RAD52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)7.71128496
2daunorubicin metabolic process (GO:0044597)7.71128496
3polyketide metabolic process (GO:0030638)7.71128496
4aminoglycoside antibiotic metabolic process (GO:0030647)4.52159025
5water-soluble vitamin biosynthetic process (GO:0042364)4.43421197
6behavioral response to nicotine (GO:0035095)4.35371021
7DNA methylation involved in gamete generation (GO:0043046)4.16500731
8regulation of DNA methylation (GO:0044030)4.13375702
9regulation of gene expression by genetic imprinting (GO:0006349)3.89346203
10protein complex biogenesis (GO:0070271)3.76674972
11negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.73245568
12regulation of nuclear cell cycle DNA replication (GO:0033262)3.70966573
13DNA deamination (GO:0045006)3.67019836
14protein polyglutamylation (GO:0018095)3.65639324
15sulfation (GO:0051923)3.54264375
16mitochondrial respiratory chain complex I assembly (GO:0032981)3.51553240
17NADH dehydrogenase complex assembly (GO:0010257)3.51553240
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.51553240
19mitochondrial respiratory chain complex assembly (GO:0033108)3.48803981
20termination of RNA polymerase III transcription (GO:0006386)3.44035197
21transcription elongation from RNA polymerase III promoter (GO:0006385)3.44035197
22regulation of DNA endoreduplication (GO:0032875)3.40017422
23indole-containing compound catabolic process (GO:0042436)3.39596209
24indolalkylamine catabolic process (GO:0046218)3.39596209
25tryptophan catabolic process (GO:0006569)3.39596209
26kinetochore assembly (GO:0051382)3.38416797
27negative regulation of DNA-dependent DNA replication (GO:2000104)3.32293455
28maturation of SSU-rRNA (GO:0030490)3.30157823
29axoneme assembly (GO:0035082)3.23660424
30regulation of hexokinase activity (GO:1903299)3.22738091
31regulation of glucokinase activity (GO:0033131)3.22738091
32poly(A)+ mRNA export from nucleus (GO:0016973)3.18502688
33indolalkylamine metabolic process (GO:0006586)3.14734839
34energy homeostasis (GO:0097009)3.12525523
35kinetochore organization (GO:0051383)3.12324278
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.09004838
37tRNA methylation (GO:0030488)3.07225277
38positive regulation of granulocyte differentiation (GO:0030854)3.06916437
39piRNA metabolic process (GO:0034587)3.03782810
40replication fork processing (GO:0031297)3.02816060
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.02768673
42platelet dense granule organization (GO:0060155)3.02731545
43histone H3-K4 trimethylation (GO:0080182)3.02315818
44kynurenine metabolic process (GO:0070189)3.00248163
45DNA double-strand break processing (GO:0000729)2.98668655
46protein K6-linked ubiquitination (GO:0085020)2.98346174
47tryptophan metabolic process (GO:0006568)2.94621448
48somite development (GO:0061053)2.94558862
49rRNA catabolic process (GO:0016075)2.93188528
50ribosomal small subunit assembly (GO:0000028)2.92137480
51presynaptic membrane assembly (GO:0097105)2.91206516
52L-fucose catabolic process (GO:0042355)2.88158328
53fucose catabolic process (GO:0019317)2.88158328
54L-fucose metabolic process (GO:0042354)2.88158328
55negative regulation of mitotic sister chromatid separation (GO:2000816)2.86505795
56negative regulation of mitotic sister chromatid segregation (GO:0033048)2.86505795
57negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.86505795
58negative regulation of sister chromatid segregation (GO:0033046)2.86505795
59epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.86157259
60response to pheromone (GO:0019236)2.85807431
61limb bud formation (GO:0060174)2.85491829
62preassembly of GPI anchor in ER membrane (GO:0016254)2.84884344
63regulation of mitotic spindle checkpoint (GO:1903504)2.84107834
64regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84107834
65protein K11-linked deubiquitination (GO:0035871)2.83762835
66inositol phosphate catabolic process (GO:0071545)2.83173889
67telomere maintenance via telomerase (GO:0007004)2.80969715
68negative regulation of transcription regulatory region DNA binding (GO:2000678)2.80292534
69telomere maintenance via semi-conservative replication (GO:0032201)2.80063596
70synaptic transmission, glutamatergic (GO:0035249)2.78201361
71GPI anchor metabolic process (GO:0006505)2.76846807
72negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.76792595
73gamma-aminobutyric acid transport (GO:0015812)2.76769644
74regulation of feeding behavior (GO:0060259)2.75876596
75positive regulation of gamma-delta T cell activation (GO:0046645)2.75596106
76cornea development in camera-type eye (GO:0061303)2.75526244
77negative regulation of chromosome segregation (GO:0051985)2.74462565
78synapsis (GO:0007129)2.73667212
79mitotic spindle assembly checkpoint (GO:0007094)2.73604932
80transcription elongation from RNA polymerase I promoter (GO:0006362)2.72411504
81kidney morphogenesis (GO:0060993)2.72409099
82purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.72147459
833-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.72147459
84negative regulation of telomere maintenance (GO:0032205)2.71862353
85regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71522090
86detection of light stimulus involved in visual perception (GO:0050908)2.70272817
87detection of light stimulus involved in sensory perception (GO:0050962)2.70272817
88negative regulation of mast cell activation (GO:0033004)2.70244916
89polyol catabolic process (GO:0046174)2.70199004
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.69676749
91neural tube formation (GO:0001841)2.69159098
92spindle assembly checkpoint (GO:0071173)2.68838815
93prostate gland growth (GO:0060736)2.68434955
94sphingoid metabolic process (GO:0046519)2.68282946
95exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68009294
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.66712810
97reflex (GO:0060004)2.66387500
98regulation of action potential (GO:0098900)2.66082278
99tRNA modification (GO:0006400)2.66013496
100CENP-A containing nucleosome assembly (GO:0034080)2.65618843
101chromatin remodeling at centromere (GO:0031055)2.64997899
102telomere maintenance via telomere lengthening (GO:0010833)2.64910560
103maturation of 5.8S rRNA (GO:0000460)2.64800278
104interferon-gamma production (GO:0032609)2.64610965
105cellular response to interleukin-15 (GO:0071350)2.61955849
106nonmotile primary cilium assembly (GO:0035058)2.61021287
107photoreceptor cell development (GO:0042461)2.60744870
108protein-cofactor linkage (GO:0018065)2.59026942
109cellular response to ATP (GO:0071318)2.57946156
110epithelial cilium movement (GO:0003351)2.57258420
111neuronal action potential (GO:0019228)2.56695292
112retinal ganglion cell axon guidance (GO:0031290)2.56651661
113rRNA modification (GO:0000154)2.55743140
114regulation of respiratory system process (GO:0044065)2.55315704
115protein K11-linked ubiquitination (GO:0070979)2.55302422
116embryonic epithelial tube formation (GO:0001838)2.54838696
117dopamine transport (GO:0015872)2.54745101
118photoreceptor cell maintenance (GO:0045494)2.54425888
119termination of RNA polymerase I transcription (GO:0006363)2.54279321
120genetic imprinting (GO:0071514)2.54258482
121intraciliary transport (GO:0042073)2.54002600
122* recombinational repair (GO:0000725)2.53662760
123centriole assembly (GO:0098534)2.52772748
124adaptation of signaling pathway (GO:0023058)2.52760630
125prenylation (GO:0097354)2.51422997
126protein prenylation (GO:0018342)2.51422997
127* double-strand break repair via homologous recombination (GO:0000724)2.50758315
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50707586
129RNA-dependent DNA replication (GO:0006278)2.49824845
130protein localization to cilium (GO:0061512)2.49113085
131RNA methylation (GO:0001510)2.48671081
132maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.48531328
133cilium morphogenesis (GO:0060271)2.47790304
134ketone body metabolic process (GO:1902224)2.47582186
135inositol phosphate dephosphorylation (GO:0046855)2.47494746
136phosphorylated carbohydrate dephosphorylation (GO:0046838)2.47494746
137regulation of mesoderm development (GO:2000380)2.47395585
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.47378216
139behavioral response to ethanol (GO:0048149)2.46764561
140regulation of cilium movement (GO:0003352)2.46220477
141indole-containing compound metabolic process (GO:0042430)2.45669597
142C-terminal protein amino acid modification (GO:0018410)2.45574491
143DNA integration (GO:0015074)2.45316992
144regulation of hippo signaling (GO:0035330)2.44853269
145proteasome assembly (GO:0043248)2.44210766
146positive regulation of catecholamine secretion (GO:0033605)2.44169586
147cell proliferation in forebrain (GO:0021846)2.44162635
148rRNA methylation (GO:0031167)2.44072866
149presynaptic membrane organization (GO:0097090)2.44013690
150lactate metabolic process (GO:0006089)2.43159531
151reciprocal meiotic recombination (GO:0007131)2.43075514
152reciprocal DNA recombination (GO:0035825)2.43075514
153telomere maintenance via recombination (GO:0000722)2.42687324
154cellular ketone body metabolic process (GO:0046950)2.42390849
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42285712
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42285712
157isotype switching (GO:0045190)2.41791889
158somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.41791889
159mitotic spindle checkpoint (GO:0071174)2.41266746
160respiratory chain complex IV assembly (GO:0008535)2.40526723
161adenosine metabolic process (GO:0046085)2.39789513
162transcription from RNA polymerase I promoter (GO:0006360)2.36052591
163cellular response to interferon-beta (GO:0035458)2.35978889
164positive regulation of T cell mediated cytotoxicity (GO:0001916)2.35308087
165regulation of transcription from RNA polymerase I promoter (GO:0006356)2.34603432
166regulation of T cell mediated cytotoxicity (GO:0001914)2.34502873
167mannosylation (GO:0097502)2.34172976
168natural killer cell activation involved in immune response (GO:0002323)2.34132385
1697-methylguanosine mRNA capping (GO:0006370)2.32060181
170tRNA processing (GO:0008033)2.31670082
171C-terminal protein lipidation (GO:0006501)2.30860119
172DNA synthesis involved in DNA repair (GO:0000731)2.30602306
173regulation of mitotic sister chromatid separation (GO:0010965)2.30180821
174regulation of mitotic sister chromatid segregation (GO:0033047)2.30180821
175regulation of sister chromatid segregation (GO:0033045)2.30180821
176transcription-coupled nucleotide-excision repair (GO:0006283)2.30044874
177transcription initiation from RNA polymerase I promoter (GO:0006361)2.29991090
178RNA capping (GO:0036260)2.29845969
1797-methylguanosine RNA capping (GO:0009452)2.29845969
180DNA replication-independent nucleosome assembly (GO:0006336)2.28937061
181DNA replication-independent nucleosome organization (GO:0034724)2.28937061
182spindle checkpoint (GO:0031577)2.28672915
183regulation of chromatin silencing (GO:0031935)2.26919770
184DNA-dependent DNA replication (GO:0006261)2.26541923
185cytochrome complex assembly (GO:0017004)2.26518027
186chromatin silencing (GO:0006342)2.25089183

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.42700092
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.89965504
3GBX2_23144817_ChIP-Seq_PC3_Human3.52288543
4ZNF274_21170338_ChIP-Seq_K562_Hela3.50267020
5NOTCH1_21737748_ChIP-Seq_TLL_Human3.16492792
6EZH2_22144423_ChIP-Seq_EOC_Human2.90639668
7IRF1_19129219_ChIP-ChIP_H3396_Human2.88044811
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.70207693
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.59252981
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48467634
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36288153
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.35815834
13TAF15_26573619_Chip-Seq_HEK293_Human2.34567757
14FUS_26573619_Chip-Seq_HEK293_Human2.33064845
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.31896925
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.31371779
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.28176927
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.07432423
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.05319281
20EWS_26573619_Chip-Seq_HEK293_Human2.04375130
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03556966
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02653406
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01946998
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.98538521
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.97690363
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92993340
27ER_23166858_ChIP-Seq_MCF-7_Human1.87025882
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82739852
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82125309
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80961067
31* EST1_17652178_ChIP-ChIP_JURKAT_Human1.78730398
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.74804176
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72821855
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72626153
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69332167
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64936694
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.64693708
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62358573
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61453731
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60658816
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60483425
42FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60203701
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59585295
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.58796756
45* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57911290
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56473503
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.56205553
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54572646
49ELK1_19687146_ChIP-ChIP_HELA_Human1.53392859
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.53059840
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52219750
52CBP_20019798_ChIP-Seq_JUKART_Human1.50830972
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.50830972
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50576287
55BCAT_22108803_ChIP-Seq_LS180_Human1.50117587
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50084557
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.48016103
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47085882
59SMAD4_21799915_ChIP-Seq_A2780_Human1.45088136
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44622523
61* ETS1_20019798_ChIP-Seq_JURKAT_Human1.43707027
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.41600107
63TP53_22573176_ChIP-Seq_HFKS_Human1.41451227
64STAT3_23295773_ChIP-Seq_U87_Human1.41172663
65VDR_22108803_ChIP-Seq_LS180_Human1.40835185
66AR_25329375_ChIP-Seq_VCAP_Human1.40350320
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.39834652
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39781737
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38389605
70LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.37840273
71* MYC_18555785_ChIP-Seq_MESCs_Mouse1.37589820
72TCF4_23295773_ChIP-Seq_U87_Human1.37391080
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37291656
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36646617
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35110511
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34049693
77SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33667685
78VDR_23849224_ChIP-Seq_CD4+_Human1.33385582
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31703076
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31686956
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.29945974
82SCL_19346495_ChIP-Seq_HPC-7_Human1.29200480
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.28868724
84NANOG_19829295_ChIP-Seq_ESCs_Human1.28469617
85SOX2_19829295_ChIP-Seq_ESCs_Human1.28469617
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.28275550
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27989183
88P53_22387025_ChIP-Seq_ESCs_Mouse1.27566327
89NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27463389
90* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.26672625
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26455567
92STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25880822
93RNF2_27304074_Chip-Seq_NSC_Mouse1.25534031
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24430894
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23525985
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22347808
97RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22020440
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21145447
99NMYC_18555785_Chip-Seq_ESCs_Mouse1.20909711
100TCF4_22108803_ChIP-Seq_LS180_Human1.20338148
101THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20113858
102STAT3_18555785_Chip-Seq_ESCs_Mouse1.19248757
103E2F1_18555785_Chip-Seq_ESCs_Mouse1.19103330
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18962127
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.18829906
106FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16771399
107FOXA1_25329375_ChIP-Seq_VCAP_Human1.16771399
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16504885
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15842817
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.15798063
111RUNX_20019798_ChIP-Seq_JUKART_Human1.15722197
112IGF1R_20145208_ChIP-Seq_DFB_Human1.15581962
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.15426987
114CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.15201041
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15064633
116FOXP3_21729870_ChIP-Seq_TREG_Human1.14932445
117RUNX2_22187159_ChIP-Seq_PCA_Human1.14145659
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14085842
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.13820322
120TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13746922
121CMYC_18555785_Chip-Seq_ESCs_Mouse1.13113468
122FLI1_21867929_ChIP-Seq_TH2_Mouse1.12066419
123* SPI1_23547873_ChIP-Seq_NB4_Human1.12023390
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11991783
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11991783
126P300_19829295_ChIP-Seq_ESCs_Human1.11745696
127NCOR_22424771_ChIP-Seq_293T_Human1.11257592
128POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09142424
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08896469
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08316033
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.06282870
132* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04712984
133REST_21632747_ChIP-Seq_MESCs_Mouse1.03769267
134E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03753153
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.03444194
136ESRRB_18555785_Chip-Seq_ESCs_Mouse1.03349503
137PU1_27457419_Chip-Seq_LIVER_Mouse1.03285118
138PRDM14_20953172_ChIP-Seq_ESCs_Human1.02111592
139* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02011335
140BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01658699
141AR_20517297_ChIP-Seq_VCAP_Human1.00618299
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00488116
143CDX2_22108803_ChIP-Seq_LS180_Human1.00392477
144AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00330812
145SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99598129
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99563268
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99254345
148MYC_18940864_ChIP-ChIP_HL60_Human0.98320296
149KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97974955
150KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97974955
151KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97974955
152STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97949213
153P300_18555785_Chip-Seq_ESCs_Mouse0.97851691
154ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96541941
155* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.96050471
156KLF4_18555785_Chip-Seq_ESCs_Mouse0.95956961
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.94464473
158TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94209734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation5.63231054
2MP0005670_abnormal_white_adipose3.69588260
3MP0002736_abnormal_nociception_after3.26396347
4MP0000516_abnormal_urinary_system3.15337988
5MP0005367_renal/urinary_system_phenotyp3.15337988
6MP0002735_abnormal_chemical_nociception3.10073525
7MP0002837_dystrophic_cardiac_calcinosis2.81069205
8MP0006292_abnormal_olfactory_placode2.75068759
9MP0001188_hyperpigmentation2.74458468
10MP0003195_calcinosis2.73532782
11MP0005646_abnormal_pituitary_gland2.71301766
12MP0000372_irregular_coat_pigmentation2.58303797
13MP0004859_abnormal_synaptic_plasticity2.53009918
14MP0006072_abnormal_retinal_apoptosis2.39244990
15MP0010094_abnormal_chromosome_stability2.32187372
16* MP0003111_abnormal_nucleus_morphology2.30164902
17MP0001968_abnormal_touch/_nociception2.29179424
18MP0008058_abnormal_DNA_repair2.28587850
19MP0003880_abnormal_central_pattern2.27535888
20MP0005551_abnormal_eye_electrophysiolog2.21080359
21MP0003646_muscle_fatigue2.19431462
22MP0004147_increased_porphyrin_level2.17416466
23MP0001835_abnormal_antigen_presentation2.16459086
24MP0002396_abnormal_hematopoietic_system2.14099924
25MP0002132_abnormal_respiratory_system2.11714640
26MP0002938_white_spotting2.06978210
27MP0005174_abnormal_tail_pigmentation2.04545130
28MP0005253_abnormal_eye_physiology2.01821810
29MP0000015_abnormal_ear_pigmentation1.92516254
30MP0005671_abnormal_response_to1.90266193
31MP0004885_abnormal_endolymph1.86392739
32MP0008872_abnormal_physiological_respon1.85704430
33MP0008260_abnormal_autophagy1.84169561
34MP0008057_abnormal_DNA_replication1.83304642
35MP0000631_abnormal_neuroendocrine_gland1.78789542
36MP0003763_abnormal_thymus_physiology1.77414040
37MP0000569_abnormal_digit_pigmentation1.76868309
38MP0001501_abnormal_sleep_pattern1.75971690
39MP0001984_abnormal_olfaction1.72792054
40MP0002160_abnormal_reproductive_system1.72524726
41MP0003787_abnormal_imprinting1.66163358
42MP0005409_darkened_coat_color1.63214399
43MP0004808_abnormal_hematopoietic_stem1.62273389
44MP0001485_abnormal_pinna_reflex1.47020295
45MP0005389_reproductive_system_phenotype1.46571932
46MP0009785_altered_susceptibility_to1.44945929
47MP0008007_abnormal_cellular_replicative1.43358315
48MP0000427_abnormal_hair_cycle1.38184873
49MP0000566_synostosis1.35997724
50MP0002148_abnormal_hypersensitivity_rea1.35966121
51MP0009780_abnormal_chondrocyte_physiolo1.34121441
52MP0002398_abnormal_bone_marrow1.33251293
53MP0001790_abnormal_immune_system1.30838762
54MP0005387_immune_system_phenotype1.30838762
55MP0002163_abnormal_gland_morphology1.30518314
56MP0002572_abnormal_emotion/affect_behav1.30417329
57MP0005171_absent_coat_pigmentation1.30385830
58MP0005379_endocrine/exocrine_gland_phen1.29230672
59MP0005075_abnormal_melanosome_morpholog1.28926497
60MP0002420_abnormal_adaptive_immunity1.28408864
61MP0001819_abnormal_immune_cell1.27589844
62MP0003011_delayed_dark_adaptation1.27064939
63MP0001440_abnormal_grooming_behavior1.27058055
64MP0002452_abnormal_antigen_presenting1.26653706
65MP0003077_abnormal_cell_cycle1.25413459
66MP0001800_abnormal_humoral_immune1.25113223
67MP0000685_abnormal_immune_system1.24880324
68MP0000749_muscle_degeneration1.23617452
69MP0003136_yellow_coat_color1.21276579
70MP0003283_abnormal_digestive_organ1.20966032
71MP0009745_abnormal_behavioral_response1.20019855
72MP0004145_abnormal_muscle_electrophysio1.19861113
73MP0002234_abnormal_pharynx_morphology1.19278220
74MP0002723_abnormal_immune_serum1.19213423
75MP0002095_abnormal_skin_pigmentation1.19144425
76MP0002102_abnormal_ear_morphology1.18390001
77MP0009333_abnormal_splenocyte_physiolog1.18111689
78MP0002751_abnormal_autonomic_nervous1.17372689
79MP0003123_paternal_imprinting1.16223297
80MP0002272_abnormal_nervous_system1.15176821
81MP0000490_abnormal_crypts_of1.14195488
82MP0002638_abnormal_pupillary_reflex1.13795708
83MP0005084_abnormal_gallbladder_morpholo1.13158259
84MP0002928_abnormal_bile_duct1.12010830
85MP0001545_abnormal_hematopoietic_system1.10410630
86MP0005397_hematopoietic_system_phenotyp1.10410630
87MP0001764_abnormal_homeostasis1.10221759
88MP0004134_abnormal_chest_morphology1.09925748
89MP0000716_abnormal_immune_system1.09705660
90MP0002064_seizures1.09141558
91MP0004510_myositis1.08491052
92MP0008875_abnormal_xenobiotic_pharmacok1.07828090
93MP0002419_abnormal_innate_immunity1.07821383
94MP0002557_abnormal_social/conspecific_i1.06495342
95MP0002067_abnormal_sensory_capabilities1.05610265
96MP0005000_abnormal_immune_tolerance1.04513209
97MP0003122_maternal_imprinting1.03168227
98MP0004215_abnormal_myocardial_fiber1.03017635
99MP0003724_increased_susceptibility_to1.01272372
100MP0000689_abnormal_spleen_morphology1.00782639
101MP0000383_abnormal_hair_follicle1.00546968
102MP0005025_abnormal_response_to0.99615796
103MP0000703_abnormal_thymus_morphology0.99016361
104MP0002138_abnormal_hepatobiliary_system0.98986624
105MP0008995_early_reproductive_senescence0.98911710
106MP0005195_abnormal_posterior_eye0.98355005
107* MP0002429_abnormal_blood_cell0.98333860
108MP0003786_premature_aging0.97421790
109MP0001873_stomach_inflammation0.97362545
110MP0004142_abnormal_muscle_tone0.95676506
111MP0009697_abnormal_copulation0.95287327
112MP0008775_abnormal_heart_ventricle0.95033402
113MP0003693_abnormal_embryo_hatching0.94914469
114MP0001919_abnormal_reproductive_system0.93459016
115MP0002722_abnormal_immune_system0.93393328
116MP0003119_abnormal_digestive_system0.93379913
117MP0000049_abnormal_middle_ear0.92593925
118MP0004924_abnormal_behavior0.92574861
119MP0005386_behavior/neurological_phenoty0.92574861
120MP0004043_abnormal_pH_regulation0.92022593
121MP0003937_abnormal_limbs/digits/tail_de0.90290104
122MP0002063_abnormal_learning/memory/cond0.89832397
123MP0006276_abnormal_autonomic_nervous0.89466813
124MP0006036_abnormal_mitochondrial_physio0.89072715
125MP0001529_abnormal_vocalization0.88533295
126MP0005332_abnormal_amino_acid0.87975151
127MP0005220_abnormal_exocrine_pancreas0.87291276
128MP0005645_abnormal_hypothalamus_physiol0.86590462
129MP0002734_abnormal_mechanical_nocicepti0.86381412
130MP0005187_abnormal_penis_morphology0.85836549
131MP0002653_abnormal_ependyma_morphology0.84111935
132MP0003635_abnormal_synaptic_transmissio0.84051219
133MP0001970_abnormal_pain_threshold0.83897555
134MP0002752_abnormal_somatic_nervous0.82434921
135MP0001929_abnormal_gametogenesis0.82389207
136MP0000653_abnormal_sex_gland0.81610148
137MP0010386_abnormal_urinary_bladder0.80855254
138MP0006035_abnormal_mitochondrial_morpho0.80335257
139MP0001324_abnormal_eye_pigmentation0.79976801
140MP0003878_abnormal_ear_physiology0.79898533
141MP0005377_hearing/vestibular/ear_phenot0.79898533
142MP0005391_vision/eye_phenotype0.79741637
143MP0002876_abnormal_thyroid_physiology0.79293532
144MP0000955_abnormal_spinal_cord0.78769999
145MP0001145_abnormal_male_reproductive0.78414280
146MP0009379_abnormal_foot_pigmentation0.78341980
147MP0002933_joint_inflammation0.77437122
148MP0001293_anophthalmia0.77246471
149MP0003656_abnormal_erythrocyte_physiolo0.71458194
150MP0003121_genomic_imprinting0.71191680
151MP0009046_muscle_twitch0.71051877
152MP0001963_abnormal_hearing_physiology0.62121749
153MP0004957_abnormal_blastocyst_morpholog0.61880288
154MP0001486_abnormal_startle_reflex0.61803395
155MP0003718_maternal_effect0.61161203
156MP0001905_abnormal_dopamine_level0.61088931
157MP0001119_abnormal_female_reproductive0.60440192
158MP0001986_abnormal_taste_sensitivity0.59924803
159MP0008770_decreased_survivor_rate0.55156218
160MP0003941_abnormal_skin_development0.54706646
161MP0002405_respiratory_system_inflammati0.53989912
162* MP0009765_abnormal_xenobiotic_induced0.52954511
163MP0000313_abnormal_cell_death0.52908131
164MP0004133_heterotaxia0.52706998

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.52919878
2Chromsome breakage (HP:0040012)4.26828305
3Pancreatic cysts (HP:0001737)4.18346192
4Pancreatic fibrosis (HP:0100732)4.05146394
5True hermaphroditism (HP:0010459)3.67113444
6Congenital stationary night blindness (HP:0007642)3.48137011
7Molar tooth sign on MRI (HP:0002419)3.43548224
8Abnormality of midbrain morphology (HP:0002418)3.43548224
9Pendular nystagmus (HP:0012043)3.42534175
10Calf muscle hypertrophy (HP:0008981)3.34827974
11Nephronophthisis (HP:0000090)3.29431972
12Poor head control (HP:0002421)3.19202195
13Cerebellar dysplasia (HP:0007033)3.19141500
14Meckel diverticulum (HP:0002245)3.15850428
15Abnormality of the preputium (HP:0100587)3.13428073
16Abnormality of DNA repair (HP:0003254)3.11934174
17Hypoplasia of the pons (HP:0012110)3.08010730
18Nonprogressive disorder (HP:0003680)3.06178712
19Febrile seizures (HP:0002373)3.02377218
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.99940627
21Muscle hypertrophy of the lower extremities (HP:0008968)2.98189307
22Abnormality of the ileum (HP:0001549)2.95989302
23Methylmalonic acidemia (HP:0002912)2.95897298
24Abnormality of the pons (HP:0007361)2.95035870
25Microvesicular hepatic steatosis (HP:0001414)2.94582328
26Clubbing of toes (HP:0100760)2.90751958
27Medial flaring of the eyebrow (HP:0010747)2.88698412
28Severe visual impairment (HP:0001141)2.87931593
29Abnormality of the renal medulla (HP:0100957)2.86737741
30Abolished electroretinogram (ERG) (HP:0000550)2.84623553
31Abnormality of chromosome stability (HP:0003220)2.80471617
32Abnormality of the renal cortex (HP:0011035)2.79988444
33Abnormality of the heme biosynthetic pathway (HP:0010472)2.74887849
34Aplastic anemia (HP:0001915)2.74697362
35Type II lissencephaly (HP:0007260)2.72633079
36Gaze-evoked nystagmus (HP:0000640)2.69094441
37Pelvic girdle muscle weakness (HP:0003749)2.65913151
38Increased corneal curvature (HP:0100692)2.62261033
39Keratoconus (HP:0000563)2.62261033
40Myelodysplasia (HP:0002863)2.59562041
41Weak cry (HP:0001612)2.58856771
42Severe combined immunodeficiency (HP:0004430)2.58005264
43Decreased central vision (HP:0007663)2.56921431
44Hypoventilation (HP:0002791)2.53089284
45Attenuation of retinal blood vessels (HP:0007843)2.52087192
46Protruding tongue (HP:0010808)2.51342893
47Progressive macrocephaly (HP:0004481)2.51337943
48Renal cortical cysts (HP:0000803)2.50499682
49Duplicated collecting system (HP:0000081)2.50094725
50Focal motor seizures (HP:0011153)2.48595497
51Birth length less than 3rd percentile (HP:0003561)2.48230331
52Cystic liver disease (HP:0006706)2.47276712
53Bone marrow hypocellularity (HP:0005528)2.46822043
54Shoulder girdle muscle weakness (HP:0003547)2.46253450
55Chorioretinal atrophy (HP:0000533)2.43199181
56Chronic hepatic failure (HP:0100626)2.42884170
57Reticulocytopenia (HP:0001896)2.42541725
58Acute necrotizing encephalopathy (HP:0006965)2.40970406
59Abnormality of the hip-girdle musculature (HP:0001445)2.40268988
60Abnormality of the musculature of the pelvis (HP:0001469)2.40268988
61Hemiparesis (HP:0001269)2.36285608
62Mitochondrial inheritance (HP:0001427)2.34192385
63Abnormal hair whorl (HP:0010721)2.33875203
64Neoplasm of the adrenal cortex (HP:0100641)2.33134342
65Methylmalonic aciduria (HP:0012120)2.32191522
66Hyperventilation (HP:0002883)2.31157883
673-Methylglutaconic aciduria (HP:0003535)2.30707832
68Thyroiditis (HP:0100646)2.29221589
69Type 2 muscle fiber atrophy (HP:0003554)2.28584305
70Increased CSF lactate (HP:0002490)2.28427837
71Abnormal rod and cone electroretinograms (HP:0008323)2.27289050
72Abnormality of the renal collecting system (HP:0004742)2.27213206
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24503294
74Abnormality of alanine metabolism (HP:0010916)2.24503294
75Hyperalaninemia (HP:0003348)2.24503294
76Furrowed tongue (HP:0000221)2.23369232
77Hepatocellular necrosis (HP:0001404)2.21981874
78Type I transferrin isoform profile (HP:0003642)2.20554329
79Acute encephalopathy (HP:0006846)2.20439589
80Reduced antithrombin III activity (HP:0001976)2.20427547
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.18925174
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.18840603
83Aplasia/Hypoplasia of the tibia (HP:0005772)2.18686086
84Ketoacidosis (HP:0001993)2.18348662
85Duodenal stenosis (HP:0100867)2.17852404
86Small intestinal stenosis (HP:0012848)2.17852404
87Irregular epiphyses (HP:0010582)2.17547701
88Fair hair (HP:0002286)2.17363806
89Congenital sensorineural hearing impairment (HP:0008527)2.16011089
90Asplenia (HP:0001746)2.15970619
91Ectopic kidney (HP:0000086)2.15900854
92Genital tract atresia (HP:0001827)2.15109029
93Epileptic encephalopathy (HP:0200134)2.13056167
94Gait imbalance (HP:0002141)2.12795346
95Recurrent abscess formation (HP:0002722)2.12465884
96Congenital primary aphakia (HP:0007707)2.12290095
97Abnormality of vitamin B metabolism (HP:0004340)2.11370238
98Chronic mucocutaneous candidiasis (HP:0002728)2.10727977
99Recurrent cutaneous fungal infections (HP:0011370)2.10727977
100Sclerocornea (HP:0000647)2.08098331
101Hepatic necrosis (HP:0002605)2.07190217
102Abnormal mitochondria in muscle tissue (HP:0008316)2.06683000
103Restrictive lung disease (HP:0002091)2.06404937
10411 pairs of ribs (HP:0000878)2.05957292
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.05233591
106Short tibia (HP:0005736)2.04813782
107IgG deficiency (HP:0004315)2.04631283
108Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04096647
109Abnormality of the duodenum (HP:0002246)2.03582310
110Tubulointerstitial nephritis (HP:0001970)2.03257747
111Postaxial foot polydactyly (HP:0001830)2.00213091
112Combined immunodeficiency (HP:0005387)1.99724704
113Abnormality of the columella (HP:0009929)1.99670602
114Congenital hepatic fibrosis (HP:0002612)1.98298150
115Irregular vertebral endplates (HP:0003301)1.97505254
116Panhypogammaglobulinemia (HP:0003139)1.96595191
117Nephrogenic diabetes insipidus (HP:0009806)1.96364990
118Aplasia/hypoplasia of the uterus (HP:0008684)1.96265525
119Vaginal atresia (HP:0000148)1.95400284
120Male pseudohermaphroditism (HP:0000037)1.95272004
121Small hand (HP:0200055)1.95180586
122Abnormality of the vertebral endplates (HP:0005106)1.93745023
123Hyperglycinemia (HP:0002154)1.93077825
124Anencephaly (HP:0002323)1.92697100
125Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91938327
126Ketosis (HP:0001946)1.91715318
127Triphalangeal thumb (HP:0001199)1.90434431
128Self-mutilation (HP:0000742)1.89152990
129Tubular atrophy (HP:0000092)1.88953717
130Follicular hyperkeratosis (HP:0007502)1.88352761
131Progressive cerebellar ataxia (HP:0002073)1.87643985
132Absent thumb (HP:0009777)1.87192374
133Abnormality of the carotid arteries (HP:0005344)1.85471331
134Generalized hypopigmentation of hair (HP:0011358)1.85227553
135Progressive inability to walk (HP:0002505)1.83800617
136Hypothermia (HP:0002045)1.83286726
137Prolonged bleeding time (HP:0003010)1.83144740
138Genetic anticipation (HP:0003743)1.82172115
139Polydipsia (HP:0001959)1.82081322
140Abnormal drinking behavior (HP:0030082)1.82081322
141Postaxial hand polydactyly (HP:0001162)1.82080187
142Intestinal atresia (HP:0011100)1.81442664
143Limb-girdle muscle atrophy (HP:0003797)1.81208429
144IgM deficiency (HP:0002850)1.81007124
145Abnormality of eosinophils (HP:0001879)1.80509260
146Optic nerve hypoplasia (HP:0000609)1.80269565
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80081289
148Large for gestational age (HP:0001520)1.79144290
149Petechiae (HP:0000967)1.79125311
150Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77066348
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.76552875
152Lymphoma (HP:0002665)1.76306367
153Bile duct proliferation (HP:0001408)1.76126609
154Abnormal biliary tract physiology (HP:0012439)1.76126609
155Lissencephaly (HP:0001339)1.75702115
156Frequent falls (HP:0002359)1.73926109
157Neutropenia (HP:0001875)1.73828769
158Pancytopenia (HP:0001876)1.73215253
159Encephalitis (HP:0002383)1.72596883
160Inability to walk (HP:0002540)1.71302916
161Abnormal number of erythroid precursors (HP:0012131)1.70912466
162Hypoplasia of the uterus (HP:0000013)1.70893662
163Abnormal spermatogenesis (HP:0008669)1.70866621
164Agammaglobulinemia (HP:0004432)1.68043499
165Bony spicule pigmentary retinopathy (HP:0007737)1.66979578
166Pallor (HP:0000980)1.66752475
167Broad-based gait (HP:0002136)1.66731552
168Dandy-Walker malformation (HP:0001305)1.66530722
169Myositis (HP:0100614)1.66523583
170Lipid accumulation in hepatocytes (HP:0006561)1.66321839
171Recurrent fungal infections (HP:0002841)1.66041750
172Absent speech (HP:0001344)1.65839091
173Stomatitis (HP:0010280)1.65825575
174Optic disc pallor (HP:0000543)1.65660080
175Hamartoma of the eye (HP:0010568)1.65423399
176Increased IgM level (HP:0003496)1.65393515
177Recurrent pneumonia (HP:0006532)1.65184445
178Thyroid-stimulating hormone excess (HP:0002925)1.64431913
179Retrobulbar optic neuritis (HP:0100654)1.64390713
180Optic neuritis (HP:0100653)1.64390713
181Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64199561
182Sloping forehead (HP:0000340)1.63981356
183Muscle fiber atrophy (HP:0100295)1.63934124
184Nephroblastoma (Wilms tumor) (HP:0002667)1.63729346
185High pitched voice (HP:0001620)1.63600151
186Preaxial hand polydactyly (HP:0001177)1.63525877
187White forelock (HP:0002211)1.62144882
188Abnormal glycosylation (HP:0012345)1.61759157

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK166.87594668
2FRK5.69784405
3CASK2.80373431
4TXK2.78817175
5WNK32.76415513
6MAP4K22.76035192
7TNIK2.74701021
8NUAK12.63167472
9SIK32.40478501
10MKNK22.32252791
11TRIM282.29529632
12MUSK2.24523615
13ZAK2.10290589
14YES12.05754247
15AKT32.04797564
16EIF2AK32.03674110
17MAP3K141.99683883
18MAP4K11.80267991
19TAF11.79798592
20MAP3K121.79304471
21FGFR21.71900430
22PRPF4B1.65218854
23MAP3K41.62400816
24EIF2AK21.61350254
25MKNK11.47531628
26INSRR1.44038342
27CAMKK21.43962850
28VRK21.42967757
29NME21.38477823
30TSSK61.36361335
31STK391.36026401
32OXSR11.34777335
33MST41.34548711
34PLK41.32999137
35ADRBK21.32699297
36TLK11.32374501
37CSNK1G31.31652625
38TEC1.30249197
39BRAF1.29677462
40CSNK1G11.29183711
41CSNK1G21.28742543
42SRPK11.28733065
43PHKG11.28536340
44PHKG21.28536340
45MAP2K71.28197603
46BCKDK1.27729669
47EPHA41.23414867
48WNK41.23071978
49BMPR21.22995833
50NLK1.22709983
51TRPM71.22168791
52BUB11.22119618
53VRK11.20195703
54PAK31.18164060
55KIT1.18117013
56CSNK1A1L1.15810178
57IKBKB1.10621228
58TIE11.09308562
59CAMK11.08880501
60SYK1.07283480
61MAP3K131.05078998
62CDK191.04966725
63LYN1.04827275
64CLK11.03822130
65NTRK31.02059971
66ERBB31.01708536
67PIM21.00877376
68BRD40.96966543
69MARK20.93202022
70DYRK20.92572489
71EIF2AK10.91000575
72DAPK10.90870062
73STK240.90125108
74IRAK40.89374351
75PRKCE0.87903609
76PLK20.86583310
77BTK0.86338560
78ZAP700.85547648
79DAPK20.83988742
80PIM10.83848800
81BCR0.82659738
82IRAK30.82084850
83SIK20.81883044
84FLT30.81549472
85ATR0.80994669
86IKBKE0.80102977
87MARK30.79858596
88FER0.76773995
89CCNB10.76661749
90CDK30.76157781
91SGK20.74020838
92PRKCG0.72601553
93MAP3K70.71175040
94NTRK20.69268356
95JAK30.69267595
96MAPKAPK30.67931233
97MAPKAPK50.67833482
98WEE10.67034441
99PLK10.66763881
100RPS6KA40.65993685
101OBSCN0.64354314
102MAPK130.63264801
103PLK30.58788277
104PTK2B0.58482611
105RIPK40.58062363
106ADRBK10.58006319
107AURKB0.55927590
108TTK0.54589009
109TNK20.54241081
110MARK10.54027944
111LCK0.52065994
112MAP2K60.50509935
113STK110.48594705
114CSNK1D0.47960252
115CSNK1A10.47862864
116CAMK2A0.47504616
117CHEK20.45964169
118RPS6KA50.45889339
119NEK20.45698790
120STK40.45557992
121PIK3CA0.44773973
122GRK50.44045873
123BMPR1B0.43507374
124NEK60.43360714
125GRK10.43325064
126CHEK10.42773378
127STK38L0.42020184
128PINK10.41767786
129PRKACA0.41729784
130CAMK40.40416531
131TGFBR10.39695716
132SGK10.38474482
133TAOK30.37910760
134KDR0.37325127
135BRSK20.36817176
136CHUK0.36669447
137ACVR1B0.36544609
138PRKAA10.35746325
139STK30.35589248
140DYRK1A0.34705692
141ATM0.34384370
142PRKCI0.34278911
143PRKCQ0.34227076
144EPHA30.32621773
145NME10.31618272
146CDC70.30759144
147PKN10.30284361
148HCK0.29792033
149CDK20.29667973
150CDK40.28963178
151GRK70.28321791
152CSF1R0.28055046
153CDK70.26774917

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030203.08728678
2Protein export_Homo sapiens_hsa030603.04335348
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.93326160
4Phototransduction_Homo sapiens_hsa047442.69426036
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.67926592
6DNA replication_Homo sapiens_hsa030302.61345724
7Nicotine addiction_Homo sapiens_hsa050332.60696810
8Fanconi anemia pathway_Homo sapiens_hsa034602.38945567
9Oxidative phosphorylation_Homo sapiens_hsa001902.23291867
10Base excision repair_Homo sapiens_hsa034102.21621209
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17079763
12Butanoate metabolism_Homo sapiens_hsa006502.15719300
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13115509
14Primary immunodeficiency_Homo sapiens_hsa053402.07218952
15* Homologous recombination_Homo sapiens_hsa034402.04824721
16Mismatch repair_Homo sapiens_hsa034302.04748703
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98960162
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.98716180
19Nitrogen metabolism_Homo sapiens_hsa009101.88919413
20Nucleotide excision repair_Homo sapiens_hsa034201.85721454
21Basal transcription factors_Homo sapiens_hsa030221.85116492
22Pyrimidine metabolism_Homo sapiens_hsa002401.84673381
23Selenocompound metabolism_Homo sapiens_hsa004501.83281131
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75828020
25Linoleic acid metabolism_Homo sapiens_hsa005911.75704958
26Non-homologous end-joining_Homo sapiens_hsa034501.69445834
27Ribosome_Homo sapiens_hsa030101.69109659
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.66388355
29Parkinsons disease_Homo sapiens_hsa050121.66284330
30Propanoate metabolism_Homo sapiens_hsa006401.64597018
31Regulation of autophagy_Homo sapiens_hsa041401.61293187
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.60034990
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59204103
34Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.53659273
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52763751
36Allograft rejection_Homo sapiens_hsa053301.52597026
37Cell cycle_Homo sapiens_hsa041101.49932254
38Tryptophan metabolism_Homo sapiens_hsa003801.47868628
39Caffeine metabolism_Homo sapiens_hsa002321.44180343
40Hematopoietic cell lineage_Homo sapiens_hsa046401.43949623
41NF-kappa B signaling pathway_Homo sapiens_hsa040641.42841733
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42480795
43Proteasome_Homo sapiens_hsa030501.39486540
44Purine metabolism_Homo sapiens_hsa002301.38042079
45Spliceosome_Homo sapiens_hsa030401.35355146
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32930428
47Autoimmune thyroid disease_Homo sapiens_hsa053201.32347458
48Peroxisome_Homo sapiens_hsa041461.29763989
49RNA degradation_Homo sapiens_hsa030181.26743388
50Sulfur metabolism_Homo sapiens_hsa009201.26292194
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.23678619
52Chemical carcinogenesis_Homo sapiens_hsa052041.20819987
53Glutamatergic synapse_Homo sapiens_hsa047241.19509002
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.19374574
55RNA transport_Homo sapiens_hsa030131.16938792
56Herpes simplex infection_Homo sapiens_hsa051681.16397405
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13420713
58Insulin secretion_Homo sapiens_hsa049111.13344591
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.12428619
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12004019
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.11505895
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07784179
63Vibrio cholerae infection_Homo sapiens_hsa051101.07483344
64Sphingolipid metabolism_Homo sapiens_hsa006001.06460637
65Retinol metabolism_Homo sapiens_hsa008301.06296363
66Huntingtons disease_Homo sapiens_hsa050161.02816486
67Measles_Homo sapiens_hsa051621.00644176
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.99772055
69Alzheimers disease_Homo sapiens_hsa050100.99398831
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.97480076
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.96630284
72Rheumatoid arthritis_Homo sapiens_hsa053230.94753698
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93624332
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92950258
75Type I diabetes mellitus_Homo sapiens_hsa049400.91227943
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91062187
77p53 signaling pathway_Homo sapiens_hsa041150.90664340
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89679044
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.88446864
80Long-term potentiation_Homo sapiens_hsa047200.88242811
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86471896
82Circadian entrainment_Homo sapiens_hsa047130.85829275
83Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84486809
84Long-term depression_Homo sapiens_hsa047300.83162806
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80553312
86Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.80029668
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79780266
88Graft-versus-host disease_Homo sapiens_hsa053320.79514976
89Morphine addiction_Homo sapiens_hsa050320.79043332
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75753903
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74957276
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74292133
93ABC transporters_Homo sapiens_hsa020100.74022886
94Cardiac muscle contraction_Homo sapiens_hsa042600.73856350
95Asthma_Homo sapiens_hsa053100.73169578
96Amphetamine addiction_Homo sapiens_hsa050310.70823719
97Metabolic pathways_Homo sapiens_hsa011000.70395747
98One carbon pool by folate_Homo sapiens_hsa006700.69455853
99Arachidonic acid metabolism_Homo sapiens_hsa005900.67688344
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67480036
101Epstein-Barr virus infection_Homo sapiens_hsa051690.67067879
102Vitamin B6 metabolism_Homo sapiens_hsa007500.64896125
103Fatty acid elongation_Homo sapiens_hsa000620.63605571
104Collecting duct acid secretion_Homo sapiens_hsa049660.63539578
105Calcium signaling pathway_Homo sapiens_hsa040200.62936625
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62851303
107Hedgehog signaling pathway_Homo sapiens_hsa043400.62690089
108Leishmaniasis_Homo sapiens_hsa051400.62154486
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.62147386
110Synaptic vesicle cycle_Homo sapiens_hsa047210.60978704
111Cocaine addiction_Homo sapiens_hsa050300.58444335
112Phagosome_Homo sapiens_hsa041450.58301544
113Taste transduction_Homo sapiens_hsa047420.57930464
114Malaria_Homo sapiens_hsa051440.56999063
115Serotonergic synapse_Homo sapiens_hsa047260.56848201
116Vitamin digestion and absorption_Homo sapiens_hsa049770.55795075
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55693166
118African trypanosomiasis_Homo sapiens_hsa051430.55654670
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55136452
120beta-Alanine metabolism_Homo sapiens_hsa004100.54848420
121Glycerolipid metabolism_Homo sapiens_hsa005610.54804642
122GABAergic synapse_Homo sapiens_hsa047270.53439958
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53359722
124mRNA surveillance pathway_Homo sapiens_hsa030150.52453773
125Steroid biosynthesis_Homo sapiens_hsa001000.48681653
126Influenza A_Homo sapiens_hsa051640.48676350
127Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48172823
128Circadian rhythm_Homo sapiens_hsa047100.47977005
129Dorso-ventral axis formation_Homo sapiens_hsa043200.47854099
130Fatty acid metabolism_Homo sapiens_hsa012120.47142275
131Fatty acid degradation_Homo sapiens_hsa000710.46731510
132Salivary secretion_Homo sapiens_hsa049700.46698701
133T cell receptor signaling pathway_Homo sapiens_hsa046600.46520552
134Glutathione metabolism_Homo sapiens_hsa004800.42847359
135Systemic lupus erythematosus_Homo sapiens_hsa053220.41412592
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41039166
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40839677
138Legionellosis_Homo sapiens_hsa051340.40741670
139Mineral absorption_Homo sapiens_hsa049780.40534928
140HTLV-I infection_Homo sapiens_hsa051660.40471497
141MicroRNAs in cancer_Homo sapiens_hsa052060.39598782
142Ovarian steroidogenesis_Homo sapiens_hsa049130.38334619
143Fat digestion and absorption_Homo sapiens_hsa049750.36896132
144Ether lipid metabolism_Homo sapiens_hsa005650.35867293
145Oocyte meiosis_Homo sapiens_hsa041140.35669157
146Hepatitis B_Homo sapiens_hsa051610.35580821
147Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33680378
148Tuberculosis_Homo sapiens_hsa051520.32359030
149Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32041014
150Olfactory transduction_Homo sapiens_hsa047400.31306716
151Apoptosis_Homo sapiens_hsa042100.28958815
152Thyroid cancer_Homo sapiens_hsa052160.28866718

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