RABIF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1deoxyribonucleoside monophosphate metabolic process (GO:0009162)7.28119500
2mitochondrial DNA replication (GO:0006264)5.86827582
3cullin deneddylation (GO:0010388)5.25719822
4rRNA modification (GO:0000154)5.17123181
5chaperone-mediated protein transport (GO:0072321)5.04601987
6protein deneddylation (GO:0000338)4.99415060
7protein neddylation (GO:0045116)4.83758310
8rRNA methylation (GO:0031167)4.81767523
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.75838700
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.60230073
11pyrimidine-containing compound salvage (GO:0008655)4.59717849
12pyrimidine nucleoside salvage (GO:0043097)4.59717849
13nucleobase biosynthetic process (GO:0046112)4.47790585
14mitochondrial DNA metabolic process (GO:0032042)4.47782958
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.26255180
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.26255180
17NADH dehydrogenase complex assembly (GO:0010257)4.26255180
18nucleoside salvage (GO:0043174)4.23367942
19proteasome assembly (GO:0043248)4.20973183
20ATP synthesis coupled proton transport (GO:0015986)4.11867163
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11867163
22respiratory electron transport chain (GO:0022904)4.02547808
23electron transport chain (GO:0022900)3.97696148
24platelet dense granule organization (GO:0060155)3.95420399
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.93003953
26protein-cofactor linkage (GO:0018065)3.92391880
27mitochondrial respiratory chain complex assembly (GO:0033108)3.89730800
28protein targeting to mitochondrion (GO:0006626)3.82653493
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.80165890
30tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.80165890
31regulation of nuclear cell cycle DNA replication (GO:0033262)3.79691577
32ribosome biogenesis (GO:0042254)3.78468041
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.77924363
34termination of RNA polymerase III transcription (GO:0006386)3.77924363
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.76781689
36establishment of integrated proviral latency (GO:0075713)3.75626786
37snRNA processing (GO:0016180)3.72297647
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.70375482
39DNA strand elongation involved in DNA replication (GO:0006271)3.67847947
40iron-sulfur cluster assembly (GO:0016226)3.67625670
41metallo-sulfur cluster assembly (GO:0031163)3.67625670
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.66798275
43pyrimidine nucleoside biosynthetic process (GO:0046134)3.64207550
44protein localization to mitochondrion (GO:0070585)3.64151685
45telomere maintenance via semi-conservative replication (GO:0032201)3.63930181
46deoxyribonucleotide metabolic process (GO:0009262)3.61625560
47negative regulation of ligase activity (GO:0051352)3.57823474
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57823474
49DNA deamination (GO:0045006)3.56772603
50snRNA metabolic process (GO:0016073)3.55016674
51establishment of protein localization to mitochondrion (GO:0072655)3.53072782
52DNA-dependent DNA replication (GO:0006261)3.50863403
53mannosylation (GO:0097502)3.45478590
54pyrimidine-containing compound biosynthetic process (GO:0072528)3.45242009
55purine nucleobase biosynthetic process (GO:0009113)3.42879419
56DNA strand elongation (GO:0022616)3.42626109
57positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.40143832
58IMP biosynthetic process (GO:0006188)3.39422365
59respiratory chain complex IV assembly (GO:0008535)3.34908298
60RNA methylation (GO:0001510)3.34250351
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.33125133
62peptidyl-histidine modification (GO:0018202)3.31030297
63viral mRNA export from host cell nucleus (GO:0046784)3.29365747
647-methylguanosine mRNA capping (GO:0006370)3.27726123
65regulation of cellular amino acid metabolic process (GO:0006521)3.27380143
66signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.27082269
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.27082269
68ribosome assembly (GO:0042255)3.26701124
69spliceosomal snRNP assembly (GO:0000387)3.25270662
70pyrimidine nucleotide catabolic process (GO:0006244)3.25048136
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23809831
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23809831
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23809831
74formation of translation preinitiation complex (GO:0001731)3.23509361
75positive regulation of ligase activity (GO:0051351)3.23224781
76DNA catabolic process, exonucleolytic (GO:0000738)3.20205947
77ribonucleoprotein complex biogenesis (GO:0022613)3.20082270
78ribosomal small subunit assembly (GO:0000028)3.19645106
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17827758
80peptidyl-arginine omega-N-methylation (GO:0035247)3.17119467
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.17104250
82signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17104250
83DNA replication initiation (GO:0006270)3.16493540
847-methylguanosine RNA capping (GO:0009452)3.15634825
85RNA capping (GO:0036260)3.15634825
86pseudouridine synthesis (GO:0001522)3.15402798
87rRNA processing (GO:0006364)3.15312038
88DNA replication checkpoint (GO:0000076)3.15224005
89base-excision repair, AP site formation (GO:0006285)3.15164487
90regulation of cellular amine metabolic process (GO:0033238)3.13284720
91telomere maintenance via recombination (GO:0000722)3.13065073
92DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.11752315
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.10362699
94signal transduction involved in cell cycle checkpoint (GO:0072395)3.09850633
95Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09557637
96quinone biosynthetic process (GO:1901663)3.08081464
97ubiquinone biosynthetic process (GO:0006744)3.08081464
98pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.07714023
99DNA double-strand break processing (GO:0000729)3.07633178
100mitotic metaphase plate congression (GO:0007080)3.07366571
101establishment of viral latency (GO:0019043)3.06889868
102nucleobase-containing small molecule interconversion (GO:0015949)3.04970810
103deoxyribose phosphate biosynthetic process (GO:0046385)3.04104763
1042-deoxyribonucleotide biosynthetic process (GO:0009265)3.04104763
105transcription-coupled nucleotide-excision repair (GO:0006283)3.03358945
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.02668763
107C-terminal protein lipidation (GO:0006501)3.02051199
108nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01856541
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.01000841
110maturation of SSU-rRNA (GO:0030490)3.00771419
111telomere maintenance via telomere lengthening (GO:0010833)3.00639329
112histone mRNA metabolic process (GO:0008334)3.00036353
113intracellular protein transmembrane import (GO:0044743)2.99627117
114cellular component biogenesis (GO:0044085)2.99469241
115regulation of ubiquitin-protein transferase activity (GO:0051438)2.98658606
116rRNA metabolic process (GO:0016072)2.98582326
117cytochrome complex assembly (GO:0017004)2.97919580
118cytidine deamination (GO:0009972)2.97834016
119cytidine metabolic process (GO:0046087)2.97834016
120cytidine catabolic process (GO:0006216)2.97834016
121tRNA processing (GO:0008033)2.97519047
122spliceosomal complex assembly (GO:0000245)2.95111522
123antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.95084579
124IMP metabolic process (GO:0046040)2.95068551
125deoxyribonucleotide biosynthetic process (GO:0009263)2.95061397
126regulation of mitochondrial translation (GO:0070129)2.94565687
127cell cycle G1/S phase transition (GO:0044843)2.94495104
128G1/S transition of mitotic cell cycle (GO:0000082)2.94495104
129maturation of 5.8S rRNA (GO:0000460)2.92731096
130histone arginine methylation (GO:0034969)2.91199284
131CENP-A containing nucleosome assembly (GO:0034080)2.91198965
132dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.91198785
133preassembly of GPI anchor in ER membrane (GO:0016254)2.90684971
134DNA replication-independent nucleosome organization (GO:0034724)2.87949786
135DNA replication-independent nucleosome assembly (GO:0006336)2.87949786
136negative regulation of dendrite development (GO:2000171)2.87809043
137positive regulation of cell cycle arrest (GO:0071158)2.87512297
138regulation of ligase activity (GO:0051340)2.86250225
139establishment of protein localization to mitochondrial membrane (GO:0090151)2.85793390
140ubiquinone metabolic process (GO:0006743)2.85159236
141transcription elongation from RNA polymerase I promoter (GO:0006362)2.84355141
142protein complex biogenesis (GO:0070271)2.83870125
143organelle disassembly (GO:1903008)2.83454246
144negative regulation of protein ubiquitination (GO:0031397)2.80769602
145regulation of cilium movement (GO:0003352)2.80081324
146protein polyglutamylation (GO:0018095)2.76889254
147ribonucleoprotein complex disassembly (GO:0032988)2.76560402
148sequestering of actin monomers (GO:0042989)2.75271153
149protein K6-linked ubiquitination (GO:0085020)2.70996914
150actin nucleation (GO:0045010)2.69836598
151signal transduction in response to DNA damage (GO:0042770)2.69554582
152amino acid salvage (GO:0043102)2.68913056
153L-methionine salvage (GO:0071267)2.68913056
154L-methionine biosynthetic process (GO:0071265)2.68913056
155hydrogen ion transmembrane transport (GO:1902600)2.68068702
156inner mitochondrial membrane organization (GO:0007007)2.66278376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.66005834
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47346225
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.18913874
4GABP_17652178_ChIP-ChIP_JURKAT_Human4.07925925
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.93848251
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.81530388
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78975248
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69115348
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.47026009
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.40594369
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.32971053
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06961920
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97618824
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.85003340
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82729660
16VDR_23849224_ChIP-Seq_CD4+_Human2.75675922
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69628756
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68998179
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67073404
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.54409665
21DCP1A_22483619_ChIP-Seq_HELA_Human2.50601524
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49146284
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34991176
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33833226
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.30797126
26FOXP3_21729870_ChIP-Seq_TREG_Human2.29072942
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22532492
28ELK1_19687146_ChIP-ChIP_HELA_Human2.21192840
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20199282
30XRN2_22483619_ChIP-Seq_HELA_Human2.18860237
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.17541977
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14581285
33ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11140761
34* SRF_21415370_ChIP-Seq_HL-1_Mouse2.10333910
35* GABP_19822575_ChIP-Seq_HepG2_Human2.03277494
36* CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.01857685
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99837099
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99203499
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96455105
40ZNF274_21170338_ChIP-Seq_K562_Hela1.93573869
41FOXM1_23109430_ChIP-Seq_U2OS_Human1.92097782
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.86811572
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86603379
44TTF2_22483619_ChIP-Seq_HELA_Human1.85667207
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.85481557
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85208548
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.80239191
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74919486
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.73948536
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70429592
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63932770
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55931038
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.55595425
54CIITA_25753668_ChIP-Seq_RAJI_Human1.44514653
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.44345347
56* E2F1_21310950_ChIP-Seq_MCF-7_Human1.41233096
57* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37185555
58VDR_22108803_ChIP-Seq_LS180_Human1.33422689
59* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.30423750
60* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30015323
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29258460
62ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26272381
63KDM5A_27292631_Chip-Seq_BREAST_Human1.25750969
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24627353
65AR_21909140_ChIP-Seq_LNCAP_Human1.19117146
66EWS_26573619_Chip-Seq_HEK293_Human1.18110680
67MYC_18940864_ChIP-ChIP_HL60_Human1.17642233
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14189018
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.13419123
70TP53_22573176_ChIP-Seq_HFKS_Human1.12823744
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.11683594
72* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10866958
73* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10388618
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08890442
75IRF1_19129219_ChIP-ChIP_H3396_Human1.08324696
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05998896
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05632443
78SPI1_23547873_ChIP-Seq_NB4_Human1.05138178
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02483424
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00428191
81* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99528226
82TFEB_21752829_ChIP-Seq_HELA_Human0.96557688
83* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96003002
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95772620
85MYC_22102868_ChIP-Seq_BL_Human0.95070706
86* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94601787
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94035141
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.93230644
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92319008
90* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92191919
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91479901
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91163750
93* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90920271
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90638383
95ELF5_23300383_ChIP-Seq_T47D_Human0.90507676
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89720969
97EGR1_19374776_ChIP-ChIP_THP-1_Human0.87812394
98IGF1R_20145208_ChIP-Seq_DFB_Human0.85947508
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.85149382
100AR_20517297_ChIP-Seq_VCAP_Human0.85089285
101* SALL4_22934838_ChIP-ChIP_CD34+_Human0.84784477
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.84177161
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84035898
104EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83668248
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83428614
106* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82837970
107TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81540483
108GATA3_26560356_Chip-Seq_TH2_Human0.81500999
109TAF15_26573619_Chip-Seq_HEK293_Human0.81178997
110NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80224531
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79901575
112* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79580202
113IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78588323
114RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.75691476
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.72856857
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.72702877
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.71608688
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.71608688
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71176070
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.70358025
121CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.69027057
122NANOG_16153702_ChIP-ChIP_HESCs_Human0.68621017
123GATA3_21878914_ChIP-Seq_MCF-7_Human0.68523873
124NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.65263001
125OCT4_18692474_ChIP-Seq_MEFs_Mouse0.63642303
126* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.63611088
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62404769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.34487740
2MP0004957_abnormal_blastocyst_morpholog4.16057869
3MP0000372_irregular_coat_pigmentation3.92723194
4MP0010094_abnormal_chromosome_stability3.53938044
5MP0008057_abnormal_DNA_replication3.05886657
6MP0003111_abnormal_nucleus_morphology2.76370078
7MP0003077_abnormal_cell_cycle2.74303603
8MP0008058_abnormal_DNA_repair2.73079573
9MP0008877_abnormal_DNA_methylation2.71989505
10MP0006035_abnormal_mitochondrial_morpho2.71740499
11MP0006036_abnormal_mitochondrial_physio2.54306557
12MP0008932_abnormal_embryonic_tissue2.50691632
13MP0002132_abnormal_respiratory_system2.43827632
14MP0008007_abnormal_cellular_replicative2.43342153
15MP0002396_abnormal_hematopoietic_system2.32587014
16MP0003950_abnormal_plasma_membrane2.23083632
17MP0003787_abnormal_imprinting2.20749606
18MP0003123_paternal_imprinting2.15373897
19MP0009333_abnormal_splenocyte_physiolog2.11910606
20MP0002736_abnormal_nociception_after2.07534581
21MP0003806_abnormal_nucleotide_metabolis2.01987975
22MP0003786_premature_aging1.98995970
23MP0002102_abnormal_ear_morphology1.97764414
24MP0006082_CNS_inflammation1.97543158
25MP0001986_abnormal_taste_sensitivity1.97375984
26MP0010030_abnormal_orbit_morphology1.96588591
27MP0002735_abnormal_chemical_nociception1.95707239
28MP0005075_abnormal_melanosome_morpholog1.89767150
29MP0001188_hyperpigmentation1.84795634
30MP0005671_abnormal_response_to1.80269612
31MP0003011_delayed_dark_adaptation1.79275701
32MP0006292_abnormal_olfactory_placode1.74687017
33MP0000350_abnormal_cell_proliferation1.72279685
34MP0001529_abnormal_vocalization1.71448285
35MP0009697_abnormal_copulation1.71168279
36MP0002095_abnormal_skin_pigmentation1.69371689
37MP0008789_abnormal_olfactory_epithelium1.66484181
38MP0000015_abnormal_ear_pigmentation1.64672368
39MP0002148_abnormal_hypersensitivity_rea1.63127652
40MP0001968_abnormal_touch/_nociception1.63011264
41MP0006054_spinal_hemorrhage1.62413481
42MP0003718_maternal_effect1.62277096
43MP0001542_abnormal_bone_strength1.60419039
44MP0003121_genomic_imprinting1.57452388
45MP0008260_abnormal_autophagy1.52762828
46MP0003724_increased_susceptibility_to1.48933273
47MP0005174_abnormal_tail_pigmentation1.47995396
48MP0005410_abnormal_fertilization1.41935334
49MP0004147_increased_porphyrin_level1.41876780
50MP0005408_hypopigmentation1.39945694
51MP0000516_abnormal_urinary_system1.39934006
52MP0005367_renal/urinary_system_phenotyp1.39934006
53MP0009785_altered_susceptibility_to1.38876230
54MP0002876_abnormal_thyroid_physiology1.38383113
55MP0005248_abnormal_Harderian_gland1.35210941
56MP0003763_abnormal_thymus_physiology1.33812320
57MP0005464_abnormal_platelet_physiology1.33212009
58MP0003656_abnormal_erythrocyte_physiolo1.28698524
59MP0002160_abnormal_reproductive_system1.28017351
60MP0009764_decreased_sensitivity_to1.27654620
61MP0002837_dystrophic_cardiac_calcinosis1.26799108
62MP0001853_heart_inflammation1.26313876
63MP0006072_abnormal_retinal_apoptosis1.25916172
64MP0001905_abnormal_dopamine_level1.20879967
65MP0002938_white_spotting1.19494097
66MP0005646_abnormal_pituitary_gland1.16759403
67MP0009765_abnormal_xenobiotic_induced1.15319898
68MP0002282_abnormal_trachea_morphology1.11621610
69MP0004808_abnormal_hematopoietic_stem1.10429083
70MP0002163_abnormal_gland_morphology1.10164955
71MP0005551_abnormal_eye_electrophysiolog1.08802434
72MP0001730_embryonic_growth_arrest1.08463342
73MP0001919_abnormal_reproductive_system1.08431791
74MP0005389_reproductive_system_phenotype1.07802572
75MP0005379_endocrine/exocrine_gland_phen1.06397280
76MP0002398_abnormal_bone_marrow1.05850377
77MP0008872_abnormal_physiological_respon1.05243500
78MP0002019_abnormal_tumor_incidence1.03227644
79MP0002080_prenatal_lethality1.03147213
80MP0002822_catalepsy1.02222670
81MP0001984_abnormal_olfaction1.00098383
82MP0000490_abnormal_crypts_of0.99623621
83MP0005253_abnormal_eye_physiology0.99011674
84MP0002277_abnormal_respiratory_mucosa0.98985212
85MP0001764_abnormal_homeostasis0.98816901
86MP0005499_abnormal_olfactory_system0.98695068
87MP0005394_taste/olfaction_phenotype0.98695068
88MP0000465_gastrointestinal_hemorrhage0.97873972
89MP0002734_abnormal_mechanical_nocicepti0.96947333
90MP0001697_abnormal_embryo_size0.96489170
91MP0002722_abnormal_immune_system0.96204789
92MP0004142_abnormal_muscle_tone0.95286100
93MP0000703_abnormal_thymus_morphology0.94882134
94MP0008875_abnormal_xenobiotic_pharmacok0.94420842
95MP0003186_abnormal_redox_activity0.93777618
96MP0008873_increased_physiological_sensi0.93775135
97MP0000358_abnormal_cell_content/0.93161488
98MP0002933_joint_inflammation0.91336870
99MP0000689_abnormal_spleen_morphology0.90633381
100MP0002723_abnormal_immune_serum0.90574594
101MP0008004_abnormal_stomach_pH0.89187503
102MP0008995_early_reproductive_senescence0.88714544
103MP0005397_hematopoietic_system_phenotyp0.87655325
104MP0001545_abnormal_hematopoietic_system0.87655325
105MP0003567_abnormal_fetal_cardiomyocyte0.87640574
106MP0003632_abnormal_nervous_system0.87412909
107MP0009046_muscle_twitch0.87333965
108MP0000313_abnormal_cell_death0.87210958
109MP0000858_altered_metastatic_potential0.86557000
110MP0005000_abnormal_immune_tolerance0.86462977
111MP0002420_abnormal_adaptive_immunity0.84161822
112MP0000343_altered_response_to0.84143037
113MP0005266_abnormal_metabolism0.82817900
114MP0002751_abnormal_autonomic_nervous0.82114207
115MP0009379_abnormal_foot_pigmentation0.81940505
116MP0000427_abnormal_hair_cycle0.80957712
117MP0002429_abnormal_blood_cell0.80601017
118MP0001819_abnormal_immune_cell0.80253761
119MP0001929_abnormal_gametogenesis0.80056974
120MP0002210_abnormal_sex_determination0.78965411
121MP0010352_gastrointestinal_tract_polyps0.78911030
122MP0001800_abnormal_humoral_immune0.78124682
123MP0001145_abnormal_male_reproductive0.76318824
124MP0010386_abnormal_urinary_bladder0.76062983
125MP0005083_abnormal_biliary_tract0.75990074
126MP0005395_other_phenotype0.75930616
127MP0002452_abnormal_antigen_presenting0.75800068
128MP0000653_abnormal_sex_gland0.73320222
129MP0003646_muscle_fatigue0.72706883
130MP0003195_calcinosis0.71887105
131MP0001835_abnormal_antigen_presentation0.71357547
132MP0001119_abnormal_female_reproductive0.71237022
133MP0001970_abnormal_pain_threshold0.70225519
134MP0000716_abnormal_immune_system0.69111578
135MP0009745_abnormal_behavioral_response0.68198451
136MP0006276_abnormal_autonomic_nervous0.66423710
137MP0005084_abnormal_gallbladder_morpholo0.66386296
138MP0005171_absent_coat_pigmentation0.63065774
139MP0002733_abnormal_thermal_nociception0.61222807
140MP0003122_maternal_imprinting0.59133173
141MP0003436_decreased_susceptibility_to0.59017777
142MP0005384_cellular_phenotype0.59001810
143MP0003880_abnormal_central_pattern0.58540075
144MP0003941_abnormal_skin_development0.56621185
145MP0002272_abnormal_nervous_system0.55856539
146MP0001727_abnormal_embryo_implantation0.55177497

Predicted human phenotypes

RankGene SetZ-score
1Decreased activity of mitochondrial respiratory chain (HP:0008972)6.91420800
2Abnormal activity of mitochondrial respiratory chain (HP:0011922)6.91420800
3Progressive inability to walk (HP:0002505)6.58553141
4Ragged-red muscle fibers (HP:0003200)5.57307384
5Abnormality of the heme biosynthetic pathway (HP:0010472)5.48053516
6Facial diplegia (HP:0001349)5.47889139
7Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.67723185
8Aplastic anemia (HP:0001915)4.43738838
9Irregular epiphyses (HP:0010582)4.08001961
10Inability to walk (HP:0002540)3.95467371
11Delayed gross motor development (HP:0002194)3.62056524
12Abnormality of the anterior horn cell (HP:0006802)3.33994533
13Degeneration of anterior horn cells (HP:0002398)3.33994533
14Cerebral edema (HP:0002181)3.27190905
15Birth length less than 3rd percentile (HP:0003561)3.25363473
16Acute necrotizing encephalopathy (HP:0006965)3.24413214
17Abnormal protein glycosylation (HP:0012346)3.20592310
18Abnormal glycosylation (HP:0012345)3.20592310
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.20592310
20Abnormal protein N-linked glycosylation (HP:0012347)3.20592310
21Abnormal mitochondria in muscle tissue (HP:0008316)3.14807110
22Oral leukoplakia (HP:0002745)3.11375180
23Abnormality of glycolysis (HP:0004366)3.11343893
24Increased serum pyruvate (HP:0003542)3.11343893
25Hepatocellular necrosis (HP:0001404)3.06118586
26Cerebral hypomyelination (HP:0006808)2.98174375
27Pallor (HP:0000980)2.87600483
28Mitochondrial inheritance (HP:0001427)2.87509261
29Rough bone trabeculation (HP:0100670)2.84941224
30Carpal bone hypoplasia (HP:0001498)2.81071842
31Increased hepatocellular lipid droplets (HP:0006565)2.80366798
32Congenital stationary night blindness (HP:0007642)2.79976036
33Abnormality of alanine metabolism (HP:0010916)2.79919525
34Hyperalaninemia (HP:0003348)2.79919525
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.79919525
36Increased CSF lactate (HP:0002490)2.79718388
37Progressive macrocephaly (HP:0004481)2.75640094
38Absent epiphyses (HP:0010577)2.65390412
39Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.65390412
40Lipid accumulation in hepatocytes (HP:0006561)2.63969340
41Increased serum lactate (HP:0002151)2.60964951
42Hypoplasia of the capital femoral epiphysis (HP:0003090)2.59828520
43Abnormal pancreas size (HP:0012094)2.52746542
44Abnormality of cells of the erythroid lineage (HP:0012130)2.51430960
45Lactic acidosis (HP:0003128)2.51267611
46Abnormal number of erythroid precursors (HP:0012131)2.46380207
47Acute encephalopathy (HP:0006846)2.44658757
48Progressive microcephaly (HP:0000253)2.44589288
49Hepatic necrosis (HP:0002605)2.42802408
50Stomatitis (HP:0010280)2.40723353
51Multiple enchondromatosis (HP:0005701)2.38350449
52Annular pancreas (HP:0001734)2.37737578
53Increased IgM level (HP:0003496)2.37535132
54Agnosia (HP:0010524)2.36671959
55Molar tooth sign on MRI (HP:0002419)2.34221857
56Abnormality of midbrain morphology (HP:0002418)2.34221857
57Glossoptosis (HP:0000162)2.33374729
58Adrenal hypoplasia (HP:0000835)2.32926684
59Petechiae (HP:0000967)2.32676729
60Type I transferrin isoform profile (HP:0003642)2.29181025
61Lethargy (HP:0001254)2.28511820
62Exertional dyspnea (HP:0002875)2.27683366
63Abnormality of the labia minora (HP:0012880)2.24785990
64Pancreatic cysts (HP:0001737)2.24745770
65Opisthotonus (HP:0002179)2.23956675
66Reticulocytopenia (HP:0001896)2.23652616
67Severe visual impairment (HP:0001141)2.22442740
68Premature graying of hair (HP:0002216)2.22113311
69Leukodystrophy (HP:0002415)2.21906679
70Hypoplastic pelvis (HP:0008839)2.21861352
71Postnatal microcephaly (HP:0005484)2.21183796
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18090532
73X-linked dominant inheritance (HP:0001423)2.17574295
74Amniotic constriction ring (HP:0009775)2.14720800
75Abnormality of placental membranes (HP:0011409)2.14720800
76Abnormality of the pons (HP:0007361)2.13881786
77Atrophy/Degeneration involving motor neurons (HP:0007373)2.10647059
78Generalized amyotrophy (HP:0003700)2.10420209
79Small hand (HP:0200055)2.09196563
80Generalized aminoaciduria (HP:0002909)2.08676119
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07807764
82Flat capital femoral epiphysis (HP:0003370)2.07591919
83Abnormal trabecular bone morphology (HP:0100671)2.07506765
84Short tibia (HP:0005736)2.06987313
85Breast hypoplasia (HP:0003187)2.06672896
86Poor head control (HP:0002421)2.06466791
87Spinal muscular atrophy (HP:0007269)2.06185308
88Methylmalonic aciduria (HP:0012120)2.05688404
89Aplasia/Hypoplasia involving the musculature (HP:0001460)2.05178824
90Weak cry (HP:0001612)2.04798861
91Small epiphyses (HP:0010585)2.04364168
92Pancreatic fibrosis (HP:0100732)2.03153036
93Aplasia/Hypoplasia of the uvula (HP:0010293)2.02410897
94Bone marrow hypocellularity (HP:0005528)2.02349364
95Tongue fasciculations (HP:0001308)1.99368058
96Parakeratosis (HP:0001036)1.98171181
97Respiratory failure (HP:0002878)1.98103052
98Methylmalonic acidemia (HP:0002912)1.96837195
99Failure to thrive in infancy (HP:0001531)1.96183758
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.96109173
101Abnormal lung lobation (HP:0002101)1.95337913
102Myelodysplasia (HP:0002863)1.94682123
103Abnormal hair whorl (HP:0010721)1.94313734
104CNS demyelination (HP:0007305)1.93711178
105Medial flaring of the eyebrow (HP:0010747)1.93098620
106Abnormality of renal resorption (HP:0011038)1.91345177
107Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90660464
108Retinal dysplasia (HP:0007973)1.89349248
109Chromsome breakage (HP:0040012)1.89135597
110Poor suck (HP:0002033)1.88972626
111Abnormality of the preputium (HP:0100587)1.88674040
112Congenital ichthyosiform erythroderma (HP:0007431)1.88458865
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87749099
114Elevated erythrocyte sedimentation rate (HP:0003565)1.87736929
115Microretrognathia (HP:0000308)1.87299927
116Abnormality of the epiphysis of the femoral head (HP:0010574)1.86099363
117Hypoplasia of the pons (HP:0012110)1.85843622
118Febrile seizures (HP:0002373)1.85231785
119Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.83555013
120Abnormality of femoral epiphyses (HP:0006499)1.83555013
121CNS hypomyelination (HP:0003429)1.83295744
122Tubulointerstitial nephritis (HP:0001970)1.83266382
123Unsteady gait (HP:0002317)1.83028020
124True hermaphroditism (HP:0010459)1.82820908
125Emotional lability (HP:0000712)1.82397362
126Septate vagina (HP:0001153)1.80851319
127Cleft eyelid (HP:0000625)1.80467265
128Increased intramyocellular lipid droplets (HP:0012240)1.80207706
129Exercise intolerance (HP:0003546)1.79313202
130Small intestinal stenosis (HP:0012848)1.78949427
131Duodenal stenosis (HP:0100867)1.78949427
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.78284155
133Blindness (HP:0000618)1.77149176
134Hypothermia (HP:0002045)1.76684656
135IgG deficiency (HP:0004315)1.76589113
136Aplasia/Hypoplasia of the tongue (HP:0010295)1.76570735
137Optic disc pallor (HP:0000543)1.75461209
138Aplasia/hypoplasia of the uterus (HP:0008684)1.75182611
139Reduced antithrombin III activity (HP:0001976)1.74827920
140Abnormal rod and cone electroretinograms (HP:0008323)1.74613792
141Pancytopenia (HP:0001876)1.73307981
1423-Methylglutaconic aciduria (HP:0003535)1.73243719
143Trismus (HP:0000211)1.72996333
144Sparse eyelashes (HP:0000653)1.72807768
145Abnormality of the femoral head (HP:0003368)1.72676242
146Pulmonary fibrosis (HP:0002206)1.70111544
147Meckel diverticulum (HP:0002245)1.69606109
148Abnormality of the basal ganglia (HP:0002134)1.68390337
149Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68116246
150Abnormal hemoglobin (HP:0011902)1.67366568
151Mild short stature (HP:0003502)1.67106092
152Hyperglycinemia (HP:0002154)1.66474024
153Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65356125
154Microvesicular hepatic steatosis (HP:0001414)1.64175676
155Renal Fanconi syndrome (HP:0001994)1.64122399
156Amyotrophic lateral sclerosis (HP:0007354)1.63967848
157Respiratory difficulties (HP:0002880)1.63935795
158Type 2 muscle fiber atrophy (HP:0003554)1.63897397
159Abnormal spermatogenesis (HP:0008669)1.63725187
160Pendular nystagmus (HP:0012043)1.63664582
161Genu varum (HP:0002970)1.63355825
162Muscle fibrillation (HP:0010546)1.63272181
163Neuroendocrine neoplasm (HP:0100634)1.61595486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK34.45073509
2MAP3K124.12515557
3BUB13.84214362
4EIF2AK13.19970014
5VRK22.96202827
6TSSK62.87011115
7TRIM282.75266669
8WEE12.70829510
9CCNB12.69436158
10STK162.64969748
11EIF2AK32.56746320
12CASK2.54776046
13BRSK22.44706876
14MAP4K22.42969900
15CDC72.35274501
16NEK12.18324176
17NME22.12994647
18ACVR1B1.99228305
19NUAK11.92149565
20PIM21.77981215
21CAMKK21.70749053
22CDK191.70442471
23CDK81.68389288
24AKT31.68126659
25MKNK21.68088453
26NME11.66982518
27BMPR1B1.62169057
28TESK21.54550465
29DAPK11.53958509
30PLK31.53253704
31PLK21.52640554
32BRAF1.51511642
33SRPK11.48648280
34VRK11.43782227
35MKNK11.42809951
36DYRK1A1.40082917
37BRSK11.38630957
38PLK11.37089647
39LIMK11.32521735
40WNK31.28349093
41MAP3K111.27130245
42BCKDK1.24418397
43MAPKAPK31.23682195
44TESK11.20322048
45MUSK1.19919561
46PLK41.10583989
47MYLK1.06808566
48SIK31.05612244
49ZAK1.05490206
50MAPK131.05109737
51DYRK21.04656994
52CSNK1G11.03091723
53RPS6KB21.01740850
54PDK30.97798353
55PDK40.97798353
56CSNK1A1L0.96946969
57AURKA0.96874438
58TXK0.92753631
59AURKB0.90260413
60TLK10.89882291
61MAP2K70.88342868
62FLT30.87559580
63STK240.85396474
64GRK70.83199139
65ARAF0.83041421
66PBK0.81904005
67CDK70.77396249
68IKBKB0.76589957
69IRAK30.74433972
70TIE10.73184367
71TTK0.72754963
72CHEK20.71556023
73GRK50.69678759
74MAP3K30.69372933
75MST40.69204607
76ATR0.68915277
77STK38L0.68221087
78PDK20.67705075
79TNK20.67208252
80CDK40.67031567
81NEK20.66496930
82PAK40.65946517
83EIF2AK20.65338796
84CSNK1G30.63585432
85MATK0.63456641
86ADRBK20.61843956
87FES0.61076385
88KDR0.59327553
89SCYL20.58170848
90MAPK70.54725141
91FGFR30.53037222
92TAOK20.52486470
93CSNK2A10.51757553
94TEC0.51260263
95LATS20.51036884
96MINK10.49778025
97GRK10.48935094
98CHEK10.48685609
99GRK60.48188366
100CSNK2A20.47833044
101PKN10.47598767
102EPHA20.46614454
103SYK0.46371880
104MARK10.46125301
105PIM10.45540065
106ERBB30.43724357
107MAP3K50.42078956
108PRKCQ0.42067290
109PAK10.40405889
110BCR0.39965231
111DAPK30.39611334
112OXSR10.39547792
113CDK140.38890497
114BMPR20.37971951
115RPS6KA50.36924617
116MAPKAPK50.36400843
117CDK180.35911487
118ABL20.35889248
119FGR0.35867320
120ILK0.35176530
121MAPK120.34725904
122PRKCG0.34407907
123ZAP700.34175152
124CSNK1A10.33610603
125IKBKE0.33244010
126CSNK1G20.32369456
127MARK30.31201205
128ITK0.30103041
129MAP3K40.30071076
130ADRBK10.29537110
131PRKCI0.28393798
132CDK150.27716929
133PASK0.27477272
134DYRK1B0.27205164
135PIK3CA0.27024242

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.28568248
2DNA replication_Homo sapiens_hsa030303.87377037
3RNA polymerase_Homo sapiens_hsa030203.76529543
4Mismatch repair_Homo sapiens_hsa034303.44930497
5Pyrimidine metabolism_Homo sapiens_hsa002403.36302100
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.27557643
7Ribosome_Homo sapiens_hsa030103.06510864
8Base excision repair_Homo sapiens_hsa034102.88976573
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.53084604
10Spliceosome_Homo sapiens_hsa030402.47758686
11Homologous recombination_Homo sapiens_hsa034402.43585458
12Nucleotide excision repair_Homo sapiens_hsa034202.38706362
13RNA transport_Homo sapiens_hsa030132.31512495
14Oxidative phosphorylation_Homo sapiens_hsa001902.25823625
15Cell cycle_Homo sapiens_hsa041102.07247837
16Basal transcription factors_Homo sapiens_hsa030221.92260963
17Parkinsons disease_Homo sapiens_hsa050121.92130369
18Protein export_Homo sapiens_hsa030601.91863851
19RNA degradation_Homo sapiens_hsa030181.80592596
20Non-homologous end-joining_Homo sapiens_hsa034501.74096564
21Collecting duct acid secretion_Homo sapiens_hsa049661.70232408
22Purine metabolism_Homo sapiens_hsa002301.63219425
23Phototransduction_Homo sapiens_hsa047441.58566846
24Steroid biosynthesis_Homo sapiens_hsa001001.57388912
25Huntingtons disease_Homo sapiens_hsa050161.56018050
26Fanconi anemia pathway_Homo sapiens_hsa034601.47974396
27One carbon pool by folate_Homo sapiens_hsa006701.46499766
28Fatty acid elongation_Homo sapiens_hsa000621.46447298
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.43651042
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.42956600
31Selenocompound metabolism_Homo sapiens_hsa004501.42045736
32Sulfur metabolism_Homo sapiens_hsa009201.41155283
33Sulfur relay system_Homo sapiens_hsa041221.38718954
34Synaptic vesicle cycle_Homo sapiens_hsa047211.38121548
35Regulation of autophagy_Homo sapiens_hsa041401.23881276
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22327792
37Vibrio cholerae infection_Homo sapiens_hsa051101.21882371
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20811247
39p53 signaling pathway_Homo sapiens_hsa041151.16686550
40Pentose phosphate pathway_Homo sapiens_hsa000301.15580290
41Alzheimers disease_Homo sapiens_hsa050101.04501950
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04165470
43Epstein-Barr virus infection_Homo sapiens_hsa051691.01552807
44Rheumatoid arthritis_Homo sapiens_hsa053230.95785904
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93699332
46Vitamin B6 metabolism_Homo sapiens_hsa007500.93579022
47Oocyte meiosis_Homo sapiens_hsa041140.90198763
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.89851230
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87008872
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.86745769
51Peroxisome_Homo sapiens_hsa041460.78732925
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77979667
53Legionellosis_Homo sapiens_hsa051340.76673433
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74362422
55Thyroid cancer_Homo sapiens_hsa052160.73301463
56Phagosome_Homo sapiens_hsa041450.72926212
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72898824
58Biosynthesis of amino acids_Homo sapiens_hsa012300.71365397
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69857254
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63408451
61Propanoate metabolism_Homo sapiens_hsa006400.61059868
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61023208
63mRNA surveillance pathway_Homo sapiens_hsa030150.60607402
64Fructose and mannose metabolism_Homo sapiens_hsa000510.60442390
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59507637
66Folate biosynthesis_Homo sapiens_hsa007900.59053246
67Galactose metabolism_Homo sapiens_hsa000520.54884908
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54073832
69Carbon metabolism_Homo sapiens_hsa012000.52425998
70NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51031224
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50297379
72Type I diabetes mellitus_Homo sapiens_hsa049400.48676224
73Metabolic pathways_Homo sapiens_hsa011000.47036290
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.46623507
75Salmonella infection_Homo sapiens_hsa051320.46363268
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43694171
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.43577341
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43270383
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42799669
80Antigen processing and presentation_Homo sapiens_hsa046120.42648871
81Allograft rejection_Homo sapiens_hsa053300.42432440
82Shigellosis_Homo sapiens_hsa051310.41738689
83Primary immunodeficiency_Homo sapiens_hsa053400.41210861
84Pyruvate metabolism_Homo sapiens_hsa006200.40768710
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39436584
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39224107
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38872287
88N-Glycan biosynthesis_Homo sapiens_hsa005100.38350945
89Olfactory transduction_Homo sapiens_hsa047400.37425238
90Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36615453
91Herpes simplex infection_Homo sapiens_hsa051680.36474734
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34950853
93Butanoate metabolism_Homo sapiens_hsa006500.34615234
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33313628
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.33281537
96Viral carcinogenesis_Homo sapiens_hsa052030.27248585
97Caffeine metabolism_Homo sapiens_hsa002320.26910672
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.26774978
99Non-small cell lung cancer_Homo sapiens_hsa052230.26609575
100Cardiac muscle contraction_Homo sapiens_hsa042600.25899898
101Autoimmune thyroid disease_Homo sapiens_hsa053200.25664856
102Chemical carcinogenesis_Homo sapiens_hsa052040.24492447
103HTLV-I infection_Homo sapiens_hsa051660.23336651
104Lysosome_Homo sapiens_hsa041420.21626043
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.21271925
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20840080
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.20417115
108Nicotine addiction_Homo sapiens_hsa050330.19363527
109Linoleic acid metabolism_Homo sapiens_hsa005910.18975502
110Colorectal cancer_Homo sapiens_hsa052100.18405224
111Graft-versus-host disease_Homo sapiens_hsa053320.17331176
112Viral myocarditis_Homo sapiens_hsa054160.16870135
113Other glycan degradation_Homo sapiens_hsa005110.16510703
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15785562
115Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15708490
116Alcoholism_Homo sapiens_hsa050340.15253517
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.15139959
118Glutathione metabolism_Homo sapiens_hsa004800.14905089
119HIF-1 signaling pathway_Homo sapiens_hsa040660.14592060
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14078357
121Hematopoietic cell lineage_Homo sapiens_hsa046400.14066758
122Ether lipid metabolism_Homo sapiens_hsa005650.13910263
123Arachidonic acid metabolism_Homo sapiens_hsa005900.13247677
124Measles_Homo sapiens_hsa051620.11662281
125Sphingolipid metabolism_Homo sapiens_hsa006000.11414522
126Taste transduction_Homo sapiens_hsa047420.06806999
127Systemic lupus erythematosus_Homo sapiens_hsa053220.06073366
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05143777
129Hepatitis B_Homo sapiens_hsa051610.04756804

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