RAD51D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, which are known to be involved in the homologous recombination and repair of DNA. This protein forms a complex with several other members of the RAD51 family, including RAD51L1, RAD51L2, and XRCC2. The protein complex formed with this protein has been shown to catalyze homologous pairing between single- and double-stranded DNA, and is thought to play a role in the early stage of recombinational repair of DNA. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream ring finger and FYVE-like domain containing 1 (RFFL) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.19878784
2DNA deamination (GO:0045006)5.50734385
3behavioral response to nicotine (GO:0035095)5.32024522
4response to pheromone (GO:0019236)5.14527493
5viral transcription (GO:0019083)5.01503006
6L-fucose catabolic process (GO:0042355)4.90210840
7fucose catabolic process (GO:0019317)4.90210840
8L-fucose metabolic process (GO:0042354)4.90210840
9translational termination (GO:0006415)4.89766632
10translational elongation (GO:0006414)4.35988352
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.29187440
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.29187440
13ribosomal small subunit biogenesis (GO:0042274)4.21568691
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.18618895
15maturation of SSU-rRNA (GO:0030490)4.13927419
16cotranslational protein targeting to membrane (GO:0006613)4.09652434
17protein targeting to ER (GO:0045047)4.07794289
18indolalkylamine metabolic process (GO:0006586)4.01876672
19tryptophan catabolic process (GO:0006569)4.01075774
20indole-containing compound catabolic process (GO:0042436)4.01075774
21indolalkylamine catabolic process (GO:0046218)4.01075774
22cellular ketone body metabolic process (GO:0046950)3.90276653
23protein localization to endoplasmic reticulum (GO:0070972)3.90259406
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.90188627
25DNA strand elongation involved in DNA replication (GO:0006271)3.88125514
26translational initiation (GO:0006413)3.86512860
27detection of light stimulus involved in visual perception (GO:0050908)3.86117612
28detection of light stimulus involved in sensory perception (GO:0050962)3.86117612
29kynurenine metabolic process (GO:0070189)3.84123115
30antigen processing and presentation of endogenous antigen (GO:0019883)3.83793057
31nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.83313687
32detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.82755053
33DNA strand elongation (GO:0022616)3.81060365
34telomere maintenance via semi-conservative replication (GO:0032201)3.76466026
35cellular protein complex disassembly (GO:0043624)3.75342263
36viral life cycle (GO:0019058)3.72694690
37negative regulation of telomere maintenance (GO:0032205)3.55381772
38DNA unwinding involved in DNA replication (GO:0006268)3.54923639
39tryptophan metabolic process (GO:0006568)3.51678502
40ketone body metabolic process (GO:1902224)3.50116864
41replication fork processing (GO:0031297)3.42012863
42ribosomal large subunit biogenesis (GO:0042273)3.37760621
43DNA replication initiation (GO:0006270)3.35312131
44antigen processing and presentation via MHC class Ib (GO:0002475)3.35095538
45protein complex disassembly (GO:0043241)3.30504106
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.27310031
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27107814
48regulation of nuclear cell cycle DNA replication (GO:0033262)3.24051715
49meiotic chromosome segregation (GO:0045132)3.23742996
50telomere maintenance via recombination (GO:0000722)3.23365861
51L-methionine salvage (GO:0071267)3.22684128
52L-methionine biosynthetic process (GO:0071265)3.22684128
53amino acid salvage (GO:0043102)3.22684128
54regulation of hippo signaling (GO:0035330)3.21524829
55antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21415747
56preassembly of GPI anchor in ER membrane (GO:0016254)3.21303339
57formation of translation preinitiation complex (GO:0001731)3.16240887
58proteasome assembly (GO:0043248)3.14059911
59macromolecular complex disassembly (GO:0032984)3.13069330
60neural tube formation (GO:0001841)3.11971053
61water-soluble vitamin biosynthetic process (GO:0042364)3.07341992
62piRNA metabolic process (GO:0034587)3.06269266
63rRNA catabolic process (GO:0016075)3.04468215
64* recombinational repair (GO:0000725)3.04363487
65nuclear-transcribed mRNA catabolic process (GO:0000956)3.04041365
66* double-strand break repair via homologous recombination (GO:0000724)3.03675377
67translation (GO:0006412)3.03316078
68ribonucleoprotein complex biogenesis (GO:0022613)3.03284415
69platelet dense granule organization (GO:0060155)3.02402309
70cellular response to ATP (GO:0071318)2.99220576
71ncRNA 3-end processing (GO:0043628)2.97566302
72indole-containing compound metabolic process (GO:0042430)2.97416906
73positive regulation of developmental pigmentation (GO:0048087)2.97282461
74mannosylation (GO:0097502)2.96777652
75peptidyl-histidine modification (GO:0018202)2.96413237
76signal peptide processing (GO:0006465)2.94949271
77cornea development in camera-type eye (GO:0061303)2.94902930
78fucosylation (GO:0036065)2.92059022
79mRNA catabolic process (GO:0006402)2.90451468
80centriole replication (GO:0007099)2.89577685
81pseudouridine synthesis (GO:0001522)2.89287230
82nephron tubule morphogenesis (GO:0072078)2.88509656
83nephron epithelium morphogenesis (GO:0072088)2.88509656
84epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.87407469
85telomere maintenance via telomere lengthening (GO:0010833)2.85365877
86positive regulation of B cell differentiation (GO:0045579)2.80876213
87photoreceptor cell development (GO:0042461)2.79751520
88DNA double-strand break processing (GO:0000729)2.79415697
89RNA catabolic process (GO:0006401)2.78895149
90mitotic recombination (GO:0006312)2.78866795
91gamma-aminobutyric acid transport (GO:0015812)2.77852057
92photoreceptor cell maintenance (GO:0045494)2.77822546
93pentose-phosphate shunt (GO:0006098)2.77268007
94negative regulation of DNA-dependent DNA replication (GO:2000104)2.77175780
95protein targeting to membrane (GO:0006612)2.77048853
96L-serine metabolic process (GO:0006563)2.76089165
97negative regulation of mast cell activation (GO:0033004)2.75610127
98protein K11-linked deubiquitination (GO:0035871)2.75498912
99RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.74876001
100* reciprocal DNA recombination (GO:0035825)2.73887370
101* reciprocal meiotic recombination (GO:0007131)2.73887370
102respiratory chain complex IV assembly (GO:0008535)2.72814002
103negative regulation of translation, ncRNA-mediated (GO:0040033)2.71490821
104regulation of translation, ncRNA-mediated (GO:0045974)2.71490821
105negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.71490821
106cilium or flagellum-dependent cell motility (GO:0001539)2.70477675
107pteridine-containing compound biosynthetic process (GO:0042559)2.68370758
108protein-cofactor linkage (GO:0018065)2.67833280
109sulfation (GO:0051923)2.67517785
110behavioral response to ethanol (GO:0048149)2.67128094
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66616666
112mitochondrial respiratory chain complex I assembly (GO:0032981)2.66616666
113NADH dehydrogenase complex assembly (GO:0010257)2.66616666
114nucleobase biosynthetic process (GO:0046112)2.66198188
115axoneme assembly (GO:0035082)2.66190080
116NAD biosynthetic process (GO:0009435)2.66110140
117regulation of rhodopsin mediated signaling pathway (GO:0022400)2.66011110
118protein polyglutamylation (GO:0018095)2.64820549
119spinal cord motor neuron differentiation (GO:0021522)2.64635714
120folic acid-containing compound biosynthetic process (GO:0009396)2.62999461
121rhodopsin mediated signaling pathway (GO:0016056)2.62634166
122Arp2/3 complex-mediated actin nucleation (GO:0034314)2.62264154
123cellular biogenic amine catabolic process (GO:0042402)2.62203480
124amine catabolic process (GO:0009310)2.62203480
125DNA methylation involved in gamete generation (GO:0043046)2.61713576
126negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.61691025
127DNA demethylation (GO:0080111)2.61468967
128positive regulation of defense response to virus by host (GO:0002230)2.61127117
129rRNA processing (GO:0006364)2.59982975
130cytochrome complex assembly (GO:0017004)2.59963151
131protein complex biogenesis (GO:0070271)2.58701252
132positive regulation of gamma-delta T cell activation (GO:0046645)2.58611086
133neuronal action potential (GO:0019228)2.57666650
134cilium morphogenesis (GO:0060271)2.57639210
135mitochondrial DNA replication (GO:0006264)2.57227305
136nonmotile primary cilium assembly (GO:0035058)2.57147728
137regulation of action potential (GO:0098900)2.56344275
138regulation of telomere maintenance (GO:0032204)2.56270070
139methionine biosynthetic process (GO:0009086)2.55355791
140antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.55154192
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55068863
142ribosome biogenesis (GO:0042254)2.54900230
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.54255090
144reflex (GO:0060004)2.54090491
145primary amino compound metabolic process (GO:1901160)2.53669077
146epithelial cilium movement (GO:0003351)2.53447615
147eye photoreceptor cell development (GO:0042462)2.53155187
148tRNA modification (GO:0006400)2.52139422
149purine nucleobase biosynthetic process (GO:0009113)2.50004779
150auditory receptor cell stereocilium organization (GO:0060088)2.49461939
151necroptotic process (GO:0070266)2.48420761
152cAMP catabolic process (GO:0006198)2.48307439
153oxidative demethylation (GO:0070989)2.48202779
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.48081025
155multicellular organism reproduction (GO:0032504)2.47926080
156serine family amino acid biosynthetic process (GO:0009070)2.47908638
157mitochondrial respiratory chain complex assembly (GO:0033108)2.47693804
158rRNA metabolic process (GO:0016072)2.47542301
159DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.46520350
160cilium organization (GO:0044782)2.46392440
161aspartate family amino acid biosynthetic process (GO:0009067)2.46056247
162protein K6-linked ubiquitination (GO:0085020)2.45851447
163negative regulation of reactive oxygen species metabolic process (GO:2000378)2.45706933
164purine-containing compound salvage (GO:0043101)2.45514155
165NADPH regeneration (GO:0006740)2.44782343
166valine metabolic process (GO:0006573)2.44542180
167regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.44465720
168signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.43766357
169intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.43766357
170cellular response to exogenous dsRNA (GO:0071360)2.43148862
171anterograde synaptic vesicle transport (GO:0048490)2.41464308
172antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.40768955
173negative regulation of ligase activity (GO:0051352)2.40352949
174negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.40352949
175NIK/NF-kappaB signaling (GO:0038061)2.39538504
176somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.39152605
177somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.39152605
178isotype switching (GO:0045190)2.39152605
179cellular component biogenesis (GO:0044085)2.37952016
180signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.37586096
181signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.37586096
182signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.37586096
183cellular metabolic compound salvage (GO:0043094)2.36676954
184regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.36570222
185negative regulation of phagocytosis (GO:0050765)2.35649836
186glycine metabolic process (GO:0006544)2.35530214
187sulfur amino acid biosynthetic process (GO:0000097)2.35296777
188B cell mediated immunity (GO:0019724)2.34121319
189regulation of B cell differentiation (GO:0045577)2.34058809
190folic acid metabolic process (GO:0046655)2.33541789
191positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.32670509
192purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.32335599
193nucleoside salvage (GO:0043174)2.31627931
194nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.31610379
195positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.31542643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.36925226
2ZNF274_21170338_ChIP-Seq_K562_Hela4.13448884
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65493659
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.33946988
5VDR_22108803_ChIP-Seq_LS180_Human3.28084239
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.04788224
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85641521
8GBX2_23144817_ChIP-Seq_PC3_Human2.75145920
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.72740856
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.58799596
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56293322
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.54076899
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46018313
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.37087935
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36233131
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.35207264
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33670552
18EWS_26573619_Chip-Seq_HEK293_Human2.33400999
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.30825541
20IGF1R_20145208_ChIP-Seq_DFB_Human2.29048527
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29025286
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.27353715
23EZH2_22144423_ChIP-Seq_EOC_Human2.24122217
24SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.23635857
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.19878770
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.18806530
27SALL1_21062744_ChIP-ChIP_HESCs_Human2.18300250
28VDR_23849224_ChIP-Seq_CD4+_Human2.15764382
29FUS_26573619_Chip-Seq_HEK293_Human2.15151474
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.13565079
31CREB1_15753290_ChIP-ChIP_HEK293T_Human2.13434315
32CTBP2_25329375_ChIP-Seq_LNCAP_Human2.12952053
33IRF8_22096565_ChIP-ChIP_GC-B_Human2.12003212
34MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11517747
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.10205897
36POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06851546
37MYC_22102868_ChIP-Seq_BL_Human2.05597520
38FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.03142547
39FOXP3_21729870_ChIP-Seq_TREG_Human2.01871700
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01520790
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.97965874
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.96369783
43ER_23166858_ChIP-Seq_MCF-7_Human1.94288961
44XRN2_22483619_ChIP-Seq_HELA_Human1.92159191
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90971628
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89435057
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.88784769
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.88135991
49GATA1_22025678_ChIP-Seq_K562_Human1.82676856
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.82439804
51IRF1_19129219_ChIP-ChIP_H3396_Human1.81396566
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80334529
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79018238
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76755750
55DCP1A_22483619_ChIP-Seq_HELA_Human1.76040299
56P300_19829295_ChIP-Seq_ESCs_Human1.75372969
57TAF15_26573619_Chip-Seq_HEK293_Human1.75181465
58GABP_19822575_ChIP-Seq_HepG2_Human1.73882584
59HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73717693
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73689683
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.70789214
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70616044
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68128295
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.67925383
65VDR_21846776_ChIP-Seq_THP-1_Human1.66759415
66TP53_22573176_ChIP-Seq_HFKS_Human1.66258111
67MYC_18940864_ChIP-ChIP_HL60_Human1.63180539
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.62004784
69AR_21572438_ChIP-Seq_LNCaP_Human1.61109626
70CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59855352
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58854486
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57959445
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.57916199
74MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57692053
75THAP11_20581084_ChIP-Seq_MESCs_Mouse1.57514343
76STAT3_23295773_ChIP-Seq_U87_Human1.57358374
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55059380
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54139894
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53984983
80ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.53919263
81MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53081017
82SPI1_23547873_ChIP-Seq_NB4_Human1.52569123
83BCAT_22108803_ChIP-Seq_LS180_Human1.51812206
84SCL_19346495_ChIP-Seq_HPC-7_Human1.51798976
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51641923
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.50752147
87CIITA_25753668_ChIP-Seq_RAJI_Human1.50510206
88AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50395208
89CBP_20019798_ChIP-Seq_JUKART_Human1.48176441
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48176441
91EGR1_19374776_ChIP-ChIP_THP-1_Human1.45044416
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44338547
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41850487
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41614244
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41614244
96TCF4_23295773_ChIP-Seq_U87_Human1.40974385
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39419586
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35976985
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34822324
100FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31165650
101FOXA1_25329375_ChIP-Seq_VCAP_Human1.31165650
102AR_25329375_ChIP-Seq_VCAP_Human1.31138143
103IRF8_21731497_ChIP-ChIP_J774_Mouse1.30786067
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30328504
105MAF_26560356_Chip-Seq_TH1_Human1.30307399
106KDM5A_27292631_Chip-Seq_BREAST_Human1.29988472
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28938519
108YY1_21170310_ChIP-Seq_MESCs_Mouse1.28900160
109TTF2_22483619_ChIP-Seq_HELA_Human1.28536452
110SMAD4_21799915_ChIP-Seq_A2780_Human1.28278397
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27255535
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26042849
113MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25937459
114RUNX1_22412390_ChIP-Seq_EML_Mouse1.25709801
115GATA3_21878914_ChIP-Seq_MCF-7_Human1.25214051
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24463523
117HOXB7_26014856_ChIP-Seq_BT474_Human1.24422111
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.23824134
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23245593
120EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22687489
121PIAS1_25552417_ChIP-Seq_VCAP_Human1.22531496
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22458378
123NANOG_19829295_ChIP-Seq_ESCs_Human1.22025987
124SOX2_19829295_ChIP-Seq_ESCs_Human1.22025987
125CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21859438
126CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20812576
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20641917
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19691403
129NCOR_22424771_ChIP-Seq_293T_Human1.19601535
130UTX_26944678_Chip-Seq_JUKART_Human1.19549305
131MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.19502376
132MYB_26560356_Chip-Seq_TH2_Human1.19362464
133FOXM1_23109430_ChIP-Seq_U2OS_Human1.19113123
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.18826513
135AR_21909140_ChIP-Seq_LNCAP_Human1.17359733
136STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17345344
137TCF4_22108803_ChIP-Seq_LS180_Human1.17246207
138MYB_26560356_Chip-Seq_TH1_Human1.16646930
139REST_21632747_ChIP-Seq_MESCs_Mouse1.16541658
140TFEB_21752829_ChIP-Seq_HELA_Human1.16116749
141AR_20517297_ChIP-Seq_VCAP_Human1.15717172
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15625821
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15331871
144VDR_24763502_ChIP-Seq_THP-1_Human1.13091840
145KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12826613
146NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12259049
147MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11973575
148FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11917849
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10660819
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.10169897
151KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10154406
152SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10142567
153PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09852996
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.09356815
155NFE2_27457419_Chip-Seq_LIVER_Mouse1.09212421
156RUNX2_22187159_ChIP-Seq_PCA_Human1.08811662
157STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08724425
158ERA_21632823_ChIP-Seq_H3396_Human1.08703458
159FLI1_21867929_ChIP-Seq_TH2_Mouse1.07582489
160BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06828245
161GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06410110
162TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05952285
163CBX2_27304074_Chip-Seq_ESCs_Mouse1.05735710
164MAF_26560356_Chip-Seq_TH2_Human1.05404907
165EZH2_27294783_Chip-Seq_NPCs_Mouse1.04777686
166ELK1_19687146_ChIP-ChIP_HELA_Human1.03255126
167SMAD3_21741376_ChIP-Seq_EPCs_Human1.02469949
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02229634
169SMAD4_21741376_ChIP-Seq_EPCs_Human1.01918212
170BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01723714
171PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01278237
172EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01044182
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.00655107
174E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00594408
175GATA3_26560356_Chip-Seq_TH2_Human1.00311475
176MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00006216
177E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99702161
178TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99516279
179BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.98664670
180NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98142738
181MYC_19829295_ChIP-Seq_ESCs_Human0.96915836
182NANOG_20526341_ChIP-Seq_ESCs_Human0.94659275
183TAF2_19829295_ChIP-Seq_ESCs_Human0.93395861
184TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93357007
185HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92957538
186P53_21459846_ChIP-Seq_SAOS-2_Human0.92371589
187CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.91747256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation2.98652003
2MP0000685_abnormal_immune_system2.94809267
3MP0002396_abnormal_hematopoietic_system2.94034897
4MP0003806_abnormal_nucleotide_metabolis2.84192787
5MP0000569_abnormal_digit_pigmentation2.80336971
6MP0003136_yellow_coat_color2.75833576
7MP0001835_abnormal_antigen_presentation2.75780356
8MP0003693_abnormal_embryo_hatching2.65132780
9MP0003195_calcinosis2.59965732
10MP0003763_abnormal_thymus_physiology2.57451930
11MP0005551_abnormal_eye_electrophysiolog2.50124038
12MP0001986_abnormal_taste_sensitivity2.49952564
13MP0001968_abnormal_touch/_nociception2.46921558
14MP0005671_abnormal_response_to2.37068518
15MP0002102_abnormal_ear_morphology2.28617354
16MP0004957_abnormal_blastocyst_morpholog2.24436959
17MP0010094_abnormal_chromosome_stability2.23346572
18MP0009333_abnormal_splenocyte_physiolog2.13457819
19MP0001853_heart_inflammation2.11488993
20MP0003646_muscle_fatigue2.09619765
21MP0002166_altered_tumor_susceptibility2.07715908
22MP0002398_abnormal_bone_marrow2.06759214
23MP0001800_abnormal_humoral_immune2.04700174
24MP0009840_abnormal_foam_cell2.03714880
25MP0005645_abnormal_hypothalamus_physiol2.01361713
26MP0009785_altered_susceptibility_to1.99171521
27MP0000372_irregular_coat_pigmentation1.96062918
28MP0001545_abnormal_hematopoietic_system1.95788906
29MP0005397_hematopoietic_system_phenotyp1.95788906
30MP0005025_abnormal_response_to1.95591503
31MP0004043_abnormal_pH_regulation1.95372340
32MP0002638_abnormal_pupillary_reflex1.94747325
33MP0005075_abnormal_melanosome_morpholog1.93791859
34MP0002837_dystrophic_cardiac_calcinosis1.93593825
35MP0003436_decreased_susceptibility_to1.93031246
36MP0003724_increased_susceptibility_to1.89166852
37MP0000689_abnormal_spleen_morphology1.88788417
38MP0002139_abnormal_hepatobiliary_system1.88210706
39MP0002736_abnormal_nociception_after1.86192225
40MP0002723_abnormal_immune_serum1.83410930
41MP0000427_abnormal_hair_cycle1.83073239
42MP0002420_abnormal_adaptive_immunity1.82622085
43MP0008872_abnormal_physiological_respon1.81845244
44MP0003077_abnormal_cell_cycle1.81438286
45MP0009046_muscle_twitch1.81263223
46MP0005387_immune_system_phenotype1.80640311
47MP0001790_abnormal_immune_system1.80640311
48MP0003186_abnormal_redox_activity1.79487429
49MP0001819_abnormal_immune_cell1.78176468
50MP0006072_abnormal_retinal_apoptosis1.77048840
51MP0005464_abnormal_platelet_physiology1.75435758
52MP0000716_abnormal_immune_system1.75402001
53MP0005000_abnormal_immune_tolerance1.74601373
54MP0002722_abnormal_immune_system1.73561613
55MP0002452_abnormal_antigen_presenting1.71409539
56MP0001485_abnormal_pinna_reflex1.66737931
57MP0010352_gastrointestinal_tract_polyps1.66541891
58MP0002429_abnormal_blood_cell1.65512602
59MP0006036_abnormal_mitochondrial_physio1.64052711
60MP0009745_abnormal_behavioral_response1.61559251
61MP0005253_abnormal_eye_physiology1.61547665
62MP0002876_abnormal_thyroid_physiology1.61008772
63MP0005646_abnormal_pituitary_gland1.59361729
64MP0005365_abnormal_bile_salt1.58721809
65MP0003866_abnormal_defecation1.58388269
66MP0003787_abnormal_imprinting1.58044677
67MP0004808_abnormal_hematopoietic_stem1.57819046
68MP0004142_abnormal_muscle_tone1.57002479
69MP0002006_tumorigenesis1.53921943
70MP0008007_abnormal_cellular_replicative1.51140327
71MP0000490_abnormal_crypts_of1.50396589
72MP0003191_abnormal_cellular_cholesterol1.49972071
73MP0001501_abnormal_sleep_pattern1.49795885
74MP0005058_abnormal_lysosome_morphology1.48637816
75MP0003111_abnormal_nucleus_morphology1.48325066
76MP0010155_abnormal_intestine_physiology1.47829344
77MP0002405_respiratory_system_inflammati1.46453987
78MP0000703_abnormal_thymus_morphology1.45523845
79MP0000015_abnormal_ear_pigmentation1.44942252
80MP0000383_abnormal_hair_follicle1.41781893
81MP0003656_abnormal_erythrocyte_physiolo1.40483192
82MP0005171_absent_coat_pigmentation1.40058798
83MP0006292_abnormal_olfactory_placode1.39880425
84MP0002019_abnormal_tumor_incidence1.39141706
85MP0005174_abnormal_tail_pigmentation1.39017864
86MP0002419_abnormal_innate_immunity1.39003030
87MP0002148_abnormal_hypersensitivity_rea1.38999169
88MP0000465_gastrointestinal_hemorrhage1.38513909
89MP0008058_abnormal_DNA_repair1.37675010
90MP0002735_abnormal_chemical_nociception1.37078401
91MP0005084_abnormal_gallbladder_morpholo1.35403477
92MP0005377_hearing/vestibular/ear_phenot1.34143665
93MP0003878_abnormal_ear_physiology1.34143665
94MP0001873_stomach_inflammation1.34012084
95MP0000631_abnormal_neuroendocrine_gland1.31117919
96MP0002160_abnormal_reproductive_system1.30812207
97MP0000858_altered_metastatic_potential1.29519340
98MP0004133_heterotaxia1.28580138
99MP0002938_white_spotting1.28015942
100MP0002928_abnormal_bile_duct1.26859116
101MP0002272_abnormal_nervous_system1.26140209
102MP0008469_abnormal_protein_level1.25621095
103MP0001845_abnormal_inflammatory_respons1.25288546
104MP0006035_abnormal_mitochondrial_morpho1.24415563
105MP0009379_abnormal_foot_pigmentation1.24330600
106MP0005584_abnormal_enzyme/coenzyme_acti1.24184910
107MP0008875_abnormal_xenobiotic_pharmacok1.24133617
108MP0006276_abnormal_autonomic_nervous1.22866779
109MP0005389_reproductive_system_phenotype1.20665291
110MP0001764_abnormal_homeostasis1.20377799
111MP0008057_abnormal_DNA_replication1.20298792
112MP0000609_abnormal_liver_physiology1.14541379
113MP0010386_abnormal_urinary_bladder1.14207591
114MP0001666_abnormal_nutrient_absorption1.13598089
115MP0002733_abnormal_thermal_nociception1.13542181
116MP0004147_increased_porphyrin_level1.13209691
117MP0002572_abnormal_emotion/affect_behav1.13128961
118MP0005670_abnormal_white_adipose1.13061166
119MP0005360_urolithiasis1.13016410
120MP0004885_abnormal_endolymph1.12579325
121MP0002653_abnormal_ependyma_morphology1.11764251
122MP0004742_abnormal_vestibular_system1.11667185
123MP0003221_abnormal_cardiomyocyte_apopto1.10942713
124MP0005410_abnormal_fertilization1.07499199
125MP0003011_delayed_dark_adaptation1.06192478
126MP0001970_abnormal_pain_threshold1.05940324
127MP0000313_abnormal_cell_death1.05557358
128MP0001486_abnormal_startle_reflex1.04797437
129MP0002163_abnormal_gland_morphology1.04244480
130MP0002234_abnormal_pharynx_morphology1.03682379
131MP0002064_seizures1.03208790
132MP0003786_premature_aging1.02991834
133MP0003283_abnormal_digestive_organ1.01647054
134MP0002557_abnormal_social/conspecific_i1.00860126
135MP0002095_abnormal_skin_pigmentation1.00840077
136MP0005379_endocrine/exocrine_gland_phen1.00541739
137MP0001919_abnormal_reproductive_system0.99866037
138MP0000598_abnormal_liver_morphology0.99111882
139MP0004947_skin_inflammation0.98808340
140MP0005319_abnormal_enzyme/_coenzyme0.98394414
141MP0002210_abnormal_sex_determination0.97163359
142MP0005195_abnormal_posterior_eye0.96887353
143MP0002067_abnormal_sensory_capabilities0.96589120
144MP0008873_increased_physiological_sensi0.96102672
145MP0009763_increased_sensitivity_to0.95589246
146MP0003698_abnormal_male_reproductive0.95087536
147MP0008995_early_reproductive_senescence0.93681830
148MP0001929_abnormal_gametogenesis0.92643022
149MP0000358_abnormal_cell_content/0.92329260
150MP0004924_abnormal_behavior0.91240219
151MP0005386_behavior/neurological_phenoty0.91240219
152MP0010329_abnormal_lipoprotein_level0.91216396
153MP0001730_embryonic_growth_arrest0.90967623
154MP0008260_abnormal_autophagy0.89597710
155MP0003880_abnormal_central_pattern0.88981205
156MP0003252_abnormal_bile_duct0.88375240
157MP0002693_abnormal_pancreas_physiology0.87841379
158MP0000350_abnormal_cell_proliferation0.87342527
159MP0008932_abnormal_embryonic_tissue0.84790120
160MP0001324_abnormal_eye_pigmentation0.84103246
161MP0002751_abnormal_autonomic_nervous0.83880738
162MP0004130_abnormal_muscle_cell0.83680232
163MP0002933_joint_inflammation0.83677274
164MP0001905_abnormal_dopamine_level0.82759527
165MP0009765_abnormal_xenobiotic_induced0.82641291
166MP0005332_abnormal_amino_acid0.82121636
167MP0006082_CNS_inflammation0.82095761
168MP0008961_abnormal_basal_metabolism0.81525570
169MP0000538_abnormal_urinary_bladder0.80589377
170MP0003718_maternal_effect0.80237329
171MP0002009_preneoplasia0.79815442
172MP0000230_abnormal_systemic_arterial0.79676310
173MP0002970_abnormal_white_adipose0.79513129
174MP0002132_abnormal_respiratory_system0.78441125
175MP0000653_abnormal_sex_gland0.77534492
176MP0005085_abnormal_gallbladder_physiolo0.77468350
177MP0002063_abnormal_learning/memory/cond0.77455844
178MP0008775_abnormal_heart_ventricle0.76637745
179MP0000371_diluted_coat_color0.75525673
180MP0002752_abnormal_somatic_nervous0.75007630
181MP0001145_abnormal_male_reproductive0.74827738
182MP0000026_abnormal_inner_ear0.73475360
183MP0002138_abnormal_hepatobiliary_system0.72519214
184MP0001963_abnormal_hearing_physiology0.72132589
185MP0003635_abnormal_synaptic_transmissio0.71881659
186MP0002080_prenatal_lethality0.70754423
187MP0003172_abnormal_lysosome_physiology0.70169195
188MP0001533_abnormal_skeleton_physiology0.69662067

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.96133504
2Pancreatic cysts (HP:0001737)4.51664827
3Thrombocytosis (HP:0001894)4.48123714
4Abnormality of cells of the erythroid lineage (HP:0012130)4.47600522
5Congenital stationary night blindness (HP:0007642)4.34644075
6Abnormal number of erythroid precursors (HP:0012131)4.24613524
7Aplastic anemia (HP:0001915)4.24280872
8Abnormality of midbrain morphology (HP:0002418)4.05420781
9Molar tooth sign on MRI (HP:0002419)4.05420781
10Reticulocytopenia (HP:0001896)3.87064236
11Pancreatic fibrosis (HP:0100732)3.85796673
12True hermaphroditism (HP:0010459)3.74783859
13Elevated erythrocyte sedimentation rate (HP:0003565)3.67810301
14Nephronophthisis (HP:0000090)3.59943866
15Abnormality of T cell physiology (HP:0011840)3.57887726
16Attenuation of retinal blood vessels (HP:0007843)3.53544711
17IgM deficiency (HP:0002850)3.40225085
18Panhypogammaglobulinemia (HP:0003139)3.30545257
19Abnormality of T cells (HP:0002843)3.22014008
20Abnormality of the renal medulla (HP:0100957)3.20185944
21Type II lissencephaly (HP:0007260)3.17269068
22Hyperventilation (HP:0002883)3.12343778
23Abnormality of the renal cortex (HP:0011035)3.11980749
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11331757
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11331757
26Hepatic necrosis (HP:0002605)2.99125600
27Hepatocellular necrosis (HP:0001404)2.95496533
28Macrocytic anemia (HP:0001972)2.90129019
29Recurrent viral infections (HP:0004429)2.87756476
30Tubular atrophy (HP:0000092)2.82978934
31Cystic liver disease (HP:0006706)2.77748050
32Abolished electroretinogram (ERG) (HP:0000550)2.76666112
33Recurrent bronchitis (HP:0002837)2.76175992
34Genetic anticipation (HP:0003743)2.75869240
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.75243717
36Chronic hepatic failure (HP:0100626)2.73532668
37Pancytopenia (HP:0001876)2.70055910
38Birth length less than 3rd percentile (HP:0003561)2.68199456
39Gaze-evoked nystagmus (HP:0000640)2.67054439
40Patellar aplasia (HP:0006443)2.66942471
41Pallor (HP:0000980)2.65566491
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63397880
43Medial flaring of the eyebrow (HP:0010747)2.60995895
44Large for gestational age (HP:0001520)2.59906934
45Oral leukoplakia (HP:0002745)2.59452183
46Bony spicule pigmentary retinopathy (HP:0007737)2.59322135
47Abnormal drinking behavior (HP:0030082)2.56127411
48Polydipsia (HP:0001959)2.56127411
49Inability to walk (HP:0002540)2.56054353
50Abnormal rod and cone electroretinograms (HP:0008323)2.55598974
51Aplasia/Hypoplasia of the patella (HP:0006498)2.55247771
52Progressive inability to walk (HP:0002505)2.50848646
53Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.49541013
54Progressive cerebellar ataxia (HP:0002073)2.49222510
55Multiple enchondromatosis (HP:0005701)2.49153678
56Cerebellar dysplasia (HP:0007033)2.48019997
57Aplasia/Hypoplasia of the uvula (HP:0010293)2.46641863
58Colon cancer (HP:0003003)2.45037931
59T lymphocytopenia (HP:0005403)2.44872706
60Pendular nystagmus (HP:0012043)2.42917266
61Abnormality of the pons (HP:0007361)2.41995964
62Nasal polyposis (HP:0100582)2.41158031
63IgG deficiency (HP:0004315)2.40353887
64Abnormality of T cell number (HP:0011839)2.35200961
65Sclerocornea (HP:0000647)2.34606192
66Hypoplasia of the thymus (HP:0000778)2.34505669
67Lissencephaly (HP:0001339)2.34392116
68Hypoplasia of the pons (HP:0012110)2.34069983
69Ragged-red muscle fibers (HP:0003200)2.33311460
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.32965047
71Dicarboxylic aciduria (HP:0003215)2.32965047
72Abnormality of fatty-acid metabolism (HP:0004359)2.31555215
73Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30229761
74Generalized aminoaciduria (HP:0002909)2.27480873
75Congenital hepatic fibrosis (HP:0002612)2.27015643
76Recurrent fungal infections (HP:0002841)2.25508005
77B lymphocytopenia (HP:0010976)2.22688485
78Abnormality of B cell number (HP:0010975)2.22688485
79Lymphoma (HP:0002665)2.22228739
80Abnormality of the nasal mucosa (HP:0000433)2.21760929
81Increased muscle lipid content (HP:0009058)2.20063143
82Protruding tongue (HP:0010808)2.19749795
83Increased serum lactate (HP:0002151)2.19562928
84Abnormality of the heme biosynthetic pathway (HP:0010472)2.18805819
85Neutropenia (HP:0001875)2.18441250
86Chorioretinal atrophy (HP:0000533)2.18077610
873-Methylglutaconic aciduria (HP:0003535)2.16444759
88Spastic diplegia (HP:0001264)2.13832847
89Bile duct proliferation (HP:0001408)2.13473496
90Abnormal biliary tract physiology (HP:0012439)2.13473496
91Clubbing of toes (HP:0100760)2.13074422
92Combined immunodeficiency (HP:0005387)2.12019070
93Myositis (HP:0100614)2.11708466
94Furrowed tongue (HP:0000221)2.11362686
95Keratoconus (HP:0000563)2.10594951
96Increased corneal curvature (HP:0100692)2.10594951
97Myelodysplasia (HP:0002863)2.10096106
98Renal cortical cysts (HP:0000803)2.09476286
99Poor head control (HP:0002421)2.09235640
100Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08363177
101Abnormality of the ileum (HP:0001549)2.07860984
102Prolonged bleeding time (HP:0003010)2.06649682
103Decreased circulating renin level (HP:0003351)2.05625966
104Aplasia/Hypoplasia of the sacrum (HP:0008517)2.05546973
105Increased serum pyruvate (HP:0003542)2.05091019
106Abnormality of glycolysis (HP:0004366)2.05091019
107Severe combined immunodeficiency (HP:0004430)2.04775916
108Aplasia/Hypoplasia of the tibia (HP:0005772)2.04396806
109Duplicated collecting system (HP:0000081)2.03626553
110Reduced antithrombin III activity (HP:0001976)2.03355272
111Gastrointestinal inflammation (HP:0004386)2.03329127
112Meckel diverticulum (HP:0002245)2.02595972
113Agammaglobulinemia (HP:0004432)2.02324717
114Stomach cancer (HP:0012126)2.02276076
115Petechiae (HP:0000967)2.02113057
116Abnormality of macrophages (HP:0004311)2.02099056
117Cerebral hypomyelination (HP:0006808)2.01947279
118Abnormality of the renal collecting system (HP:0004742)2.01690668
119Decreased central vision (HP:0007663)2.01513438
120Congenital, generalized hypertrichosis (HP:0004540)2.01192719
121Poikiloderma (HP:0001029)2.00830779
122Polyuria (HP:0000103)2.00813172
123Clumsiness (HP:0002312)2.00582508
124Lymphopenia (HP:0001888)2.00502697
125Recurrent bacterial skin infections (HP:0005406)2.00395575
126Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00275638
127Progressive muscle weakness (HP:0003323)1.99501694
128Cellular immunodeficiency (HP:0005374)1.98105305
129Microretrognathia (HP:0000308)1.97914771
130Aplasia/Hypoplasia of the tongue (HP:0010295)1.97891410
131Impaired platelet aggregation (HP:0003540)1.97802516
132Abnormal platelet function (HP:0011869)1.97802516
133Hyperammonemia (HP:0001987)1.96777602
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.95682464
135Absent speech (HP:0001344)1.95334240
136Broad-based gait (HP:0002136)1.95323061
137Brushfield spots (HP:0001088)1.94499773
138Sloping forehead (HP:0000340)1.92467563
139Chromsome breakage (HP:0040012)1.92322037
140Rough bone trabeculation (HP:0100670)1.91528461
141Anencephaly (HP:0002323)1.91269122
142Inflammation of the large intestine (HP:0002037)1.90541615
143Fatigue (HP:0012378)1.89682927
144Gait imbalance (HP:0002141)1.89533938
145Hypertriglyceridemia (HP:0002155)1.89325921
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89123470
147Abnormality of alanine metabolism (HP:0010916)1.89123470
148Hyperalaninemia (HP:0003348)1.89123470
149Lactic acidosis (HP:0003128)1.88145980
150Epistaxis (HP:0000421)1.87961162
151Congenital primary aphakia (HP:0007707)1.87916405
152IgA deficiency (HP:0002720)1.87672255
153Small hand (HP:0200055)1.87537654
154Chronic mucocutaneous candidiasis (HP:0002728)1.87103483
155Recurrent cutaneous fungal infections (HP:0011370)1.87103483
156Microcytic anemia (HP:0001935)1.86860577
157Retinal dysplasia (HP:0007973)1.86754112
158Fair hair (HP:0002286)1.86308728
159Recurrent abscess formation (HP:0002722)1.86221783
160Gastrointestinal stroma tumor (HP:0100723)1.86100943
161Abnormality of DNA repair (HP:0003254)1.85437894
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.84376369
163Dynein arm defect of respiratory motile cilia (HP:0012255)1.83921913
164Absent/shortened dynein arms (HP:0200106)1.83921913
165Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.83232110
166Postaxial foot polydactyly (HP:0001830)1.81880104
167Absent thumb (HP:0009777)1.81507195
168Granulocytopenia (HP:0001913)1.81141222
169Severe muscular hypotonia (HP:0006829)1.81024824
170Constricted visual fields (HP:0001133)1.80803320
171Recurrent skin infections (HP:0001581)1.79909631
172Increased CSF lactate (HP:0002490)1.79699437
173Hyperlipoproteinemia (HP:0010980)1.78865701
174Increased intramyocellular lipid droplets (HP:0012240)1.78276891
175Pustule (HP:0200039)1.77669671
176Type I transferrin isoform profile (HP:0003642)1.77598837
177Abnormality of chromosome stability (HP:0003220)1.76973082
178Male pseudohermaphroditism (HP:0000037)1.76692329
179Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76375105
180Nephrogenic diabetes insipidus (HP:0009806)1.76325172
181Abnormality of methionine metabolism (HP:0010901)1.75935260
182Hypoalbuminemia (HP:0003073)1.75374541
183Abnormal albumin level (HP:0012116)1.75374541
184Hepatosplenomegaly (HP:0001433)1.75310379
185Optic nerve hypoplasia (HP:0000609)1.75195317
186Methylmalonic aciduria (HP:0012120)1.74880731
187Premature graying of hair (HP:0002216)1.74281487
188Febrile seizures (HP:0002373)1.72872839
189Astigmatism (HP:0000483)1.72020083
190Hypothermia (HP:0002045)1.70237656
191Ketosis (HP:0001946)1.69517623
192Widely spaced teeth (HP:0000687)1.69427211
193Optic disc pallor (HP:0000543)1.69315423
194Dandy-Walker malformation (HP:0001305)1.69005679

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.59955469
2BMPR1B3.79520813
3MAP4K13.74106480
4ZAK3.21523493
5ADRBK23.15332164
6WEE13.01077349
7NME22.90361529
8MAP4K22.86873748
9NUAK12.79999645
10BCKDK2.61564901
11STK162.61144807
12FLT32.58942688
13TESK22.57745776
14WNK42.53638005
15MAP2K32.51887958
16BUB12.40281056
17EEF2K2.27961031
18SCYL22.25871612
19GRK12.23795783
20WNK32.15786566
21KIT2.11837304
22ZAP702.08543453
23TAOK32.07557704
24EIF2AK12.06118645
25BTK1.95149634
26INSRR1.84315505
27CCNB11.81540391
28MAPK131.78585388
29CDK191.76093343
30PIM21.70194930
31EIF2AK31.66999580
32RAF11.66851720
33MAP3K111.65322530
34STK391.62333128
35TEC1.60321118
36TYK21.58326287
37BLK1.53831160
38VRK11.50346258
39OXSR11.48369627
40PINK11.47530074
41LRRK21.45017614
42BRSK21.42675156
43CASK1.41299179
44TXK1.41089639
45RPS6KB21.41068983
46DAPK21.40843235
47MAP3K41.37536404
48CSF1R1.37320941
49MAPKAPK31.36286564
50VRK21.33814192
51KDR1.31790298
52ERN11.31547740
53TGFBR11.31312245
54STK101.31163482
55MAPKAPK51.27930324
56MKNK21.26310107
57ADRBK11.22783356
58TBK11.22385844
59JAK31.19984100
60ITK1.18955967
61TAF11.17739230
62DYRK31.16438497
63IKBKB1.14649688
64KSR21.13565701
65TRIB31.10985542
66PNCK1.10594339
67CDK71.10499919
68ACVR1B1.10310933
69GRK61.09500338
70SYK1.07820853
71TAOK11.04416673
72NEK21.02829144
73CDC71.00498072
74MAP3K100.98379564
75MAPK150.95633624
76LCK0.94555864
77IKBKE0.93876032
78PLK40.93026808
79NEK10.92012079
80PKN20.91775231
81MAP3K60.90886935
82MAP3K130.88611577
83PASK0.88263004
84MAP3K80.86484244
85IRAK40.84585233
86DYRK20.80423563
87CAMKK20.79047839
88TSSK60.77802991
89NLK0.76410152
90MAP2K70.75237642
91TLK10.75156214
92CDK40.74793826
93PRKCQ0.74013553
94TRIM280.73195771
95PAK30.72478463
96CHEK20.71899930
97PIM10.71716981
98TNIK0.70896455
99ARAF0.70795953
100PRKCE0.69328470
101TGFBR20.69189190
102PRKCG0.68657038
103LYN0.68003375
104CSNK1G30.67999898
105TNK20.67651364
106PTK2B0.66143235
107NTRK30.65086595
108MELK0.64852956
109STK110.64136553
110MAP3K120.64108353
111MUSK0.62193098
112PIK3CG0.61765298
113ATR0.61644826
114STK38L0.60645541
115MAPK110.59008738
116FGFR40.57640238
117ILK0.57445963
118MARK10.57027443
119CDK80.56815950
120TRPM70.56754630
121MKNK10.54887871
122AURKB0.54850011
123PKN10.54042783
124JAK20.53006627
125PAK40.52266243
126HCK0.51117844
127CSNK1G10.51088847
128DAPK10.49760988
129STK30.49162700
130MAP2K60.48944287
131AKT30.47269123
132CSNK1A1L0.45864938
133MAPK40.45711316
134BRSK10.44139284
135SRPK10.44045080
136MAP3K70.43866971
137MAP3K30.42650534
138CHUK0.40800287
139SIK20.40600870
140MAP2K20.40500120
141PIK3CA0.40373394
142PLK30.40165267
143YES10.39548869
144PLK10.39292451
145PRKAA20.39191330
146CSNK1G20.38844918
147CSNK1D0.38485244
148TIE10.38369650
149PRKCI0.38230314
150MATK0.38116372
151MST40.37766596
152CAMK10.37441281
153ATM0.37023249
154NTRK20.36820224
155TESK10.36358609
156FGFR20.36290358
157NME10.35288611
158RPS6KA40.34457043
159PLK20.34008429
160EPHB10.33876560
161MOS0.33831854
162PRKAA10.33553216
163PHKG20.33236739
164PHKG10.33236739
165MYLK0.31206938
166RPS6KA50.29908586
167RET0.29011886
168MAPKAPK20.28886823
169PAK10.28657629

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.32427907
2DNA replication_Homo sapiens_hsa030304.31250017
3Mismatch repair_Homo sapiens_hsa034303.12473875
4Proteasome_Homo sapiens_hsa030502.90206613
5Phototransduction_Homo sapiens_hsa047442.70379283
6Base excision repair_Homo sapiens_hsa034102.61538051
7Butanoate metabolism_Homo sapiens_hsa006502.61234220
8Nitrogen metabolism_Homo sapiens_hsa009102.53396967
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.52180773
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50465376
11Primary immunodeficiency_Homo sapiens_hsa053402.29983613
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23213197
13Linoleic acid metabolism_Homo sapiens_hsa005912.18819700
14Folate biosynthesis_Homo sapiens_hsa007902.12134163
15Cyanoamino acid metabolism_Homo sapiens_hsa004602.11502966
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04041638
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01992388
18Pyrimidine metabolism_Homo sapiens_hsa002401.94735219
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94086068
20Nucleotide excision repair_Homo sapiens_hsa034201.92784942
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92651825
22RNA polymerase_Homo sapiens_hsa030201.87688123
23Pentose phosphate pathway_Homo sapiens_hsa000301.85621441
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.83766658
25* Homologous recombination_Homo sapiens_hsa034401.75796463
26Nicotine addiction_Homo sapiens_hsa050331.70173083
27Tryptophan metabolism_Homo sapiens_hsa003801.66305384
28Spliceosome_Homo sapiens_hsa030401.65997196
29One carbon pool by folate_Homo sapiens_hsa006701.65935171
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65420910
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.55855162
32Biosynthesis of amino acids_Homo sapiens_hsa012301.46802151
33RNA transport_Homo sapiens_hsa030131.45858805
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45098255
35Ether lipid metabolism_Homo sapiens_hsa005651.41867323
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37833228
37Taste transduction_Homo sapiens_hsa047421.36868886
38ABC transporters_Homo sapiens_hsa020101.35199587
39Olfactory transduction_Homo sapiens_hsa047401.34411829
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31691848
41Oxidative phosphorylation_Homo sapiens_hsa001901.28565338
42RNA degradation_Homo sapiens_hsa030181.24118969
43Sulfur relay system_Homo sapiens_hsa041221.23503785
44Cell cycle_Homo sapiens_hsa041101.23344704
45Morphine addiction_Homo sapiens_hsa050321.21662197
46Antigen processing and presentation_Homo sapiens_hsa046121.18644959
47Fatty acid degradation_Homo sapiens_hsa000711.17495227
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17238923
49Non-homologous end-joining_Homo sapiens_hsa034501.16557281
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14005926
51Carbon metabolism_Homo sapiens_hsa012001.13818875
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12968271
53Caffeine metabolism_Homo sapiens_hsa002321.12404218
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11690986
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.11529037
56Drug metabolism - other enzymes_Homo sapiens_hsa009831.06314116
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.03120545
58Herpes simplex infection_Homo sapiens_hsa051681.02974125
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02043483
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.00429439
61Selenocompound metabolism_Homo sapiens_hsa004501.00289483
62Shigellosis_Homo sapiens_hsa051310.99659350
63Allograft rejection_Homo sapiens_hsa053300.97964766
64B cell receptor signaling pathway_Homo sapiens_hsa046620.97453334
65Peroxisome_Homo sapiens_hsa041460.96198218
66Propanoate metabolism_Homo sapiens_hsa006400.94854153
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93826252
68Measles_Homo sapiens_hsa051620.93790767
69Basal transcription factors_Homo sapiens_hsa030220.86663376
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86587447
71Epstein-Barr virus infection_Homo sapiens_hsa051690.86147811
72Pyruvate metabolism_Homo sapiens_hsa006200.82252040
73Chemical carcinogenesis_Homo sapiens_hsa052040.81928080
74Purine metabolism_Homo sapiens_hsa002300.81322695
75Circadian entrainment_Homo sapiens_hsa047130.81254510
76Fatty acid elongation_Homo sapiens_hsa000620.80978092
77Fanconi anemia pathway_Homo sapiens_hsa034600.78951726
78Asthma_Homo sapiens_hsa053100.78845170
79Protein export_Homo sapiens_hsa030600.78609904
80T cell receptor signaling pathway_Homo sapiens_hsa046600.78308993
81p53 signaling pathway_Homo sapiens_hsa041150.78164974
82Serotonergic synapse_Homo sapiens_hsa047260.77351832
83Regulation of autophagy_Homo sapiens_hsa041400.76887696
84Huntingtons disease_Homo sapiens_hsa050160.76779304
85Arachidonic acid metabolism_Homo sapiens_hsa005900.76720472
86Insulin secretion_Homo sapiens_hsa049110.76691290
87Fatty acid metabolism_Homo sapiens_hsa012120.76639027
88Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.76375365
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.75203594
90Leishmaniasis_Homo sapiens_hsa051400.74431721
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71843039
92Acute myeloid leukemia_Homo sapiens_hsa052210.70584063
93Ovarian steroidogenesis_Homo sapiens_hsa049130.69702901
94Calcium signaling pathway_Homo sapiens_hsa040200.68790153
95Lysine degradation_Homo sapiens_hsa003100.67933001
96Glutamatergic synapse_Homo sapiens_hsa047240.67602737
97GABAergic synapse_Homo sapiens_hsa047270.67028280
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66947991
99Legionellosis_Homo sapiens_hsa051340.66776618
100Glycerolipid metabolism_Homo sapiens_hsa005610.66694000
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66324253
102Retinol metabolism_Homo sapiens_hsa008300.65412615
103Vitamin B6 metabolism_Homo sapiens_hsa007500.64666902
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64535620
105Dorso-ventral axis formation_Homo sapiens_hsa043200.64443875
106Glutathione metabolism_Homo sapiens_hsa004800.64187093
107Salivary secretion_Homo sapiens_hsa049700.63310693
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58510684
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58193446
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57706607
111Thyroid cancer_Homo sapiens_hsa052160.57105907
112Graft-versus-host disease_Homo sapiens_hsa053320.56644732
113Parkinsons disease_Homo sapiens_hsa050120.56125365
114Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55961924
115Apoptosis_Homo sapiens_hsa042100.53473758
116Type I diabetes mellitus_Homo sapiens_hsa049400.52480676
117N-Glycan biosynthesis_Homo sapiens_hsa005100.51323931
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51089612
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49558462
120Hepatitis B_Homo sapiens_hsa051610.47788011
121Alzheimers disease_Homo sapiens_hsa050100.46422114
122Fatty acid biosynthesis_Homo sapiens_hsa000610.46044816
123Viral carcinogenesis_Homo sapiens_hsa052030.45627777
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.45226976
125Influenza A_Homo sapiens_hsa051640.44904587
126Metabolic pathways_Homo sapiens_hsa011000.44759835
127Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44729676
128Autoimmune thyroid disease_Homo sapiens_hsa053200.43861771
129Hematopoietic cell lineage_Homo sapiens_hsa046400.43381877
130Vitamin digestion and absorption_Homo sapiens_hsa049770.41972025
131Cardiac muscle contraction_Homo sapiens_hsa042600.41778917
132Viral myocarditis_Homo sapiens_hsa054160.41430714
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41294523
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41141893
135Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40212989
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39954981
137Fructose and mannose metabolism_Homo sapiens_hsa000510.39434337
138Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39104496
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.39035624
140Hedgehog signaling pathway_Homo sapiens_hsa043400.38336563
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37784460
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37315443
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37292679
144NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36042213
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.35897736
146Toxoplasmosis_Homo sapiens_hsa051450.35784763
147Osteoclast differentiation_Homo sapiens_hsa043800.35590063
148beta-Alanine metabolism_Homo sapiens_hsa004100.33202036
149PPAR signaling pathway_Homo sapiens_hsa033200.33143455
150Pertussis_Homo sapiens_hsa051330.31217168
151Cholinergic synapse_Homo sapiens_hsa047250.31172727
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.30611209
153Long-term depression_Homo sapiens_hsa047300.30338400
154Histidine metabolism_Homo sapiens_hsa003400.29562541

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