RAB3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* synaptic vesicle exocytosis (GO:0016079)5.53283137
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.51221508
3* regulation of short-term neuronal synaptic plasticity (GO:0048172)5.50808526
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.27336327
5vocalization behavior (GO:0071625)5.26866253
6locomotory exploration behavior (GO:0035641)5.26440477
7* synaptic vesicle maturation (GO:0016188)5.18681474
8* glutamate secretion (GO:0014047)5.12226180
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.08893116
10* regulation of synaptic vesicle exocytosis (GO:2000300)4.91600401
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.86796128
12protein localization to synapse (GO:0035418)4.82490220
13neuronal action potential propagation (GO:0019227)4.80201584
14regulation of glutamate receptor signaling pathway (GO:1900449)4.72858665
15* neurotransmitter secretion (GO:0007269)4.57256326
16neuron cell-cell adhesion (GO:0007158)4.53378475
17* regulation of synaptic vesicle transport (GO:1902803)4.37705502
18exploration behavior (GO:0035640)4.30729312
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.29693898
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.18468219
21L-amino acid import (GO:0043092)4.12189307
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.08547373
23* regulation of neuronal synaptic plasticity (GO:0048168)4.03666956
24synaptic transmission, glutamatergic (GO:0035249)3.99967901
25regulation of synapse structural plasticity (GO:0051823)3.97138127
26layer formation in cerebral cortex (GO:0021819)3.96791042
27positive regulation of dendritic spine development (GO:0060999)3.92956810
28glutamate receptor signaling pathway (GO:0007215)3.92834617
29neuron-neuron synaptic transmission (GO:0007270)3.91718871
30neurotransmitter-gated ion channel clustering (GO:0072578)3.91608591
31potassium ion homeostasis (GO:0055075)3.91058228
32cellular potassium ion homeostasis (GO:0030007)3.87593679
33positive regulation of dendritic spine morphogenesis (GO:0061003)3.86865853
34amino acid import (GO:0043090)3.85034882
35gamma-aminobutyric acid transport (GO:0015812)3.83771704
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78452706
37regulation of synapse maturation (GO:0090128)3.77358300
38* neurotransmitter transport (GO:0006836)3.74448306
39positive regulation of membrane potential (GO:0045838)3.65128199
40neuromuscular process controlling posture (GO:0050884)3.64943952
41potassium ion import (GO:0010107)3.64736938
42proline transport (GO:0015824)3.62773073
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.61645336
44long-term memory (GO:0007616)3.61520290
45positive regulation of synapse maturation (GO:0090129)3.60744986
46synaptic vesicle endocytosis (GO:0048488)3.59152563
47activation of protein kinase A activity (GO:0034199)3.57785790
48cerebellar Purkinje cell differentiation (GO:0021702)3.56836409
49gamma-aminobutyric acid signaling pathway (GO:0007214)3.53151511
50cellular sodium ion homeostasis (GO:0006883)3.52672205
51regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52574768
52establishment of mitochondrion localization (GO:0051654)3.52416035
53sodium ion export (GO:0071436)3.49782179
54dendritic spine organization (GO:0097061)3.49746989
55regulation of postsynaptic membrane potential (GO:0060078)3.48751368
56dendritic spine morphogenesis (GO:0060997)3.48385368
57negative regulation of synaptic transmission, GABAergic (GO:0032229)3.47936763
58* regulation of neurotransmitter levels (GO:0001505)3.45707690
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.45531618
60regulation of dendritic spine development (GO:0060998)3.41528976
61neuron recognition (GO:0008038)3.41308254
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.39794353
63long-term synaptic potentiation (GO:0060291)3.35855489
64* regulation of neurotransmitter secretion (GO:0046928)3.35151467
65* regulation of synaptic plasticity (GO:0048167)3.34501359
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.34332449
67transmission of nerve impulse (GO:0019226)3.33243295
68regulation of ARF protein signal transduction (GO:0032012)3.32662297
69central nervous system myelination (GO:0022010)3.31137599
70axon ensheathment in central nervous system (GO:0032291)3.31137599
71positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29705964
72cell communication by electrical coupling (GO:0010644)3.27569998
73postsynaptic membrane organization (GO:0001941)3.27343009
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23915422
75cerebellar Purkinje cell layer development (GO:0021680)3.23235411
76regulation of synaptic transmission, glutamatergic (GO:0051966)3.21503451
77membrane depolarization during action potential (GO:0086010)3.20054018
78neuromuscular process controlling balance (GO:0050885)3.19403212
79acidic amino acid transport (GO:0015800)3.19143995
80regulation of dendritic spine morphogenesis (GO:0061001)3.17439473
81positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.16478075
82G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.15072858
83auditory behavior (GO:0031223)3.13197835
84* regulation of neurotransmitter transport (GO:0051588)3.12193835
85positive regulation of neurotransmitter transport (GO:0051590)3.11991726
86membrane depolarization (GO:0051899)3.11059982
87membrane hyperpolarization (GO:0060081)3.10709380
88response to auditory stimulus (GO:0010996)3.10404315
89* synaptic vesicle transport (GO:0048489)3.09602190
90* establishment of synaptic vesicle localization (GO:0097480)3.09602190
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09587371
92cell differentiation in hindbrain (GO:0021533)3.09325878
93vesicle docking involved in exocytosis (GO:0006904)3.07277811
94presynaptic membrane assembly (GO:0097105)3.07222550
95innervation (GO:0060384)3.06136421
96vesicle transport along microtubule (GO:0047496)3.04807405
97cell migration in hindbrain (GO:0021535)3.04698299
98cell communication involved in cardiac conduction (GO:0086065)3.04189168
99regulation of voltage-gated calcium channel activity (GO:1901385)3.03767783
100positive regulation of neurotransmitter secretion (GO:0001956)3.03272812
101* synaptic transmission (GO:0007268)3.03149828
102glycine transport (GO:0015816)3.01569523
103prepulse inhibition (GO:0060134)3.01134135
104axonal fasciculation (GO:0007413)3.00797461
105synapse assembly (GO:0007416)2.98944868
106positive regulation of synaptic transmission (GO:0050806)2.97723295
107cerebellar granule cell differentiation (GO:0021707)2.96336855
108mating behavior (GO:0007617)2.95267140
109presynaptic membrane organization (GO:0097090)2.94863685
110learning (GO:0007612)2.93735085
111* regulation of synaptic transmission (GO:0050804)2.93464196
112adult walking behavior (GO:0007628)2.92532460
113neuronal ion channel clustering (GO:0045161)2.92303282
114negative regulation of dendrite morphogenesis (GO:0050774)2.92124216
115* regulation of vesicle fusion (GO:0031338)2.92030920
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.91873695
117dendrite morphogenesis (GO:0048813)2.91702596
118behavioral response to cocaine (GO:0048148)2.89338999
119response to pheromone (GO:0019236)2.89252184
120negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.88943114
121neuromuscular process (GO:0050905)2.88472727
122negative regulation of microtubule polymerization (GO:0031115)2.86503005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00050007
2GBX2_23144817_ChIP-Seq_PC3_Human3.52739566
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23632119
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.14424036
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10586497
6REST_21632747_ChIP-Seq_MESCs_Mouse2.93729393
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.75507898
8* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73898507
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73898507
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.65743859
11SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.63106411
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62349125
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59822508
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54905724
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53360650
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.53042759
17REST_18959480_ChIP-ChIP_MESCs_Mouse2.46272620
18DROSHA_22980978_ChIP-Seq_HELA_Human2.44119182
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.36447852
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.33232414
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.27453576
22CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.26390423
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24672900
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.19594629
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.17114415
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14601741
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.89331948
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87720017
29TAF15_26573619_Chip-Seq_HEK293_Human1.84437892
30* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79960031
31AR_21572438_ChIP-Seq_LNCaP_Human1.79508533
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78160306
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72790276
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63816488
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61316841
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.56896006
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49249860
38* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.44158102
39ZNF274_21170338_ChIP-Seq_K562_Hela1.40824798
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40447486
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38231813
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37945598
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37608543
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37432451
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37016246
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33795201
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33069563
48P300_19829295_ChIP-Seq_ESCs_Human1.32471092
49RING1B_27294783_Chip-Seq_ESCs_Mouse1.30902520
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30247443
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.29806843
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29622001
53AR_25329375_ChIP-Seq_VCAP_Human1.23132490
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.20527844
55OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19982160
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.19290042
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19249158
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18782855
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.17583798
60AR_19668381_ChIP-Seq_PC3_Human1.16678449
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15898046
62STAT3_23295773_ChIP-Seq_U87_Human1.15191797
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14755880
64IGF1R_20145208_ChIP-Seq_DFB_Human1.14195871
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12619694
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12455654
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12260020
68* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10514834
69RNF2_27304074_Chip-Seq_NSC_Mouse1.10240904
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10071161
71* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06748419
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.06059475
73CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04438901
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03744672
75EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.03361543
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.02869090
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.02859036
78* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02373633
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01903941
80TCF4_23295773_ChIP-Seq_U87_Human1.00623722
81KDM2B_26808549_Chip-Seq_K562_Human0.98423754
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97260803
83YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97083184
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96265810
85SMAD3_21741376_ChIP-Seq_ESCs_Human0.95510737
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95492262
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95048455
88OCT4_19829295_ChIP-Seq_ESCs_Human0.94783238
89PRDM14_20953172_ChIP-Seq_ESCs_Human0.94646209
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93643323
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.93611701
92POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92015625
93RUNX2_22187159_ChIP-Seq_PCA_Human0.91439341
94AHR_22903824_ChIP-Seq_MCF-7_Human0.90963735
95VDR_22108803_ChIP-Seq_LS180_Human0.90233075
96UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89993210
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89147190
98* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88415112
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.88406346
100TET1_21490601_ChIP-Seq_MESCs_Mouse0.88009583
101CTCF_27219007_Chip-Seq_Bcells_Human0.87967815
102ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87761401
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86862165
104* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86651132
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86510531
106ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86235998
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86183919
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.85701041
109JUN_21703547_ChIP-Seq_K562_Human0.85455530
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.84782800
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84253949
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.84070761
113GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83245742
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80208631
115SMC4_20622854_ChIP-Seq_HELA_Human0.78944644
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.78730390
117KLF4_19829295_ChIP-Seq_ESCs_Human0.78689547
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78261051
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78001515
120LXR_22292898_ChIP-Seq_THP-1_Human0.76662550
121TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71990513
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71990513
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.70959823
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70774270
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.69572328
126SOX9_26525672_Chip-Seq_HEART_Mouse0.68899275
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.68811219

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07471719
2MP0003880_abnormal_central_pattern4.96906096
3* MP0003635_abnormal_synaptic_transmissio4.05443247
4MP0004270_analgesia3.66380092
5MP0009745_abnormal_behavioral_response3.34736409
6MP0009046_muscle_twitch3.23895763
7MP0002063_abnormal_learning/memory/cond3.21408495
8MP0002064_seizures3.19782767
9MP0001968_abnormal_touch/_nociception3.14701124
10MP0005423_abnormal_somatic_nervous2.76750143
11MP0002734_abnormal_mechanical_nocicepti2.75118611
12MP0002572_abnormal_emotion/affect_behav2.74561245
13MP0002272_abnormal_nervous_system2.72108427
14MP0002736_abnormal_nociception_after2.50625476
15MP0001486_abnormal_startle_reflex2.50259322
16MP0002822_catalepsy2.48415816
17MP0002735_abnormal_chemical_nociception2.43800440
18MP0001501_abnormal_sleep_pattern2.24974011
19MP0002733_abnormal_thermal_nociception2.18702083
20MP0001440_abnormal_grooming_behavior2.16932267
21MP0006276_abnormal_autonomic_nervous2.15802082
22MP0001970_abnormal_pain_threshold2.10491147
23MP0002067_abnormal_sensory_capabilities2.06295586
24MP0008569_lethality_at_weaning1.91729247
25MP0002184_abnormal_innervation1.90626619
26MP0003329_amyloid_beta_deposits1.86756713
27MP0009780_abnormal_chondrocyte_physiolo1.85739255
28MP0002909_abnormal_adrenal_gland1.83567600
29MP0004858_abnormal_nervous_system1.76627551
30MP0001984_abnormal_olfaction1.76350275
31MP0004811_abnormal_neuron_physiology1.76054284
32* MP0002557_abnormal_social/conspecific_i1.68149601
33MP0000778_abnormal_nervous_system1.65659523
34MP0005646_abnormal_pituitary_gland1.64838132
35* MP0005386_behavior/neurological_phenoty1.64528809
36* MP0004924_abnormal_behavior1.64528809
37MP0000955_abnormal_spinal_cord1.59356455
38MP0001529_abnormal_vocalization1.57527418
39MP0003879_abnormal_hair_cell1.57176857
40MP0004142_abnormal_muscle_tone1.52748593
41MP0003122_maternal_imprinting1.49465784
42MP0003123_paternal_imprinting1.48658153
43MP0002882_abnormal_neuron_morphology1.46248704
44MP0002066_abnormal_motor_capabilities/c1.44028084
45MP0001905_abnormal_dopamine_level1.43514587
46MP0003787_abnormal_imprinting1.41496334
47MP0005645_abnormal_hypothalamus_physiol1.34926070
48MP0003633_abnormal_nervous_system1.30944256
49MP0004885_abnormal_endolymph1.29141667
50MP0000751_myopathy1.27263411
51MP0005551_abnormal_eye_electrophysiolog1.22408412
52MP0000013_abnormal_adipose_tissue1.15184557
53MP0002837_dystrophic_cardiac_calcinosis1.14576106
54MP0002229_neurodegeneration1.13358462
55* MP0001502_abnormal_circadian_rhythm1.13015010
56MP0010386_abnormal_urinary_bladder1.12165608
57MP0003631_nervous_system_phenotype1.10513043
58MP0004145_abnormal_muscle_electrophysio1.10006969
59MP0003121_genomic_imprinting1.08446713
60MP0002152_abnormal_brain_morphology1.04406905
61MP0008872_abnormal_physiological_respon1.02728459
62MP0008877_abnormal_DNA_methylation0.97890201
63MP0001188_hyperpigmentation0.96794945
64MP0002069_abnormal_eating/drinking_beha0.94272283
65MP0004742_abnormal_vestibular_system0.92333487
66MP0005535_abnormal_body_temperature0.89820919
67MP0004147_increased_porphyrin_level0.89143920
68MP0003634_abnormal_glial_cell0.89094217
69MP0004085_abnormal_heartbeat0.87053384
70MP0005394_taste/olfaction_phenotype0.85862814
71MP0005499_abnormal_olfactory_system0.85862814
72MP0008874_decreased_physiological_sensi0.85532821
73MP0002752_abnormal_somatic_nervous0.85020662
74MP0001963_abnormal_hearing_physiology0.83283102
75MP0004215_abnormal_myocardial_fiber0.82805144
76MP0001348_abnormal_lacrimal_gland0.82785493
77MP0002090_abnormal_vision0.82073088
78MP0002638_abnormal_pupillary_reflex0.81949355
79MP0000604_amyloidosis0.78647242
80MP0006072_abnormal_retinal_apoptosis0.76926122
81MP0000920_abnormal_myelination0.75962908
82MP0000631_abnormal_neuroendocrine_gland0.75296717
83MP0003632_abnormal_nervous_system0.74987540
84MP0003283_abnormal_digestive_organ0.74963827
85MP0008961_abnormal_basal_metabolism0.73064912
86MP0004233_abnormal_muscle_weight0.72356236
87MP0001177_atelectasis0.72169708
88MP0003137_abnormal_impulse_conducting0.70067416
89MP0004043_abnormal_pH_regulation0.68423567
90MP0001664_abnormal_digestion0.68206251
91MP0002876_abnormal_thyroid_physiology0.67860466
92MP0003690_abnormal_glial_cell0.66714390
93MP0003075_altered_response_to0.63232812
94MP0005167_abnormal_blood-brain_barrier0.63014176
95MP0001346_abnormal_lacrimal_gland0.62462109
96MP0001986_abnormal_taste_sensitivity0.61677178
97MP0004484_altered_response_of0.61662777
98MP0001485_abnormal_pinna_reflex0.61380057
99MP0003861_abnormal_nervous_system0.59384604
100MP0003183_abnormal_peptide_metabolism0.56301562
101MP0005623_abnormal_meninges_morphology0.56176566
102MP0010768_mortality/aging0.55844608
103MP0005253_abnormal_eye_physiology0.55700165
104MP0010770_preweaning_lethality0.55484023
105MP0002082_postnatal_lethality0.55484023
106MP0004130_abnormal_muscle_cell0.55255402
107MP0001299_abnormal_eye_distance/0.55236125
108MP0000026_abnormal_inner_ear0.53266436
109* MP0001943_abnormal_respiration0.53003696
110MP0000747_muscle_weakness0.52949830
111MP0010769_abnormal_survival0.51831163
112MP0002653_abnormal_ependyma_morphology0.51680375
113MP0000569_abnormal_digit_pigmentation0.51416968
114* MP0003956_abnormal_body_size0.50734271
115MP0003938_abnormal_ear_development0.45141051
116* MP0002873_normal_phenotype0.42556285

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.36285718
2Myokymia (HP:0002411)7.05847984
3Focal seizures (HP:0007359)5.57791747
4Visual hallucinations (HP:0002367)5.51381943
5Atonic seizures (HP:0010819)5.02112020
6Epileptic encephalopathy (HP:0200134)4.95966067
7Febrile seizures (HP:0002373)4.65659870
8Progressive cerebellar ataxia (HP:0002073)4.42836726
9Absence seizures (HP:0002121)4.32553771
10Action tremor (HP:0002345)3.91452148
11Dialeptic seizures (HP:0011146)3.89550733
12Generalized tonic-clonic seizures (HP:0002069)3.86136208
13Supranuclear gaze palsy (HP:0000605)3.74311336
14Ankle clonus (HP:0011448)3.50901132
15Cerebral hypomyelination (HP:0006808)3.33844107
16Depression (HP:0000716)3.31612021
17Anxiety (HP:0000739)3.16307169
18Pheochromocytoma (HP:0002666)3.15796736
19Broad-based gait (HP:0002136)3.15426141
20Gaze-evoked nystagmus (HP:0000640)3.09276181
21Impaired vibration sensation in the lower limbs (HP:0002166)3.07750568
22Abnormal eating behavior (HP:0100738)3.06575494
23Dysdiadochokinesis (HP:0002075)3.06107343
24Poor eye contact (HP:0000817)3.05489060
25Truncal ataxia (HP:0002078)3.03768259
26Mutism (HP:0002300)2.99074201
27Dysmetria (HP:0001310)2.97813428
28Tetraplegia (HP:0002445)2.95429207
29Amblyopia (HP:0000646)2.91397503
30Hyperventilation (HP:0002883)2.89920399
31Urinary bladder sphincter dysfunction (HP:0002839)2.88887340
32Obstructive sleep apnea (HP:0002870)2.85769150
33Limb dystonia (HP:0002451)2.85361965
34Sleep apnea (HP:0010535)2.81765768
35Impaired social interactions (HP:0000735)2.80840634
36Abnormal social behavior (HP:0012433)2.80840634
37Postural instability (HP:0002172)2.79859314
38Neuroendocrine neoplasm (HP:0100634)2.77832902
39Progressive inability to walk (HP:0002505)2.70384222
40Urinary urgency (HP:0000012)2.62011893
41Ventricular fibrillation (HP:0001663)2.61629915
42Abnormality of the lower motor neuron (HP:0002366)2.61091192
43Spastic gait (HP:0002064)2.59360336
44Scanning speech (HP:0002168)2.56491233
45Torticollis (HP:0000473)2.55480975
46Epileptiform EEG discharges (HP:0011182)2.54328109
47Peripheral hypomyelination (HP:0007182)2.52378292
48Genetic anticipation (HP:0003743)2.52268679
49Hemiparesis (HP:0001269)2.49055603
50Bradykinesia (HP:0002067)2.48497422
51Apathy (HP:0000741)2.48176893
52EEG with generalized epileptiform discharges (HP:0011198)2.46392484
53Focal dystonia (HP:0004373)2.44412825
54Papilledema (HP:0001085)2.43548245
55Polyphagia (HP:0002591)2.39626823
56Drooling (HP:0002307)2.37937307
57Excessive salivation (HP:0003781)2.37937307
58Impaired smooth pursuit (HP:0007772)2.36442626
59Failure to thrive in infancy (HP:0001531)2.36002200
60Morphological abnormality of the pyramidal tract (HP:0002062)2.35280676
61Insidious onset (HP:0003587)2.34671031
62Termporal pattern (HP:0011008)2.34671031
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.32712150
64Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.32712150
65Hypsarrhythmia (HP:0002521)2.31722510
66Neurofibrillary tangles (HP:0002185)2.30801204
67Cerebral inclusion bodies (HP:0100314)2.29748341
68Hemiplegia (HP:0002301)2.26185141
69Diminished motivation (HP:0000745)2.26012703
70Insomnia (HP:0100785)2.24660505
71CNS hypomyelination (HP:0003429)2.23242903
72Intention tremor (HP:0002080)2.23117289
73Abnormality of binocular vision (HP:0011514)2.23005963
74Diplopia (HP:0000651)2.23005963
75Agitation (HP:0000713)2.22913500
76Fetal akinesia sequence (HP:0001989)2.21340085
77Abnormality of the corticospinal tract (HP:0002492)2.21331456
78Craniofacial dystonia (HP:0012179)2.19239065
79Status epilepticus (HP:0002133)2.18651595
80Spastic tetraparesis (HP:0001285)2.15936803
81Inability to walk (HP:0002540)2.12760655
82Stereotypic behavior (HP:0000733)2.10403634
83Lower limb muscle weakness (HP:0007340)2.10329655
84Spastic tetraplegia (HP:0002510)2.08941479
85Delusions (HP:0000746)2.07695939
86Megalencephaly (HP:0001355)2.07575329
87Hypoventilation (HP:0002791)2.07186737
88Abnormality of ocular smooth pursuit (HP:0000617)2.07111655
89Dysmetric saccades (HP:0000641)2.05661112
90Choreoathetosis (HP:0001266)2.04741085
91Generalized myoclonic seizures (HP:0002123)2.03818900
92Impaired vibratory sensation (HP:0002495)2.01027488
93Absent speech (HP:0001344)1.98491253
94Neoplasm of the peripheral nervous system (HP:0100007)1.98253208
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97497989
96Split foot (HP:0001839)1.97377724
97Gait imbalance (HP:0002141)1.95862099
98Incomplete penetrance (HP:0003829)1.95760666
99Psychosis (HP:0000709)1.95129829
100Hand muscle atrophy (HP:0009130)1.93401878
101Specific learning disability (HP:0001328)1.91563892
102Gait ataxia (HP:0002066)1.90603664
103Annular pancreas (HP:0001734)1.89211645
104Rigidity (HP:0002063)1.87818509
105Central scotoma (HP:0000603)1.87786235
106Clonus (HP:0002169)1.87398721
107Bundle branch block (HP:0011710)1.86526555
108Abnormal EKG (HP:0003115)1.84782658
109Unsteady gait (HP:0002317)1.83265779
110Rapidly progressive (HP:0003678)1.81675000
111Poor suck (HP:0002033)1.79631209
112Lower limb amyotrophy (HP:0007210)1.79495374
113Hypoplasia of the corpus callosum (HP:0002079)1.79266689
114Akinesia (HP:0002304)1.78663116
115Hypercortisolism (HP:0001578)1.78125613
116Resting tremor (HP:0002322)1.78002010
117Retinal dysplasia (HP:0007973)1.77937936
118Neuronal loss in central nervous system (HP:0002529)1.77330023
119Abnormal hair whorl (HP:0010721)1.74620409
120Amyotrophic lateral sclerosis (HP:0007354)1.73646097
121Paraplegia (HP:0010550)1.73421667
122Spinal canal stenosis (HP:0003416)1.71594920
123Distal upper limb amyotrophy (HP:0007149)1.67205422

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.24762758
2MAP3K93.91528177
3EPHA43.65881759
4MAP3K43.05304654
5MINK12.93129662
6MARK12.91118977
7MAP3K122.65763317
8MAP2K72.57575523
9DAPK22.40496765
10PAK62.32987270
11CASK2.18863000
12KSR22.18259003
13MAP2K41.97574087
14ARAF1.89148750
15NTRK21.88914961
16NTRK11.85745997
17PRKD31.74267143
18GRK51.72377304
19CDK191.69633587
20CAMKK11.67955639
21KSR11.56146313
22PLK21.55961242
23RIPK41.54394710
24CDK51.53115336
25DAPK11.52041320
26MAPK131.34792639
27PRPF4B1.31807312
28PNCK1.30969037
29PRKCG1.27501417
30CAMKK21.25705891
31UHMK11.24914844
32STK381.24595275
33PHKG21.24482110
34PHKG11.24482110
35TNIK1.19343079
36MAP3K131.16488029
37MAP3K21.12222757
38FES1.10717790
39SIK21.00992265
40CDK181.00712104
41CAMK2A1.00457680
42CDK140.99014814
43LATS20.97812110
44SGK2230.97742116
45SGK4940.97742116
46CDK150.96782504
47LMTK20.96012550
48OXSR10.95070355
49RIPK10.92607051
50PINK10.92453058
51TYRO30.86358433
52CDK11A0.84710383
53CAMK10.84343617
54PAK30.83376537
55PRKCH0.81765122
56NEK60.81665673
57CAMK2B0.81354206
58RET0.80867534
59TAOK10.79243102
60MAPK120.78905865
61NEK10.76873268
62PKN10.76186360
63RAF10.75367790
64BRSK10.74876398
65STK110.74852000
66NME10.73880970
67PTK2B0.73272523
68MAP3K110.71581823
69TESK10.71400462
70TNK20.70356496
71DYRK1A0.69891738
72CSNK1G20.69401263
73MAP3K10.69084971
74SGK20.69012374
75DYRK20.68072745
76SIK30.65026840
77WNK10.61694188
78CAMK2D0.59604549
79BMPR20.59366172
80PDK10.58337105
81PDPK10.58315662
82BRAF0.57621250
83CAMK2G0.57383674
84MARK20.56444205
85PRKCE0.56410499
86SGK10.56128482
87SGK30.54552740
88CCNB10.54184746
89FER0.53009641
90ALK0.51229049
91LIMK10.51184698
92PRKCZ0.48462764
93CSNK1G30.47814098
94MAP2K10.47731744
95DAPK30.47681034
96CDC42BPA0.46173132
97CSNK1A1L0.46084160
98BCR0.45518781
99RPS6KA30.43563315
100ROCK20.39406957
101WNK30.39295188
102SCYL20.38967410
103WNK40.38780405
104MAPK100.38443662
105RPS6KA20.37589144
106STK390.37500752
107FYN0.36822158
108CAMK40.36214720
109MAPKAPK50.36172566
110PRKCA0.35245345
111CAMK1G0.35052738
112PRKACA0.30370523
113MAPK80.28869203
114CSNK1D0.28706318
115CSNK1E0.28536836
116PRKG10.26511692
117CSNK1A10.26444480
118PRKCB0.25650900
119FGFR20.23126425

Predicted pathways (KEGG)

RankGene SetZ-score
1* Synaptic vesicle cycle_Homo sapiens_hsa047213.77827796
2Nicotine addiction_Homo sapiens_hsa050333.69144031
3GABAergic synapse_Homo sapiens_hsa047272.77228862
4Olfactory transduction_Homo sapiens_hsa047402.74665414
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65222398
6Circadian entrainment_Homo sapiens_hsa047132.62296082
7Long-term potentiation_Homo sapiens_hsa047202.51020035
8Morphine addiction_Homo sapiens_hsa050322.45431696
9Glutamatergic synapse_Homo sapiens_hsa047242.43244424
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.39294732
11Amphetamine addiction_Homo sapiens_hsa050312.37752703
12Dopaminergic synapse_Homo sapiens_hsa047282.17854189
13Salivary secretion_Homo sapiens_hsa049702.06659199
14Collecting duct acid secretion_Homo sapiens_hsa049662.02897514
15* Insulin secretion_Homo sapiens_hsa049112.00445681
16Cholinergic synapse_Homo sapiens_hsa047251.91494549
17Taste transduction_Homo sapiens_hsa047421.84588808
18Gastric acid secretion_Homo sapiens_hsa049711.79646460
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.77931772
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72732187
21Serotonergic synapse_Homo sapiens_hsa047261.69843668
22Cocaine addiction_Homo sapiens_hsa050301.65654034
23Long-term depression_Homo sapiens_hsa047301.64920456
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64784414
25Renin secretion_Homo sapiens_hsa049241.62894955
26Oxytocin signaling pathway_Homo sapiens_hsa049211.57610220
27Calcium signaling pathway_Homo sapiens_hsa040201.48273014
28GnRH signaling pathway_Homo sapiens_hsa049121.36751505
29Vibrio cholerae infection_Homo sapiens_hsa051101.35894607
30Cardiac muscle contraction_Homo sapiens_hsa042601.34868136
31Gap junction_Homo sapiens_hsa045401.31992074
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27998677
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27732857
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.21845852
35Vitamin B6 metabolism_Homo sapiens_hsa007501.21045411
36cAMP signaling pathway_Homo sapiens_hsa040241.16317291
37Type II diabetes mellitus_Homo sapiens_hsa049301.11645142
38Phototransduction_Homo sapiens_hsa047441.09106988
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.07418536
40Estrogen signaling pathway_Homo sapiens_hsa049151.06369644
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04598499
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02690291
43Oxidative phosphorylation_Homo sapiens_hsa001900.99961009
44Glioma_Homo sapiens_hsa052140.97285903
45Axon guidance_Homo sapiens_hsa043600.96262700
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95392705
47Melanogenesis_Homo sapiens_hsa049160.91779258
48ErbB signaling pathway_Homo sapiens_hsa040120.91399776
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90461995
50Alzheimers disease_Homo sapiens_hsa050100.87734231
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.87689770
52Oocyte meiosis_Homo sapiens_hsa041140.82623987
53Parkinsons disease_Homo sapiens_hsa050120.82035408
54Pancreatic secretion_Homo sapiens_hsa049720.80316508
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79706647
56Thyroid hormone synthesis_Homo sapiens_hsa049180.72872440
57Dorso-ventral axis formation_Homo sapiens_hsa043200.72618885
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.72245687
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71225074
60Dilated cardiomyopathy_Homo sapiens_hsa054140.69995258
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69826835
62MAPK signaling pathway_Homo sapiens_hsa040100.61984951
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61047598
64Choline metabolism in cancer_Homo sapiens_hsa052310.59835714
65Glucagon signaling pathway_Homo sapiens_hsa049220.59834117
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57975323
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57079285
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.56755077
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53745709
70Alcoholism_Homo sapiens_hsa050340.53460094
71Nitrogen metabolism_Homo sapiens_hsa009100.52903184
72Type I diabetes mellitus_Homo sapiens_hsa049400.51721343
73Circadian rhythm_Homo sapiens_hsa047100.51256839
74Ras signaling pathway_Homo sapiens_hsa040140.50993075
75VEGF signaling pathway_Homo sapiens_hsa043700.50074780
76Inositol phosphate metabolism_Homo sapiens_hsa005620.48609377
77Endocytosis_Homo sapiens_hsa041440.48253962
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48020758
79Huntingtons disease_Homo sapiens_hsa050160.47943526
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.44603041
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44518763
82Prion diseases_Homo sapiens_hsa050200.43919864
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.42717496
84Arginine and proline metabolism_Homo sapiens_hsa003300.41882053
85Insulin signaling pathway_Homo sapiens_hsa049100.41805856
86Bile secretion_Homo sapiens_hsa049760.41759233
87Rap1 signaling pathway_Homo sapiens_hsa040150.40243954
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38868576
89mTOR signaling pathway_Homo sapiens_hsa041500.37239959
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36839040
91Arginine biosynthesis_Homo sapiens_hsa002200.36675948
92Renal cell carcinoma_Homo sapiens_hsa052110.36086617
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35940982
94Rheumatoid arthritis_Homo sapiens_hsa053230.34118251
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33667495
96Endometrial cancer_Homo sapiens_hsa052130.33160004
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32505392
98AMPK signaling pathway_Homo sapiens_hsa041520.30634308
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30183627
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29993372
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29849247
102Non-small cell lung cancer_Homo sapiens_hsa052230.28395490
103Regulation of autophagy_Homo sapiens_hsa041400.28295438
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28102620
105Wnt signaling pathway_Homo sapiens_hsa043100.27305692
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.25487366
107Fatty acid biosynthesis_Homo sapiens_hsa000610.24181454
108Ovarian steroidogenesis_Homo sapiens_hsa049130.23972100
109Mineral absorption_Homo sapiens_hsa049780.21988392
110Tight junction_Homo sapiens_hsa045300.20689593
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19883810
112Hippo signaling pathway_Homo sapiens_hsa043900.18514398
113Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18425347

Most similar genes based on co-expression Upload to Enrichr

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