RAET1K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.01133262
2response to pheromone (GO:0019236)4.62711490
3cullin deneddylation (GO:0010388)3.66611595
4DNA double-strand break processing (GO:0000729)3.55088659
5respiratory chain complex IV assembly (GO:0008535)3.53705903
6replication fork processing (GO:0031297)3.44647010
7regulation of cilium movement (GO:0003352)3.43206542
8protein deneddylation (GO:0000338)3.39947393
9microtubule depolymerization (GO:0007019)3.38774377
10platelet dense granule organization (GO:0060155)3.37143911
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.33695967
12centriole replication (GO:0007099)3.30128847
13protein polyglutamylation (GO:0018095)3.25240554
14rRNA modification (GO:0000154)3.19790865
15establishment of protein localization to mitochondrial membrane (GO:0090151)3.18615056
16regulation of DNA endoreduplication (GO:0032875)3.13716754
17resolution of meiotic recombination intermediates (GO:0000712)3.13698240
18protein K6-linked ubiquitination (GO:0085020)3.12864032
19piRNA metabolic process (GO:0034587)3.10600687
20negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02529964
21regulation of centriole replication (GO:0046599)3.00143712
22cytochrome complex assembly (GO:0017004)2.99499779
23intraciliary transport (GO:0042073)2.96061143
24rRNA methylation (GO:0031167)2.95866318
25regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.95132731
26protein neddylation (GO:0045116)2.92713037
27somatic hypermutation of immunoglobulin genes (GO:0016446)2.90563440
28somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90563440
29chromatin remodeling at centromere (GO:0031055)2.89639832
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.88513483
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.85450897
32regulation of cellular amino acid metabolic process (GO:0006521)2.84937133
33anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.83507901
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.81394682
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81394682
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81394682
37L-fucose catabolic process (GO:0042355)2.80729661
38fucose catabolic process (GO:0019317)2.80729661
39L-fucose metabolic process (GO:0042354)2.80729661
40CENP-A containing nucleosome assembly (GO:0034080)2.80551409
41natural killer cell mediated immunity (GO:0002228)2.80384982
42natural killer cell mediated cytotoxicity (GO:0042267)2.80384982
43DNA catabolic process, exonucleolytic (GO:0000738)2.78869183
44intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78675817
45signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78675817
46synapsis (GO:0007129)2.76426750
47recombinational repair (GO:0000725)2.76424049
48acrosome reaction (GO:0007340)2.75681053
49histone exchange (GO:0043486)2.75668474
50histone H2A acetylation (GO:0043968)2.74245770
51organelle disassembly (GO:1903008)2.73479321
52tRNA methylation (GO:0030488)2.73050657
53mannosylation (GO:0097502)2.72165723
54double-strand break repair via homologous recombination (GO:0000724)2.71400729
55signal transduction involved in cell cycle checkpoint (GO:0072395)2.70665027
56sperm motility (GO:0030317)2.69881104
57L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68276043
58signal transduction involved in DNA damage checkpoint (GO:0072422)2.67823482
59signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67823482
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.66715964
61negative regulation of ligase activity (GO:0051352)2.66715964
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64776449
63regulation of hexokinase activity (GO:1903299)2.64455679
64regulation of glucokinase activity (GO:0033131)2.64455679
65ribonucleoprotein complex disassembly (GO:0032988)2.64392123
66epithelial cilium movement (GO:0003351)2.64012965
67spermatid nucleus differentiation (GO:0007289)2.63860632
68cilium morphogenesis (GO:0060271)2.63363653
69microtubule polymerization or depolymerization (GO:0031109)2.63087449
70protein complex biogenesis (GO:0070271)2.62370687
71mitochondrial respiratory chain complex assembly (GO:0033108)2.61551410
72behavioral response to nicotine (GO:0035095)2.58007036
73negative regulation of DNA-dependent DNA replication (GO:2000104)2.57891434
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.56746737
75nonmotile primary cilium assembly (GO:0035058)2.56622990
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.56607628
77termination of RNA polymerase III transcription (GO:0006386)2.56607628
78negative regulation of cell cycle G2/M phase transition (GO:1902750)2.56230971
79protein prenylation (GO:0018342)2.54926285
80prenylation (GO:0097354)2.54926285
81protein heterotetramerization (GO:0051290)2.54691158
82DNA damage response, detection of DNA damage (GO:0042769)2.54095716
83DNA replication checkpoint (GO:0000076)2.51670949
84adaptation of signaling pathway (GO:0023058)2.50953422
85ketone body metabolic process (GO:1902224)2.50043871
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.48568691
87somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.48505927
88isotype switching (GO:0045190)2.48505927
89somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.48505927
90mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.47684978
91lactate metabolic process (GO:0006089)2.46255419
92maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.45906355
93regulation of meiosis I (GO:0060631)2.45269188
94peptidyl-histidine modification (GO:0018202)2.45252809
95pseudouridine synthesis (GO:0001522)2.44980277
96attachment of spindle microtubules to kinetochore (GO:0008608)2.44567986
97positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.40263668
98DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.39392988
99male meiosis (GO:0007140)2.39281149
100NADH dehydrogenase complex assembly (GO:0010257)2.39003685

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13013073
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.47839805
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.44043685
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.18045876
5ZNF274_21170338_ChIP-Seq_K562_Hela3.14823809
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.98522571
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78691541
8ELK1_19687146_ChIP-ChIP_HELA_Human2.56499854
9FUS_26573619_Chip-Seq_HEK293_Human2.53096251
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49790256
11VDR_22108803_ChIP-Seq_LS180_Human2.34047331
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.27404916
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18500772
14EWS_26573619_Chip-Seq_HEK293_Human2.17804689
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11937762
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.10510381
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02096676
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.01786822
19E2F7_22180533_ChIP-Seq_HELA_Human1.99967573
20VDR_23849224_ChIP-Seq_CD4+_Human1.95265102
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.92217325
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91030720
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90626007
24GBX2_23144817_ChIP-Seq_PC3_Human1.90006340
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.89885955
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84768485
27P300_19829295_ChIP-Seq_ESCs_Human1.84673615
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82237660
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.71849787
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69833996
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64807320
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60184997
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59747880
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.58412190
35MYC_18940864_ChIP-ChIP_HL60_Human1.57891793
36PADI4_21655091_ChIP-ChIP_MCF-7_Human1.55899767
37IGF1R_20145208_ChIP-Seq_DFB_Human1.54774778
38FOXP3_21729870_ChIP-Seq_TREG_Human1.53298242
39TAF15_26573619_Chip-Seq_HEK293_Human1.52065334
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49126260
41CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46821240
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40322624
43ER_23166858_ChIP-Seq_MCF-7_Human1.38515756
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38068084
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.37488821
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36985130
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33018166
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32556125
49EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32083819
50MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29759867
51IRF1_19129219_ChIP-ChIP_H3396_Human1.27815194
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26746711
53TP53_22573176_ChIP-Seq_HFKS_Human1.24668499
54SOX2_19829295_ChIP-Seq_ESCs_Human1.23122783
55NANOG_19829295_ChIP-Seq_ESCs_Human1.23122783
56RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.22680075
57CBP_20019798_ChIP-Seq_JUKART_Human1.22262193
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22262193
59GABP_19822575_ChIP-Seq_HepG2_Human1.20521047
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.19898628
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.19143498
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18945072
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16223159
64DCP1A_22483619_ChIP-Seq_HELA_Human1.12035551
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.11959884
66SMAD4_21799915_ChIP-Seq_A2780_Human1.11597203
67KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11374707
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.09968362
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.08199130
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08199130
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06974197
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06970170
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06334677
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06334677
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05325344
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.05258127
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05113091
78AR_25329375_ChIP-Seq_VCAP_Human1.04597134
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.04111796
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.03514792
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01713529
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.01376325
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01138297
84TTF2_22483619_ChIP-Seq_HELA_Human1.00855380
85PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99933805
86E2F1_18555785_ChIP-Seq_MESCs_Mouse0.99660179
87TCF4_22108803_ChIP-Seq_LS180_Human0.99451572
88* STAT3_23295773_ChIP-Seq_U87_Human0.99256029
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.99140385
90SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98482382
91MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97428106
92AR_20517297_ChIP-Seq_VCAP_Human0.95999753
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.93871334
94DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93313090
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92917993
96NOTCH1_21737748_ChIP-Seq_TLL_Human0.92679008
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.92557146
98NANOG_16153702_ChIP-ChIP_HESCs_Human0.91628413
99POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91310066
100FOXA1_21572438_ChIP-Seq_LNCaP_Human0.91137227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.39166728
2MP0002102_abnormal_ear_morphology3.75057540
3MP0008057_abnormal_DNA_replication3.17096097
4MP0006072_abnormal_retinal_apoptosis3.05487934
5MP0008877_abnormal_DNA_methylation2.87656021
6MP0002938_white_spotting2.70361741
7MP0009697_abnormal_copulation2.67262908
8MP0003136_yellow_coat_color2.59877323
9MP0010094_abnormal_chromosome_stability2.52652560
10MP0008058_abnormal_DNA_repair2.46217225
11MP0005253_abnormal_eye_physiology2.18644696
12MP0003693_abnormal_embryo_hatching2.18309929
13MP0001529_abnormal_vocalization2.16695217
14MP0003195_calcinosis1.86051125
15MP0005551_abnormal_eye_electrophysiolog1.80331252
16MP0003718_maternal_effect1.71174955
17MP0005408_hypopigmentation1.69942422
18MP0003950_abnormal_plasma_membrane1.68858649
19MP0005075_abnormal_melanosome_morpholog1.65994383
20MP0003787_abnormal_imprinting1.58371166
21MP0001984_abnormal_olfaction1.54065064
22MP0002234_abnormal_pharynx_morphology1.53650203
23MP0004133_heterotaxia1.53469989
24MP0003880_abnormal_central_pattern1.53359092
25MP0002736_abnormal_nociception_after1.52674369
26MP0003121_genomic_imprinting1.52061306
27MP0005410_abnormal_fertilization1.51517096
28MP0003077_abnormal_cell_cycle1.50247055
29MP0003937_abnormal_limbs/digits/tail_de1.49492925
30MP0005084_abnormal_gallbladder_morpholo1.43521534
31MP0002095_abnormal_skin_pigmentation1.43477373
32MP0010030_abnormal_orbit_morphology1.43396862
33MP0006054_spinal_hemorrhage1.37406631
34MP0003122_maternal_imprinting1.37177374
35MP0002751_abnormal_autonomic_nervous1.35010617
36MP0005377_hearing/vestibular/ear_phenot1.34136916
37MP0003878_abnormal_ear_physiology1.34136916
38MP0004957_abnormal_blastocyst_morpholog1.34116137
39MP0002282_abnormal_trachea_morphology1.33096796
40MP0003011_delayed_dark_adaptation1.33051807
41MP0001293_anophthalmia1.32609506
42MP0008932_abnormal_embryonic_tissue1.32427066
43MP0003646_muscle_fatigue1.29147078
44MP0001929_abnormal_gametogenesis1.27458396
45MP0003186_abnormal_redox_activity1.27360867
46MP0005171_absent_coat_pigmentation1.23070351
47MP0001485_abnormal_pinna_reflex1.22733548
48MP0001324_abnormal_eye_pigmentation1.18600219
49MP0003786_premature_aging1.18568736
50MP0003283_abnormal_digestive_organ1.17828900
51MP0002876_abnormal_thyroid_physiology1.16784839
52MP0001764_abnormal_homeostasis1.15912537
53MP0005187_abnormal_penis_morphology1.14642472
54MP0005391_vision/eye_phenotype1.13041002
55MP0000569_abnormal_digit_pigmentation1.12730136
56MP0000647_abnormal_sebaceous_gland1.11483388
57MP0001968_abnormal_touch/_nociception1.10694100
58MP0002090_abnormal_vision1.10126259
59MP0006292_abnormal_olfactory_placode1.10009858
60MP0002233_abnormal_nose_morphology1.08731501
61MP0000516_abnormal_urinary_system1.08164917
62MP0005367_renal/urinary_system_phenotyp1.08164917
63MP0003698_abnormal_male_reproductive1.07046097
64MP0010678_abnormal_skin_adnexa1.06504566
65MP0006036_abnormal_mitochondrial_physio1.04209149
66MP0002210_abnormal_sex_determination1.04004576
67MP0003111_abnormal_nucleus_morphology0.99281042
68MP0000653_abnormal_sex_gland0.97826129
69MP0002928_abnormal_bile_duct0.97309057
70MP0003755_abnormal_palate_morphology0.94986663
71MP0002837_dystrophic_cardiac_calcinosis0.93768911
72MP0005195_abnormal_posterior_eye0.92500000
73MP0008789_abnormal_olfactory_epithelium0.92056538
74MP0004924_abnormal_behavior0.91497991
75MP0005386_behavior/neurological_phenoty0.91497991
76MP0000383_abnormal_hair_follicle0.90749193
77MP0001286_abnormal_eye_development0.90058032
78MP0008872_abnormal_physiological_respon0.89673420
79MP0001145_abnormal_male_reproductive0.87800093
80MP0006035_abnormal_mitochondrial_morpho0.87607847
81MP0003943_abnormal_hepatobiliary_system0.86927147
82MP0008875_abnormal_xenobiotic_pharmacok0.85061367
83MP0001905_abnormal_dopamine_level0.84983863
84MP0000631_abnormal_neuroendocrine_gland0.84650923
85MP0002163_abnormal_gland_morphology0.81869513
86MP0003119_abnormal_digestive_system0.81228119
87MP0001486_abnormal_startle_reflex0.80363055
88MP0002653_abnormal_ependyma_morphology0.80317482
89MP0005395_other_phenotype0.79211548
90MP0001119_abnormal_female_reproductive0.78752240
91MP0009046_muscle_twitch0.76838819
92MP0003806_abnormal_nucleotide_metabolis0.76528021
93MP0000049_abnormal_middle_ear0.75617493
94MP0004142_abnormal_muscle_tone0.74926195
95MP0002752_abnormal_somatic_nervous0.74387376
96MP0004215_abnormal_myocardial_fiber0.73016194
97MP0005174_abnormal_tail_pigmentation0.70848929
98MP0000427_abnormal_hair_cycle0.69911970
99MP0004147_increased_porphyrin_level0.69866635
100MP0010234_abnormal_vibrissa_follicle0.68401818

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)3.63862162
2Molar tooth sign on MRI (HP:0002419)3.63862162
3Pancreatic cysts (HP:0001737)3.43682421
4Pancreatic fibrosis (HP:0100732)3.37842551
5Volvulus (HP:0002580)3.12564927
6True hermaphroditism (HP:0010459)3.11841059
7Acute encephalopathy (HP:0006846)3.03113721
8Acute necrotizing encephalopathy (HP:0006965)3.00123407
9Medial flaring of the eyebrow (HP:0010747)2.94934107
10Chronic hepatic failure (HP:0100626)2.85776530
11Abnormality of the labia minora (HP:0012880)2.85020693
12Intestinal atresia (HP:0011100)2.84802051
13Nephronophthisis (HP:0000090)2.73749713
14Progressive macrocephaly (HP:0004481)2.66075914
15Abnormal mitochondria in muscle tissue (HP:0008316)2.57161418
16Bifid tongue (HP:0010297)2.56018347
17Congenital primary aphakia (HP:0007707)2.54722677
18Gait imbalance (HP:0002141)2.45965738
19Pendular nystagmus (HP:0012043)2.45123208
20Mitochondrial inheritance (HP:0001427)2.44027277
21Increased CSF lactate (HP:0002490)2.43695628
223-Methylglutaconic aciduria (HP:0003535)2.43556434
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.43542487
24Abnormality of the ileum (HP:0001549)2.39041084
25Nephrogenic diabetes insipidus (HP:0009806)2.36880826
26Hypoplasia of the fovea (HP:0007750)2.34993274
27Aplasia/Hypoplasia of the fovea (HP:0008060)2.34993274
28Abnormality of the renal medulla (HP:0100957)2.34276409
29Hepatocellular necrosis (HP:0001404)2.34219665
30Genital tract atresia (HP:0001827)2.32693557
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.32656892
32Meckel diverticulum (HP:0002245)2.27084706
33Tubulointerstitial nephritis (HP:0001970)2.26219632
34Chromsome breakage (HP:0040012)2.24735184
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.24138396
36Vaginal atresia (HP:0000148)2.23779691
37Cystic liver disease (HP:0006706)2.21803625
38Short tibia (HP:0005736)2.21398986
39Ectopic kidney (HP:0000086)2.21285426
40Hypothermia (HP:0002045)2.20409421
41Colon cancer (HP:0003003)2.19508916
42Attenuation of retinal blood vessels (HP:0007843)2.18900100
43Hepatic necrosis (HP:0002605)2.16880257
44Preaxial hand polydactyly (HP:0001177)2.15635988
45Aplasia/Hypoplasia of the tibia (HP:0005772)2.14926186
46Oligodactyly (hands) (HP:0001180)2.14625298
47Median cleft lip (HP:0000161)2.14505989
48Abnormal biliary tract physiology (HP:0012439)2.12142266
49Bile duct proliferation (HP:0001408)2.12142266
50Abnormality of the renal cortex (HP:0011035)2.11462963
51Postaxial foot polydactyly (HP:0001830)2.10366639
52Sclerocornea (HP:0000647)2.10346872
53Anencephaly (HP:0002323)2.10239684
54Abnormality of macular pigmentation (HP:0008002)2.09745649
55Gastrointestinal atresia (HP:0002589)2.06409903
56Anophthalmia (HP:0000528)2.05579976
57Birth length less than 3rd percentile (HP:0003561)2.04923886
58Duodenal stenosis (HP:0100867)2.02690833
59Small intestinal stenosis (HP:0012848)2.02690833
60Degeneration of anterior horn cells (HP:0002398)2.02520932
61Abnormality of the anterior horn cell (HP:0006802)2.02520932
62Hyperglycinemia (HP:0002154)2.00112711
63Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99425645
64Abnormality of the fovea (HP:0000493)1.96121279
65Occipital encephalocele (HP:0002085)1.95871162
66Abnormal lung lobation (HP:0002101)1.94816822
67Abnormality of glycolysis (HP:0004366)1.94374712
68Ependymoma (HP:0002888)1.93533652
69Abnormality of the duodenum (HP:0002246)1.92239389
70Postaxial hand polydactyly (HP:0001162)1.90730649
71Stenosis of the external auditory canal (HP:0000402)1.90439007
72Optic disc pallor (HP:0000543)1.88782324
73Abnormality of the preputium (HP:0100587)1.88620267
74Cerebral edema (HP:0002181)1.87913020
75Abnormality of chromosome stability (HP:0003220)1.87656354
76Sloping forehead (HP:0000340)1.87606100
77Congenital stationary night blindness (HP:0007642)1.86972513
78Astigmatism (HP:0000483)1.85154778
79Neoplasm of the adrenal cortex (HP:0100641)1.82555049
80Abnormality of methionine metabolism (HP:0010901)1.82304452
81Astrocytoma (HP:0009592)1.81130480
82Abnormality of the astrocytes (HP:0100707)1.81130480
83Horseshoe kidney (HP:0000085)1.79782033
84Supernumerary spleens (HP:0009799)1.78932749
85Increased serum lactate (HP:0002151)1.77159367
86Increased serum pyruvate (HP:0003542)1.75807302
87Poor coordination (HP:0002370)1.75057501
88Methylmalonic acidemia (HP:0002912)1.74042629
89Facial cleft (HP:0002006)1.73493749
90Dandy-Walker malformation (HP:0001305)1.72269628
91Aganglionic megacolon (HP:0002251)1.70244532
92Small hand (HP:0200055)1.70106275
93Multicystic kidney dysplasia (HP:0000003)1.69678672
94Oculomotor apraxia (HP:0000657)1.68170042
95Renal cortical cysts (HP:0000803)1.66963841
96Tubulointerstitial abnormality (HP:0001969)1.66437197
97Hypoplastic pelvis (HP:0008839)1.66420152
98Thyroiditis (HP:0100646)1.65783350
99Tubular atrophy (HP:0000092)1.65061408
100Glioma (HP:0009733)1.64042957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM282.92299206
2EIF2AK32.80295902
3INSRR2.74385884
4FRK2.68442486
5NUAK12.45965909
6BMPR1B2.31598299
7MKNK22.26162844
8WEE12.19711630
9VRK22.16452171
10STK162.09794660
11CASK2.08907766
12BUB12.07881283
13BRSK22.06312022
14BCR2.04964959
15SRPK12.02458643
16PLK22.01494933
17PNCK2.01172584
18ZAK1.99318432
19WNK31.92744262
20PLK31.89869565
21ERBB31.88256799
22PLK41.88208308
23MST41.84071582
24MAP3K41.71809871
25MAP4K21.68479500
26MKNK11.55605177
27NEK11.52056525
28MAP3K121.48086558
29STK391.42952762
30VRK11.42434680
31TSSK61.42039157
32GRK11.36392658
33WNK41.34062516
34EIF2AK11.31837861
35CSNK1G11.30719012
36CSNK1G31.25792115
37TNIK1.24919291
38MAP2K71.23508104
39MAPK131.18171388
40CSNK1G21.14562381
41PLK11.13958263
42PAK31.11346708
43STK38L1.10302814
44OXSR11.06056086
45BRSK11.05587575
46EPHA41.03948215
47TIE11.03445927
48CDC71.03123275
49SIK31.02514331
50CSNK1A1L1.01643253
51STK30.91445663
52CDK80.89710108
53ATR0.85677238
54ACVR1B0.82869554
55ADRBK20.82210221
56TGFBR10.82081469
57DYRK20.81770451
58LIMK10.80435022
59PINK10.79335858
60CCNB10.77688527
61TTK0.76581894
62MUSK0.76106797
63PTK2B0.73291635
64MET0.71806198
65PRKCG0.69934696
66EIF2AK20.69171904
67MST1R0.68852498
68PRKCE0.68505858
69FER0.67782489
70PBK0.66594454
71BCKDK0.64691428
72AURKB0.64033369
73TAF10.62988157
74CHEK20.62035326
75FLT30.61054879
76MAPKAPK50.58975541
77MARK10.58526850
78ATM0.56417600
79MINK10.56389502
80STK240.54888616
81LMTK20.53923935
82KDR0.53237979
83RPS6KA40.45149121
84PRKCI0.44953733
85FGFR20.44222726
86PRKCQ0.42881459
87PDK20.42412359
88CSNK2A10.40456853
89BRD40.39380908
90PKN10.38288964
91CHEK10.37756292
92CSNK1A10.35279141
93CSNK1E0.32256695
94DYRK30.31488067
95ADRBK10.31105325
96CDK70.30963073
97CSNK2A20.30878544
98FGFR10.30051547
99MAP2K40.29128094
100GRK50.28713953

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.90870232
2Proteasome_Homo sapiens_hsa030503.72200657
3Non-homologous end-joining_Homo sapiens_hsa034502.89629968
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.82422271
5RNA polymerase_Homo sapiens_hsa030202.48564617
6Mismatch repair_Homo sapiens_hsa034302.45745714
7Fanconi anemia pathway_Homo sapiens_hsa034602.40628505
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34869423
9Oxidative phosphorylation_Homo sapiens_hsa001902.25577183
10Homologous recombination_Homo sapiens_hsa034402.17233078
11Basal transcription factors_Homo sapiens_hsa030222.00653860
12Parkinsons disease_Homo sapiens_hsa050122.00392841
13DNA replication_Homo sapiens_hsa030301.99747868
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98702076
15Propanoate metabolism_Homo sapiens_hsa006401.84715244
16RNA transport_Homo sapiens_hsa030131.84299930
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82500043
18Base excision repair_Homo sapiens_hsa034101.78944586
19Butanoate metabolism_Homo sapiens_hsa006501.73672615
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72862351
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.67949867
22Steroid biosynthesis_Homo sapiens_hsa001001.67756102
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65175414
24RNA degradation_Homo sapiens_hsa030181.62113936
25Huntingtons disease_Homo sapiens_hsa050161.60406097
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.53544859
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48944952
28Nucleotide excision repair_Homo sapiens_hsa034201.43136083
29Fatty acid elongation_Homo sapiens_hsa000621.40755805
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.38545381
31Spliceosome_Homo sapiens_hsa030401.37890082
32Vitamin B6 metabolism_Homo sapiens_hsa007501.36657608
33Selenocompound metabolism_Homo sapiens_hsa004501.36235188
34One carbon pool by folate_Homo sapiens_hsa006701.34787674
35Pyrimidine metabolism_Homo sapiens_hsa002401.30340818
36Folate biosynthesis_Homo sapiens_hsa007901.27214595
37Cell cycle_Homo sapiens_hsa041101.22136039
38Phototransduction_Homo sapiens_hsa047441.20375070
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15261621
40Glutathione metabolism_Homo sapiens_hsa004801.13863023
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13517359
42Alzheimers disease_Homo sapiens_hsa050101.09201939
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07572218
44Nitrogen metabolism_Homo sapiens_hsa009101.06292181
45Purine metabolism_Homo sapiens_hsa002300.99977993
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99342742
47Caffeine metabolism_Homo sapiens_hsa002320.96457338
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91106372
49Oocyte meiosis_Homo sapiens_hsa041140.87797335
50Peroxisome_Homo sapiens_hsa041460.87034325
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83977332
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.82289047
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81436894
54Pyruvate metabolism_Homo sapiens_hsa006200.80721197
55Metabolic pathways_Homo sapiens_hsa011000.80099894
56Tryptophan metabolism_Homo sapiens_hsa003800.75784168
57Sulfur relay system_Homo sapiens_hsa041220.75190080
58Arginine and proline metabolism_Homo sapiens_hsa003300.74114557
59Sulfur metabolism_Homo sapiens_hsa009200.73939549
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73549411
61Fatty acid metabolism_Homo sapiens_hsa012120.72878027
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70745924
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68233773
64Ribosome_Homo sapiens_hsa030100.68199101
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66670332
66Hippo signaling pathway_Homo sapiens_hsa043900.58023354
67p53 signaling pathway_Homo sapiens_hsa041150.57297951
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57204721
69Nicotine addiction_Homo sapiens_hsa050330.56798878
70Fatty acid degradation_Homo sapiens_hsa000710.55910695
71Regulation of autophagy_Homo sapiens_hsa041400.55566849
72mRNA surveillance pathway_Homo sapiens_hsa030150.55071116
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54182492
74Chemical carcinogenesis_Homo sapiens_hsa052040.52589387
75Linoleic acid metabolism_Homo sapiens_hsa005910.51583308
76Retinol metabolism_Homo sapiens_hsa008300.50800696
77Taste transduction_Homo sapiens_hsa047420.49518414
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49266489
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48764806
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48328628
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.48316287
82Hedgehog signaling pathway_Homo sapiens_hsa043400.48162729
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47549700
84Olfactory transduction_Homo sapiens_hsa047400.46451883
85Carbon metabolism_Homo sapiens_hsa012000.45408811
86Collecting duct acid secretion_Homo sapiens_hsa049660.44428940
87Tyrosine metabolism_Homo sapiens_hsa003500.43650368
88Biosynthesis of amino acids_Homo sapiens_hsa012300.43258706
89Basal cell carcinoma_Homo sapiens_hsa052170.42526967
90TGF-beta signaling pathway_Homo sapiens_hsa043500.41811344
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41684932
92N-Glycan biosynthesis_Homo sapiens_hsa005100.41631124
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39383779
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.39067893
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38815355
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37696311
97beta-Alanine metabolism_Homo sapiens_hsa004100.36896628
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35755442
99Fatty acid biosynthesis_Homo sapiens_hsa000610.34099270
100Circadian rhythm_Homo sapiens_hsa047100.29223917

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