymoma (HP:0002888)1.97740673
98Ulnar deviation of the wrist (HP:0003049)1.97702667
99Recurrent viral infections (HP:0004429)1.96889302
100Abnormality of T cell number (HP:0011839)1.95819463
101Vasculitis (HP:0002633)1.95702576
102Hypoglycemic coma (HP:0001325)1.95317801
103Ketoacidosis (HP:0001993)1.95224012
104Pelvic girdle muscle weakness (HP:0003749)1.93453754
105Granulocytopenia (HP:0001913)1.93221113
106Leukocytosis (HP:0001974)1.92820956
107Distal lower limb muscle weakness (HP:0009053)1.91926130
108Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.91708326
109Recurrent bacterial skin infections (HP:0005406)1.90122240
110Mitral valve prolapse (HP:0001634)1.89621031
111Gingival bleeding (HP:0000225)1.89366312
112Eczematoid dermatitis (HP:0000976)1.85958902
113Abnormality of fatty-acid metabolism (HP:0004359)1.83882587
114Ragged-red muscle fibers (HP:0003200)1.83765068
115Neck muscle weakness (HP:0000467)1.82540977
116Hematochezia (HP:0002573)1.81189468
117Difficulty climbing stairs (HP:0003551)1.81092750
118Hyperacusis (HP:0010780)1.80434043
119Wrist flexion contracture (HP:0001239)1.79737576
120Hamartoma of the eye (HP:0010568)1.79026725
121Ulnar bowing (HP:0003031)1.78312225
122Enlarged penis (HP:0000040)1.78144565
123Osteomyelitis (HP:0002754)1.77907305
124Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.77464623
125Back pain (HP:0003418)1.77452507
126Frequent falls (HP:0002359)1.77434548
127Peritonitis (HP:0002586)1.77309749
128EMG: neuropathic changes (HP:0003445)1.76481349
129Round ear (HP:0100830)1.75913567
130Gastrointestinal carcinoma (HP:0002672)1.75788329
131Malignant gastrointestinal tract tumors (HP:0006749)1.75788329
132Visceral angiomatosis (HP:0100761)1.75473018
133Neonatal death (HP:0003811)1.75387301
134Camptodactyly of toe (HP:0001836)1.75322607
135Rimmed vacuoles (HP:0003805)1.75067788
136Acute hepatic failure (HP:0006554)1.72653858
137Recurrent abscess formation (HP:0002722)1.72643428
138Abnormality of aromatic amino acid family metabolism (HP:0004338)1.72175808
139Abnormality of the musculature of the pelvis (HP:0001469)1.72119527
140Abnormality of the hip-girdle musculature (HP:0001445)1.72119527
141Polycythemia (HP:0001901)1.72083653
142* Aneurysm (HP:0002617)1.71888971
143Dysmetric saccades (HP:0000641)1.71650959
144Hemangiomatosis (HP:0007461)1.70904779
145Abnormality of serine family amino acid metabolism (HP:0010894)1.70860457
146Abnormality of glycine metabolism (HP:0010895)1.70860457
147Hand muscle atrophy (HP:0009130)1.70462358
148Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70296755
149Anorexia (HP:0002039)1.68889463
150* Lipoatrophy (HP:0100578)1.68768952
151Toxemia of pregnancy (HP:0100603)1.68752606
152Abnormality of the astrocytes (HP:0100707)1.68051735
153Astrocytoma (HP:0009592)1.68051735
154Multiple enchondromatosis (HP:0005701)1.67698770
155Abnormality of the foot musculature (HP:0001436)1.67350307
156Fibroma (HP:0010614)1.67202568
157Abnormal cartilage morphology (HP:0002763)1.66965714
158Myopathic facies (HP:0002058)1.66176675
159Abnormality of the calcaneus (HP:0008364)1.65927276
160Bowel incontinence (HP:0002607)1.65867004
161Colitis (HP:0002583)1.65514314
162Increased density of long bones (HP:0006392)1.65473371
163Papillary thyroid carcinoma (HP:0002895)1.64961817
164Ankle clonus (HP:0011448)1.64939782
165Hepatocellular carcinoma (HP:0001402)1.63384214
166Sepsis (HP:0100806)1.63046122
167Persistence of primary teeth (HP:0006335)1.62899214
168Onion bulb formation (HP:0003383)1.62099733
169Fibrous tissue neoplasm (HP:0012316)1.62000304
170Viral hepatitis (HP:0006562)1.60560839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.20557754
2PKN23.71012358
3EEF2K3.43785460
4TTN3.23355991
5LATS13.08946001
6PRPF4B3.07659432
7RIPK42.89624848
8MAP3K102.70231365
9IRAK42.54170771
10BLK2.31757259
11LATS22.15514117
12SIK12.10209918
13EPHA31.97182611
14TAOK11.95375896
15NEK21.91600420
16ERN11.69775647
17PDGFRA1.66423727
18CDK121.63762207
19STK38L1.63070619
20FGFR41.61928365
21SIK31.61736664
22ZAP701.61276115
23PTK61.60469158
24TNK21.47759949
25RIPK11.47325704
26STK101.46273810
27BRD41.46030345
28MAP2K31.45075598
29STK31.42379276
30FES1.42027478
31SMG11.42000292
32ERBB41.41869914
33CAMK1D1.39055110
34MAPKAPK31.34419163
35MAP2K41.32744933
36BCKDK1.28444145
37* HCK1.27790453
38RPS6KB21.27686043
39SGK31.26848031
40FGR1.24523030
41TYK21.23557139
42IRAK11.21714861
43BTK1.20988453
44DMPK1.20078962
45MAP3K141.17965481
46MELK1.14931115
47ACVR1B1.14803816
48IKBKE1.14746738
49YES11.09396816
50MAP3K11.08048381
51PHKG21.05598662
52PHKG11.05598662
53TYRO31.04345301
54IRAK21.04205694
55MTOR1.03833410
56SGK21.02355976
57LRRK21.01696595
58CDK41.01016483
59CDK90.96074456
60RPS6KA40.95761895
61MARK30.95362586
62FLT30.93058395
63MAP3K60.92757421
64CDC70.91880916
65CDK60.91858544
66MAPK110.91812796
67PIK3CG0.90901862
68TESK20.90640216
69MAP3K80.90240509
70MAP3K70.89398530
71MAP3K20.89346450
72NEK10.87698747
73TTK0.87630487
74OBSCN0.87555969
75CAMK1G0.86717803
76MAP4K10.86244031
77ITK0.84551459
78SYK0.83670393
79TBK10.82742208
80JAK30.81260695
81RPS6KC10.77594670
82RPS6KL10.77594670
83TRPM70.77327264
84PDGFRB0.77141306
85SIK20.77047048
86HIPK20.74996781
87CAMK40.74660448
88TXK0.73388182
89MAP3K30.70522744
90PAK40.69907822
91ICK0.69756814
92STK40.69326241
93EPHB10.67369551
94* LYN0.65595530
95* PRKAA10.65031657
96RPS6KA60.64712667
97LCK0.63915136
98SGK4940.63277365
99SGK2230.63277365
100LMTK20.61643930
101CSK0.60587454
102ERBB20.60051317
103TAOK30.58870750
104CSF1R0.58738009
105* PRKAA20.58648816
106PDPK10.58573583
107* KSR20.58375746
108RET0.58170500
109STK380.58134627
110PDK10.57826918
111MAPK70.57605188
112PTK20.57589292
113JAK10.57024291
114FGFR30.56268444
115CDK190.55977100
116RPS6KA20.55273054
117DYRK30.54613979
118NEK90.54376535
119MAPK120.52483236
120PIM10.52099342
121DYRK1B0.51848221
122MAP2K70.51289695
123MAP3K90.51034209
124MAP3K130.48454594
125MAP3K50.47566274
126CHEK20.46557565
127PAK20.46183552
128ALK0.45920974
129STK240.45596746
130NLK0.44779343
131FGFR20.44733775
132TAOK20.44512149
133ILK0.44490550
134* JAK20.44168576
135CHUK0.43675514
136RPS6KA10.43362560
137DDR20.43087820
138PRKD10.42330010
139MAP2K20.42086442
140CLK10.42024163
141TGFBR10.41912373
142CDC42BPA0.41628848
143FGFR10.40616757
144AKT20.39947859
145GRK60.39911013
146WNK10.38705681
147MARK20.38491805
148MAP3K110.37230712
149PRKD20.36297707

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.75647185
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.63051562
3Fatty acid degradation_Homo sapiens_hsa000712.33707078
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32307483
5Arginine biosynthesis_Homo sapiens_hsa002202.21708555
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.15931669
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.00306855
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.99494961
9Lysine degradation_Homo sapiens_hsa003101.96757919
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95090996
11* Non-small cell lung cancer_Homo sapiens_hsa052231.79510526
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.76659605
13Measles_Homo sapiens_hsa051621.75850530
14Staphylococcus aureus infection_Homo sapiens_hsa051501.75307620
15* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71516990
16Toll-like receptor signaling pathway_Homo sapiens_hsa046201.66251996
17PPAR signaling pathway_Homo sapiens_hsa033201.60205208
18Propanoate metabolism_Homo sapiens_hsa006401.58888438
19Complement and coagulation cascades_Homo sapiens_hsa046101.58527416
20* T cell receptor signaling pathway_Homo sapiens_hsa046601.57311162
21* Tuberculosis_Homo sapiens_hsa051521.56972969
22Fatty acid metabolism_Homo sapiens_hsa012121.55782341
23Insulin resistance_Homo sapiens_hsa049311.46550296
24Viral myocarditis_Homo sapiens_hsa054161.45262921
25Tryptophan metabolism_Homo sapiens_hsa003801.44163243
26* Jak-STAT signaling pathway_Homo sapiens_hsa046301.44073125
27* Neurotrophin signaling pathway_Homo sapiens_hsa047221.41079562
28Selenocompound metabolism_Homo sapiens_hsa004501.35101737
29Carbon metabolism_Homo sapiens_hsa012001.34517180
30* Chemokine signaling pathway_Homo sapiens_hsa040621.34353165
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34326766
32Biosynthesis of amino acids_Homo sapiens_hsa012301.34197275
33Caffeine metabolism_Homo sapiens_hsa002321.31669764
34* Influenza A_Homo sapiens_hsa051641.28189365
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.24026333
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21644751
37Shigellosis_Homo sapiens_hsa051311.19615784
38Primary immunodeficiency_Homo sapiens_hsa053401.17165124
39* Hepatitis C_Homo sapiens_hsa051601.16712029
40* Chronic myeloid leukemia_Homo sapiens_hsa052201.16478519
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13386989
42beta-Alanine metabolism_Homo sapiens_hsa004101.13070589
43Malaria_Homo sapiens_hsa051441.11585001
44AMPK signaling pathway_Homo sapiens_hsa041521.11070958
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10756655
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.08629833
47mTOR signaling pathway_Homo sapiens_hsa041501.08585307
48Notch signaling pathway_Homo sapiens_hsa043301.07393873
49* Pancreatic cancer_Homo sapiens_hsa052121.05711297
50Small cell lung cancer_Homo sapiens_hsa052221.05280850
51Adherens junction_Homo sapiens_hsa045201.05178490
52Butanoate metabolism_Homo sapiens_hsa006501.05143966
53* Choline metabolism in cancer_Homo sapiens_hsa052311.05080566
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02165720
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01889093
56* ErbB signaling pathway_Homo sapiens_hsa040121.01023093
57Thyroid cancer_Homo sapiens_hsa052161.00387525
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98065666
59One carbon pool by folate_Homo sapiens_hsa006700.97262465
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.96979981
61* MicroRNAs in cancer_Homo sapiens_hsa052060.96315633
62Inositol phosphate metabolism_Homo sapiens_hsa005620.96253383
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95491121
64Platelet activation_Homo sapiens_hsa046110.93352161
65* Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.91850207
66Cell cycle_Homo sapiens_hsa041100.91126434
67Phagosome_Homo sapiens_hsa041450.89341889
68Salmonella infection_Homo sapiens_hsa051320.88308159
69* GnRH signaling pathway_Homo sapiens_hsa049120.87278574
70Leishmaniasis_Homo sapiens_hsa051400.86196867
71Fat digestion and absorption_Homo sapiens_hsa049750.84970223
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84626876
73* Prostate cancer_Homo sapiens_hsa052150.82786522
74Osteoclast differentiation_Homo sapiens_hsa043800.80986559
75Endocytosis_Homo sapiens_hsa041440.80670949
76* Insulin signaling pathway_Homo sapiens_hsa049100.80350273
77* Phospholipase D signaling pathway_Homo sapiens_hsa040720.79181722
78Peroxisome_Homo sapiens_hsa041460.78217897
79* Central carbon metabolism in cancer_Homo sapiens_hsa052300.77699769
80Toxoplasmosis_Homo sapiens_hsa051450.77599318
81* Glioma_Homo sapiens_hsa052140.77204981
82Pyruvate metabolism_Homo sapiens_hsa006200.76771029
83* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76688059
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76368342
85Sulfur relay system_Homo sapiens_hsa041220.75772505
86* Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75628123
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75295264
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75177736
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74893458
90Starch and sucrose metabolism_Homo sapiens_hsa005000.74339384
91Dorso-ventral axis formation_Homo sapiens_hsa043200.73829197
92* Colorectal cancer_Homo sapiens_hsa052100.73663672
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72749778
94* Sphingolipid signaling pathway_Homo sapiens_hsa040710.72266003
95Type II diabetes mellitus_Homo sapiens_hsa049300.72206139
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72088080
97Pentose phosphate pathway_Homo sapiens_hsa000300.71907568
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.71439634
99Glycerolipid metabolism_Homo sapiens_hsa005610.70587061
100* Focal adhesion_Homo sapiens_hsa045100.69462847
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68948613
102Bile secretion_Homo sapiens_hsa049760.68396224
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.68025891
104* Proteoglycans in cancer_Homo sapiens_hsa052050.67889279
105HIF-1 signaling pathway_Homo sapiens_hsa040660.67708273
106Dilated cardiomyopathy_Homo sapiens_hsa054140.67451656
107Other glycan degradation_Homo sapiens_hsa005110.66796255
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66510834
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66396750
110p53 signaling pathway_Homo sapiens_hsa041150.66230770
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64405904
112Hippo signaling pathway_Homo sapiens_hsa043900.64405565
113Hematopoietic cell lineage_Homo sapiens_hsa046400.63506363
114* VEGF signaling pathway_Homo sapiens_hsa043700.63213497
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62767574
116Histidine metabolism_Homo sapiens_hsa003400.62716553
117* B cell receptor signaling pathway_Homo sapiens_hsa046620.62485429
118* MAPK signaling pathway_Homo sapiens_hsa040100.62209493
119Amoebiasis_Homo sapiens_hsa051460.61958499
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61730268
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61676227
122Epstein-Barr virus infection_Homo sapiens_hsa051690.61636805
123Circadian rhythm_Homo sapiens_hsa047100.60415905
124TGF-beta signaling pathway_Homo sapiens_hsa043500.59843810
125Pertussis_Homo sapiens_hsa051330.59470237
126* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58538375
127Fatty acid biosynthesis_Homo sapiens_hsa000610.57512282
128* Endometrial cancer_Homo sapiens_hsa052130.57499904
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56914384
130HTLV-I infection_Homo sapiens_hsa051660.56294157
131* Renal cell carcinoma_Homo sapiens_hsa052110.56265925
132* FoxO signaling pathway_Homo sapiens_hsa040680.56264192
133* Acute myeloid leukemia_Homo sapiens_hsa052210.55083080
134* Estrogen signaling pathway_Homo sapiens_hsa049150.54464632
135Viral carcinogenesis_Homo sapiens_hsa052030.53847548
136TNF signaling pathway_Homo sapiens_hsa046680.53656902
137African trypanosomiasis_Homo sapiens_hsa051430.53358363
138Legionellosis_Homo sapiens_hsa051340.53254006
139Glucagon signaling pathway_Homo sapiens_hsa049220.52833045
140Allograft rejection_Homo sapiens_hsa053300.52632947
141* Bladder cancer_Homo sapiens_hsa052190.51862522
142* Hepatitis B_Homo sapiens_hsa051610.51713251
143Phenylalanine metabolism_Homo sapiens_hsa003600.50906416
144Basal cell carcinoma_Homo sapiens_hsa052170.50493183
145* Apoptosis_Homo sapiens_hsa042100.50054385
146Folate biosynthesis_Homo sapiens_hsa007900.50025054
147* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49851843
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49033933
149* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.48990903
150Herpes simplex infection_Homo sapiens_hsa051680.48728076
151NF-kappa B signaling pathway_Homo sapiens_hsa040640.48615232
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48526313
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47835587
154Graft-versus-host disease_Homo sapiens_hsa053320.47247522
155Retinol metabolism_Homo sapiens_hsa008300.45012162
156* Prolactin signaling pathway_Homo sapiens_hsa049170.43092547

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