RAB2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.27682559
2neuron cell-cell adhesion (GO:0007158)5.25713883
3pyrimidine nucleobase catabolic process (GO:0006208)4.89155712
4neural tube formation (GO:0001841)4.47782296
5presynaptic membrane assembly (GO:0097105)4.26692039
6central nervous system myelination (GO:0022010)4.26153915
7axon ensheathment in central nervous system (GO:0032291)4.26153915
8synaptic vesicle exocytosis (GO:0016079)4.19457667
9nucleobase catabolic process (GO:0046113)4.14617038
10presynaptic membrane organization (GO:0097090)4.03081296
11vocalization behavior (GO:0071625)3.79671456
12glutamate secretion (GO:0014047)3.78106236
13regulation of cilium movement (GO:0003352)3.75916606
14negative regulation of neurotransmitter transport (GO:0051589)3.75591501
15regulation of synaptic vesicle exocytosis (GO:2000300)3.69173190
16postsynaptic membrane organization (GO:0001941)3.69137486
17sulfation (GO:0051923)3.68937389
18protein localization to synapse (GO:0035418)3.67938342
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.65002741
20neuron recognition (GO:0008038)3.58128732
21neuronal action potential propagation (GO:0019227)3.56995513
22long-chain fatty acid biosynthetic process (GO:0042759)3.54605217
23dopamine transport (GO:0015872)3.51611491
24activated T cell proliferation (GO:0050798)3.50479136
25axonal fasciculation (GO:0007413)3.50104556
26negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46653666
27synaptic vesicle maturation (GO:0016188)3.44595434
28L-fucose catabolic process (GO:0042355)3.43826939
29fucose catabolic process (GO:0019317)3.43826939
30L-fucose metabolic process (GO:0042354)3.43826939
31regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.39639300
32protein K11-linked deubiquitination (GO:0035871)3.39252454
33protein localization to cilium (GO:0061512)3.35434604
34positive regulation of synapse assembly (GO:0051965)3.34238273
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30135096
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.29237819
37epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.23884103
38neuron-neuron synaptic transmission (GO:0007270)3.23122223
39gamma-aminobutyric acid signaling pathway (GO:0007214)3.17412375
40negative regulation of mast cell activation (GO:0033004)3.15702265
41regulation of glutamate receptor signaling pathway (GO:1900449)3.15554766
42establishment of protein localization to Golgi (GO:0072600)3.15285531
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14648741
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.14527254
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.14431866
46membrane assembly (GO:0071709)3.14386804
47startle response (GO:0001964)3.14184415
48indolalkylamine metabolic process (GO:0006586)3.13370088
49negative regulation of protein localization to cell surface (GO:2000009)3.12558651
50negative regulation of neurotransmitter secretion (GO:0046929)3.12161981
51glutamate receptor signaling pathway (GO:0007215)3.12153329
52positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.12071404
53mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.12071404
54cAMP catabolic process (GO:0006198)3.11775437
55cell migration in hindbrain (GO:0021535)3.10288600
56synaptic transmission, glutamatergic (GO:0035249)3.09975781
57dendrite development (GO:0016358)3.09159096
58somite development (GO:0061053)3.08115885
59gamma-aminobutyric acid transport (GO:0015812)3.07552233
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06591057
61regulation of synaptic vesicle transport (GO:1902803)3.03840663
62locomotory exploration behavior (GO:0035641)3.03041389
63transmission of nerve impulse (GO:0019226)3.02138583
64negative regulation of dendrite morphogenesis (GO:0050774)3.00261079
65tryptophan catabolic process (GO:0006569)2.98666733
66indole-containing compound catabolic process (GO:0042436)2.98666733
67indolalkylamine catabolic process (GO:0046218)2.98666733
68epithelial cilium movement (GO:0003351)2.98324086
69kynurenine metabolic process (GO:0070189)2.95598500
70protein polyglutamylation (GO:0018095)2.95023557
71protein neddylation (GO:0045116)2.94542484
72cerebral cortex radially oriented cell migration (GO:0021799)2.94432513
73mechanosensory behavior (GO:0007638)2.90758131
74retinal ganglion cell axon guidance (GO:0031290)2.86871045
75regulation of neurotransmitter secretion (GO:0046928)2.86034637
76neurotransmitter-gated ion channel clustering (GO:0072578)2.85762511
77synaptic vesicle docking involved in exocytosis (GO:0016081)2.85407044
78detection of light stimulus involved in sensory perception (GO:0050962)2.84287000
79detection of light stimulus involved in visual perception (GO:0050908)2.84287000
80neurotransmitter uptake (GO:0001504)2.83918286
81long-term synaptic potentiation (GO:0060291)2.82555335
82dendritic spine morphogenesis (GO:0060997)2.82437379
83cyclic nucleotide catabolic process (GO:0009214)2.81931180
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.81872713
85negative regulation of telomere maintenance (GO:0032205)2.80935835
86platelet dense granule organization (GO:0060155)2.80624182
87regulation of synapse assembly (GO:0051963)2.79638573
88regulation of collateral sprouting (GO:0048670)2.79582866
89regulation of telomere maintenance (GO:0032204)2.77652541
90nonmotile primary cilium assembly (GO:0035058)2.77181637
91tryptophan metabolic process (GO:0006568)2.77054008
92reflex (GO:0060004)2.75589290
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.74638246
94negative regulation of axon extension (GO:0030517)2.74434700
95exploration behavior (GO:0035640)2.74278633
96protein targeting to Golgi (GO:0000042)2.73756866
97auditory behavior (GO:0031223)2.73661082
98negative regulation of axonogenesis (GO:0050771)2.73508952
99embryonic epithelial tube formation (GO:0001838)2.73332083
100regulation of synaptic transmission, glutamatergic (GO:0051966)2.72296185
101regulation of voltage-gated calcium channel activity (GO:1901385)2.72139210
102transferrin transport (GO:0033572)2.71961735
103regulation of neuronal synaptic plasticity (GO:0048168)2.71522366
104fatty acid elongation (GO:0030497)2.71439716
105positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69640533
106response to pheromone (GO:0019236)2.67040092
107neurotransmitter secretion (GO:0007269)2.66629889
108adult walking behavior (GO:0007628)2.66519279
109regulation of microtubule-based movement (GO:0060632)2.66506188
110kidney morphogenesis (GO:0060993)2.66361232
111regulation of respiratory system process (GO:0044065)2.66034716
112regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.65843446
113positive regulation of membrane potential (GO:0045838)2.64758195
114regulation of synapse structural plasticity (GO:0051823)2.64571825
115cerebellar granule cell differentiation (GO:0021707)2.64011724
116neuronal action potential (GO:0019228)2.63880852
117DNA deamination (GO:0045006)2.63832533
118neuronal ion channel clustering (GO:0045161)2.63185381
119regulation of neurotransmitter transport (GO:0051588)2.63012171
120dopamine biosynthetic process (GO:0042416)2.62016120
121synaptic transmission, cholinergic (GO:0007271)2.61512981
122regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61499930
123cilium organization (GO:0044782)2.60946230
124regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60806385
125photoreceptor cell development (GO:0042461)2.60581735
126synapse assembly (GO:0007416)2.60347503
127regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.60032713
128regulation of dopamine metabolic process (GO:0042053)2.59486625
129regulation of catecholamine metabolic process (GO:0042069)2.59486625
130regulation of action potential (GO:0098900)2.58886613
131cerebellar Purkinje cell differentiation (GO:0021702)2.58531543
132response to histamine (GO:0034776)2.58080799
133regulation of postsynaptic membrane potential (GO:0060078)2.57828614
134negative regulation of dendrite development (GO:2000171)2.57763673
135protein K48-linked deubiquitination (GO:0071108)2.57132821
136mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.56827824
137chaperone-mediated protein transport (GO:0072321)2.56458462
138myelination (GO:0042552)2.56251135
139innervation (GO:0060384)2.55951248
140detection of temperature stimulus involved in sensory perception (GO:0050961)2.55805085
141detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.55805085
142cilium assembly (GO:0042384)2.55680588
143proline transport (GO:0015824)2.55595762
144serotonin receptor signaling pathway (GO:0007210)2.54957172
145establishment of mitochondrion localization (GO:0051654)2.54873500
146central nervous system neuron axonogenesis (GO:0021955)2.54848947
147cilium morphogenesis (GO:0060271)2.54806625
148regulation of glutamate secretion (GO:0014048)2.54665863
149peristalsis (GO:0030432)2.53986268
150positive regulation of mitochondrial fission (GO:0090141)2.53863442
151limb bud formation (GO:0060174)2.53671459
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.52923998
153learning (GO:0007612)2.52726884
154central nervous system projection neuron axonogenesis (GO:0021952)2.52010182
155synaptic vesicle endocytosis (GO:0048488)2.51492086
156response to cocaine (GO:0042220)2.51348232
157negative regulation of transcription regulatory region DNA binding (GO:2000678)2.51055968
158epithelial tube formation (GO:0072175)2.49718449
159glycosphingolipid biosynthetic process (GO:0006688)2.49222687
160photoreceptor cell maintenance (GO:0045494)2.49091374
161water-soluble vitamin biosynthetic process (GO:0042364)2.48885793
162axoneme assembly (GO:0035082)2.48810292
163negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48519727
164cornea development in camera-type eye (GO:0061303)2.46380396
165otic vesicle formation (GO:0030916)2.44449360
166retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44321839
167indole-containing compound metabolic process (GO:0042430)2.43820290
168cellular ketone body metabolic process (GO:0046950)2.43623417
169regulation of neurotransmitter uptake (GO:0051580)2.42918309
170olfactory bulb development (GO:0021772)2.41729424
171cell proliferation in forebrain (GO:0021846)2.39925968
172dentate gyrus development (GO:0021542)2.38895163
173primary amino compound metabolic process (GO:1901160)2.38690519
174eye photoreceptor cell development (GO:0042462)2.38564870
175microtubule anchoring (GO:0034453)2.37956592
176serotonin metabolic process (GO:0042428)2.37033973
177adaptation of signaling pathway (GO:0023058)2.35742583
178behavioral response to ethanol (GO:0048149)2.35105936
179monoubiquitinated protein deubiquitination (GO:0035520)2.34152190
180regulation of dopamine secretion (GO:0014059)2.33842558
181polyol catabolic process (GO:0046174)2.33198161
182retinal cone cell development (GO:0046549)2.32622436
183negative regulation of systemic arterial blood pressure (GO:0003085)2.29218435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.94492855
2GBX2_23144817_ChIP-Seq_PC3_Human4.45326987
3TAF15_26573619_Chip-Seq_HEK293_Human3.20648140
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88857633
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77304316
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.70431644
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.58798238
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.53769891
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.37078119
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37025154
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36888849
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.29811054
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28530896
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28530896
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.24278085
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17413757
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.17083454
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11993426
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.10290950
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09503158
21REST_21632747_ChIP-Seq_MESCs_Mouse2.09091829
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.05182149
23CBX2_27304074_Chip-Seq_ESCs_Mouse1.96264196
24SUZ12_27294783_Chip-Seq_ESCs_Mouse1.94274056
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94071247
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93117597
27CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92879476
28EZH2_27294783_Chip-Seq_ESCs_Mouse1.92878627
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91116199
30P300_19829295_ChIP-Seq_ESCs_Human1.90076158
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.89774570
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85855213
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.81494275
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.78100549
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.75552982
36FUS_26573619_Chip-Seq_HEK293_Human1.74707538
37IGF1R_20145208_ChIP-Seq_DFB_Human1.72309445
38CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72103707
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71341790
40SMAD4_21799915_ChIP-Seq_A2780_Human1.68286980
41VDR_22108803_ChIP-Seq_LS180_Human1.64800405
42RNF2_27304074_Chip-Seq_NSC_Mouse1.63670266
43REST_18959480_ChIP-ChIP_MESCs_Mouse1.63307035
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63079462
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62412844
46ER_23166858_ChIP-Seq_MCF-7_Human1.57171349
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.56868285
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54582213
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53261977
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.52904246
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51820392
52CBP_20019798_ChIP-Seq_JUKART_Human1.48519037
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48519037
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46959007
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46378979
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.43807356
57BCAT_22108803_ChIP-Seq_LS180_Human1.41371123
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40619860
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.39857725
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.37981304
61AR_21572438_ChIP-Seq_LNCaP_Human1.36239190
62ZNF274_21170338_ChIP-Seq_K562_Hela1.35953210
63FLI1_21867929_ChIP-Seq_TH2_Mouse1.35635267
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34283012
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33930413
66DROSHA_22980978_ChIP-Seq_HELA_Human1.31386091
67EWS_26573619_Chip-Seq_HEK293_Human1.31277458
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.28460264
69CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28414943
70JUN_21703547_ChIP-Seq_K562_Human1.26520708
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.25795419
72STAT3_23295773_ChIP-Seq_U87_Human1.25525057
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24008056
74FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.23908092
75EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23478737
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23096252
77AR_25329375_ChIP-Seq_VCAP_Human1.21062986
78NANOG_19829295_ChIP-Seq_ESCs_Human1.20599790
79SOX2_19829295_ChIP-Seq_ESCs_Human1.20599790
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19398897
81TCF4_22108803_ChIP-Seq_LS180_Human1.17586896
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17440966
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16529132
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15781571
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.15465085
86TCF4_23295773_ChIP-Seq_U87_Human1.14362097
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13899354
88P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13875669
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13832439
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.13667959
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13305921
92RUNX2_22187159_ChIP-Seq_PCA_Human1.13189005
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12661470
94TP53_22573176_ChIP-Seq_HFKS_Human1.12176044
95* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12075544
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.11393167
97TP53_16413492_ChIP-PET_HCT116_Human1.11131472
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.11004483
99POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10141527
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.09731202
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.08743024
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08490071
103PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07589588
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.07418739
105* IRF1_19129219_ChIP-ChIP_H3396_Human1.07352639
106TAL1_26923725_Chip-Seq_HPCs_Mouse1.06533773
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.06214799
108MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06031330
109* SOX9_26525672_Chip-Seq_HEART_Mouse1.05635515
110* WT1_19549856_ChIP-ChIP_CCG9911_Human1.05329223
111KDM2B_26808549_Chip-Seq_REH_Human1.05282777
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05044296
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04981493
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04755072
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.04479885
116FLI1_27457419_Chip-Seq_LIVER_Mouse1.04120248
117P300_18555785_Chip-Seq_ESCs_Mouse1.04070828
118SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03491214
119P53_22387025_ChIP-Seq_ESCs_Mouse1.03333051
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02728961
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02034826
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.01614000
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00072698
124* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99947237
125OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99942137
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99303705
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99303705
128RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99064951
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98133991
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96859464
131TP53_18474530_ChIP-ChIP_U2OS_Human0.96665294
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96606353
133RING1B_27294783_Chip-Seq_ESCs_Mouse0.93551671
134AHR_22903824_ChIP-Seq_MCF-7_Human0.93388639
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92783706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.59591462
2MP0004859_abnormal_synaptic_plasticity3.82391729
3MP0004270_analgesia3.52269400
4MP0000569_abnormal_digit_pigmentation3.34763202
5MP0008877_abnormal_DNA_methylation3.21372906
6MP0003635_abnormal_synaptic_transmissio3.10241063
7MP0002735_abnormal_chemical_nociception2.89246889
8MP0001968_abnormal_touch/_nociception2.81014877
9MP0002064_seizures2.70056359
10MP0009745_abnormal_behavioral_response2.69804068
11MP0002272_abnormal_nervous_system2.67226498
12MP0009046_muscle_twitch2.65501769
13MP0002734_abnormal_mechanical_nocicepti2.60597393
14MP0006276_abnormal_autonomic_nervous2.59303143
15MP0001529_abnormal_vocalization2.51844242
16MP0001486_abnormal_startle_reflex2.49328328
17MP0002063_abnormal_learning/memory/cond2.48545158
18MP0002572_abnormal_emotion/affect_behav2.41326828
19MP0002736_abnormal_nociception_after2.39014844
20MP0005423_abnormal_somatic_nervous2.35480484
21MP0001905_abnormal_dopamine_level2.35138649
22MP0000778_abnormal_nervous_system2.34492543
23MP0001986_abnormal_taste_sensitivity2.24266239
24MP0003122_maternal_imprinting2.16189137
25MP0001984_abnormal_olfaction2.07430799
26MP0001970_abnormal_pain_threshold2.06665577
27MP0009780_abnormal_chondrocyte_physiolo2.06121428
28MP0001188_hyperpigmentation2.05910557
29MP0002733_abnormal_thermal_nociception2.05873891
30MP0003195_calcinosis2.03172143
31MP0005171_absent_coat_pigmentation1.97118727
32MP0002067_abnormal_sensory_capabilities1.92245619
33MP0005646_abnormal_pituitary_gland1.90640185
34MP0002184_abnormal_innervation1.80582332
35MP0001440_abnormal_grooming_behavior1.67808641
36MP0000920_abnormal_myelination1.64094801
37MP0004142_abnormal_muscle_tone1.62216821
38MP0005645_abnormal_hypothalamus_physiol1.59645440
39MP0002557_abnormal_social/conspecific_i1.55452572
40MP0004742_abnormal_vestibular_system1.54383683
41MP0008872_abnormal_physiological_respon1.51057168
42MP0002837_dystrophic_cardiac_calcinosis1.50995168
43MP0002822_catalepsy1.49013453
44MP0002882_abnormal_neuron_morphology1.48651115
45MP0004924_abnormal_behavior1.46957597
46MP0005386_behavior/neurological_phenoty1.46957597
47MP0004133_heterotaxia1.45208766
48MP0008569_lethality_at_weaning1.43230217
49MP0000955_abnormal_spinal_cord1.42939740
50MP0005551_abnormal_eye_electrophysiolog1.39834843
51MP0001501_abnormal_sleep_pattern1.38459997
52MP0003787_abnormal_imprinting1.35534036
53MP0005174_abnormal_tail_pigmentation1.33741124
54MP0002928_abnormal_bile_duct1.33504719
55MP0003879_abnormal_hair_cell1.32251669
56MP0008995_early_reproductive_senescence1.30848863
57MP0005409_darkened_coat_color1.29531747
58MP0004147_increased_porphyrin_level1.27683998
59MP0004811_abnormal_neuron_physiology1.26598217
60MP0002066_abnormal_motor_capabilities/c1.25972093
61MP0004134_abnormal_chest_morphology1.24498665
62MP0005084_abnormal_gallbladder_morpholo1.23300771
63MP0001963_abnormal_hearing_physiology1.21843993
64MP0002876_abnormal_thyroid_physiology1.21787837
65MP0003950_abnormal_plasma_membrane1.20752794
66MP0003329_amyloid_beta_deposits1.19555171
67MP0005389_reproductive_system_phenotype1.19264382
68MP0002752_abnormal_somatic_nervous1.16546166
69MP0002160_abnormal_reproductive_system1.14834552
70MP0004885_abnormal_endolymph1.14237933
71MP0002229_neurodegeneration1.14012273
72MP0004858_abnormal_nervous_system1.13419236
73MP0006072_abnormal_retinal_apoptosis1.13242908
74MP0003890_abnormal_embryonic-extraembry1.12999596
75MP0002163_abnormal_gland_morphology1.11057599
76MP0000631_abnormal_neuroendocrine_gland1.10858625
77MP0008260_abnormal_autophagy1.10271560
78MP0003634_abnormal_glial_cell1.08948484
79MP0010386_abnormal_urinary_bladder1.08102393
80MP0000427_abnormal_hair_cycle1.07795907
81MP0003724_increased_susceptibility_to1.06960536
82MP0003011_delayed_dark_adaptation1.04916099
83MP0002152_abnormal_brain_morphology1.03670772
84MP0002638_abnormal_pupillary_reflex1.03528699
85MP0003567_abnormal_fetal_cardiomyocyte1.03259636
86MP0003136_yellow_coat_color1.02766335
87MP0002751_abnormal_autonomic_nervous1.00634110
88MP0001485_abnormal_pinna_reflex1.00222862
89MP0005187_abnormal_penis_morphology1.00015209
90MP0000372_irregular_coat_pigmentation0.99550534
91MP0000026_abnormal_inner_ear0.98497026
92MP0002909_abnormal_adrenal_gland0.97320122
93MP0001919_abnormal_reproductive_system0.96007483
94MP0002938_white_spotting0.95303826
95MP0003646_muscle_fatigue0.94654073
96MP0005253_abnormal_eye_physiology0.94363450
97MP0002234_abnormal_pharynx_morphology0.91215355
98MP0003283_abnormal_digestive_organ0.90703579
99MP0001299_abnormal_eye_distance/0.90507676
100MP0002095_abnormal_skin_pigmentation0.90023274
101MP0002653_abnormal_ependyma_morphology0.89509679
102MP0003631_nervous_system_phenotype0.88792138
103MP0003938_abnormal_ear_development0.88610316
104MP0005075_abnormal_melanosome_morpholog0.86745284
105MP0003121_genomic_imprinting0.85832902
106MP0003183_abnormal_peptide_metabolism0.84278756
107MP0004043_abnormal_pH_regulation0.82175545
108MP0002102_abnormal_ear_morphology0.82097981
109MP0001502_abnormal_circadian_rhythm0.81965420
110MP0002332_abnormal_exercise_endurance0.81953936
111MP0003119_abnormal_digestive_system0.81773873
112MP0003633_abnormal_nervous_system0.81736513
113MP0001324_abnormal_eye_pigmentation0.81419205
114MP0004215_abnormal_myocardial_fiber0.80184252
115MP0005394_taste/olfaction_phenotype0.80170108
116MP0005499_abnormal_olfactory_system0.80170108
117MP0003632_abnormal_nervous_system0.76476426
118MP0008789_abnormal_olfactory_epithelium0.71998544
119MP0006292_abnormal_olfactory_placode0.67793373
120MP0000015_abnormal_ear_pigmentation0.66796720
121MP0000751_myopathy0.66124878
122MP0002069_abnormal_eating/drinking_beha0.65737740
123MP0000681_abnormal_thyroid_gland0.65327070
124MP0003861_abnormal_nervous_system0.64635729
125MP0004085_abnormal_heartbeat0.63798876
126MP0009250_abnormal_appendicular_skeleto0.63610825
127MP0005195_abnormal_posterior_eye0.62171420
128MP0001664_abnormal_digestion0.61938822
129MP0003690_abnormal_glial_cell0.60800768
130MP0005410_abnormal_fertilization0.59755722
131MP0001177_atelectasis0.59630613
132MP0004145_abnormal_muscle_electrophysio0.58085154

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.87617594
2Myokymia (HP:0002411)4.67090447
3Atonic seizures (HP:0010819)4.46287444
4Pancreatic cysts (HP:0001737)4.38338144
5True hermaphroditism (HP:0010459)4.15425711
6Epileptic encephalopathy (HP:0200134)4.08263725
7Pancreatic fibrosis (HP:0100732)3.98651498
8Febrile seizures (HP:0002373)3.90916386
9Abnormality of midbrain morphology (HP:0002418)3.89871772
10Molar tooth sign on MRI (HP:0002419)3.89871772
11Nephronophthisis (HP:0000090)3.83756324
12Focal seizures (HP:0007359)3.82455286
13Abnormal hair whorl (HP:0010721)3.66653442
14Progressive cerebellar ataxia (HP:0002073)3.46763262
15Limb dystonia (HP:0002451)3.39540116
16Abnormality of the renal medulla (HP:0100957)3.39235195
17Abnormality of the renal cortex (HP:0011035)3.36570992
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.34067721
19Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.34067721
20Hyperventilation (HP:0002883)3.26454492
21Gait imbalance (HP:0002141)3.19182529
22Abnormality of the corticospinal tract (HP:0002492)3.11746829
23Visual hallucinations (HP:0002367)3.11650185
24Medial flaring of the eyebrow (HP:0010747)3.07189571
25Pheochromocytoma (HP:0002666)3.04713141
26Genetic anticipation (HP:0003743)3.02491474
27Hypothermia (HP:0002045)3.00756480
28Congenital stationary night blindness (HP:0007642)3.00748760
29Absence seizures (HP:0002121)2.98047820
30Renal cortical cysts (HP:0000803)2.92814311
31Neuroendocrine neoplasm (HP:0100634)2.87558988
32Congenital primary aphakia (HP:0007707)2.86306284
33Ankle clonus (HP:0011448)2.84012239
34Nephrogenic diabetes insipidus (HP:0009806)2.82497957
35Abolished electroretinogram (ERG) (HP:0000550)2.79273814
36Retinal dysplasia (HP:0007973)2.73140918
37Acute necrotizing encephalopathy (HP:0006965)2.72215217
38Type II lissencephaly (HP:0007260)2.71422581
39Dialeptic seizures (HP:0011146)2.69995402
40Sensory axonal neuropathy (HP:0003390)2.67117720
41Vaginal atresia (HP:0000148)2.60265497
42Genital tract atresia (HP:0001827)2.59823430
43Cystic liver disease (HP:0006706)2.59077010
44Methylmalonic acidemia (HP:0002912)2.57822006
45Dysmetria (HP:0001310)2.56410701
46Supranuclear gaze palsy (HP:0000605)2.56218490
47White forelock (HP:0002211)2.51543937
48Fair hair (HP:0002286)2.50205717
49Termporal pattern (HP:0011008)2.48792906
50Insidious onset (HP:0003587)2.48792906
51Broad-based gait (HP:0002136)2.46248082
52Polyphagia (HP:0002591)2.42047515
53Increased serum pyruvate (HP:0003542)2.40166227
54Abnormality of glycolysis (HP:0004366)2.40166227
55Abnormal mitochondria in muscle tissue (HP:0008316)2.39433426
56Patchy hypopigmentation of hair (HP:0011365)2.38868885
57Chronic hepatic failure (HP:0100626)2.37766572
58Progressive macrocephaly (HP:0004481)2.37338879
59Specific learning disability (HP:0001328)2.35849717
60Scanning speech (HP:0002168)2.31789087
61Truncal ataxia (HP:0002078)2.28777673
62Spastic gait (HP:0002064)2.27766441
63Esotropia (HP:0000565)2.27347619
64Generalized tonic-clonic seizures (HP:0002069)2.27258323
65Narrow nasal bridge (HP:0000446)2.26823112
66Attenuation of retinal blood vessels (HP:0007843)2.24620093
67Protruding tongue (HP:0010808)2.23086166
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.22752746
69Progressive inability to walk (HP:0002505)2.22548914
70Drooling (HP:0002307)2.21586420
71Excessive salivation (HP:0003781)2.21586420
72Action tremor (HP:0002345)2.20462806
73Furrowed tongue (HP:0000221)2.18346551
74Volvulus (HP:0002580)2.16535283
75Lower limb muscle weakness (HP:0007340)2.16064450
76Pachygyria (HP:0001302)2.15036071
77Abnormality of alanine metabolism (HP:0010916)2.15027540
78Hyperalaninemia (HP:0003348)2.15027540
79Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15027540
80Neurofibrillary tangles (HP:0002185)2.14533377
81Inability to walk (HP:0002540)2.14073334
82Decreased central vision (HP:0007663)2.12210887
83Abnormal drinking behavior (HP:0030082)2.11449334
84Polydipsia (HP:0001959)2.11449334
85Sclerocornea (HP:0000647)2.10994607
86Poor coordination (HP:0002370)2.10528040
87Thickened helices (HP:0000391)2.09418027
88Abnormality of salivation (HP:0100755)2.07578108
89Anencephaly (HP:0002323)2.07461631
90Mitochondrial inheritance (HP:0001427)2.07227518
91Male pseudohermaphroditism (HP:0000037)2.05289179
92Congenital sensorineural hearing impairment (HP:0008527)2.04223838
93Amblyopia (HP:0000646)2.03572119
94Aplasia/Hypoplasia of the lens (HP:0008063)2.03417707
95Aplasia/Hypoplasia of the spleen (HP:0010451)2.02770490
96Abnormal eating behavior (HP:0100738)2.01223792
97Tubular atrophy (HP:0000092)2.01144201
98Generalized hypopigmentation of hair (HP:0011358)2.00897904
99Intestinal atresia (HP:0011100)2.00810376
100Gaze-evoked nystagmus (HP:0000640)2.00384090
101Asplenia (HP:0001746)1.98754494
102Pendular nystagmus (HP:0012043)1.97690250
103Absent speech (HP:0001344)1.97481429
104Stomach cancer (HP:0012126)1.96963275
105Poor suck (HP:0002033)1.96506600
106Increased corneal curvature (HP:0100692)1.96075220
107Keratoconus (HP:0000563)1.96075220
108Abnormal rod and cone electroretinograms (HP:0008323)1.95073461
109Optic disc pallor (HP:0000543)1.95035326
110Anxiety (HP:0000739)1.94252732
111Postaxial foot polydactyly (HP:0001830)1.93741164
112Leukodystrophy (HP:0002415)1.92923899
113Blue irides (HP:0000635)1.92071725
114Optic nerve hypoplasia (HP:0000609)1.90833487
115Poor speech (HP:0002465)1.90436657
116Postaxial hand polydactyly (HP:0001162)1.89749417
117Hemiparesis (HP:0001269)1.89618481
118Aplasia/Hypoplasia of the tibia (HP:0005772)1.88995516
119Congenital hepatic fibrosis (HP:0002612)1.88660054
120Heterochromia iridis (HP:0001100)1.88610991
121Hepatocellular necrosis (HP:0001404)1.87414017
122Chorioretinal atrophy (HP:0000533)1.87037183
123Peripheral hypomyelination (HP:0007182)1.86919003
124Akinesia (HP:0002304)1.86066640
125Broad foot (HP:0001769)1.85869381
126Widely spaced teeth (HP:0000687)1.85439895
127Lissencephaly (HP:0001339)1.85001863
128Impaired vibration sensation in the lower limbs (HP:0002166)1.84755993
129Decreased circulating renin level (HP:0003351)1.83380107
130Acute encephalopathy (HP:0006846)1.83272061
131Methylmalonic aciduria (HP:0012120)1.83184062
132Cerebral hypomyelination (HP:0006808)1.82895541
133Failure to thrive in infancy (HP:0001531)1.82830812
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82120524
135Aplasia/Hypoplasia of the brainstem (HP:0007362)1.81712745
136Hypoplasia of the brainstem (HP:0002365)1.81712745
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81664146
138Thyroid-stimulating hormone excess (HP:0002925)1.81637639
139Narrow forehead (HP:0000341)1.81303058
140Abnormal respiratory motile cilium morphology (HP:0005938)1.79682609
141Abnormal respiratory epithelium morphology (HP:0012253)1.79682609
142Xerostomia (HP:0000217)1.79561482
143Psychosis (HP:0000709)1.77838193
144Fetal akinesia sequence (HP:0001989)1.76950403
145Aplasia involving bones of the extremities (HP:0009825)1.75711818
146Aplasia involving bones of the upper limbs (HP:0009823)1.75711818
147Aplasia of the phalanges of the hand (HP:0009802)1.75711818
148Abnormality of vitamin B metabolism (HP:0004340)1.75414995
149Parakeratosis (HP:0001036)1.75305473
150Hypochromic microcytic anemia (HP:0004840)1.74802770
151Oligodactyly (hands) (HP:0001180)1.74797104
152Absent/shortened dynein arms (HP:0200106)1.74787604
153Dynein arm defect of respiratory motile cilia (HP:0012255)1.74787604
154Epileptiform EEG discharges (HP:0011182)1.74572126
155Abnormality of the labia minora (HP:0012880)1.72945449
156Bony spicule pigmentary retinopathy (HP:0007737)1.72295701
157Short foot (HP:0001773)1.72290505
158Abnormality of the vitamin B12 metabolism (HP:0004341)1.72259586
159Dysdiadochokinesis (HP:0002075)1.72231447
160Agitation (HP:0000713)1.70825712
161Tented upper lip vermilion (HP:0010804)1.70768372
162Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.70042880
163Urinary urgency (HP:0000012)1.68308431
164Exotropia (HP:0000577)1.66688570
165Polyuria (HP:0000103)1.66404504
166Autoamputation (HP:0001218)1.66031546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.52476923
2CASK4.40129622
3MAP4K23.50598666
4MAP3K123.43490986
5MAP2K73.23756733
6TNIK3.05331861
7MARK12.69454784
8NTRK32.66734402
9MAP3K42.65862331
10CDK192.37655488
11SIK32.28208712
12PRPF4B2.26294493
13TAOK32.24252416
14EPHA42.10183583
15NEK12.07333361
16OXSR12.02514998
17NUAK11.91508025
18PINK11.88963644
19STK391.87251161
20MAPK131.84355076
21GRK11.82471000
22MINK11.81168801
23AKT31.78763143
24TRIM281.76728290
25BCR1.71158632
26GRK51.69261970
27MAP3K91.67103124
28PLK21.62245748
29DYRK21.51848140
30LIMK11.49425125
31MAP2K41.47618390
32MAPKAPK51.45006112
33ACVR1B1.43985001
34NTRK21.42940782
35UHMK11.40899252
36TXK1.38139157
37CSNK1G31.36796514
38SGK4941.34224356
39SGK2231.34224356
40CSNK1G21.31121826
41ARAF1.28992413
42INSRR1.28058141
43PNCK1.23146048
44BMPR21.22040251
45PAK61.19783118
46CDK51.16802946
47DAPK11.13643404
48MUSK1.09633658
49CSNK1A1L1.07698965
50GRK71.05333769
51DAPK21.04585404
52CAMK2B1.01813813
53BMPR1B1.01543811
54ZAK1.01158311
55PRKCG0.99897172
56PRKCE0.99781956
57CDK180.98103515
58STK38L0.96682100
59YES10.94906752
60CCNB10.93538258
61CAMK2A0.93457276
62CDK140.93054003
63FGFR20.92616467
64TLK10.91246085
65NTRK10.88124802
66CDK150.87366776
67KSR10.86456687
68RIPK40.80780843
69CAMKK20.79732090
70CDK11A0.79358118
71CSNK1G10.79076417
72ADRBK20.78368560
73CDK80.77983627
74WNK30.76596661
75BRSK20.75472636
76TIE10.69725526
77NEK20.69448745
78PKN10.69242669
79DYRK30.68791243
80DYRK1A0.65308296
81SGK20.64964756
82MARK20.63387432
83CAMK2D0.63372790
84GRK60.62690594
85TYRO30.62389326
86NEK60.62137078
87TSSK60.62073832
88TAF10.59914681
89ERBB20.58650894
90PAK30.58646212
91ADRBK10.58379963
92CAMK40.57167025
93TEC0.56265832
94TNK20.55518778
95ERBB30.55186527
96CDK30.54791041
97MKNK10.54107989
98SYK0.53904553
99ROCK20.53440191
100PHKG20.53195615
101PHKG10.53195615
102FGR0.53169410
103CAMK10.52795442
104TAOK20.52086636
105MKNK20.51906407
106PTK2B0.50017408
107CSNK1D0.49730420
108BRAF0.48621091
109IRAK20.48308228
110FES0.48298612
111IKBKE0.47904153
112SIK20.47754994
113VRK10.47577184
114EPHB10.47315466
115PLK30.46669752
116MST40.46163026
117MAP3K60.44793942
118CSNK1A10.44764783
119CAMK2G0.44372942
120STK160.43276617
121WNK40.42774446
122EPHA30.42469212
123STK110.40120970
124ITK0.39325300
125WNK10.39316159
126FYN0.39247361
127STK30.38567362
128PRKCZ0.38548014
129MATK0.38190137
130MYLK0.36532241
131IRAK10.36039669
132PIK3CA0.35075218
133MAP2K60.34950502
134EPHB20.34792689
135PRKACA0.34684860
136MAPK70.34602224
137PRKG10.33662190
138PRKCQ0.33604876
139IGF1R0.32944638
140RPS6KA50.32490244
141EGFR0.32125086
142PRKACB0.32026097

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.43285124
2Synaptic vesicle cycle_Homo sapiens_hsa047213.23687152
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63129649
4Collecting duct acid secretion_Homo sapiens_hsa049662.56528639
5Oxidative phosphorylation_Homo sapiens_hsa001902.45987809
6GABAergic synapse_Homo sapiens_hsa047272.45135483
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.43617503
8Glutamatergic synapse_Homo sapiens_hsa047242.33705842
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.31957445
10Morphine addiction_Homo sapiens_hsa050322.31124932
11Linoleic acid metabolism_Homo sapiens_hsa005912.29619807
12Butanoate metabolism_Homo sapiens_hsa006502.28269746
13Olfactory transduction_Homo sapiens_hsa047402.27393291
14Nitrogen metabolism_Homo sapiens_hsa009102.24795571
15Phototransduction_Homo sapiens_hsa047442.23537141
16Circadian entrainment_Homo sapiens_hsa047132.22527219
17Serotonergic synapse_Homo sapiens_hsa047262.22130839
18Dopaminergic synapse_Homo sapiens_hsa047282.09009052
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.97606481
20Parkinsons disease_Homo sapiens_hsa050121.91894301
21Taste transduction_Homo sapiens_hsa047421.90540699
22Amphetamine addiction_Homo sapiens_hsa050311.87160689
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.84205855
24Vibrio cholerae infection_Homo sapiens_hsa051101.79559028
25Long-term potentiation_Homo sapiens_hsa047201.79093655
26Axon guidance_Homo sapiens_hsa043601.75124392
27Cholinergic synapse_Homo sapiens_hsa047251.69467097
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68388601
29Cocaine addiction_Homo sapiens_hsa050301.65051495
30Alzheimers disease_Homo sapiens_hsa050101.64210951
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64035385
32Long-term depression_Homo sapiens_hsa047301.61054113
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53582985
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.45473036
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.42311151
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.38354036
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35665757
38Tryptophan metabolism_Homo sapiens_hsa003801.34710242
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34402228
40Insulin secretion_Homo sapiens_hsa049111.33960235
41Salivary secretion_Homo sapiens_hsa049701.29695210
42Propanoate metabolism_Homo sapiens_hsa006401.26753594
43Huntingtons disease_Homo sapiens_hsa050161.22220260
44Rheumatoid arthritis_Homo sapiens_hsa053231.21150117
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17884502
46Renin secretion_Homo sapiens_hsa049241.14290917
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13591675
48Caffeine metabolism_Homo sapiens_hsa002321.11367555
49Primary bile acid biosynthesis_Homo sapiens_hsa001201.10861636
50Cardiac muscle contraction_Homo sapiens_hsa042601.10109707
51Calcium signaling pathway_Homo sapiens_hsa040201.09634408
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08584986
53Gap junction_Homo sapiens_hsa045401.07347557
54Circadian rhythm_Homo sapiens_hsa047101.04692684
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04674271
56RNA degradation_Homo sapiens_hsa030181.03988814
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03958736
58Oxytocin signaling pathway_Homo sapiens_hsa049211.03191616
59Fatty acid elongation_Homo sapiens_hsa000621.01439697
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00577968
61Ether lipid metabolism_Homo sapiens_hsa005650.96930392
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96513946
63Steroid biosynthesis_Homo sapiens_hsa001000.94343116
64ErbB signaling pathway_Homo sapiens_hsa040120.93448941
65Gastric acid secretion_Homo sapiens_hsa049710.92424982
66Ras signaling pathway_Homo sapiens_hsa040140.91234975
67Selenocompound metabolism_Homo sapiens_hsa004500.89956998
68ABC transporters_Homo sapiens_hsa020100.88870583
69GnRH signaling pathway_Homo sapiens_hsa049120.88246053
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87486342
71Phagosome_Homo sapiens_hsa041450.86106699
72Fanconi anemia pathway_Homo sapiens_hsa034600.84351516
73cAMP signaling pathway_Homo sapiens_hsa040240.84169900
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83113419
75Peroxisome_Homo sapiens_hsa041460.80418815
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.80115045
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80034929
78Melanogenesis_Homo sapiens_hsa049160.78959314
79Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74572239
80Homologous recombination_Homo sapiens_hsa034400.73334648
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.72123681
82Chemical carcinogenesis_Homo sapiens_hsa052040.72072149
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.71874029
84RNA polymerase_Homo sapiens_hsa030200.70576315
85Alcoholism_Homo sapiens_hsa050340.69477380
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69412521
87MAPK signaling pathway_Homo sapiens_hsa040100.69405523
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68774771
89Retinol metabolism_Homo sapiens_hsa008300.68397560
90Regulation of autophagy_Homo sapiens_hsa041400.64266486
91Arachidonic acid metabolism_Homo sapiens_hsa005900.62312084
92Renal cell carcinoma_Homo sapiens_hsa052110.62229145
93Primary immunodeficiency_Homo sapiens_hsa053400.61867782
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61614732
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61456208
96Histidine metabolism_Homo sapiens_hsa003400.61270538
97Wnt signaling pathway_Homo sapiens_hsa043100.60870819
98Protein export_Homo sapiens_hsa030600.59429093
99Oocyte meiosis_Homo sapiens_hsa041140.58926687
100beta-Alanine metabolism_Homo sapiens_hsa004100.57745131
101Glycerolipid metabolism_Homo sapiens_hsa005610.57652304
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57223716
103Rap1 signaling pathway_Homo sapiens_hsa040150.57126766
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.56133178
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55823112
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55437386
107Choline metabolism in cancer_Homo sapiens_hsa052310.54422702
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54128046
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.53752351
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51997490
111Sphingolipid metabolism_Homo sapiens_hsa006000.51547195
112Endocytosis_Homo sapiens_hsa041440.50321091
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48260266
114Melanoma_Homo sapiens_hsa052180.48026368
115Proteasome_Homo sapiens_hsa030500.47218285
116Vitamin digestion and absorption_Homo sapiens_hsa049770.47133698
117Estrogen signaling pathway_Homo sapiens_hsa049150.46572425
118Fat digestion and absorption_Homo sapiens_hsa049750.46351814
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.44828084
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44383104
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.43854489
122Hedgehog signaling pathway_Homo sapiens_hsa043400.42576590
123Glioma_Homo sapiens_hsa052140.42287376
124Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41597592
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.39026098
126Type II diabetes mellitus_Homo sapiens_hsa049300.38481461
127Colorectal cancer_Homo sapiens_hsa052100.37293583
128Ovarian steroidogenesis_Homo sapiens_hsa049130.36751527
129Mineral absorption_Homo sapiens_hsa049780.36698022
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36634726
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36217981
132Asthma_Homo sapiens_hsa053100.35483255
133African trypanosomiasis_Homo sapiens_hsa051430.34548151
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33113113
135Dorso-ventral axis formation_Homo sapiens_hsa043200.31734051
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31534628
137Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30937904
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.29090312
139Fatty acid biosynthesis_Homo sapiens_hsa000610.28059348
140Type I diabetes mellitus_Homo sapiens_hsa049400.25986494
141Basal transcription factors_Homo sapiens_hsa030220.25964400
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25751059
143Dilated cardiomyopathy_Homo sapiens_hsa054140.25383603
144Salmonella infection_Homo sapiens_hsa051320.24370241
145Shigellosis_Homo sapiens_hsa051310.21080031
146Chemokine signaling pathway_Homo sapiens_hsa040620.21075322

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