RABL2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The RABL2B protein is a member of the RAB gene family which belongs to the RAS GTPase superfamily. RABL2B is located within a subtelomeric region of 22q13.3. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.62604392
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.24018788
3poly(A)+ mRNA export from nucleus (GO:0016973)8.95287817
4motile cilium assembly (GO:0044458)8.75599467
5epithelial cilium movement (GO:0003351)8.56172700
6modulation by virus of host process (GO:0019054)7.85485570
7phosphatidylinositol acyl-chain remodeling (GO:0036149)7.08619763
8axoneme assembly (GO:0035082)7.07922011
9phosphatidylserine acyl-chain remodeling (GO:0036150)6.92730911
10modulation by symbiont of host cellular process (GO:0044068)6.01204086
11regulation of cilium movement (GO:0003352)5.72412742
12left/right pattern formation (GO:0060972)5.45618653
13neutrophil activation involved in immune response (GO:0002283)5.40766079
14phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.38549390
15negative regulation of viral entry into host cell (GO:0046597)5.06535563
16calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.03595551
17left/right axis specification (GO:0070986)4.86756157
18positive regulation of tolerance induction (GO:0002645)4.69952744
19negative regulation of viral release from host cell (GO:1902187)4.61096649
20cilium organization (GO:0044782)4.55848772
21cilium morphogenesis (GO:0060271)4.53998657
22cilium assembly (GO:0042384)4.43941837
23regulation of translational fidelity (GO:0006450)4.41694063
24phosphatidylcholine acyl-chain remodeling (GO:0036151)4.40825118
25regulation of germinal center formation (GO:0002634)4.21486688
26amyloid precursor protein catabolic process (GO:0042987)4.12797884
27microtubule bundle formation (GO:0001578)4.12685574
28intraciliary transport (GO:0042073)4.05336943
29phosphatidylserine metabolic process (GO:0006658)4.00031289
30protein localization to cilium (GO:0061512)3.93836244
31regulation of viral entry into host cell (GO:0046596)3.88083821
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.83212679
33ventricular system development (GO:0021591)3.77535420
34regulation of microtubule-based movement (GO:0060632)3.68595225
35vitamin transmembrane transport (GO:0035461)3.65828003
36protein polyglutamylation (GO:0018095)3.63529953
37tolerance induction (GO:0002507)3.62361076
38response to xenobiotic stimulus (GO:0009410)3.59064120
39vesicle targeting (GO:0006903)3.55126221
40regulation of tolerance induction (GO:0002643)3.49866208
41mitochondrion degradation (GO:0000422)3.48562611
42cellular component assembly involved in morphogenesis (GO:0010927)3.45763347
43brain morphogenesis (GO:0048854)3.41803097
44negative regulation of T cell differentiation in thymus (GO:0033085)3.38285716
45primary alcohol catabolic process (GO:0034310)3.37508605
46centriole assembly (GO:0098534)3.37175184
47modulation by virus of host morphology or physiology (GO:0019048)3.30755418
48ethanol metabolic process (GO:0006067)3.29879643
49smoothened signaling pathway (GO:0007224)3.25192819
50autophagic vacuole fusion (GO:0000046)3.22999891
51regulation of viral release from host cell (GO:1902186)3.22645323
52dorsal/ventral neural tube patterning (GO:0021904)3.17904938
53alditol phosphate metabolic process (GO:0052646)3.15875377
54piRNA metabolic process (GO:0034587)3.13263316
55multicellular organism reproduction (GO:0032504)3.11439733
56one-carbon compound transport (GO:0019755)3.09299219
57base-excision repair, AP site formation (GO:0006285)3.08684418
58negative regulation of immunoglobulin mediated immune response (GO:0002890)3.04564166
59negative regulation of B cell mediated immunity (GO:0002713)3.04564166
60neutrophil activation (GO:0042119)3.04130383
61cell projection assembly (GO:0030031)3.02717554
62macrophage activation involved in immune response (GO:0002281)3.01915421
63basic amino acid transport (GO:0015802)2.94984671
64lung epithelium development (GO:0060428)2.94850928
65negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.90790487
66diterpenoid biosynthetic process (GO:0016102)2.86006375
67photoreceptor cell maintenance (GO:0045494)2.85821405
68microtubule-based movement (GO:0007018)2.84448577
69DNA methylation involved in gamete generation (GO:0043046)2.82568339
70activated T cell proliferation (GO:0050798)2.81408540
71regulation of regulatory T cell differentiation (GO:0045589)2.72556259
72cerebral cortex neuron differentiation (GO:0021895)2.70473847
73regulation of meiosis I (GO:0060631)2.67863200
74seminiferous tubule development (GO:0072520)2.64218395
75amyloid precursor protein metabolic process (GO:0042982)2.63297927
76S-adenosylmethionine metabolic process (GO:0046500)2.61783762
77ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.61754590
78retinoic acid metabolic process (GO:0042573)2.61694662
79exogenous drug catabolic process (GO:0042738)2.59938467
80regulation of interleukin-5 production (GO:0032674)2.57425044
81granulocyte activation (GO:0036230)2.57023940
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.56133196
83ethanol oxidation (GO:0006069)2.54923611
84CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.53933700
85cytoplasmic microtubule organization (GO:0031122)2.52858160
86beta-amyloid metabolic process (GO:0050435)2.52408218
87phosphatidylcholine metabolic process (GO:0046470)2.49573835
88negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.48342015
89regulation of translational elongation (GO:0006448)2.48248403
90sperm motility (GO:0030317)2.47299209
91organelle membrane fusion (GO:0090174)2.46432063
92lateral ventricle development (GO:0021670)2.43808575
93Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43440402
94lateral sprouting from an epithelium (GO:0060601)2.42908173
95nonmotile primary cilium assembly (GO:0035058)2.42183281
96organic cation transport (GO:0015695)2.40135875
97regulation of interleukin-13 production (GO:0032656)2.40131558
98pyrimidine-containing compound transmembrane transport (GO:0072531)2.40032239
99axonemal dynein complex assembly (GO:0070286)12.6486555
100cilium or flagellum-dependent cell motility (GO:0001539)11.9536975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1DROSHA_22980978_ChIP-Seq_HELA_Human2.98180455
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80098479
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68932248
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.67447298
5ZNF274_21170338_ChIP-Seq_K562_Hela2.17901353
6VDR_22108803_ChIP-Seq_LS180_Human2.09682516
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.08621366
8EZH2_22144423_ChIP-Seq_EOC_Human2.00790470
9IGF1R_20145208_ChIP-Seq_DFB_Human1.83370985
10PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.75757482
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74491303
12EZH2_27294783_Chip-Seq_ESCs_Mouse1.70584865
13GBX2_23144817_ChIP-Seq_PC3_Human1.66632771
14ERA_21632823_ChIP-Seq_H3396_Human1.62806683
15EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.62424946
16STAT1_20625510_ChIP-Seq_HELA_Human1.51612526
17REST_21632747_ChIP-Seq_MESCs_Mouse1.50770077
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45677819
19CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43686429
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.43365657
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42993902
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42032611
23SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40326256
24EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.39947695
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.37214504
26SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.35673747
27RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32577134
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.32359567
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29471031
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.28211563
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.27630562
32RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.27414277
33AR_21572438_ChIP-Seq_LNCaP_Human1.26526111
34MYC_19829295_ChIP-Seq_ESCs_Human1.25683189
35P68_20966046_ChIP-Seq_HELA_Human1.25258003
36PHF8_20622854_ChIP-Seq_HELA_Human1.24690939
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23622099
38HOXB7_26014856_ChIP-Seq_BT474_Human1.22244298
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21560476
40E2F1_20622854_ChIP-Seq_HELA_Human1.21015417
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19400377
42P53_21459846_ChIP-Seq_SAOS-2_Human1.19094613
43GATA3_21878914_ChIP-Seq_MCF-7_Human1.16156158
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15511664
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.13977211
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13353542
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11873766
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11873766
49BCL6_27268052_Chip-Seq_Bcells_Human1.11211796
50CTCF_27219007_Chip-Seq_Bcells_Human1.10794897
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10566895
52CTCF_20526341_ChIP-Seq_ESCs_Human1.09462884
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.08341955
54AHR_22903824_ChIP-Seq_MCF-7_Human1.08102063
55TAF2_19829295_ChIP-Seq_ESCs_Human1.07725004
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07662770
57SMC4_20622854_ChIP-Seq_HELA_Human1.07351898
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07265050
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06498336
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06488493
61SMAD3_21741376_ChIP-Seq_HESCs_Human1.04973224
62OCT4_20526341_ChIP-Seq_ESCs_Human1.03818242
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.01991461
64AR_25329375_ChIP-Seq_VCAP_Human1.01829544
65TP63_22573176_ChIP-Seq_HFKS_Human1.01637805
66MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01591288
67TCF4_23295773_ChIP-Seq_U87_Human1.01398046
68BCAT_22108803_ChIP-Seq_LS180_Human1.01389618
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01177740
70TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01009573
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00449814
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00087114
73TCF4_22108803_ChIP-Seq_LS180_Human1.00011296
74MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.99810844
75OCT4_19829295_ChIP-Seq_ESCs_Human0.99746814
76FOXH1_21741376_ChIP-Seq_ESCs_Human0.98967961
77SMRT_27268052_Chip-Seq_Bcells_Human0.98864595
78TP53_22573176_ChIP-Seq_HFKS_Human0.98852291
79PRDM14_20953172_ChIP-Seq_ESCs_Human0.96886543
80NANOG_20526341_ChIP-Seq_ESCs_Human0.96881656
81SOX2_21211035_ChIP-Seq_LN229_Human0.96192340
82SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.95959878
83AR_20517297_ChIP-Seq_VCAP_Human0.95634930
84SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.94735942
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93912470
86EED_16625203_ChIP-ChIP_MESCs_Mouse0.93385517
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.93111741
88TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92808335
89CEBPB_22108803_ChIP-Seq_LS180_Human0.92709321
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.91144670
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91144670
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91093020
93SA1_27219007_Chip-Seq_Bcells_Human0.90948821
94ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90430595
95ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90125260
96PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90019199
97CBP_20019798_ChIP-Seq_JUKART_Human0.89457731
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89457731
99KLF4_19829295_ChIP-Seq_ESCs_Human0.89324370
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89100007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.33589359
2MP0006054_spinal_hemorrhage3.86214974
3MP0008875_abnormal_xenobiotic_pharmacok3.57412826
4MP0001984_abnormal_olfaction3.00888052
5MP0004133_heterotaxia2.97512399
6MP0002277_abnormal_respiratory_mucosa2.73628813
7MP0004043_abnormal_pH_regulation2.69774054
8MP0002138_abnormal_hepatobiliary_system2.29268976
9MP0001486_abnormal_startle_reflex2.28854539
10MP0002132_abnormal_respiratory_system2.05672456
11MP0008789_abnormal_olfactory_epithelium2.03383090
12MP0005646_abnormal_pituitary_gland1.81138249
13MP0003329_amyloid_beta_deposits1.80609460
14MP0005551_abnormal_eye_electrophysiolog1.74806448
15MP0001727_abnormal_embryo_implantation1.71571372
16MP0003880_abnormal_central_pattern1.66357766
17MP0003878_abnormal_ear_physiology1.64193173
18MP0005377_hearing/vestibular/ear_phenot1.64193173
19MP0005394_taste/olfaction_phenotype1.63573865
20MP0005499_abnormal_olfactory_system1.63573865
21MP0002735_abnormal_chemical_nociception1.58072635
22MP0003436_decreased_susceptibility_to1.57616701
23MP0009745_abnormal_behavioral_response1.55371211
24MP0002928_abnormal_bile_duct1.53423850
25MP0001968_abnormal_touch/_nociception1.51964311
26MP0002822_catalepsy1.47092324
27MP0002160_abnormal_reproductive_system1.45560324
28MP0010386_abnormal_urinary_bladder1.45463818
29MP0003195_calcinosis1.41698489
30MP0003635_abnormal_synaptic_transmissio1.39577081
31MP0002089_abnormal_postnatal_growth/wei1.39315836
32MP0004859_abnormal_synaptic_plasticity1.38836015
33MP0009046_muscle_twitch1.38678170
34MP0002638_abnormal_pupillary_reflex1.38050021
35MP0004885_abnormal_endolymph1.32194627
36MP0005423_abnormal_somatic_nervous1.32093071
37MP0001986_abnormal_taste_sensitivity1.30217341
38MP0001765_abnormal_ion_homeostasis1.28709404
39MP0004145_abnormal_muscle_electrophysio1.27413317
40MP0002102_abnormal_ear_morphology1.27078029
41MP0001502_abnormal_circadian_rhythm1.26015383
42MP0001485_abnormal_pinna_reflex1.25697157
43MP0002734_abnormal_mechanical_nocicepti1.23407144
44MP0002064_seizures1.22814136
45MP0008872_abnormal_physiological_respon1.21824904
46MP0000604_amyloidosis1.21436118
47MP0006276_abnormal_autonomic_nervous1.19873930
48MP0001188_hyperpigmentation1.19480363
49MP0003136_yellow_coat_color1.19323065
50MP0001790_abnormal_immune_system1.16797091
51MP0005387_immune_system_phenotype1.16797091
52MP0002876_abnormal_thyroid_physiology1.16460778
53MP0002063_abnormal_learning/memory/cond1.15797468
54MP0005171_absent_coat_pigmentation1.15779071
55MP0001970_abnormal_pain_threshold1.14718865
56MP0005645_abnormal_hypothalamus_physiol1.10352577
57MP0002272_abnormal_nervous_system1.10348708
58MP0005671_abnormal_response_to1.08251050
59MP0002572_abnormal_emotion/affect_behav1.08145812
60MP0000566_synostosis1.06524493
61MP0004742_abnormal_vestibular_system1.06145501
62MP0002909_abnormal_adrenal_gland1.04943937
63MP0002229_neurodegeneration1.04344296
64MP0000631_abnormal_neuroendocrine_gland1.01111269
65MP0001348_abnormal_lacrimal_gland0.99444454
66MP0002736_abnormal_nociception_after0.97685285
67MP0005389_reproductive_system_phenotype0.94925331
68MP0000955_abnormal_spinal_cord0.94900725
69MP0002557_abnormal_social/conspecific_i0.94041473
70MP0003633_abnormal_nervous_system0.93869544
71MP0009780_abnormal_chondrocyte_physiolo0.93600749
72MP0000778_abnormal_nervous_system0.92721236
73MP0002282_abnormal_trachea_morphology0.86759506
74MP0008877_abnormal_DNA_methylation0.86649189
75MP0003787_abnormal_imprinting0.86404090
76MP0001501_abnormal_sleep_pattern0.83312762
77MP0002733_abnormal_thermal_nociception0.83080050
78MP0005360_urolithiasis0.82867487
79MP0005253_abnormal_eye_physiology0.82507715
80MP0000613_abnormal_salivary_gland0.82097531
81MP0004858_abnormal_nervous_system0.81520113
82MP0000026_abnormal_inner_ear0.81358644
83MP0000467_abnormal_esophagus_morphology0.81314988
84MP0004019_abnormal_vitamin_homeostasis0.79766805
85MP0003879_abnormal_hair_cell0.79209552
86MP0001835_abnormal_antigen_presentation0.78379742
87MP0002882_abnormal_neuron_morphology0.78341882
88MP0005386_behavior/neurological_phenoty0.77201732
89MP0004924_abnormal_behavior0.77201732
90MP0003656_abnormal_erythrocyte_physiolo0.77199324
91MP0002752_abnormal_somatic_nervous0.76879124
92MP0002168_other_aberrant_phenotype0.76610234
93MP0005248_abnormal_Harderian_gland0.76502744
94MP0004142_abnormal_muscle_tone0.74877381
95MP0003866_abnormal_defecation0.74002439
96MP0001905_abnormal_dopamine_level0.73735581
97MP0001963_abnormal_hearing_physiology0.73695573
98MP0009785_altered_susceptibility_to0.73414497
99MP0005174_abnormal_tail_pigmentation0.72269589
100MP0002184_abnormal_innervation0.72002967

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.31298803
2Abnormal respiratory epithelium morphology (HP:0012253)8.70802996
3Abnormal respiratory motile cilium morphology (HP:0005938)8.70802996
4Dynein arm defect of respiratory motile cilia (HP:0012255)8.53325040
5Absent/shortened dynein arms (HP:0200106)8.53325040
6Abnormal respiratory motile cilium physiology (HP:0012261)8.21560917
7Abnormal ciliary motility (HP:0012262)8.14742238
8Rhinitis (HP:0012384)7.39966859
9Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)7.11513420
10Agnosia (HP:0010524)6.27784584
11Chronic bronchitis (HP:0004469)5.74014131
12Bronchiectasis (HP:0002110)5.51599468
13Nasal polyposis (HP:0100582)4.73037715
14Disinhibition (HP:0000734)4.35475682
15Pancreatic fibrosis (HP:0100732)4.10572836
16True hermaphroditism (HP:0010459)4.07310264
17Occipital encephalocele (HP:0002085)3.81648419
18Abnormality of the nasal mucosa (HP:0000433)3.76866573
19Abnormality of midbrain morphology (HP:0002418)3.76453709
20Molar tooth sign on MRI (HP:0002419)3.76453709
21Pancreatic cysts (HP:0001737)3.67257816
22Recurrent sinusitis (HP:0011108)3.58577206
23Nephronophthisis (HP:0000090)3.45787326
24Chronic hepatic failure (HP:0100626)3.41744610
25Cystic liver disease (HP:0006706)3.32580618
26Bronchitis (HP:0012387)3.23904070
27Axonal loss (HP:0003447)3.19642134
28Infertility (HP:0000789)3.19594179
29Chronic sinusitis (HP:0011109)3.15244626
30Inappropriate behavior (HP:0000719)3.12538101
31Progressive external ophthalmoplegia (HP:0000590)2.94259014
32Upper motor neuron abnormality (HP:0002127)2.83630820
33Abnormality of the renal medulla (HP:0100957)2.81325898
34Recurrent otitis media (HP:0000403)2.80931771
35Amyotrophic lateral sclerosis (HP:0007354)2.69800037
36Polyphagia (HP:0002591)2.69651129
37Personality changes (HP:0000751)2.67164032
38Mask-like facies (HP:0000298)2.65297875
39Male infertility (HP:0003251)2.60102665
40Postaxial foot polydactyly (HP:0001830)2.59721399
41Oculomotor apraxia (HP:0000657)2.56170296
42Decreased circulating renin level (HP:0003351)2.50192646
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.50019655
44Asplenia (HP:0001746)2.43517373
45Chronic otitis media (HP:0000389)2.42136099
46Medial flaring of the eyebrow (HP:0010747)2.42096730
47Congenital hepatic fibrosis (HP:0002612)2.33674948
48Neurofibrillary tangles (HP:0002185)2.30388565
49Anencephaly (HP:0002323)2.26916964
50Neck muscle weakness (HP:0000467)2.20135059
51Gait imbalance (HP:0002141)2.19301050
52Hyperactive renin-angiotensin system (HP:0000841)2.12073569
53Congenital primary aphakia (HP:0007707)2.09731411
54Tubular atrophy (HP:0000092)2.08588430
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.07250605
56Abnormality of the renal cortex (HP:0011035)2.06684455
57Abnormal biliary tract physiology (HP:0012439)2.05998330
58Bile duct proliferation (HP:0001408)2.05998330
59Male pseudohermaphroditism (HP:0000037)2.02246633
60Atelectasis (HP:0100750)2.01025724
61Tubulointerstitial nephritis (HP:0001970)2.00383110
62Sclerocornea (HP:0000647)1.93998088
63Nephrogenic diabetes insipidus (HP:0009806)1.89289969
64Basal ganglia calcification (HP:0002135)1.88620351
65Nephropathy (HP:0000112)1.81996802
66Postaxial hand polydactyly (HP:0001162)1.78293355
67Polydipsia (HP:0001959)1.77266003
68Abnormal drinking behavior (HP:0030082)1.77266003
69Abnormal neuron morphology (HP:0012757)1.77226045
70Abnormality of the motor neurons (HP:0002450)1.77226045
71Hypoplasia of the uterus (HP:0000013)1.72418487
72Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70299035
73Recurrent bacterial skin infections (HP:0005406)1.67081718
74Furrowed tongue (HP:0000221)1.66780273
75Abnormal eating behavior (HP:0100738)1.66531017
76Abnormality of renin-angiotensin system (HP:0000847)1.65081987
77Decreased central vision (HP:0007663)1.63231556
78Renal salt wasting (HP:0000127)1.59995817
79Bone cyst (HP:0012062)1.56670310
80Abnormal rod and cone electroretinograms (HP:0008323)1.55389817
81Preaxial hand polydactyly (HP:0001177)1.53868861
82Diminished motivation (HP:0000745)1.53322157
83Tubulointerstitial abnormality (HP:0001969)1.52078989
84Recurrent bronchitis (HP:0002837)1.51953403
85Fetal akinesia sequence (HP:0001989)1.49060444
86Congenital stationary night blindness (HP:0007642)1.46224944
87Absent speech (HP:0001344)1.42455966
88Vaginal atresia (HP:0000148)1.41852298
89Genital tract atresia (HP:0001827)1.41445290
90Hyperaldosteronism (HP:0000859)1.39993530
91External ophthalmoplegia (HP:0000544)1.39992496
92Aplasia/hypoplasia of the uterus (HP:0008684)1.37660252
93Syncope (HP:0001279)1.36523844
94Tubulointerstitial fibrosis (HP:0005576)1.35854655
95Attenuation of retinal blood vessels (HP:0007843)1.35397006
96Hand muscle atrophy (HP:0009130)1.33524119
97Stage 5 chronic kidney disease (HP:0003774)1.32344728
98Memory impairment (HP:0002354)1.31622439
99Polyuria (HP:0000103)1.30943331
100Rib fusion (HP:0000902)1.30364687

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK157.19371199
2BCKDK3.81884021
3EIF2AK13.35960847
4MAPKAPK32.76222496
5SCYL22.71430118
6MAP3K42.58992333
7EEF2K2.55417706
8MAP4K22.40134238
9FRK2.36234644
10PTK2B2.25587741
11TXK1.93379521
12MST41.89285360
13MAPK131.77939715
14DYRK1A1.77837238
15ADRBK21.55691867
16MARK11.52259009
17MAPKAPK51.46698069
18TRPM71.45616300
19EPHA31.31566665
20SYK1.25975230
21MAPK121.22462345
22CSNK1A1L1.22103893
23GRK11.21856571
24WNK41.21524385
25DYRK21.21326262
26PRKCQ1.21138228
27CSNK1G31.20633030
28SIK21.20154272
29CSNK1G21.20130314
30TAOK31.18246560
31NME11.18003792
32BCR1.17424811
33MARK21.16341896
34MAP2K61.15693776
35EPHA21.11363622
36INSRR1.10938077
37EPHA41.09585193
38MAP2K71.07874702
39DAPK21.03156458
40EPHB11.01118654
41NEK20.98571864
42GRK60.95382304
43PINK10.94903861
44WNK30.90041455
45CSNK1G10.86733209
46TLK10.85451251
47LCK0.80467109
48TNK20.77740518
49MUSK0.72878457
50NTRK20.72814903
51CAMKK10.72751375
52MAPK70.71222855
53RPS6KB20.71092814
54NTRK30.70595794
55CDK190.68747067
56MAP2K40.68487655
57PRKCZ0.67847903
58CSK0.67456658
59PHKG20.67251454
60PHKG10.67251454
61ADRBK10.63329399
62SGK4940.62239355
63SGK2230.62239355
64CASK0.60150172
65MAP3K70.59629087
66OXSR10.58066019
67CDK50.57254115
68CDC42BPA0.54411687
69BMPR1B0.53360537
70PRKCI0.52545082
71PRKCG0.51892402
72CSNK1D0.51471884
73ERBB20.50288111
74PRKCD0.48053063
75DYRK1B0.47183836
76FGFR10.46935319
77PAK30.46799964
78PRKCA0.44985601
79PRKACA0.43464243
80MARK30.42439635
81MATK0.42425609
82MAP3K10.42303383
83FES0.42266409
84PRKD30.42084287
85RPS6KA20.41858199
86FYN0.38026700
87ITK0.37570056
88STK110.36989170
89IRAK40.36893853
90TESK10.36302513
91PRKAA10.35250932
92SGK10.34653318
93IGF1R0.34098856
94TNIK0.33237988
95PRKCE0.32639452
96CAMKK20.31779344
97LYN0.30933890
98KIT0.29805599
99CAMK2A0.29271981
100ERBB30.28441544

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005915.49240793
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005925.38936340
3Sulfur relay system_Homo sapiens_hsa041223.30117168
4Ether lipid metabolism_Homo sapiens_hsa005653.10122738
5Chemical carcinogenesis_Homo sapiens_hsa052042.45242062
6Arachidonic acid metabolism_Homo sapiens_hsa005902.40696515
7Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.23759815
8Nitrogen metabolism_Homo sapiens_hsa009102.11170396
9Phototransduction_Homo sapiens_hsa047441.99597262
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84736894
11Nicotine addiction_Homo sapiens_hsa050331.76506896
12Histidine metabolism_Homo sapiens_hsa003401.74762516
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71814817
14Allograft rejection_Homo sapiens_hsa053301.70291758
15Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.69542730
16Autoimmune thyroid disease_Homo sapiens_hsa053201.68502242
17Phenylalanine metabolism_Homo sapiens_hsa003601.65210891
18Graft-versus-host disease_Homo sapiens_hsa053321.60424198
19mRNA surveillance pathway_Homo sapiens_hsa030151.60126422
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56485217
21Type I diabetes mellitus_Homo sapiens_hsa049401.56351217
22Glycerophospholipid metabolism_Homo sapiens_hsa005641.51787694
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46488718
24beta-Alanine metabolism_Homo sapiens_hsa004101.45093893
25Collecting duct acid secretion_Homo sapiens_hsa049661.42339460
26Caffeine metabolism_Homo sapiens_hsa002321.25505148
27Tyrosine metabolism_Homo sapiens_hsa003501.23676814
28Huntingtons disease_Homo sapiens_hsa050161.17445978
29Regulation of autophagy_Homo sapiens_hsa041401.15502470
30Taste transduction_Homo sapiens_hsa047421.13335734
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.03956016
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.03385370
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.03029657
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01314380
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01233023
36Circadian rhythm_Homo sapiens_hsa047100.99044536
37ABC transporters_Homo sapiens_hsa020100.97928976
38Retinol metabolism_Homo sapiens_hsa008300.92510802
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89901026
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88951265
41Synaptic vesicle cycle_Homo sapiens_hsa047210.88820386
42Dorso-ventral axis formation_Homo sapiens_hsa043200.88013314
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87233745
44Salivary secretion_Homo sapiens_hsa049700.85224777
45Olfactory transduction_Homo sapiens_hsa047400.85186916
46Morphine addiction_Homo sapiens_hsa050320.84415926
47Viral myocarditis_Homo sapiens_hsa054160.75429492
48Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.73493939
49Leukocyte transendothelial migration_Homo sapiens_hsa046700.73434758
50Cocaine addiction_Homo sapiens_hsa050300.72897230
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.72782818
52Serotonergic synapse_Homo sapiens_hsa047260.72571844
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71742734
54GABAergic synapse_Homo sapiens_hsa047270.69912803
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.68056894
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67365705
57Amphetamine addiction_Homo sapiens_hsa050310.67205690
58Primary immunodeficiency_Homo sapiens_hsa053400.62873537
59Ras signaling pathway_Homo sapiens_hsa040140.61589874
60Circadian entrainment_Homo sapiens_hsa047130.61055898
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60547671
62Insulin secretion_Homo sapiens_hsa049110.60211328
63Rheumatoid arthritis_Homo sapiens_hsa053230.59114558
64Glutamatergic synapse_Homo sapiens_hsa047240.58766519
65Antigen processing and presentation_Homo sapiens_hsa046120.58701653
66Hepatitis C_Homo sapiens_hsa051600.57935489
67Hematopoietic cell lineage_Homo sapiens_hsa046400.55376140
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.54229327
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52884801
70Peroxisome_Homo sapiens_hsa041460.51771401
71Sphingolipid metabolism_Homo sapiens_hsa006000.50289720
72Calcium signaling pathway_Homo sapiens_hsa040200.49148408
73Asthma_Homo sapiens_hsa053100.48687519
74Choline metabolism in cancer_Homo sapiens_hsa052310.46710739
75Tight junction_Homo sapiens_hsa045300.46517748
76Glutathione metabolism_Homo sapiens_hsa004800.45686219
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44779442
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.43471367
79Butanoate metabolism_Homo sapiens_hsa006500.43304905
80Dopaminergic synapse_Homo sapiens_hsa047280.40655805
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40322048
82cAMP signaling pathway_Homo sapiens_hsa040240.39722026
83Cholinergic synapse_Homo sapiens_hsa047250.39309822
84Hedgehog signaling pathway_Homo sapiens_hsa043400.38491554
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34298570
86Oxytocin signaling pathway_Homo sapiens_hsa049210.33591482
87Notch signaling pathway_Homo sapiens_hsa043300.33159536
88Tryptophan metabolism_Homo sapiens_hsa003800.32643022
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32574772
90Sulfur metabolism_Homo sapiens_hsa009200.31565561
91Oxidative phosphorylation_Homo sapiens_hsa001900.29004345
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28858373
93RNA polymerase_Homo sapiens_hsa030200.28132937
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27519294
95Phagosome_Homo sapiens_hsa041450.27425628
96Influenza A_Homo sapiens_hsa051640.26420298
97Propanoate metabolism_Homo sapiens_hsa006400.26135235
98T cell receptor signaling pathway_Homo sapiens_hsa046600.25138786
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23795664
100GnRH signaling pathway_Homo sapiens_hsa049120.23300379

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