RAD50

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.14956544
2nuclear pore organization (GO:0006999)4.90549453
3mitotic sister chromatid cohesion (GO:0007064)4.74764640
4DNA unwinding involved in DNA replication (GO:0006268)4.65067318
5kinetochore organization (GO:0051383)4.56166613
6protein localization to kinetochore (GO:0034501)4.41677804
7DNA strand elongation involved in DNA replication (GO:0006271)4.34183905
8mitotic chromosome condensation (GO:0007076)4.31104479
9telomere maintenance via semi-conservative replication (GO:0032201)4.19406601
10DNA replication initiation (GO:0006270)4.17544027
11mitotic recombination (GO:0006312)4.15481884
12ribosomal small subunit assembly (GO:0000028)4.14563634
13DNA strand elongation (GO:0022616)4.14051247
14chromatin remodeling at centromere (GO:0031055)4.12376001
15mitotic metaphase plate congression (GO:0007080)4.11395581
16telomere maintenance via recombination (GO:0000722)4.10543215
17CENP-A containing nucleosome assembly (GO:0034080)4.09399896
18DNA replication checkpoint (GO:0000076)4.06640927
19mitotic nuclear envelope disassembly (GO:0007077)4.04570407
20pore complex assembly (GO:0046931)4.02303125
21metaphase plate congression (GO:0051310)3.98060991
22meiotic chromosome segregation (GO:0045132)3.84972402
23protein localization to chromosome, centromeric region (GO:0071459)3.82090716
24centriole replication (GO:0007099)3.78212903
25mitotic sister chromatid segregation (GO:0000070)3.77140939
26attachment of spindle microtubules to kinetochore (GO:0008608)3.75950386
27membrane disassembly (GO:0030397)3.74411008
28nuclear envelope disassembly (GO:0051081)3.74411008
29sister chromatid segregation (GO:0000819)3.74249407
30DNA replication-independent nucleosome organization (GO:0034724)3.74099167
31DNA replication-independent nucleosome assembly (GO:0006336)3.74099167
32kinetochore assembly (GO:0051382)3.72033910
33regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.71411700
34regulation of spindle organization (GO:0090224)3.69685989
35establishment of chromosome localization (GO:0051303)3.63481188
36regulation of mitotic spindle organization (GO:0060236)3.51730606
37regulation of histone H3-K9 methylation (GO:0051570)3.45895776
38positive regulation of histone H3-K4 methylation (GO:0051571)3.44210892
39nucleotide-excision repair, DNA gap filling (GO:0006297)3.43634046
40* telomere maintenance via telomere lengthening (GO:0010833)3.41736599
41regulation of helicase activity (GO:0051095)3.40826978
42regulation of translational fidelity (GO:0006450)3.40007942
43IMP biosynthetic process (GO:0006188)3.39925431
44histone exchange (GO:0043486)3.38467795
45regulation of RNA export from nucleus (GO:0046831)3.37608499
46replication fork processing (GO:0031297)3.34993896
47regulation of DNA endoreduplication (GO:0032875)3.32739467
48positive regulation of chromosome segregation (GO:0051984)3.31792745
49* DNA geometric change (GO:0032392)3.30619636
50* DNA duplex unwinding (GO:0032508)3.30564045
51maturation of SSU-rRNA (GO:0030490)3.29199785
52DNA double-strand break processing (GO:0000729)3.28492490
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.25332911
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.25332911
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.25332911
56chromatin assembly or disassembly (GO:0006333)3.21752103
57DNA replication-dependent nucleosome assembly (GO:0006335)3.21335008
58DNA replication-dependent nucleosome organization (GO:0034723)3.21335008
59IMP metabolic process (GO:0046040)3.20621653
60DNA topological change (GO:0006265)3.17517018
61regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17428379
62regulation of centrosome duplication (GO:0010824)3.14495387
63negative regulation of histone methylation (GO:0031061)3.14168599
64double-strand break repair via nonhomologous end joining (GO:0006303)3.13597192
65non-recombinational repair (GO:0000726)3.13597192
66viral transcription (GO:0019083)3.13558042
67translational termination (GO:0006415)3.12124285
68* telomere maintenance (GO:0000723)3.11997532
69nucleobase biosynthetic process (GO:0046112)3.10469032
70spindle checkpoint (GO:0031577)3.10096485
71* telomere organization (GO:0032200)3.08803711
72regulation of centriole replication (GO:0046599)3.08288051
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06903656
74folic acid-containing compound biosynthetic process (GO:0009396)3.05077371
75negative regulation of DNA-dependent DNA replication (GO:2000104)3.04988141
76regulation of sister chromatid cohesion (GO:0007063)3.03979080
77maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03664164
78synapsis (GO:0007129)3.03155488
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.03111793
80intra-S DNA damage checkpoint (GO:0031573)3.01973534
81sister chromatid cohesion (GO:0007062)2.99633607
82chromosome segregation (GO:0007059)2.99534018
83amino acid activation (GO:0043038)2.99074531
84tRNA aminoacylation (GO:0043039)2.99074531
85tRNA aminoacylation for protein translation (GO:0006418)2.98998022
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.98911461
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98911461
88protein localization to chromosome (GO:0034502)2.98575505
89centriole assembly (GO:0098534)2.98118593
90spindle assembly checkpoint (GO:0071173)2.97915038
91regulation of mitotic spindle checkpoint (GO:1903504)2.96951551
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.96951551
93regulation of chromosome segregation (GO:0051983)2.96883163
94ATP-dependent chromatin remodeling (GO:0043044)2.96795579
95* DNA conformation change (GO:0071103)2.96047453
96protein K6-linked ubiquitination (GO:0085020)2.94839268
97formation of translation preinitiation complex (GO:0001731)2.93761276
98translesion synthesis (GO:0019985)2.92091239
99regulation of centrosome cycle (GO:0046605)2.90635391
100ribosomal large subunit biogenesis (GO:0042273)2.90343785
101negative regulation of chromosome segregation (GO:0051985)2.90196879
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.89774467
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89774467
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89774467
105negative regulation of sister chromatid segregation (GO:0033046)2.89774467
106DNA synthesis involved in DNA repair (GO:0000731)2.89137974
107* telomere maintenance via telomerase (GO:0007004)2.87598948
108mitotic spindle assembly checkpoint (GO:0007094)2.87176641
109mitotic spindle checkpoint (GO:0071174)2.87131170
110regulation of sister chromatid segregation (GO:0033045)2.86463167
111regulation of mitotic sister chromatid separation (GO:0010965)2.86463167
112regulation of mitotic sister chromatid segregation (GO:0033047)2.86463167
113regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.85880091
114negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.85371151
115nuclear envelope organization (GO:0006998)2.84945314
116mismatch repair (GO:0006298)2.84943429
117purine nucleobase biosynthetic process (GO:0009113)2.83488391
118dosage compensation (GO:0007549)2.81491512
119regulation of nuclear cell cycle DNA replication (GO:0033262)2.79854219
120resolution of meiotic recombination intermediates (GO:0000712)2.79249376
121regulation of mitochondrial translation (GO:0070129)2.77395790
122response to X-ray (GO:0010165)2.75610497
123regulation of DNA-dependent DNA replication (GO:0090329)2.75391032
124positive regulation of histone methylation (GO:0031062)2.64335400
125centrosome duplication (GO:0051298)2.61339055
126mitotic G2/M transition checkpoint (GO:0044818)2.61077858
127DNA-dependent DNA replication (GO:0006261)2.60074773
128chromosome organization involved in meiosis (GO:0070192)2.59934605
129negative regulation of DNA recombination (GO:0045910)2.59865186
130ribosome biogenesis (GO:0042254)2.59774624
131mRNA cleavage (GO:0006379)2.59521949
132regulation of histone H3-K4 methylation (GO:0051569)2.59053078
133regulation of meiosis I (GO:0060631)2.57754688
134nucleotide-excision repair, DNA damage removal (GO:0000718)2.57115083
135DNA excision (GO:0044349)2.57115083
136negative regulation of DNA repair (GO:0045738)2.56919052
137postreplication repair (GO:0006301)2.56215370
138monoubiquitinated protein deubiquitination (GO:0035520)2.54861391
139centrosome organization (GO:0051297)2.53201910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.00881090
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.45552547
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.58511265
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.56276016
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.14935277
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74398386
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.69984375
8AR_21909140_ChIP-Seq_LNCAP_Human2.52530723
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46433361
10* E2F1_21310950_ChIP-Seq_MCF-7_Human2.45428434
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.34237324
12FUS_26573619_Chip-Seq_HEK293_Human2.29302881
13* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.23065013
14* EST1_17652178_ChIP-ChIP_JURKAT_Human2.22223912
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.17290542
16* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10119266
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.01598750
18E2F7_22180533_ChIP-Seq_HELA_Human11.1762655
19EWS_26573619_Chip-Seq_HEK293_Human1.98194195
20VDR_23849224_ChIP-Seq_CD4+_Human1.93199385
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.91915414
22XRN2_22483619_ChIP-Seq_HELA_Human1.89913902
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85853528
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.85343450
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84654334
26RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84485078
27ELK1_19687146_ChIP-ChIP_HELA_Human1.83068239
28MYC_22102868_ChIP-Seq_BL_Human1.82952924
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82250727
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79710426
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.78256975
32FOXP3_21729870_ChIP-Seq_TREG_Human1.75393232
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73306379
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71121042
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66216892
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.63572948
37CIITA_25753668_ChIP-Seq_RAJI_Human1.60090116
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59736726
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.59110716
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58546679
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58357084
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56762285
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.54754513
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.52393015
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51635442
46TTF2_22483619_ChIP-Seq_HELA_Human1.51580373
47DCP1A_22483619_ChIP-Seq_HELA_Human1.51562295
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50988976
49HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48134168
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47091447
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.36071986
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.36033187
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35947542
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33187906
55KDM5A_27292631_Chip-Seq_BREAST_Human1.33062361
56* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.31429106
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.31196264
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30533727
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29222724
60FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28759810
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.27677157
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27200866
63GABP_19822575_ChIP-Seq_HepG2_Human1.27122611
64* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25595409
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24039361
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24023533
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23709653
68TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.22239215
69TAF15_26573619_Chip-Seq_HEK293_Human1.21414894
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21067371
71IGF1R_20145208_ChIP-Seq_DFB_Human1.20401816
72SPI1_23547873_ChIP-Seq_NB4_Human1.19677954
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19527605
74VDR_21846776_ChIP-Seq_THP-1_Human1.18707161
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17316959
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15915701
77SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15408638
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14576162
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14260566
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13760420
81VDR_22108803_ChIP-Seq_LS180_Human1.12502957
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12191810
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10546805
84* TFEB_21752829_ChIP-Seq_HELA_Human1.10071826
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09733167
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09485937
87MYB_26560356_Chip-Seq_TH2_Human1.09426413
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08948278
89ZNF274_21170338_ChIP-Seq_K562_Hela1.07936719
90MYB_26560356_Chip-Seq_TH1_Human1.05587408
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.02306910
92FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02100135
93CBP_20019798_ChIP-Seq_JUKART_Human1.01835398
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01835398
95IRF8_22096565_ChIP-ChIP_GC-B_Human1.01664271
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00133121
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.99316913
98MYC_18940864_ChIP-ChIP_HL60_Human0.99097426
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98584673
100STAT3_23295773_ChIP-Seq_U87_Human0.98242186
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97427886
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.96438650
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.95459988
104STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95001708
105SCL_19346495_ChIP-Seq_HPC-7_Human0.94832162
106* TCF4_23295773_ChIP-Seq_U87_Human0.94692989
107CHD1_26751641_Chip-Seq_LNCaP_Human0.94604717
108STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94476724
109ER_23166858_ChIP-Seq_MCF-7_Human0.93059896
110ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92741720
111GBX2_23144817_ChIP-Seq_PC3_Human0.92044098
112PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90922967
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89913917
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88874086
115PIAS1_25552417_ChIP-Seq_VCAP_Human0.88276947
116P300_19829295_ChIP-Seq_ESCs_Human0.88175316
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87849550
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.87718955
119CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87067212
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86698687
121SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86524112
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.85983521
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.85585588
124STAT4_19710469_ChIP-ChIP_TH1__Mouse0.85525672
125SOX17_20123909_ChIP-Seq_XEN_Mouse0.82902553
126RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82585369
127UTX_26944678_Chip-Seq_JUKART_Human0.82541603
128KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82127506
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81963161
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.81864010
131PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81694768
132MAF_26560356_Chip-Seq_TH1_Human0.81680272
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81479338
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.80841580
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80284090
136SMAD4_21799915_ChIP-Seq_A2780_Human0.80050217
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.78600544
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.78345720
139* ELF5_23300383_ChIP-Seq_T47D_Human0.77383891
140IRF8_21731497_ChIP-ChIP_J774_Mouse0.76807900
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.76795047
142TOP2B_26459242_ChIP-Seq_MCF-7_Human0.75940710
143NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.75367663
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.75158963

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.57994990
2MP0003693_abnormal_embryo_hatching4.37649942
3MP0008057_abnormal_DNA_replication3.90126157
4MP0003111_abnormal_nucleus_morphology3.63969507
5MP0003077_abnormal_cell_cycle3.56006350
6MP0004957_abnormal_blastocyst_morpholog3.39937628
7* MP0002396_abnormal_hematopoietic_system3.05084630
8MP0008058_abnormal_DNA_repair2.94569638
9MP0010352_gastrointestinal_tract_polyps2.75710315
10MP0008007_abnormal_cellular_replicative2.63003204
11MP0006292_abnormal_olfactory_placode2.53713570
12MP0010307_abnormal_tumor_latency2.20946443
13MP0004808_abnormal_hematopoietic_stem2.11741249
14* MP0000350_abnormal_cell_proliferation1.98938977
15MP0008932_abnormal_embryonic_tissue1.96725109
16* MP0001730_embryonic_growth_arrest1.89726384
17MP0000490_abnormal_crypts_of1.87807009
18MP0009780_abnormal_chondrocyte_physiolo1.83238925
19MP0003763_abnormal_thymus_physiology1.81182275
20* MP0008877_abnormal_DNA_methylation1.78680325
21MP0009697_abnormal_copulation1.78302370
22MP0002166_altered_tumor_susceptibility1.68379493
23MP0003941_abnormal_skin_development1.65438024
24MP0005076_abnormal_cell_differentiation1.63761062
25MP0002006_tumorigenesis1.59698349
26MP0003786_premature_aging1.58442600
27MP0000566_synostosis1.56914463
28MP0000427_abnormal_hair_cycle1.51884814
29MP0001835_abnormal_antigen_presentation1.51159764
30* MP0002019_abnormal_tumor_incidence1.49187867
31MP0001672_abnormal_embryogenesis/_devel1.45563868
32MP0005380_embryogenesis_phenotype1.45563868
33* MP0002398_abnormal_bone_marrow1.45108494
34MP0003123_paternal_imprinting1.44822910
35* MP0005397_hematopoietic_system_phenotyp1.42700409
36* MP0001545_abnormal_hematopoietic_system1.42700409
37* MP0001697_abnormal_embryo_size1.42412095
38MP0000579_abnormal_nail_morphology1.40024822
39MP0003984_embryonic_growth_retardation1.38250456
40* MP0000703_abnormal_thymus_morphology1.35937080
41MP0002234_abnormal_pharynx_morphology1.35043016
42MP0002088_abnormal_embryonic_growth/wei1.34035550
43MP0004043_abnormal_pH_regulation1.33901454
44MP0001661_extended_life_span1.31074084
45* MP0000313_abnormal_cell_death1.30977899
46MP0002086_abnormal_extraembryonic_tissu1.30890944
47MP0002938_white_spotting1.27635393
48MP0003567_abnormal_fetal_cardiomyocyte1.27403502
49MP0002877_abnormal_melanocyte_morpholog1.26340840
50* MP0002722_abnormal_immune_system1.25524668
51MP0002160_abnormal_reproductive_system1.24913113
52MP0008789_abnormal_olfactory_epithelium1.23960258
53* MP0002080_prenatal_lethality1.21000909
54MP0003121_genomic_imprinting1.20728429
55* MP0002084_abnormal_developmental_patter1.20035610
56MP0002085_abnormal_embryonic_tissue1.18582623
57* MP0000689_abnormal_spleen_morphology1.18253618
58MP0004197_abnormal_fetal_growth/weight/1.18117236
59MP0001873_stomach_inflammation1.16856442
60MP0009333_abnormal_splenocyte_physiolog1.16444933
61MP0010678_abnormal_skin_adnexa1.16402532
62* MP0001800_abnormal_humoral_immune1.15952676
63MP0005408_hypopigmentation1.14001835
64MP0000569_abnormal_digit_pigmentation1.11012897
65MP0006072_abnormal_retinal_apoptosis1.10927271
66* MP0002429_abnormal_blood_cell1.07581782
67MP0002009_preneoplasia1.07353266
68MP0005394_taste/olfaction_phenotype1.06476721
69MP0005499_abnormal_olfactory_system1.06476721
70* MP0000716_abnormal_immune_system1.06470480
71MP0006054_spinal_hemorrhage1.05691345
72MP0000428_abnormal_craniofacial_morphol1.05157789
73MP0005671_abnormal_response_to1.03585944
74* MP0002452_abnormal_antigen_presenting1.03443027
75MP0002210_abnormal_sex_determination1.03334319
76MP0000685_abnormal_immune_system1.02863077
77MP0000858_altered_metastatic_potential1.01689740
78* MP0002420_abnormal_adaptive_immunity1.01645909
79MP0003566_abnormal_cell_adhesion1.01165264
80MP0005023_abnormal_wound_healing0.99540097
81* MP0001819_abnormal_immune_cell0.99445088
82MP0002405_respiratory_system_inflammati0.97929589
83MP0009278_abnormal_bone_marrow0.97335760
84MP0005646_abnormal_pituitary_gland0.97088198
85MP0003890_abnormal_embryonic-extraembry0.96342886
86MP0002233_abnormal_nose_morphology0.95428207
87MP0001299_abnormal_eye_distance/0.94561220
88MP0002095_abnormal_skin_pigmentation0.92533931
89MP0001915_intracranial_hemorrhage0.91968554
90MP0006035_abnormal_mitochondrial_morpho0.90524708
91MP0001853_heart_inflammation0.90346918
92MP0010155_abnormal_intestine_physiology0.88188629
93MP0000372_irregular_coat_pigmentation0.88061647
94MP0001188_hyperpigmentation0.87389369
95* MP0002723_abnormal_immune_serum0.86712151
96MP0004233_abnormal_muscle_weight0.85823614
97MP0004264_abnormal_extraembryonic_tissu0.85675015
98MP0003300_gastrointestinal_ulcer0.85593782
99MP0003950_abnormal_plasma_membrane0.85497721
100* MP0001145_abnormal_male_reproductive0.85151758
101MP0005621_abnormal_cell_physiology0.83434105
102MP0008995_early_reproductive_senescence0.83339725
103MP0003718_maternal_effect0.83056842
104MP0000465_gastrointestinal_hemorrhage0.82682244
105MP0000631_abnormal_neuroendocrine_gland0.82156769
106MP0003385_abnormal_body_wall0.81839827
107MP0001119_abnormal_female_reproductive0.81455325
108MP0003448_altered_tumor_morphology0.80816476
109MP0003936_abnormal_reproductive_system0.80680765
110MP0003787_abnormal_imprinting0.80519512
111* MP0000653_abnormal_sex_gland0.79660167
112MP0005395_other_phenotype0.79302353
113MP0010234_abnormal_vibrissa_follicle0.79196404
114MP0000647_abnormal_sebaceous_gland0.78886093
115MP0005220_abnormal_exocrine_pancreas0.78424124
116MP0005174_abnormal_tail_pigmentation0.77777714
117MP0005000_abnormal_immune_tolerance0.77648493
118MP0004147_increased_porphyrin_level0.77534632
119MP0001929_abnormal_gametogenesis0.77075560
120MP0000358_abnormal_cell_content/0.76439217
121MP0003315_abnormal_perineum_morphology0.76433561
122MP0001293_anophthalmia0.76396545
123MP0003755_abnormal_palate_morphology0.76024048
124MP0005384_cellular_phenotype0.75185650
125MP0003705_abnormal_hypodermis_morpholog0.74279355
126MP0004134_abnormal_chest_morphology0.74278748
127MP0000627_abnormal_mammary_gland0.73663331
128MP0009053_abnormal_anal_canal0.72920948
129MP0003119_abnormal_digestive_system0.72750015
130MP0001286_abnormal_eye_development0.72624272
131MP0003698_abnormal_male_reproductive0.72527758
132MP0000477_abnormal_intestine_morphology0.71715855
133MP0005187_abnormal_penis_morphology0.71343319
134MP0005647_abnormal_sex_gland0.70902926
135MP0003868_abnormal_feces_composition0.70503465
136MP0000432_abnormal_head_morphology0.70327627
137MP0002697_abnormal_eye_size0.70123338
138MP0001177_atelectasis0.69873488
139MP0001790_abnormal_immune_system0.69784497
140MP0005387_immune_system_phenotype0.69784497
141MP0003935_abnormal_craniofacial_develop0.69345234
142MP0000762_abnormal_tongue_morphology0.68889647
143MP0003699_abnormal_female_reproductive0.68875969
144MP0003656_abnormal_erythrocyte_physiolo0.67645792
145MP0000383_abnormal_hair_follicle0.67178459
146MP0002177_abnormal_outer_ear0.66966030
147MP0005025_abnormal_response_to0.66563438
148MP0002163_abnormal_gland_morphology0.66503580
149MP0009703_decreased_birth_body0.66230819
150MP0003937_abnormal_limbs/digits/tail_de0.66212018
151MP0009672_abnormal_birth_weight0.63764241
152MP0005310_abnormal_salivary_gland0.60841836
153MP0002132_abnormal_respiratory_system0.60449916
154MP0002075_abnormal_coat/hair_pigmentati0.59036890
155MP0002419_abnormal_innate_immunity0.58599091

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.06236615
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76750418
3* Chromsome breakage (HP:0040012)3.76750418
4Reticulocytopenia (HP:0001896)3.63457731
5Birth length less than 3rd percentile (HP:0003561)3.42406332
6* Abnormality of chromosome stability (HP:0003220)3.40493686
7Colon cancer (HP:0003003)3.34179977
8Abnormality of the fingertips (HP:0001211)3.08786410
9Abnormality of the preputium (HP:0100587)3.08596400
10Medulloblastoma (HP:0002885)2.98005814
11Acute myeloid leukemia (HP:0004808)2.96726119
12Myelodysplasia (HP:0002863)2.91555116
13Ectopic kidney (HP:0000086)2.86705551
14Aplastic anemia (HP:0001915)2.83896709
15Agnosia (HP:0010524)2.82075889
16Thrombocytosis (HP:0001894)2.81468924
17Tubulointerstitial nephritis (HP:0001970)2.78719652
18Meckel diverticulum (HP:0002245)2.77923556
1911 pairs of ribs (HP:0000878)2.76279646
20Aplasia/Hypoplasia of the uvula (HP:0010293)2.73938969
21Selective tooth agenesis (HP:0001592)2.66491873
22Deviation of the thumb (HP:0009603)2.63555354
23Proximal placement of thumb (HP:0009623)2.59372244
24Ependymoma (HP:0002888)2.58914929
25Hypoplastic labia majora (HP:0000059)2.58103235
26Abnormality of the ileum (HP:0001549)2.57506546
27Nephroblastoma (Wilms tumor) (HP:0002667)2.56612752
28Oral leukoplakia (HP:0002745)2.56441045
29Increased nuchal translucency (HP:0010880)2.55924529
30Abnormality of cells of the erythroid lineage (HP:0012130)2.53095733
31Rhabdomyosarcoma (HP:0002859)2.47581034
32Embryonal renal neoplasm (HP:0011794)2.46558797
33IgM deficiency (HP:0002850)2.44895235
34Prominent nose (HP:0000448)2.43359878
35Small intestinal stenosis (HP:0012848)2.43144579
36Duodenal stenosis (HP:0100867)2.43144579
37Renal cortical cysts (HP:0000803)2.41888316
38Impulsivity (HP:0100710)2.41406203
39Abnormal number of erythroid precursors (HP:0012131)2.38543939
40Abnormality of cochlea (HP:0000375)2.38140972
41Long eyelashes (HP:0000527)2.33980556
42Basal cell carcinoma (HP:0002671)2.33427459
43Patellar aplasia (HP:0006443)2.33316844
44Abnormality of the labia majora (HP:0012881)2.30866702
45Breast hypoplasia (HP:0003187)2.26073705
46Amaurosis fugax (HP:0100576)2.24347584
47Lymphoma (HP:0002665)2.23575967
48Biliary tract neoplasm (HP:0100574)2.23029233
49Papillary thyroid carcinoma (HP:0002895)2.20931211
50Clubbing of toes (HP:0100760)2.20798745
51Pallor (HP:0000980)2.20476866
52Squamous cell carcinoma (HP:0002860)2.19740665
53Sloping forehead (HP:0000340)2.18246191
54Absent thumb (HP:0009777)2.15265273
55Poikiloderma (HP:0001029)2.15037074
56Urethral obstruction (HP:0000796)2.15016637
57Bone marrow hypocellularity (HP:0005528)2.14567752
58Blepharitis (HP:0000498)2.13497814
59Pancreatic fibrosis (HP:0100732)2.11964476
60Aplasia/Hypoplasia of the patella (HP:0006498)2.11761442
61Premature graying of hair (HP:0002216)2.11746360
62Neoplasm of the pancreas (HP:0002894)2.08697005
63High pitched voice (HP:0001620)2.07860612
64Abnormality of the carotid arteries (HP:0005344)2.04057115
65Abnormality of the renal cortex (HP:0011035)2.02221049
66Abnormal number of incisors (HP:0011064)2.01870275
67Neoplasm of the oral cavity (HP:0100649)2.01196727
68Abnormality of DNA repair (HP:0003254)2.00579556
69Abnormality of the labia minora (HP:0012880)1.99302120
70Deep philtrum (HP:0002002)1.99254933
71Cafe-au-lait spot (HP:0000957)1.98544288
72Recurrent viral infections (HP:0004429)1.96538571
73Prostate neoplasm (HP:0100787)1.96233257
74Neoplasm of the colon (HP:0100273)1.95969401
75Facial hemangioma (HP:0000329)1.95770677
76Acute lymphatic leukemia (HP:0006721)1.93168478
77Pulmonary fibrosis (HP:0002206)1.93050554
78Abnormality of the duodenum (HP:0002246)1.93036716
79Missing ribs (HP:0000921)1.92283055
80Microglossia (HP:0000171)1.92087004
81Abnormality of B cell number (HP:0010975)1.91523734
82B lymphocytopenia (HP:0010976)1.91523734
83Abnormality of the columella (HP:0009929)1.91394773
84Cutaneous melanoma (HP:0012056)1.90948454
85Capillary hemangiomas (HP:0005306)1.90493589
86Recurrent bronchitis (HP:0002837)1.90351276
87Abnormality of the renal collecting system (HP:0004742)1.87791283
88Duplicated collecting system (HP:0000081)1.85902285
89Aplasia/Hypoplasia of the sternum (HP:0006714)1.84167380
90Entropion (HP:0000621)1.80607681
91Cystic liver disease (HP:0006706)1.80312175
92Poor coordination (HP:0002370)1.80150670
93Atresia of the external auditory canal (HP:0000413)1.79738204
94Oligodactyly (hands) (HP:0001180)1.79322709
95Overlapping toe (HP:0001845)1.79319100
96Lip pit (HP:0100267)1.78871579
97Absent radius (HP:0003974)1.77825629
98T lymphocytopenia (HP:0005403)1.77518892
99IgA deficiency (HP:0002720)1.77009342
100Tracheoesophageal fistula (HP:0002575)1.76954847
101Abnormal spermatogenesis (HP:0008669)1.76505446
102Macrocytic anemia (HP:0001972)1.76451079
103Carpal bone hypoplasia (HP:0001498)1.75449366
104Leukopenia (HP:0001882)1.74932027
105Sandal gap (HP:0001852)1.74884072
106Short 4th metacarpal (HP:0010044)1.74385712
107Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.74385712
108Abnormal lung lobation (HP:0002101)1.74263310
109Short thumb (HP:0009778)1.74106785
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73652576
111Triphalangeal thumb (HP:0001199)1.73465989
112Malignant gastrointestinal tract tumors (HP:0006749)1.73345904
113Gastrointestinal carcinoma (HP:0002672)1.73345904
114Gonadotropin excess (HP:0000837)1.71737925
115Abnormality of the prostate (HP:0008775)1.71338653
116Nephronophthisis (HP:0000090)1.71187237
117Abnormality of methionine metabolism (HP:0010901)1.71179153
118Pancreatic cysts (HP:0001737)1.71063948
119Glioma (HP:0009733)1.71012193
120Neoplasm of the small intestine (HP:0100833)1.70441726
121Truncal obesity (HP:0001956)1.70408747
122Astrocytoma (HP:0009592)1.70211655
123Abnormality of the astrocytes (HP:0100707)1.70211655
124Labial hypoplasia (HP:0000066)1.69250113
125Hyperglycinemia (HP:0002154)1.68790223
126Congenital primary aphakia (HP:0007707)1.68721366
127Small hand (HP:0200055)1.68103988
128Hypoplastic female external genitalia (HP:0012815)1.66218135
129Supernumerary spleens (HP:0009799)1.65708615
130Aplasia involving forearm bones (HP:0009822)1.63489278
131Absent forearm bone (HP:0003953)1.63489278
132Medial flaring of the eyebrow (HP:0010747)1.63439326
133Choanal atresia (HP:0000453)1.62767922
134Short chin (HP:0000331)1.61769406
135Abnormality of the renal medulla (HP:0100957)1.60922667
136Embryonal neoplasm (HP:0002898)1.60485361
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.59346779
138Thyroid carcinoma (HP:0002890)1.59204008
139Astigmatism (HP:0000483)1.58037679
140Genital tract atresia (HP:0001827)1.57493978
141Morphological abnormality of the inner ear (HP:0011390)1.54391920
142Methylmalonic acidemia (HP:0002912)1.53661430
143Gait imbalance (HP:0002141)1.53653940
144Abnormality of midbrain morphology (HP:0002418)1.51620795
145Molar tooth sign on MRI (HP:0002419)1.51620795
146Premature ovarian failure (HP:0008209)1.50998510
147Septate vagina (HP:0001153)1.50940489
148Polycystic kidney dysplasia (HP:0000113)1.50839489
149Arteriovenous malformation (HP:0100026)1.50467899
150Abnormal hair whorl (HP:0010721)1.48547564
151Fair hair (HP:0002286)1.47976208
152Pili torti (HP:0003777)1.46217983
153Chronic hepatic failure (HP:0100626)1.45238599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.08090788
2WEE13.16360917
3CDK123.10114720
4NEK22.69330803
5TTK2.50124228
6EIF2AK12.37169531
7PNCK2.36904896
8BUB12.32792834
9PLK42.16536630
10BRSK22.16297885
11ACVR1B2.11531849
12ATR2.09448987
13SRPK12.08636445
14MST1R1.96035229
15RPS6KB21.90516557
16STK101.87524504
17MKNK11.81069042
18AURKB1.79732478
19AKT31.78399470
20PLK11.78136082
21RPS6KA41.75233913
22TSSK61.74079417
23FRK1.71807472
24EEF2K1.67083574
25CDK71.63282448
26MET1.62913815
27MAP4K11.60836465
28CAMK1G1.59116571
29CHEK21.51652532
30CDK41.49648583
31STK41.46740960
32PLK31.45657734
33CDK61.41405484
34TGFBR11.39680896
35NEK11.39414396
36NME21.38385199
37CHEK11.37750158
38VRK11.37169681
39FLT31.34999791
40BRD41.30213405
41SCYL21.27494931
42* ATM1.26553933
43TLK11.24913417
44MAP3K81.24221626
45BCR1.24198986
46PASK1.22519412
47TEC1.18720484
48TAOK31.18028486
49BMPR1B1.17570207
50NUAK11.15566555
51CDK81.14747567
52STK391.14683381
53ZAK1.13077836
54STK31.11214887
55JAK31.09895397
56WNK41.09600560
57CSNK1E1.08983642
58PIM11.08830449
59CAMK1D1.07251191
60MKNK21.06039797
61TRIM281.06007736
62MELK1.04386554
63LRRK21.02097908
64LATS11.00857417
65TNIK0.99134981
66IRAK40.97934708
67PLK20.95152395
68CDK90.92985359
69EIF2AK30.92385179
70ERBB30.92381041
71BRSK10.91959700
72PKN20.90332125
73KIT0.89846537
74CDK20.87887009
75CDK30.84834153
76PDK20.84803073
77WNK10.84438314
78BTK0.83469721
79PAK30.82685307
80DYRK30.82494604
81CHUK0.77609410
82CCNB10.77060161
83TRPM70.76841954
84RAF10.76671891
85CLK10.74672458
86CSF1R0.74089668
87BRAF0.72494023
88MAP3K100.72084475
89TXK0.71425341
90PIK3CA0.70692015
91FGFR10.70030940
92PAK40.67788188
93CDK10.67225330
94PINK10.63816850
95ALK0.62669970
96PRKCI0.62242047
97AURKA0.61942196
98NME10.61829278
99CSNK2A20.61290381
100NEK90.61285447
101NEK60.60397922
102MAP3K40.58144967
103RPS6KA50.57950221
104CSNK1A1L0.57568562
105RPS6KB10.57150641
106IKBKB0.54172459
107MST40.53141984
108EIF2AK20.51969167
109GSK3B0.51420518
110MAP3K140.51097611
111MAPKAPK50.50477461
112CSNK1G10.49446934
113MTOR0.49115951
114PBK0.48152763
115MAP3K90.47815443
116MAP3K60.47246972
117TYK20.47073704
118CSNK2A10.46931364
119KSR10.46006197
120* PRKDC0.45835295
121MARK30.45202956
122AKT20.44313937
123STK240.44234490
124MAP2K30.43547980
125SGK10.42303316
126STK160.39755942
127LCK0.39604016
128EPHA20.39371449
129PRKACB0.39153885
130CSNK1A10.38397557
131MAPK140.38053654
132CSNK1D0.37540425
133ITK0.37478079
134TAF10.37418778
135MAPK100.37388407
136AKT10.34628410
137PAK20.32750179
138DMPK0.32544290
139STK38L0.31690550
140ZAP700.31554896
141TESK20.31051898

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77606548
2Mismatch repair_Homo sapiens_hsa034304.22520954
3* Homologous recombination_Homo sapiens_hsa034403.18384016
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.10719439
5Cell cycle_Homo sapiens_hsa041102.98487457
6Base excision repair_Homo sapiens_hsa034102.91307044
7RNA transport_Homo sapiens_hsa030132.77164173
8Nucleotide excision repair_Homo sapiens_hsa034202.74797557
9Ribosome_Homo sapiens_hsa030102.72779390
10Spliceosome_Homo sapiens_hsa030402.66882980
11Fanconi anemia pathway_Homo sapiens_hsa034602.59277454
12Protein export_Homo sapiens_hsa030602.45925637
13* Non-homologous end-joining_Homo sapiens_hsa034502.38690313
14RNA polymerase_Homo sapiens_hsa030202.31011880
15One carbon pool by folate_Homo sapiens_hsa006702.21323773
16RNA degradation_Homo sapiens_hsa030182.18798083
17Propanoate metabolism_Homo sapiens_hsa006402.01516198
18p53 signaling pathway_Homo sapiens_hsa041151.90643881
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.88273477
20Pyrimidine metabolism_Homo sapiens_hsa002401.87075719
21Basal transcription factors_Homo sapiens_hsa030221.71629660
22mRNA surveillance pathway_Homo sapiens_hsa030151.66129667
23Proteasome_Homo sapiens_hsa030501.54674938
24Antigen processing and presentation_Homo sapiens_hsa046121.51157439
25Pyruvate metabolism_Homo sapiens_hsa006201.39318865
26Primary immunodeficiency_Homo sapiens_hsa053401.38721079
27Herpes simplex infection_Homo sapiens_hsa051681.35571741
28Systemic lupus erythematosus_Homo sapiens_hsa053221.32986453
29Viral carcinogenesis_Homo sapiens_hsa052031.22278480
30Epstein-Barr virus infection_Homo sapiens_hsa051691.20443810
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20131504
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14978290
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13583185
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10361932
35MicroRNAs in cancer_Homo sapiens_hsa052061.09243118
36Fatty acid biosynthesis_Homo sapiens_hsa000611.08985810
37Small cell lung cancer_Homo sapiens_hsa052221.06537140
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06521518
39NF-kappa B signaling pathway_Homo sapiens_hsa040641.04946138
40HTLV-I infection_Homo sapiens_hsa051661.01541966
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00165739
42Transcriptional misregulation in cancer_Homo sapiens_hsa052020.97984990
43Intestinal immune network for IgA production_Homo sapiens_hsa046720.96428411
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95542849
45Measles_Homo sapiens_hsa051620.94929496
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94910607
47Purine metabolism_Homo sapiens_hsa002300.91230919
48Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90793165
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89928508
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89040968
51Circadian rhythm_Homo sapiens_hsa047100.86214797
52Fatty acid metabolism_Homo sapiens_hsa012120.86030659
53Steroid biosynthesis_Homo sapiens_hsa001000.85687063
54Hematopoietic cell lineage_Homo sapiens_hsa046400.85350155
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.84459891
56Butanoate metabolism_Homo sapiens_hsa006500.83010096
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82070935
58Leishmaniasis_Homo sapiens_hsa051400.81339644
59Thyroid cancer_Homo sapiens_hsa052160.81047881
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80529748
61Hepatitis B_Homo sapiens_hsa051610.80391311
62Oocyte meiosis_Homo sapiens_hsa041140.78033599
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77765998
64Chronic myeloid leukemia_Homo sapiens_hsa052200.75234842
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73235393
66Legionellosis_Homo sapiens_hsa051340.72662048
67Apoptosis_Homo sapiens_hsa042100.72588788
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.70948939
69B cell receptor signaling pathway_Homo sapiens_hsa046620.69656836
70Pancreatic cancer_Homo sapiens_hsa052120.69272411
71TGF-beta signaling pathway_Homo sapiens_hsa043500.68846493
72Adherens junction_Homo sapiens_hsa045200.68840606
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66819555
74Viral myocarditis_Homo sapiens_hsa054160.66090916
75Caffeine metabolism_Homo sapiens_hsa002320.65349465
76Biosynthesis of amino acids_Homo sapiens_hsa012300.64329150
77Colorectal cancer_Homo sapiens_hsa052100.63870567
78Shigellosis_Homo sapiens_hsa051310.63532497
79Influenza A_Homo sapiens_hsa051640.62689653
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62312737
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61679493
82Folate biosynthesis_Homo sapiens_hsa007900.61464446
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.60605284
84Vitamin B6 metabolism_Homo sapiens_hsa007500.59227601
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59093669
86Huntingtons disease_Homo sapiens_hsa050160.57624465
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.57481845
88Prostate cancer_Homo sapiens_hsa052150.56533675
89Toxoplasmosis_Homo sapiens_hsa051450.55279717
90Asthma_Homo sapiens_hsa053100.54266255
91Allograft rejection_Homo sapiens_hsa053300.53506135
92Fatty acid degradation_Homo sapiens_hsa000710.53491400
93Acute myeloid leukemia_Homo sapiens_hsa052210.53102833
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50254890
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49943090
96Carbon metabolism_Homo sapiens_hsa012000.49169555
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.49149044
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48340835
99Thyroid hormone synthesis_Homo sapiens_hsa049180.48143182
100Lysine degradation_Homo sapiens_hsa003100.47135810
101Pathways in cancer_Homo sapiens_hsa052000.46605845
102mTOR signaling pathway_Homo sapiens_hsa041500.46215488
103Metabolic pathways_Homo sapiens_hsa011000.44981165
104Wnt signaling pathway_Homo sapiens_hsa043100.43564237
105Pentose phosphate pathway_Homo sapiens_hsa000300.43032115
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42763897
107Osteoclast differentiation_Homo sapiens_hsa043800.42649020
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42274767
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41945642
110T cell receptor signaling pathway_Homo sapiens_hsa046600.41071973
111Retinol metabolism_Homo sapiens_hsa008300.40636446
112Non-small cell lung cancer_Homo sapiens_hsa052230.40586322
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40177196
114HIF-1 signaling pathway_Homo sapiens_hsa040660.39894581
115beta-Alanine metabolism_Homo sapiens_hsa004100.39501150
116Autoimmune thyroid disease_Homo sapiens_hsa053200.38982349
117Arginine and proline metabolism_Homo sapiens_hsa003300.37869623
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37509326
119N-Glycan biosynthesis_Homo sapiens_hsa005100.37419412
120Fatty acid elongation_Homo sapiens_hsa000620.36396039
121Platelet activation_Homo sapiens_hsa046110.36187784
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36047144
123Glucagon signaling pathway_Homo sapiens_hsa049220.35841563
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35560764
125Oxidative phosphorylation_Homo sapiens_hsa001900.35526432
126Selenocompound metabolism_Homo sapiens_hsa004500.34770120
127Parkinsons disease_Homo sapiens_hsa050120.34601731
128Notch signaling pathway_Homo sapiens_hsa043300.34431463
129Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33472653
130TNF signaling pathway_Homo sapiens_hsa046680.33423285
131FoxO signaling pathway_Homo sapiens_hsa040680.33412856
132Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.30910234
133Melanoma_Homo sapiens_hsa052180.29708571
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28730829
135Alcoholism_Homo sapiens_hsa050340.28712492
136Proteoglycans in cancer_Homo sapiens_hsa052050.28667759
137Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28589067
138Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28556183
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.27442509
140Cysteine and methionine metabolism_Homo sapiens_hsa002700.27351958
141Hedgehog signaling pathway_Homo sapiens_hsa043400.26618816
142Arginine biosynthesis_Homo sapiens_hsa002200.25985195
143Tryptophan metabolism_Homo sapiens_hsa003800.25133055
144Renin-angiotensin system_Homo sapiens_hsa046140.25097219
145Tight junction_Homo sapiens_hsa045300.24962243
146ABC transporters_Homo sapiens_hsa020100.24827915
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24809108
148Hippo signaling pathway_Homo sapiens_hsa043900.23797848
149PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23772287
150Starch and sucrose metabolism_Homo sapiens_hsa005000.23105468
151Peroxisome_Homo sapiens_hsa041460.23101892
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22932478
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.22817732
154Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22546491
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21300964
156AMPK signaling pathway_Homo sapiens_hsa041520.21111811
157Inositol phosphate metabolism_Homo sapiens_hsa005620.21064058
158Long-term depression_Homo sapiens_hsa047300.20442387
159Olfactory transduction_Homo sapiens_hsa047400.20290483
160Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19782299

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