RAB9A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.23202233
2proteasome assembly (GO:0043248)5.12192760
3chaperone-mediated protein transport (GO:0072321)4.99367370
4establishment of protein localization to mitochondrial membrane (GO:0090151)4.43637815
5protein deneddylation (GO:0000338)4.03333991
6ATP synthesis coupled proton transport (GO:0015986)3.96383712
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96383712
8cullin deneddylation (GO:0010388)3.76144795
9ribosomal large subunit biogenesis (GO:0042273)3.62700483
10DNA deamination (GO:0045006)3.54300396
11negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.52391305
12regulation of mitochondrial translation (GO:0070129)3.37626041
13protein targeting to mitochondrion (GO:0006626)3.37570366
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35388662
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29796991
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28307682
17negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28060193
18negative regulation of ligase activity (GO:0051352)3.28060193
19respiratory electron transport chain (GO:0022904)3.23706768
20positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.17203552
21water-soluble vitamin biosynthetic process (GO:0042364)3.17172962
22ribosome assembly (GO:0042255)3.16315287
23DNA replication checkpoint (GO:0000076)3.16075164
24protein localization to mitochondrion (GO:0070585)3.15329390
25ribosomal small subunit biogenesis (GO:0042274)3.14138381
26electron transport chain (GO:0022900)3.11654287
27establishment of protein localization to mitochondrion (GO:0072655)3.10822696
28DNA catabolic process, exonucleolytic (GO:0000738)3.09760080
29anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09506264
30T-helper 1 type immune response (GO:0042088)3.05913633
31folic acid transport (GO:0015884)3.05697941
32SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02832397
33regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.01862696
34cotranslational protein targeting to membrane (GO:0006613)2.99116129
35termination of RNA polymerase III transcription (GO:0006386)2.99115325
36transcription elongation from RNA polymerase III promoter (GO:0006385)2.99115325
37protein targeting to ER (GO:0045047)2.98499571
38negative regulation of telomerase activity (GO:0051974)2.97958235
39platelet dense granule organization (GO:0060155)2.97358034
40CENP-A containing nucleosome assembly (GO:0034080)2.94914261
41positive regulation of endothelial cell apoptotic process (GO:2000353)2.93306637
42regulation of cellular amino acid metabolic process (GO:0006521)2.93295570
43translation (GO:0006412)2.91758123
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.90309993
45establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89647153
46viral transcription (GO:0019083)2.87371726
47purine nucleobase biosynthetic process (GO:0009113)2.85384040
48translational termination (GO:0006415)2.84047350
49mitotic metaphase plate congression (GO:0007080)2.83507258
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82354909
51signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82354909
52signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82354909
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81700537
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81700537
55positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81542052
56necroptotic process (GO:0070266)2.80767805
57protein localization to endoplasmic reticulum (GO:0070972)2.80688480
58folic acid-containing compound biosynthetic process (GO:0009396)2.79227748
59regulation of interferon-alpha production (GO:0032647)2.78397326
60regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.75520888
61negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.74795994
62positive regulation of ligase activity (GO:0051351)2.74510009
63chromatin remodeling at centromere (GO:0031055)2.73222391
64pseudouridine synthesis (GO:0001522)2.71822049
65pteridine-containing compound biosynthetic process (GO:0042559)2.71404084
66signal transduction involved in DNA integrity checkpoint (GO:0072401)2.69882259
67signal transduction involved in DNA damage checkpoint (GO:0072422)2.69882259
68maturation of SSU-rRNA (GO:0030490)2.68409459
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.67023565
70positive regulation of interferon-alpha production (GO:0032727)2.65989457
71regulation of ubiquitin-protein transferase activity (GO:0051438)2.64188370
72establishment of viral latency (GO:0019043)2.62881247
73T cell apoptotic process (GO:0070231)2.62665747
74antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62191329
75signal transduction involved in cell cycle checkpoint (GO:0072395)2.61544615
76rRNA modification (GO:0000154)2.61513093
77regulation of ligase activity (GO:0051340)2.59018767
78serine family amino acid biosynthetic process (GO:0009070)2.58976402
79ribosomal small subunit assembly (GO:0000028)2.57729670
80intracellular pH reduction (GO:0051452)2.57691577
81intracellular protein transmembrane import (GO:0044743)2.54730237
82protein neddylation (GO:0045116)2.54592369
83spliceosomal snRNP assembly (GO:0000387)2.53288514
84mitochondrial respiratory chain complex assembly (GO:0033108)2.53006767
85ribonucleoprotein complex biogenesis (GO:0022613)2.51330910
86mitochondrial transport (GO:0006839)2.50685476
87establishment of integrated proviral latency (GO:0075713)2.49990050
88regulation of mononuclear cell migration (GO:0071675)2.49898382
89protein complex biogenesis (GO:0070271)2.47225930
90translational initiation (GO:0006413)2.46622995
91rRNA processing (GO:0006364)2.45878926
92cellular response to arsenic-containing substance (GO:0071243)2.43318852
93viral life cycle (GO:0019058)2.43267659
94cofactor transport (GO:0051181)2.43206291
95positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.42165341
96lymphocyte apoptotic process (GO:0070227)2.41715197
97formation of translation preinitiation complex (GO:0001731)2.41439813
98negative regulation of protein ubiquitination (GO:0031397)2.41111066
99translational elongation (GO:0006414)2.40393740
100regulation of interferon-beta biosynthetic process (GO:0045357)2.39885961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.47978782
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.14274364
3CREB1_15753290_ChIP-ChIP_HEK293T_Human3.96061651
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.47255160
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.36760631
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.27236259
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25037693
8CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.93850593
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91030441
10ELK1_19687146_ChIP-ChIP_HELA_Human2.82323802
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.77159776
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.59918614
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.58158923
14DCP1A_22483619_ChIP-Seq_HELA_Human2.53679680
15VDR_23849224_ChIP-Seq_CD4+_Human2.51139927
16E2F7_22180533_ChIP-Seq_HELA_Human2.46527279
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46519189
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40439363
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.35095948
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34827354
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.32883106
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31908249
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.30488313
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30324228
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25744121
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15240978
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14707828
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09636136
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02698357
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.02493292
31ZNF263_19887448_ChIP-Seq_K562_Human1.99188683
32HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95851434
33FOXP3_21729870_ChIP-Seq_TREG_Human1.88610864
34XRN2_22483619_ChIP-Seq_HELA_Human1.86489698
35FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81269401
36SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80498158
37TFEB_21752829_ChIP-Seq_HELA_Human1.77734822
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70413639
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69557775
40TTF2_22483619_ChIP-Seq_HELA_Human1.66727546
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63812438
42GABP_19822575_ChIP-Seq_HepG2_Human1.61907013
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59567043
44AR_21909140_ChIP-Seq_LNCAP_Human1.59214758
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.56453858
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52251023
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47904957
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47516559
49IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46051131
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44957815
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43044756
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39501580
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38403166
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32126848
55ELK1_22589737_ChIP-Seq_MCF10A_Human1.31127830
56CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.29119708
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27160016
58ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26624398
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26184763
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24506605
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.23766584
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23182612
63EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19905126
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19663734
65CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15501510
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14542227
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13622746
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.13577690
69IRF8_21731497_ChIP-ChIP_J774_Mouse1.13384245
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.12667825
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07483896
72EWS_26573619_Chip-Seq_HEK293_Human1.06562449
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.05859742
74MYC_18940864_ChIP-ChIP_HL60_Human1.04571276
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03878410
76YY1_21170310_ChIP-Seq_MESCs_Mouse1.00934711
77* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99448390
78KDM5A_27292631_Chip-Seq_BREAST_Human0.94591012
79* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93027650
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92876615
81ELF5_23300383_ChIP-Seq_T47D_Human0.92302423
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91050636
83TRIM28_21343339_ChIP-Seq_HEK293_Human0.90405018
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.90052597
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89634063
86RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.87708114
87POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86208524
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84033309
89EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.82576755
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.81837098
91NANOG_16153702_ChIP-ChIP_HESCs_Human0.80430964
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80190108
93TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79404888
94TP63_17297297_ChIP-ChIP_HaCaT_Human0.79192551
95PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79084162
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78068864
97KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.77927213
98KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.77927213
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.77927213
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.76872256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.37483628
2MP0003806_abnormal_nucleotide_metabolis3.21822889
3MP0003186_abnormal_redox_activity3.20058370
4MP0008058_abnormal_DNA_repair2.77748788
5MP0003693_abnormal_embryo_hatching2.71191897
6MP0002277_abnormal_respiratory_mucosa2.66726952
7MP0003941_abnormal_skin_development2.65657604
8MP0004957_abnormal_blastocyst_morpholog2.59156250
9MP0006082_CNS_inflammation2.45101439
10MP0002653_abnormal_ependyma_morphology2.38955082
11MP0002148_abnormal_hypersensitivity_rea2.30176485
12MP0005171_absent_coat_pigmentation2.27263833
13MP0000372_irregular_coat_pigmentation2.23541549
14MP0002837_dystrophic_cardiac_calcinosis2.11303062
15MP0000343_altered_response_to2.07376564
16MP0008932_abnormal_embryonic_tissue2.07046289
17MP0003011_delayed_dark_adaptation1.92106902
18MP0010094_abnormal_chromosome_stability1.89730993
19MP0005058_abnormal_lysosome_morphology1.88508058
20MP0002254_reproductive_system_inflammat1.87057085
21MP0003111_abnormal_nucleus_morphology1.85754422
22MP0002139_abnormal_hepatobiliary_system1.74567719
23MP0009785_altered_susceptibility_to1.74244969
24MP0003077_abnormal_cell_cycle1.68498456
25MP0006036_abnormal_mitochondrial_physio1.62485372
26MP0005084_abnormal_gallbladder_morpholo1.61371454
27MP0002877_abnormal_melanocyte_morpholog1.61007713
28MP0009764_decreased_sensitivity_to1.60883929
29MP0002234_abnormal_pharynx_morphology1.51246175
30MP0010234_abnormal_vibrissa_follicle1.50018898
31MP0008007_abnormal_cellular_replicative1.49206611
32MP0002095_abnormal_skin_pigmentation1.48223126
33MP0002163_abnormal_gland_morphology1.44612292
34MP0003453_abnormal_keratinocyte_physiol1.43728199
35MP0001853_heart_inflammation1.39182698
36MP0008004_abnormal_stomach_pH1.38315642
37MP0002938_white_spotting1.35321554
38MP0009840_abnormal_foam_cell1.34576379
39MP0001485_abnormal_pinna_reflex1.32293985
40MP0005408_hypopigmentation1.27911468
41MP0003195_calcinosis1.27763761
42MP0003303_peritoneal_inflammation1.25098528
43MP0002090_abnormal_vision1.25042165
44MP0001873_stomach_inflammation1.23819009
45MP0001764_abnormal_homeostasis1.23769638
46MP0001835_abnormal_antigen_presentation1.22118924
47MP0005379_endocrine/exocrine_gland_phen1.19280605
48MP0000685_abnormal_immune_system1.18849317
49MP0001529_abnormal_vocalization1.16953817
50MP0000490_abnormal_crypts_of1.15134346
51MP0010307_abnormal_tumor_latency1.14661873
52MP0006054_spinal_hemorrhage1.14294066
53MP0008260_abnormal_autophagy1.13505578
54MP0002796_impaired_skin_barrier1.13063662
55MP0005501_abnormal_skin_physiology1.12340640
56MP0004782_abnormal_surfactant_physiolog1.11076907
57MP0005671_abnormal_response_to1.10638276
58MP0010030_abnormal_orbit_morphology1.09209499
59MP0000350_abnormal_cell_proliferation1.08420613
60MP0002452_abnormal_antigen_presenting1.07616030
61MP0008873_increased_physiological_sensi1.06046059
62MP0008469_abnormal_protein_level1.05775244
63MP0000358_abnormal_cell_content/1.05182657
64MP0003950_abnormal_plasma_membrane1.02471268
65MP0001881_abnormal_mammary_gland0.98996322
66MP0009333_abnormal_splenocyte_physiolog0.98293879
67MP0002138_abnormal_hepatobiliary_system0.97967673
68MP0008875_abnormal_xenobiotic_pharmacok0.97844791
69MP0003221_abnormal_cardiomyocyte_apopto0.95908133
70MP0001845_abnormal_inflammatory_respons0.95364331
71MP0002332_abnormal_exercise_endurance0.92960467
72MP0002295_abnormal_pulmonary_circulatio0.90912763
73MP0005387_immune_system_phenotype0.90224536
74MP0001790_abnormal_immune_system0.90224536
75MP0005000_abnormal_immune_tolerance0.89201831
76MP0002419_abnormal_innate_immunity0.89148580
77MP0001727_abnormal_embryo_implantation0.89040556
78MP0001800_abnormal_humoral_immune0.88959777
79MP0005174_abnormal_tail_pigmentation0.88626947
80MP0005025_abnormal_response_to0.88310295
81MP0009763_increased_sensitivity_to0.87489862
82MP0008057_abnormal_DNA_replication0.85540136
83MP0010352_gastrointestinal_tract_polyps0.85443542
84MP0003786_premature_aging0.84772525
85MP0000627_abnormal_mammary_gland0.83900946
86MP0005319_abnormal_enzyme/_coenzyme0.83128723
87MP0005310_abnormal_salivary_gland0.82693872
88MP0003448_altered_tumor_morphology0.81590846
89MP0002723_abnormal_immune_serum0.81170284
90MP0000313_abnormal_cell_death0.79215275
91MP0004510_myositis0.79187716
92MP0002177_abnormal_outer_ear0.77135672
93MP0005332_abnormal_amino_acid0.77048954
94MP0003300_gastrointestinal_ulcer0.76843724
95MP0005166_decreased_susceptibility_to0.76148608
96MP0003075_altered_response_to0.76115197
97MP0001177_atelectasis0.74848089
98MP0010386_abnormal_urinary_bladder0.72251739
99MP0005623_abnormal_meninges_morphology0.71966938
100MP0001851_eye_inflammation0.71429283

Predicted human phenotypes

RankGene SetZ-score
1Increased IgM level (HP:0003496)5.07891179
2Decreased activity of mitochondrial respiratory chain (HP:0008972)5.01594133
3Abnormal activity of mitochondrial respiratory chain (HP:0011922)5.01594133
4Autoimmune thrombocytopenia (HP:0001973)4.62086175
5Increased hepatocellular lipid droplets (HP:0006565)4.48045410
6Renal Fanconi syndrome (HP:0001994)4.13675710
7Lipid accumulation in hepatocytes (HP:0006561)4.09633133
8Autoimmune hemolytic anemia (HP:0001890)4.02549098
9Birth length less than 3rd percentile (HP:0003561)3.88598390
10Acute necrotizing encephalopathy (HP:0006965)3.80722870
11Mitochondrial inheritance (HP:0001427)3.61923242
12Abnormal mitochondria in muscle tissue (HP:0008316)3.51960224
13Increased CSF lactate (HP:0002490)3.51160750
14Increased intramyocellular lipid droplets (HP:0012240)3.49653116
15Acute encephalopathy (HP:0006846)3.30285123
16Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.26275079
17Abnormality of glycolipid metabolism (HP:0010969)3.22303035
18Abnormality of liposaccharide metabolism (HP:0010968)3.22303035
19Abnormality of glycosphingolipid metabolism (HP:0004343)3.22303035
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.21996419
21Progressive macrocephaly (HP:0004481)3.19950142
22Respiratory difficulties (HP:0002880)3.16084429
23Vacuolated lymphocytes (HP:0001922)3.15194517
24Exertional dyspnea (HP:0002875)3.14246448
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.94093026
26Increased muscle lipid content (HP:0009058)2.89273085
27Abnormality of renal resorption (HP:0011038)2.84005326
28Cerebral edema (HP:0002181)2.82469647
293-Methylglutaconic aciduria (HP:0003535)2.75091590
30Respiratory failure (HP:0002878)2.71969696
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.67496435
32Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64305394
33Abnormality of T cell physiology (HP:0011840)2.62813741
34Multiple enchondromatosis (HP:0005701)2.61347271
35Nausea (HP:0002018)2.60789663
36Lactic acidosis (HP:0003128)2.57643848
37Lip pit (HP:0100267)2.57080377
38Hepatocellular necrosis (HP:0001404)2.56133960
39Congenital ichthyosiform erythroderma (HP:0007431)2.54025825
40Patchy hypopigmentation of hair (HP:0011365)2.50257949
41Increased serum lactate (HP:0002151)2.49732134
42Hepatic necrosis (HP:0002605)2.48838864
43Oral leukoplakia (HP:0002745)2.43444360
44Macrocytic anemia (HP:0001972)2.42577408
45Type I transferrin isoform profile (HP:0003642)2.41316236
46Parakeratosis (HP:0001036)2.30482096
47Increased serum pyruvate (HP:0003542)2.28601747
48Cutaneous melanoma (HP:0012056)2.26960066
49Degeneration of anterior horn cells (HP:0002398)2.24766611
50Abnormality of the anterior horn cell (HP:0006802)2.24766611
51Exercise intolerance (HP:0003546)2.21526044
52Reduced antithrombin III activity (HP:0001976)2.20744087
53Abnormality of alanine metabolism (HP:0010916)2.19014782
54Hyperalaninemia (HP:0003348)2.19014782
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19014782
56Neutropenia (HP:0001875)2.15824185
57Poor head control (HP:0002421)2.15476464
58Abnormality of serum amino acid levels (HP:0003112)2.09230390
59Lethargy (HP:0001254)2.08416483
60Sparse eyelashes (HP:0000653)2.08263798
61Eosinophilia (HP:0001880)2.08103766
62Symptomatic seizures (HP:0011145)2.04412229
63Steatorrhea (HP:0002570)2.03821570
64Posterior subcapsular cataract (HP:0007787)2.02808451
65Glycosuria (HP:0003076)2.01995794
66Abnormality of urine glucose concentration (HP:0011016)2.01995794
67Abnormality of methionine metabolism (HP:0010901)2.00645312
68Abnormal protein glycosylation (HP:0012346)2.00555901
69Abnormal glycosylation (HP:0012345)2.00555901
70Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00555901
71Abnormal protein N-linked glycosylation (HP:0012347)2.00555901
72Methylmalonic acidemia (HP:0002912)1.99122247
73Aplasia/hypoplasia of the uterus (HP:0008684)1.98970902
74Abnormality of glycolysis (HP:0004366)1.98020646
75Reticulocytopenia (HP:0001896)1.94785380
76X-linked dominant inheritance (HP:0001423)1.94664018
77Abnormality of cells of the erythroid lineage (HP:0012130)1.94336395
78Hypergammaglobulinemia (HP:0010702)1.91896765
79Megaloblastic anemia (HP:0001889)1.91223144
80Hyperglycinemia (HP:0002154)1.91001868
81Basal ganglia calcification (HP:0002135)1.90719266
82Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90598072
83Leukodystrophy (HP:0002415)1.90156258
84Methylmalonic aciduria (HP:0012120)1.88144965
85Axonal loss (HP:0003447)1.87261856
86Aplastic anemia (HP:0001915)1.85688749
87Albinism (HP:0001022)1.84297877
88Abnormal number of erythroid precursors (HP:0012131)1.82633834
89Abnormality of macrophages (HP:0004311)1.81770649
90Abnormality of T cell number (HP:0011839)1.80632341
91CNS demyelination (HP:0007305)1.80000414
92Hyperphosphaturia (HP:0003109)1.79558761
93Ectropion (HP:0000656)1.78967643
94Stenosis of the external auditory canal (HP:0000402)1.78266969
95Abnormality of the basal ganglia (HP:0002134)1.77938647
96Nuclear cataract (HP:0100018)1.73820566
97Hypoplasia of the uterus (HP:0000013)1.73780747
98Neoplasm of head and neck (HP:0012288)1.72772161
99Esophageal neoplasm (HP:0100751)1.72772161
100Microvesicular hepatic steatosis (HP:0001414)1.72756002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.67016204
2BUB13.45563786
3PDK23.44077037
4PBK3.40432150
5MST43.17169875
6NME22.96939054
7STK162.56269825
8EIF2AK32.46378033
9NEK12.31123313
10PIK3CA2.27807640
11WEE12.11066455
12VRK11.95587317
13STK241.94453288
14VRK21.93611118
15MOS1.93518368
16PIM21.88849036
17ARAF1.83313731
18STK38L1.69197030
19TRIM281.66372898
20BMPR21.63211778
21ZAK1.60208253
22MAP3K121.59585322
23GRK71.57856805
24PNCK1.52642258
25WNK31.51860166
26TAF11.46474929
27EIF2AK11.42111211
28TSSK61.40210047
29ACVR1B1.39637737
30SRPK11.37942660
31TTK1.31938057
32PLK31.29424138
33STK101.23839822
34TNIK1.23579167
35IRAK31.22715184
36BCKDK1.12707680
37TESK11.10793252
38BCR1.10542661
39MAPK151.04067524
40TGFBR21.03685577
41STK31.03093074
42BRSK20.95270621
43LIMK10.89793889
44IKBKB0.89399024
45PLK10.87814211
46CSNK1G30.85933535
47ABL20.85455112
48NEK90.82652795
49OXSR10.82401836
50BMPR1B0.79396617
51MKNK10.77954502
52CSNK1G10.77746572
53MAP3K90.76952432
54EIF2AK20.76580207
55CDC70.75762493
56CSNK1G20.75352650
57TAOK20.75014188
58CDK190.74860159
59STK40.74254848
60LATS20.70079307
61PLK40.68167383
62NEK20.66048869
63NUAK10.65721078
64GRK50.64407052
65TBK10.64383929
66TYK20.62304915
67IKBKE0.60477061
68RPS6KA50.60127807
69PAK40.59946520
70PIM10.59089415
71CSNK1A1L0.57950554
72BRAF0.55755873
73ADRBK20.54266350
74DDR20.53750467
75MAPKAPK50.52259276
76MAP4K20.52046473
77CSNK2A10.51223723
78DAPK30.47809500
79CSNK2A20.47062200
80ERBB40.45600983
81AURKA0.43878119
82ERBB30.42451188
83AURKB0.42202722
84FGR0.41892486
85KIT0.41732183
86DYRK30.41730205
87MAP3K50.38500802
88MARK30.37248767
89CCNB10.37240690
90IRAK40.36222890
91SIK30.34180091
92PAK10.33866978
93TESK20.33279399
94CDK30.33054042
95LRRK20.32695172
96CHEK20.30381474
97BRSK10.28116965
98FRK0.26881597
99ILK0.24393048
100MAP3K140.23877756

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.80290031
2Ribosome_Homo sapiens_hsa030103.45278765
3Oxidative phosphorylation_Homo sapiens_hsa001903.22834286
4Protein export_Homo sapiens_hsa030602.88701151
5Parkinsons disease_Homo sapiens_hsa050122.62776475
6Folate biosynthesis_Homo sapiens_hsa007902.46125392
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.27069085
8Mismatch repair_Homo sapiens_hsa034302.14920472
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.97724412
10Caffeine metabolism_Homo sapiens_hsa002321.93369165
11DNA replication_Homo sapiens_hsa030301.87239001
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84607682
13Homologous recombination_Homo sapiens_hsa034401.84169887
14RNA polymerase_Homo sapiens_hsa030201.78831381
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.74481787
16Huntingtons disease_Homo sapiens_hsa050161.70186522
17Allograft rejection_Homo sapiens_hsa053301.60764188
18Sulfur relay system_Homo sapiens_hsa041221.55842641
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55366232
20Alzheimers disease_Homo sapiens_hsa050101.52246057
21Nucleotide excision repair_Homo sapiens_hsa034201.50030334
22Fatty acid elongation_Homo sapiens_hsa000621.42904029
23African trypanosomiasis_Homo sapiens_hsa051431.38036681
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36909939
25Legionellosis_Homo sapiens_hsa051341.36746715
26Sulfur metabolism_Homo sapiens_hsa009201.35429194
27Autoimmune thyroid disease_Homo sapiens_hsa053201.34124611
28Glutathione metabolism_Homo sapiens_hsa004801.29277786
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27949215
30Spliceosome_Homo sapiens_hsa030401.24309282
31Rheumatoid arthritis_Homo sapiens_hsa053231.24297850
32Graft-versus-host disease_Homo sapiens_hsa053321.23756818
33Base excision repair_Homo sapiens_hsa034101.22397784
34Basal transcription factors_Homo sapiens_hsa030221.20950811
35RNA transport_Homo sapiens_hsa030131.20704964
36Type I diabetes mellitus_Homo sapiens_hsa049401.19792937
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19067676
38Vitamin B6 metabolism_Homo sapiens_hsa007501.18178674
39Pyruvate metabolism_Homo sapiens_hsa006201.17542525
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.16392527
41Pyrimidine metabolism_Homo sapiens_hsa002401.12907125
42One carbon pool by folate_Homo sapiens_hsa006701.11881601
43Pentose phosphate pathway_Homo sapiens_hsa000301.10054026
44Propanoate metabolism_Homo sapiens_hsa006401.06067696
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04203538
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03376533
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03083029
48p53 signaling pathway_Homo sapiens_hsa041150.99874366
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96874148
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96418766
51Collecting duct acid secretion_Homo sapiens_hsa049660.93174577
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90753586
53Steroid biosynthesis_Homo sapiens_hsa001000.89755650
54RNA degradation_Homo sapiens_hsa030180.89376143
55Carbon metabolism_Homo sapiens_hsa012000.88929661
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81609774
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81320949
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81267095
59Non-homologous end-joining_Homo sapiens_hsa034500.80341205
60Influenza A_Homo sapiens_hsa051640.78446455
61Herpes simplex infection_Homo sapiens_hsa051680.76156778
62Fanconi anemia pathway_Homo sapiens_hsa034600.75033312
63Systemic lupus erythematosus_Homo sapiens_hsa053220.74694554
64Tryptophan metabolism_Homo sapiens_hsa003800.74388323
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72744382
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.72545051
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.70981713
68Peroxisome_Homo sapiens_hsa041460.70517630
69Lysosome_Homo sapiens_hsa041420.69312950
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68514040
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67334487
72Cell cycle_Homo sapiens_hsa041100.66084258
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64992737
74* Measles_Homo sapiens_hsa051620.63682692
75Asthma_Homo sapiens_hsa053100.61576180
76Purine metabolism_Homo sapiens_hsa002300.59994800
77Epstein-Barr virus infection_Homo sapiens_hsa051690.58672640
78Selenocompound metabolism_Homo sapiens_hsa004500.57851370
79Metabolic pathways_Homo sapiens_hsa011000.56722616
80Malaria_Homo sapiens_hsa051440.54770314
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53040621
82Apoptosis_Homo sapiens_hsa042100.51306065
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51276673
84Galactose metabolism_Homo sapiens_hsa000520.50439243
85Sphingolipid metabolism_Homo sapiens_hsa006000.49006657
86Regulation of autophagy_Homo sapiens_hsa041400.48506324
87Antigen processing and presentation_Homo sapiens_hsa046120.47073777
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46894766
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.46103158
90Biosynthesis of amino acids_Homo sapiens_hsa012300.45458802
91beta-Alanine metabolism_Homo sapiens_hsa004100.43858375
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42722405
93Nitrogen metabolism_Homo sapiens_hsa009100.41935138
94Mineral absorption_Homo sapiens_hsa049780.41275202
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39931674
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.39774624
97Hepatitis B_Homo sapiens_hsa051610.39565824
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.38793037
99Fatty acid degradation_Homo sapiens_hsa000710.38092278
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37701560

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