RAB24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)9.36810938
2translational termination (GO:0006415)8.97830067
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.92288126
4ribosomal small subunit assembly (GO:0000028)7.84604996
5cotranslational protein targeting to membrane (GO:0006613)7.83104719
6protein targeting to ER (GO:0045047)7.80275000
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.50353215
8translational elongation (GO:0006414)7.49307716
9protein localization to endoplasmic reticulum (GO:0070972)7.48122237
10ribosomal small subunit biogenesis (GO:0042274)7.09822609
11viral life cycle (GO:0019058)6.95136672
12cellular protein complex disassembly (GO:0043624)6.70475210
13DNA deamination (GO:0045006)6.50051742
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.48776825
15translational initiation (GO:0006413)5.97702603
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.95891263
17negative regulation of cell killing (GO:0031342)5.95891263
18protein complex disassembly (GO:0043241)5.74507552
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49444242
20positive regulation by organism of defense response of other organism involved in symbiotic interact5.49444242
21modulation by symbiont of host immune response (GO:0052553)5.49444242
22positive regulation by symbiont of host defense response (GO:0052509)5.49444242
23modulation by symbiont of host defense response (GO:0052031)5.49444242
24modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49444242
25macromolecular complex disassembly (GO:0032984)5.43129103
26protein targeting to membrane (GO:0006612)5.40154310
27positive regulation of gamma-delta T cell activation (GO:0046645)5.39711586
28neutrophil activation involved in immune response (GO:0002283)5.27092834
29detection of other organism (GO:0098543)5.23750748
30detection of bacterium (GO:0016045)5.16329163
31antigen processing and presentation of endogenous antigen (GO:0019883)5.13691483
32response to peptidoglycan (GO:0032494)4.97075387
33maturation of SSU-rRNA (GO:0030490)4.96407556
34antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.91124109
35ribosomal large subunit biogenesis (GO:0042273)4.76216379
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.67589210
37macrophage activation involved in immune response (GO:0002281)4.64606400
38immunoglobulin mediated immune response (GO:0016064)4.42083652
39detection of external biotic stimulus (GO:0098581)4.41745916
40translation (GO:0006412)4.41349198
41leukocyte aggregation (GO:0070486)4.36157720
42nuclear-transcribed mRNA catabolic process (GO:0000956)4.29760070
43antigen processing and presentation via MHC class Ib (GO:0002475)4.25934512
44negative regulation of interleukin-12 production (GO:0032695)4.23022100
45regulation of B cell receptor signaling pathway (GO:0050855)4.19216385
46energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17712099
47ATP synthesis coupled proton transport (GO:0015986)4.17712099
48neutrophil activation (GO:0042119)4.17353371
49leukocyte migration involved in inflammatory response (GO:0002523)4.12843257
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.12308491
51mRNA catabolic process (GO:0006402)4.04896710
52detection of molecule of bacterial origin (GO:0032490)4.04524325
53respiratory burst (GO:0045730)3.96164582
54establishment of protein localization to membrane (GO:0090150)3.93513798
55positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.92835635
56granulocyte activation (GO:0036230)3.89746364
57regulation of interferon-beta biosynthetic process (GO:0045357)3.87861054
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87462920
59response to host immune response (GO:0052572)3.87462920
60platelet dense granule organization (GO:0060155)3.87060130
61negative regulation of lymphocyte mediated immunity (GO:0002707)3.85790023
62regulation of gamma-delta T cell activation (GO:0046643)3.85391351
63detection of biotic stimulus (GO:0009595)3.84055228
64ncRNA 3-end processing (GO:0043628)3.77871760
65regulation of mast cell degranulation (GO:0043304)3.77428575
66protein targeting (GO:0006605)3.75864425
67type I interferon signaling pathway (GO:0060337)3.74679551
68cellular response to type I interferon (GO:0071357)3.74679551
69response to type I interferon (GO:0034340)3.71171685
70RNA catabolic process (GO:0006401)3.66427361
71positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64418960
72negative regulation of erythrocyte differentiation (GO:0045647)3.61908693
73cellular extravasation (GO:0045123)3.59438133
74myeloid cell activation involved in immune response (GO:0002275)3.57945596
75negative regulation of leukocyte mediated immunity (GO:0002704)3.57020857
76respiratory electron transport chain (GO:0022904)3.50549378
77regulation of myeloid leukocyte mediated immunity (GO:0002886)3.48041283
78electron transport chain (GO:0022900)3.46702337
79response to host (GO:0075136)3.46594933
80response to host defenses (GO:0052200)3.46594933
81response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.46594933
82interferon-gamma-mediated signaling pathway (GO:0060333)3.44890025
83response to muramyl dipeptide (GO:0032495)3.43966904
84microglial cell activation (GO:0001774)3.43636982
85macrophage activation (GO:0042116)3.43606318
86neutrophil mediated immunity (GO:0002446)3.42256568
87ribonucleoprotein complex biogenesis (GO:0022613)3.41742588
88establishment of protein localization to organelle (GO:0072594)3.39188214
89regulation of mast cell activation involved in immune response (GO:0033006)3.38189945
90regulation of T-helper 2 cell differentiation (GO:0045628)3.37423463
91heme biosynthetic process (GO:0006783)3.34738957
92defense response to protozoan (GO:0042832)3.30134263
93protein localization to membrane (GO:0072657)3.29228315
94regulation of leukocyte degranulation (GO:0043300)3.28539990
95B cell mediated immunity (GO:0019724)3.28254108
96response to interleukin-15 (GO:0070672)3.26921347
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.25719331
98negative regulation of T cell mediated immunity (GO:0002710)3.24703257
99pseudouridine synthesis (GO:0001522)3.24331359
100negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19794672
101metallo-sulfur cluster assembly (GO:0031163)3.19054462
102iron-sulfur cluster assembly (GO:0016226)3.19054462
103positive regulation of mast cell activation (GO:0033005)3.17925372
104regulation of gamma-delta T cell differentiation (GO:0045586)3.17519525
105lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16252246
106B cell receptor signaling pathway (GO:0050853)3.15516892
107regulation of T cell tolerance induction (GO:0002664)3.12498441
108regulation of mast cell activation (GO:0033003)3.12188841
109leukocyte degranulation (GO:0043299)3.11035335
110production of molecular mediator involved in inflammatory response (GO:0002532)3.09439445
111protein maturation by protein folding (GO:0022417)3.08654073
112inner mitochondrial membrane organization (GO:0007007)3.07343045
113germinal center formation (GO:0002467)3.06091155
114regulation of T cell mediated cytotoxicity (GO:0001914)3.05506897
115cellular component biogenesis (GO:0044085)3.05328663
116negative regulation of cytokine production involved in immune response (GO:0002719)3.05317849
117cellular response to interleukin-15 (GO:0071350)3.04170595
118regulation of dendritic cell antigen processing and presentation (GO:0002604)3.02965573
119lymphoid progenitor cell differentiation (GO:0002320)3.02322079
120negative regulation of type 2 immune response (GO:0002829)3.00655497
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.99561245
122antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.99561245
123regulation of axon regeneration (GO:0048679)2.98876659
124regulation of neuron projection regeneration (GO:0070570)2.98876659
125negative regulation of innate immune response (GO:0045824)2.98618877
126regulation of regulated secretory pathway (GO:1903305)2.97606108
127myeloid leukocyte mediated immunity (GO:0002444)2.97497468
128pentose-phosphate shunt (GO:0006098)2.97308805
129regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.97213116
130regulation of B cell differentiation (GO:0045577)2.96059645
131regulation of tolerance induction (GO:0002643)2.94954850
132response to protozoan (GO:0001562)2.93684839
133positive regulation of T cell mediated cytotoxicity (GO:0001916)2.93403636
134positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91213711
135positive regulation of type 2 immune response (GO:0002830)2.88356087
136regulation of antigen processing and presentation (GO:0002577)2.87639017
137termination of RNA polymerase III transcription (GO:0006386)2.87158137
138transcription elongation from RNA polymerase III promoter (GO:0006385)2.87158137
139positive regulation of cellular amide metabolic process (GO:0034250)2.86649206
140positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.86119772
141response to interferon-beta (GO:0035456)2.85284725
142regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.85213986
143negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.84980708
144protein complex biogenesis (GO:0070271)2.84223915
145mitochondrial respiratory chain complex assembly (GO:0033108)2.83840279
146positive thymic T cell selection (GO:0045059)2.82815168
147positive regulation of mast cell activation involved in immune response (GO:0033008)2.82487204
148positive regulation of mast cell degranulation (GO:0043306)2.82487204
149regulation of type 2 immune response (GO:0002828)2.80567767
150quinone biosynthetic process (GO:1901663)2.80205022
151ubiquinone biosynthetic process (GO:0006744)2.80205022
152regulation of mitochondrial translation (GO:0070129)2.77786800
153negative regulation of interleukin-6 production (GO:0032715)2.77747363
154positive regulation of B cell differentiation (GO:0045579)2.77519789
155myeloid leukocyte activation (GO:0002274)2.76266694
156positive regulation of antigen processing and presentation (GO:0002579)2.75722070
157respiratory chain complex IV assembly (GO:0008535)2.75348227
158GDP-mannose metabolic process (GO:0019673)2.73825368
159negative regulation of glycoprotein biosynthetic process (GO:0010561)2.72825699
160mucosal-associated lymphoid tissue development (GO:0048537)2.70417510
161Peyers patch development (GO:0048541)2.70417510
162positive regulation of cellular amine metabolic process (GO:0033240)2.69041079
163regulation of regulatory T cell differentiation (GO:0045589)2.66751363
164anterograde synaptic vesicle transport (GO:0048490)2.64582733
165regulation of oxidative phosphorylation (GO:0002082)2.64205282
166regulation of respiratory burst (GO:0060263)2.62631638
167endosome to melanosome transport (GO:0035646)2.60165150
168endosome to pigment granule transport (GO:0043485)2.60165150
169DNA damage response, detection of DNA damage (GO:0042769)2.59808223
170rRNA processing (GO:0006364)2.58962794
171pteridine-containing compound biosynthetic process (GO:0042559)2.57930246
172protein targeting to mitochondrion (GO:0006626)2.57823679
173mitochondrial respiratory chain complex I assembly (GO:0032981)2.54037350
174NADH dehydrogenase complex assembly (GO:0010257)2.54037350
175mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.54037350
176heme metabolic process (GO:0042168)2.51754428
177nucleoside salvage (GO:0043174)2.50072677
178Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49855685
179CTP biosynthetic process (GO:0006241)2.48240222
180CTP metabolic process (GO:0046036)2.48240222
181negative regulation of transcription by competitive promoter binding (GO:0010944)2.47445848
182negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.46701502
183GTP biosynthetic process (GO:0006183)2.44292071
184neuronal action potential propagation (GO:0019227)2.44178682
185rRNA metabolic process (GO:0016072)2.43290052
186mature B cell differentiation involved in immune response (GO:0002313)2.43260698
187tRNA methylation (GO:0030488)2.43240617
188purine-containing compound salvage (GO:0043101)2.42100647
189NADPH regeneration (GO:0006740)2.41979656
190establishment of protein localization to mitochondrion (GO:0072655)2.37776881
191fucosylation (GO:0036065)2.37514578
192galactose catabolic process (GO:0019388)2.37331634
193pyrimidine nucleoside salvage (GO:0043097)2.36032764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.56721320
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.31398738
3* SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.77075640
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72988008
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.44809950
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.96375647
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.84339564
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79767349
9TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.77708986
10VDR_21846776_ChIP-Seq_THP-1_Human2.77586190
11SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65619666
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.59444632
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.55158713
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.52146692
15SCL_19346495_ChIP-Seq_HPC-7_Human2.48043159
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.45893974
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44628219
18FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.43851343
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.42978065
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41143392
21* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.35098501
22SRY_22984422_ChIP-ChIP_TESTIS_Rat2.34883473
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.34758646
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31079941
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.27444483
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.26285616
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23804986
28SPI1_23127762_ChIP-Seq_K562_Human2.22906730
29XRN2_22483619_ChIP-Seq_HELA_Human2.16638065
30MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16337369
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.10643446
32GATA1_22025678_ChIP-Seq_K562_Human2.07180426
33* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.03225543
34STAT4_19710469_ChIP-ChIP_TH1__Mouse2.00392374
35ERG_20887958_ChIP-Seq_HPC-7_Mouse2.00319503
36PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99263928
37DCP1A_22483619_ChIP-Seq_HELA_Human1.93215732
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89916584
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89369080
40MYC_22102868_ChIP-Seq_BL_Human1.88316973
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.87654576
42VDR_23849224_ChIP-Seq_CD4+_Human1.86888872
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85067810
44LXR_22292898_ChIP-Seq_THP-1_Human1.83941899
45CIITA_25753668_ChIP-Seq_RAJI_Human1.82893488
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.82819437
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.82739660
48LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82505468
49RUNX_20019798_ChIP-Seq_JUKART_Human1.75887618
50MYB_26560356_Chip-Seq_TH2_Human1.74769619
51* VDR_24763502_ChIP-Seq_THP-1_Human1.73415800
52CREB1_15753290_ChIP-ChIP_HEK293T_Human1.68271298
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67907809
54SPI1_23547873_ChIP-Seq_NB4_Human1.67488869
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.66881180
56* GABP_19822575_ChIP-Seq_HepG2_Human1.65055123
57TTF2_22483619_ChIP-Seq_HELA_Human1.64107858
58FOXP3_21729870_ChIP-Seq_TREG_Human1.63973673
59GATA1_22383799_ChIP-Seq_G1ME_Mouse1.62849439
60TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61476564
61GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.59599900
62MYC_19030024_ChIP-ChIP_MESCs_Mouse1.58191718
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.55659204
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.55495878
65* MYB_26560356_Chip-Seq_TH1_Human1.54699613
66* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.53837298
67BCOR_27268052_Chip-Seq_Bcells_Human1.53426538
68CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53021687
69FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.52577248
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50105118
71E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48909505
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48504013
73PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45838156
74KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45586777
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.45518751
76* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45396147
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45282598
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44130098
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43812789
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43751642
81ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41876851
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40941705
83MYB_21317192_ChIP-Seq_ERMYB_Mouse1.40109970
84PU.1_20513432_ChIP-Seq_Bcells_Mouse1.39756882
85SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39216954
86P68_20966046_ChIP-Seq_HELA_Human1.38432848
87IKZF1_21737484_ChIP-ChIP_HCT116_Human1.36347681
88TCF7_22412390_ChIP-Seq_EML_Mouse1.34164851
89MAF_26560356_Chip-Seq_TH1_Human1.33810467
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.33051466
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31918169
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31684192
93E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30709805
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30420060
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.29544701
96* UTX_26944678_Chip-Seq_JUKART_Human1.28180408
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.27699639
98SA1_27219007_Chip-Seq_ERYTHROID_Human1.26322951
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.25997129
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.25611169
101RACK7_27058665_Chip-Seq_MCF-7_Human1.24648222
102ZNF263_19887448_ChIP-Seq_K562_Human1.24327038
103MAF_26560356_Chip-Seq_TH2_Human1.22899021
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22533368
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22122591
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21458002
107CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21068579
108HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20674464
109EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20244783
110* BCL6_27268052_Chip-Seq_Bcells_Human1.19638669
111GATA3_27048872_Chip-Seq_THYMUS_Human1.19059477
112YY1_22570637_ChIP-Seq_MALME-3M_Human1.16464550
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16430754
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.14412395
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.13959965
116SA1_27219007_Chip-Seq_Bcells_Human1.13579230
117ELK3_25401928_ChIP-Seq_HUVEC_Human1.13395352
118NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13041032
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12716703
120FOXP1_21924763_ChIP-Seq_HESCs_Human1.12188752
121KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11014201
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10974672
123CTCF_26484167_Chip-Seq_Bcells_Mouse1.10309107
124* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09852430
125NCOR1_26117541_ChIP-Seq_K562_Human1.09836149
126CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08635905
127SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07221190
128GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06924000
129* SMC4_20622854_ChIP-Seq_HELA_Human1.06030501
130GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05684251
131TET1_21451524_ChIP-Seq_MESCs_Mouse1.05323574
132CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04777102
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.04482758
134* VDR_24787735_ChIP-Seq_THP-1_Human1.04313228
135ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03609287
136BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03253633
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02539668
138GATA1_19941826_ChIP-Seq_K562_Human1.02347744
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02291999
140E2F1_20622854_ChIP-Seq_HELA_Human1.02258678
141YY1_21170310_ChIP-Seq_MESCs_Mouse1.01432630
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01214735
143ELF1_20517297_ChIP-Seq_JURKAT_Human1.00933916
144KDM2B_26808549_Chip-Seq_DND41_Human1.00840804
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00334288
146CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.00296601
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.99591289
148SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97524472
149* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97130968
150* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95112776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.94449469
2MP0005174_abnormal_tail_pigmentation2.84183970
3MP0006082_CNS_inflammation2.81279025
4MP0000685_abnormal_immune_system2.67394002
5MP0008260_abnormal_autophagy2.48662274
6MP0006036_abnormal_mitochondrial_physio2.44944642
7MP0003656_abnormal_erythrocyte_physiolo2.39212867
8MP0005075_abnormal_melanosome_morpholog2.32228315
9MP0003866_abnormal_defecation2.29095725
10MP0003191_abnormal_cellular_cholesterol2.26928346
11MP0003329_amyloid_beta_deposits2.16084000
12MP0003436_decreased_susceptibility_to2.15498350
13MP0001533_abnormal_skeleton_physiology2.14005879
14MP0005671_abnormal_response_to2.07779749
15MP0009840_abnormal_foam_cell2.06354983
16MP0002909_abnormal_adrenal_gland2.04525689
17MP0004381_abnormal_hair_follicle2.01036411
18MP0005451_abnormal_body_composition1.85643783
19MP0009785_altered_susceptibility_to1.82169758
20MP0000465_gastrointestinal_hemorrhage1.79527802
21MP0002796_impaired_skin_barrier1.79424784
22MP0002405_respiratory_system_inflammati1.78585152
23MP0003724_increased_susceptibility_to1.72687488
24MP0003183_abnormal_peptide_metabolism1.72638624
25MP0005025_abnormal_response_to1.72499283
26MP0006035_abnormal_mitochondrial_morpho1.71292706
27MP0003880_abnormal_central_pattern1.70638045
28MP0009278_abnormal_bone_marrow1.67400762
29MP0001835_abnormal_antigen_presentation1.61807099
30MP0009764_decreased_sensitivity_to1.57958180
31MP0005083_abnormal_biliary_tract1.57152220
32MP0002166_altered_tumor_susceptibility1.57059353
33MP0004510_myositis1.56690561
34MP0004147_increased_porphyrin_level1.56062440
35MP0006292_abnormal_olfactory_placode1.52788920
36MP0003172_abnormal_lysosome_physiology1.52262912
37MP0002095_abnormal_skin_pigmentation1.52023598
38MP0005058_abnormal_lysosome_morphology1.51202574
39MP0001968_abnormal_touch/_nociception1.49172905
40MP0000858_altered_metastatic_potential1.46609929
41MP0002277_abnormal_respiratory_mucosa1.44297045
42MP0005464_abnormal_platelet_physiology1.41860226
43MP0001545_abnormal_hematopoietic_system1.41740291
44MP0005397_hematopoietic_system_phenotyp1.41740291
45MP0002723_abnormal_immune_serum1.41303468
46MP0002420_abnormal_adaptive_immunity1.41123730
47MP0002736_abnormal_nociception_after1.39954409
48MP0002398_abnormal_bone_marrow1.37769813
49MP0001944_abnormal_pancreas_morphology1.36881013
50MP0001819_abnormal_immune_cell1.36006754
51MP0001800_abnormal_humoral_immune1.35014340
52MP0005000_abnormal_immune_tolerance1.34924001
53MP0002396_abnormal_hematopoietic_system1.34424248
54MP0005409_darkened_coat_color1.34080497
55MP0005636_abnormal_mineral_homeostasis1.33048488
56MP0010155_abnormal_intestine_physiology1.29781578
57MP0002148_abnormal_hypersensitivity_rea1.28639990
58MP0004808_abnormal_hematopoietic_stem1.28574768
59MP0002693_abnormal_pancreas_physiology1.28478492
60MP0002132_abnormal_respiratory_system1.27050946
61MP0003303_peritoneal_inflammation1.26966174
62MP0009333_abnormal_splenocyte_physiolog1.26162923
63MP0005310_abnormal_salivary_gland1.25810570
64MP0001873_stomach_inflammation1.24553225
65MP0000716_abnormal_immune_system1.22946749
66MP0002722_abnormal_immune_system1.21564685
67MP0000604_amyloidosis1.21148191
68MP0002419_abnormal_innate_immunity1.21130239
69MP0005220_abnormal_exocrine_pancreas1.20845237
70MP0002429_abnormal_blood_cell1.18659870
71MP0008469_abnormal_protein_level1.18212526
72MP0002452_abnormal_antigen_presenting1.18081525
73MP0005166_decreased_susceptibility_to1.16954407
74MP0005584_abnormal_enzyme/coenzyme_acti1.15754603
75MP0000343_altered_response_to1.15344326
76MP0010234_abnormal_vibrissa_follicle1.13714222
77MP0000689_abnormal_spleen_morphology1.13635716
78MP0005501_abnormal_skin_physiology1.13533008
79MP0001663_abnormal_digestive_system1.13149892
80MP0003806_abnormal_nucleotide_metabolis1.09295323
81MP0004130_abnormal_muscle_cell1.08580619
82MP0003763_abnormal_thymus_physiology1.07956240
83MP0004883_abnormal_blood_vessel1.06975921
84MP0000703_abnormal_thymus_morphology1.06936912
85MP0002998_abnormal_bone_remodeling1.06287181
86MP0005379_endocrine/exocrine_gland_phen1.05639042
87MP0002837_dystrophic_cardiac_calcinosis1.04187620
88MP0000358_abnormal_cell_content/1.03848561
89MP0002638_abnormal_pupillary_reflex1.03591118
90MP0005084_abnormal_gallbladder_morpholo1.03025216
91MP0001845_abnormal_inflammatory_respons1.02666794
92MP0006276_abnormal_autonomic_nervous1.02460413
93MP0001790_abnormal_immune_system1.01887887
94MP0005387_immune_system_phenotype1.01887887
95MP0004947_skin_inflammation1.00642130
96MP0000490_abnormal_crypts_of0.99936929
97MP0003300_gastrointestinal_ulcer0.99466879
98MP0004859_abnormal_synaptic_plasticity0.99305502
99MP0004142_abnormal_muscle_tone0.98017636
100MP0003868_abnormal_feces_composition0.95876474
101MP0003690_abnormal_glial_cell0.95533462
102MP0003011_delayed_dark_adaptation0.94240774
103MP0003638_abnormal_response/metabolism_0.93873772
104MP0001765_abnormal_ion_homeostasis0.92710927
105MP0002733_abnormal_thermal_nociception0.92531894
106MP0001986_abnormal_taste_sensitivity0.92143530
107MP0009763_increased_sensitivity_to0.90199740
108MP0003828_pulmonary_edema0.90125806
109MP0001853_heart_inflammation0.89820763
110MP0005381_digestive/alimentary_phenotyp0.89790883
111MP0001348_abnormal_lacrimal_gland0.89768513
112MP0000749_muscle_degeneration0.89201686
113MP0001905_abnormal_dopamine_level0.89064148
114MP0003635_abnormal_synaptic_transmissio0.88084950
115MP0005390_skeleton_phenotype0.87993373
116MP0000747_muscle_weakness0.87925787
117MP0001666_abnormal_nutrient_absorption0.87170520
118MP0003693_abnormal_embryo_hatching0.86102485
119MP0001851_eye_inflammation0.86069078
120MP0001764_abnormal_homeostasis0.85302978
121MP0005332_abnormal_amino_acid0.84941824
122MP0003075_altered_response_to0.83582474
123MP0008874_decreased_physiological_sensi0.82556081
124MP0005164_abnormal_response_to0.82432666
125MP0003448_altered_tumor_morphology0.80580353
126MP0008004_abnormal_stomach_pH0.77804124
127MP0009765_abnormal_xenobiotic_induced0.68469846
128MP0000015_abnormal_ear_pigmentation0.62610396
129MP0002933_joint_inflammation0.61810136
130MP0005319_abnormal_enzyme/_coenzyme0.61118117
131MP0003795_abnormal_bone_structure0.60886838
132MP0003221_abnormal_cardiomyocyte_apopto0.60646672
133MP0004858_abnormal_nervous_system0.60586520
134MP0002332_abnormal_exercise_endurance0.60427648
135MP0002653_abnormal_ependyma_morphology0.60115201
136MP0005535_abnormal_body_temperature0.57674156
137MP0000920_abnormal_myelination0.54343399
138MP0003879_abnormal_hair_cell0.52805972
139MP0002138_abnormal_hepatobiliary_system0.52734150
140MP0001542_abnormal_bone_strength0.51838795
141MP0000249_abnormal_blood_vessel0.47459102
142MP0002019_abnormal_tumor_incidence0.46127692

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.51123549
2Eczematoid dermatitis (HP:0000976)6.27599663
3Abnormal number of erythroid precursors (HP:0012131)6.10887627
4Orchitis (HP:0100796)5.25248864
5Optic neuritis (HP:0100653)4.97806283
6Retrobulbar optic neuritis (HP:0100654)4.97806283
7Macrocytic anemia (HP:0001972)4.73490663
8Recurrent gram-negative bacterial infections (HP:0005420)4.67595141
9Reticulocytopenia (HP:0001896)4.52471985
10Stomatitis (HP:0010280)4.42789476
11Pallor (HP:0000980)4.42279093
12Gastrointestinal infarctions (HP:0005244)4.34249975
13Mediastinal lymphadenopathy (HP:0100721)4.20755592
14Hepatocellular necrosis (HP:0001404)4.07394469
15Abnormality of the heme biosynthetic pathway (HP:0010472)4.06557783
16Meningitis (HP:0001287)3.99151256
17Recurrent fungal infections (HP:0002841)3.93180712
18Recurrent skin infections (HP:0001581)3.79164376
19Mitochondrial inheritance (HP:0001427)3.77127801
20Hepatic necrosis (HP:0002605)3.66267134
21Acute necrotizing encephalopathy (HP:0006965)3.64106689
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.63313745
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.63313745
24Abnormal delayed hypersensitivity skin test (HP:0002963)3.57518261
25Encephalitis (HP:0002383)3.57393577
26Chronic otitis media (HP:0000389)3.48738712
27Recurrent cutaneous fungal infections (HP:0011370)3.46161219
28Chronic mucocutaneous candidiasis (HP:0002728)3.46161219
29Urticaria (HP:0001025)3.45706517
30Keratoconjunctivitis sicca (HP:0001097)3.42991275
31Progressive muscle weakness (HP:0003323)3.38128894
32Vasculitis (HP:0002633)3.38094711
33Abnormal mitochondria in muscle tissue (HP:0008316)3.37104108
34Keratoconjunctivitis (HP:0001096)3.21868865
35Increased intramyocellular lipid droplets (HP:0012240)3.19473982
36Thrombocytosis (HP:0001894)3.18542328
37Acute encephalopathy (HP:0006846)3.15733856
38Gingivitis (HP:0000230)3.15408645
39Cellulitis (HP:0100658)3.14764220
40Episodic fever (HP:0001954)3.11474507
41Amyloidosis (HP:0011034)3.03031716
42Increased muscle lipid content (HP:0009058)3.00923907
43Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.98865593
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96973086
45Elevated erythrocyte sedimentation rate (HP:0003565)2.94900733
46Peritonitis (HP:0002586)2.94824247
47Hemoptysis (HP:0002105)2.93160558
48Spontaneous hematomas (HP:0007420)2.87980404
49Increased CSF lactate (HP:0002490)2.86893536
50Increased hepatocellular lipid droplets (HP:0006565)2.83280778
51Pulmonary infiltrates (HP:0002113)2.82436992
52Chest pain (HP:0100749)2.79818324
53Abnormality of aromatic amino acid family metabolism (HP:0004338)2.78925869
54Increased IgM level (HP:0003496)2.76703723
55Renal Fanconi syndrome (HP:0001994)2.73548108
56Anorexia (HP:0002039)2.73244690
57Progressive macrocephaly (HP:0004481)2.72000084
58Hypochromic anemia (HP:0001931)2.69289558
59Lipid accumulation in hepatocytes (HP:0006561)2.68726144
60Inflammation of the large intestine (HP:0002037)2.66250818
61Gastrointestinal inflammation (HP:0004386)2.65787284
62Gingival bleeding (HP:0000225)2.63079735
63Lactic acidosis (HP:0003128)2.61567145
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60836484
65Abnormal protein N-linked glycosylation (HP:0012347)2.60836484
66Abnormal protein glycosylation (HP:0012346)2.60836484
67Abnormal glycosylation (HP:0012345)2.60836484
68Abnormality of glycolipid metabolism (HP:0010969)2.59602082
69Abnormality of liposaccharide metabolism (HP:0010968)2.59602082
70Abnormality of glycosphingolipid metabolism (HP:0004343)2.59602082
71Purpura (HP:0000979)2.59543255
72Progressive neurologic deterioration (HP:0002344)2.57254034
73Vacuolated lymphocytes (HP:0001922)2.56921200
74Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56175457
75Leukocytosis (HP:0001974)2.56053639
76Hypochromic microcytic anemia (HP:0004840)2.55632746
77Type I transferrin isoform profile (HP:0003642)2.54779338
78Aplastic anemia (HP:0001915)2.50656736
79Recurrent viral infections (HP:0004429)2.48082612
803-Methylglutaconic aciduria (HP:0003535)2.47861211
81Ragged-red muscle fibers (HP:0003200)2.46892620
82Hypergammaglobulinemia (HP:0010702)2.44074396
83Emotional lability (HP:0000712)2.43769418
84Arterial thrombosis (HP:0004420)2.43719638
85Pulmonary embolism (HP:0002204)2.43342064
86Loss of speech (HP:0002371)2.43253236
87Pustule (HP:0200039)2.40810849
88Abnormality of the peritoneum (HP:0002585)2.38734471
89Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38588150
90Increased serum lactate (HP:0002151)2.37784356
91Reduced antithrombin III activity (HP:0001976)2.37533116
92Agammaglobulinemia (HP:0004432)2.37530723
93Osteomyelitis (HP:0002754)2.37025778
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35411142
95Gangrene (HP:0100758)2.33801092
96Abnormality of iron homeostasis (HP:0011031)2.33679187
97Increased cerebral lipofuscin (HP:0011813)2.32902337
98Sepsis (HP:0100806)2.32822216
99Colitis (HP:0002583)2.32074797
100Hepatosplenomegaly (HP:0001433)2.29333332
101Exertional dyspnea (HP:0002875)2.28581893
102Abnormality of the pleura (HP:0002103)2.27797234
103Microretrognathia (HP:0000308)2.24389256
104Petechiae (HP:0000967)2.23953634
105Granulocytopenia (HP:0001913)2.23915764
106Systemic lupus erythematosus (HP:0002725)2.20445307
107Lymphopenia (HP:0001888)2.19920890
108Ketosis (HP:0001946)2.18509195
109Abnormality of T cells (HP:0002843)2.15514131
110Exercise intolerance (HP:0003546)2.14879251
111Prolonged bleeding time (HP:0003010)2.13758885
112Cerebral edema (HP:0002181)2.13416217
113T lymphocytopenia (HP:0005403)2.12429457
114Acne (HP:0001061)2.11139748
115Keratitis (HP:0000491)2.09743012
116Abnormality of the endocardium (HP:0004306)2.08831611
117Dysostosis multiplex (HP:0000943)2.08577311
118Erythema (HP:0010783)2.07866423
119IgM deficiency (HP:0002850)2.07179321
120Ketoacidosis (HP:0001993)2.06996380
121Achilles tendon contracture (HP:0001771)2.04833378
122Abnormality of T cell number (HP:0011839)2.04389887
123Hypertensive crisis (HP:0100735)2.04373275
124Spastic paraparesis (HP:0002313)2.04231689
125Acute hepatic failure (HP:0006554)2.02868382
126Recurrent abscess formation (HP:0002722)2.01530704
127Premature loss of primary teeth (HP:0006323)2.01356875
128Abnormality of T cell physiology (HP:0011840)2.01306360
129Abnormality of cells of the lymphoid lineage (HP:0012140)2.01034446
130Respiratory failure (HP:0002878)2.00896691
131Abnormality of dicarboxylic acid metabolism (HP:0010995)2.00824367
132Dicarboxylic aciduria (HP:0003215)2.00824367
133Methylmalonic aciduria (HP:0012120)2.00824330
134Increased serum ferritin (HP:0003281)2.00385691
135Skin rash (HP:0000988)1.99767069
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98943617
137Abnormality of alanine metabolism (HP:0010916)1.98943617
138Hyperalaninemia (HP:0003348)1.98943617
139Hyperphosphaturia (HP:0003109)1.98371133
140Recurrent bacterial skin infections (HP:0005406)1.97909302
141Delayed CNS myelination (HP:0002188)1.97034807
142Microvesicular hepatic steatosis (HP:0001414)1.96826044
143Vertigo (HP:0002321)1.96805426
144Abnormality of secondary sexual hair (HP:0009888)1.96704317
145Abnormality of the axillary hair (HP:0100134)1.96704317
146Slow saccadic eye movements (HP:0000514)1.96655004
147Glomerulopathy (HP:0100820)1.96272285
148Skin ulcer (HP:0200042)1.96226343
149Late onset (HP:0003584)1.94735487
150Cortical visual impairment (HP:0100704)1.93569614
151Epistaxis (HP:0000421)1.93381324
152Microcytic anemia (HP:0001935)1.92488220
153Abnormality of reticulocytes (HP:0004312)1.92242751
154Panhypogammaglobulinemia (HP:0003139)1.91831970
155Abnormality of the Achilles tendon (HP:0005109)1.91516228
156Polyneuropathy (HP:0001271)1.90979790
157Malnutrition (HP:0004395)1.90909015
158Progressive inability to walk (HP:0002505)1.90683942
159Increased IgE level (HP:0003212)1.90651784
160Increased neuronal autofluorescent lipopigment (HP:0002074)1.90080496
161Abnormality of transition element cation homeostasis (HP:0011030)1.89509375
162Abnormality of the nasal mucosa (HP:0000433)1.89388940
163Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.89161371
164Abnormality of polysaccharide metabolism (HP:0011012)1.88815340
165Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88815340
166Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88815340
167Migraine (HP:0002076)1.88662032
168Optic disc pallor (HP:0000543)1.88314851
169Impaired platelet aggregation (HP:0003540)1.85866043
170Abnormal platelet function (HP:0011869)1.85866043
171Abnormal hemoglobin (HP:0011902)1.85764892
172Delusions (HP:0000746)1.84786556
173Concave nail (HP:0001598)1.84006039
174Asplenia (HP:0001746)1.83867279
175Abnormality of macrophages (HP:0004311)1.83787842
176Generalized aminoaciduria (HP:0002909)1.81973078
177Abnormality of dental color (HP:0011073)1.81705283
178Visual hallucinations (HP:0002367)1.81692571
179Seborrheic dermatitis (HP:0001051)1.81435091
180Obstructive lung disease (HP:0006536)1.80030165
181Chronic obstructive pulmonary disease (HP:0006510)1.80030165
182Myositis (HP:0100614)1.77556065
183Broad face (HP:0000283)1.74907577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.63904364
2STK163.56392397
3CDK192.91359353
4ERN12.88204823
5TLK12.68586697
6TNK22.62145116
7BCKDK2.47563253
8BLK2.33325503
9CSK2.27325980
10FLT32.25543344
11TNIK2.14886786
12PIM22.10387479
13RIPK42.02451786
14MAPK151.95717825
15FES1.94056576
16DYRK31.93162537
17NME11.88351046
18ARAF1.84687016
19MAP3K121.83204942
20MUSK1.82493022
21PRPF4B1.81711734
22BUB11.78960664
23MAP2K71.74662838
24CAMKK21.74321258
25TXK1.73899582
26MAP3K31.71716591
27KIT1.67042091
28WEE11.61812481
29SCYL21.60723925
30MAP3K111.50541375
31BTK1.49724256
32MAP3K141.48379293
33TAOK31.47680724
34MAPKAPK51.44298811
35TEC1.41493263
36LRRK21.36809098
37SIK31.36095322
38GRK61.33889999
39PRKD21.32724870
40MAP4K11.29154394
41TGFBR21.20248838
42SYK1.18803206
43MAPKAPK31.18255698
44RAF11.17661449
45IRAK41.11660369
46PKN21.11275669
47IKBKB1.09468482
48MAP3K11.06985844
49ACVR1B1.05940928
50MAP3K61.04176274
51TAOK21.03593565
52DAPK31.00119225
53CAMK10.99918041
54TESK20.98611331
55HIPK20.97849676
56MAP3K70.95904654
57MAP2K60.90269967
58ITK0.90219735
59MAP3K130.90173643
60MARK30.89964066
61DYRK1B0.89835038
62JAK10.89726669
63ZAP700.88943478
64PDPK10.88350755
65TBK10.88152320
66PDK10.87083558
67PIK3CG0.85910913
68TRIB30.83492913
69IRAK30.82344861
70KDR0.81895624
71TYK20.81319749
72MAP2K20.80922490
73VRK10.80478980
74NTRK30.78196325
75BMPR20.77549205
76SIK10.76782166
77DAPK20.74576056
78IRAK20.73823655
79EPHB10.70554969
80LYN0.69197827
81MATK0.68540450
82MAP2K40.68324105
83CCNB10.67758492
84MAP3K100.66629518
85YES10.64149593
86CSF1R0.64037477
87PTK60.63891792
88FYN0.62093778
89FGFR40.61917944
90MAPK110.61314152
91MAP3K40.61016443
92KSR20.60631175
93MST40.60033999
94RPS6KB20.59669338
95ADRBK20.59275345
96MAPK40.58698075
97CDC42BPA0.58110031
98NLK0.57197596
99TESK10.56746605
100JAK30.55716241
101TGFBR10.53847168
102MAP2K30.52729245
103EPHA40.52115268
104MAP3K90.51622815
105UHMK10.51382603
106EEF2K0.50931245
107DAPK10.50797011
108MOS0.49983277
109HCK0.48781078
110AURKA0.48328610
111BMX0.48294917
112SIK20.48246595
113STK100.48141916
114PRKCQ0.48026594
115MARK20.47746288
116NEK90.47354815
117ILK0.47241685
118INSRR0.47150441
119RPS6KL10.47039443
120RPS6KC10.47039443
121BRAF0.46354205
122FGR0.45715816
123CAMKK10.45314875
124MAPK70.44642771
125MAP3K50.42886410
126EIF2AK10.42822168
127LCK0.42445843
128PTK2B0.41022161
129GRK70.40425249
130PRKCZ0.40293993
131TAOK10.39335352
132IRAK10.39159035
133RPS6KA60.38047956
134PRKG20.36530426
135IKBKE0.36511794
136STK380.36253205
137PRKD10.36116625
138MAPK120.35707728
139NTRK10.33936766
140JAK20.33649955
141RET0.32447450
142MAP3K20.32348148
143TIE10.31917372
144STK110.31705523
145PRKCD0.31359059
146PIM10.31327749
147PAK40.28631652

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.15651940
2Sulfur relay system_Homo sapiens_hsa041223.70730993
3Oxidative phosphorylation_Homo sapiens_hsa001903.66500179
4Protein export_Homo sapiens_hsa030603.35739721
5Parkinsons disease_Homo sapiens_hsa050123.20137756
6Leishmaniasis_Homo sapiens_hsa051403.17755452
7Staphylococcus aureus infection_Homo sapiens_hsa051502.97939264
8Folate biosynthesis_Homo sapiens_hsa007902.93803599
9Allograft rejection_Homo sapiens_hsa053302.74288188
10Graft-versus-host disease_Homo sapiens_hsa053322.73094419
11Alzheimers disease_Homo sapiens_hsa050102.56702180
12Autoimmune thyroid disease_Homo sapiens_hsa053202.53421640
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.26889999
14Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19367290
15Type I diabetes mellitus_Homo sapiens_hsa049402.15928460
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07811869
17RNA polymerase_Homo sapiens_hsa030202.04678624
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.96983198
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89111457
20Huntingtons disease_Homo sapiens_hsa050161.89004688
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.88285110
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87624344
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84933145
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.78291973
25Pyrimidine metabolism_Homo sapiens_hsa002401.73144390
26Asthma_Homo sapiens_hsa053101.72972862
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.68568344
28Chemokine signaling pathway_Homo sapiens_hsa040621.64743096
29Malaria_Homo sapiens_hsa051441.63774264
30Proteasome_Homo sapiens_hsa030501.61192959
31Viral myocarditis_Homo sapiens_hsa054161.59645741
32Other glycan degradation_Homo sapiens_hsa005111.53283057
33Toxoplasmosis_Homo sapiens_hsa051451.53068333
34Phagosome_Homo sapiens_hsa041451.52765198
35NF-kappa B signaling pathway_Homo sapiens_hsa040641.51464355
36Rheumatoid arthritis_Homo sapiens_hsa053231.51302507
37Influenza A_Homo sapiens_hsa051641.50804319
38DNA replication_Homo sapiens_hsa030301.50337205
39Legionellosis_Homo sapiens_hsa051341.48500621
40Measles_Homo sapiens_hsa051621.48475593
41T cell receptor signaling pathway_Homo sapiens_hsa046601.39204898
42Herpes simplex infection_Homo sapiens_hsa051681.36366225
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.35864917
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31099358
45Salmonella infection_Homo sapiens_hsa051321.29126489
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28777557
47Pentose phosphate pathway_Homo sapiens_hsa000301.21431505
48African trypanosomiasis_Homo sapiens_hsa051431.19809849
49Cardiac muscle contraction_Homo sapiens_hsa042601.19529195
50TNF signaling pathway_Homo sapiens_hsa046681.19526653
51N-Glycan biosynthesis_Homo sapiens_hsa005101.15462802
52Spliceosome_Homo sapiens_hsa030401.13924561
53B cell receptor signaling pathway_Homo sapiens_hsa046621.10278462
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09756197
55Primary immunodeficiency_Homo sapiens_hsa053401.09387062
56Jak-STAT signaling pathway_Homo sapiens_hsa046301.07843970
57Hepatitis C_Homo sapiens_hsa051601.05470674
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.04879944
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98059373
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.93861083
61Hepatitis B_Homo sapiens_hsa051610.93854517
62Non-small cell lung cancer_Homo sapiens_hsa052230.89282286
63Endocytosis_Homo sapiens_hsa041440.87606011
64VEGF signaling pathway_Homo sapiens_hsa043700.84462631
65Acute myeloid leukemia_Homo sapiens_hsa052210.83881136
66Apoptosis_Homo sapiens_hsa042100.82950045
67Base excision repair_Homo sapiens_hsa034100.82919127
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80700896
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.80619565
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78803712
71Regulation of autophagy_Homo sapiens_hsa041400.76509073
72Homologous recombination_Homo sapiens_hsa034400.75732351
73Fatty acid elongation_Homo sapiens_hsa000620.74821514
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74444874
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.74293811
76Lysosome_Homo sapiens_hsa041420.74219573
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73231595
78Sphingolipid metabolism_Homo sapiens_hsa006000.72551362
79Epstein-Barr virus infection_Homo sapiens_hsa051690.71655538
80Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71507153
81Metabolic pathways_Homo sapiens_hsa011000.71355601
82Vibrio cholerae infection_Homo sapiens_hsa051100.69557508
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69235869
84Caffeine metabolism_Homo sapiens_hsa002320.69135370
85Galactose metabolism_Homo sapiens_hsa000520.68659539
86Prolactin signaling pathway_Homo sapiens_hsa049170.67270354
87Pancreatic secretion_Homo sapiens_hsa049720.64764960
88Pancreatic cancer_Homo sapiens_hsa052120.64398808
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64121481
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63428267
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63007871
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60552299
93Chronic myeloid leukemia_Homo sapiens_hsa052200.59235253
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57832216
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56840634
96Long-term potentiation_Homo sapiens_hsa047200.55612942
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55093912
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.54422969
99Fatty acid degradation_Homo sapiens_hsa000710.53491009
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52989195
101Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52249260
102Purine metabolism_Homo sapiens_hsa002300.51947346
103Notch signaling pathway_Homo sapiens_hsa043300.51438150
104Mismatch repair_Homo sapiens_hsa034300.50953879
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50640377
106Histidine metabolism_Homo sapiens_hsa003400.50000947
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48939588
108Bladder cancer_Homo sapiens_hsa052190.47602569
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47301076
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47182099
111Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45274197
112Type II diabetes mellitus_Homo sapiens_hsa049300.44769340
113Antigen processing and presentation_Homo sapiens_hsa046120.44591464
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43568946
115Renal cell carcinoma_Homo sapiens_hsa052110.42753885
116Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42284466
117Collecting duct acid secretion_Homo sapiens_hsa049660.41710852
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41189989
119Insulin secretion_Homo sapiens_hsa049110.40549842
120Synaptic vesicle cycle_Homo sapiens_hsa047210.40233430
121HIF-1 signaling pathway_Homo sapiens_hsa040660.39913702
122Shigellosis_Homo sapiens_hsa051310.39375879
123Amphetamine addiction_Homo sapiens_hsa050310.39306896
124Osteoclast differentiation_Homo sapiens_hsa043800.39036559
125mTOR signaling pathway_Homo sapiens_hsa041500.38760371
126Pertussis_Homo sapiens_hsa051330.37998941
127Fat digestion and absorption_Homo sapiens_hsa049750.37693587
128Choline metabolism in cancer_Homo sapiens_hsa052310.37332367
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36954381
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36499905
131Biosynthesis of amino acids_Homo sapiens_hsa012300.36499537
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.36483008
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36058167
134Cysteine and methionine metabolism_Homo sapiens_hsa002700.35793538
135HTLV-I infection_Homo sapiens_hsa051660.35691101
136FoxO signaling pathway_Homo sapiens_hsa040680.35505920
137Carbon metabolism_Homo sapiens_hsa012000.35323789
138Cocaine addiction_Homo sapiens_hsa050300.35062550
139Amoebiasis_Homo sapiens_hsa051460.34571727
140Peroxisome_Homo sapiens_hsa041460.33746302
141GnRH signaling pathway_Homo sapiens_hsa049120.33734489
142Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33359279
143Tuberculosis_Homo sapiens_hsa051520.32602838
144MAPK signaling pathway_Homo sapiens_hsa040100.30559013
145Dopaminergic synapse_Homo sapiens_hsa047280.29905377
146Nucleotide excision repair_Homo sapiens_hsa034200.29451555
147Glycerophospholipid metabolism_Homo sapiens_hsa005640.29350683
148Insulin signaling pathway_Homo sapiens_hsa049100.28154897
149Platelet activation_Homo sapiens_hsa046110.27191241
150Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27031562
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26937300
152Viral carcinogenesis_Homo sapiens_hsa052030.25282892
153Calcium signaling pathway_Homo sapiens_hsa040200.25242727
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24840586
155Alcoholism_Homo sapiens_hsa050340.24755001
156Endometrial cancer_Homo sapiens_hsa052130.24738300
157Neurotrophin signaling pathway_Homo sapiens_hsa047220.23836093
158Serotonergic synapse_Homo sapiens_hsa047260.22331309
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21368043
160Insulin resistance_Homo sapiens_hsa049310.20834143
161Glycosaminoglycan degradation_Homo sapiens_hsa005310.20437238
162Glycerolipid metabolism_Homo sapiens_hsa005610.18666761
163Fructose and mannose metabolism_Homo sapiens_hsa000510.18143154
164Thyroid cancer_Homo sapiens_hsa052160.18087077
165Hematopoietic cell lineage_Homo sapiens_hsa046400.18016037

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