RAB43P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)5.94607262
2positive regulation by symbiont of host defense response (GO:0052509)5.08896551
3modulation by symbiont of host defense response (GO:0052031)5.08896551
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08896551
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08896551
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.08896551
7modulation by symbiont of host immune response (GO:0052553)5.08896551
8negative regulation of interleukin-12 production (GO:0032695)4.61655311
9positive regulation of immune response to tumor cell (GO:0002839)4.27718628
10regulation of immune response to tumor cell (GO:0002837)4.27718628
11regulation of response to tumor cell (GO:0002834)4.27718628
12positive regulation of response to tumor cell (GO:0002836)4.27718628
13regulation of RIG-I signaling pathway (GO:0039535)4.22464133
14response to host immune response (GO:0052572)3.74982151
15response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.74982151
16detection of molecule of bacterial origin (GO:0032490)3.74620805
17negative regulation of necroptotic process (GO:0060546)3.70251218
18regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.62915715
19pinocytosis (GO:0006907)3.61688780
20macrophage activation involved in immune response (GO:0002281)3.61584425
21regulation of interferon-beta biosynthetic process (GO:0045357)3.60721469
22positive regulation of gamma-delta T cell activation (GO:0046645)3.56785504
23response to peptidoglycan (GO:0032494)3.53738875
24response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.51151828
25response to host (GO:0075136)3.51151828
26response to host defenses (GO:0052200)3.51151828
27amino sugar catabolic process (GO:0046348)3.30161388
28regulation of necroptotic process (GO:0060544)3.26763032
29detection of biotic stimulus (GO:0009595)3.24001868
30myeloid dendritic cell differentiation (GO:0043011)3.15533907
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.12958654
32regulation of cholesterol homeostasis (GO:2000188)3.10465882
33response to muramyl dipeptide (GO:0032495)3.09657417
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.07336242
35positive regulation of NF-kappaB import into nucleus (GO:0042346)3.07108502
36glucosamine-containing compound catabolic process (GO:1901072)3.06115572
37negative thymic T cell selection (GO:0045060)3.04321158
38positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.03796778
39Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97391098
40necroptotic process (GO:0070266)2.93691853
41pyrimidine-containing compound transmembrane transport (GO:0072531)2.90436596
42myeloid dendritic cell activation (GO:0001773)2.90215135
43cellular response to type I interferon (GO:0071357)2.88748773
44type I interferon signaling pathway (GO:0060337)2.88748773
45regulation of interleukin-12 biosynthetic process (GO:0045075)2.87747925
46activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.86718876
47regulation of B cell receptor signaling pathway (GO:0050855)2.86431701
48response to type I interferon (GO:0034340)2.84929138
49positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.84065267
50regulation of T cell tolerance induction (GO:0002664)2.83007282
51negative regulation of fibrinolysis (GO:0051918)2.81596019
52positive regulation of protein homooligomerization (GO:0032464)2.79518846
53positive regulation of humoral immune response (GO:0002922)2.76606298
54oligosaccharide catabolic process (GO:0009313)2.76373562
55negative T cell selection (GO:0043383)2.75595469
56regulation of gamma-delta T cell activation (GO:0046643)2.74707620
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.73684674
58regulation of toll-like receptor signaling pathway (GO:0034121)2.70643435
59tolerance induction (GO:0002507)2.68276298
60negative regulation of T cell mediated immunity (GO:0002710)2.68010960
61protein localization to endosome (GO:0036010)2.67455250
62regulation of dendritic cell antigen processing and presentation (GO:0002604)2.65929459
63regulation of interleukin-12 production (GO:0032655)2.65879603
64regulation of cholesterol storage (GO:0010885)2.64970986
65negative regulation of necrotic cell death (GO:0060547)2.64313756
66negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.64058499
67regulation of response to interferon-gamma (GO:0060330)2.61610757
68activated T cell proliferation (GO:0050798)2.61028495
69response to laminar fluid shear stress (GO:0034616)2.60858671
70regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.57307133
71regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.57163722
72negative regulation of myeloid cell apoptotic process (GO:0033033)2.56842266
73positive regulation of interleukin-10 production (GO:0032733)2.56421661
74antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.56122427
75regulation of metalloenzyme activity (GO:0048552)2.56058263
76regulation of mast cell degranulation (GO:0043304)2.54203280
77autophagic vacuole fusion (GO:0000046)2.53895726
78embryonic process involved in female pregnancy (GO:0060136)2.50596235
79negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50474692
80negative regulation of cell killing (GO:0031342)2.50474692
81detection of external biotic stimulus (GO:0098581)2.50471768
82dendritic cell differentiation (GO:0097028)2.49317055
83regulation of interleukin-17 production (GO:0032660)2.47931813
84regulation of vitamin D biosynthetic process (GO:0060556)2.47008350
85negative regulation of interleukin-17 production (GO:0032700)2.46797224
86regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46446715
87positive regulation of interleukin-17 production (GO:0032740)2.46390577
88programmed necrotic cell death (GO:0097300)2.44510107
89lipopolysaccharide metabolic process (GO:0008653)2.44349791
90negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.44027118
91positive regulation of interferon-alpha production (GO:0032727)2.43628072
92regulation of interferon-alpha production (GO:0032647)2.41211772
93regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.41074878
94T cell apoptotic process (GO:0070231)2.38437110
95response to interleukin-15 (GO:0070672)2.37964861
96positive regulation of triglyceride lipase activity (GO:0061365)2.37406560
97positive regulation of lipoprotein lipase activity (GO:0051006)2.37406560
98T cell proliferation (GO:0042098)2.36804302
99detection of other organism (GO:0098543)2.36566462
100regulation of interleukin-8 biosynthetic process (GO:0045414)2.36300405

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.28323408
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.89047175
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.67594220
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65052378
5STAT4_19710469_ChIP-ChIP_TH1__Mouse2.60589878
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.49532136
7MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40653803
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.40520612
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.39036661
10MYC_22102868_ChIP-Seq_BL_Human2.35505076
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30513602
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25521237
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.24845903
14VDR_21846776_ChIP-Seq_THP-1_Human2.19575564
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.18839670
16MAF_26560356_Chip-Seq_TH1_Human2.01584129
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.97802161
18IRF8_27001747_Chip-Seq_BMDM_Mouse1.92733469
19BP1_19119308_ChIP-ChIP_Hs578T_Human1.87810418
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.87576744
21BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86465686
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86148083
23MYB_26560356_Chip-Seq_TH2_Human1.84746097
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82217974
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.80443767
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.77598037
27RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77569122
28SPI1_23547873_ChIP-Seq_NB4_Human1.76444022
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.73847436
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.69668230
31CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69055505
32GATA1_22025678_ChIP-Seq_K562_Human1.68458218
33FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67616298
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.67216261
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66967674
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.62785359
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.61303232
38MYB_26560356_Chip-Seq_TH1_Human1.59124351
39TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56884077
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.56557226
41VDR_24763502_ChIP-Seq_THP-1_Human1.55040069
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.54418075
43RUNX_20019798_ChIP-Seq_JUKART_Human1.52450157
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.51474134
45MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51307523
46UTX_26944678_Chip-Seq_JUKART_Human1.51028377
47MAF_26560356_Chip-Seq_TH2_Human1.50698385
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.47787354
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47506541
50E2F7_22180533_ChIP-Seq_HELA_Human1.47134804
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.45808754
52SPI1_23127762_ChIP-Seq_K562_Human1.44602751
53SCL_19346495_ChIP-Seq_HPC-7_Human1.43537089
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41602512
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40650159
56TFEB_21752829_ChIP-Seq_HELA_Human1.40607164
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.39876555
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37011301
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.34765111
60TCF7_22412390_ChIP-Seq_EML_Mouse1.34724364
61GATA1_22383799_ChIP-Seq_G1ME_Mouse1.31207744
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.29756076
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29600281
64PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28952018
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27656277
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.27162340
67PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26836053
68HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.26025319
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25883462
70FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23158598
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.22269603
72DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21388688
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.21319736
74ZNF263_19887448_ChIP-Seq_K562_Human1.20238394
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.17764958
76RXR_22158963_ChIP-Seq_LIVER_Mouse1.16078039
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.11815290
78ATF3_27146783_Chip-Seq_COLON_Human1.11631955
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09956298
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09887192
81PU_27001747_Chip-Seq_BMDM_Mouse1.09823798
82SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09377980
83PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06592723
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.04885585
85CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04715803
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04622529
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04499504
88TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04283788
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02720854
90FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01982219
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01338079
92LXR_22292898_ChIP-Seq_THP-1_Human1.00496885
93TP53_22127205_ChIP-Seq_IMR90_Human0.99458103
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98292923
95CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97675552
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97187809
97YY1_21170310_ChIP-Seq_MESCs_Mouse0.96994888
98NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95779186
99CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95501229
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95493769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol3.93899798
2MP0005451_abnormal_body_composition3.27898894
3MP0003303_peritoneal_inflammation3.22847277
4MP0002163_abnormal_gland_morphology3.11643553
5MP0009333_abnormal_splenocyte_physiolog2.73683074
6MP0000685_abnormal_immune_system2.61635820
7MP0009840_abnormal_foam_cell2.61429200
8MP0003724_increased_susceptibility_to2.60150876
9MP0005058_abnormal_lysosome_morphology2.55943255
10MP0003436_decreased_susceptibility_to2.55249681
11MP0006082_CNS_inflammation2.43133501
12MP0005671_abnormal_response_to2.41596872
13MP0001348_abnormal_lacrimal_gland2.37039394
14MP0001835_abnormal_antigen_presentation2.36978178
15MP0005000_abnormal_immune_tolerance2.27124924
16MP0008260_abnormal_autophagy2.26946693
17MP0002419_abnormal_innate_immunity2.18818638
18MP0009785_altered_susceptibility_to2.18325310
19MP0001800_abnormal_humoral_immune2.14524328
20MP0002723_abnormal_immune_serum2.09688900
21MP0002452_abnormal_antigen_presenting2.06329107
22MP0005025_abnormal_response_to2.04959615
23MP0002148_abnormal_hypersensitivity_rea1.98778551
24MP0005387_immune_system_phenotype1.92001317
25MP0001790_abnormal_immune_system1.92001317
26MP0003763_abnormal_thymus_physiology1.90868496
27MP0005310_abnormal_salivary_gland1.84318747
28MP0003183_abnormal_peptide_metabolism1.83544751
29MP0003300_gastrointestinal_ulcer1.81818029
30MP0005379_endocrine/exocrine_gland_phen1.79086625
31MP0001819_abnormal_immune_cell1.79066099
32MP0002420_abnormal_adaptive_immunity1.78585040
33MP0002877_abnormal_melanocyte_morpholog1.73782050
34MP0004947_skin_inflammation1.66376458
35MP0002139_abnormal_hepatobiliary_system1.63075839
36MP0002405_respiratory_system_inflammati1.59373547
37MP0009278_abnormal_bone_marrow1.58512750
38MP0005464_abnormal_platelet_physiology1.54830132
39MP0001533_abnormal_skeleton_physiology1.53636640
40MP0003172_abnormal_lysosome_physiology1.51945966
41MP0002398_abnormal_bone_marrow1.51635164
42MP0002254_reproductive_system_inflammat1.47024537
43MP0001845_abnormal_inflammatory_respons1.45108369
44MP0000716_abnormal_immune_system1.43749269
45MP0001915_intracranial_hemorrhage1.37101457
46MP0000858_altered_metastatic_potential1.36573692
47MP0008469_abnormal_protein_level1.35930642
48MP0002722_abnormal_immune_system1.31239043
49MP0001545_abnormal_hematopoietic_system1.30006192
50MP0005397_hematopoietic_system_phenotyp1.30006192
51MP0002166_altered_tumor_susceptibility1.29387987
52MP0000689_abnormal_spleen_morphology1.27102883
53MP0002429_abnormal_blood_cell1.24706770
54MP0010155_abnormal_intestine_physiology1.23920477
55MP0003075_altered_response_to1.21211852
56MP0000604_amyloidosis1.16399334
57MP0006054_spinal_hemorrhage1.15619283
58MP0003828_pulmonary_edema1.13861315
59MP0005076_abnormal_cell_differentiation1.13359684
60MP0009764_decreased_sensitivity_to1.12325760
61MP0000465_gastrointestinal_hemorrhage1.09388670
62MP0010368_abnormal_lymphatic_system1.07656042
63MP0004185_abnormal_adipocyte_glucose1.07231601
64MP0002006_tumorigenesis1.07159224
65MP0004233_abnormal_muscle_weight1.06563350
66MP0000609_abnormal_liver_physiology1.06447265
67MP0004381_abnormal_hair_follicle1.03927255
68MP0002998_abnormal_bone_remodeling1.03788613
69MP0001346_abnormal_lacrimal_gland1.02114044
70MP0009763_increased_sensitivity_to0.99676318
71MP0001853_heart_inflammation0.97517291
72MP0005360_urolithiasis0.96484805
73MP0005164_abnormal_response_to0.95945640
74MP0008007_abnormal_cellular_replicative0.94781381
75MP0005319_abnormal_enzyme/_coenzyme0.92836842
76MP0004808_abnormal_hematopoietic_stem0.91672530
77MP0003566_abnormal_cell_adhesion0.91060888
78MP0003656_abnormal_erythrocyte_physiolo0.90968676
79MP0000703_abnormal_thymus_morphology0.90353476
80MP0001851_eye_inflammation0.90230575
81MP0005621_abnormal_cell_physiology0.86233433
82MP0010352_gastrointestinal_tract_polyps0.84174836
83MP0008057_abnormal_DNA_replication0.84114110
84MP0002132_abnormal_respiratory_system0.83755764
85MP0003221_abnormal_cardiomyocyte_apopto0.80999333
86MP0009765_abnormal_xenobiotic_induced0.80428084
87MP0003866_abnormal_defecation0.76654032
88MP0001873_stomach_inflammation0.75556366
89MP0002138_abnormal_hepatobiliary_system0.75079593
90MP0005384_cellular_phenotype0.73451486
91MP0002332_abnormal_exercise_endurance0.73356118
92MP0003091_abnormal_cell_migration0.73213994
93MP0000358_abnormal_cell_content/0.73194978
94MP0003195_calcinosis0.72356141
95MP0000343_altered_response_to0.71940340
96MP0010307_abnormal_tumor_latency0.71042491
97MP0008961_abnormal_basal_metabolism0.70518078
98MP0003329_amyloid_beta_deposits0.69386446
99MP0003111_abnormal_nucleus_morphology0.68728959
100MP0005023_abnormal_wound_healing0.67427925

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycosphingolipid metabolism (HP:0004343)4.58886958
2Abnormality of glycolipid metabolism (HP:0010969)4.58886958
3Abnormality of liposaccharide metabolism (HP:0010968)4.58886958
4Retrobulbar optic neuritis (HP:0100654)4.07469163
5Optic neuritis (HP:0100653)4.07469163
6Orchitis (HP:0100796)4.01676654
7Increased IgM level (HP:0003496)3.89453764
8Autoimmune thrombocytopenia (HP:0001973)3.59693114
9Vacuolated lymphocytes (HP:0001922)3.58246487
10J-shaped sella turcica (HP:0002680)3.47051535
11Myositis (HP:0100614)3.29171973
12Mediastinal lymphadenopathy (HP:0100721)3.25456366
13Autoimmune hemolytic anemia (HP:0001890)3.25113872
14Pulmonary infiltrates (HP:0002113)3.21581167
15Abnormality of macrophages (HP:0004311)3.21412592
16Dysostosis multiplex (HP:0000943)3.19271311
17Keratoconjunctivitis (HP:0001096)3.16547665
18Keratoconjunctivitis sicca (HP:0001097)3.13415448
19Arterial thrombosis (HP:0004420)3.02775415
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.01446736
21Vasculitis (HP:0002633)2.88291211
22Abnormality of the lumbar spine (HP:0100712)2.86704644
23Gastrointestinal infarctions (HP:0005244)2.83002291
24Beaking of vertebral bodies (HP:0004568)2.78293480
25Joint swelling (HP:0001386)2.74552648
26Recurrent fungal infections (HP:0002841)2.73796617
27Abnormality of T cell number (HP:0011839)2.69227015
28Anorexia (HP:0002039)2.66260890
29Mucopolysacchariduria (HP:0008155)2.63727251
30Urinary glycosaminoglycan excretion (HP:0003541)2.63727251
31Deep venous thrombosis (HP:0002625)2.60666694
32Recurrent viral infections (HP:0004429)2.60298787
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.57187872
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.57187872
35Abnormality of polysaccharide metabolism (HP:0011012)2.57187872
36Myocardial infarction (HP:0001658)2.55753617
37Thoracic kyphosis (HP:0002942)2.55566014
38Abnormality of T cell physiology (HP:0011840)2.53023867
39Recurrent bacterial skin infections (HP:0005406)2.52687971
40Loss of speech (HP:0002371)2.52555704
41Amaurosis fugax (HP:0100576)2.46647910
42Granulocytopenia (HP:0001913)2.44802454
43Gingival bleeding (HP:0000225)2.44277709
44Urticaria (HP:0001025)2.41192724
45Eczematoid dermatitis (HP:0000976)2.40362885
46Eosinophilia (HP:0001880)2.39912455
47Flat acetabular roof (HP:0003180)2.38797624
48Alopecia of scalp (HP:0002293)2.37110224
49Increased cerebral lipofuscin (HP:0011813)2.36707508
50Slow saccadic eye movements (HP:0000514)2.34950057
51Meningitis (HP:0001287)2.27599097
52Cheilitis (HP:0100825)2.26864868
53Abnormality of T cells (HP:0002843)2.26483559
54Increased serum ferritin (HP:0003281)2.24885933
55Spondylolisthesis (HP:0003302)2.24635953
56Gangrene (HP:0100758)2.24370435
57Abnormality of the thoracic spine (HP:0100711)2.21500322
58Polyneuropathy (HP:0001271)2.21121792
59Nonimmune hydrops fetalis (HP:0001790)2.18775015
60Recurrent abscess formation (HP:0002722)2.17564434
61Keratitis (HP:0000491)2.17412484
62Mitral stenosis (HP:0001718)2.12578435
63Subacute progressive viral hepatitis (HP:0006572)2.11354468
64Chronic mucocutaneous candidiasis (HP:0002728)2.11126494
65Recurrent cutaneous fungal infections (HP:0011370)2.11126494
66Glomerulopathy (HP:0100820)2.10897994
67Increased neuronal autofluorescent lipopigment (HP:0002074)2.10121108
68Leukocytosis (HP:0001974)2.08583522
69Hypergammaglobulinemia (HP:0010702)2.06957432
70Segmental peripheral demyelination/remyelination (HP:0003481)2.05820924
71T lymphocytopenia (HP:0005403)2.04450235
72Encephalitis (HP:0002383)2.03282816
73Abnormality of the pleura (HP:0002103)2.02900050
74Agammaglobulinemia (HP:0004432)2.01513641
75Pustule (HP:0200039)2.01406389
76Recurrent skin infections (HP:0001581)2.00087641
77Progressive muscle weakness (HP:0003323)1.99739515
78Deformed sella turcica (HP:0002681)1.99391312
79Hypochromic anemia (HP:0001931)1.97792439
80Premature skin wrinkling (HP:0100678)1.95710848
81Thrombophlebitis (HP:0004418)1.95587559
82Increased IgE level (HP:0003212)1.95526994
83Flared iliac wings (HP:0002869)1.94309341
84Abnormality of eosinophils (HP:0001879)1.94140439
85Recurrent gram-negative bacterial infections (HP:0005420)1.92770382
86Vertebral compression fractures (HP:0002953)1.90536339
87Obstructive lung disease (HP:0006536)1.89030089
88Chronic obstructive pulmonary disease (HP:0006510)1.89030089
89Hemoptysis (HP:0002105)1.88700590
90Fatigue (HP:0012378)1.87883059
91Epistaxis (HP:0000421)1.86551551
92Prostate neoplasm (HP:0100787)1.86050170
93Broad face (HP:0000283)1.85538152
94Abnormality of the pericardium (HP:0001697)1.84215685
95Cellulitis (HP:0100658)1.83655661
96Anhidrosis (HP:0000970)1.80586453
97Viral hepatitis (HP:0006562)1.79716272
98Thickened calvaria (HP:0002684)1.78866553
99Purpura (HP:0000979)1.76498396
100Pulmonary embolism (HP:0002204)1.75095816

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK44.14368285
2MAP3K143.96645235
3IRAK33.70657369
4MAP2K32.73325443
5PRPF4B2.51494305
6CDK122.50736089
7SCYL22.44283015
8MAP4K12.32717511
9FES2.27809367
10MAP3K132.24241452
11SMG12.15586557
12FGFR42.13106839
13BLK2.00213548
14EPHB11.95731748
15TGFBR21.91993867
16TAOK21.87738943
17MATK1.84512786
18TXK1.84344924
19ERN11.74623640
20TYK21.60815983
21TAOK11.59865600
22TBK11.59670628
23MAP3K31.58562600
24IKBKE1.56792883
25KDR1.45785185
26BCR1.39830334
27JAK31.38867897
28TESK21.38394698
29INSRR1.35919250
30ZAP701.33923408
31ARAF1.28760862
32CSK1.24924786
33IKBKB1.24202808
34CDK41.20477507
35KIT1.20443603
36IRAK11.18373236
37MAP3K11.18267790
38RIPK41.13080562
39MELK1.12356866
40CHUK1.10619946
41PAK41.08303160
42MAP3K81.07040070
43JAK11.03247132
44MAP3K61.02412338
45IRAK21.00812682
46PIM20.99260001
47TRIB30.99130877
48FGFR30.98954568
49CDK60.94505462
50NME20.94433989
51NEK90.87838334
52STK100.84883277
53MAP3K50.84863954
54TAOK30.82410121
55LYN0.81384553
56CSF1R0.80951853
57BRAF0.73955116
58PDK20.73392450
59CLK10.72827909
60MAP3K110.70900677
61HCK0.69888058
62KSR20.69096265
63ICK0.67135857
64BCKDK0.65990847
65PIM10.64386981
66FGR0.62010876
67PBK0.60952885
68VRK20.57883553
69PDPK10.57702491
70MAPKAPK20.57385135
71CDC42BPA0.57171618
72MAP2K20.55042156
73LCK0.54522179
74MAP3K20.53518996
75TTN0.50963607
76MST1R0.50591749
77PDK10.49704728
78BUB10.49683069
79FER0.49432258
80SYK0.48537994
81GRK60.47291846
82PAK20.47102186
83BTK0.45902688
84PRKCQ0.45715761
85MARK30.43285809
86CDK90.43078249
87MAPK110.39959558
88WNK10.39899492
89STK240.39832598
90RAF10.37567669
91JAK20.37479373
92STK40.37024235
93MST40.36795930
94PRKD20.36278108
95MOS0.34607380
96MAP3K40.32577077
97BMPR20.30537072
98FLT30.30166289
99RPS6KL10.29488368
100RPS6KC10.29488368

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.85831828
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.81092869
3Other glycan degradation_Homo sapiens_hsa005112.50187853
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.43929212
5Leishmaniasis_Homo sapiens_hsa051402.42522077
6Legionellosis_Homo sapiens_hsa051342.23632174
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.22671205
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.07667204
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.03697165
10Measles_Homo sapiens_hsa051621.99429618
11Osteoclast differentiation_Homo sapiens_hsa043801.96201574
12Influenza A_Homo sapiens_hsa051641.96161518
13TNF signaling pathway_Homo sapiens_hsa046681.89439361
14B cell receptor signaling pathway_Homo sapiens_hsa046621.87432837
15Malaria_Homo sapiens_hsa051441.81000347
16Toxoplasmosis_Homo sapiens_hsa051451.79499030
17Acute myeloid leukemia_Homo sapiens_hsa052211.78134341
18Shigellosis_Homo sapiens_hsa051311.77850329
19Primary immunodeficiency_Homo sapiens_hsa053401.73649054
20Hepatitis B_Homo sapiens_hsa051611.66481587
21Herpes simplex infection_Homo sapiens_hsa051681.60816278
22Apoptosis_Homo sapiens_hsa042101.59711029
23Tuberculosis_Homo sapiens_hsa051521.55312869
24Lysosome_Homo sapiens_hsa041421.55234198
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50929200
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46678115
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34799022
28Allograft rejection_Homo sapiens_hsa053301.32154151
29Pertussis_Homo sapiens_hsa051331.31698843
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30728713
31Small cell lung cancer_Homo sapiens_hsa052221.28895041
32Non-small cell lung cancer_Homo sapiens_hsa052231.27556040
33N-Glycan biosynthesis_Homo sapiens_hsa005101.26026816
34Staphylococcus aureus infection_Homo sapiens_hsa051501.21796337
35Bladder cancer_Homo sapiens_hsa052191.17146523
36Hepatitis C_Homo sapiens_hsa051601.16773836
37Viral carcinogenesis_Homo sapiens_hsa052031.16654721
38Chronic myeloid leukemia_Homo sapiens_hsa052201.15977535
39T cell receptor signaling pathway_Homo sapiens_hsa046601.15308494
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.13373791
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10452327
42African trypanosomiasis_Homo sapiens_hsa051431.09903172
43Salmonella infection_Homo sapiens_hsa051321.07649539
44Pancreatic cancer_Homo sapiens_hsa052121.06887360
45Graft-versus-host disease_Homo sapiens_hsa053321.04948936
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01777072
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00078823
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97164286
49Complement and coagulation cascades_Homo sapiens_hsa046100.97077277
50Autoimmune thyroid disease_Homo sapiens_hsa053200.95781264
51Epstein-Barr virus infection_Homo sapiens_hsa051690.94465081
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.91128940
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90321786
54Hematopoietic cell lineage_Homo sapiens_hsa046400.87252334
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87165026
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.86223905
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83818765
58Steroid biosynthesis_Homo sapiens_hsa001000.82936179
59Antigen processing and presentation_Homo sapiens_hsa046120.82622926
60Fructose and mannose metabolism_Homo sapiens_hsa000510.82085442
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81376355
62Rheumatoid arthritis_Homo sapiens_hsa053230.78792230
63Chemokine signaling pathway_Homo sapiens_hsa040620.77979989
64HIF-1 signaling pathway_Homo sapiens_hsa040660.73817561
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.71340123
66Prostate cancer_Homo sapiens_hsa052150.70513231
67Fatty acid elongation_Homo sapiens_hsa000620.69567997
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67874410
69p53 signaling pathway_Homo sapiens_hsa041150.66128456
70Pentose phosphate pathway_Homo sapiens_hsa000300.64860379
71Proteasome_Homo sapiens_hsa030500.62491686
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62433304
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62003742
74Galactose metabolism_Homo sapiens_hsa000520.60646313
75Intestinal immune network for IgA production_Homo sapiens_hsa046720.59832015
76Thyroid cancer_Homo sapiens_hsa052160.59172708
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59037275
78Insulin resistance_Homo sapiens_hsa049310.58995425
79HTLV-I infection_Homo sapiens_hsa051660.58352074
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56937387
81Phagosome_Homo sapiens_hsa041450.56331830
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56051726
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55001958
84DNA replication_Homo sapiens_hsa030300.54464844
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53649573
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.53253913
87VEGF signaling pathway_Homo sapiens_hsa043700.52430756
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52332766
89Amoebiasis_Homo sapiens_hsa051460.51963483
90Type I diabetes mellitus_Homo sapiens_hsa049400.51916003
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49673756
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48607553
93Prolactin signaling pathway_Homo sapiens_hsa049170.42425237
94Viral myocarditis_Homo sapiens_hsa054160.42383441
95Endocytosis_Homo sapiens_hsa041440.41819291
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.41557542
97Proteoglycans in cancer_Homo sapiens_hsa052050.41526270
98Prion diseases_Homo sapiens_hsa050200.41415378
99mTOR signaling pathway_Homo sapiens_hsa041500.39704516
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39360121

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