RAB39A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adaptation of signaling pathway (GO:0023058)5.36407293
2indole-containing compound catabolic process (GO:0042436)3.79090746
3indolalkylamine catabolic process (GO:0046218)3.79090746
4tryptophan catabolic process (GO:0006569)3.79090746
5positive regulation of cAMP-mediated signaling (GO:0043950)3.72396018
6kynurenine metabolic process (GO:0070189)3.49976909
7regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.47809115
8negative regulation of interleukin-12 production (GO:0032695)3.44731796
9positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.32502364
10positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24136595
11positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.23367066
12protein K11-linked deubiquitination (GO:0035871)3.22498358
13regulation of vitamin D biosynthetic process (GO:0060556)3.20142891
14regulation of meiosis I (GO:0060631)3.18641175
15indolalkylamine metabolic process (GO:0006586)3.17983279
16DNA deamination (GO:0045006)3.17587791
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16946644
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.16946644
19behavioral response to nicotine (GO:0035095)3.14937206
20tryptophan metabolic process (GO:0006568)3.13115923
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.12835794
22positive regulation of defense response to virus by host (GO:0002230)3.09766261
23regulation of chronic inflammatory response (GO:0002676)3.08999404
24positive regulation of interleukin-12 production (GO:0032735)3.02651607
25positive regulation of gamma-delta T cell activation (GO:0046645)2.99110087
26RNA destabilization (GO:0050779)2.97786207
27positive regulation of T-helper 1 type immune response (GO:0002827)2.95568956
28regulation of heat generation (GO:0031650)2.91452984
29regulation of interferon-gamma biosynthetic process (GO:0045072)2.87186095
30regulation of MHC class II biosynthetic process (GO:0045346)2.84917648
31positive regulation of interleukin-1 beta secretion (GO:0050718)2.82042152
32negative regulation of B cell proliferation (GO:0030889)2.81024459
33indole-containing compound metabolic process (GO:0042430)2.80521474
34regulation of T-helper 1 cell differentiation (GO:0045625)2.79353865
35regulation of interleukin-12 production (GO:0032655)2.79055271
36proline transport (GO:0015824)2.78777009
37interferon-gamma production (GO:0032609)2.77143563
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76387726
39positive regulation of heat generation (GO:0031652)2.75240371
40cellular response to ethanol (GO:0071361)2.70767553
41T cell migration (GO:0072678)2.69005376
42regulation of interferon-alpha production (GO:0032647)2.63224463
43regulation of interleukin-1 beta secretion (GO:0050706)2.61896660
44regulation of T-helper cell differentiation (GO:0045622)2.60099017
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.59124942
46regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.58667705
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.58027980
48negative regulation of translation, ncRNA-mediated (GO:0040033)2.58027980
49regulation of translation, ncRNA-mediated (GO:0045974)2.58027980
50cytidine catabolic process (GO:0006216)2.57474331
51cytidine deamination (GO:0009972)2.57474331
52cytidine metabolic process (GO:0046087)2.57474331
53synaptic transmission, cholinergic (GO:0007271)2.57456833
54regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.56917394
55negative regulation of interleukin-1 beta production (GO:0032691)2.56642461
56neural tube formation (GO:0001841)2.55510429
57positive regulation of interleukin-1 secretion (GO:0050716)2.55313529
58regulation of interleukin-12 biosynthetic process (GO:0045075)2.53638629
59DNA double-strand break processing (GO:0000729)2.48295796
60regulation of memory T cell differentiation (GO:0043380)2.46390266
61fucose catabolic process (GO:0019317)2.46100175
62L-fucose metabolic process (GO:0042354)2.46100175
63L-fucose catabolic process (GO:0042355)2.46100175
64signal peptide processing (GO:0006465)2.45921043
65regulation of gamma-delta T cell activation (GO:0046643)2.45472829
66positive regulation of antigen processing and presentation (GO:0002579)2.44410604
67serotonin metabolic process (GO:0042428)2.44256585
68positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.43476033
69protein localization to cilium (GO:0061512)2.43204595
70positive regulation of interleukin-10 production (GO:0032733)2.42701470
71B cell mediated immunity (GO:0019724)2.40616742
72negative regulation of mast cell activation (GO:0033004)2.40090672
73immunoglobulin mediated immune response (GO:0016064)2.39562841
74regulation of interleukin-8 biosynthetic process (GO:0045414)2.38977277
75regulation of fever generation (GO:0031620)2.37733057
76dopamine transport (GO:0015872)2.37080556
77somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.36789224
78somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.36789224
79isotype switching (GO:0045190)2.36789224
80regulation of hexokinase activity (GO:1903299)2.35516837
81regulation of glucokinase activity (GO:0033131)2.35516837
82regulation of nuclear cell cycle DNA replication (GO:0033262)2.34835342
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33588619
84interferon-gamma-mediated signaling pathway (GO:0060333)2.32540963
85negative regulation of interleukin-10 production (GO:0032693)2.32206431
86interferon-gamma secretion (GO:0072643)2.30395507
87negative regulation of B cell activation (GO:0050869)2.30116748
88DNA demethylation (GO:0080111)2.30103843
89pyrimidine ribonucleoside catabolic process (GO:0046133)2.29608125
90positive regulation of osteoclast differentiation (GO:0045672)2.29487305
91regulation of posttranscriptional gene silencing (GO:0060147)2.29486146
92regulation of gene silencing by miRNA (GO:0060964)2.29486146
93regulation of gene silencing by RNA (GO:0060966)2.29486146
94nerve growth factor signaling pathway (GO:0038180)2.29483099
95T-helper cell differentiation (GO:0042093)2.29122278
96CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.29122278
97primary amino compound metabolic process (GO:1901160)2.29048683
98piRNA metabolic process (GO:0034587)2.27610531
99regulation of T-helper 1 type immune response (GO:0002825)2.27432007
100regulation of interleukin-10 production (GO:0032653)2.26412137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.83818599
2IRF8_22096565_ChIP-ChIP_GC-B_Human2.76996209
3IRF8_21731497_ChIP-ChIP_J774_Mouse2.76660570
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69247343
5ZNF274_21170338_ChIP-Seq_K562_Hela2.64222433
6NOTCH1_21737748_ChIP-Seq_TLL_Human2.64204498
7MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.44131533
8GBX2_23144817_ChIP-Seq_PC3_Human2.42723867
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37438038
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36617869
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36231759
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.19731348
13P300_19829295_ChIP-Seq_ESCs_Human2.12882522
14EWS_26573619_Chip-Seq_HEK293_Human2.11467934
15IGF1R_20145208_ChIP-Seq_DFB_Human2.11132399
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.06860648
17VDR_22108803_ChIP-Seq_LS180_Human2.06321060
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.99202781
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.98159482
20GATA1_22025678_ChIP-Seq_K562_Human1.97237715
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96813510
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.94594732
23TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94594732
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.92870446
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.84124464
26TAF15_26573619_Chip-Seq_HEK293_Human1.84085252
27FUS_26573619_Chip-Seq_HEK293_Human1.80335065
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68411035
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.67304114
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64850465
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63223014
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58193901
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57621143
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54219054
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53840133
36IRF8_27001747_Chip-Seq_BMDM_Mouse1.53091085
37EZH2_22144423_ChIP-Seq_EOC_Human1.52272262
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.51779587
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51732190
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50379685
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47500960
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.46780611
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44749611
44STAT3_23295773_ChIP-Seq_U87_Human1.42324225
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.41584327
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40842337
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.38184755
48CBP_20019798_ChIP-Seq_JUKART_Human1.35470322
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35470322
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.33093161
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.32991731
52SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32452182
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31865834
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31762818
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.31707936
56NANOG_18555785_Chip-Seq_ESCs_Mouse1.30982770
57SMAD4_21799915_ChIP-Seq_A2780_Human1.28249771
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26379140
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25938698
60TCF4_23295773_ChIP-Seq_U87_Human1.25320403
61ER_23166858_ChIP-Seq_MCF-7_Human1.24633339
62STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19380690
63ELK1_19687146_ChIP-ChIP_HELA_Human1.16438623
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16317391
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.15084216
66SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14656196
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.14487747
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14385829
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.13169101
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12494788
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.11855134
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.11340065
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11053454
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.10634342
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10544365
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.09978538
77TP53_22573176_ChIP-Seq_HFKS_Human1.09853292
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09656869
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.09149582
80NANOG_19829295_ChIP-Seq_ESCs_Human1.08762013
81SOX2_19829295_ChIP-Seq_ESCs_Human1.08762013
82SMRT_27268052_Chip-Seq_Bcells_Human1.08162743
83P53_22387025_ChIP-Seq_ESCs_Mouse1.08001534
84BCAT_22108803_ChIP-Seq_LS180_Human1.07938599
85P300_18555785_Chip-Seq_ESCs_Mouse1.07304299
86RUNX2_22187159_ChIP-Seq_PCA_Human1.07080322
87MYC_18940864_ChIP-ChIP_HL60_Human1.06834704
88VDR_24787735_ChIP-Seq_THP-1_Human1.06414157
89GATA3_26560356_Chip-Seq_TH2_Human1.06307172
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.06157768
91AR_25329375_ChIP-Seq_VCAP_Human1.06069271
92KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05493920
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05175154
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.04148343
95NMYC_18555785_Chip-Seq_ESCs_Mouse1.03062822
96CDX2_22108803_ChIP-Seq_LS180_Human1.01196258
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01072390
98IRF1_19129219_ChIP-ChIP_H3396_Human1.01059498
99PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00874917
100TCF4_22108803_ChIP-Seq_LS180_Human1.00652481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.78534735
2MP0008057_abnormal_DNA_replication3.76380242
3MP0005671_abnormal_response_to3.05396261
4MP0003195_calcinosis2.99608554
5MP0001835_abnormal_antigen_presentation2.81717906
6MP0003646_muscle_fatigue2.47693589
7MP0006082_CNS_inflammation2.34566968
8MP0008877_abnormal_DNA_methylation2.28692235
9MP0009785_altered_susceptibility_to2.28291583
10MP0000372_irregular_coat_pigmentation2.25561237
11MP0005387_immune_system_phenotype2.05477098
12MP0001790_abnormal_immune_system2.05477098
13MP0005310_abnormal_salivary_gland2.04796862
14MP0003136_yellow_coat_color1.96894910
15MP0002254_reproductive_system_inflammat1.94114858
16MP0002638_abnormal_pupillary_reflex1.91953280
17MP0002148_abnormal_hypersensitivity_rea1.86931578
18MP0001800_abnormal_humoral_immune1.82593564
19MP0004742_abnormal_vestibular_system1.79596851
20MP0003303_peritoneal_inflammation1.79562773
21MP0003880_abnormal_central_pattern1.74497410
22MP0005000_abnormal_immune_tolerance1.72786974
23MP0003724_increased_susceptibility_to1.71547343
24MP0009745_abnormal_behavioral_response1.70526327
25MP0005645_abnormal_hypothalamus_physiol1.69013451
26MP0002452_abnormal_antigen_presenting1.65316561
27MP0002138_abnormal_hepatobiliary_system1.63786101
28MP0005647_abnormal_sex_gland1.62033175
29MP0002102_abnormal_ear_morphology1.58824699
30MP0003806_abnormal_nucleotide_metabolis1.57466829
31MP0002723_abnormal_immune_serum1.53799440
32MP0003787_abnormal_imprinting1.52896635
33MP0003890_abnormal_embryonic-extraembry1.52439281
34MP0002163_abnormal_gland_morphology1.51783568
35MP0005075_abnormal_melanosome_morpholog1.50316409
36MP0000015_abnormal_ear_pigmentation1.46394472
37MP0009046_muscle_twitch1.42838770
38MP0002277_abnormal_respiratory_mucosa1.39797351
39MP0000685_abnormal_immune_system1.39589582
40MP0001968_abnormal_touch/_nociception1.39378399
41MP0002751_abnormal_autonomic_nervous1.37501059
42MP0005025_abnormal_response_to1.35218526
43MP0001501_abnormal_sleep_pattern1.33664877
44MP0005167_abnormal_blood-brain_barrier1.31045602
45MP0010386_abnormal_urinary_bladder1.29532914
46MP0009764_decreased_sensitivity_to1.27755383
47MP0008058_abnormal_DNA_repair1.27458074
48MP0002419_abnormal_innate_immunity1.27226170
49MP0005379_endocrine/exocrine_gland_phen1.26992307
50MP0001819_abnormal_immune_cell1.21691848
51MP0002420_abnormal_adaptive_immunity1.21421715
52MP0005253_abnormal_eye_physiology1.21341689
53MP0005174_abnormal_tail_pigmentation1.14218858
54MP0002736_abnormal_nociception_after1.10932546
55MP0002693_abnormal_pancreas_physiology1.10873232
56MP0010094_abnormal_chromosome_stability1.09529839
57MP0006035_abnormal_mitochondrial_morpho1.07470855
58MP0002735_abnormal_chemical_nociception1.07432300
59MP0001986_abnormal_taste_sensitivity1.05360118
60MP0002837_dystrophic_cardiac_calcinosis1.04251388
61MP0002064_seizures1.00810053
62MP0000371_diluted_coat_color0.97719954
63MP0001845_abnormal_inflammatory_respons0.96898559
64MP0001324_abnormal_eye_pigmentation0.95774181
65MP0002090_abnormal_vision0.95506396
66MP0005551_abnormal_eye_electrophysiolog0.94716281
67MP0002006_tumorigenesis0.91447399
68MP0000716_abnormal_immune_system0.89497654
69MP0004381_abnormal_hair_follicle0.88875951
70MP0001919_abnormal_reproductive_system0.88687280
71MP0002733_abnormal_thermal_nociception0.87967841
72MP0001970_abnormal_pain_threshold0.85078618
73MP0000383_abnormal_hair_follicle0.84745524
74MP0000604_amyloidosis0.84716525
75MP0000427_abnormal_hair_cycle0.83806162
76MP0008872_abnormal_physiological_respon0.81895275
77MP0000689_abnormal_spleen_morphology0.81317384
78MP0006276_abnormal_autonomic_nervous0.81270759
79MP0002009_preneoplasia0.80702175
80MP0004924_abnormal_behavior0.79928016
81MP0005386_behavior/neurological_phenoty0.79928016
82MP0002572_abnormal_emotion/affect_behav0.79077926
83MP0002405_respiratory_system_inflammati0.79000340
84MP0008007_abnormal_cellular_replicative0.78891232
85MP0006072_abnormal_retinal_apoptosis0.78729038
86MP0008469_abnormal_protein_level0.77942284
87MP0002272_abnormal_nervous_system0.76891559
88MP0005423_abnormal_somatic_nervous0.76420829
89MP0002398_abnormal_bone_marrow0.76177003
90MP0005266_abnormal_metabolism0.76042259
91MP0003172_abnormal_lysosome_physiology0.75643265
92MP0002067_abnormal_sensory_capabilities0.75030702
93MP0002166_altered_tumor_susceptibility0.74755749
94MP0003448_altered_tumor_morphology0.74058381
95MP0002229_neurodegeneration0.74036673
96MP0003633_abnormal_nervous_system0.73751919
97MP0010307_abnormal_tumor_latency0.73445783
98MP0001486_abnormal_startle_reflex0.73123367
99MP0003567_abnormal_fetal_cardiomyocyte0.73020900
100MP0002095_abnormal_skin_pigmentation0.69062541

Predicted human phenotypes

RankGene SetZ-score
1Agnosia (HP:0010524)3.07500852
2Prostate neoplasm (HP:0100787)3.04791466
3Abolished electroretinogram (ERG) (HP:0000550)2.99576362
4Gaze-evoked nystagmus (HP:0000640)2.97972859
5T lymphocytopenia (HP:0005403)2.96936647
6Stomatitis (HP:0010280)2.94701378
7Abnormality of the prostate (HP:0008775)2.93493147
8Intestinal atresia (HP:0011100)2.91715629
9Hyperventilation (HP:0002883)2.90205137
10Abnormality of T cell number (HP:0011839)2.89279245
11Congenital stationary night blindness (HP:0007642)2.84189175
12Pendular nystagmus (HP:0012043)2.79541583
13Progressive inability to walk (HP:0002505)2.60030129
14Mutism (HP:0002300)2.57934817
15Optic neuritis (HP:0100653)2.48772042
16Retrobulbar optic neuritis (HP:0100654)2.48772042
17Abnormality of glycolipid metabolism (HP:0010969)2.47882676
18Abnormality of liposaccharide metabolism (HP:0010968)2.47882676
19Abnormality of glycosphingolipid metabolism (HP:0004343)2.47882676
20Recurrent bacterial skin infections (HP:0005406)2.46983064
21Protruding tongue (HP:0010808)2.41072198
22Inappropriate behavior (HP:0000719)2.40616484
23Hematochezia (HP:0002573)2.36763694
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.36158984
25Colon cancer (HP:0003003)2.34845250
26Septo-optic dysplasia (HP:0100842)2.33951927
27IgG deficiency (HP:0004315)2.33643685
28Chronic diarrhea (HP:0002028)2.29092199
29Inability to walk (HP:0002540)2.26922978
30Amaurosis fugax (HP:0100576)2.26740343
31Limb hypertonia (HP:0002509)2.26454054
32Abnormality of chromosome stability (HP:0003220)2.21912950
33IgA deficiency (HP:0002720)2.20907203
34Disinhibition (HP:0000734)2.18645316
35Vacuolated lymphocytes (HP:0001922)2.16724624
36Recurrent cutaneous fungal infections (HP:0011370)2.15813408
37Chronic mucocutaneous candidiasis (HP:0002728)2.15813408
38Mediastinal lymphadenopathy (HP:0100721)2.15736759
39Pancreatic cysts (HP:0001737)2.09856853
40Abnormality of the labia minora (HP:0012880)2.09710084
41Hemoptysis (HP:0002105)2.09260434
42Broad-based gait (HP:0002136)2.07676175
43Chromsome breakage (HP:0040012)2.07231303
44Abnormality of midbrain morphology (HP:0002418)2.05475087
45Molar tooth sign on MRI (HP:0002419)2.05475087
46Increased IgM level (HP:0003496)2.04894741
47Hypoplasia of the fovea (HP:0007750)2.03560919
48Aplasia/Hypoplasia of the fovea (HP:0008060)2.03560919
49Fair hair (HP:0002286)2.02981529
50Abnormality of male internal genitalia (HP:0000022)2.00793419
51Volvulus (HP:0002580)2.00280604
52Increased cerebral lipofuscin (HP:0011813)1.99884848
53Dialeptic seizures (HP:0011146)1.99728645
54Constricted visual fields (HP:0001133)1.96691368
55Agitation (HP:0000713)1.94404308
56Generalized hypopigmentation of hair (HP:0011358)1.94312607
57Autoimmune thrombocytopenia (HP:0001973)1.93190287
58Albinism (HP:0001022)1.90178211
59Recurrent skin infections (HP:0001581)1.89406862
60Recurrent abscess formation (HP:0002722)1.88583967
61Thyroiditis (HP:0100646)1.88035574
62Clumsiness (HP:0002312)1.87733241
63Abnormality of the fovea (HP:0000493)1.87576502
64Drooling (HP:0002307)1.87263105
65Congenital sensorineural hearing impairment (HP:0008527)1.85095240
66Abnormality of the anterior horn cell (HP:0006802)1.84851624
67Degeneration of anterior horn cells (HP:0002398)1.84851624
68Recurrent fungal infections (HP:0002841)1.84521597
69Polyneuropathy (HP:0001271)1.83532706
70Abnormality of alanine metabolism (HP:0010916)1.82726493
71Hyperalaninemia (HP:0003348)1.82726493
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.82726493
73Spinal muscular atrophy (HP:0007269)1.81956779
74Attenuation of retinal blood vessels (HP:0007843)1.81365287
75Genetic anticipation (HP:0003743)1.80185022
76Cortical dysplasia (HP:0002539)1.79913467
77Abnormality of the renal cortex (HP:0011035)1.75883984
78Excessive salivation (HP:0003781)1.75867759
79Urinary bladder sphincter dysfunction (HP:0002839)1.75843935
80Absent speech (HP:0001344)1.75617041
81Increased neuronal autofluorescent lipopigment (HP:0002074)1.75456062
82Dyschromatopsia (HP:0007641)1.74283926
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.73749214
84Carpal bone hypoplasia (HP:0001498)1.73749126
85Keratoconjunctivitis (HP:0001096)1.73425168
86Orchitis (HP:0100796)1.73304710
87Abnormality of the ileum (HP:0001549)1.72793904
88Flat occiput (HP:0005469)1.72013131
89Medulloblastoma (HP:0002885)1.68842577
90Metaphyseal irregularity (HP:0003025)1.68312301
91Rhabdomyosarcoma (HP:0002859)1.67766183
92Progressive cerebellar ataxia (HP:0002073)1.67449653
93Aplasia/hypoplasia of the uterus (HP:0008684)1.67030832
94Horizontal nystagmus (HP:0000666)1.66983286
95Abnormality of T cells (HP:0002843)1.66833317
96Combined immunodeficiency (HP:0005387)1.66428198
97Meckel diverticulum (HP:0002245)1.65582887
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65016425
99Pancreatic fibrosis (HP:0100732)1.63602317
100Pulmonary infiltrates (HP:0002113)1.62270045

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.56433575
2TXK3.21370552
3ADRBK22.90462703
4ACVR1B2.72652383
5ZAK2.67684238
6CASK2.32423608
7TRIM282.31547893
8MKNK22.25560262
9GRK72.12145466
10BMPR1B1.95698785
11TNIK1.87854170
12TLK11.71075816
13WNK31.68615503
14TSSK61.58378252
15PINK11.53902522
16MKNK11.46083054
17BLK1.43891483
18MATK1.43442882
19MAP3K141.36687363
20TAF11.34179866
21IKBKB1.33693965
22BRD41.32873770
23TAOK31.31315496
24BCR1.30763063
25VRK11.30506229
26NUAK11.29785933
27FGR1.29700082
28MST41.29630952
29PNCK1.25694115
30PLK31.20916496
31DAPK21.19803620
32PLK21.18190395
33MAP3K41.17488951
34CSNK1G21.14547437
35TYK21.12294206
36SRPK11.10394639
37CDC71.09535275
38NLK1.04845046
39INSRR1.02570894
40CSNK1G30.99949333
41EIF2AK30.99576335
42CSNK1G10.97251497
43OXSR10.96377736
44PRKCG0.95529887
45IKBKE0.93617276
46DYRK20.93318014
47IRAK10.92899782
48MARK30.92134898
49CHUK0.91453392
50RIPK40.88950415
51GRK10.86515219
52MAP4K10.84852051
53TAOK10.83374527
54PLK40.82746058
55CSNK1A1L0.82383632
56MAPK130.80642583
57CAMKK20.80531448
58LYN0.78412038
59WEE10.74646634
60TEC0.74442240
61MAP4K20.72302815
62DAPK10.72248441
63BMPR20.71817545
64CSK0.71216975
65JAK10.69618176
66CAMK1D0.69600557
67IRAK40.69140057
68ITK0.68891443
69SYK0.68411631
70SGK20.67480545
71STK30.66618143
72CAMK1G0.65405251
73JAK20.63847183
74JAK30.63653545
75STK38L0.61267438
76PRKCE0.60566028
77TTK0.60546532
78CSF1R0.57267723
79CDK60.56812704
80YES10.56379447
81PIM10.56080433
82ALK0.55573400
83CHEK20.55486625
84EIF2AK20.54965465
85ATR0.54166699
86IRAK20.54117800
87PAK30.53816657
88DYRK30.53546788
89MAP2K70.53214667
90ERBB30.52484429
91EPHA40.50800754
92PRKAA20.48666430
93ATM0.48517006
94PRKCQ0.46760864
95PKN10.46538503
96IRAK30.45659286
97EGFR0.45572013
98PLK10.45501307
99CSNK1A10.43453376
100STK110.39883985

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.17856088
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.96499940
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.82950701
4Type I diabetes mellitus_Homo sapiens_hsa049402.82749435
5Autoimmune thyroid disease_Homo sapiens_hsa053202.63978227
6Asthma_Homo sapiens_hsa053102.62036476
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.60950345
8Graft-versus-host disease_Homo sapiens_hsa053322.56986481
9Rheumatoid arthritis_Homo sapiens_hsa053232.35518637
10Selenocompound metabolism_Homo sapiens_hsa004502.13069750
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02704112
12Nicotine addiction_Homo sapiens_hsa050332.02479045
13Non-homologous end-joining_Homo sapiens_hsa034502.02124372
14Antigen processing and presentation_Homo sapiens_hsa046122.00162835
15Legionellosis_Homo sapiens_hsa051341.96899535
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95510083
17Primary immunodeficiency_Homo sapiens_hsa053401.89041080
18Staphylococcus aureus infection_Homo sapiens_hsa051501.68421418
19Homologous recombination_Homo sapiens_hsa034401.67996309
20Systemic lupus erythematosus_Homo sapiens_hsa053221.65367405
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.65032550
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64034349
23Leishmaniasis_Homo sapiens_hsa051401.63585985
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.45811046
25Tuberculosis_Homo sapiens_hsa051521.41351695
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40293400
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30425853
28Phototransduction_Homo sapiens_hsa047441.29108064
29Dorso-ventral axis formation_Homo sapiens_hsa043201.27794084
30Taste transduction_Homo sapiens_hsa047421.27494715
31Osteoclast differentiation_Homo sapiens_hsa043801.27138022
32Tryptophan metabolism_Homo sapiens_hsa003801.24277302
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21499360
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21173600
35Hematopoietic cell lineage_Homo sapiens_hsa046401.18445353
36Measles_Homo sapiens_hsa051621.18051155
37Herpes simplex infection_Homo sapiens_hsa051681.15478237
38Basal transcription factors_Homo sapiens_hsa030221.12776514
39African trypanosomiasis_Homo sapiens_hsa051431.12309736
40Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11811822
41Ether lipid metabolism_Homo sapiens_hsa005651.05449943
42Lysosome_Homo sapiens_hsa041421.03689289
43Fanconi anemia pathway_Homo sapiens_hsa034601.02067738
44Collecting duct acid secretion_Homo sapiens_hsa049660.98854312
45Influenza A_Homo sapiens_hsa051640.98660757
46Caffeine metabolism_Homo sapiens_hsa002320.98573832
47Proteasome_Homo sapiens_hsa030500.97029177
48RNA polymerase_Homo sapiens_hsa030200.94641054
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.93238994
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.93097099
51RNA degradation_Homo sapiens_hsa030180.92039665
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.91794932
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85272324
54Maturity onset diabetes of the young_Homo sapiens_hsa049500.85047828
55T cell receptor signaling pathway_Homo sapiens_hsa046600.84843343
56Morphine addiction_Homo sapiens_hsa050320.83583074
57Protein export_Homo sapiens_hsa030600.82301322
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78183122
59Chemokine signaling pathway_Homo sapiens_hsa040620.78039032
60Circadian rhythm_Homo sapiens_hsa047100.73717623
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70199599
62B cell receptor signaling pathway_Homo sapiens_hsa046620.65677381
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64366053
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63556536
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63298860
66Viral myocarditis_Homo sapiens_hsa054160.63148862
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62491582
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62395515
69Phagosome_Homo sapiens_hsa041450.60223633
70One carbon pool by folate_Homo sapiens_hsa006700.59812398
71Fatty acid biosynthesis_Homo sapiens_hsa000610.59654605
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58545211
73Glutamatergic synapse_Homo sapiens_hsa047240.57735560
74TNF signaling pathway_Homo sapiens_hsa046680.57605288
75Pertussis_Homo sapiens_hsa051330.57312976
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55172303
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53874559
78RNA transport_Homo sapiens_hsa030130.53409482
79GABAergic synapse_Homo sapiens_hsa047270.53064827
80Toxoplasmosis_Homo sapiens_hsa051450.52707688
81Serotonergic synapse_Homo sapiens_hsa047260.51775620
82Linoleic acid metabolism_Homo sapiens_hsa005910.51509409
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51387080
84Regulation of autophagy_Homo sapiens_hsa041400.51315152
85Epstein-Barr virus infection_Homo sapiens_hsa051690.51240514
86Mismatch repair_Homo sapiens_hsa034300.50772312
87Olfactory transduction_Homo sapiens_hsa047400.50493143
88Long-term depression_Homo sapiens_hsa047300.48006839
89Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45533724
90Alcoholism_Homo sapiens_hsa050340.43112167
91Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42621386
92Type II diabetes mellitus_Homo sapiens_hsa049300.42099452
93Butanoate metabolism_Homo sapiens_hsa006500.41272683
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38289972
95Malaria_Homo sapiens_hsa051440.37840723
96Spliceosome_Homo sapiens_hsa030400.35764018
97Steroid biosynthesis_Homo sapiens_hsa001000.32823919
98Hepatitis B_Homo sapiens_hsa051610.31891484
99Mineral absorption_Homo sapiens_hsa049780.30500051
100Oocyte meiosis_Homo sapiens_hsa041140.29133865

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